keyword
MENU ▼
Read by QxMD icon Read
search

Pulmonary

keyword
https://www.readbyqxmd.com/read/29679771/extracorporeal-photopheresis-improves-survival-in-hematopoietic-cell-transplant-patients-with-bronchiolitis-obliterans-syndrome-without-significantly-impacting-measured-pulmonary-functions
#1
Mehrdad Hefazi, Kimberly J Langer, Nandita Khera, Jill Adamski, Vivek Roy, Jeffrey L Winters, Dennis A Gastineau, Eapen K Jacob, Justin D Kreuter, Manish J Gandhi, William J Hogan, Mark R Litzow, Shahrukh K Hashmi, Hemang Yadav, Vivek N Iyer, J P Scott, Mark E Wylam, Rodrigo Cartin-Ceba, Mrinal M Patnaik
We carried out the first matched retrospective cohort study aimed at studying the safety and efficacy of extracorporeal photopheresis (ECP) for bronchiolitis obliterans syndrome (BOS) following allogeneic hematopoietic cell transplantation (HCT). Medical records of 1325 consecutive adult patients who underwent HCT between 2005 and 2015 were reviewed. Seventy-four patients (median age, 51 years) with a diagnosis of BOS were included in the study. After propensity-score matching for BOS severity, 26 patients who underwent ≥3 months of ECP were matched to 26 non-ECP-treated patients, who were assigned an index date corresponding to the ECP start date for their matched pairs...
April 18, 2018: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/29679740/dissecting-host-cell-death-programs-in-the-pathogenesis-of-influenza
#2
Jeffrey Downey, Erwan Pernet, François Coulombe, Maziar Divangahi
Influenza A virus (IAV) is a pulmonary pathogen, responsible for significant yearly morbidity and mortality. Due to the absence of highly effective antiviral therapies and vaccine, as well as the constant threat of an emerging pandemic strain, there is considerable need to better understand the host-pathogen interactions and the factors that dictate a protective versus detrimental immune response to IAV. Even though evidence of IAV-induced cell death in human pulmonary epithelial and immune cells has been observed for almost a century, very little is known about the consequences of cell death on viral pathogenesis...
April 18, 2018: Microbes and Infection
https://www.readbyqxmd.com/read/29679722/pulmonary-lymphatic-vessel-morphology-a-review
#3
REVIEW
E Weber, F Sozio, A Borghini, P Sestini, E Renzoni
Our understanding of lymphatic vessels has been advanced by the recent identification of relatively specific lymphatic endothelium markers, including Prox-1, VEGFR3, podoplanin and LYVE-1. The use of lymphatic markers has led to the observation that, contrary to previous assumptions, human lymphatic vessels extend deep inside the pulmonary lobule, either in association with bronchioles, intralobular arterioles or small pulmonary veins. Pulmonary lymphatic vessels may thus be classified into pleural, interlobular (in interlobular septa) and intralobular...
April 18, 2018: Annals of Anatomy, Anatomischer Anzeiger: Official Organ of the Anatomische Gesellschaft
https://www.readbyqxmd.com/read/29679710/cpg-oligodeoxynucleotides-may-be-effective-for-preventing-ionizing-radiation-induced-pulmonary-fibrosis
#4
Chao Zhang, Hainan Zhao, Bai-Long Li, Fu-Gao, Hu Liu, Jian-Ming Cai
Pulmonary fibrosis is a serious adverse effect of radiotherapy for thoracic tumor, which is believed to be a process that is tightly regulated by the phenotype of the developing Th response after radiation. Here, we will investigate whether CpG-oligodeoxynucleotides (ODN) prevent radiation-induced pulmonary fibrosis by shifting the imbalance of Th1 and Th2 response and summarizes the possible mechanism. In this study, female C57BL/6 mice were chosen to preform pulmonary fibrosis model, the whole-thorax of mice was exposed to a single radiation dose of 15 Gy...
April 18, 2018: Toxicology Letters
https://www.readbyqxmd.com/read/29679599/mortality-in-pulmonary-arterial-hypertension-patients-treated-with-continuous-prostanoids
#5
S D Bartolome, N Sood, T S Shah, K Styrvoky, F T Torres, K M Chin
INTRODUCTION: Parenteral prostanoids are considered the treatment of choice for patients with severe pulmonary arterial hypertension (PAH). Prognostic studies for patients treated in the modern era are limited. METHODS: In this retrospective cohort study, patients initiating IV epoprostenol or IV or SC treprostinil therapy for PAH from 2007-2016 at UT Southwestern, Dallas, TX and Ohio State University, Columbus, OH were included. Transplant-free survival was assessed from the time of IV/SC initiation and from the time of first follow-up...
April 18, 2018: Chest
https://www.readbyqxmd.com/read/29679596/observational-studies-of-inhaled-corticosteroid-effectiveness-in-copd-lessons-learned
#6
Samy Suissa, Pierre Ernst
BACKGROUND: Randomized controlled trials at times investigate findings suggested by observational studies. For example, the TORCH trial, which did not show a mortality reduction with inhaled corticosteroids (ICS) in chronic obstructive pulmonary disease (COPD), was motivated by some observational studies that suggested considerable reductions in mortality with these drugs. Reasons for these discrepancies are unclear. METHODS: We searched the literature to identify all observational studies, including cohort and case-control studies, investigating the effectiveness of ICS on major outcomes in COPD patients, including death and hospitalization for COPD...
April 18, 2018: Chest
https://www.readbyqxmd.com/read/29679545/the-impact-of-ocular-tuberculosis-on-vision-after-two-months-of-intensive-therapy
#7
Suzana Batista Vereza de Oliveira, Ângelo Ferreira Passos, David Jamil Hadad, Lorena Zbyszynski, Pedro Sousa de Almeida Júnior, Luiz Guilherme Schmidt Castellani, Reynaldo Dietze, Moisés Palaci
Tuberculosis (TB) is an infectious disease of global importance with major economic and social burden accounting for 25% of all avoidable deaths in developing countries. Extrapulmonary involvement may occur either in association with clinically apparent pulmonary tuberculosis or in isolation. This cross-sectional descriptive study aimed to evaluate the impact of ocular tuberculosis in visual acuity at baseline and after two months of intensive anti-tuberculous therapy. A sample of 133 pulmonary TB patients, seven disseminated TB, and three pleural TB patients was evaluated...
April 18, 2018: Brazilian Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29679436/fungal-infections-in-hematopoietic-stem-cell-transplantation-in-children-at-a-pediatric-children-s-hospital-in-argentina
#8
Sergio Miguel Gomez, Miguela Caniza, Alicira Fynn, Cecilia Vescina, Claudia Ruiz, Daniela Iglesias, Fernanda Sosa, Lillian Sung
Our primary objective was to describe the incidence of proven or probable invasive fungal infections (IFIs), a devastating complication of hematopoietic stem cell transplant (HSCT), in HCST in a middle-income country. Secondary objectives were to describe factors associated with IFIs and outcomes. In this single center retrospective study, pediatric patients who underwent a first allogeneic or autologous HSCT from 1998 to 2016 were included. Of the 251 HSCT recipients: 143 transplants were allogeneic and 108 were autologous...
April 20, 2018: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/29679377/clinical-characteristics-of-long-term-survival-with-non-invasive-ventilation-and-factors-affecting-the-transition-to-invasive-ventilation-in-als
#9
Takahiko Hirose, Fumiharu Kimura, Hiroki Tani, Shin Ota, Akihiro Tsukahara, Eri Sano, Taro Shigekiyo, Yoshitsugu Nakamura, Kensuke Kakiuchi, Mikiko Motoki, Kiichi Unoda, Simon Ishida, Hideto Nakajima, Shigeki Arawaka
Introduction We evaluated post non-invasive ventilation survival and factors for the transition to tracheostomy in amyotrophic lateral sclerosis. Methods We analyzed 197 patients using a prospectively-collected database, with 114 patients since 2000. Results Of 114 patients, 59 patients underwent non-invasive ventilation (NIV), which prolonged the total median survival time to 43 months compared with 32 months without treatment. The best post-NIV survival was associated with a lack of bulbar symptoms, higher measured pulmonary function, and a slower rate of progression at diagnosis...
April 20, 2018: Muscle & Nerve
https://www.readbyqxmd.com/read/29679366/blood-group-and-incidence-of-asthma-and-chronic-obstructive-pulmonary-disease
#10
Bożena Mroczek, Zygmunt Sitko, Agnieszka Sujewicz, Weronika Wolińska, Iwona Karpeta-Pawlak, Donata Kurpas
Chronic respiratory diseases are determined by genetic predisposition, and environmental and socioeconomic variables. One genetic factor underlying susceptibility to such diseases can be the ABO blood group system. The purpose of this study was to investigate the hypothesis that there would be a relationship between the blood group and risk of developing asthma and chronic obstructive pulmonary disease (COPD). We reviewed medical history files of patients with the diagnosis of COPD or asthma, including those suffering from a cancerous disease accompanied by asthma or COPD, hospitalized from January 2016 to July 2017...
April 21, 2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29679365/influence-of-gaseous-pollutants-on-copd-exacerbations-in-patients-with-cardiovascular-comorbidities
#11
Michal Zielinski, Mariusz Gasior, Dariusz Jastrzebski, Aneta Desperak, Dariusz Ziora
Exacerbations of chronic obstructive pulmonary disease (COPD) are a serious public health issue. Ambient pollution and meteorological factors are considered among precipitating factors. There are few data concerning the impact of ambient pollutants other than particulates on COPD exacerbations. Among gaseous pollutants four main groups of substances are primarily monitored: nitrogen oxides (NOx), sulphur dioxide (SO2 ), carbon monoxide (CO), and ozone (O3 ). In this study, 12,889 hospitalizations in the years 2006-2014 due to exacerbations of COPD in patients having a co-existing cardiovascular pathology were retrospectively analyzed...
April 21, 2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29679364/estimates-of-medication-expenditure-for-ischemic-heart-disease-accompanying-chronic-obstructive-pulmonary-disease
#12
Edyta Rysiak, Izabela Prokop, Ilona Zaręba, Robert M Mróz
Ischemic heart disease (IHD) is a frequent accompaniment of chronic obstructive pulmonary disease (COPD). Co-occurrence of these two diseases is associated with many risk factors, difficulties in implementing appropriate therapies, numerous complications, and high spending for treatment. All these elements significantly reduce the quality of life of patients. The aim of this study was to estimate the expenditure for medications involved with IHD pharmacotherapy in the course of COPD. This retrospective study was based on the review of medical files of 57 patients, 27 women and 30 men, diagnosed with IHD, according to the severity classification, in the course of COPD which was staged according to the GOLD criteria...
April 21, 2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29679363/proangiogenic-and-profibrotic-markers-in-pulmonary-sarcoidosis
#13
I Tuleta, L Biener, C Pizarro, G Nickenig, D Skowasch
The aim of our study was to determine the blood levels of vascular endothelial growth factor (VEGF), transforming growth factor (TGF)-β1, fibroblast growth factor (FGF)-2, and platelet-derived growth factor (PDGF)-AB in different stages of pulmonary sarcoidosis. There were 92 patients in sarcoidosis stages I + II, III, and IV enrolled into the study. All the patients underwent lung diffusing capacity and blood sampling. We found that VEGF levels differed significantly between the stage groups with the peak VEGF concentrations in stage III...
April 21, 2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29679186/impact-of-an-additional-right-pulmonary-vein-on-second-generation-cryoballoon-ablation-for-atrial-fibrillation-a-propensity-matched-score-study
#14
Ken Takarada, Erwin Ströker, Juan-Pablo Abugattas, Valentina de Regibus, Hugo-Enrique Coutiño, Ian Lusoc, Lucio Capulzini, Juan Sieira, Giacomo Mugnai, Francesca Salghetti, Rajin Choudhury, Saverio Iacopino, Carlo de Asmundis, Pedro Brugada, Gian-Battista Chierchia
PURPOSE: Cryoballoon (CB) technology in the context of anatomical pulmonary vein (PV) variants might hypothetically hamper successful PV isolation (PVI). Our aim was to assess the impact of a right middle PV (RMPV) in the setting of second-generation cryoballoon (CB advance-CB-A), on procedural parameters and on mid-term follow-up. METHODS: Consecutive patients with AF presenting RMPV (RMPV+) at the pre-procedural computed tomography who underwent PVI by CB-A were enrolled...
April 21, 2018: Journal of Interventional Cardiac Electrophysiology: An International Journal of Arrhythmias and Pacing
https://www.readbyqxmd.com/read/29679185/comparing-learning-curves-of-two-established-single-shot-devices-for-ablation-of-atrial-fibrillation
#15
Patrick Leitz, G Mönnig, F Güner, D G Dechering, K Wasmer, F Reinke, Philipp S Lange, L Eckardt, G Frommeyer
PURPOSE: We compared the contour of learning curves of two "single-shot" devices used for pulmonary vein isolation (PVI) for safety and procedural data. METHODS: We performed a retrospective analysis comparing the first 60 PVI performed at our center using a pulmonary vein ablation catheter (PVAC) array (39 male, mean age 57 years, 42 paroxysmal AF) to the first 60 first PVI using the Cryoballoon (44 male, mean age 59 years, 22 paroxysmal AF). Both groups were further divided into tertiles, where T1 regroups the first 20 ablations, T2 the following 20, and T3 the last 20 ablations...
April 20, 2018: Journal of Interventional Cardiac Electrophysiology: An International Journal of Arrhythmias and Pacing
https://www.readbyqxmd.com/read/29679171/pedicled-gastric-seromuscular-patch-for-one-stage-closure-of-a-bronchopleural-fistula-a-case-report
#16
Jun Suzuki, Hiroyuki Oizumi, Hirohisa Kato, Akira Hamada, Hikaru Watarai, Kenta Nakahashi, Takayuki Sasage, Mitsuaki Sadahiro
BACKGROUND: One-stage closure and fenestration are the available surgical options for bronchopleural fistula (BPF). One-stage closure may be applicable in cases with favorable infection control. Closing the bronchopleural stump is difficult due to thick adhesion caused by inflammation and a high risk of pulmonary artery injury. We report the successful closure of a BPF using a gastric seromuscular patch with an omental pedicle flap. CASE PRESENTATION: A 73-year-old man underwent right lower lobectomy with ND2a-2 lymph node dissection for lung adenocarcinoma...
April 20, 2018: Surgical Case Reports
https://www.readbyqxmd.com/read/29679166/composite-resection-of-the-left-upper-lobe-and-superior-segment-s6-of-the-lower-lobe-for-lung-cancer-with-a-mediastinal-lingular-and-basal-pulmonary-artery
#17
Tomoyuki Nakano, Shigemi Ishikawa, Yasunori Sohara, Shunsuke Endo
BACKGROUND: Preoperative evaluation and awareness of anatomical variations in the pulmonary vessel is essential for a secure pulmonary resection. We herein present a patient who underwent complex pulmonary resection for lung cancer with a mediastinal lingular and basal pulmonary artery that had been detected by preoperative three-dimensional computed tomography. CASE PRESENTATION: The patient was an asymptomatic 66-year-old woman who had a 39-pack-year smoking habit...
April 20, 2018: Surgical Case Reports
https://www.readbyqxmd.com/read/29679057/a-legionella-pneumophila-amylase-is-essential-for-intracellular-replication-in-human-macrophages-and-amoebae
#18
Ashley Best, Christopher Price, Mateja Ozanic, Marina Santic, Snake Jones, Yousef Abu Kwaik
Legionella pneumophila invades protozoa with an "accidental" ability to cause pneumonia upon transmission to humans. To support its nutrition during intracellular residence, L. pneumophila relies on host amino acids as the main source of carbon and energy to feed the TCA cycle. Despite the apparent lack of a requirement for glucose for L. pneumophila growth in vitro and intracellularly, the organism contains multiple amylases, which hydrolyze polysaccharides into glucose monomers. Here we describe one predicted putative amylase, LamB, which is uniquely present only in L...
April 20, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29678975/incidence-of-superficial-venous-thrombosis-in-primary-care-and-risk-of-subsequent-venous-thromboembolic-sequelae-a-retrospective-cohort-study-performed-with-routine-healthcare-data-from-the-netherlands
#19
Geert-Jan Geersing, Selma Cazemier, Frans Rutten, David A Fitzmaurice, Arno W Hoes
OBJECTIVES: Recent studies in referred populations of patients with superficial venous thrombosis (SVT) report risks of venous thromboembolic (VTE) sequelae (deep vein thrombosis or pulmonary embolism) as high as 25%. Likely, these estimates are lower in non-referred patients, but large-scale population-based studies are lacking. We aimed to estimate the incidence rate of SVT in primary care and quantify its risk of VTE sequelae. DESIGN: A retrospective cohort study, using International Classification of Primary Care coding (K94...
April 20, 2018: BMJ Open
https://www.readbyqxmd.com/read/29678906/rnai-screening-identifies-a-mechanosensitive-rock-jak2-stat3-network-central-to-myofibroblast-activation
#20
Raymond S Oh, Andrew J Haak, Karry M J Smith, Giovanni Ligresti, Kyoung Moo Choi, Tiao Xie, Shaohua Wang, Paula R Walters, Michael A Thompson, Michelle R Freeman, Logan J Manlove, Vivian M Chu, Carol Feghali-Bostwick, Anja C Roden, Jürgen Schymeinsky, Christina M Pabelick, Y S Prakash, Robert Vassallo, Daniel J Tschumperlin
Myofibroblasts play key roles in wound healing and pathologic fibrosis. Here we undertook an RNAi screen to characterize myofibroblast regulatory genes, using a high-content imaging approach to quantify alpha-smooth muscle actin stress fibers in cultured human fibroblasts. Screen hits were validated on physiological compliance hydrogels, and selected hits tested in primary fibroblasts from patients with idiopathic pulmonary fibrosis. Our RNAi screen led to the identification of STAT3 as an essential mediator of myofibroblast activation and function...
April 20, 2018: Journal of Cell Science
keyword
keyword
1593
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"