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https://www.readbyqxmd.com/read/29471594/year-in-review-2017-interstitial-lung-disease-pulmonary-vascular-disease-and-sleep
#1
REVIEW
Amanda J Piper, Stephen J Wort, Elisabetta A Renzoni, Vasileios Kouranos
No abstract text is available yet for this article.
February 22, 2018: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/29471542/specialized-pro-resolving-lipid-mediators-regulate-ozone-induced-pulmonary-and-systemic-inflammation
#2
Brita Kilburg-Basnyat, Sky W Reece, Miranda J Crouch, Bin Luo, Andria D Boone, Michael Yaeger, Myles Hodge, Christine Psaltis, Johanna L Hannan, Jonathan Manke, Michael L Armstrong, Nichole Reisdorph, Robert M Tighe, Saame Raza Shaikh, Kymberly M Gowdy
Exposure to ozone (O3) induces lung injury, pulmonary inflammation, and alters lipid metabolism. During tissue inflammation, specialized pro-resolving lipid mediators (SPMs) facilitate the resolution of inflammation. SPMs regulate the pulmonary immune response during infection and allergic asthma; however, the role of SPMs in O3-induced pulmonary injury and inflammation is unknown. We hypothesized that O3 exposure induces pulmonary inflammation by reducing SPMs. To evaluate this, male C57Bl/6J mice were exposed to filtered air (FA) or 1 ppm O3 for 3h and necropsied 24h after exposure...
February 19, 2018: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/29471517/the-role-of-the-ground-glass-opacity-ratio-in-resected-lung-adenocarcinoma
#3
Tsai-Wang Huang, Kuan-Hsun Lin, Hsu-Kai Huang, Yi-I Chen, Kai-Hsiung Ko, Cheng-Kuang Chang, Hsian-He Hsu, Hung Chang, Shih-Chun Lee
OBJECTIVES: The goal of this study was to investigate the role of the ground-glass opacity (GGO) ratio in lung adenocarcinoma in predicting surgical outcomes. METHODS: Patients who underwent surgical resection for pulmonary adenocarcinoma between January 2004 and December 2013 were reviewed. The clinical data, imaging characteristics of nodules, surgical approaches and outcomes were analysed with a mean follow-up of 87 months. RESULTS: Of 789 enrolled patients, 267 cases were categorized as having a GGO ratio ≥0...
February 19, 2018: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/29471466/changes-in-metabolites-present-in-lung-lining-fluid-following-exposure-of-humans-to-ozone
#4
WanYun Cheng, Kelly E Duncan, Andrew J Ghio, Cavin Ward-Caviness, Edward D Karoly, David Diaz-Sanchez, Rory B Conolly, Robert B Devlin
Controlled human exposure to the oxidant air pollutant ozone causes decrements in lung function and increased inflammation as evidenced by neutrophil influx into the lung and increased levels of proinflammatory cytokines in the airways. Here we describe a targeted metabolomics evaluation of human bronchioalveolar lavage fluid (BALF) following controlled in vivo exposure to ozone to gain greater insight into its pulmonary effects. In a two-arm cross-over study, each healthy adult human volunteer was randomly exposed to filtered air (FA) and to 0...
February 19, 2018: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/29471304/pulmonary-arterial-hypertension-and-the-kidney-getting-to-the-heart-of-the-matter
#5
Amir Kazory, Edward A Ross
No abstract text is available yet for this article.
February 22, 2018: American Journal of Nephrology
https://www.readbyqxmd.com/read/29471290/presence-of-kidney-disease-as-an-outcome-predictor-in-patients-with-pulmonary-arterial-hypertension
#6
Laurent Bitker, Florence Sens, Cécile Payet, Ségolène Turquier, Antoine Duclos, Vincent Cottin, Laurent Juillard
BACKGROUND: Pulmonary arterial hypertension (PAH) may lead to right heart failure and subsequently alter glomerular filtration rates (GFR). Chronic kidney disease (CKD, GFR <60 mL/min/1.73 m2) may also adversely affect PAH prognosis. This study aimed to assess how right heart hemodynamics was associated with reduced estimated GFR (eGFR) and the association of CKD with survival in PAH patients. METHODS: In a prospective PAH cohort (2003-2012), invasive hemodynamics and eGFR were collected at diagnosis (179 patients) and during follow-up (159 patients)...
February 22, 2018: American Journal of Nephrology
https://www.readbyqxmd.com/read/29471112/evaluation-of-two-commercial-real-time-pcr-kits-a-fumigatus-%C3%A2-bio-evolution-and-mycogenie-%C3%A2-a-fumigatus-for-aspergillus-dna-detection-in-bronchoalveolar-lavage-fluid-in-patients-with-invasive-pulmonary-aspergillosis
#7
Julie Denis, Faezeh Forouzanfar, Raoul Herbrecht, Elise Toussaint, Romain Kessler, Marcela Sabou, Ermanno Candolfi, Valérie Letsher-Bru
Invasive pulmonary aspergillosis (IPA) is a common complication of immunosuppression. Rapid diagnosis using molecular techniques is essential to improve patient survival. PCR techniques are promising in enhancing Aspergillus detection in blood and respiratory samples. Here, we evaluate for the first time the performances of two commercial Real-Time PCR kits, the A. fumigatus® Bio-Evolution and the MycoGENIE® A. fumigatus for the detection of A. fumigatus DNA in broncho-alveolar lavage (BAL) from patients with and without IPA...
February 19, 2018: Journal of Molecular Diagnostics: JMD
https://www.readbyqxmd.com/read/29471085/houttuynia-cordata-polysaccharides-ameliorate-pneumonia-severity-and-intestinal-injury-in-mice-with-influenza-virus-infection
#8
Haiyan Zhu, Xiaoxiao Lu, Lijun Ling, Hong Li, Yingye Ou, Xunlong Shi, Yan Lu, Yunyi Zhang, Daofeng Chen
ETHNOPHARMACOLOGICAL RELEVANCE: Hottuynia cordata is an important traditional Chinese medicine for the treatment of respiratory diseases including bacterial and viral infections. Polysaccharides isolated from Houttuynia cordata (HCP), as its main ingredients, have been demonstrated to ameliorate the LPS-induced acute lung injury in mice. The study aimed to determine the protective effects of HCP on multiple organ injury in influenza A virus (IAV) H1N1 infected mice and its primary mechanisms in anti-inflammation and immune regulation...
February 19, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29471029/the-contribution-of-left-heart-disease-in-copd-patients-with-pulmonary-hypertension
#9
Dimitra Lepida, Athanasios Papathanasiou, Eftychia Galiatsou, George Nakos, Ioannis Goudevenos, Vasilios Koulouras
BACKGROUND: Pulmonary hypertension (PH), regardless of its aetiology, is associated with an impaired outcome in patients with chronic obstructive pulmonary disease (COPD). The aim of our study was to determine the incidence, the cause and impact of PH as detected by echocardiography in COPD patients. METHODS: Patients with confirmed COPD of any stage were evaluated by echocardiography for the likelihood of PH according to the proposed criteria. Patients with possible/likely to have PH underwent right heart catheterization, upon agreement, to confirm the presence, severity and cause of PH...
February 19, 2018: Hellenic Journal of Cardiology: HJC, Hellēnikē Kardiologikē Epitheōrēsē
https://www.readbyqxmd.com/read/29470939/free-breathing-pulmonary-mr-imaging-to-quantify-regional-ventilation
#10
Dante P I Capaldi, Rachel L Eddy, Sarah Svenningsen, Fumin Guo, John S H Baxter, A Jonathan McLeod, Parameswaran Nair, David G McCormack, Grace Parraga
Purpose To measure regional specific ventilation with free-breathing hydrogen 1 (1 H) magnetic resonance (MR) imaging without exogenous contrast material and to investigate correlations with hyperpolarized helium 3 (3 He) MR imaging and pulmonary function test measurements in healthy volunteers and patients with asthma. Materials and Methods Subjects underwent free-breathing1 H and static breath-hold hyperpolarized3 He MR imaging as well as spirometry and plethysmography; participants were consecutively recruited between January and June 2017...
February 22, 2018: Radiology
https://www.readbyqxmd.com/read/29470912/halloysite-nanotubes-induced-al-accumulation-and-fibrotic-response-in-lung-of-mice-after-30-day-repeated-oral-administration
#11
Xue Wang, Jiachun Gong, Rui Rong, Zongxiang Gui, Tingting Hu, Xiaolong Xu
Halloysite (Al2Si2O5(OH)4·nH2O) nanotubes (HNTs) are natural clay materials with hollow tubular structures and are widely applied in many fields. Many in vitro studies indicate that HNTs exhibit a high level of biocompatibility; however the in vivo toxicity of HNTs remains unclear. In this study, the bio-distribution and pulmonary toxicity of the purified HNTs in mice were investigated after intragastric administration for 30 days. HNTs have high stability in biological conditions. Oral administration of HNTs caused significant Al accumulation predominantly in the lung with relative slight effects on Si bio-distribution...
February 22, 2018: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29470835/costs-of-disease-relapses-among-individuals-with-granulomatosis-with-polyangiitis-or-microscopic-polyangiitis-in-the-united-states
#12
Amanda M Kong, Gilwan Kim, Margaret Michalska, Jennie H Best
INTRODUCTION: Granulomatosis with polyangiitis (GPA) and microscopic polyangiitis (MPA) are two related forms of systemic vasculitis. Patients with these conditions often experience relapses affecting various body systems. Here we describe rates of relapse and review healthcare costs resulting from relapse among patients with GPA/MPA. METHODS: Two groups of patients with GPA and MPA were selected from the MarketScan claims databases between 2011 and 2013 based on diagnosis codes...
February 22, 2018: Rheumatology and Therapy
https://www.readbyqxmd.com/read/29470706/reduced-proliferation-capacity-of-lung-cells-in-chronic-obstructive-pulmonary-disease
#13
Babett Bartling, Hans-Stefan Hofmann
BACKGROUND AND OBJECTIVES: The prevalence of chronic obstructive pulmonary disease (COPD) and lung emphysema increases with age and both lung diseases are again risk factors for lung cancer. Since a reduced capacity of fibroblasts for proliferation is a good indicator of tissue aging, we studied the cell proliferation of lung fibroblasts from normal and tumor tissue of lung cancer patients depending on lung comorbidities. MATERIAL AND METHODS: Fibroblasts were isolated from tumor and normal lung tissue of 40 lung cancer patients...
February 22, 2018: Zeitschrift Für Gerontologie und Geriatrie
https://www.readbyqxmd.com/read/29470660/the-effect-of-inhalant-organic-dust-on-bone-health
#14
REVIEW
Joseph M Carrington, Jill A Poole
PURPOSE OF REVIEW: Agriculture remains a major economic sector globally, and workers experience high rates of chronic inflammatory lung and musculoskeletal diseases. Whereas obstructive pulmonary diseases are known risk factors for bone loss, the underlying relationship between lung inflammation and bone health is not well known. RECENT FINDINGS: An agriculture organic dust extract inhalation animal model has recently linked lung injury-induced inflammation to systemic bone loss...
February 22, 2018: Current Allergy and Asthma Reports
https://www.readbyqxmd.com/read/29470642/real-world-switching-to-riociguat-management-and-practicalities-in-patients-with-pah-and-cteph
#15
Henning Gall, Jean-Luc Vachiéry, Nobuhiro Tanabe, Michael Halank, Mauricio Orozco-Levi, Lisa Mielniczuk, MiKyung Chang, Kai Vogtländer, Ekkehard Grünig
PURPOSE: A proportion of patients with pulmonary arterial hypertension (PAH) and chronic thromboembolic pulmonary hypertension (CTEPH) do not achieve treatment goals or experience side effects on their current therapy. In such cases, switching patients to a new drug while discontinuing the first may be a viable and appropriate treatment option. CAPTURE was designed to investigate how physicians manage the switching of patients to riociguat in real-world clinical practice. Observations from the study were used to assess whether recommendations in the riociguat prescribing information are reflected in clinical practice...
February 22, 2018: Lung
https://www.readbyqxmd.com/read/29470529/xenopus-an-alternative-model-system-for-identifying-muco-active-agents
#16
Hyo Jung Sim, Sang-Hyun Kim, Kyung-Jae Myung, Taejoon Kwon, Hyun-Shik Lee, Tae Joo Park
The airway epithelium in human plays a central role as the first line of defense against environmental contaminants. Most respiratory diseases such as chronic obstructive pulmonary disease (COPD), asthma, and respiratory infections, disturb normal muco-ciliary functions by stimulating the hypersecretion of mucus. Several muco-active agents have been used to treat hypersecretion symptoms in patients. Current muco-active reagents control mucus secretion by modulating either airway inflammation, cholinergic parasympathetic nerve activities or by reducing the viscosity by cleaving crosslinking in mucin and digesting DNAs in mucus...
2018: PloS One
https://www.readbyqxmd.com/read/29470502/chronic-obstructive-pulmonary-disease-copd-as-a-disease-of-early-aging-evidence-from-the-epichron-cohort
#17
Miguel J Divo, Bartolome R Celli, Beatriz Poblador-Plou, Amaia Calderón-Larrañaga, Juan Pablo de-Torres, Luis A Gimeno-Feliu, Juan Bertó, Javier J Zulueta, Ciro Casanova, Victor M Pinto-Plata, Carlos Cabrera-Lopez, Francesca Polverino, Jonás Carmona Píréz, Alexandra Prados-Torres, Jose M Marin
BACKGROUND: Aging is an important risk factor for most chronic diseases. Patients with COPD develop more comorbidities than non-COPD subjects. We hypothesized that the development of comorbidities characteristically affecting the elderly occur at an earlier age in subjects with the diagnosis of COPD. METHODS AND FINDINGS: We included all subjects carrying the diagnosis of COPD (n = 27,617), and a similar number of age and sex matched individuals without the diagnosis, extracted from the 727,241 records of individuals 40 years and older included in the EpiChron Cohort (Aragon, Spain)...
2018: PloS One
https://www.readbyqxmd.com/read/29470455/urban-rural-county-and-state-differences-in-chronic-obstructive-pulmonary-disease-united-states-2015
#18
Janet B Croft, Anne G Wheaton, Yong Liu, Fang Xu, Hua Lu, Kevin A Matthews, Timothy J Cunningham, Yan Wang, James B Holt
Chronic obstructive pulmonary disease (COPD) accounts for the majority of deaths from chronic lower respiratory diseases, the third leading cause of death in the United States in 2015 and the fourth leading cause in 2016.* Major risk factors include tobacco exposure, occupational and environmental exposures, respiratory infections, and genetics.† State variations in COPD outcomes (1) suggest that it might be more common in states with large rural areas. To assess urban-rural variations in COPD prevalence, hospitalizations, and mortality; obtain county-level estimates; and update state-level variations in COPD measures, CDC analyzed 2015 data from the Behavioral Risk Factor Surveillance System (BRFSS), Medicare hospital records, and death certificate data from the National Vital Statistics System (NVSS)...
February 23, 2018: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/29470355/effects-of-warm-versus-cold-ischemic-donor-lung-preservation-on-the-underlying-mechanisms-of-injuries-during-ischemia-and-reperfusion
#19
Ilker Iskender, Marcelo Cypel, Tereza Martinu, Manyin Chen, Jin Sakamoto, Hyunhee Kim, Keke Yu, Huiqing Lin, Zehong Guan, Kohei Hashimoto, Thomas K Waddell, Mingyao Liu, Shaf Keshavjee
BACKGROUND: Ischemia-reperfusion injury related to lung transplantation is a major contributor to early postoperative morbidity and mortality. We hypothesized that donation after cardiac death donor lungs experience warm ischemic conditions that activate different injurious mechanisms compared with donor lungs that undergo prolonged cold ischemic conditions. METHODS: Rat donor lungs were preserved under different cold ischemic times (CIT: 12 hours or 18 hours), or under warm ischemia time (WIT: 3 hours) after cardiac death, followed by single left lung transplantation...
February 20, 2018: Transplantation
https://www.readbyqxmd.com/read/29470256/systematic-screening-in-hereditary-hemorrhagic-telangiectasia-a-review
#20
Steven Kroon, Repke J Snijder, Marie E Faughnan, Hans-Jurgen Mager
PURPOSE OF REVIEW: Hereditary hemorrhagic telangiectasia (HHT) is an autosomal dominant inherited disease characterized by telangiectasia and arteriovenous malformations (AVMs). To date, five genetic types of HHT and one combined juvenile polyposis syndrome and HHT are known. Clinical and genetic screening of patients suspected with HHT is recommended to confirm the diagnosis and to prevent complications associated with HHT. The aim of this article is to give an overview of the evidence and to formulate a recommendation for clinicians concerning screening for HHT...
February 20, 2018: Current Opinion in Pulmonary Medicine
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