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https://www.readbyqxmd.com/read/30334637/immunophenotype-involved-in-igg4-related-disease
#1
Satoshi Kubo, Shingo Nakayamada, Yoshiya Tanaka
As stated in the comprehensive diagnostic criteria for IgG4-related disease (IgG4-RD), IgG4-RD is characterized by elevated serum IgG4 level and pathological findings, characterized by infiltration of IgG4-positive plasma cells. In addition to fibrotic changes, dysregulated activation of lymphocytes is considered as one of major pathogenic events in IgG4-RD. Among lymphocytes, the importance of plasmablast, T follicular helper (Tfh) cells, T type 2 helper (Th2) cells, T regulatory (Treg) cells, and CD4 positive T cells with cytotoxic activity has been reported...
October 18, 2018: Modern Rheumatology
https://www.readbyqxmd.com/read/30334477/cytokines-produced-by-innate-immune-cells-in-igg4-related-disease
#2
Tomoe Yoshikawa, Tomohiro Watanabe, Kosuke Minaga, Ken Kamata, Masatoshi Kudo
IgG4-related disease (IgG4-RD) is a newly defined multi-organ disease proposed by Japanese physicians. IgG4-RD is characterized by elevated serum levels of IgG4 and massive infiltration of IgG4-expressing plasma cells in the affected organs. Recent studies have shown that abnormal adaptive immune responses mediated by T helper type 2 cells, regulatory T cells, follicular helper T cells, cytotoxic CD4+ T cells, and plasmablasts are involved in IgG4-RD immunopathogenesis. In addition to adaptive immune responses, innate immune responses play pathogenic roles in IgG4-RD...
October 18, 2018: Modern Rheumatology
https://www.readbyqxmd.com/read/30334372/extended-immunophenotyping-reference-values-in-a-healthy-pediatric-population
#3
Marina Garcia-Prat, Daniel Álvarez-Sierra, Aina Aguiló-Cucurull, Sandra Salgado-Perandrés, Sara Briongos-Sebastian, Clara Franco-Jarava, Andrea Martin-Nalda, Roger Colobran, Isabel Montserrat, Manuel Hernández-González, Ricardo Pujol-Borrell, Pere Soler-Palacin, Mónica Martínez-Gallo
BACKGROUND: For the accurate diagnosis of immunodeficiencies is crucial to compare patients' immunology laboratory values with age-sex matched controls, yet there is a paucity of normal values for most populations. OBJECTIVES: To define appropriate reference values of extended lymphocyte subpopulations and T-cell receptor excision circle (TRECs) levels in healthy pediatric donors between 1 month and 18 years of age. METHODS: Extended immunophenotyping values were obtained by analysis of multiparameter flow cytometry panels for the following subpopulations: CD4+ and CD8+ Naive, Effector, Effector Memory and Central Memory, T helper subpopulations and their degrees of activation, T Regulatory cells, Recent Thymic Emigrants (RTE), B Lymphocyte subpopulations (Transitional, Naive, Preswitch-Memory, Switch-Memory, Plasmablasts, CD21low, and Exhausted), and subpopulations for Monocytes, NK cells and Dendritic Cells...
October 17, 2018: Cytometry. Part B, Clinical Cytometry
https://www.readbyqxmd.com/read/30333237/mixed-effects-association-of-single-cells-identifies-an-expanded-effector-cd4-t-cell-subset-in-rheumatoid-arthritis
#4
Chamith Y Fonseka, Deepak A Rao, Nikola C Teslovich, Ilya Korsunsky, Susan K Hannes, Kamil Slowikowski, Michael F Gurish, Laura T Donlin, James A Lederer, Michael E Weinblatt, Elena M Massarotti, Jonathan S Coblyn, Simon M Helfgott, Derrick J Todd, Vivian P Bykerk, Elizabeth W Karlson, Joerg Ermann, Yvonne C Lee, Michael B Brenner, Soumya Raychaudhuri
High-dimensional single-cell analyses have improved the ability to resolve complex mixtures of cells from human disease samples; however, identifying disease-associated cell types or cell states in patient samples remains challenging because of technical and interindividual variation. Here, we present mixed-effects modeling of associations of single cells (MASC), a reverse single-cell association strategy for testing whether case-control status influences the membership of single cells in any of multiple cellular subsets while accounting for technical confounders and biological variation...
October 17, 2018: Science Translational Medicine
https://www.readbyqxmd.com/read/30328797/interleukin-23-a-new-atherosclerosis-target
#5
Wenjing Liu, Chao Chang, Haiying Hu, Hua Yang
Accumulating evidence has shown that atherosclerosis is an inflammatory disease. The pathogenesis of atherosclerosis has been confirmed to involve an imbalance in anti-inflammatory/proinflammatory processes. Interleukin-23 (IL-23) is a heterodimeric cytokine composed of the IL-23p19 and IL-12p40 subunits of the IL-12 family. Experiments show that IL-23 induces CD4+ T cells to differentiate into T helper type 17 cells, promotes the expression of interferon-γ, and inhibits the production of Foxp3. Therefore, IL-23 induces and exacerbates effector T lymphocyte/regulatory T cell imbalance...
October 2018: Journal of Interferon & Cytokine Research
https://www.readbyqxmd.com/read/30327657/naringenin-modifies-the-development-of-lineage-specific-effector-cd4-t-cells
#6
Junpeng Wang, Xinli Niu, Chunfang Wu, Dayong Wu
Disrupted balance in the lineages of CD4+ T cell subsets, including pro-inflammatory T helper (Th) cells and anti-inflammatory regulatory T cells (Treg), is a primary pathogenic factor for developing autoimmunity. We have found that this immunomodulatory effect of naringenin on effector T cells and T-cell mediated experimental autoimmune encephalomyelitis (EAE). We therefore explored the effects of naringenin on the development of different effector CD4+ T cells. Naïve CD4+ T cells were differentiated under respective Th1, Th2, Th17, and Treg polarizing conditions with naringenin...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/30326322/pathophysiologic-mechanisms-of-chronic-rhinosinusitis-and-their-roles-in-emerging-disease-endotypes
#7
REVIEW
Ping-Ping Cao, Zhi-Chao Wang, Robert P Schleimer, Zheng Liu
OBJECTIVE: Chronic rhinosinusitis (CRS) is a heterogeneous disorder with distinct pathophysiologic mechanisms. Based on the transcription factor expression and cytokine production patterns in different types of innate lymphoid cells (ILCs), in parallel with those of adaptive CD4+ T helper (Th) cells and CD8+ cytotoxic T (Tc) cells, new perspectives on endotypes of patients are emerging around the immune response deviation into type 1 (orchestrated by ILC1s, Tc1 and Th1 cells), type 2 (characterized by ILC2s, Tc2 and Th2 cells), and type 3 (mediated by ILC3s, Tc17 and Th17 cells) responses...
October 13, 2018: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/30322965/differentiation-of-langerhans-cells-from-monocytes-and-their-specific-function-in-inducing-il-22-specific-th-cells
#8
Yohei Otsuka, Eri Watanabe, Eiji Shinya, Sadayuki Okura, Hidehisa Saeki, Teunis B H Geijtenbeek, Hidemi Takahashi
Human mucosal tissues and skin contain two distinct types of dendritic cell (DC) subsets, epidermal Langerhans cells (LCs) and dermal DCs, which can be distinguished by the expression of C-type lectin receptors, Langerin and DC-SIGN, respectively. Although peripheral blood monocytes differentiate into these distinct subsets, monocyte-derived LCs (moLCs) induced by coculture with GM-CSF, IL-4, and TGF-β1 coexpress both Langerin and DC-SIGN, suggesting that the environmental cues remain unclear. In this study, we show that LC differentiation is TGF-β1 dependent and that cofactors such as IL-4 and TNF-α promote TGF-β1-dependent LC differentiation into Langerin+ DC-SIGN- moLCs but continuous exposure to IL-4 blocks differentiation...
October 15, 2018: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/30320878/during-acute-graft-versus-host-disease-cd28-deletion-in-donor-cd8-but-not-cd4-t-cells-maintains-anti-leukemia-responses-in-mice
#9
Anna Uri, Fred Lühder, Thomas Kerkau, Niklas Beyersdorf
Donor lymphocyte infusions (DLI) together with allogeneic hematopoietic stem cell transplantation (allo-HSCT) are routinely used as second-line treatment for hematological malignancies. Mature T cells in the graft crucially mediate a Graft versus Leukemia (GvL) response, but also attack healthy tissues in the recipient leading to potentially life-threatening acute Graft versus Host Disease (aGvHD). Using inducible CD28 knock-out C57BL/6 mice as T cell donors we have now assessed whether CD28 costimulation of donor CD4+ and/ or CD8+ T cells is required for an efficient GvL effect after allogeneic T cell transplantation into BALB/c recipients...
October 15, 2018: European Journal of Immunology
https://www.readbyqxmd.com/read/30320351/cytokine-induced-alterations-of-bambi-mediate-the-reciprocal-regulation-of-human-th17-treg-cells-in-response-to-cigarette-smoke-extract
#10
Hong-Ju Liu, Gang Chen, Long Chen, Mei Zhou, Xian-Zhi Xiong, Zhao-Ji Meng, Sheng-Wen Sun, Xiao-Nan Tao
In CD4+ T helper (Th) cells, transforming growth factor β (TGF‑β) is indispensable for the induction of both regulatory T (Treg) and interleukin‑17‑producing effector T helper (Th17) cells. Although BMP and activin membrane‑bound inhibitor (BAMBI) is part of a rheostat‑like mechanism for the regulation of TGF‑β signalling and autoimmune arthritis in mouse models, the underlying activity of BAMBI on the human Th17/Treg cell axis, particularly during exposure to cigarette smoke, remains to be elucidated...
October 9, 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/30319664/lymph-node-cellular-dynamics-in-cancer-and-hiv-what-can-we-learn-for-the-follicular-cd4-tfh-cells
#11
REVIEW
Antigoni Poultsidi, Yiannis Dimopoulos, Ting-Fang He, Triantafyllos Chavakis, Emmanouil Saloustros, Peter P Lee, Constantinos Petrovas
Lymph nodes (LNs) are central in the generation of adaptive immune responses. Follicular helper CD4 T (Tfh) cells, a highly differentiated CD4 population, provide critical help for the development of antigen-specific B cell responses within the germinal center. Throughout the past decade, numerous studies have revealed the important role of Tfh cells in Human Immunodeficiency Virus (HIV) pathogenesis as well as in the development of neutralizing antibodies post-infection and post-vaccination. It has also been established that tumors influence various immune cell subsets not only in their proximity, but also in draining lymph nodes...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/30319629/determination-of-t-follicular-helper-cell-fate-by-dendritic-cells
#12
REVIEW
Jayendra Kumar Krishnaswamy, Samuel Alsén, Ulf Yrlid, Stephanie C Eisenbarth, Adam Williams
T follicular helper (Tfh) cells are a specialized subset of CD4+ T cells that collaborate with B cells to promote and regulate humoral responses. Unlike other CD4+ effector lineages, Tfh cells require interactions with both dendritic cells (DCs) and B cells to complete their differentiation. While numerous studies have assessed the potential of different DC subsets to support Tfh priming, the conclusions of these studies depend heavily on the model and method of immunization used. We propose that the location of different DC subsets within the lymph node (LN) and their access to antigen determine their potency in Tfh priming...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/30315770/alternative-splice-forms-of-cyld-mediate-ubiquitination-of-smad7-to-prevent-tgfb-signaling-and-promote-colitis
#13
Yilang Tang, Sonja Reissig, Elke Glasmacher, Tommy Regen, Florian Wanke, Alexei Nikolaev, Katharina Gerlach, Vanessa Popp, Khalad Karram, Massimo C Fantini, Jörn M Schattenberg, Peter R Galle, Markus F Neurath, Benno Weigmann, Florian C Kurschus, Nadine Hövelmeyer, Ari Waisman
BACKGROUND & AIMS: The CYLD lysine 63 deubiquitinase gene (CYLD) encodes tumor suppressor protein that is mutated in familial cylindromatosis, and variants have been associated with Crohn's disease (CD). Splice forms of CYLD that lack exons 7 and 8 regulate transcription factors and functions of immune cells. We examined expression of splice forms of CYLD in colon tissues from patients with CD and their effects in mice. METHODS: We performed immunohistochemical analyses of colon tissues from untreated patients with CD and patients without inflammatory bowel diseases (controls)...
October 10, 2018: Gastroenterology
https://www.readbyqxmd.com/read/30314911/plga-encapsulation-of-the-pseudomonas-aeruginosa-popb-vaccine-antigen-improves-th17-responses-and-confers-protection-against-experimental-acute-pneumonia
#14
Matthew M Schaefers, Biyan Duan, Boaz Mizrahi, Roger Lu, Gally Reznor, Daniel S Kohane, Gregory P Priebe
The Pseudomonas aeruginosa type III secretion system protein PopB and its chaperon protein PcrH, when co-administered with the adjuvant curdlan, elicit Th17 responses after intranasal immunization of mice. These PopB/PcrH-curdlan vaccines protect mice against acute lethal pneumonia in an IL-17-dependent fashion involving CD4 helper T cells secreting IL-17 (Th17 cells). In this study, we tested whether encapsulation of PopB/PcrH in poly-lactic-co-glycolic acid (PLGA) nanoparticles could elicit Th17 responses to PopB...
October 9, 2018: Vaccine
https://www.readbyqxmd.com/read/30314368/hydrophilic-astragalin-galactoside-induces-t-helper-type-1-mediated-immune-responses-via-dendritic-cells
#15
Jae Hyoung Jeon, Byung-Cheol Lee, Doman Kim, Daeho Cho, Tae Sung Kim
A flavonoid Astragalin (kaempferol-3- O -β-d-glucopyranoside, Ast) has several biological activities including anti-oxidant, anti-HIV, and anti-allergic effects. Nonetheless, its insolubility in hydrophilic solvents imposes restrictions on its therapeutic applications. In this study, we investigated the effects of water-soluble astragalin-galactoside (kaempferol-3- O -β-d-isomaltotrioside, Ast-Gal) on murine bone marrow-derived dendritic cell (DC) maturation and T helper (Th) cell-mediated immune responses...
October 11, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/30311182/auricular-vagus-nerve-stimulation-exerts-antiinflammatory-effects-and-immune-regulatory-function-in-a-6-ohda-model-of-parkinson-s-disease
#16
Ying Jiang, Zhentang Cao, Huizi Ma, Guihong Wang, Xuemei Wang, Zhan Wang, Yaqin Yang, Huiqing Zhao, Genliang Liu, Longling Li, Tao Feng
According to epidemiologic studies, smoking appears to downregulate the prevalence of Parkinson's disease (PD), possibly due to antiinflammatory mechanisms via activation of α7 nicotinic acetylcholine receptors (α7 nAChRs). This receptor also appears to play a role in T-cell differentiation. Recently, it has become apparent that the innate immune system participates in PD pathogenesis. The aim of this study was to evaluate the effects of auricular vagus nerve stimulation (aVNS) on substantia nigra (SN) dopaminergic neurodegeneration and the associated neuroinflammation and immune responses in a rat PD model...
October 11, 2018: Neurochemical Research
https://www.readbyqxmd.com/read/30309848/selective-loss-of-function-variants-in-il6st-cause-hyper-ige-syndrome-with-distinct-impairments-of-t-cell-phenotype-and-function
#17
Tala Shahin, Dominik Aschenbrenner, Deniz Cagdas, Sevgi Köstel Bal, Cecilia Domínguez Conde, Wojciech Garncarz, David Medgyesi, Tobias Schwerd, Betül Karaatmaca, Pınar Gur Cetinkaya, Saliha Esenboga, Stephen R F Twigg, Andrew Cant, Andrew O M Wilkie, Ilhan Tezcan, Holm H Uhlig, Kaan Boztug
Hyper-IgE Syndromes comprise a group of inborn errors of immunity. STAT3-deficient hyper-IgE syndrome is characterized by elevated serum IgE levels, recurrent infections and eczema, and characteristic skeletal anomalies. A loss-of-function biallelic mutation in IL6ST encoding the GP130 receptor subunit (p.N404Y) has very recently been identified in a singleton patient (herein referred to as PN404Y) as a novel etiology of hyper-IgE syndrome. Here, we studied a patient with hyper-IgE syndrome caused by a novel homozygous mutation in IL6ST (p...
October 11, 2018: Haematologica
https://www.readbyqxmd.com/read/30301837/the-role-of-wnt-signaling-in-mature-t-cells-t-cell-factor-is-coming-home
#18
REVIEW
Jorg van Loosdregt, Paul J Coffer
T cell factor, the effector transcription factor of the WNT signaling pathway, was so named because of the primary observation that it is indispensable for T cell development in the thymus. Since this discovery, the role of this signaling pathway has been extensively studied in T cell development, hematopoiesis, and stem cells; however, its functional role in mature T cells has remained relatively underinvestigated. Over the last few years, various studies have demonstrated that T cell factor can directly influence T cell function and the differentiation of Th1, Th2, Th17, regulatory T cell, follicular helper CD4+ T cell subsets, and CD8+ memory T cells...
October 15, 2018: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/30301533/ctla-4-regulates-t-follicular-regulatory-cell-differentiation-and-participates-in-intestinal-damage-caused-by-spontaneous-autoimmunity
#19
Gao Chao, Xiaoli Li, Yahong Ji, Ying Zhu, Na Li, Nana Zhang, Zunyong Feng, Min Niu
Cytotoxic T lymphocyte-associated protein 4 (CTLA-4) is a co-inhibitory molecule expressed by T cells and is required for immune regulation and inflammation prevention. In clinical patients, the CTLA-4 mutation causes spontaneous immune-related early-onset Crohn's disease; however, its potential mechanism is still unknown. In the current study, we found that defects in CTLA-4 in CD4 cells lead to limited differentiation of T follicular regulatory (Tfr) cells and relatively increased T follicular helper (Tfh) cells and spontaneous B cell germinal centres (GCs) responses that trigger the accumulation of autoantibodies in intestinal epithelial cells...
October 6, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/30294971/metabolic-regulation-of-innate-and-adaptive-lymphocyte-effector-responses
#20
REVIEW
Ann M Joseph, Laurel A Monticelli, Gregory F Sonnenberg
Innate and adaptive lymphocytes employ diverse effector programs that provide optimal immunity to pathogens and orchestrate tissue homeostasis, or conversely can become dysregulated to drive progression of chronic inflammatory diseases. Emerging evidence suggests that CD4+ T helper cell subsets and their innate counterparts, the innate lymphoid cell family, accomplish these complex biological roles by selectively programming their cellular metabolism in order to instruct distinct modules of lymphocyte differentiation, proliferation, and cytokine production...
November 2018: Immunological Reviews
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