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Hair And Reconstruction

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https://www.readbyqxmd.com/read/30521888/identification-and-molecular-analysis-of-a-lncrna-hotair-transcript-from-secondary-hair-follicle-of-cashmere-goat-reveal-integrated-regulatory-network-with-the-expression-regulated-potentially-by-its-promoter-methylation
#1
Qian Jiao, Rong H Yin, Su J Zhao, Ze Y Wang, Yu B Zhu, Wei Wang, Yuan Y Zheng, Xian B Yin, Dan Guo, Shi Q Wang, Yan X Zhu, Wen L Bai
The HOTAIR transcript is transcribed from the antisense strand within the HOXC gene cluster, and it is thought to play a role in regulating the inductive capacity of dermal papilla cells during the reconstruction of hair-follicle. In the current investigation, we firstly isolated and characterized a lncRNA-HOTAIR transcript from the secondary hair follicle of cashmere goat. Also, we analyzed its transcriptional pattern and methylation level of HOTAIR gene promoter in secondary hair follicle of cashmere goat during anagen and telogen stages...
December 3, 2018: Gene
https://www.readbyqxmd.com/read/30507888/use-of-modified-islanded-paramedian-forehead-flap-for-complex-periocular-facial-reconstruction
#2
Satyaswarup Tripathy, Akhil Garg, Jerry R John, Ramesh Kumar Sharma
The paramedian forehead flap is a workhorse flap for reconstructing the nose and periorbital regions. Many variants are described including an islanded flap. However, eyebrow reconstruction is not usually performed with these flaps. The authors describe a patient suffering from postburn scarring medial to the left eye, including loss of the left eyebrow. He underwent a single-stage transfer of the paramedian forehead flap. The flap incorporated scalp hair, which restored the missing eyebrow hair after transfer...
November 30, 2018: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/30496844/on-a-new-species-of-titi-monkey-primates-plecturocebus-byrne-et-al-2016-from-alta-floresta-southern-amazon-brazil
#3
Jean P Boubli, Hazel Byrne, Maria N F da Silva, José Silva-Júnior, Rodrigo Costa Araújo, Fabrício Bertuol, Jonas Gonçalves, Fabiano Melo, Anthony B Rylands, Russell A Mittermeier, Felipe E Silva, Stephen D Nash, Gustavo Canale, Raony de M Alencar, Rogerio Rossi, Jeferson Carneiro, Iracilda Sampaio, Izeni P Farias, Horácio Schneider, Tomas Hrbek
The taxonomy of the titi monkeys (Callicebinae) has recently received considerable attention. It is now recognised that this subfamily is composed of three genera with 33 species, seven of them described since 2002. Here, we describe a new species of titi, Plecturocebus, from the municipality of Alta Floresta, Mato Grosso, Brazil. We adopt an integrative taxonomic approach that includes phylogenomic analyses, pelage characters, and locality records. A reduced representation genome-wide approach was employed to assess phylogenetic relationships among species of the eastern Amazonian clade of the Plecturocebus moloch group...
November 26, 2018: Molecular Phylogenetics and Evolution
https://www.readbyqxmd.com/read/30484234/artificial-pigmented-human-skin-created-by-muse-cells
#4
Takeshi Yamauchi, Kenshi Yamasaki, Kenichiro Tsuchiyama, Setsuya Aiba
The skin composes physiological and chemical barrier and renews skin component cells throughout the human life. Melanocytes locate in the basal layer of the epidermis and produce melanin to protect the skin from ultraviolet. Melanin plays key roles in determining human skin and hair color. Melanocyte dysfunction observed in albinism and vitiligo not only causes cosmetic problems but also increases risk of skin cancer. As rejuvenate therapy, embryonic stem (ES) cells and induced pluripotent stem (iPS) cells have been reported to generate melanocytes...
2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/30482080/eyelash-hair-transplantation-with-strip-composite-eyebrow-graft-an-enhancing-technique-in-tarsoconjunctival-flap-eyelid-reconstruction-procedure
#5
Ángel Nava-Castañeda, José Luis Tovilla-Canales, Paolo Solano-Leal, Lilia Garnica-Hayashi
PURPOSE: To describe and evaluate the eyelash transplantation with strip composite eyebrow graft to improve eyelid anatomy in tarsoconjunctival flap eyelid reconstruction procedure. METHODS: Twenty two patients with eyelid tumors managed by local excision and reconstruction using tarsoconjunctival flap reconstruction procedure were included. Eyelash graft was performed during flap division by harvesting a graft from the eyebrow and creating a recipient pocket in the receptor eyelid...
November 27, 2018: Orbit
https://www.readbyqxmd.com/read/30431080/long%C3%A2-term-treatment-with-salicylate-enables-nmda-receptors-and-impairs-ampa-receptors-in-c57bl-6j-mice-inner-hair-cell-ribbon-synapse
#6
Wanming Cui, Haolin Wang, Yu Cheng, Xiaorui Ma, Yu Lei, Xingxing Ruan, Lin Shi, Mei Lv
Salicylate is widely used to produce animal models of tinnitus in mice and/or rats. The side effects on auditory function, including hearing loss and tinnitus, are considered the results of the auditory nerve dysfunction. A recent study indicated that chronic treatment with salicylate for several weeks reduces compressed action potential amplitude, which is contradictory to the studies reporting excessive activation of N‑methyl‑D‑aspartate receptors (NMDAR) in tinnitus‑induced animals. The specific aims of the experiment were to detect the effect of salicylate on the inner hair cells (IHCs), ribbon synapse, as well as the association between the hearing threshold and the number of mismatched ribbon synapses...
November 5, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/30425301/deficiency-of-the-human-cysteine-protease-inhibitor-cystatin-m-e-causes-hypotrichosis-and-dry-skin
#7
Ellen H J van den Bogaard, Michel van Geel, Ivonne M J J van Vlijmen-Willems, Patrick A M Jansen, Malou Peppelman, Piet E J van Erp, Selma Atalay, Hanka Venselaar, Marleen E H Simon, Marieke Joosten, Joost Schalkwijk, Patrick L J M Zeeuwen
PURPOSE: We aimed to assess the biological and clinical significance of the human cysteine protease inhibitor cystatin M/E, encoded by the CTS6 gene, in diseases of human hair and skin. METHODS: Exome and Sanger sequencing was performed to reveal the genetic cause in two related patients with hypotrichosis. Immunohistochemical, biophysical, and biochemical measurements were performed on patient skin and 3D-reconstructed skin from patient-derived keratinocytes. RESULTS: We identified a homozygous variant c...
November 14, 2018: Genetics in Medicine: Official Journal of the American College of Medical Genetics
https://www.readbyqxmd.com/read/30405430/influence-of-magnitude-and-duration-of-altered-gravity-and-readaptation-to-1-g-on-the-structure-and-function-of-the-utricle-in-toadfish-opsanus-tau
#8
Richard Boyle, Yekaterina Popova, Joseph Varelas
Gravity has remained constant during animal evolution and the neural sensory systems detecting acceleration forces have remained remarkably conserved among vertebrates. The utricular organ senses the sum of inertial force due to head translation and head tilt relative to gravitational vertical. Change in gravitational force would be expected to have profound effects on how an organism maintains equilibrium. We characterize the physiology of utricular afferents to applied accelerations in the oyster toadfish, Opsanus tau , in normal 1 g to establish benchmarks, after 1-32-day exposures to 2...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/30369134/-application-effects-of-ct-angiography-and-three-dimensional-reconstruction-technique-in-repairing-scar-around-the-mouth-and-chin-with-expanded-forehead-axial-flap
#9
C D Xia, J D Xue, H P Di, D W Han, D Y Cao, Q Li, F Q Jing, X H Niu
Objective: To explore application effects of CT angiography (CTA) and three-dimensional reconstruction technique in repairing scar around the mouth and chin with expanded forehead axial flap. Methods: From June 2013 to October 2017, 9 patients with hyperplastic scar around the mouth and chin after deep burns on face were admitted to our unit. The sizes of scars of patients ranged from 8 cm×7 cm to 13 cm×8 cm. One cylindrical skin soft-tissue dilator with nominal volume of 400 to 500 mL was implanted in forehead area of each patient...
October 20, 2018: Zhonghua Shao Shang za Zhi, Zhonghua Shaoshang Zazhi, Chinese Journal of Burns
https://www.readbyqxmd.com/read/30300820/360%C3%A2-multiparametric-imaging-atomic-force-microscopy-a-method-for-three-dimensional-nanomechanical-mapping
#10
Haojian Lu, Yongbing Wen, Hao Zhang, Hui Xie, Yajing Shen
Atomic Force Microscopy (AFM) has been intensively used for imaging, characterization and manipulation at the micro- and nanoscale. Taking into account that the material is usually anisotropic, it needs to be characterized in various regions and orientations. Although recent advances of AFM techniques have allowed for large area scan of the sample on a two-dimensional plane, mapping a three-dimensional (3D) sample at a full orientation of 360° remains challenge. This paper reports a multiparametric imaging atomic force microscope via robot technique for 360° mapping and 3D reconstruction of the sample's topography and nanomechanical properties...
January 2019: Ultramicroscopy
https://www.readbyqxmd.com/read/30294542/the-double-stage-delay-multiply-and-sum-image-reconstruction-method-improves-imaging-quality-in-a-led-based-photoacoustic-array-scanner
#11
Moein Mozaffarzadeh, Ali Hariri, Colman Moore, Jesse V Jokerst
Light-emitting diode-based photoacoustic imaging is more compact and affordable than laser-based systems, but it has low power and hence a high number of replicates. Here, we describe double-stage delay-multiply-and-sum (DS-DMAS) to improve image quality collected on a LED-based scanner. DS-DMAS was evaluated experimentally using point targets (in different laterals and depths) as well as a hair and a rabbit eye. This algorithm can compensate for the low SNR of LED-based systems and offer better lateral resolution of about 60%, 25%, higher contrast ratio of about 97%, 34%, and better full-width-half-maximum of about 60%, 25%, versus delay-and-sum) and delay-multiply-and-sum, respectively...
December 2018: Photoacoustics
https://www.readbyqxmd.com/read/30286339/effects-of-tanning-on-the-stable-isotopic-compositions-of-hair
#12
Geoff Koehler, Keith A Hobson
We investigated the effect of tanning on the stable isotopic compositions (CNHOS) of hair keratin. Samples of hair from polar bear (Ursus maritimus) hides were collected before and after the tanning process from a commercial tannery. With the exception of sulphur isotopes, tanning did not alter the stable isotopic compositions of hair. δ34 S values were slightly more positive (1 per mil) in hair that had gone through the tanning process, likely as a result of the tanning agent, alum (Al2 (SO4 )3 ) or exposure to sulphuric acid (H2 SO4 )...
September 24, 2018: Forensic Science International
https://www.readbyqxmd.com/read/30282418/use-of-a-helical-composite-free-flap-for-alar-defect-reconstruction-with-a-supermicrosurgical-technique
#13
Hyung Hwa Jeong, Dong Hoon Choi, Joon Pio Hong, Hyun Suk Suh
The highly contoured nature of the nose and the abundant free margin makes it especially difficult to reconstruct. In this report, we describe the use of a new helical rim free flap technique for the reconstruction of full-thickness nasal alar defects via supermicrosurgery. Briefly, after a wide excision with a margin of 0.7 cm, an alar defect with a size of 1×1×0.5cm was obtained, which included the full thickness of the skin, mucosa, and lower lateral cartilage. Vessel dissection was performed in a straightforward manner, starting from the incision margin for flap harvest, without any further dissection for reach the greater trunk of the superficial temporal artery...
September 2018: Archives of Plastic Surgery
https://www.readbyqxmd.com/read/30213554/skin-irritation-and-sensitization-potential-of-oxidative-hair-dye-substances-evaluated-with-in-vitro-in-chemico-and-in-silico-test-methods
#14
Hanseul Park, Jee-Hyun Hwang, Ji-Seok Han, Byoung-Seok Lee, Yong-Bum Kim, Kyung-Mi Joo, Min-Seok Choi, Sun-A Cho, Bae-Hwan Kim, Kyung-Min Lim
Permanent oxidative hair dyes are widely used but their toxicity is not well-established. Here we aimed to evaluate the skin sensitization and irritation of nine hair dye substances (MAP, MRP-N, RS, PAOX, 2,4-DAPE, 2,6-PYR, PPD, Grey HED and PM) permitted for use in EU and Korea, using in vitro and in chemico and in silico test methods. Skin sensitization was evaluated by the KeratinoSens™ assay, Direct Peptide Reactivity Assay (DPRA) and DEREK. Six of nine dyes tested were determined as sensitizers in common...
November 2018: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/30194332/establishment-of-keratinocyte-cell-lines-from-human-hair-follicles
#15
Tanja Wagner, Maria Gschwandtner, Agata Strajeriu, Adelheid Elbe-Bürger, Johannes Grillari, Regina Grillari-Voglauer, Georg Greiner, Bahar Golabi, Erwin Tschachler, Michael Mildner
The advent of organotypic skin models advanced the understanding of complex mechanisms of keratinocyte differentiation. However, these models are limited by both availability of primary keratinocytes and donor variability. Keratinocytes derived from cultured hair follicles and interfollicular epidermis were immortalized by ectopic expression of SV40 and hTERT. The generated keratinocyte cell lines differentiated into stratified epidermis with well-defined stratum granulosum and stratum corneum in organotypic human skin models...
September 7, 2018: Scientific Reports
https://www.readbyqxmd.com/read/30191601/hairless-regulates-p53-target-genes-to-exert-tumor-suppressive-functions-in-glioblastoma
#16
Lemlem Brook, Patricia Palade, Anas Maatough, Graham Kerr Whitfield, Lis San Emeterio, David Hsieh, Jui-Cheng Hsieh
Glioblastoma (GBM) is the most common malignant brain tumor and is associated with a poor prognosis, with most patients living less than a year after diagnosis. Given that GBM nearly always recurs after conventional treatments, there is an urgent need to identify novel molecular targets. Hairless (HR) is a nuclear factor enriched in the skin and has been previously implicated in hair cycling. HR is also highly expressed in the brain, but its significance is unknown. We found that human hairless gene (HR) expression is significantly decreased in all GBM subtypes compared with normal brain tissue and is predictive of prognosis, which suggests that loss of HR expression can contribute to GBM pathogenesis...
January 2019: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/30186963/temporal-bone-histopathology-of-x-linked-inherited-alport-syndrome
#17
Omer J Ungar, Joseph B Nadol, Felipe Santos
Objective: To describe the histopathologic findings within the human cochlea in X-linked Alport syndrome. Study Design: Histopathologic analysis of cellular elements within the human cochlea by light microscopy. Materials and Methods: A right and a left cochleae of a man with genetically confirmed X-linked Alport syndrome was studied post-mortem. The temporal bones underwent standard processing for histologic examination. The slides were examined by light microscopy...
August 2018: Laryngoscope Investigative Otolaryngology
https://www.readbyqxmd.com/read/30178364/discrimination-of-complex-activation-patterns-in-near-infrared-optical-tomography-with-artificial-neural-networks
#18
Jingjing Jiang, Linda Ahnen, Scott Lindner, Aldo Di Costanzo Mata, Alexander Kalyanov, Felix Scholkmann, Martin Wolf, Salvador Sánchez Majos
Near-infrared optical tomography (NIROT) has great promise for many clinical problems. Here we focus on the study of brain function. During NIROT image reconstruction of brain activity, an inverse problem has to be solved that is sensitive to small superficial perturbations on the head such as e.g. birthmarks on the skin and hair. To consider these perturbations, standard physical modeling is unpractical, since it requires the implementation of detailed information that is generally unavailable. The aim here was to test whether artificial neural networks (ANN) are able to handle such perturbations and thus detect brain activity correctly...
2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/30138955/strontium-isotope-ratios-87-sr-86-sr-of-human-fingernail-clippings-reveal-multiple-location-signals
#19
Christy J Mancuso, James R Ehleringer
RATIONALE: Strontium isotope ratios (87 Sr/86 Sr) in human fingernail keratin tissues have been underexplored for region of origin and travel history reconstruction studies. Here we investigated 87 Sr/86 Sr ratios in fingernail keratin to establish baseline measurements in a resident group and to examine how 87 Sr/86 Sr ratios changed with relocation. METHODS: Fingernail clippings were collected from resident (n = 10) and non-resident/traveler groups (n = 4 and n = 4) that were part of a larger study in Salt Lake City (UT, USA) from 2015 to 2016...
November 30, 2018: Rapid Communications in Mass Spectrometry: RCM
https://www.readbyqxmd.com/read/30138660/evaluation-of-skin-irritation-potentials-of-different-cosmetic-products-in-turkish-market-by-reconstructed-human-epidermis-model
#20
Ozge Kose, Pinar Erkekoglu, Suna Sabuncuoglu, Belma Kocer-Gumusel
Human skin is a protective barrier against the toxic effects of cosmetics. Marketing of cosmetic products with ingredients tested on animals was prohibited in 2013. Since then, safety evaluation of cosmetic products is performed by using alternative in vitro toxicity tests. In vitro 3-D reconstructed human epidermis (RhE) tissue models are now used to define skin irritation/corrosion potentials of cosmetic ingredients and end-products. The main aim of this study was to evaluate skin irritation potentials of topically used cosmetic end-products which were marketed in Turkey during 2015-2017, by using the EpiDerm in vitro 3D-human skin model...
August 20, 2018: Regulatory Toxicology and Pharmacology: RTP
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