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Interstitial Diseases

Simon L F Walsh
No abstract text is available yet for this article.
October 18, 2018: American Journal of Respiratory and Critical Care Medicine
Ashutosh Kumar, Sanjib K Ghosh, Muneeb A Faiq, Vishwajit R Deshmukh, Chiman Kumari, Vikas Pareek
In the last few years, a cluster of anatomical discoveries has been reported which overturned the long existing dogmas about the structure and function of human body. First to come was the discovery that established the existence of a lymphatic system pertaining to the central nervous system (CNS). CNS was believed to be anatomically immune privileged owing to the absence of any lymphatics and presence of the blood-brain barrier around it, but latest research has established beyond any reasonable doubt that true lymphatic channels carry immune cells in meninges thus challenging the existing theory...
October 18, 2018: QJM: Monthly Journal of the Association of Physicians
S A Demura, E A Kogan, V L Goryachkina
The review of the literature deals with the participation of Clara cells now called club cells (CCs) of the epithelium in the respiratory and terminal bronchioles in the pathogenesis and morphogenesis of chronic inflammatory diseases, precancer, and cancer of the lung, which develop in the respiratory segments. The review summarizes data on the histophysiology of CCs and their participation in the pathogenesis and morphogenesis of chronic interstitial lung diseases, pneumoconiosis, chronic obstructive diseases, adenomatosis, and adenocarcinoma of the lung...
2018: Arkhiv Patologii
Ralf Schiel, Rolf Bambauer, Antje Steveling
Worldwide the number of people with diabetes mellitus is increasing. There are estimations that diabetes is one of the leading causes of death. The most important goals for the treatment of diabetes are self-management of the disease and an optimal quality of diabetes control. In the therapy new technologies, like real-time continuous interstitial glucose monitoring, continuous subcutaneous insulin infusion (CSII), electronic tools for the monitoring of therapeutic approaches, automated bolus calculators for insulin and electronic tools for education and information of patients, have become widespread and play important roles...
October 18, 2018: Artificial Organs
Haruki Matsumoto, Shuzo Sato, Yuya Fujita, Makiko Yashiro-Furuya, Naoki Matsuoka, Tomoyuki Asano, Hiroko Kobayashi, Hiroshi Watanabe, Kiyoshi Migita
Anti-melanoma differentiation-associated gene 5 (MDA5) antibodies are frequently detected in amyopathic dermatomyositis with rapidly progressive interstitial lung disease (RP-ILD). However, the presence of anti-MDA5 antibodies in other connective tissue diseases is not well known. We herein report a case of rheumatoid arthritis complicated with refractory anti-MDA5 antibody-positive ILD. A 75-year-old Japanese woman was referred to our hospital for refractory ILD. Serological testing was positive for anti-MDA5 antibody without any muscle or skin lesions...
October 17, 2018: Internal Medicine
Kentaro Sakashita, Kengo Murata, Yukiko Takahashi, Miake Yamamoto, Kana Oohashi, Yu Sato, Miyako Kitazono, Akihiko Wada, Mikio Takamori
Objective The standard anti-tuberculosis (TB) regimen occasionally causes acute kidney injury (AKI). The major etiology is rifampicin-induced acute interstitial nephritis. However, the standard management of AKI induced by anti-TB drugs has yet to be established. Patients and Methods We retrospectively reviewed patients with TB who developed AKI after starting standard anti-TB treatment between 2006 and 2016 at a single TB center. The clinical characteristics and the management are described. Results Among 1,430 patients with active TB, 15 (1...
October 17, 2018: Internal Medicine
Ida Aringer, Katharina Artinger, Alexander H Kirsch, Corinna Schabhüttl, Katharina Jandl, Thomas Bärnthaler, Agnes Mooslechner, Sereina A Herzog, Moritz Uhlig, Andrijana Kirsch, Sasa Frank, Miriam Banas, Marion Pollheimer, Philipp Eller, Alexander R Rosenkranz, Akos Heinemann, Kathrin Eller
Prostaglandin E2 (PGE2 ) signaling is known to modulate inflammation and vascular resistance. Receptors of PGE2 (E-type prostanoid receptors, EP) might be an attractive pharmacological target in immune-mediated diseases such as glomerulonephritis. We hypothesized that selective EP4 antagonism improves nephrotoxic serum nephritis (NTS) by its anti-inflammatory properties. Mice were subjected to NTS and treated with the EP4 antagonist ONO AE3-208 [10 mg/kg bw/day] or vehicle starting from disease initiation. In one set of experiments treatment was started 4 days after NTS induction...
October 17, 2018: American Journal of Physiology. Renal Physiology
Archana Raman, Stephen C Parnell, Yan Zhang, Gail A Reif, Yuqiao Dai, Aditi Khanna, Emily Daniel, Corey White, Jay L Vivian, Darren Paul Wallace
In polycystic kidney disease (PKD), persistent activation of cell proliferation and matrix production contributes to cyst growth and fibrosis, leading to progressive deterioration of renal function. Previously, we showed that periostin, a matricellular protein involved in tissue repair, is overexpressed by cystic epithelial cells of PKD kidneys. Periostin binds αV β3 -integrins and activates integrin-linked kinase (ILK), leading to Akt/mTOR-mediated proliferation of human PKD cells. By contrast, periostin does not stimulate the proliferation of normal human kidney cells...
October 17, 2018: American Journal of Physiology. Renal Physiology
Takahiro Shinzato, Taro Kubo, Toshihiro Shimizu, Koji Nanmoku, Takashi Yagisawa
We report a 55-year-old man with a renal allograft that developed sarcoidosis. His autosomal dominant polycystic kidney disease (ADPKD) progressed to end-stage stage renal disease when he was 52 years old, and he underwent living-donor kidney transplantation at the age of 53 years. His proteinuria worsened at 19 months post-transplantation, and his renal function began to decline at 29 months post-transplantation. A renal allograft biopsy performed at 31 months post-transplantation revealed non-caseating granulomatous interstitial nephritis...
October 16, 2018: CEN Case Reports
Yoshiaki Kinoshita, Kentaro Watanabe, Hiroshi Ishii, Hisako Kushima, Makoto Hamasaki, Masaki Fujita, Kazuki Nabeshima
Patients with autoimmune disease-related interstitial lung disease (AID-ILD) occasionally develop radiologic pleuroparenchymal fibroelastosis (PPFE)-like lesions. However, the significance of AID as an etiology of PPFE has not been fully elucidated. The aim of this study is to verify the increase of elastic fibers in AID-ILD patients and evaluate the prevalence of histological PPFE in patients with AID-ILD. We selected cases of clinically diagnosed AID-ILD and idiopathic pulmonary fibrosis (IPF), in which an autopsy had been performed or in which the patient had undergone pneumonectomy for lung transplantation...
October 16, 2018: Virchows Archiv: An International Journal of Pathology
Benjamin Kukull, Rupali S Avasare, Kelly D Smith, Donald C Houghton, Megan L Troxell, Nicole K Andeen
Collapsing glomerulopathy has been described in settings of viral infections, drug, genetic, ischemic, renal transplant, and idiopathic conditions. It has a worse prognosis than other morphologic variants of focal segmental glomerulosclerosis, and may be treated with aggressive immunosuppression. In this study, we sought to characterize the clinical and morphologic findings in older adults with collapsing glomerulopathy. Renal biopsies and associated clinical data from patients aged 65 or older with a diagnosis of collapsing glomerulopathy were retrospectively reviewed at 3 academic institutions...
October 16, 2018: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
Sarah Skeoch, Nicholas Weatherley, Andrew J Swift, Alexander Oldroyd, Christopher Johns, Conal Hayton, Alessandro Giollo, James M Wild, John C Waterton, Maya Buch, Kim Linton, Ian N Bruce, Colm Leonard, Stephen Bianchi, Nazia Chaudhuri
BACKGROUND: Drug-induced interstitial lung disease (DIILD) occurs as a result of numerous agents, but the risk often only becomes apparent after the marketing authorisation of such agents. METHODS: In this PRISMA-compliant systematic review, we aimed to evaluate and synthesise the current literature on DIILD. RESULTS: Following a quality assessment, 156 full-text papers describing more than 6000 DIILD cases were included in the review. However, the majority of the papers were of low or very low quality in relation to the review question (78%)...
October 15, 2018: Journal of Clinical Medicine
Paula Fernández-Rodríguez, Juan José Martín-Marcuartu, Jose Manuel Jiménez-Hoyuela
We present a 44-year-old woman with scapular and pelvic muscle weakness, joint inflammation, and fever. Bone scintigraphy showed high uptake in proximal regions of upper and lower limbs, suspecting inflammatory myopathy and polyarticular damage. These features were the clue to request other complementary tests such as anti-aminoacyl-tRNA-synthetase antibodies and chest CT, which showed interstitial lung disease, defining an antisynthetase syndrome. Therefore, BS allows an earlier diagnosis of inflammatory muscle disease and to identify the optimal site for muscle biopsy...
October 15, 2018: Clinical Nuclear Medicine
Thouraya Ben Salem, Cherifa Abdelkafi, Mounir Lamloum, Imed Ben Ghorbel, Mohamed Habib Houman
INTRODUCTION: Pulmonary manifestations are frequent in patients with antisynthetase syndrome which is a particular form of inflammatory myopathies. AIM: The aim of this study is to describe clinical features and long term outcome of interstitial lung disease in these patients. METHODS: This is a retrospective descriptive study in an internal medicine department. Patients with antisynthetase syndrome hospitalized from 2000 to 2014 were collected...
February 2018: La Tunisie Médicale
Sandor Koszegi, Agnes Molnar, Lilla Lenart, Judit Hodrea, Dora Bianka Balogh, Tamas Lakat, Edgar Szkibinszkij, Adam Hosszu, Nadja Sparding, Federica Genovese, Laszlo Wagner, Adam Vannay, Attila J Szabo, Andrea Fekete
KEY POINTS SUMMARY: Increased activation of the renin-angiotensin-aldosterone system (RAAS) and elevated growth factor production have crucial importance in the development of renal fibrosis leading to diabetic kidney disease. The aim of this study was to provide evidence for the antifibrotic potential of RAAS inhibitor (RAASi) treatment and to explore the exact mechanism of this protective effect. We found that RAASi ameliorate diabetes-induced renal interstitial fibrosis and decrease profibrotic growth factor production...
October 16, 2018: Journal of Physiology
Biyun Li, Xiaoxi Huang, Zheng Liu, Xuefeng Xu, Huijuan Xiao, Xin Zhang, Huaping Dai, Chen Wang
Idiopathic pulmonary fibrosis (IPF) is a lethal idiopathic interstitial pulmonary disease characterized by progressive deterioration in lung function that commonly affects eldly people. The pathogenesis of the disease is incompletely understood and therefore lacking effective therapy. Ouabain a digitalis has been reported to be able to suppress lung fibroblast activation via downregulating TGF-β-smad signal pathway in vitro . Here, we investigated the effects of ouabain in pulmonary fibrosis in vivo. Pulmonary fibrosis was induced in C57/BL6 mice by a intratracheal instillation of bleomycin (2...
2018: American Journal of Translational Research
Junghoan Park, Julip Jung, Soon Ho Yoon, Jin Mo Goo, Helen Hong, Jeong-Hwa Yoon
This study aimed to evaluate inspiratory lung expansion in patients with interstitial lung disease (ILD) using histogram analyses based on advanced image registration between inspiratory and expiratory CT scans. We included 16 female ILD patients and eight age- and sex-matched normal controls who underwent full-inspiratory and expiratory CT scans. The CT scans were sequentially aligned based on the surface, landmarks, and attenuation of the lung parenchyma. Histogram analyses were performed on the degree of lung expansion (DLE) of each pixel between the aligned images in x-, y-, z-axes, and 3-dimensionally (3D)...
October 15, 2018: Scientific Reports
Ameen Jubber, Mudita Tripathi, James Taylor
We report the case of an 80-year-old Caucasian man with PL-12 antibody positive antisynthetase syndrome. He presented with progressive dyspnoea and weight loss, later developing dysphagia, mild proximal muscle weakness and mild sicca symptoms. Investigations revealed interstitial lung disease, inflammatory myopathy and an immunology profile consistent with PL-12 antisynthetase syndrome. Prednisolone and cyclophosphamide resulted in a significant improvement of all his symptoms.
October 14, 2018: BMJ Case Reports
İpek Özmen, Elif Yıldırım, Murat Öztürk, Birsen Ocaklı, Reyhan Yıldız, Rüya Aydın, Meral Karakış, Özgür Yılmaz, Emine Aksoy
OBJECTIVES: Chronic respiratory diseases exert a global health burden with high health care costs, morbidity, and mortality. The aim of the present study was to investigate the effect of pulmonary rehabilitation (PR) on emergency admission and hospitalization rates of patients with chronic respiratory disease. MATERIALS AND METHODS: In this retrospective cohort study, hospitalization rates and emergency admissions of patients before (December 2014-December 2015) and after PR (January 2015-December 2016) were investigated...
September 13, 2018: Turkish Thoracic Journal
Laura Sommerauer, Alois Philipp, Matthias Lubnow, Thomas Müller, Dirk Lunz, Hans-Stefan Hofmann, Michael Ried
INTRODUCTION: Patients with severe respiratory failure and veno-venous extracorporeal membrane oxygenation (vv-ECMO) often require diagnostic or therapeutic thoracic surgery. METHODS: Retrospective analysis of prospectively collected data (Regensburg ECMO Registry) on all patients requiring vv-ECMO between December 2010 and December 2016 due to acute lung failure (ALF) with diagnostic or therapeutic thoracic surgery. Endpoints were the indications for thoracic surgery as well as postoperative morbidity and in-hospital mortality...
October 15, 2018: Zentralblatt Für Chirurgie
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