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Gisèle Carrière, Claudia Sanmartin, Patricia Murison
BACKGROUND: National population information about the surgical treatment rate for primary cancers, including breast cancer, has remained a significant data gap in Canada. This gap has implications for cancer care planning and evaluating health system performance. New linkages between the Canadian Cancer Registry and hospital discharge records were conducted by Statistics Canada in 2016. Using already existing, routinely collected health administrative data, these linkages allow viable reporting of surgical cancer treatment for the first time for all provinces and territories (except Quebec)...
August 15, 2018: Health Reports
Joseph L Wilson, Bridgid H Wilson, Justin R Edwards
No abstract text is available yet for this article.
August 2018: Journal of Family Practice
Laura Luque-Sastre, Edward M Fox, Kieran Jordan, Séamus Fanning
Listeria species are ubiquitous in nature and can adapt to survive in a variety of niches, including food processing environments. Listeria species that colonize these environments may also have the potential to persist. Food safety strategies designed to manage these niches include regular cleaning and disinfection with proven sanitizers containing biocide-active compounds. Typically, these sanitizers are effective against bacteria growing under planktonic conditions, but their efficacy may be compromised when bacteria are contained in biofilms...
August 15, 2018: Journal of Food Protection
Henry J Whittle, Lila A Sheira, Edward A Frongillo, Kartika Palar, Jennifer Cohen, Daniel Merenstein, Tracey E Wilson, Adebola Adedimeji, Mardge H Cohen, Adaora A Adimora, Ighovwerha Ofotokun, Lisa Metsch, Janet M Turan, Eryka L Wentz, Phyllis C Tien, Sheri D Weiser
BACKGROUND AND AIMS: Few longitudinal studies have examined the relationship between food insecurity and substance use. We aimed to investigate this relationship using longitudinal data among women with or at risk for HIV in the United States. DESIGN: Women's Interagency HIV Study (WIHS), a prospective cohort study. SETTING: Nine sites across the US. PARTICIPANTS: 2,553 women with or at risk for HIV. MEASUREMENTS: Semi-annual structured interviews were conducted during April 2013-March 2016...
August 14, 2018: Addiction
Mark Edward Packer
Movement disorders encompass a wide range of medical conditions that demonstrate changes to muscle function and tone which present with orofacial dyskinesia and dystonia. The most common conditions exhibiting these features are Parkinson's disease, Down syndrome, chorea and epilepsy. AIM: To establish whether implant success in patients suffering from movement disorders is similar to the general population, identifying risk factors and noting recommendations that may aid maintenance programmes...
2018: European Journal of Oral Implantology
Andrew Mark Edwards, Lia Dutton-Challis, David Cottrell, Joshua H Guy, Florentina Johanna Hettinga
Objective: The positive effect of an audience on performance is anecdotally well known, but the impact of such social facilitation to both performance and the motivation to exercise have not been thoroughly explored. The aim of this study was therefore to investigate verbal encouragement as a means to promote positive behavioural adherence to exercise and augmented performance. Methods: Twelve untrained but active individuals (seven female), age 24±3 years participated in this study...
2018: BMJ Open Sport & Exercise Medicine
Marina P Savić, Jovana J Ajduković, Jovana J Plavša, Sofija S Bekić, Andjelka S Ćelić, Olivera R Klisurić, Dimitar S Jakimov, Edward T Petri, Evgenija A Djurendić
New A-ring pyridine fused androstanes in 17a-homo-17-oxa (d-homo lactone), 17α-picolyl or 17( E )-picolinylidene series were synthesized and validated by X-ray crystallography, HRMS, IR and NMR spectroscopy. Novel compounds 3 , 5 , 8 and 12 were prepared by treatment of 4-en-3-one or 4-ene-3,6-dione d-modified androstane derivatives with propargylamine catalyzed by Cu(ii), and evaluated for potential anticancer activity in vitro using human cancer cell lines and recombinant targets of steroidal anti-cancer drugs...
June 1, 2018: MedChemComm
Min Li, Yancun Fan, Edward B McNeil, Virasakdi Chongsuvivatwong
Background: In Inner Mongolia of China, traditional Mongolian medicine (TMM), traditional Chinese medicine (TCM), and western medicine (WM) are all supported by the government. This study compares the background and performance of these three types of medicines. Methods: The World Health Organization's Six Building Blocks framework was used for the system review. Data were collected from literature review and key informant interviews. A cross-sectional survey was conducted in three types of hospitals at the provincial, municipal (city), and prefectural (county) levels from April to August, 2016...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
Vincent I O Agyapong, Marianne Hrabok, Michal Juhas, Joy Omeje, Edward Denga, Bernard Nwaka, Idowu Akinjise, Sandra E Corbett, Shahram Moosavi, Matthew Brown, Pierre Chue, Andrew J Greenshaw, Xin-Min Li
The Fort McMurray wildfire was the costliest disaster in Canadian history, with far-reaching impacts. The purpose of this paper is to examine the prevalence and risk factors of elevated generalized anxiety disorder (GAD) symptomatology in residents of Fort McMurray 6 months after the wildfire. Data were collected via random selection procedures from 486 participants. Generalized anxiety disorder symptoms were measured via the GAD-7. The 1-month prevalence rate for GAD symptomatology 6 months after the disaster was 19...
2018: Frontiers in Psychiatry
Qazi Mumtaz Ahmad, Akmal Laeeq Chishti, Nayyab Waseem
OBJECTIVE: To find out the effect of melatonin as adjunct therapy on outcome of admitted newborns presenting with hypoxic ischaemic encephalopathy. METHODS: This randomized controlled trial was conducted at King Edward Medical University, Lahore, Pakistan, from October 2016 to March 2017, and comprised newborns with gestational age of 34 weeks or higher who fulfilled the definition of hypoxic ischaemic encephalopathy and presented within 12 hours of birth. The severity of hypoxic ischaemic encephalopathy was assessed by Thompson score...
August 2018: JPMA. the Journal of the Pakistan Medical Association
Tonya N Watkins, Teclegiorgis Gebremariam, Marc Swidergall, Amol C Shetty, Karen T Graf, Abdullah Alqarihi, Sondus Alkhazraji, Abrar I Alsaadi, Vonetta L Edwards, Scott G Filler, Ashraf S Ibrahim, Vincent M Bruno
Mucormycosis is a life-threatening, invasive fungal infection that is caused by various species belonging to the order Mucorales. Rhizopus species are the most common cause of the disease, responsible for approximately 70% of all cases of mucormycosis. During pulmonary mucormycosis, inhaled Rhizopus spores must adhere to and invade airway epithelial cells in order to establish infection. The molecular mechanisms that govern this interaction are poorly understood. We performed an unbiased survey of the host transcriptional response during early stages of Rhizopus arrhizus var...
August 14, 2018: MBio
Roser Pinyol, Robert Montal, Laia Bassaganyas, Daniela Sia, Tadatoshi Takayama, Gar-Yang Chau, Vincenzo Mazzaferro, Sasan Roayaie, Han Chu Lee, Norihiro Kokudo, Zhongyang Zhang, Sara Torrecilla, Agrin Moeini, Leonardo Rodriguez-Carunchio, Edward Gane, Chris Verslype, Adina Emilia Croitoru, Umberto Cillo, Manuel de la Mata, Luigi Lupo, Simone Strasser, Joong-Won Park, Jordi Camps, Manel Solé, Swan N Thung, Augusto Villanueva, Carol Pena, Gerold Meinhardt, Jordi Bruix, Josep M Llovet
OBJECTIVE: Sorafenib is the standard systemic therapy for advanced hepatocellular carcinoma (HCC). Survival benefits of resection/local ablation for early HCC are compromised by 70% 5-year recurrence rates. The phase 3 STORM trial comparing sorafenib with placebo as adjuvant treatment did not achieve its primary endpoint of improving recurrence-free survival (RFS). The biomarker companion study BIOSTORM aims to define (A) predictors of recurrence prevention with sorafenib and (B) prognostic factors with B level of evidence...
August 14, 2018: Gut
Edward A Motea, Farjana J Fattah, Ling Xiao, Luc Girard, Amy Rommel, Julio C Morales, Praveen Patidar, Yunyun Zhou, Andrew Porter, Yang Xie, John D Minna, David A Boothman
PURPOSE: Identification of novel strategies to expand the use of PARP inhibitors beyond BRCA deficiency is of great interest in personalized medicine. Here, we investigated the unannotated role of Kub5-HeraRPRD1B in homologous recombination (HR) repair and its potential clinical significance in targeted cancer therapy. EXPERIMENTAL DESIGN: Functional characterization of K-H alterations on HR repair of double-strand breaks (DSB) were assessed by targeted gene silencing, plasmid reporter assays, immunofluorescence and Western blots...
August 14, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
Robert J Rounbehler, Anders E Berglund, Travis Gerke, Mandeep M Takhar, Shivanshu Awasthi, Weimin Li, Elai Davicioni, Nicholas G Erho, Ashley E Ross, Edward M Schaeffer, Eric A Klein, R Jeffrey Karnes, Robert B Jenkins, John L Cleveland, Jong Y Park, Kosj Yamoah
BACKGROUND: We studied the utility of the tumor suppressor Tristetraprolin (TTP, ZFP36) as a clinically relevant biomarker of aggressive disease in prostate cancer patients after radical prostatectomy (RP). METHODS: TTP RNA expression was measured in an RP cohort of patients treated at Moffitt Cancer Center (MCC) and obtained from six publically available RP datasets with biochemical recurrence (BCR) (total n=1,394) and/or metastatic outcome data (total n=1,222)...
August 14, 2018: Cancer Epidemiology, Biomarkers & Prevention
C Edward Watkins
Adapting the therapeutic pyramid to the supervision of psychotherapy, the author presents and describes the supervision pyramid-a simple meta-model of the broad conceptual organizers of the supervisor's contribution to the experience and outcomes of supervision. The supervision pyramid consists of three commonalities: supervisor skills and interventions, the supervisory relationship, and the supervisor's person and personhood. Those three commonalities converge to stimulate supervisee learning and relearning and client improvement and symptom reduction...
August 15, 2018: American Journal of Psychotherapy
Erik Snesrud, Patrick McGann, Edward Walsh, Ana Ong, Rosslyn Maybank, Yoon Kwak, Jean Campbell, Anthony Jones, Kelly Vore, Mary Hinkle, Emil Lesho
Elizabethkingia spp are Gram-negative bacteria associated with neonatal meningitis. In 2015-2016, an outbreak of Elizabethkingia anophelis infection that involved 63 patients and 18 deaths occurred in Wisconsin. Despite a multistate investigation, as of September 2016 the source remained undetermined, and experts warned of reemergence. We describe here the first cases of E anophelis infection in New York, including the case of a healthy infant without previous healthcare contact.
August 10, 2018: Journal of the Pediatric Infectious Diseases Society
Robert A Dobie, William W Clark, Dorina Kallogjeri, Edward L Spitznagel
No abstract text is available yet for this article.
August 11, 2018: Annals of Work Exposures and Health
Youn Ok Lee, Antonio A Morgan-Lopez, James M Nonnemaker, Jessica K Pepper, Edward C Hensel, Risa J Robinson
Introduction: Delivery of nicotine and substances from electronic nicotine delivery systems, or e-cigarettes, depends in-part on how users puff on the devices. Little is known about variation in puffing behavior to inform testing protocols or understand if puffing behaviors result in increased exposure to emissions. Methods: We analyzed puff topography data collected using a wireless portable use monitor (wPUMTM) continuously over 2 weeks among N = 34 current second generation ecigarette users in their everyday lives...
August 10, 2018: Nicotine & Tobacco Research: Official Journal of the Society for Research on Nicotine and Tobacco
Gururaj Shivange, Karol Urbanek, Piotr Przanowski, Justin S A Perry, James Jones, Robert Haggart, Christina Kostka, Tejal Patki, Edward Stelow, Yuliya Petrova, Danielle Llaneza, Marty Mayo, Kodi S Ravichandran, Charles N Landen, Sanchita Bhatnagar, Jogender Tushir-Singh
Therapeutic antibodies targeting ovarian cancer (OvCa)-enriched receptors have largely been disappointing due to limited tumor-specific antibody-dependent cellular cytotoxicity. Here we report a symbiotic approach that is highly selective and superior compared with investigational clinical antibodies. This bispecific-anchored cytotoxicity activator antibody is rationally designed to instigate "cis" and "trans" cytotoxicity by combining specificities against folate receptor alpha-1 (FOLR1) and death receptor 5 (DR5)...
August 13, 2018: Cancer Cell
Sitai Liang, Edward A Medina, Boajie Li, Samy L Habib
Loss of Von Hippel-Lindau (VHL) in renal carcinoma cells results in up regulation of the activity of Hypoxia-Inducible Factor (HIF-α), a major transcription factor involved in kidney cancer. Rapamycin as mTOR inhibitor and 5-aminoimidazole-4-carboxamide (AICA)-riboside (AICAR) as AMPK activator are separately used to treat cancer patients. In the current study, the possible additive effect of drug combinations in reducing kidney tumorigenesis was investigated. Treatment with drug combinations significantly decreased cell proliferation, increased cell apoptosis, and abolished Akt phosphorylation and HIF-2α expression in RCC cells, including primary cells isolated from kidney cancer patients...
August 14, 2018: Molecular Oncology
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