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https://www.readbyqxmd.com/read/30342370/a-versatile-custom-cryostat-for-dynamic-nuclear-polarization-supports-multiple-cryogenic-magic-angle-spinning-transmission-line-probes
#1
Faith J Scott, Nicholas Alaniva, Natalie C Golota, Erika L Sesti, Edward P Saliba, Lauren E Price, Brice J Albert, Pinhui Chen, Robert D O'Connor, Alexander B Barnes
Dynamic nuclear polarization (DNP) with cryogenic magic angle spinning (MAS) provides significant improvements in NMR sensitivity, yet presents unique technical challenges. Here we describe a custom cryostat and suite of NMR probes capable of manipulating nuclear spins with multi-resonant radiofrequency circuits, cryogenic spinning below 6 K, sample exchange, and microwave coupling for DNP. The corrugated waveguide and six transfer lines needed for DNP and cryogenic spinning functionality are coupled to the probe from the top of the magnet...
October 3, 2018: Journal of Magnetic Resonance
https://www.readbyqxmd.com/read/30342109/worthy-of-further-consideration-an-updated-meta-analysis-to-address-the-feasibility-acceptability-safety-and-efficacy-of-thermal-ablation-in-the-treatment-of-cervical-cancer-precursor-lesions
#2
REVIEW
Thomas C Randall, Catherine Sauvaget, Richard Muwonge, Edward L Trimble, Jose Jeronimo
Treatment of preinvasive lesions is critical to the success of secondary prevention of cervical cancer. In many settings, however, excision or ablation of preinvasive lesions can prove challenging. Thermal ablation (TA) is a form of treatment for cervical precancer that may present fewer logistical challenges in resource limited settings. In 2013, Dolman and colleagues wrote a meta-analysis of publications reporting cure rates from TA. This included only one article from a low or middle-income country (LMIC)...
October 17, 2018: Preventive Medicine
https://www.readbyqxmd.com/read/30342095/highly-pathogenic-avian-influenza-h5n8-clade-2-3-4-4b-virus-in-uganda-2017
#3
Deo Ndumu, Bianca Zecchin, Alice Fusaro, Eugene Arinaitwe, Richard Erechu, Eugene Kidega, John Kayiwa, Edward Muwanga, Mukasa Kirumira, Gerald Kirembe, Julius Lutwama, Isabella Monne
In early January 2017, outbreaks of H5N8 highly pathogenic avian influenza (HPAI) were reported for the first time in wild and domestic birds along the shores and on some islands of Lake Victoria, in central-southern Uganda. Our whole-genome phylogenetic analyses revealed that the H5N8 viruses recovered from the outbreak in Uganda belonged to genetic clade 2.3.4.4 group-B and clustered with viruses collected in 2017 in the Democratic Republic of the Congo and in West Africa. Our results suggested that infected migratory wild birds might have played a crucial role in the introduction of HPAI H5N8 into this region...
October 17, 2018: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/30341969/novel-implementation-of-genotype-guided-proton-pump-inhibitor-medication-therapy-in-children-a-pilot-randomized-multisite-pragmatic-trial
#4
Emily J Cicali, Kathryn Blake, Yan Gong, Edward B Mougey, Hadeel Al-Atrash, Nancy Chambers, Jolanda Denham, Jonathan Evans, Donald E George, Roberto Gomez, Pablo Palomo, Salik Taufiq, Julie A Johnson, John J Lima, James P Franciosi
The efficacy of proton pump inhibitor (PPI) medications is highly dependent on plasma concentrations, which varies considerably due to cytochrome P450 (CYP2C19) genetic variation. We conducted a pragmatic, pilot study of CYP2C19 genotype-guided pediatric dosing of PPI medications. Children aged 5-17 years old with gastric-acid-related conditions were randomized to receive either conventional dosing of a PPI or genotype-guided dosing for a total of 12 weeks. Sixty children (30 in each arm) were enrolled and had comparable baseline characteristics...
October 20, 2018: Clinical and Translational Science
https://www.readbyqxmd.com/read/30341949/the-earlier-the-better-pausing-for-thought-%C3%A2
#5
Barbara Maughan, Edward D Barker
Is earlier intervention always superior? Using two complementary forms of meta-analysis, Gardner and colleagues find no support for the "earlier is better" hypothesis in outcomes of parenting programs for child behavior problems across the 2-11 year age range. This commentary explores possible methodological and substantive reasons for the pattern of their findings. We need additional careful analyses of this kind, assessing age variations in intervention effects across broader age ranges, and in other developmental domains, for strong tests of the "earlier is better" hypothesis...
October 20, 2018: Child Development
https://www.readbyqxmd.com/read/30341807/radiological-appearance-of-coal-mine-dust-lung-diseases-in-australian-workers
#6
Rhiannon McBean, Katrina Newbigin, Shannan Dickinson, Robert Edwards
Coal Mine Dust Lung Disease (CMDLD) encompasses a spectrum of lung diseases caused by prolonged exposure to coal mine dust. This review presents high-resolution computed tomography (HRCT) images from men diagnosed with a CMDLD since the resurgence of these diseases in Queensland in 2015.
October 19, 2018: Journal of Medical Imaging and Radiation Oncology
https://www.readbyqxmd.com/read/30341612/induction-of-cu-zn-superoxide-dismutase-sod1-aggregation-in-living-cells
#7
Edward Pokrishevsky, Jeremy Nan, Neil R Cashman
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by progressive degeneration and loss of motor neurons that appears to spread through the neuroaxis in a spatiotemporally restricted manner. In the familial form of ALS, the presence of any one of over 180 inherited mutations in the gene that encodes Cu/Zn superoxide dismutase (SOD1) leads to its eventual misfolding and aggregation. Once the pathological SOD1 seed is formed, it can continue growing into a larger aggregate through nucleation of other SOD1 substrate molecules...
2019: Methods in Molecular Biology
https://www.readbyqxmd.com/read/30341561/rib-fixation-versus-non-operative-treatment-for-flail-chest-and-multiple-rib-fractures-after-blunt-thoracic-trauma-a-multicenter-cohort-study
#8
Reinier B Beks, David Reetz, Mirjam B de Jong, Rolf H H Groenwold, Falco Hietbrink, Michael J R Edwards, Luke P H Leenen, Roderick Marijn Houwert, Jan Paul M Frölke
BACKGROUND: Over the years, a trend has evolved towards operative treatment of flail chest although evidence is limited. Furthermore, little is known about operative treatment for patients with multiple rib fractures without a flail chest. The aim of this study was to compare rib fixation based on a clinical treatment algorithm with nonoperative treatment for both patients with a flail chest or multiple rib fractures. METHODS: All patients with ≥ 3 rib fractures admitted to one of the two contributing hospitals between January 2014 and January 2017 were retrospectively included in this multicenter cohort study...
October 19, 2018: European Journal of Trauma and Emergency Surgery: Official Publication of the European Trauma Society
https://www.readbyqxmd.com/read/30341499/pharmacokinetics-and-safety-of-glecaprevir-and-pibrentasvir-in-hcv-negative-subjects-with-hepatic-impairment
#9
Matthew P Kosloski, Haoyu Wang, David Pugatch, Federico J Mensa, Edward Gane, Eric Lawitz, Thomas C Marbury, Richard A Preston, Jens Kort, Wei Liu
PURPOSE: This study characterized the effects of hepatic impairment on the pharmacokinetics and safety of glecaprevir and pibrentasvir, two direct-acting antivirals used for treatment of chronic HCV infection. METHODS: HCV-negative subjects with normal hepatic function, or with mild (Child-Pugh [CP]-A), moderate (CP-B), or severe (CP-C) hepatic impairment received single doses of pibrentasvir 120 mg alone or with glecaprevir 200 mg or 300 mg (n = 6/functional group/dose)...
October 19, 2018: European Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/30341136/asymptomatic-malaria-parasitaemia-and-seizure-control-in-children-with-nodding-syndrome-a-cross-sectional-study
#10
Rodney Ogwang, Ronald Anguzu, Pamela Akun, Albert Ningwa, Edward Kayongo, Kevin Marsh, Charles R J C Newton, Richard Idro
OBJECTIVE: Plasmodium falciparum is epileptogenic and in malaria endemic areas, is a leading cause of acute seizures. In these areas, asymptomatic infections are common but considered benign and so, are not treated. The effects of such infections on seizures in patients with epilepsy is unknown. This study examined the relationship between P. falciparum infection and seizure control in children with a unique epilepsy type, the nodding syndrome. DESIGN: This cross-sectional study was nested in an ongoing trial 'Doxycycline for the treatment of nodding syndrome (NCT02850913)'...
October 18, 2018: BMJ Open
https://www.readbyqxmd.com/read/30341083/whole-proteome-profiling-of-n-myristoyltransferase-activity-and-inhibition-using-sortase-a
#11
Andrea Goya Grocin, Remigiusz A Serwa, Julia Morales Sanfrutos, Markus Ritzefeld, Edward W Tate
N -myristoylation is the covalent addition of a 14-carbon saturated fatty acid (myristate) to the N-terminal glycine of specific protein substrates by N -myristoyltransferase (NMT) and plays an important role in protein regulation by controlling localization, stability, and interactions. We developed a novel method for whole-proteome profiling of free N-terminal glycines through labeling with S. Aureus sortase A (SrtA) and used it for assessment of target engagement by an NMT inhibitor. Analysis of the SrtA-labeling pattern with an engineered biotinylated depsipeptide SrtA substrate (Biotin-ALPET-Haa, Haa = 2-hydroxyacetamide) enabled whole proteome identification and quantification of de novo generated N-terminal Gly proteins in response to NMT inhibition by nanoLC-MS/MS proteomics, and was confirmed for specific substrates across multiple cell lines by gel-based analyses and ELISA...
October 19, 2018: Molecular & Cellular Proteomics: MCP
https://www.readbyqxmd.com/read/30340927/early-injection-laryngoplasty-after-surgery-30-cases-and-proposed-aspiration-assessment-protocol
#12
Sara Abu-Ghanem, Shannon Rudy, Sandra Deane, Shu Wei Tsai, Liang-Chun Shih, Edward J Damrose, Chih-Kwang Sung
Vocal fold movement impairment may significantly compromise postoperative recovery and quality of life of patients following thoracic or cardiothoracic surgery or prolonged intubation. The literature is limited and there is no standard screening protocol for the optimal postoperative swallowing and aspiration evaluations. We performed retrospective review of adult patients undergoing early vocal fold (VF) injection laryngoplasty for acute postoperative Vocal fold movement impairment (<30 days) that had both pre- and postinjection speech language pathologist (SLP) performed swallowing/aspiration evaluations...
October 16, 2018: Journal of Voice: Official Journal of the Voice Foundation
https://www.readbyqxmd.com/read/30340632/talk-cpr-a-technology-project-to-improve-communication-in-do-not-attempt-cardiopulmonary-resuscitation-decisions-in-palliative-illness
#13
Mark Taubert, James Norris, Sioned Edwards, Veronica Snow, Ilora Gillian Finlay
BACKGROUND: A national Do Not Attempt Cardiopulmonary Resuscitation policy was rolled out for the National Health Service in Wales in 2015. A national steering group led on producing information videos and a website for patients, carers and healthcare professionals, forming part of a quality improvement program. Videos were planned, scripted and produced with healthcare professionals and patient/carer representatives, and were completed with both English and Welsh language versions. The TalkCPR videos encourage and promote open discussion about Cardiopulmonary Resuscitation (CPR) and DNACPR in palliative care situations...
October 19, 2018: BMC Palliative Care
https://www.readbyqxmd.com/read/30340197/the-influence-of-residential-and-workday-population-mobility-on-exposure-to-air-pollution-in-the-uk
#14
Stefan Reis, Tomáš Liška, Massimo Vieno, Edward J Carnell, Rachel Beck, Tom Clemens, Ulrike Dragosits, Samuel J Tomlinson, David Leaver, Mathew R Heal
Traditional approaches of quantifying population-level exposure to air pollution assume that concentrations of air pollutants at the residential address of the study population are representative for overall exposure. This introduces potential bias in the quantification of human health effects. Our study combines new UK Census data comprising information on workday population densities, with high spatio-temporal resolution air pollution concentration fields from the WRF-EMEP4UK atmospheric chemistry transport model, to derive more realistic estimates of population exposure to NO2 , PM2...
October 15, 2018: Environment International
https://www.readbyqxmd.com/read/30340182/effects-of-post-exposure-naps-on-exposure-therapy-for-social-anxiety
#15
Edward F Pace-Schott, Ryan M Bottary, Se-Yun Kim, Peter L Rosencrans, Shilpa Vijayakumar, Scott P Orr, Natasha B Lasko, Elizabeth M Goetter, Amanda W Baker, Matt T Bianchi, Karen Gannon, Susanne S Hoeppner, Stefan G Hofmann, Naomi M Simon
Exposure therapy for social anxiety disorder (SAD) utilizes fear extinction, a memory process enhanced by sleep. We investigated whether naps following exposure sessions might improve symptoms and biomarkers in response to social stress in adults undergoing 5-week exposure-based group SAD therapy. Thirty-two participants aged 18-39 (18 females) with SAD were randomized. Before and after treatment, participants completed the Liebowitz Social Anxiety Scale (LSAS) and underwent a Trier Social Stress Test with psychophysiological monitoring (mpTSST) that included skin conductance (SCL), electromyographic (EMG) and electrocardiographic recording, and an auditory startle procedure while anticipating the social stressor...
October 9, 2018: Psychiatry Research
https://www.readbyqxmd.com/read/30339977/male-sexual-enhancers-from-the-peruvian-amazon
#16
Guillermo Schmeda-Hirschmann, Alberto Burgos-Edwards, Cristina Theoduloz, Felipe Jiménez-Aspee, Gabriel Vargas-Arana
ETHNOPHARMACOLOGICAL RELEVANCE: Selected Peruvian Amazon plants are macerated into sugar cane distillates to prepare alcoholic beverages used to improve male sexual performance. The tree bark from Campsiandra angustifolia Spruce ex Benth (Fabaceae), Swartzia polyphylla DC (Fabaceae), Minquartia guianensis Aubl. (Olacaceae) and Thynantus panurensis (Bureau) Sandwith (Bignoniaceae) usually are used as crude drugs in mixtures of several ingredients. AIM OF STUDY: Describe the chemical composition of the most traded traditional male enhancer beverages, namely "Levántate Lazaro" and "Siete veces sin sacarla", and their single crude drug constituents, as well as their inhibitory activity towards the enzyme phosphodiesterase-5...
October 16, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/30339769/triplet-therapies-the-new-standard-of-care-for-multiple-myeloma-how-to-manage-common-toxicities
#17
Agne Paner, Tochukwu M Okwuosa, Kristin J Richardson, Edward N Libby
Multiple three drug combination regimens have been approved for the treatment of multiple myeloma in the last few years. Triplets have become the new standard of care for transplant eligible and ineligible patients with newly diagnosed as well as relapsed multiple myeloma. Novel agents have a unique profile of side effects. The management of toxicities is important to maintain quality of life and maximize treatment duration and benefit. Areas covered: This article reviews efficacy data, incidence of key adverse events and provide recommendations and expert opinion regarding how to manage common toxicities in triplet therapies...
October 19, 2018: Expert Review of Hematology
https://www.readbyqxmd.com/read/30339747/chlorination-of-source-water-containing-iodinated-x-ray-contrast-media-mutagenicity-and-identification-of-new-iodinated-disinfection-by-products
#18
Cristina Postigo, David M DeMarini, Mikayla D Armstrong, Hannah K Liberatore, Karsten Lamann, Susana Y Kimura, Amy A Cuthbertson, Sarah H Warren, Susan D Richardson, Tony McDonald, Yusupha M Sey, Nana Osei B Ackerson, Stephen Edward Duirk, Jane Ellen Simmons
Iodinated contrast media (ICM) are non-mutagenic agents administered for X-ray imaging of soft tissues. ICM can reach µg/L levels in surface waters because they are administered at high doses, excreted largely un-metabolized, and poorly removed by wastewater treatment. Iodinated disinfection by-products (I-DBPs) are highly genotoxic and have been reported in disinfected waters containing ICM. We assessed the mutagenicity in Salmonella of extracts of chlorinated source water containing one of four ICM (iopamidol, iopromide, iohexol, and diatrizoate)...
October 19, 2018: Environmental Science & Technology
https://www.readbyqxmd.com/read/30339727/harnessing-autophagy-to-overcome-mek-inhibitor-induced-resistance-in-metastatic-melanoma
#19
S Verykiou, M Alexander, N Edwards, R Plummer, B Chaudhry, P E Lovat, D S Hill
BACKGROUND: Patients with malignant melanoma often relapse following treatment with BRAF and/or MEK inhibitors (MEKi) due to development of drug resistance by melanoma subpopulations, mediated through induction of generic survival mechanisms. OBJECTIVES: The aim of this study was to establish the temporal pattern of CD271 regulation (a stem cell marker that mediates tumour aggressiveness) during development of resistance by melanoma to the MEKi trametinib, and to determine the association between development of resistance to trametinib and induction of pro-survival autophagy...
October 19, 2018: British Journal of Dermatology
https://www.readbyqxmd.com/read/30339569/a-12-day-old-male-with-a-skin-tag-on-the-chin-challenge
#20
Syed M Abedi, Freya Van Driessche, Jaime Alexander, Edward Heilman, Sharon Glick
No abstract text is available yet for this article.
November 2018: American Journal of Dermatopathology
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