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https://www.readbyqxmd.com/read/30093507/biomarkers-for-the-diagnosis-of-venous-thromboembolism-d-dimer-thrombin-generation-procoagulant-phospholipid-and-soluble-p-selectin
#1
Nicoletta Riva, Kevin Vella, Kieron Hickey, Lorenza Bertù, Daniel Zammit, Silvana Spiteri, Steve Kitchen, Michael Makris, Walter Ageno, Alex Gatt
BACKGROUND: The diagnostic algorithm for venous thromboembolism (VTE) currently involves a composite of pre-test probability, D-dimer and imaging. Other laboratory tests, however, may assist in the identification of patients with VTE. AIM: To assess the accuracy of different coagulation tests (D-dimer, thrombin generation, phospholipid-dependent (PPL) clotting time, soluble P-selectin (sP-selectin)) as biomarkers of acute VTE. METHODS: Random samples arriving at the Coagulation Laboratory at Mater Dei Hospital (Msida, Malta) from the Accident and Emergency Department with a request for D-dimer measurement were collected between August 2015 and February 2016...
August 9, 2018: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/30073112/electrospun-polyurethane-nanofibrous-composite-impregnated-with-metallic-copper-for-wound-healing-application
#2
Saravana Kumar Jaganathan, Mohan Prasath Mani
In this study, a wound dressing based on polyurethane (PU) blended with copper sulphate nanofibers was developed using an electrospinning technique. The prepared PU and PU nanocomposites showed smooth fibers without any bead defects. The prepared nanocomposites showed smaller fiber (663 ± 156.30 nm) and pore (888 ± 70.93 nm) diameter compared to the pristine PU (fiber diameter 1159 ± 147.48 nm and pore diameter 1087 ± 62.51 nm). The interaction of PU with copper sulphate was evident in the infrared spectrum through hydrogen-bond formation...
August 2018: 3 Biotech
https://www.readbyqxmd.com/read/30064550/changes-in-plasma-protein-expression-indicative-of-early-diet-induced-metabolic-disease-in-male-pigs-sus-scrofa
#3
Marinus Fw Te Pas, Sietse-Jan Koopmans, Leo Kruijt, Sjef Boeren, Mari A Smits
Recognition of the preclinical stages of metabolic diseases such as diabetes helps to prevent full development of the disease.In our research, we alter the diet composition of pigs to create a model of human metabolic disease. The objective ofthe current study was to identify plasma proteins and biologic mechanisms that differed in expression between pigs fed a'cafeteria diet' (considered unhealthy; high in saturated fats) and those fed a 'Mediterranean diet' (considered healthy; highin unsaturated fats). Pigs fed the cafeteria diet showed increased plasma levels of proteins related to LDL ('bad cholesterol'),immune processes, blood clotting, and metal binding...
July 31, 2018: Comparative Medicine
https://www.readbyqxmd.com/read/30056255/multi-scale-characterization-and-biological-evaluation-of-composite-surface-layers-produced-under-glow-discharge-conditions-on-niti-shape-memory-alloy-for-potential-cardiological-application
#4
Adrian Chlanda, Justyna Witkowska, Jerzy Morgiel, Katarzyna Nowińska, Emilia Choińska, Wojciech Swieszkowski, Tadeusz Wierzchoń
NiTi shape memory alloys are characterized by relatively good biocompatibility primarily thanks to their ability to self-passivate. However, before they can be used as medical implants for long term use, they need to undergo treatment aimed at producing layers on their surface that are superior to spontaneously formed oxide layers and that would increase their resistance to corrosion, limit nickel ion release from the surface (metallosis) and have the capability to shape their biological properties depending on the application...
July 24, 2018: Micron: the International Research and Review Journal for Microscopy
https://www.readbyqxmd.com/read/30020797/six-year-follow-up-of-immature-tooth-revascularization-with-enamel-matrix-proteins
#5
Neidy S Corredor Gerber, Beatriz S Coelho, Tatiana M Deliberador, Darlan R Junior, Flares Baratto-Filho, Fernando LE Florez, João C Zielak, Denise P Leonardi
Novel endodontic revascularization techniques have been considered as alternative options for treatment of immature teeth affected by apical periodontitis. The continuous development of the root canal has been recognized as a major advantage of these techniques over traditional apexification approaches. This article reports a case in which endodontic revascularization using extracellular matrix proteins (EMPs) as a scaffold was utilized to treat an immature maxillary lateral incisor with history of trauma and chronic apical periodontitis...
July 2018: Compendium of Continuing Education in Dentistry
https://www.readbyqxmd.com/read/29994896/fibrinogen-and-factor-xiii-newly-recognized-roles-in-venous-thrombus-formation-and-composition
#6
Alisa S Wolberg
PURPOSE OF REVIEW: In spite of significant morbidity and mortality associated with venous thromboembolism, the underlying pathogenesis remains poorly understood. RECENT FINDINGS: Clues to operant pathogenic mechanisms are found in the unique morphology and composition of these thrombi, which have substantial red blood cell and fibrin content. Recent studies have revealed biochemical and biophysical mechanisms that dictate fibrin structure in venous thrombi and promote retention of red blood cells within the contracted clots...
September 2018: Current Opinion in Hematology
https://www.readbyqxmd.com/read/29898056/in-vitro-and-in-vivo-biocompatibility-of-reoss%C3%A2-in-powder-and-putty-configurations
#7
Andréa Vaz Braga Pintor, Rodrigo Figueiredo de Brito Resende, Adriana Terezinha Novelino Neves, Gutemberg Gomes Alves, Paulo G Coelho, José Mauro Granjeiro, Monica Diuana Calasans-Maia
This study evaluated comparatively two configurations (powder and putty) of a composite biomaterial based on PLGA (Poly(lactide-co-glycolide)/nanoescale hydroxyapatite (ReOss®, Intra-Lock International) through microscopic morphology, in vitro cytotoxicity, biocompatibility and in vivo response as a bone substitute. SEM and EDS characterized the biomaterials before/after grafting. Cytocompatibility was assessed with murine pre-osteoblasts. Osteoconductivity and biocompatibility were evaluated in White New Zealand rabbits...
March 2018: Brazilian Dental Journal
https://www.readbyqxmd.com/read/29891376/investigation-of-hepatic-warfarin-metabolism-activity-in-rodenticide-resistant-black-rats-rattus-rattus-in-tokyo-by-in-situ-liver-perfusion
#8
Kazuki Takeda, Yoshinori Ikenaka, Kazuyuki D Tanaka, Shouta M M Nakayama, Tsutomu Tanikawa, Hazuki Mizukawa, Mayumi Ishizuka
Anti-blood coagulation rodenticides, such as warfarin, have been used all over the world. They inhibit vitamin K epoxide reductase (VKOR), which is necessary for producing several blood clotting factors. This inhibition by rodenticides results in lethal hemorrhage in rodents. However, heavy usage of these agents has led to the appearance of rodenticide-resistant rats. There are two major mechanisms underlying this resistance, i.e., mutation of the target enzyme of warfarin, VKOR, and enhanced metabolism of warfarin...
June 2018: Pesticide Biochemistry and Physiology
https://www.readbyqxmd.com/read/29843918/prevalence-and-correlates-of-bleeding-and-emotional-harms-in-a-national-us-sample-of-patients-with-venous-thromboembolism-a-cross-sectional-structural-equation-model
#9
Michael Feehan, Michael Walsh, Heather Van Duker, Jon Godin, Mark A Munger, Ryan Fleming, Stacy A Johnson, Margaux A Morrison, Margaret M DeAngelis, Daniel M Witt
INTRODUCTION: Venous thromboembolism (VTE) including deep vein thrombosis (DVT) or pulmonary embolism (PE) is associated with reduced survival, poorer quality of life, and substantial health-care-costs. Limited research, primarily qualitative, suggests that those with VTE may have elevated fear of recurrence, and associated emotional dysfunction and distress. METHODS: A national online survey was administered to 907 patients who had experienced a VTE event in the past two years...
May 23, 2018: Thrombosis Research
https://www.readbyqxmd.com/read/29808843/self-assembled-bivalent-aptamers-on-graphene-oxide-as-an-efficient-anticoagulant
#10
Pei-Xin Lai, Ju-Yi Mao, Binesh Unnikrishnan, Han-Wei Chu, Chien-Wei Wu, Huan-Tsung Chang, Chih-Ching Huang
Graphene oxide (GO) has unique structural properties, can effectively adsorb single-strand DNA through π-π stacking, hydrogen bonding and hydrophobic interactions, and is useful in many biotechnology applications. In this study, we developed a thrombin-binding-aptamers (15- and 29-mer) conjugated graphene oxide (TBA15/TBA29-GO) composite for the efficient inhibition of thrombin activity towards the formation of fibrin from fibrinogen. The TBA15/TBA29-GO composite was simply obtained by the self-assembly of TBA15/TBA29 hybrids on GO...
June 25, 2018: Biomaterials Science
https://www.readbyqxmd.com/read/29803220/manufacturing-of-curd-products-of-increased-biological-value-for-the-elderly-from-dried-components
#11
Ludmila A Zabodalova, Maria S Belozerova, Tatiana N Evstigneeva
BACKGROUND: In recent years, the number of elderly people has increased, and the diseases that arise in old age are associated, amongst other factors, with malnutrition. In the elderly, the need for primary nutrients and energy changes, so the development of food products intended for this particular group of people is becom- ing increasingly important. The purpose of this research is to work out the composition of and technology for producing low-fat curd products from raw milk and vegetable components...
April 2018: Acta Scientiarum Polonorum. Technologia Alimentaria
https://www.readbyqxmd.com/read/29782513/high-red-blood-cell-composition-in-clots-is-associated-with-successful-recanalization-during-intra-arterial-thrombectomy
#12
Jong Wook Shin, Hye Seon Jeong, Hyon-Jo Kwon, Kyu Sang Song, Jei Kim
We evaluated the composition of individual clots retrieved during intra-arterial thrombectomy in relation to recanalization success, stroke subtype, and the presence of clot signs on initial brain images. We analyzed clot and interventional data from 145 retrieval trials performed for 37 patients (69.5±14.0 years, 20 men, large artery atherosclerosis, n = 7; cardioembolism, n = 22; undetermined etiology, n = 8) who had undergone intra-arterial thrombectomy. Rates of clot retrieval and successful recanalization (Arterial Occlusive Lesion score of 2-3) for separate retrieval trials were evaluated...
2018: PloS One
https://www.readbyqxmd.com/read/29778734/association-between-maximal-activated-clotting-time-and-major-bleeding-complications-during-transradial-and-transfemoral-percutaneous-coronary-intervention
#13
David W Louis, Kevin Kennedy, Fabio V Lima, Samir B Pancholy, J Dawn Abbott, Paul Gordon, Herbert D Aronow
OBJECTIVES: This study sought to determine whether higher maximal activated clotting time (ACT) during transradial (TR) percutaneous coronary intervention (PCI) is associated with greater bleeding risk. BACKGROUND: Higher maximal ACT during transfemoral (TF) PCI has been associated with a greater bleeding risk. It is unclear whether this relationship exists in the setting of TR PCI. METHODS: Among 14,637 patients undergoing TR or TF PCI with unfractionated heparin monotherapy, the study related maximal ACT to the risk of major bleeding...
June 11, 2018: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/29768672/catheter-ablation-for-atrial-fibrillation-on-uninterrupted-direct-oral-anticoagulants-a-safe-approach
#14
Vinit Sawhney, Masooma Shaukat, Elena Volkova, Nicola Jones, Rui Providencia, Shoreh Honarbakhsh, Gurpreet Dhillon, Anthony Chow, Martin Lowe, Pier D Lambiase, Mehul Dhinoja, Simon Sporton, Mark James Earley, Richard John Schilling, Ross Jacob Hunter
BACKGROUND: Current consensus guidelines suggest direct oral anticoagulants (DOACs) are interrupted periprocedurally for catheter ablation (CA) of atrial fibrillation (AF). However, this may predispose patients to thromboembolic complications. This study investigates the safety of CA for AF on uninterrupted DOACs compared to uninterrupted warfarin. METHODS: This was a single-center, retrospective study of consecutive patients undergoing CA for AF. All patients were heparinized prior to transseptal puncture with a target-activated clotting time (ACT) of 300-350 seconds...
May 16, 2018: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/29763772/graphene-kaolin-composite-sponge-for-rapid-and-riskless-hemostasis
#15
Yuping Liang, Congcong Xu, Guofeng Li, Tianchi Liu, Jun F Liang, Xing Wang
Kaolin is an effective and safe hemostatic agent for hemostasis. However, its ontic powder is difficult to use in actual practice. To develop a wieldy and powerful hemostat, composite strategy is usually a good choice. Herein, we developed a graphene-kaolin composite sponge (GKCS), synthesized with graphene oxide sheets, linker molecules and kaolin powders through a facile hydrothermal reaction. SEM observations support that GKCS has a porous structure, and EDS mapping further confirms that kaolin powders are embedded in graphene sheets...
May 8, 2018: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29758383/does-size-matter-venom-proteomic-and-functional-comparison-between-night-adder-species-viperidae-causus-with-short-and-long-venom-glands
#16
Francisco C P Coimbra, James Dobson, Christina N Zdenek, Bianca Op den Brouw, Brett Hamilton, Jordan Debono, Paul Masci, Nathaniel Frank, Lilin Ge, Hang Fai Kwok, Bryan G Fry
Night adders (Causus species within the Viperidae family) are amphibian specialists and a common source of snakebite in Africa. Some species are unique in that they have the longest venom glands of any viper, extending approximately 10% of the body length. Despite their potential medical importance and evolutionary novelty, their venom has received almost no research attention. In this study, venoms from a short-glanded species (C. lichtensteinii) and from a long-glanded species (C. rhombeatus) were compared using a series of proteomic and bioactivity testing techniques to investigate and compare the toxin composition and functioning of the venoms of these two species...
September 2018: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
https://www.readbyqxmd.com/read/29739232/comparison-of-the-coagulation-effect-achieved-by-octaplaslg-versus-fresh-frozen-plasma-in-pediatric-cardiac-surgical-patients
#17
Amanpreet S Kalsi, Omar Al-Azzawi, Ravi Gill
OctaplasLG is indicated for use in patients undergoing cardiac surgery who require replacement of multiple clotting factors. The use of OctaplasLG over single-donor fresh frozen plasma (FFP) may have beneficial effects when considering the transmission of enveloped viruses. Additionally, it has the potential for fewer adverse reactions, reduced disease transmission, and a more homogenous coagulation factor composition. However, its efficacy and safety have not yet been evaluated in the pediatric population...
January 1, 2018: Clinical and Applied Thrombosis/hemostasis
https://www.readbyqxmd.com/read/29733637/anticoagulant-properties-of-poly-sodium-2-acrylamido-2-methylpropanesulfonate-based-di-and-triblock-polymers
#18
Bartlomiej Kalaska, Kamil Kamiński, Joanna Miklosz, Keita Nakai, Shin-Ichi Yusa, Dariusz Pawlak, Maria Nowakowska, Andrzej Mogielnicki, Krzysztof Szczubiałka
Di- and triblock copolymers with low dispersity of molecular weight were synthesized using radical addition-fragmentation chain transfer polymerization. The copolymers contained anionic poly(sodium 2-acrylamido-2-methylpropanesulfonate) (PAMPS) block as an anticoagulant component. The block added to lower the toxicity was either poly(ethylene glycol) (PEG) or poly(2-(methacryloyloxy)ethyl phosphorylcholine) (PMPC). The polymers prolonged clotting times both in vitro and in vivo. The influence of the polymer architecture and composition on the efficacy of anticoagulation and safety parameters was evaluated...
July 9, 2018: Biomacromolecules
https://www.readbyqxmd.com/read/29729992/proteomics-functional-characterization-and-antivenom-neutralization-of-the-venom-of-pakistani-russell-s-viper-daboia-russelii-from-the-wild
#19
Tasnim Faisal, Kae Yi Tan, Si Mui Sim, Naeem Quraishi, Nget Hong Tan, Choo Hock Tan
The venom proteome of wild Pakistani Russell's viper (Daboia russelii) was investigated through nano-ESI-LCMS/MS of the reverse-phase HPLC fractions. A total of 54 venom proteins were identified and clustered into 11 protein families. Phospholipase A2 (PLA2 , 63.8%) and Kunitz-type serine protease inhibitor (KSPI, 16.0%) were most abundant, followed by snake venom serine protease (SVSP, 5.5%, mainly Factor V activating enzyme), vascular endothelial growth factor (VEGF, 4.3%), snake venom metalloproteinase (SVMP, 2...
July 15, 2018: Journal of Proteomics
https://www.readbyqxmd.com/read/29719836/ability-of-polyphosphate-and-nucleic-acids-to-trigger-blood-clotting-some-observations-and-caveats
#20
Stephanie A Smith, Joshua M Gajsiewicz, James H Morrissey
Polyphosphate plays several roles in coagulation and inflammation, while extracellular DNA and RNA are implicated in thrombosis and as disease biomarkers. We sought to compare the procoagulant activities of polyphosphate versus DNA or RNA isolated from mammalian cells. In a recent study, we found that much of the procoagulant activity of DNA isolated from mammalian cells using Qiagen kits resisted digestion with nuclease or polyphosphatase, and even resisted boiling in acid. These kits employ spin columns packed with silica, which is highly procoagulant...
2018: Frontiers in Medicine
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