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https://www.readbyqxmd.com/read/30539852/evaluation-of-the-effect-of-hesperidin-on-vascular-endothelial-growth-factor-gene-expression-in-rat-skin-animal-models-following-cobalt-60-gamma-irradiation
#1
Gholamhassan Haddadi, Akbar Abbaszadeh, Mohammad Amin Mosleh-Shirazi, Mohammad Ali Okhovat, Ashkan Salajeghe, Zhila Ghorbani
Introduction: Skin is highly prone to radiation damage. Radiation burn is defined as damage to the skin or other biological tissues induced by radiofrequency or ionizing radiation. Vascular endothelial growth factor (VEGF) is a heparin-binded pro-angiogenic factor. Flavonoids belong to a family of polyphenol chemical compounds that are frequently present in fruits and vegetables. Hesperidin is an agent belonging to the flavonoid family. The aim of this study is to investigate whether hesperidin can affect the VEGF gene expression in rat skin following gamma irradiation or not...
December 2018: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/30537490/novel-trends-in-application-of-stem-cells-in-skin-wound-healing
#2
REVIEW
Marek Kucharzewski, Ewa Rojczyk, Katarzyna Wilemska-Kucharzewska, Renata Wilk, Jacek Hudecki, Marek J Los
The latest findings indicate the huge therapeutic potential of stem cells in regenerative medicine, including the healing of chronic wounds. Main stem cell types involved in wound healing process are: epidermal and dermal stem cells, mesenchymal stem cells (MSCs), endothelial progenitor cells (EPCs) and hematopoietic stem cells (HSCs). In the therapy of chronic wounds, they can be administrated either topically or using different matrix like hydrogels, scaffolds, dermal substitutes and extracellular matrix (ECM) derivatives...
December 8, 2018: European Journal of Pharmacology
https://www.readbyqxmd.com/read/30537049/complications-after-discharge-and-delays-in-adjuvant-chemotherapy-following-colonic-resection-a-cohort-study-of-linked-primary-and-secondary-care-data
#3
Chanpreet S Arhi, Elaine M Burns, George Bouras, Paul Aylin, Paul Ziprin, Ara Darzi
AIM: By understanding the reasons for delays in adjuvant chemotherapy (AC) after colonic resection, there is the potential to improve patient outcome. The aim of this study is to determine the extent and impact of complications post hospital discharge on AC delays. METHOD: The study cohort included patients who had a colorectal cancer resection in HES, with linkage to primary care data provided by CPRD. Complications during the index hospital stay (from HES) and post discharge (from CPRD) were compared...
December 10, 2018: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
https://www.readbyqxmd.com/read/30531754/-evaluation-of-local-treatment-of-donor-sites-wounds-in-patients-with-deep-burns
#4
A E Mordyakov, A L Charyshkin
AIM: To assess the impact of local treatment of donor sites wounds in patients with deep burns on the frequency of complications and to identify the main risk factors of complications of donor sites wounds. MATERIAL AND METHODS: There were 486 patients with deep burns who underwent split-thickness skin grafting. Treatment of donor sites wounds was carried by using of moisture-controlled dressings DDB-M in the main group (n=56). Conventional approach including once imposed wet-to-dry gauze bandages was applied in the control group...
2018: Khirurgiia
https://www.readbyqxmd.com/read/30529119/comparative-study-of-conventional-and-topical-heparin-treatment-in-second-degree-burn-patients-for-burn-analgesia-and-wound-healing
#5
Sobia Manzoor, Farid Ahmad Khan, Sohail Muhammad, Rehan Qayyum, Imran Muhammad, Umer Nazir, Muhammad Mustehsan Bashir
OBJECTIVE: To compare clinical outcome of topical conventional with topical heparin treatment in 2nd degree or partial thickness (PTB) burn patients. METHODS: Patients, between the ages of 14 and 60 years with 2nd degree burns involving <20%. Total body surface area (TBSA) on front of chest, abdomen and upper limbs excluding hands and lower limbs were enrolled from September 2015 to August 2016. Patients were randomized to conventional or heparin treatment groups...
December 7, 2018: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/30527709/wound-healing-after-cultured-epithelial-autografting-in-patients-with-massive-burn-injury-a-cohort-study
#6
Cheng Hean Lo, Shiva Akbarzadeh, Catriona McLean, Andrew Ives, Eldho Paul, Wendy A Brown, Heather Cleland
BACKGROUND/AIM: Last century, our laboratory produced Cultured Epithelial Autograft (CEA) for clinical use by the affiliated adult burn service and other burn units across the country. Production of CEA for clinical use was discontinued after several years because of a low success rate and subsequent low demand. Recently, at our burns unit, a cell culture program was reintroduced as a direct response to the need for improvement in ongoing deficiencies and clinical requirements in burn wound closure...
November 13, 2018: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
https://www.readbyqxmd.com/read/30527475/ultrasonography-superior-over-visual-assessment-in-evaluation-of-wound-healing-after-dermabrasion
#7
Yuehou Zhang, Ran Zhao, Yongqian Cao, Min Zhang, Chengyu Zang, Siyuan Yin, Yibing Wang
BACKGROUND: Dermabrasion as one kind of treatment for partial thickness wounds is controversial. Visual assessment as the main way to evaluate the healing process of burn wounds is also inaccurate. In this study we try to explore whether dermabrasion accelerates healing in wounds of partial thickness and determine a reliable way to evaluate epithelialization. MATERIALS AND METHODS: Eight female Bama minipigs were anesthetized, and eighteen partial thickness wounds (circle, 4...
February 2019: Journal of Surgical Research
https://www.readbyqxmd.com/read/30527451/the-impact-of-skin-allograft-on-inpatient-outcomes-in-the-treatment-of-major-burns-20-50-total-body-surface-area-a-propensity-score-matched-analysis-using-the-nationwide-inpatient-sample
#8
Clifford C Sheckter, Alexander Li, Brian Pridgen, Amber W Trickey, Yvonne Karanas, Catherine Curtin
BACKGROUND: Human cadaveric skin (allograft) is used in treating major burns both as temporizing wound coverage and a means of testing wound bed viability following burn excision. There is limited information on outcomes, and clinicians disagree on indications for application in intermediate-sized burns. This study aims to improve understanding of allograft use in 20-50% total body surface burns by assessing current utilization and evaluating inpatient outcomes. METHODS: Discharge data from the Nationwide Inpatient Sample (NIS), Healthcare Cost and Utilization Project (HCUP), Agency for Healthcare Research and Quality assessed 3557 major burn patients (>second degree depth and 20-50% TBSA) undergoing operative treatment...
December 4, 2018: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/30517046/novel-pharmacotherapy-for-burn-wounds-what-are-the-advancements
#9
Michael R Hamblin
The prognosis for severe burns has improved significantly over the past 50 years. Meanwhile, burns have become an affliction mainly affecting the less well-developed regions of the world. Early excision and skin grafting has led to major improvements in therapeutic outcomes. Areas covered: The purpose of this article is to survey the use of pharmacotherapy to treat different pathophysiological complications of burn injury. The author, herein, discusses the use of drug treatments for a number of systemic metabolic disturbances including hyperglycemia, elevated catabolism, and gluconeogenesis...
December 5, 2018: Expert Opinion on Pharmacotherapy
https://www.readbyqxmd.com/read/30516481/improvement-of-the-dermatension-method-in-the-reconstructive-recovery-surgery-of-defects-of-soft-tissues-of-various-etiology
#10
R Abdullaiev, G Oleynik, V Kremen, A Gryazin, E Timchenko
The problem of treating patients with loss of the skin and with a complicated course of the wound process remains topical. The problem is that, despite the relative technical simplicity of the dermatension method, the most significant complication is the decubitus of the stretchable flap, which is associated with a relatively high incidence of acute blood circulatory disturbances in the stretch tissues due to vascular compression with an excessive amount of injected fluid. The aim of the work is to improve the method of dermatension in reconstructive and recovery surgery of soft tissue defects of various genesis by planning and implementing dermatension at all its steps with instrumental control of the process using ultrasound and ICT in a complex...
October 2018: Georgian Medical News
https://www.readbyqxmd.com/read/30515810/adipose-derived-stem-cells-for-wound-healing
#11
REVIEW
Alireza Hassanshahi, Mohammadhossein Hassanshahi, Samira Khabbazi, Zahra Hosseini-Khah, Yaser Peymanfar, Saman Qhalamkari, Yu-Wen Su, Cory J Xian
Wound healing is a complex but a fine-tuned biological process in which human skin has the ability to regenerate itself following damage. However, in particular conditions such as deep burn or diabetes the process of wound healing is compromised. Despite investigations on the potency of a wide variety of stem cells for wound healing, adipose-derived stem cells (ASCs) seem to possess the least limitations for clinical applications, and literature showed that ASCs can improve the process of wound healing very likely by promoting angiogenesis and/or vascularisation, modulating immune response, and inducing epithelialization in the wound...
December 4, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/30515348/application-of-animated-cartoons-in-reducing-the-pain-of-dressing-changes-in-children-with-burn-injuries
#12
Zhicai Feng, Qiyu Tang, Junqing Lin, Quanyong He, Cheng Peng
BACKGROUND: Nonpharmacological management remains one of the central pain interventional therapies in the burn unit. VR and other distraction treatments for adults have achieved great advantages in pain relief. METHODS: A within-subject study was conducted to evaluate 54 participants aged from 3 to 7. In the control group, a standard analgesic, ibuprofen, was used over the period of dressing change, whereas animated cartoons were played simultaneously in the intervention-group condition...
2018: International Journal of Burns and Trauma
https://www.readbyqxmd.com/read/30513388/the-role-of-telemedicine-in-the-management-of-maxillofacial-trauma-in-emergency-departments-preliminary-results
#13
B Ambroise, H Benateau, R Garmi, K Hauchard, R Prevost, A Veyssière
New technologies have over the past forty years become widespread across all domains of basic and applied research particularly in health-related fields. Telemedicine is a form of remote medical practice using information and communication technologies. It connects one or more health professionals with other health professionals or with patients. Within the framework of emergencies in maxillofacial surgery, requests received for specialist advice often pertain to procedures to be followed for facial wounds, bites, burns, maxillofacial bone trauma or facial cellulitis...
December 1, 2018: Journal of Stomatology, Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/30510648/adjuvant-effect-of-oral-silymarin-on-patients-wound-healing-process-caused-by-thermal-injuries
#14
Mohsen Mahmoodi-Nesheli, Shaabanali Alizadeh, Hassan Solhi, Jila Mohseni, Masomeh Mahmoodi-Nesheli
Background: According to the side effects of the usual treatment of burns, in improving the patients' prognosis, there is a need to introduce faster and more effective adjuvant therapies to treat wounds, thus to improve the prognosis of patients. The aim of this study was to investigate the effect of adjuvant treatment with oral silymarin on wound healing process caused by second degree-burns among the patients admitted to Valiasr Hospital of Arak. Methods: This randomized, double-blind clinical trial study was carried out on 80 patients with second-degree burns covering 20 to 30 percent of the body with flame...
2018: Caspian Journal of Internal Medicine
https://www.readbyqxmd.com/read/30510412/enhancement-of-wound-healing-by-single-wall-multi-wall-carbon-nanotubes-complexed-with-chitosan
#15
Naim Kittana, Mohyeddin Assali, Hanood Abu-Rass, Susanne Lutz, Rama Hindawi, Lina Ghannam, Marah Zakarneh, Ahmad Mousa
Background: Impaired wound healing is commonly associated with many health problems, including diabetes, bedsores and extensive burns. In such cases, healing often takes a long time, which subjects patients to various complications. This study aims to investigate whether single-wall or multi-wall carbon nanotubes complexed with chitosan hydrogel can improve wound healing. Materials and methods: Initially, the effects of the complexes on the viability and functionality of fibroblasts were investigated in engineered connective tissues...
2018: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/30509765/uptake-of-phmb-in-a-bacterial-nanocellulose-based-wound-dressing-a-feasible-clinical-procedure
#16
Ives Bernardelli de Mattos, Judith C J Holzer, Alexandru-Cristian Tuca, Florian Groeber-Becker, Martin Funk, Daniel Popp, Selma Mautner, Thomas Birngruber, Lars-Peter Kamolz
BACKGROUND: With the increase of antimicrobial resistance in recent decades, other methods of preventing and fighting infections must be considered. Burn patients, whose wound areas are often extensive, are especially prone to wound infections. The loading of bacterial nanocellulose (BNC) with antiseptics has already been successfully performed but unfortunately, the described procedure is time-consuming and thus not applicable in a clinical emergency setting. Therefore, a clinically feasible approach was established...
November 30, 2018: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/30508922/combination-of-meshed-dermis-graft-and-cultured-epithelial-autograft-for-massive-burns-three-case-reports
#17
Minoru Hayashi, Kotaro Yoshitake, Ryohei Tokunaka, Yuki Yoshida, Mikiko Oshima, Sayo Tatsuta, Taishi Hamada, Ayako Kamitomo, Akito Hamajima
RATIONALE: This study reviewed the use of a combination of meshed dermis graft and cultured epithelial autografts (CEA) made in Japan "JACE" (JACE; Japan Tissue Engineering Co., Ltd. Japan) for the treatment of massively burns. JACE is a Green-type CEA. We recently described a method in which we prepare the wound bed for burned patients by using artificial dermis and graft with JACE on a meshed 6:1 split-thickness autograft. In this report, we used a meshed 3:1 split-thickness dermis graft without epithelial cells...
November 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/30507548/titanium-dioxide-nanoparticle-gelatin-a-potential-burn-wound-healing-biomaterial
#18
Sara Javanmardi, Amaneh Ghojoghi, Baharak Divband, Javad Ashrafi
INTRODUCTION: Over the past few decades, the application of nanotechnology has gained progressive interest for the regeneration of injured and burned tissues. OBJECTIVE: This study evaluates the effects of titanium dioxide (TiO₂) nanoparticle (NP)/gelatin on burn wound healing in mice. MATERIALS AND METHODS: Sixty healthy male BALB/c mice with a full-thickness burn wound were randomized into 4 experimental groups of 15 animals each: (1) control group was treated with normal saline; (2) gelatin group was treated with gelatin-based ointment; (3) silver sulfadiazine group was treated with silver sulfadiazine 1% ointment; and (4) TiO₂ NP/gelatin group (TNG) received TiO₂ NP/gelatin...
December 2018: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/30506370/salmon-fibrinogen-and-chitosan-scaffold-for-tissue-engineering-in-vitro-and-in-vivo-evaluation
#19
Ivo Laidmäe, Kaspars Ērglis, Andrejs Cēbers, Paul A Janmey, Raivo Uibo
3D fibrous scaffolds have received much recent attention in regenerative medicine. Use of fibrous scaffolds has shown promising results in tissue engineering and wound healing. Here we report the development and properties of a novel fibrous scaffold that is useful for promoting wound healing. A scaffold made of salmon fibrinogen and chitosan is produced by electrospinning, resulting in a biocompatible material mimicking the structure of the native extracellular matrix (ECM) with suitable biochemical and mechanical properties...
November 30, 2018: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/30503413/synthesis-and-characterization-of-pyridoxine-nicotine-and-nicotinamide-salts-of-dithiophosphoric-acids-as-antibacterial-agents-against-resistant-wound-infection
#20
Trinh Dang, Ilyas S Nizamov, Ramazan Z Salikhov, Leysan R Sabirzyanova, Vyacheslav V Vorobev, Tatyana I Burganova, Marina M Shaidoullina, Elvira S Batyeva, Rafael A Cherkasov, Timur I Abdullin
The pyridine-derived biomolecules are of considerable interest in developing medicinal compounds with various specific activities. Novel ammonium salts of pyridoxine, (S)-(-)-nicotine and nicotinamide with O,O-diorganyl dithiophosphoric acids (DTPA) were synthesized and characterized. The complexation of chiral monoterpenyl DTPA, including (S)-(-)-menthyl, (R)-(+)-menthyl, (1R)-endo-(+)-fenchyl, (1S,2S,3S,5R)-(+)-isopinocampheolyl derivatives, with pyridoxine and nicotine provided effective antibacterial compounds 3a,b,e,f, and 5a,b,d,f with MIC values against Gram-positive bacteria as low as 10 µM (6 µg/mL)...
November 13, 2018: Bioorganic & Medicinal Chemistry
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