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N T Q Alves, R M Ximenes, R J B Jorge, J A M Silveira, J V A Santos, F A P Rodrigues, P H S Costa, F A F Xavier, J S A M Evangelista, A Havt, V C G Soares, M H Toyama, A N A Oliveira, R M Araújo, R S Alves, H S A Monteiro
Bredemeyera floribunda roots are popularly used to treat snakebites in the semiarid region of Northeast Brazil, and previous studies indicate the anti-ophidian actions of triterpenoid saponins found in its roots. To assess B. floribunda root extract (BFRE) activity against the effects of Bothrops jararacussu venom (BjuV), antiphospholipasic, antiproteolytic, antihemorrhagic, antinecrotic, and anti-edematogenic activities were investigated in mice. Phytochemical analysis revealed the presence of saponins, flavonoids, and sugars, with rutin and saccharose being the major constituents of BFRE...
December 3, 2018: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
Fatma Sultan Kilic, Bilgin Kaygisiz, Sule Aydin, Cafer Yildirim, Hadi Karimkhani, Setenay Oner
Objective: Pregabalin (PGB) is a compound used in the treatment of epilepsy, anxiety, and neuropathic pain. Experimental data also indicate that PGB can reduce inflammatory pain. We aimed to investigate the anti-inflammatory effects of PGB on carrageenan (CAR)-induced paw edema and its effects on tumor necrosis factor-α (TNF-α) and interleukine-1β (IL-1β) acting as acute phase cytokines in inflammation, and anti-inflammatory cytokine IL-10, in rats. Materials and Methods: Single doses of PGB 30, 50, and 100 mg/kg and indomethacin (INDO) 5 mg/kg in the treatment groups and saline in the control group were injected once intraperitoneally prior to administration of 100 μl of 1% CAR into the right hind paw of the rats...
October 2018: Eurasian Journal of Medicine
Saniya Virani, Zhongxing Liang, Younghyoun Yoon, Hyunsuk Shim, Suazette R Mooring
CXCR4 and its cognate ligand CXCL12 has been linked to various pathways such as cancer metastasis, inflammation, HIV-1 proliferation, and auto-immune diseases. Small molecules have shown potential as CXCR4 inhibitors and modulators, and therefore can mitigate diseases related to the CXCR4-CXCL12 pathway. We have designed and synthesized a series of 2,5-diamino and 2,5-dianilinomethyl pyridine derivatives as potential CXCR4 antagonists. Thirteen compounds have an effective concentration (EC) of 100 nM or less in a binding affinity assay and nine of these have at least 75% inhibition of invasion in Matrigel binding assay...
November 27, 2018: Bioorganic & Medicinal Chemistry Letters
Li-Li Gong, Song Yang, He Liu, Wen Zhang, Lu-Lu Ren, Fei-Fei Han, Ya-Li Lv, Zi-Rui Wan, Li-Hong Liu
Akebia saponin D, which is originates from Dipsacus asper Wall, has been used as a tonic, an analgesic and anti-inflammatory agent for the therapy of low back pain, rheumatic arthritis, traumatic hematoma, habitual abortion and bone fractures in traditional Chinese medicine. However, the anti-nociceptive and anti-inflammatory activity and mechanism of Akebia saponin D has been rarely reported. The aim of this study was to investigate the anti-nociceptive and anti-inflammatory activity of Akebia saponin D and to assess its possible mechanism...
November 30, 2018: European Journal of Pharmacology
Simona Pergolizzi, Valeria D'Angelo, Marialuisa Aragona, Paola Dugo, Francesco Cacciola, Gioele Capillo, Giacomo Dugo, Eugenia Rita Lauriano
Since a long time caffeine has been used in pharmaceutical and cosmetic preparations due to its favorable effects on the skin. The aim of this study was to evaluate the topical anti-inflammatory activity (carrageenan-induced paw oedema) of an ointment prepared using a methanolic extract from green beans of C. robusta via histology. Results showed that the treatment with the ointment reduced the paw oedema within 3 and 5 h post-carrageenan administration. The immunohistochemical evaluations of αSMA, Langerin and S100 gave further support to the morphological analysis...
December 3, 2018: Natural Product Research
Dragana Srebro, Sonja Vučković, Aleksandar Milovanović, Katarina Savić Vujović, Milica Prostran
Background: Inflammatory pain is the most commonly treated clinical pain, since it develops following trauma or surgery, and accompanies rheumatic or arthritic diseases. Tramadol is one of the most frequently used opioid analgesics in acute and chronic pain of different origin. Magnesium is a widely used dietary supplement that was recently shown to be a safe analgesic drug in different models of inflammatory pain. Aim: This study aimed to evaluate the effects of systemically or locally injected tramadol with/without systemically injected magnesium sulfate in prophylactic or therapeutic protocols of application in a rat model of somatic inflammation...
2018: Frontiers in Pharmacology
Zhaoyan Yu, Wei Xu, Haibo Wang
The aim of the present study was to investigate the effect of resveratrol on acute pharyngitis in the mice models induced by xylene and carrageenan treatment. The mice treated with various doses of resveratrol (5, 10, 15, 20 and 30 mg/kg) showed inhibition of edema in a dose dependent manner. The edema formation was reduced by 67% in the mice treated with 20 mg/kg of resveratrol compared to those in the control group. A significant (P < 0.02) reduction of paw swelling was observed in the mice treated with 20 mg/kg dose of resveratrol compared to the control group...
November 2018: Saudi Journal of Biological Sciences
A L Ellis, T B Mills, I T Norton, A B Norton-Welch
HYPOTHESIS: Polysaccharides such as kappa carrageenan are often utilised in fat replacement techniques in the food industry. However, the structural role they can provide within a product is limited by their hydrophilic nature. Hydrophilic particles can be surface-activated by hydrophobic modification e.g. in-situ interaction with a surfactant. This can drastically improve foam stability by providing a structural barrier around bubble interfaces offering protection against disproportionation and coalescence...
November 24, 2018: Journal of Colloid and Interface Science
Ali Pourjavadi, Mohadeseh Doroudian, Amirkhashayar Ahadpour, Shahram Azari
Scaffolds for tissue engineering of specific sites such as cardiac, nerve, and bone tissues need a comprehensive design of three dimensional materials that covers all aspects of chemical composition and physical structures, required for regeneration of desired cells. Hydrogels, possessing highly hydrated and interconnected structures, are promising materials for tissue engineering applications. Improvement of an injectable hydrogel from biocompatible polysaccharides and poly‑N‑isopropyl acryl amide enriched with Au nanoparticles are the main goal of this study...
November 28, 2018: International Journal of Biological Macromolecules
Alana de Freitas Pires, Mirna Marques Bezerra, Renata Morais Ferreira Amorim, Francisco Lucas Faustino do Nascimento, Marcia Machado Marinho, Raniere Mata Moura, Mayara Torquato Lima Silva, Jorge Luís Almeida Correia, Benildo Sousa Cavada, Ana Maria S Assreuy, Kyria Santiago Nascimento
Lonchocarpus campestris (tribe Dalbergieae) possess a mannose biding lectin (LCaL) purified by ion exchange chromatography on DEAE-Sephacel, HiTrap DEAE FF and TSKgel engaged in AKTA-HPLC system. LCaL agglutinates trypsinized rabbit erythrocytes and its activity was maintained after incubation in a wide range of temperature (4-100 °C) and pH (4-9). The lectin had its apparent molecular weight evaluated by size-exclusion chromatography and SDS-PAGE and presented a profile of 10 kDa and 25 kDa in denaturing and native conditions, respectively...
November 27, 2018: International Journal of Biological Macromolecules
Louis P Sandjo, Stephane Zingue, Marcus V P Dos Santos Nascimento, Milene H de Moraes, Geison Vicente, Solomon K S Amoah, Eduardo M Dalmarco, Tania S Frode, Tânia B Creczynski-Pasa, Mario Steindel
BACKGROUND: Curry powder is a blend of spices that is extensively consumed worldwide and mainly in Central Asia. Its preparation is strictly related to each locality and because of the health benefits of its constituents, eight commercial forms of this condiment were biologically and chemically investigated. This study aimed to compare their chemical profile as well as their anti-inflammatory, cytotoxic, and antiparasitic activities. RESULTS: Cur 1 and 7 inhibited leukocyte influx and myeloperoxidase activity, while only 7 was active on protein exudate and NOx species...
November 26, 2018: Journal of the Science of Food and Agriculture
Jacenir V Da Silva, Rafael C Dos Santos, Pedro C O Júnior, Milena M C Pederiva, Candida A L Kassuya, Claudia A L Cardoso, Zefa V Pereira, Ana L T G Ruiz, Mary Ann Foglio, Joao E De Carvalho, Anelise S N Formagio
The aim of this research was to investigate the anti-inflammatory, antiproliferative and antioxidant activities of the leaves (MEL-TS) and bark (MEB-TS) from T. silvatica. We evaluated the concentrations of phenolic compounds, condensed tannins, flavonoids, flavonols and HPLC/PDA analysis. MEL-TS and MEB-TS were analysed by LC-PDA, and the results revealed the presence of caffeic acid in both extracts. It showed high total phenolics concentrations (270.8 ± 17.10 mg GAE/ g extract and 278.8 ± 25.13 mg GAE/g extract, respectively), and content of flavonoids in MEL-TS (209...
November 23, 2018: Current Pharmaceutical Biotechnology
Rukmanikrishnan Balasubramanian, Sam Soo Kim, Jintae Lee, Jaewoong Lee
The hydrogel based composite film was prepared from k-Carrageenan (k-C), xanthan gum (X) and gellan gum (G) by solvent casting method. The transparent films made from these gellable materials with synergistic hydrogel composition have soft texture, good elasticity and excellent break strength. The k-C/X/G based nanocomposite films prepared from different weight ratio of TiO2 nanoparticles were characterized for new packaging materials. The morphology, structure and microstructure properties of the k-C/X/G and TiO2 nanocomposite films were characterized by FT-IR, XRD and SEM analysis...
November 16, 2018: International Journal of Biological Macromolecules
Mohamed A Yassin, Abdul Aziz M Gad, Ahmed F Ghanem, Mona H Abdel Rehim
Isolation of cellulose nanofibers (CNF) using cellulase immobilized on cheap and easily formed polymeric gel disks is discussed. Such gel disks based on carrageenan gel coated with hyperbranched polyamidoamine that can covalently bind to cellulase through glutaraldehyde spacer. Thermal and mechanical stability of the coated gel disks were significantly improved. Free and immobilized cellulase exhibited maximum activities at 50 °C and pH 5. However, immobilized cellulase exhibited broader temperature stability than in the free form...
February 1, 2019: Carbohydrate Polymers
Leonardo Mendes de Souza Mesquita, Caroline Fabri Bittencourt Rodrigues, Cláudia Quintino da Rocha, Mayara Silveira Bianchim, Clenilson Martins Rodrigues, Vanda Maria de Oliveira, Henrique Hessel Gaeta, Mariana Novo Belchor, Marcos Hikari Toyama, Wagner Vilegas
We recognize the chemical composition of the acetonic extract of Rhizophora mangle barks (AERM) using mass spectrometry analysis [liquid chromatography (LC)-ESI-IT-MS/MS and matrix-assisted laser desorption/ionization-time of flight-MS (MALDI-TOF)]. Analgesic activity was evaluated by formalin and tail-flick experimental assays. Anti-inflammatory activity was performed by paw edema test induced by carrageenan and 48/80 compounds. The first series of experiments involved [LC]-FIA-IT-MS/MS with 11 separated catechins derivatives until degree of polymerization 3 (DP3)...
November 14, 2018: Natural Products and Bioprospecting
Baishuang Zeng, Jinwei Chai, Zhenhui Deng, Tiaofei Ye, Wenbin Chen, Dan Li, Xin Chen, Ming Chen, Xueqing Xu
Antimicrobial peptides (AMPs) are key components of host immune defense of vertebrates against microbial invasions. Here, we report a new AMP (esculentin-1GN) characterized from the skin of the frog Hylarana guentheri. Esculentin-1GN (GLFSKKGGKGGKSWIKGVFKGIKGIGKEVGGDVIRTGIEIAACKIKGEC) with high amphipathic α-helical structure in membrane-mimetic environments has the microbial-killing activity by destruction of the cell membrane. Moreover, esculentin-1GN inhibits LPS-induced expression of proinflammatory nitric oxide, interleukin-1β, interleukin-6, and tumor necrosis factor while it enhances expression of interleukin-10...
November 27, 2018: Journal of Medicinal Chemistry
Muhammad Afzaal, Farhan Saeed, Muhammad Umair Arshad, Muhammad Tahir Nadeem, Muhammad Saeed, Tabussam Tufail
The objective of this work was to explore the effect of two encapsulating polysaccharides (sodium alginate and carrageenan) on the viability of probiotic bacteria (L. acidophilus) in ice cream and under simulated gastrointestinal (GIT) conditions. For the purpose, probiotic cells were encapsulated in sodium alginate and carrageenan by an encapsulator using standard operating conditions. Ice cream was manufactured by adding free and microencapsulated probiotics. The survival of free and encapsulated probiotics was monitored over a period of 120 days at - 20 °C...
November 14, 2018: Probiotics and Antimicrobial Proteins
Amal Ahmed Eltobshi, Elham Abdelmonem Mohamed, Galal Mahmoud Abdelghani, Ahmed Talaat Nouh
Background: Effective treatment of osteoarthritis necessitates both symptomatic relief and hindrance of joint degeneration progression. Non-steroidal anti-inflammatory drugs permit symptomatic relief only and can cause mucosal injury in the gut. Before absorption, diacerein (Dcn) is converted into rhein that counteracts cartilage degeneration without affecting prostaglandin production. Yet, low solubility and laxative action of unabsorbed rhein in the colon hindered its use. Thus, enhanced Dcn dissolution would allow absorption at the upper gut improving its bioavailability and possibly abolishing the laxative action...
2018: International Journal of Nanomedicine
Like Mao, Qiuyue Pan, Fang Yuan, Yanxiang Gao
Soy protein isolate (SPI) and carrageenan (IC) complex coacervates were formed through electrostatic attractions for encapsulating Bifidobacterium longum. The effects of pH (2.0-5.0) and SPI:IC mass ratios (10:1, 15:1, 20:1) on coacervate yield, entrapment efficiency and viability of the probiotic bacteria were investigated. The coacervates produced at pH 3 had higher yields and entrapment efficiency, and a SPI:IC mass ratio of 10:1 produced a complex coacervate with more compact microstructure. Compared to the native ones, the bacteria encapsulated in the coacervates had significantly improved viability during storage (4 °C), pasteurization (85 °C for 5, 10 and 30 min) and in vitro dynamic gastric and intestinal digestion...
March 15, 2019: Food Chemistry
Ramanathan Yegappan, Vignesh Selvaprithiviraj, Sivashanmugam Amirthalingam, Annapoorna Mohandas, Nathaniel S Hwang, R Jayakumar
Functional biomaterials that couple angiogenesis and osteogenesis processes are vital for bone tissue engineering and bone remodeling. Herein we developed an injectable carrageenan nanocomposite hydrogel incorporated with whitlockite nanoparticles and an angiogenic drug, dimethyloxallylglycine. Synthesized whitlockite nanoparticles and nanocomposite hydrogels were characterized using SEM, TEM, EDS and FTIR. Developed hydrogels were injectable, mechanically stable, cytocompatible and has better protein adsorption...
October 26, 2018: International Journal of Biological Macromolecules
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