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https://www.readbyqxmd.com/read/29924941/therapeutic-targeting-of-vascular-remodeling-and-right-heart-failure-in-pah-with-hif-2%C3%AE-inhibitor
#1
Zhiyu Dai, Maggie M Zhu, Yi Peng, Narsa Machireddy, Colin E Evans, Roberto Machado, Xianming Zhang, You-Yang Zhao
RATIONALE: Pulmonary arterial hypertension (PAH) is a devastating disease characterized by progressive vasoconstriction and obliterative vascular remodeling that leads to right heart failure (RHF) and death. Current therapies do not target vascular remodeling and RHF, and only result in modest improvement of morbidity and mortality. OBJECTIVE: To determine whether targeting HIF-2α with a HIF-2α-selective inhibitor could reverse PAH and RHF in different rodent PAH models...
June 20, 2018: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29924939/visualizing-heterogeneous-pulmonary-ventilation-respiratory-failure-due-to-an-anterior-mediastinal-mass
#2
Antoine Desîlets, Shaf Keshavjee, Ewan C Goligher
No abstract text is available yet for this article.
June 20, 2018: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29924937/reversing-mechanoinductive-desmoplakin-dsp-expression-by-crispr-dcas9-mediated-epigenome-editing
#3
Jing Qu, Lanyan Zhu, Zijing Zhou, Ping Chen, Shuyan Liu, Morgan L Locy, Victor J Thannickal, Yong Zhou
RATIONALE: Desmoplakin (DSP), the most abundant component of desmosomes which maintain the mechanical integrity of epithelium, is a GWAS-identified genetic risk locus in human idiopathic pulmonary fibrosis (IPF). IPF subjects express a significantly higher level of DSP than control subjects. OBJECTIVES: Determine potential mechanisms by which DSP is regulated in lung fibrosis Methods: Matrigel-coated soft and stiff polyacrylamide gels were made to simulate the stiffness of normal and fibrotic lungs...
June 20, 2018: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29924876/carotid-chemoreceptors-the-link-between-pulmonary-and-cardiovascular-disease
#4
Joshua M Bock
No abstract text is available yet for this article.
June 20, 2018: Journal of Physiology
https://www.readbyqxmd.com/read/29924737/outcomes-in-oligohydramnios-the-role-of-etiology-in-predicting-pulmonary-morbidity-mortality
#5
Ashley Hesson, Elizabeth Langen
OBJECTIVE: Early-onset oligohydramnios is typically secondary to renal-urinary anomalies (RUA) or preterm premature rupture of membranes (PPROM). We compared neonatal pulmonary outcomes between these etiologies. METHODS: We conducted a retrospective cohort study of women with oligohydramnios identified before 24 completed weeks of gestation attributed to either PPROM or RUA. Patients were excluded if other fetal anomalies were noted. Respiratory morbidity was assessed by the need for oxygen at 36 corrected weeks or at hospital discharge...
June 20, 2018: Journal of Perinatal Medicine
https://www.readbyqxmd.com/read/29924458/current-controversies-in-the-stepping-up-and-stepping-down-of-inhaled-therapies-for-copd-at-the-patient-level
#6
REVIEW
Jose Luis Lopez-Campos, Laura Carrasco Hernández, Xavier Muñoz, Víctor Bustamante, Esther Barreiro
The implementation of potential new step-up or step-down treatment recommendations in response to current guidelines is one of the main challenges currently faced in actual daily practice settings. In the present narrative review, we aim to discuss the relevance of these step-up and step-down proposals at the patient level in daily clinical practice. In particular, we aim to review the challenges associated with inhaled maintenance therapy for chronic obstructive pulmonary disease (COPD) in four clinical scenarios...
June 20, 2018: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/29924447/evaluation-of-tlr2-tlr4-and-tollip-polymorphisms-for-their-role-in-tuberculosis-susceptibility
#7
Shouquan Wu, Weiwei Huang, Dan Wang, Yu Wang, Minggui Wang, Miaomiao Zhang, Jian-Qing He
Previous studies indicated that single-nucleotide polymorphisms (SNPs) of genes coding for toll-like receptors (TLRs) and toll-interacting protein (TOLLIP) may be involved in the pathogenesis of pulmonary tuberculosis (PTB). This study was designed to investigate potential associations between the polymorphisms in TLR2, TLR4, and TOLLIP and susceptibility to latent tuberculosis infection (LTBI) or subsequent PTB in a Chinese Han population. A total of 209 PTB and 201 LTBI patients and 204 healthy control subjects (HCS) were enrolled in our study...
June 2018: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
https://www.readbyqxmd.com/read/29924443/influence-of-lung-function-and-sleep-disordered-breathing-on-stroke-a-community-based-study
#8
Jingjing Zhang, Zhuoqing Gong, Ruohan Li, Ya Gao, Ying Li, Jiamei Li, Bin Yan, Gang Wang
BACKGROUND: Impaired lung function is regarded as a risk factor for stroke in patients with chronic obstructive pulmonary disease. However, the association between reduced lung function and incident stroke in a community-based population with sleep-disordered breathing (SDB) remains unknown. METHODS: We performed a prospective study within the Sleep Heart Health Study cohort. Full montage home sleep testing and spirometry data on 2082 and 2072 individuals with and without SDB, respectively, were analysed...
June 20, 2018: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/29924391/proposal-for-standardized-prenatal-ultrasound-assessment-of-the-fetus-with-congenital-diaphragmatic-hernia-by-the-european-reference-network-on-rare-inherited-and-congenital-anomalies-ernica
#9
REVIEW
Francesca Maria Russo, Anne-Gael Cordier, Luc De Catte, Julien Saada, Alexandra Benachi, Jan Deprest
Congenital diaphragmatic hernia is a rare disease associated with high mortality and morbidity. Antenatal ultrasound screening identifies more than 70% of cases, providing the opportunity for in-utero referral to a tertiary care center for expert assessment and perinatal management. Additional genetic and morphologic assessment may be used to rule out associated anomalies. In isolated cases, the outcome may be predicted prenatally by medical imaging. The combination of lung size and liver herniation is a widely accepted method to stratify fetuses into groups with an increasing degree of pulmonary hypoplasia and corresponding mortality rates...
June 20, 2018: Prenatal Diagnosis
https://www.readbyqxmd.com/read/29924383/the-neutrophil-to-lymphocyte-ratio-as-a-marker-of-chronic-obstructive-pulmonary-disease-and-its-exacerbations-a-systematic-review-and-meta-analysis
#10
REVIEW
Panagiotis Paliogiannis, Alessandro G Fois, Salvatore Sotgia, Arduino A Mangoni, Elisabetta Zinellu, Pietro Pirina, Ciriaco Carru, Angelo Zinellu
INTRODUCTION: The main white blood cell populations, neutrophils and lymphocytes, are involved in the pathophysiology of chronic obstructive pulmonary disease (COPD). We conducted a systematic review and meta-analysis of studies investigating the relationship between the neutrophil to lymphocyte ratio (NLR, a marker of subclinical inflammation), presence of COPD, and its exacerbations. METHODS: A comprehensive literature search was conducted in Pubmed, Web of Science and Scopus databases; two investigators independently reviewed suitable studies...
June 20, 2018: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29924380/time-to-effect-guided-pulmonary-vein-isolation-utilizing-the-third-generation-versus-second-generation-cryoballoon-one-year-clinical-success
#11
Christian-Hendrik Heeger, Christopher Schuette, Valentina Seitelberger, Erik Wissner, Andreas Rillig, Shibu Mathew, Bruno Reissmann, Christine Lemes, Tilman Maurer, Thomas Fink, Osamu Inaba, Naotaka Hashiguchi, Francesco Santoro, Feifan Ouyang, Karl-Heinz Kuck, Andreas Metzner
BACKGROUND: The second-generation cryoballoon (CB2) provides effective and durable pulmonary vein isolation (PVI) associated with encouraging and reproducible clinical outcome data. The latest-generation cryoballoon (CB3) incorporates a 40% shorter distal tip, thus allowing for an increased rate of PVI real-time signal recording and facilitating individualized ablation strategies taking the time-to-effect (TTE) into account. However, whether this characteristic translates into favorable clinical success has not been evaluated yet...
June 20, 2018: Cardiology Journal
https://www.readbyqxmd.com/read/29924305/telocytes-promote-vegf-expression-and-alleviate-ventilator-induced-lung-injury-in-mice
#12
Ruihua Ma, Pinwen Wu, Qiqing Shi, Dongli Song, Hao Fang
Mechanical ventilation (MV) is an important procedure for the treatment of patients with acute lung injury or acute respiratory distress syndrome in a clinical setting; however, MV can lead to severe complications, including ventilator-induced lung injury (VILI). Telocytes (TCs) can promote tissue repair following injury in the heart, kidneys, and other organs. The aim of this study was to investigate the role of TCs in VILI in mice and the associated mechanisms. By using in vivo studies in mice and in vitro studies in cells, we demonstrated that an airway injection of TCs can reduce the pulmonary inflammatory response and improve the lung function in mice with VILI and promote the proliferation of pulmonary vascular endothelial cells...
June 19, 2018: Acta Biochimica et Biophysica Sinica
https://www.readbyqxmd.com/read/29924283/-tuberculosis-that-mimics-cancer-cases-referred-to-the-national-institute-of-neoplastic-diseases-lima-peru
#13
Juliana R Villena-Suarez, William Vicente, Luis Taxa, Luis Cuéllar, Maria T Nuñez-Butrón, Valeria Villegas, Miluska Castillo, Carlos A Castañeda
Tuberculosis (TB) is a major public health problem that, due to the clinical variability of its presentation, can be confused with cancer. The aim of this study was to identify the clinical-radiological characteristics and to describe the methodology that allowed to achieve a TB diagnosis in patients referred to the National Institute of Neoplastic Diseases (INEN) with a presumed diagnosis of cancer between 2014 and 2016. The study included 170 patients (52.4% men) with an average age of 41.1 years; 18% presented a history of contact with TB, and 5...
January 2018: Revista Peruana de Medicina Experimental y Salud Pública
https://www.readbyqxmd.com/read/29924239/tuberous-sclerosis-complex-review-based-on-new-diagnostic-criteria
#14
Larissa Karine Leite Portocarrero, Klícia Novais Quental, Luciana Paula Samorano, Zilda Najjar Prado de Oliveira, Maria Cecília da Matta Rivitti-Machado
Tuberous sclerosis complex is a multisystemic, autosomal dominant genetic disorder with complete penetrance, that can evolve with hamartomas in multiple organs, such as skin, central nervous system, kidney and lung. Due to the wide phenotypic variability, the disease is often not recognized. Tuberous sclerosis complex affects one in 10,000 newborns and most patients are diagnosed during the first 15 months of life. The diagnostic criteria for tuberous sclerosis were reviewed in 2012, at the second International Tuberous Sclerosis Complex Consensus Conference...
June 2018: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/29924206/effect-of-hyperbaric-oxygenation-on-the-expression-of-glutathione-peroxidase-4-and-lactoperoxidase-genes-in-the-lung-of-isogenic-mice-after-ischemia-reperfusion-injury-in-the-small-bowel
#15
Adauto Tsutomu Ikejiri, Frederico Somaio Neto, Paulo Roberto Bertoletto, José Carlos Chaves, Alexandre Key WakateTeruya, Cândida Aparecida Leite Kassuya, Murched Omar Taha, Djalma José Fagundes
PURPOSE: To evaluate the effect of hyperbaric oxygenation (HBO) on the expression of the genes antioxidant glutathione peroxidase 4 (Gpx4) and lactoperoxidase (Lpo) in the lung of mice subjected to intestinal ischemia and reperfusion (IIR). METHODS: Control group (CG) in which were subjected to anesthesia, laparotomy and observation for 120 minutes; an ischemia and reperfusion group (IRG) subjected to anesthesia, laparotomy, small bowel ischemia for 60 minutes and reperfusion for 60 minutes; and three groups treated with HBO during ischemia (HBOG + I), during reperfusion (HBOG + R) and during ischemia and reperfusion (HBOG + IR)...
May 2018: Acta Cirúrgica Brasileira
https://www.readbyqxmd.com/read/29924184/the-influence-of-inspiratory-muscle-training-combined-with-the-pilates-method-on-lung-function-in-elderly-women-a-randomized-controlled-trial
#16
Guilherme Medeiros de Alvarenga, Simone Arando Charkovski, Larissa Kelin Dos Santos, Mayara Alves Barbosa da Silva, Guilherme Oliveira Tomaz, Humberto Remigio Gamba
OBJECTIVE: Aging is progressive, and its effects on the respiratory system include changes in the composition of the connective tissues of the lung that influence thoracic and lung compliance. The Powerbreathe® K5 is a device used for inspiratory muscle training with resistance adapted to the level of the inspiratory muscles to be trained. The Pilates method promotes muscle rebalancing exercises that emphasize the powerhouse. The aim of this study was to evaluate the influence of inspiratory muscle training combined with the Pilates method on lung function in elderly women...
2018: Clinics
https://www.readbyqxmd.com/read/29924183/study-on-the-correlation-between-barium-radiography-and-pulmonary-infection-rate-in-the-evaluation-of-swallowing-function
#17
Jie Sun, Zeheng Li
OBJECTIVES: To compare the results respectively obtained from the utilization of 60% barium sulfate suspension and Iohexol as contrast agents for videofluoroscopic swallowing studies and the relationship between the clinical application of the two kinds of contrast agents and the incidence of pneumonia. METHODS: Sixty cases of stroke patients with dysphagia were selected in rehabilitation department of our hospital, and the gender, age, position of the disease, and stroke nature between groups had no significant difference...
2018: Clinics
https://www.readbyqxmd.com/read/29924044/pulmonary-hemangioma-mimicking-bronchiectasis-a-case-report
#18
Wei Li, Tong Xin, Yuxin Hu, Peng Gao, Mo Chen, Jie Zhang
RATIONALE: Pulmonary hemangioma is a rare thoracic condition that can lead to hemoptysis. Here we report a case that presented with lumen dilatation suggestive of bronchiectasis on high-resolution computed tomography (CT) and was misdiagnosed as bronchiectasis for more than 10 years. PATIENT CONCERNS: A 41-year-old female patient was admitted to the Department of Respiratory Medicine due to hemoptysis. DIAGNOSES: The patient was misdiagnosed as having bronchiectasis for more than 10 years...
June 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29924042/transcutaneous-electric-nerve-stimulation-over-acupoints-for-chronic-obstructive-pulmonary-disease-protocol-for-a-systematic-review-and-meta-analysis
#19
Jia-Jia Wang, Yang Xie, Hu-Lei Zhao, Wei-Hong Han, Xiao-Chun Wang
BACKGROUND: There is a limited evidence concerning the efficacy of transcutaneous electric nerve stimulation over acupoints (Acu-TENS) for chronic obstructive pulmonary disease (COPD). Thus, this review aims to systematically determine the effect of Acu-TENS on COPD. METHODS: PubMed, Embase, The Cochrane Library, Web of Science, Chinese Biomedical Literature Database, China National Knowledge Infrastructure, Chongqing VIP, and Wanfang Data will be searched from their inception to May 10, 2018...
June 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29924023/small-cell-lung-cancer-mimicking-lymphoma-in-ct-and-68ga-dota-noc-pet-ct-a-case-report
#20
Liyan Lu, Fengfang Li, Yamei Zhang, Peng Wang, Xindao Yin, Wenbin Li
RATIONALE: Small cell lung cancer accounts for 15-20% of all lung cancers and is the most common pulmonary neuroendocrine neoplasm. Most small cell lung cancers arise from lobar or main bronchi, the most common manifestations of small cell lung cancer is a large mass centrally located within the lung parenchyma or a mediastinal mass involving the hilus. Small cell lung cancer is easily ignored by clinicians without lung parenchyma and hilus involvement. Here, we report a case of small cell lung cancer, which was misdiagnosed as the lymphoma in contrast enhanced CT and Ga-DOTA-NOC PET/CT imagings...
June 2018: Medicine (Baltimore)
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