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C Chillemi, L Dei Giudici, M Mantovani, M Osimani, S Gumina
BACKGROUND: Tear recurrence is considered the main complication of a rotator cuff repair. The best arthroscopic technique has not yet been established. The aim of the present study was to evaluate, from a clinical and a radiological standpoint, the all-arthroscopic transosseous rotator cuff repair with cortical lateral augmentation, performed in the setting of a revision surgery. MATERIALS AND METHODS: Eleven consecutive cases were prospectively followed up for a minimum of 12 month after a rotator cuff repair with a novel all-arthroscopic transosseous rotator cuff repair...
October 2018: Musculoskeletal Surgery
Juhyun Hong, Seong-Hee Park, Sujin Kim, Seon-Won Kim, Ji-Sook Hahn
Lycopene is a red carotenoid pigment with strong antioxidant activity. Saccharomyces cerevisiae is considered a promising host to produce lycopene, but lycopene toxicity is one of the limiting factors for high-level production. In this study, we used heterologous lycopene biosynthesis genes crtE and crtI from Xanthophyllomyces dendrorhous and crtB from Pantoea agglomerans for lycopene production in S. cerevisiae. The crtE, crtB, and crtI genes were integrated into the genome of S. cerevisiae CEN.PK2-1C strain, while deleting DPP1 and LPP1 genes to inhibit a competing pathway producing farnesol...
October 20, 2018: Applied Microbiology and Biotechnology
Jessica Bear, Natalie Rollick, David Helfet
PURPOSE OF REVIEW: Tibial plafond, or pilon, fractures can be some of the most difficult fractures to manage. As they are often associated with high-energy trauma, both the soft tissue involvement and the comminuted fracture pattern pose challenges to fixation. Furthermore, the complex anatomy and trauma to the cartilage at the time of injury predispose pilon fractures to poor functional outcomes and high rates of posttraumatic arthritis. This review will discuss the recent developments in the treatment of tibial pilon fractures...
October 20, 2018: Current Reviews in Musculoskeletal Medicine
Andrea Giannetti, Marco Matergi, Marco Biscontri, Francesco Tedone, Lucia Falconi, Luca Giovannelli, Valeria Ussia, Luca Franci
Strain elastography is a recently developed ultrasound method that seems to contribute to the diagnosis and monitoring of inflammatory bowel diseases. This pictorial essay aims to present the feasibility of strain elastography in clinical practice by comparing visual observation and semiquantitative parameters with endoscopic or radiological images in some common cases of Crohn's disease. In our opinion, strain elastography with visual observation is easily performed in connection with B-mode ultrasound and color Doppler imaging and may provide relevant information...
October 20, 2018: Journal of Ultrasound
Yongfeng Jin, Hao Li
The complexity of neuronal wiring relies on the extraordinary recognition diversity of cell surface molecules. Drosophila Dscam1 and vertebrate clustered protocadherins (Pcdhs) are two classic examples of the striking diversity from a complex genomic locus, wherein the former encodes more than 10,000 distinct isoforms via alternative splicing, while the latter employs alternative promoters to attain isoform diversity. These structurally unrelated families show remarkably striking molecular parallels and even similar functions...
October 20, 2018: Cellular and Molecular Life Sciences: CMLS
Lionel El Khoury, Rosa Benvenga, Rodolfo Romero, Regis Cohen, Joel Roussel, Jean-Marc Catheline
INTRODUCTION: Sleeve gastrectomy (SG) has become one of the most dramatically increasing bariatric procedures worldwide due to its excellent results and impact on the obesity pandemic. Morbid obesity is known to increase the risk of esophageal adenocarcinoma. However, the evolution of gastroesophageal reflux disease (GERD) along with Barrett's esophagus (BE) after SG is of concern since there is little data available. We present a case of esophageal adenocarcinoma after SG with known intestinal metaplasia on preoperative gastroscopy...
October 12, 2018: International Journal of Surgery Case Reports
Russell D C Bicknell, Katie S Collins, Martin Crundwell, Michael Hannah, James S Crampton, Nicolás E Campione
The fossil record provides empirical patterns of morphological change through time and is central to the study of the tempo and mode of evolution. Here we apply likelihood-based time-series analyses to the near-continuous fossil record of Neogene planktonic foraminifera and reveal a morphological shift along the Truncorotalia lineage. Based on a geometric morphometric dataset of 1,459 specimens, spanning 5.9-4.5 Ma, we recover a shift in the mode of evolution from a disparate latest Miocene morphospace to a highly constrained early Pliocene morphospace...
October 1, 2018: iScience
Ndivhuho A Makhado, Edith Matabane, Mauro Faccin, Claire Pinçon, Agathe Jouet, Fairouz Boutachkourt, Léonie Goeminne, Cyril Gaudin, Gugu Maphalala, Patrick Beckert, Stefan Niemann, Jean-Charles Delvenne, Michel Delmée, Lufuno Razwiedani, Maphoshane Nchabeleng, Philip Supply, Bouke C de Jong, Emmanuel André
BACKGROUND: Global roll-out of rapid molecular assays is revolutionising the diagnosis of rifampicin resistance, predictive of multidrug-resistance, in tuberculosis. However, 30% of the multidrug-resistant (MDR) strains in an eSwatini study harboured the Ile491Phe mutation in the rpoB gene, which is associated with poor rifampicin-based treatment outcomes but is missed by commercial molecular assays or scored as susceptible by phenotypic drug-susceptibility testing deployed in South Africa...
October 17, 2018: Lancet Infectious Diseases
Bharath Raj Madhanagopal, Shunqing Zhang, Esra Demirel, Heitham Wady, Arun Richard Chandrasekaran
Simple base-pairing rules of complementarity, perfected by evolution for encoding genetic information, provide unprecedented control over the process of DNA self-assembly. These rules allow us to build exquisite nanostructures and rationally design their morphology, fine-tune their chemical properties, and program their response to environmental stimuli. DNA nanostructures have emerged as promising candidates for transporting drugs across various physiological barriers of the body. In this review, we discuss the strategies used to transform DNA nanostructures into drug delivery vehicles...
October 17, 2018: Trends in Biochemical Sciences
Yeh-Sheng Chien, Shu-Ting Luo, Kuo-Chien Tsao, Ying-Hsiang Wang, Tzou-Yien Lin, Yhu-Chering Huang, Min-Shi Lee
North America experienced life-threatening outbreaks of enterovirus D68 (EV-D68) in 2014. We retrospectively detected EV-D68 from a child with Wilson's disease in 2008 in Taiwan. After comparing this EV-D68/Taiwan/2008 strain with EV-D68 genomes obtained from the public domain, it was classified as genome type 1-B; it is phylogenetically related to the predominant EV-D68 viruses that circulated in 2009 in Vietnam. It is necessary to strengthen EV-D68 detection globally, including in children with acute liver failure...
October 18, 2018: Journal of the Formosan Medical Association, Taiwan Yi Zhi
Shahneela Mazhar, Colin Hill, Olivia McAuliffe
The Gram-positive genus Macrococcus is composed of eight species that are evolutionarily closely related to species of the Staphylococcus genus. In contrast to Staphylococcus species, species of Macrococcus are generally regarded to be avirulent in their animal hosts. Recent reports on Macrococcus have focused on the presence of novel methicillin resistance genes in Macrococcus caseolyticus and Macrococcus canis, with the discovery of the first plasmid-encoded methicillin resistance gene in clinical Staphylococcus aureus of probable macrococcal origin generating further interest in these organisms...
2018: Advances in Applied Microbiology
Carlos Sáez, Juan M García-Gómez
AIM: The increasing availability of Big Biomedical Data is leading to large research data samples collected over long periods of time. We propose the analysis of the kinematics of data probability distributions over time towards the characterization of data temporal variability. METHODS: First, we propose a kinematic model based on the estimation of a continuous data temporal trajectory, using Functional Data Analysis over the embedding of a non-parametric statistical manifold which points represent data temporal batches, the Information Geometric Temporal (IGT) plot...
November 2018: International Journal of Medical Informatics
Vanessa Cristina Meira De Amorim, Markley Silva Oliveira Júnior, Eduardo Muniz Santana Bastos, Victor Diogenes Amaral Da Silva, Silvia Lima Costa
PURPOSE: Flavonoids are a group of secondary metabolites of the polyphenols class present in several plant species. Among them, the biflavonoid agathisflavone is of interest since it bears several biological effects that include: antiviral, antitumoral, antiprotozoal and neurogenic actions. In this sense, this study aims to use the important tool of scientific prospecting to assess the level of research development concerning the flavonoid agathisflavone. METHODS: The experimental design was carried out through strategic reach with keywords on the PubMed (National Center for Biotechnology Information - NCBI) and Science Direct platforms...
2018: Journal of Pharmacy & Pharmaceutical Sciences: a Publication of the Canadian Society for Pharmaceutical Sciences
Joe Turner, Ritesh Krishna, Arjen E Van't Hof, Elizabeth R Sutton, Kelly Matzen, Alistair C Darby
BACKGROUND: Aedes aegypti is the principal vector of several important arboviruses. Among the methods of vector control to limit transmission of disease are genetic strategies that involve the release of sterile or genetically modified non-biting males, which has generated interest in manipulating mosquito sex ratios. Sex determination in Ae. aegypti is controlled by a non-recombining Y chromosome-like region called the M locus, yet characterisation of this locus has been thwarted by the repetitive nature of the genome...
October 20, 2018: Parasites & Vectors
Deli Jiang, Baowei Wen, Yuqi Zhang, Yu Jin, Di Li, Min Chen
Semiconductor-based photocatalytic hydrogen evolution through water splitting is of great importance for tacking the ever-increasing energy concerns. Here, novel visible-light-driven MoS2 /SnNb2 O6 2D/2D nanosheet heterojunction for photocatalytic hydrogen evolution was designed and fabricated by a facile hydrothermal method. The as-prepared 2D/2D heterojunctions not only offer extended visible light absorption range but also accelerate the separation and transfer efficiency of charge carriers owing to the typical 2D interface...
October 12, 2018: Journal of Colloid and Interface Science
Marta Jiménez-Salcedo, Miguel Monge, María Teresa Tena
The photocatalytic degradation of ibuprofen with TiO2 nanoparticles (NPs) and UV light and with graphitic carbon nitride (g-C3 N4 ) 2D nanosheets and visible light are proposed and compared as advanced oxidation treatments for the removal of ibuprofen in water. By-products formed with both photocatalytic systems have been tentatively identified based on the results of ultra-high-performance liquid chromatography coupled to high-resolution mass spectrometry, using a quadrupole-time of flight mass spectrometer in positive and negative ionization modes, which allowed to obtain the elementary composition of their precursors and fragment ions...
October 9, 2018: Chemosphere
Victor Smetacek
Terrestrial ecologists and biogeochemists are in direct contact with their objects of study via sense organs evolved in those environments; they hence share a common awareness because they can all see the whole elephant, as in the ancient Indian parable. Pelagic ecologists and biogeochemists on the other hand are the blind men groping different parts of the elephant - the protist-dominated biome of the planet - in attempts to understand its structure and functioning in terms of organism life cycles and the biogenic elements of which they are made...
August 27, 2018: Protist
Jiawei Wen, Pengge Ning, Hongbin Cao, He Zhao, Zhi Sun, Yi Zhang
Identification the polymerization nature of vanadium bearing solution is difficult, yet it is of great environmental concern due to the possible carcinogenic effects as well as high-value sustainable necessities. Thus, seeking for simple and efficient characterization methods of tracking vanadium species is in urgent demand. In this work, high-resolution electrospray ionization time-of-flight mass spectrometry (ESI-TOF-MS) coupled with thermodynamic calculations was employed to measure vanadium-containing samples...
September 29, 2018: Journal of Hazardous Materials
Juan Ignacio Arraras, Ana Manterola, Jose Juan Illarramendi, Gemma Asin, Susana de la Cruz, Berta Ibañez, Arkaitz Galbete, Esteban Salgado, Uxue Zarandona, Ruth Vera, Miguel Angel Dominguez, Enrique Martinez
No abstract text is available yet for this article.
October 17, 2018: Breast: Official Journal of the European Society of Mastology
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