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Adrenal metastasis

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https://www.readbyqxmd.com/read/30101011/diagnosis-of-lung-adenocarcinoma-with-left-adrenal-metastasis-via-transesophageal-endoscopic-ultrasound-guided-fine-needle-aspiration-biopsy-a-case-report
#1
Meixuan Liu, Qian Zhang, Haihu Long, Ming Xu, Yi Shou, Zhongliang Guo
Lung cancer is generally diagnosed through traditional bronchoscopy by pulmonologists, whereas data on the application of transesophageal endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) for lung cancer diagnosis in China are very rarely reported. We herein describe a case of a 62-year-old woman who presented with non-productive cough and was found to have a pulmonary mass in the upper lobe of the right lung. The results of positron emission tomography revealed an elevated level of 18 F-fluorodeoxyglucose accumulation (maximum standardized uptake value of 13...
August 2018: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/30079090/sclerotic-bone-metastasis-in-pulmonary-adenocarcinoma
#2
Riyadh Ali Mohammed Hammamy, Khalid Farooqui, Wisam Ghadban
Pulmonary adenocarcinoma is one of the major types of lung cancers in which metastasis is very common and it accounts approximately to one-third of all primary pulmonary cancers. Although a minority of patients with lung cancer are asymptomatic, which gets usually detected in routine chest radiography, most of the patients present with some symptoms. Lung cancer metastasis may occur virtually in every organ system. Patients with non-small-cell lung cancer commonly have extrathoracic metastases to the adrenal glands, liver, brain, bones, and lymph nodes at presentation...
2018: Case Reports in Medicine
https://www.readbyqxmd.com/read/30076415/the-lim1-oncogene-as-a-new-therapeutic-target-for-metastatic-human-renal-cell-carcinoma
#3
Imène Hamaidi, Catherine Coquard, Sabrina Danilin, Valérian Dormoy, Claire Béraud, Sylvie Rothhut, Mariette Barthelmebs, Nadia Benkirane-Jessel, Véronique Lindner, Hervé Lang, Thierry Massfelder
Metastatic clear cell renal cell carcinoma (CCC) remains incurable despite advances in the development of anti-angiogenic targeted therapies and the emergence of immune checkpoint inhibitors. We have previously shown that the sonic hedgehog-Gli signaling pathway is oncogenic in CCC allowing us to identify the developmental Lim1 transcription factor as a Gli target and as a new oncogene in CCC regulating cell proliferation and apoptosis, and promoting tumor growth. In this previous study, preliminary in vitro results also suggested that Lim1 may be implicated in metastatic spread...
August 3, 2018: Oncogene
https://www.readbyqxmd.com/read/30073425/impact-of-number-versus-location-of-metastases-on-survival-in-stage-iv-m1b-non-small-cell-lung-cancer
#4
Amanda Jane Williams Gibson, Haocheng Li, Adrijana D'Silva, Roxana A Tudor, Anifat A Elegbede, Shannon Mary Otsuka, D Gwyn Bebb, Winson Y Cheung
BACKGROUND: To assess the impact of location versus number of extra-pulmonary metastatic sites (EPMS) on survival in stage IV non-small cell lung cancer (NSCLC). METHODS AND MATERIALS: Retrospective analysis was conducted on patients diagnosed during 1999-2013 with stage IV, M1b (AJCC 7th edition) NSCLC using the large, institutional Glans-Look Database, which contains patient demographic, clinical, pathological, treatment, and outcome information. We assessed the impact of location and number of EPMS and identified correlates of overall survival using the Kaplan-Meier method and Cox regression...
August 2, 2018: Medical Oncology
https://www.readbyqxmd.com/read/30053972/transesophageal-approach-to-lung-adrenal-biopsy-and-fiducial-placement-using-endoscopic-ultrasonography-eus-an-interventional-pulmonology-experience-initial-experience-of-the-ucsf-fretoc-fresno-tracheobronchial-oesophageal-center-study-group
#5
Faye M Pais, Raj A Shah, Jose J Vempilly, Sneha Gullapalli, Daya Upadhyay, Michael Peterson, Moishe Liberman, Pravachan Hegde
BACKGROUND: Routine lung cancer surveillance has resulted in early detection of pulmonary nodules and masses. Combined endobronchial ultrasound (EBUS) and trans-esophageal endoscopic ultrasound (EUS) are approved methods for sampling lymph nodes or masses. Furthermore, EUS allows for adrenal sampling as part of staging, and can assist with fiducial placement for stereotactic body radiation therapy (SBRT). OBJECTIVES: Promote use of EUS by interventional pulmonologists in the United States when diagnosing and staging lung cancer or when placing fiducials...
August 2018: Respiratory Medicine
https://www.readbyqxmd.com/read/30038680/imaging-in-a-rare-case-of-neuroendocrine-tumour-with-skin-metastases
#6
Marcin Białecki, Agnieszka Białecka, Kaja Męcińska-Jundziłł, Urszula Adamska, Anna Kasperska, Rafał Czajkowski
Purpose: Disseminated malignancies are a diagnostic and therapeutic challenge that is often encountered in radiology. Finding the primary tumour is crucial for planning proper surgical and oncological treatment. Computed tomography (CT) of the thorax and abdomen is typically the initial examination. However, abdominal magnetic resonance imaging (MRI) or positron emission tomography (PET/CT) or PET/MRI are often subsequently performed. Histopathological examination of metastatic tumours is performed as well, followed by immunohistochemistry...
2018: Polish Journal of Radiology
https://www.readbyqxmd.com/read/30033572/pheochromocytoma-and-paraganglioma-in-fontan-patients-common-more-than-expected
#7
Mi Kyoung Song, Gi Beom Kim, Eun Jung Bae, Young Ah Lee, Hyun-Young Kim, Seung-Kee Min, Jung Hee Kim, Jae-Kyung Won
OBJECTIVE: Pheochromocytoma and paraganglioma (extra-adrenal pheochromocytoma) are rare neuroendocrine tumors that arise from the neuroendocrine cells. Chronic hypoxia is known as a possible cause, and a strong link between cyanotic congenital heart disease and these tumors has been reported. However, reports of phechromocytoma/paraganglioma in Fontan patients were scarce. We herein report seven cases of phechromocytoma/paraganglioma after Fontan operation at a single tertiary center...
July 22, 2018: Congenital Heart Disease
https://www.readbyqxmd.com/read/30031460/practical-approach-to-adrenal-imaging
#8
REVIEW
Khaled M Elsayes, Sally Emad-Eldin, Ajaykumar C Morani, Corey T Jensen
Various pathologies can affect the adrenal gland. Noninvasive cross-sectional imaging is used for evaluating adrenal masses. Accurate diagnosis of adrenal lesions is critical, especially in cancer patients; the presence of adrenal metastasis changes prognosis and treatment. Characterization of adrenal lesions predominantly relies on morphologic and physiologic features to enable correct diagnosis and management. Key diagnostic features to differentiate benign and malignant adrenal lesions include presence/absence of intracytoplasmic lipid, fat cells, hemorrhage, calcification, or necrosis and locoregional and distant disease; enhancement pattern and washout values; and lesion size and stability...
August 2018: Urologic Clinics of North America
https://www.readbyqxmd.com/read/30013635/correlation-of-ct-signs-with-lymphatic-metastasis-and-pathology-of-neuroblastoma-in-children
#9
Xinxian Zhang, Chenglong Li, Chao Xu, Xiangdong Hao, Xiao Yu, Qiancheng Li
Correlation between computed tomography (CT) signs, lymphatic metastasis and pathological features of neuroblastoma (NB) in children was investigated. A total of 374 child patients diagnosed with NB via CT scan and pathological section in Department of Pediatric of Xuzhou Children's Hospital from March 2011 to January 2017 were collected, and their clinical data were retrospectively analyzed. According to CT signs, NB calcification and invasion to surrounding tissues were evaluated, and the tumor site, tumor size, lymphatic metastasis, pathological types and clinical prognosis were analyzed...
August 2018: Oncology Letters
https://www.readbyqxmd.com/read/30008900/correlation-between-ct-features-of-adrenocortical-and-adrenal-medullary-tumors-and-expression-of-mir-96-in-serum
#10
Yongyun Xu, Zhenfang Wang, Yangang Bi, Zuyun Duan, Xuewang Yue
Correlation between CT features of adrenocortical and adrenal medullary tumors and the expression of miR-96 in serum were investigated. A total of 230 patients with adrenocortical tumors and 194 patients with adrenal medullary tumors were selected in Dongying People's Hospital from August 2013 to August 2017. The two groups of patients underwent CT examination, and the signs and symptoms were recorded. The expression of miR-96 in the serum of the two groups was detected by RT-PCR, and the correlation between the expression of serum miR-96 and CT features was analyzed...
August 2018: Oncology Letters
https://www.readbyqxmd.com/read/30007965/chronic-sleep-restriction-impairs-the-antitumor-immune-response-in-mice
#11
Beatriz Helena Pizarro De Lorenzo, Ronni Rômulo Novaes E Brito, Thatiane Paslar Leal, Nycole Piqueira Garcia, Rafaela Miranda Martins Dos Santos, Anuska Marcelino Alvares-Saraiva, Elizabeth Cristina Perez Hurtado, Tânia Carolina Braga Dos Reis, Beatriz Duarte Palma
OBJECTIVES: Sleep regulates immune function reciprocally and can affect the parameters that are directly involved in the immune response. Sleep deprivation is considered to be a stress-causing factor and is associated with impaired immune activity. It causes increased glucocorticoid concentrations by activating the hypothalamic-pituitary-adrenal axis; this can lead to a series of disorders that are associated with the prolonged or increased secretion of these hormones. The aim of this study was to evaluate the effects of sleep restriction (SR) on the development of pulmonary experimental metastasis and the modulation of the tumor immune response...
July 13, 2018: Neuroimmunomodulation
https://www.readbyqxmd.com/read/29981322/corticotropin-releasing-factor-suppresses-glioma-progression-by-upregulation-of-long-non-coding-rna-p21
#12
Jianbo Yang, Xilun Gan, Beibei Tan, Jie Wang, Yue Chen
Corticotropin-releasing factor (CRF) plays a key role in neuroendocrine regulation of hypothalamo-pituitary-adrenal axis under normal condition and stress by binding to CRF receptor1 (CRFR1). CRF and its receptors have been reported in many types of tumors. Little is known about the role of CRF in the development of glioma. And lincRNA-p21 was reported to act as a role in progression of some cancers. The aim of the present study was to investigate the levels of CRF in glioma, and explore the link between CRF and lincRNA-p21 in this disease...
July 4, 2018: Life Sciences
https://www.readbyqxmd.com/read/29967708/vaginal-bleeding-as-initial-presentation-of-an-aggressive-renal-cell-carcinoma-a-case-report-and-review-of-the-literature
#13
Antonio R Jimenez, Maria Del Mar Rivera Rolon, Eduardo Eyzaguirre, Cecilia Clement
Introduction: Renal cell carcinoma is the third most common urogenital cancer. In some patients, it can metastasize to distant organs. Metastasis to the vagina is extremely rare. Case Presentation: A 54-year-old female with unremarkable history presented to the clinic with a chief complaint of vaginal bleeding. Further examination identified a pedunculated mass on the vaginal wall. Histologic examination revealed a metastatic clear cell renal cell carcinoma. Radiological studies then revealed a left renal mass and bilateral adrenal masses...
2018: Case Reports in Pathology
https://www.readbyqxmd.com/read/29960124/a-systematic-review-and-meta-analysis-of-clinicopathologic-factors-linked-to-oncologic-outcomes-for-renal-cell-carcinoma-with-tumor-thrombus-treated-by-radical-nephrectomy-with-thrombectomy
#14
REVIEW
Liangyou Gu, Hongzhao Li, Zihuan Wang, Baojun Wang, Qingbo Huang, Xiangjun Lyu, Dan Shen, Yu Gao, Yang Fan, Xintao Li, Yongpeng Xie, Songliang Du, Kan Liu, Lu Tang, Cheng Peng, Xin Ma, Xu Zhang
BACKGROUND: There remain discrepancies over the factors that influence oncologic outcomes after radical nephrectomy with thrombectomy (RNTE). To assess significant predictors of oncologic outcomes after RNTE from a systematic review and meta-analysis. METHODS: A comprehensive search of PubMed, Embase, Cochrane Library and Web of Science was performed to identify eligible studies. The endpoints included cancer-specific survival (CSS), overall survival (OS), and recurrence-free survival (RFS)...
June 21, 2018: Cancer Treatment Reviews
https://www.readbyqxmd.com/read/29940420/simultaneous-peritoneal-and-retroperitoneal-splenosis-mimics-metastatic-right-adrenal-mass
#15
Abdelwahab Hashem, M A Elbaset, Mohamed H Zahran, Yasser Osman
INTRODUCTION: Right retroperitoneal splenosis is rare with few reported cases. We report, here, the case of simultaneous peritoneal and retroperitoneal splenosis mimics metastatic right adrenal mass. PRESENTATION OF CASE: A 28-year-old man who had previously undergone post traumatic splenectomy at childhood and subsequently presented with an large incidental non-functioning right adrenal mass with presence of extra-hepatic peritoneal focal lesion diagnosed as metastasis by magnetic resonance imaging (MRI)...
June 5, 2018: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29938331/bilateral-adrenal-abnormalities-imaging-review-of-different-entities
#16
REVIEW
Meshal Ali Alshahrani, Mnahi Bin Saeedan, Tariq Alkhunaizan, Ibtisam Musallam Aljohani, Fahad Mohammed Azzumeea
Bilateral adrenal abnormalities are not infrequently encountered during routine daily radiology practice. The differential diagnoses of bilateral adrenal abnormalities include neoplastic and non-neoplastic entities. The bilateral adrenal tumors include metastasis, lymphoma, neuroblastoma, pheochromocytoma, adenoma, and myelolipoma. Non-neoplastic bilateral adrenal masses include infectious processes and haematomas. There are different diffuse bilateral adrenal changes such as adrenal atrophy, adrenal enlargement, adrenal calcifications, and altered adrenal enhancement...
June 25, 2018: Abdominal Radiology
https://www.readbyqxmd.com/read/29929757/a-clinical-prediction-model-to-estimate-the-metastatic-potential-of-pheochromocytoma-paraganglioma-ases-score
#17
Yoon Young Cho, Mi Kyung Kwak, Seung-Eun Lee, Seong Hee Ahn, Hyeonmok Kim, Sunghwan Suh, Beom-Jun Kim, Kee-Ho Song, Jung-Min Koh, Jae Hyeon Kim, Seung Hun Lee
BACKGROUND: Malignant pheochromocytoma and paraganglioma can be defined only after the development of metastases in nonchromaffin tissues. There is no single clinical parameter that is sufficiently reliable to predict metastatic potential, so our goal was to develop a prediction model based on multiple clinical parameters. METHODS: The baseline age, size, extra-adrenal location, secretory type score was calculated in a retrospective cohort study comprising 333 patients with pheochromocytoma and paraganglioma...
June 18, 2018: Surgery
https://www.readbyqxmd.com/read/29928263/prolactin-producing-pituitary-carcinoma-hypopituitarism-and-graves-disease-report-of-a-challenging-case-and-literature-review
#18
Rita Bettencourt-Silva, Josué Pereira, Sandra Belo, Daniela Magalhães, Joana Queirós, Davide Carvalho
Introduction: The diagnosis of pituitary carcinoma is very rare, requires the evidence of metastatic disease, and has a poor overall survival. Malignant prolactinoma frequently requires dopamine agonist therapy, pituitary surgery, radiotherapy, and even chemotherapy. Case description: A 19-year-old female presented with galactorrhea, primary amenorrhea, and left hemianopsia. Complementary study detected hyperprolactinemia and a pituitary macroadenoma with cavernous sinus invasion and suprasellar growth...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29906237/ct-guided-percutaneous-core-biopsy-for-assessment-of-morphologically-normal-adrenal-glands-showing-high-fdg-uptake-in-patients-with-lung-cancer
#19
Guillaume Chassagnon, Souhail Bennani, Gaël Freche, Pierre Magdeleinat, Audrey Mansuet-Lupo, Marie-Pierre Revel
OBJECTIVE: Increased fludeoxyglucose (FDG) uptake in morphologically normal adrenal glands on positron emission tomography-CT (PET-CT) is a diagnostic challenge with major implications on treatment. The purpose of this retrospective study was to report our experience of CT-guided percutaneous core biopsy of morphologically normal adrenal glands showing increased FDG uptake in a context of lung cancer. METHODS: Biopsies for non-enlarged adrenal glands showing increased FDG uptake in lung cancer patients performed at our institution from December 2014 to December 2016 were retrospectively analyzed...
July 25, 2018: British Journal of Radiology
https://www.readbyqxmd.com/read/29904467/bringing-sasi-back-single-session-selective-arterial-secretin-injection-and-transarterial-embolization-of-intrahepatic-pancreatic-neuroendocrine-metastasis-in-a-men-1-patient
#20
Jawad S Hussain, Ravi N Srinivasa, Anthony Hage, Rudra Pampati, Jeffrey Forris Beecham Chick
SASI (selective arterial secretin injection) is a form of ASVS (arterial stimulation and venous sampling) used to localize pancreatic gastrinomas. This report aims to review the protocol for SASI and demonstrate its utility in localizing functional and nonfunctional gastrinomas. Even if a patient has a pancreatic mass and a laboratory profile fitting a specific endocrine syndrome, these may or may not be associated as has been previously demonstrated with adrenal vein sampling. We present a case where a patient underwent simultaneous SASI and bland embolization of a hepatic metastasis to facilitate partial pancreatectomy for Zollinger-Ellison syndrome...
April 2018: Radiology Case Reports
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