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Vitiligo And Cell And Therapy

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https://www.readbyqxmd.com/read/30096104/clinical-application-of-cultured-stratified-epithelial-sheets-grown-under-feeder-or-feeder-free-conditions-for-stable-vitiligo
#1
Jian Li, Shujun Chen, Taro Uyama, Wenyu Wu, Jinhua Xu
BACKGROUND: Autologous cultured therapy has emerged as an effective treatment for stable vitiligo. However, culture methods may include harmful agents and be unsuitable for therapeutic use in humans. OBJECTIVE: To investigate the safety and efficacy of autologous cultured epithelial sheets propagated under serum-free and feeder-free conditions for the treatment of stable vitiligo. METHODS: Twenty-eight patients with stable vitiligo were included in this study...
August 9, 2018: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/30092820/adipose-tissue-derived-extracellular-fraction-characterization-biological-and-clinical-considerations-in-regenerative-medicine
#2
Barbara Bellei, Emilia Migliano, Marinella Tedesco, Silvia Caputo, Federica Papaccio, Gianluca Lopez, Mauro Picardo
BACKGROUND: Adipose tissue-derived stem cells are considered to be a promising source in the field of cell therapy and regenerative medicine. In addition to direct cell replacement using adipose tissue or purified stem cells, intercellular molecule exchange by the adipose tissue complex, a vast array of bioactive secretory factors, demonstrated beneficial effects by reducing tissue damage and stimulation of endogenous repair. However, for therapeutic purposes, the use of secretome derivatives, such as full conditioned media or purified exosomes generated in vitro, may present considerable disadvantages for cell manufacturing, storage, product safety, and their potential as a ready-to-go therapeutic product...
August 9, 2018: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/30058498/cutaneous-adverse-events-of-immune-checkpoint-inhibitors-a-summarized-overview
#3
Kerasia-Maria Plachouri, Eleftheria Vryzaki, Sophia Georgiou
BACKGROUND: The introduction of Immune Checkpoint Inhibitors in the recent years has resulted in high response rates and extended survival in patients with metastatic/advanced malignancies. Their mechanism of action is the indirect activation of cytotoxic T-cells through the blockade of inhibitory receptors of immunmodulatory pathways, such as cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4), programmed cell death protein-1 (PD-1) and its ligand (PD-L1). Despite their impressive therapeutic results, they can also induce immune-related toxicity, affecting various organs, including the skin...
July 29, 2018: Current Drug Safety
https://www.readbyqxmd.com/read/30013973/a-perspective-on-the-use-of-nb-uvb-phototherapy-vs-puva-photochemotherapy
#4
Sally H Ibbotson
Narrowband UVB (NB-UVB) phototherapy and psoralen-UVA (PUVA) photochemotherapy are widely used phototherapeutic modalities for a range of skin diseases. The main indication for NB-UVB and PUVA therapies is psoriasis, and other key diagnoses include atopic eczema, vitiligo, cutaneous T-cell lymphoma (CTCL), and the photodermatoses. The decision on choice of phototherapy is important and NB-UVB is usually the primary choice. NB-UVB phototherapy is a safe and effective therapy which is usually considered when topical agents have failed...
2018: Frontiers in Medicine
https://www.readbyqxmd.com/read/29968387/photobiomodulation-therapy-promotes-in-vitro-wound-healing-in-nicastrin-ko-hacat-cells
#5
Paola M Tricarico, Luisa Zupin, Giulia Ottaviani, Sabrina Pacor, Francette Jean-Louis, Michele Boniotto, Sergio Crovella
Mutations in NCSTN gene (encoding for nicastrin protein) are associated with hidradenitis suppurativa (HS), a chronic inflammatory disease involving hair follicles. HS is clinically handled with drugs but the most severe cases are treated with surgery. Photobiomodulation (PBM) therapy, already used in the treatment of skin diseases such as acne, herpes virus lesions, ultraviolet damage, vitiligo, hypertrophic scar, keloid, burn, psoriasis and diabetic chronic wounds, could be beneficial as an adjuvant supportive treatment to promote and foster the healing process after skin excision in HS...
July 2, 2018: Journal of Biophotonics
https://www.readbyqxmd.com/read/29799097/cutaneous-toxicities-of-new-treatments-for-melanoma
#6
REVIEW
A Boada, C Carrera, S Segura, H Collgros, P Pasquali, D Bodet, S Puig, J Malvehy
New drugs against advanced melanoma have emerged during last decade. Target therapy and immunotherapy have changed the management of patients with metastatic disease. Along with its generalized use, drug toxicities have appeared and the skin is the target organ of a significant part of them. This revision summarizes the most common side effects and consensus management to improve the compliance of therapies and patients' quality of life. Among the BRAF inhibitors, main cutaneous side effects are photosensitivity, plantar hyperkeratosis, and the appearance of verrucal keratosis or squamous cell carcinoma...
May 24, 2018: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/29575350/regulatory-t-cells-in-autoimmune-skin-diseases
#7
Hideyuki Ujiie
CD4+ Foxp3+ regulatory T cells (Tregs) are suppressors of immune activation and play a crucial role in the maintenance of peripheral tolerance. Mutations of Foxp3 result in fatal autoimmunity in multiple organs, including the skin, in both humans and mice. Many studies have demonstrated the altered frequency and functions of Tregs, changes in cytokine and chemokine levels related to Tregs and the differences in genetic background regarding Tregs in autoimmune skin disorders. Recent studies have extended our knowledge of certain properties of Tregs, especially skin-resident Tregs...
March 25, 2018: Experimental Dermatology
https://www.readbyqxmd.com/read/29512683/a-novel-psoralen-derivative-mpfc-enhances-melanogenesis-via-activation-of-p38-mapk-and-pka-signaling-pathways-in-b16-cells
#8
Li Yin, Guangxian Pang, Chao Niu, Maidina Habasi, Jun Dou, Haji Akber Aisa
As an active compound, psoralen is present in various Chinese herbal medicines and has exhibited significant activity in skin disease treatment. Its derivative 8-methoxypsoralan (8-MOP) is the most commonly used drug to induce repigmentation of vitiligo. In our previous screening assays, 4-methyl-6-phenyl-2H-furo[3,2-g]chromen-2-one (MPFC), a psoralen derivative, was identified as more effective tyrosinase and melanin activator than the positive control 8-MOP in consideration of low doses, as well as low toxicity...
June 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29468364/antitumor-in-situ-vaccination-effect-of-tnf%C3%AE-and-il-12-plasmid-dna-electrotransfer-in-a-murine-melanoma-model
#9
Urska Kamensek, Maja Cemazar, Ursa Lampreht Tratar, Katja Ursic, Gregor Sersa
Gene electrotransfer (GET) is one of the most efficient non-viral gene therapy approaches for the localized transfer of multiple genes into tumors in vivo; therefore, it is especially promising for delivering different cytokines that are toxic if administered systemically. In this study, we used concomitant intratumoral GET of two cytokines: tumor necrosis factor alpha (TNFα), a potent cytotoxic cytokine to induce in situ vaccination, and interleukin 12 (IL-12), an immunostimulatory cytokine to boost the primed local immune response into a systemic one...
May 2018: Cancer Immunology, Immunotherapy: CII
https://www.readbyqxmd.com/read/29371688/pd-l1-reverses-depigmentation-in-pmel-1-vitiligo-mice-by-increasing-the-abundance-of-tregs-in-the-skin
#10
Xiao Miao, Rong Xu, Bin Fan, Jie Chen, Xin Li, Weiwei Mao, Shengyuan Hua, Bin Li
Programmed cell death 1 ligand 1 (PD-L1) is a ligand of programmed cell death 1 (PD-1) that functions as an immune checkpoint by down-regulating immune responses. To determine whether PD-L1 is a therapy target in vitiligo treatment, Pmel-1 vitiligo mice were treated with a PD-L1 fusion protein. Treatment with this fusion protein significantly reversed/suppressed depigmentation development in adult Pmel-1 mice. Mechanistically, enrichment of regulatory T cells (Treg) in the skin was detected after PD-L1 fusion protein treatment in Pmel-1 mice...
January 25, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29318598/efficacy-and-safety-of-noncultured-melanocyte-keratinocyte-transplant-procedure-for-vitiligo-and-other-leukodermas-a-critical-analysis-of-the-evidence
#11
REVIEW
Paras P Vakharia, Dylan E Lee, Amor Khachemoune
Vitiligo is an acquired pigmentary skin of depigmentation occurring secondary to melanocyte destruction. Vitiligo and other leukodermas have a profound impact on quality of life. Current therapies include medical options, such as phototherapy, topical and systemic corticosteroids, topical calcineurin inhibitors, immunomodulators, and antioxidiants, and surgical options. Surgical options provide melanocytic cells to previously depigmented areas and use either tissue grafting or cellular grafting methods. Topical treatments are often insufficient, and many of the current surgical procedures have shown variable response rates...
July 2018: International Journal of Dermatology
https://www.readbyqxmd.com/read/29282672/successful-treatment-of-refractory-vitiligo-with-a-combination-of-khellin-and-308-nm-excimer-lamp-an-open-label-1-year-prospective-study
#12
Samy Fenniche, Anissa Zaouak, Azima Ben Tanfous, Meriem Jrad, Houda Hammami
INTRODUCTION: Phototherapy is the cornerstone of treatment of vitiligo. The 308-nm excimer lamp (EL) induces T cell apoptosis and the stimulation of melanocyte proliferation. Khellin is a furanochromone with a chemical structure close to psoralens. The objective of the study was to evaluate the safety and efficacy of 1-year treatment of recalcitrant vitiligo with a combination of 308-nm EL and khellin. METHODS: Twenty patients with resistant vitiligo were included...
March 2018: Dermatology and Therapy
https://www.readbyqxmd.com/read/29277296/successful-treatment-of-giant-invasive-cutaneous-squamous-cell-carcinoma-by-plum-blossom-needle-assisted-photodynamic-therapy-sequential-with-imiquimod-case-experience
#13
Peiru Wang, Linglin Zhang, Guolong Zhang, Zhongxia Zhou, Haiyan Zhang, Zijun Zhao, Lei Shi, Xiuli Wang
Giant cutaneous squamous cell carcinoma (cSCC) in elderly people is difficult to treat. Herein, we report a case of 96-year-old male who was diagnosed to have giant facial invasive SCC (4cm*4.5cm*2 cm). He was successfully treated with plum-blossom needle assisted photodynamic therapy (PDT) sequential with imiquimod. The patient achieved complete remission after 9 sessions of PDT and 3 months of imiquimod but developed residual vitiligo-like hypopigmentation. There was no recurrence at 18 months of follow-up...
March 2018: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/29230210/checkpoint-blockade-toxicity-and-immune-homeostasis-in-the-gastrointestinal-tract
#14
REVIEW
Michael Dougan
Monoclonal antibodies targeting the regulatory immune "checkpoint" receptors CTLA-4, PD-1, and PD-L1 are now standard therapy for diverse malignancies including melanoma, lung cancer, and renal cell carcinoma. Although effective in many patients and able to induce cures in some, targeting these regulatory pathways has led to a new class of immune-related adverse events. In many respects, these immune toxicities resemble idiopathic autoimmune diseases, such as inflammatory bowel disease, autoimmune hepatitis, rheumatoid arthritis, and vitiligo...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29124007/immunotherapy-shock-with-vitiligo-due-to-nivolumab-administration-as-third-line-therapy-in-lung-adenocarcinoma
#15
Paul Zarogoulidis, Haidong Huang, Theodora Tsiouda, Chrysa Sardeli, Georgia Trakada, Lemonia Veletza, Anastasios Kallianos, Christoforos Kosmidis, Aggeliki Rapti, Liana Papaemmanouil, Dimitrios Hatzibougias, Dimitrios Drougas, Chong Bai, Wolfgang Hohenforst-Schmidt
Non-small cell lung cancer is still diagnosed at late stage due to the lack of early symptoms and methods of diagnostic prevention. In the past ten years several targeted therapies have been introduced or explored. Tyrosine kinase inhibitors and immunotherapy are currently considered the most effective and safe therapies in comparison to the non-specific cytotoxic agents. Regarding tyrosine kinase inhibitors the adverse effects have been fully explored, however; on the other hand for immunotherapy there are still several issues to be clarified...
2017: Respiratory Medicine Case Reports
https://www.readbyqxmd.com/read/29052782/clinical-and-immunologic-evaluation-of-three-metastatic-melanoma-patients-treated-with-autologous-melanoma-reactive-tcr-transduced-t-cells
#16
Tamson Moore, Courtney Regan Wagner, Gina M Scurti, Kelli A Hutchens, Constantine Godellas, Ann Lau Clark, Elizabeth Motunrayo Kolawole, Lance M Hellman, Nishant K Singh, Fernando A Huyke, Siao-Yi Wang, Kelly M Calabrese, Heather D Embree, Rimas Orentas, Keisuke Shirai, Emilia Dellacecca, Elizabeth Garrett-Mayer, Mingli Li, Jonathan M Eby, Patrick J Stiff, Brian D Evavold, Brian M Baker, I Caroline Le Poole, Boro Dropulic, Joseph I Clark, Michael I Nishimura
Malignant melanoma incidence has been increasing for over 30 years, and despite promising new therapies, metastatic disease remains difficult to treat. We describe preliminary results from a Phase I clinical trial (NCT01586403) of adoptive cell therapy in which three patients received autologous CD4+ and CD8+ T cells transduced with a lentivirus carrying a tyrosinase-specific TCR and a marker protein, truncated CD34 (CD34t). This unusual MHC Class I-restricted TCR produces functional responses in both CD4+ and CD8+ T cells...
February 2018: Cancer Immunology, Immunotherapy: CII
https://www.readbyqxmd.com/read/29028121/lupus-like-cutaneous-reaction-following-pembrolizumab-an-immune-related-adverse-event-associated-with-anti-pd-1-therapy
#17
Kimberly Shao, Suzanne McGettigan, Rosalie Elenitsas, Emily Y Chu
PD-1 (programmed cell death-1) inhibitors, used to treat metastatic melanoma and other malignancies, are associated with development of immune-related adverse events in the skin. Such reactions include morbilliform eruptions, vitiligo, alopecia areata and bullous pemphigoid. In this report, we describe a patient who developed a lupus-like cutaneous reaction in the setting of pembrolizumab therapy for metastatic melanoma, adding to the spectrum of reactions which may be observed in association with PD-1 inhibitor therapy...
January 2018: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/28971483/study-of-efficacy-and-safety-of-noncultured-extracted-follicular-outer-root-sheath-cell-suspension-transplantation-in-the-management-of-stable-vitiligo
#18
Pawan Kumar, Neetu Bhari, Manoj K Tembhre, Sujata Mohanty, Sudheer Arava, Vinod K Sharma, Somesh Gupta
BACKGROUND: Noncultured, extracted follicular outer root sheath suspension (NC-EHF-ORS-CS) is a recently introduced technique for the treatment of stable vitiligo. OBJECTIVE: To study the clinical efficacy of this technique and to determine the viability and cell composition of the suspension. METHODS: Twenty-five patients with stable vitiligo were included in this prospective study. Fifty follicles were extracted from occipital scalp and were incubated with trypsin-ethylenediaminetetraacetic acid to separate outer root sheath cells...
February 2018: International Journal of Dermatology
https://www.readbyqxmd.com/read/28852293/simplified-non-cultured-non-trypsinised-epidermal-cell-graft-technique-followed-by-psoralen-and-ultraviolet-a-light-therapy-for-stable-vitiligo
#19
Dilip Kachhawa, Pankaj Rao, Gyaneshwar Kalla
BACKGROUND AND AIMS: Stable vitiligo can be treated by various surgical procedures. Non-cultured melanocyte grafting techniques were developed to overcome the time-consuming process of culture while at the same time providing acceptable results. All the techniques using non-cultured melanocyte transfer involve trypsinisation as an integral step. Jodhpur technique used by the author is autologous, non-cultured, non-trypsinised, epidermal cell grafting. SETTINGS AND DESIGN: The study was conducted on patients visiting the dermatology outpatient department of a tertiary health centre in Western Rajasthan...
April 2017: Journal of Cutaneous and Aesthetic Surgery
https://www.readbyqxmd.com/read/28746020/pembrolizumab-induced-pancytopenia-a-case-report
#20
Dinesh Atwal, Krishna P Joshi, Rahul Ravilla, Fade Mahmoud
INTRODUCTION: Programmed death receptor-1 blockade with pembrolizumab is approved by the US Food and Drug Administration to treat patients with metastatic melanoma. Activating T cells to fight cancer may cause immune-mediated adverse events. Pembrolizumab-induced pancytopenia has not been previously reported in the medical literature, to our knowledge. CASE PRESENTATION: A 52-year-old Caucasian woman with a diagnosis of metastatic melanoma of the rectum experienced multiple adverse events along her course of therapy with pembrolizumab, ranging from colitis, hepatitis, gastritis, and vitiligo after the fifth cycle of pembrolizumab; to knee synovitis after the 14th cycle; and to severe pancytopenia after the 18th cycle of pembrolizumab...
2017: Permanente Journal
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