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https://www.readbyqxmd.com/read/30121925/evaluation-of-regenerative-potential-of-cryopreserved-adenosine-modified-monocytes-on-the-model-of-burn-wounds
#1
K V Nevskaya, V V Ivanov, E S Mainagasheva, S S Gutor, S P Lezhava, A E Sazonov
We studied viability of adenosine-modified monocytes after cryopreservation and their regenerative potential. The optimal method of cell cryopreservation was the use of serum-free medium followed by storage in liquid nitrogen. Injections of adenosine-modified monocytes after 12-week cryopreservation around grade IIIB burn wound accelerated healing of the skin defect and significantly improved the histological pattern of the damage area at delayed terms.
August 18, 2018: Bulletin of Experimental Biology and Medicine
https://www.readbyqxmd.com/read/30120654/pirfenidone-ointment-modulates-the-burn-wound-bed-in-c57bl-6-mice-by-suppressing-inflammatory-responses
#2
Jorge L Medina, Eliza A Sebastian, Andrea B Fourcaudot, Rossella Dorati, Kai P Leung
An inflammatory response is the normal response to a burn-induced injury. The burn-associated inflammation can lead to further tissue damage as the tissue tries to repair the damage. Prolonged or excessive inflammation is associated with increased fibrosis of burn wounds and the development of hypertrophic scars. The high incidence of hypertrophic scar formation is one of the many challenges to treating deep partial-thickness burns. Prophylactic treatment to improve burn-induced hypertrophic scarring is lacking...
August 17, 2018: Inflammation
https://www.readbyqxmd.com/read/30118166/therapeutic-efficacy-of-early-photobiomodulation-therapy-on-the-zones-of-stasis-in-burns-an-experimental-rat-model-study
#3
Jian Jin, Xingfeng Zheng, Fang He, Yongcun Zhang, Hao Zhou, Pengfei Luo, Xiaoyan Hu, Zhaofan Xia
This study aimed to investigate the role of photobiomodulation therapy in preventing zones of stasis in burn wounds. We hypothesized that photobiomodulation therapy could promote tissue formation and release of nitric oxide (NO) through a photochemical reaction, and reduce local inflammatory responses, thereby dilating local microvessels, reducing necrosis and apoptosis. Thirty rats were randomly divided into control (CG) and laser groups (LG) (15 per group). The zone of stasis was formed by applying a hot brass comb to the skin resulting in 4 rectangular burns separated by 3 unburned interspaces...
August 17, 2018: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/30116226/applications-of-bacteriophages-in-the-treatment-of-localized-infections-in-humans
#4
REVIEW
Vera V Morozova, Valentin V Vlassov, Nina V Tikunova
In the recent years, multidrug-resistant bacteria have become a global threat, and phage therapy may to be used as an alternative to antibiotics or, at least, as a supplementary approach to treatment of some bacterial infections. Here, we describe the results of bacteriophage application in clinical practice for the treatment of localized infections in wounds, burns, and trophic ulcers, including diabetic foot ulcers. This mini-review includes data from various studies available in English, as well as serial case reports published in Russian scientific literature (with, at least, abstracts accessible in English)...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/30115530/pirfenidone-increases-the-epithelialization-rate-of-skin-graft-donor-sites
#5
Gabriel Ángel Mecott-Rivera, Jorge Alejandro Aguilar-Baqueiro, Stephano Bracho, Ivette Miranda-Maldonado, Rodolfo Franco-Márquez, Yanko Castro-Govea, Edgar Gerardo Dorsey-Treviño, Mauricio Manuel García-Pérez
BACKGROUND: Improving epithelialization of donor sites of split-thickness skin grafts (STSG) is extremely important in burned patients. We aimed to assess the efficacy of pirfenidone, a drug with anti-inflammatory, antifibrotic, and antioxidant effects, to accelerate wound healing. We hypothesized that pirfenidone accelerates the epithelialization rates in donor sites. METHODS: We included 28 patients requiring STSGs with donor sites of at least 7.5×10cm. After harvesting, the donor sites were randomly treated with either non-adherent gauze or topical pirfenidone and covered with non-adherent gauze...
August 13, 2018: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/30111204/therapeutic-intervention-of-aloe-gel-containing-nano-sized-and-micron-sized-silver-sulfadiazine-gel-on-second-degree-burn-a-comparative-study
#6
Md Abul Barkat, Harshita, Faheem Hyder Pottoo, Satya Prakash Singh, Farhan J Ahmad
The current work focuses on the formulation development, optimization, and in vivo assessment of nano-sized silver sulfadiazine ( nSSD) and micron-sized silver sulfadiazine ( mSSD) topical gel composed of Aloe vera gel ( Aloe gel) and Carbopol 940 for the management of second-degree burn wound. The optimized concentration of gel-forming agent (Carbopol 940) was chosen based on best possible consistency and spreadability of the gel. The second-degree burn infliction was developed in the posterior region of rats followed by anesthesia...
August 16, 2018: International Journal of Lower Extremity Wounds
https://www.readbyqxmd.com/read/30108574/chestnut-honey-and-bacteriophage-application-to-control-pseudomonas-aeruginosa-and-escherichia-coli-biofilms-evaluation-in-an-ex-vivo-wound-model
#7
Ana Oliveira, Jéssica C Sousa, Ana C Silva, Luís D R Melo, Sanna Sillankorva
Chronic skin wounds represent a major burn both economically and socially. Pseudomonas aeruginosa and Escherichia coli are among the most common colonizers of infected wounds and are prolific biofilm formers. Biofilms are a major problem in infections due to their increasingly difficult control and eradication, and tolerance to multiple prescribed drugs. As so, alternative methods are necessary. Bacteriophages (phages) and honey are both seen as a promising approach for biofilm related infections. Phages have specificity toward a bacterial genus, species or even strain, self-replicating nature, and avoid dysbiosis...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/30107518/multiregional-utilization-of-a-mobile-device-app-for-triage-and-transfer-of-burn-patients
#8
Arek J Wiktor, Laura Madsen, Heather Carmichael, Tyler Smith, Shana Zanyk, Hamed Amani, Anne Lambert Wagner
Technology and telehealth have the potential to optimize burn care in areas limited by lack of expertise and geographic distance from a Burn Center. This study reports a multicenter, multiregional experience using a mobile phone app to facilitate triage of patients by allowing referring providers to send encrypted photos, thus enhancing the telephone consultation process. A retrospective review was conducted on referrals from August 2016 to July 2017 at three regional Burn Centers that utilize the same mobile phone app...
August 10, 2018: Journal of Burn Care & Research: Official Publication of the American Burn Association
https://www.readbyqxmd.com/read/30105667/using-paracrine-effects-of-ad-mscs-on-keratinocyte-cultivation-and-fabrication-of-epidermal-sheets-for-improving-clinical-applications
#9
Halimeh Hassanzadeh, Maryam M Matin, Hojjat Naderi-Meshkin, Hamid Reza Bidkhori, Mahdi Mirahmadi, Mahmood Raeesolmohaddeseen, Nasser Sanjar-Moussavi, Ahmad Reza Bahrami
Recent advances in wound healing have made cell therapy a potential approach for the treatment of various types of skin defects such as trauma, burns, scars and diabetic leg ulcers. Cultured keratinocytes have been applied to burn patients since 1981. Patients with acute and chronic wounds can be treated with autologous/allograft cultured keratinocytes. There are various methods for cultivation of epidermal keratinocytes used in cell therapy. One of the important properties of an efficient cell therapy is the preservation of epidermal stem cells...
August 13, 2018: Cell and Tissue Banking
https://www.readbyqxmd.com/read/30100172/antifungal-and-antibacterial-activity-of-densely-dispersed-silver-nanospheres-with-homogeneity-size-which-synthesized-using-chicory-an-in-vitro-study
#10
M Khatami, N Zafarnia, M Heydarpoor Bami, I Sharifi, H Singh
With increase in isolation of multi and extensive drug resistance hospital pathogens (MDR, XDR) in burn centers of many hospitals in the world, attempt to use nanomaterials for treatment of burn-infected patients is the focus of researches all around the world. In the present investigation silver nanospheres (Ag NSs) has been synthesized by chicory seed exudates (CSE). The various parameters influencing the mechanism of Ag NSs synthesis including temperature, concentration, pH and time were studied. Greener Ag NSs were formed when the reaction conditions were altered with respect to pH, concentration of AgNO3 and incubation temperature...
August 9, 2018: Journal de Mycologie Médicale
https://www.readbyqxmd.com/read/30098195/differential-distribution-of-laminin-n-terminus-%C3%AE-31-across-the-ocular-surface-implications-for-corneal-wound-repair
#11
Valentina Barrera, Lee D Troughton, Valentina Iorio, Siyin Liu, Olutobi Oyewole, Carl M Sheridan, Kevin J Hamill
Purpose: Laminin N-terminus (LaNt) α31 is a relatively unstudied protein derived from the laminin α3 gene but structurally similar to netrins. LaNt α31 has, to date, been investigated only in two-dimensional (2D) keratinocyte culture where it influences cell migration and adhesion, processes integral to wound repair. Here we investigated LaNt α31 distribution in ocular surface epithelium, during limbal stem cell activation, and corneal wound healing. Methods: Human, mouse, and pig eyes, ex vivo limbal explant cultures, and alkali burn wounds were processed for immunohistochemistry with antibodies against LaNt α31 along with progenitor cell-associated proteins...
August 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/30095423/poly-%C3%A9-caprolactone-chitosan-poly-vinyl-alcohol-nanofibrous-scaffolds-for-skin-excisional-and-burn-wounds-in-a-canine-model
#12
Adeleh Gholipour-Kanani, Monireh Mohsenzadegan, Mohammadreza Fayyazi, Hajir Bahrami, Ali Samadikuchaksaraei
Poly (ɛ-caprolactone)-chitosan-poly (vinyl alcohol) (PCL: Cs: PVA) nanofibrous blend scaffolds were known as useful materials for skin wound healing and would help the healing process about 50% faster at the final time point. From the previous studies by the authors, PCL: Cs: PVA (in 2: 1: 1.5 mass ratio) nanofibres showed high efficacy in healing on rat models. In this study, the scaffolds were examined in burn and excision wounds healing on dogs as bigger models. The scaffolds were applied on dorsum skin wounds ( n  = 5) then macroscopic and microscopic investigations were carried out to measure the wounds areas and to track healing rate, respectively...
August 2018: IET Nanobiotechnology
https://www.readbyqxmd.com/read/30092820/adipose-tissue-derived-extracellular-fraction-characterization-biological-and-clinical-considerations-in-regenerative-medicine
#13
Barbara Bellei, Emilia Migliano, Marinella Tedesco, Silvia Caputo, Federica Papaccio, Gianluca Lopez, Mauro Picardo
BACKGROUND: Adipose tissue-derived stem cells are considered to be a promising source in the field of cell therapy and regenerative medicine. In addition to direct cell replacement using adipose tissue or purified stem cells, intercellular molecule exchange by the adipose tissue complex, a vast array of bioactive secretory factors, demonstrated beneficial effects by reducing tissue damage and stimulation of endogenous repair. However, for therapeutic purposes, the use of secretome derivatives, such as full conditioned media or purified exosomes generated in vitro, may present considerable disadvantages for cell manufacturing, storage, product safety, and their potential as a ready-to-go therapeutic product...
August 9, 2018: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/30086993/effects-of-topical-application-of-platelet-rich-plasma-on-esophageal-stricture-and-oxidative-stress-after-caustic-burn-in-rats-is-autologous-treatment-possible
#14
Mustafa Onur Oztan, Fatma Demet Arslan, Sule Oztan, Gulden Diniz, Gokhan Koyluoglu
BACKGROUND: Caustic esophageal burn is still an important health problem in pediatric surgery. Although there are a number of experimental and clinical studies to increase the recovery of the esophagus and reduce the stenosis rate, there is no consensus on the treatment protocol. Platelet-rich plasma (PRP) is an autologous blood product, which has positive effects on wound healing, reepithelization and scar prevention. The aim of our study was to investigate the effects of PRP on stricture formation and oxidative status after caustic esophageal injury in rats...
August 1, 2018: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/30083512/invasive-fungal-infection-with-absidia-corymbifera-in-immunocompetent-patient-with-electrical-scalp-burn
#15
Prashant Moon, N Jithendran
Invasive fungal infection in burn injury is caused by inoculation of fungal spore from patient skin, respiratory tract or from care giver. The risk factors for acquiring fungal infection in burns include age of burns, total burn size, full thickness burns, inhalational injury, prolonged hospital stay, late surgical excision, open dressing, central venous catheters, antibiotics, steroid treatment, long-term artificial ventilation, fungal wound colonization, hyperglycemic episodes and other immunosuppressive disorders...
May 2018: World Journal of Plastic Surgery
https://www.readbyqxmd.com/read/30083507/plaster-burn-challenge-to-plastic-surgeon
#16
Varun Singh Chauhan, Mohd Altaf Mir
BACKGROUND: The thermal burn is accidental and also is the hidden and worst complication of medical plaster application. This study evaluated clinical and aetiological profile and severity of plaster burns. METHODS: In Department of Burns, Plastic and Reconstructive Surgery from 1st August 2014 to 31st December 2015, six patients with plaster burn were assessed for total body surface area and depth of burn. The wounds were cultured and dressed with moist dressings daily till the surgical procedure and satisfactory healing...
May 2018: World Journal of Plastic Surgery
https://www.readbyqxmd.com/read/30081003/tweak-fn14-signals-mediate-burn-wound-repair
#17
Jing Liu, Yale Liu, Lingling Peng, Juxue Li, Kunyi Wu, Linlin Xia, Jiawen Wu, Sijia Wang, Xuening Wang, Qilu Liu, Weihui Zeng, Yumin Xia
Tumor necrosis factor-like weak inducer of apoptosis (TWEAK) acts by engaging with fibroblast growth factor-inducible 14 (Fn14) to regulate inflammatory responses, fibrosis, and tissue remodeling, which are central in the repair processes of wounds. This study aims to explore the potential role of the TWEAK/Fn14 pathway in the healing of cutaneous burn wounds. Third-degree burns were introduced in the wild-type and Fn14-deficient BALB/c mice, followed by evaluation of wound areas and histological changes. The downstream cytokines including growth factors were also examined in lesional skin...
August 3, 2018: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/30078473/the-concurrent-use-of-probiotic-microorganism-and-collagen-hydrogel-scaffold-enhances-burn-wound-healing-an-in-vivo-evaluation
#18
Ahmad Oryan, Maryam Jalili, Amir Kamali, Behrooz Nikahval
Treatment of burn wounds is technically demanding and several attempts have been taken to improve wound healing. Silver sulfadiazine antibiotic has been shown to have some beneficial effects on wound healing via reduction in infection. This study was designed to investigate the impact of collagen hydrogel-scaffold dressing with or without topical use of Saccharomyces cerevisiae on cutaneous burn wound healing in rat. Four circular 1cm cutaneous wounds were created in the dorsum back of rats, 48h post-burning...
August 2, 2018: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/30072198/the-lived-experience-and-quality-of-life-with-burn-scarring-the-results-from-a-large-scale-online-survey
#19
M P Brewin, S J Homer
A large-scale online survey was designed to both inform and direct the development of an online community healthcare hub for people living with scarring. Focussed areas of questioning were generated to gather information on psychological symptoms, scar support and knowledge of wounds and healing. Simple statistical data was produced on the severity, aetiology and location of scarring. A secondary data analysis of the survey responses was conducted on more focussed themes. This survey was completed by 1034 people living with scars, 119 of which had burn scarring...
July 30, 2018: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/30066700/enhanced-healing-activity-of-burn-wound-infection-by-a-dextran-ha-hydrogel-enriched-with-sanguinarine
#20
Qiyu Zhu, Ming Jiang, Qiang Liu, Shina Yan, Longbao Feng, Yong Lan, Guiqiu Shan, Wei Xue, Rui Guo
Burn wounds are associated with a series of risks, such as infection and pathologic scar tissue formation, which significantly delay wound healing and lead to complications. In this study, we successfully fabricated a dextran-hyaluronic acid (Dex-HA) hydrogel enriched with sanguinarine (SA) incorporated into gelatin microspheres (GMs), which had high porosity, good swelling ratio, enhanced NIH-3T3 fibroblast cell proliferation, and sustained SA release profile. The in vitro degradation results indicate that the SA/GMs/Dex-HA hydrogel can be degraded...
August 1, 2018: Biomaterials Science
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