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Lucía Gayoso, Diana Ansorena, Iciar Astiasarán
BACKGROUND: Bioaccessibility of bioactive compounds for functional food deserves to be evaluated. An in vitro gastrointestinal digestion model was applied to provide information about the extent of lipid hydrolysis, oxidative stability and bioaccessibility of algae oil (42% of docosahexaenoic acid - DHA), comparing three lipid delivery systems: bulk oil, soy protein stabilized O/W emulsion and carrageenan gelled emulsion. RESULTS: Lipid digestion kinetics was slightly influenced by the delivery systems...
October 16, 2018: Journal of the Science of Food and Agriculture
Malavika Srikanth, Wee Siong Chew, Tatsuma Hind, Siew Mon Lim, Nicholas Wei Jie Hay, Jasmine Hui Min Lee, Rich Rivera, Jerold Chun, Wei-Yi Ong, Deron R Herr
Lysophosphatidic acid receptor 1 (LPA1 ) is one of six G protein-coupled receptors (GPCRs) activated by the bioactive lipid, lysophosphatidic acid (LPA). Previous studies have shown that LPA1 signaling plays a major role in the pathophysiology of neuropathic pain. It has also been shown that the inhibition of phospholipase A2 , an enzyme upstream of LPA synthesis, reduces mechanical allodynia in experimental inflammatory orofacial pain. This suggests that the LPA-LPA1 axis may mediate inflammatory pain in addition to its known role in neuropathic pain, but this activity has not been reported...
October 12, 2018: European Journal of Pharmacology
Seul Ah Lee, Bo-Ram Park, Sung-Min Moon, Seul Hee Han, Chun Sung Kim
This study evaluated the anti-inflammatory potential of a 40% prethanol extract of Trifolium pratense leaves (40% PeTP) using in vitro (RAW264.7 cells) and in vivo (carrageenan-induced inflammation model) experiments. Pretreatment with 40% PeTP significantly inhibited the LPS-induced expression of nitric oxide (NO), prostaglandin E2 (PGE2 ), inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), and inflammatory cytokines, including tumour necrosis factor (TNF)-α, interleukin (IL)-1β, and IL-6 in RAW264...
October 15, 2018: Archives of Physiology and Biochemistry
Ali Abbas, Syed Saeed-Ul Hassan, Ali Sharif, Shoaib Ahmed
The whole plant, Tricholepis chaetolepis, powder was investigated using proximate and fluorescence analysis along with determining the extractive values. Total phenolics, flavonoids and total protein contents of n-hexane, chloroform and methanolic extracts of the whole plant were also determined. The anti-diabetic activity of all the three extracts of the plant was determined by in vitro alpha-amylase inhibition assay. The anti-oxidant potential was evaluated using Phosophomolybdenum and DPPH methods. The anti-inflammatory potential of all extracts were determined by carrageenan-induced rat paw oedema model...
October 15, 2018: Natural Product Research
Ana Carla A Souza, Fabíula F Abreu, Lúcio R L Diniz, Renata Grespan, Josimari M DeSantana, Lucindo J Quintans-Júnior, Paula P Menezes, Adriano A S Araújo, Cristiane B Correa, Simone A Teixeira, Marcelo N Muscará, Soraia K P Costa, Enilton A Camargo
BACKGROUND: Skeletal muscle inflammation is strongly associated with pain and may impair regeneration and functional recovery after injury. Since anti-inflammatory and antinociceptive effects have been described for the inclusion complex of carvacrol and β-cyclodextrin (βCD-carvacrol), this study investigated the effects of βCD-carvacrol in a model of acute skeletal muscle inflammation. METHODS: Muscle injury was induced in male Wistar rats by injection of 3% carrageenan in the gastrocnemius muscle...
October 11, 2018: Pharmacological Reports: PR
M Milard, F Laugerette, S Bugeat, P Plaisancié, M Létisse, E Meugnier, E Loizon, A Durand, C Buisson, A Géloën, S Serieye, M-C Michalski
Additives stabilize or improve the organoleptic or functional properties (or both) of many dairy products including whipping cream. Their influence on the metabolic effect of dairy cream is scarcely known. We tested the hypothesis that added emulsifier (lactic acid esters of mono- and diglycerides; MAG/DAG), thickener (carrageenan, CGN), or both, could modify the metabolic effect, notably in the intestine and liver. Nine-week-old male C57Bl/6J mice were fed UHT cream (indirect treatment) mixed with nonlipidic powder (final: 13% milkfat) for 1 or 4 wk...
October 10, 2018: Journal of Dairy Science
M Milard, F Laugerette, S Bugeat, P Plaisancié, M Létisse, E Meugnier, E Loizon, A Durand, C Buisson, A Géloën, S Serieye, M-C Michalski
Although UHT heat treatment is being optimized to improve the stability and functional properties of dairy products, its metabolic effects remain scarcely known. As such, we studied the effect of the type of UHT process on lipid metabolism, intestinal barrier, and inflammation in mice. Nine-week-old male C57Bl/6J mice were fed a diet composed of nonlipidic powder mixed with different UHT dairy creams (final: 13% milkfat) for 1 or 4 wk. All creams contained 0.02% of thickener (carrageenan) and were treated via either (1) classical indirect heating process (Th), (2) indirect process at higher temperature (Th+), or (3) direct process by steam injection (ThD)...
October 10, 2018: Journal of Dairy Science
Letícia Vieira, Aline Aparecida Saldanha, Andreza Marinho Moraes, Flávio Martins de Oliveira, Débora Oliveira Lopes, Leandro Augusto de Oliveira Barbosa, Rosy Iara Maciel de Azambuja Ribeiro, Ralph Gruppi Thomé, Hélio Batista Dos Santos, José Augusto Ferreira Perez Villar, Adriana Cristina Soares
Recent findings have demonstrated new therapeutic functions of cardiotonic steroids, a process that is termed drug repositioning. Despite the confirmed anti-inflammatory effects of cardiotonic steroids, their clinical use has been discouraged due to toxicity related to inhibition of the Na+ /K+ ATPase. A novel synthetic compound derived from digoxin, 21‑benzylidene digoxin (21‑BD), does not inhibit this enzyme. Herein, we evaluated the anti-inflammatory and antinociceptive effects and acute toxicity of 21‑BD...
October 10, 2018: International Immunopharmacology
Smirna Farias, Joshua S Boateng
The impact of demographic ageing is likely to be of major significance in the coming decades due to low birth rates and higher life expectancy. Older people generally require more prescribed medicines due to the presence of multiple conditions such as dysphagia which can make swallowing medicines challenging. This study involves the development, characterization and optimization of composite wafers for potential oral and buccal delivery of low dose aspirin to prevent thrombosis in elderly patients with dysphagia...
October 9, 2018: International Journal of Pharmaceutics
A N Coelho-de-Souza, C F Dos-Santos, L N Lopes-Filho, F R Holanda, A C Oliveira, Y A Gomes-Vasconcelos, K A Oliveira, F W Ferreira-da-Silva, K S Silva-Alves, J H Leal-Cardoso
Essential oils (EO) are volatile liquids responsible for the aroma of plants. Pterodon polygalaeflorus seeds have received widespread use in folk medicine for the treatment of inflammatory diseases. For this reason and because Pterodon polygalaeflorus seeds have great EO content, which is frequently pharmacologically active, the present study aimed to evaluate the antinociceptive effect of EO from Pterodon polygalaeflorus (EOPPgfl) and its acute toxic effects. The EEOPPgfl sample, which was extracted by steam distillation of the seeds, had a yield of 2...
October 4, 2018: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
Harshavardhan V Pawar, John Tetteh, Philip Debrah, Joshua S Boateng
Infected chronic wounds heal slowly, exhibiting prolonged inflammation, biofilm formation, bacterial resistance, high exudate and ineffectiveness of systemic antimicrobials. Composite dressings (films and wafers) comprising polyox/carrageenan (POL-CAR) and polyox/sodium alginate (POL-SA), loaded with diclofenac (DLF) and streptomycin (STP) were formulated and tested for antibacterial activity against 2 × 105  CFU/mL of Escherichia coli, Pseudomonas aeruginosa and Staphylococcus aureus representing infected chronic wounds and compared with marketed silver dressings...
October 6, 2018: International Journal of Biological Macromolecules
Yi Deng, Min Huang, Dan Sun, Yi Hou, Yubao Li, Taosheng Dong, Xiaohong Wang, Li Zhang, Weizhong Yang
Chemically linked Double network (DN) hydrogels display extraordinary mechanical attributes but mostly suffer from poor self-healing property and unsatisfactory biocompatibility due to the irreversible breaks in their chemical-linked networks and the use of toxic chemical crosslinking agents. To address these limitations, we developed a novel κ-carrageenan/polyacrylamide (KC/PAM) DN hydrogel through a dual physical-crosslinking strategy, with the ductile, hydrophobically associated PAM being the first network, and the rigid potassium ion (K+) cross-linked KC being the second network...
October 8, 2018: ACS Applied Materials & Interfaces
Ana Daura Travassos de Oliveira Moraes, Mirelly Dianne Santos de Miranda, Íris Trindade Tenório Jacob, Cézar Augusto da Cruz Amorim, Ricardo Olímpio de Moura, Simone Ângela Soares da Silva, Milena Botelho Pereira Soares, Sinara Mônica Vitalino de Almeida, Túlio Ricardo Couto de Lima Souza, Jamerson Ferreira de Oliveira, Teresinha Gonçalves da Silva, Cristiane Moutinho Lagos de Melo, Diogo Rodrigo Magalhães Moreira, Maria do Carmo Alves de Lima
The objective of this work was to obtain and evaluate anti-inflammatory in vitro, in vivo and in silico potential of novel indole-N-acylhydrazone derivatives. In total, 10 new compounds (3a-j) were synthesized in satisfactory yields, through a condensation reaction in a single synthesis step. In the lymphoproliferation assay, using mice splenocytes, 3a and 3b showed inhibition of lymphocyte proliferation of 62.7% (±3.5) and 50.7% (±2), respectively, while dexamethasone presented an inhibition of 74.6% (±2...
July 17, 2018: Bioorganic & Medicinal Chemistry
Jelena Katanić, Eva-Maria Pferschy-Wenzig, Vladimir Mihailović, Tatjana Boroja, San-Po Pan, Stefanie Nikles, Nadine Kretschmer, Gvozden Rosić, Dragica Selaković, Jovana Joksimović, Rudolf Bauer
Filipendula vulgaris Moench (dropwort) is used in traditional medicine for relieving various inflammation-related diseases. In the present study, the phytochemical profile of F. vulgaris aerial part (FVA) and root (FVR) methanolic extracts was evaluated by LC-DAD-HRMS analysis. Furthermore, their in vitro and in vivo anti-inflammatory effects, as well as their potential cytotoxicity, were assessed. Results showed that the extracts mainly contain phenolics like flavonoids, hydrolyzable tannins, procyanidins, and phenolic acid derivatives, including gaultherin...
October 3, 2018: Food and Chemical Toxicology
Tae-Kyung Kim, Jae-Yun Shim, Ko-Eun Hwang, Young-Boong Kim, Jung-Min Sung, Hyun-Dong Paik, Yun-Sang Choi
We investigated the quality of duck ham restructured with various hydrocolloids (Alginic acid, Konjac, Carrageenan) on proximate composition, cooking loss, emulsion stability, pH, color, texture profile analysis (TPA), protein solubility, sensory characteristics, and apparent viscosity. Restructured duck ham was prepared as follows: control with no hydrocolloids, T1 (Alginate 1%), T2 (Alginate 0.5% + Konjac 0.5%), T3 (Alginate 0.7% + Konjac 0.3%), T4 (Alginate 0.5% + Carrageenan 0.5%), and T5 (Alginate 0.7% + Carrageenan 0...
October 5, 2018: Poultry Science
Yanli Wang, Chao Yuan, Bo Cui, Yawei Liu
The influences of 4 mono- and di-valent cations (K+ , Na+ , Mg2+ and Ca2+ ) on the mechanical, sol-gel transition and freeze-thaw properties of κ-carrageenan gel were investigated. Texture profile analysis results demonstrated that the texture behavior of gelatinized κ-carrageenan was obviously influenced by the cation types and concentrations and the influence of K+ was the greatest. The gelling temperature (Tg ) of κ-carrageenan gel showed a positive correlation with cation concentrations and the influence of K+ was still the largest...
December 15, 2018: Carbohydrate Polymers
Himanshu Sharma, Viney Lather, Ajmer Singh Grewal, Deepti Pandita
BACKGROUND: Phosphodiesterase 4 (PDE4) and phosphodiesterase 7 (PDE7), members of PDE superfamily, catalyse hydrolysis of cyclic adenosine monophosphate in pro-inflammatory and immunomodulatory cells leading to increased inflammatory processes. Dual inhibitors of PDE4 and PDE7 are a novel class of drug candidates which can regulate pro-inflammatory as well as immune T-cell function and can be particularly useful in the treatment of a wide variety of immune and inflammatory disorders with less undesirable adverse effects...
October 3, 2018: Current Computer-aided Drug Design
Kawther El-Shafei, Fouad Mahmoud Fouad Elshaghabee, Hoda Samir El-Sayed, Jihan Mohamed Kassem
BACKGROUND: Our study was conducted in two stages; the first stage was to examine the fructose fermentation profile by Lactobacillus (Lb.) casei FEGY9973. The second stage was to investigate the viability properties of Lb. casei either during cold storage of labneh or under simulated gastrointestinal tract (GIT) conditions. METHODS: Labneh as a carrier medium was classified into four treatments; the first one con- tained 2% free cells of Lb. casei as a control. The second, third and fourth treatments used 2% of encapsulated cells of Lb...
July 2018: Acta Scientiarum Polonorum. Technologia Alimentaria
Ekaterina R Gasilova, Galina P Aleksandrova, Elena N Vlasova, Vadim A Baigildin
κ-carrageenan is a linear sulfated anionic gelling polysaccharide obtained from red seaweed algae by an alkaline hydrolysis. We applied static and dynamic light scattering (DLS), capillary viscometry, FT-IR, and electrophoretic DLS to gain insight into the effect of deep alkaline hydrolysis (95 °C, pH = 10 during Th = 60, 75, and 90 min) on κ-carrageenan macromolecules in a coil conformation. As DLS of coil-like κ-carrageenans is usually complicated by spurious permanent aggregates, the alkaline hydrolysis of κ-carrageenans has not been studied by DLS...
September 30, 2018: Biopolymers
Reza Farahmandfar, Maryam Asnaashari, Afsaneh Taheri, Tandis Khosravi Rad
The effects of sage (Salvia macrosiphon) seed gum (SSG), balangu (Lallemantia royleana) seed gum (BSG) and carrageenan gum were examined on the foaming qualities (foam stability, foam capacity and overrun), viscoelastic properties (frequency sweep test and extrusion test) and flow properties of thickened cream as a function of gum concentration. The flow behavior of the cream samples was fitted to the Herschel-Bulkley model (R2  > 0.95). All samples demonstrated a gel structure with higher G' (storage modulus) values than the G″ (loss modulus) values...
September 26, 2018: International Journal of Biological Macromolecules
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