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https://www.readbyqxmd.com/read/29031194/the-prevalence-and-characteristics-of-epilepsy-in-patients-with-multiple-sclerosis-in-nordland-county-norway
#1
Espen Benjaminsen, Kjell-Morten Myhr, Karl B Alstadhaug
PURPOSE: The prevalence of epilepsy among patients with multiple sclerosis (MS) has been found higher than in the general population. Although cortical pathology may be involved, the causal link between MS and epileptic seizures is still unclear. We aimed to identify and describe the patients with active epilepsy in a previously described population based MS-cohort. METHODS: Medical records of all patients with MS in Nordland County on January 1, 2010, were scrutinizing for evidence of comorbid seizures and epilepsy...
October 6, 2017: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/29031145/small-molecule-mediated-upregulation-of-ccr7-ameliorates-murine-experimental-autoimmune-encephalomyelitis-by-accelerating-t-cell-homing
#2
Xin Li, Tingting Lu, Wenwen Xue, Yixuan Wang, Qiong Luo, Huiming Ge, Renxiang Tan, Yan Shen, Qiang Xu
Impairing the infiltration of immune cells into the CNS is a promising target for suppressing the development of multiple sclerosis (MS) and its animal model experimental autoimmune encephalomyelitis (EAE). Here, we found that oral administration of a synthetic small molecular compound Fc24 showed potential preventive effects on the development of EAE, including the reduction in EAE severity and a delay in the onset of the disease. Fc24 facilitated the accumulation of both CD4(+) and CD8(+) T cells within spleen and lymph nodes, while having no effect on MOG-specific T cell responses...
October 11, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/29029375/treatment-and-disease-management-of-multiple-sclerosis-patients-a-review-for-nurse-practitioners
#3
Cortnee Roman, Kara Menning
BACKGROUND AND PURPOSE: This review discusses the role of the nurse practitioner (NP) in evaluating the clinical effects, potential side effects, and monitoring requirements for treatment options in multiple sclerosis (MS) and provides guidance on how to help patients understand these issues. METHODS: A literature search was conducted on PubMed to identify publications on monitoring and disease management of MS patients. Additional resources included drug information web sites and package inserts...
October 2017: Journal of the American Association of Nurse Practitioners
https://www.readbyqxmd.com/read/29029203/prognostic-significance-of-computed-tomography-criteria-for-pulmonary-veno-occlusive-disease-in-systemic-sclerosis-pulmonary-arterial-hypertension
#4
Michelle J Connolly, Sharif Abdullah, Deborah A Ridout, Benjamin E Schreiber, Jamanda A Haddock, J Gerry Coghlan
Objectives: SSc-pulmonary arterial hypertension (SSc-PAH) is associated with worse response to therapy and survival when compared with idiopathic PAH. It is suggested that the vasculopathy in SSc may involve postcapillary pulmonary venules resulting in pulmonary veno-occlusive disease (PVOD). This may underlie the lower gas transfer and worse outcome on therapy. We sought to test whether CT signs of PVOD (CTS-PVOD) were frequent in SSc-PAH and whether they were associated with pulmonary oedema on therapy and worse survival...
September 26, 2017: Rheumatology
https://www.readbyqxmd.com/read/29028904/considerations-for-clinical-neuropsychological-evaluation-in-amyotrophic-lateral-sclerosis
#5
Susan C Woolley, Beth K Rush
The clinical neuropsychologist has the opportunity to be uniquely involved in the evaluation and treatment of individuals with amyotrophic lateral sclerosis (ALS). We review the current literature that defines cognitive and behavioral symptoms in ALS, including current knowledge of the neuropathological and genetic underpinning for these symptoms. There are unique considerations for clinical neuropsychological evaluation and clinical research in ALS and we highlight these in this review. Specifically, we shed light on special factors that contribute to our understanding of cognitive and behavioral impairment in ALS, including co-morbid symptoms, differential diagnosis, and considerations for longitudinal tracking of phenotypes...
September 28, 2017: Archives of Clinical Neuropsychology: the Official Journal of the National Academy of Neuropsychologists
https://www.readbyqxmd.com/read/29028840/polymorphism-of-keratin-1-associates-with-systemic-lupus-erythematosus-and-systemic-sclerosis-in-a-south-chinese-population
#6
Weiguang Luo, Bin Zhou, Qizhi Luo, Huilong Fang, Xiaoxia Zuo, Yizhou Zou
Both systemic lupus erythematosus (SLE) and systemic sclerosis (SSc) diseases are related to the genetic and environmental factors, causing damage to the skin. The mutations of keratin 1 gene (KRT1) were reported to associate with skin diseases. The single-nucleotide polymorphism (SNP, rs14024) and the indel polymorphism (cds-indel, rs267607656), consisting mostly of the common haplotypes and could be used for genotyping of KRT1. We used the PCR with sequence specific primers (PCR-SSP) to determine the genotype of KRT1 in 164 SLE, 99 SSc patients, and 418 healthy controls...
2017: PloS One
https://www.readbyqxmd.com/read/29028499/fasciculations-in-nerve-and-muscle-disorders-a-prospective-study-of-muscle-ultrasound-compared-to-electromyography
#7
M T Johansson, H R Ellegaard, H Tankisi, A Fuglsang-Frederiksen, E Qerama
OBJECTIVES: We examined the clinical utility of muscle ultrasound (MUS) in detecting fasciculations in patients with nerve and muscle disorders (NMD) and investigated the impact on diagnostic sensitivity when combining electromyography (EMG) and MUS. METHODS: We included 58 consecutive patients suspected to have NMD and 38 healthy subjects (HS). Patients and HS underwent MUS in 14 skeletal and two bulbar muscles and the video recordings of the MUS were anonymised...
September 22, 2017: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/29027962/novel-therapeutics-for-multiple-sclerosis-designed-by-parasitic-worms
#8
REVIEW
Aakanksha Dixit, Akane Tanaka, Judith M Greer, Sheila Donnelly
The evolutionary response to endemic infections with parasitic worms (helminth) was the development of a distinct regulatory immune profile arising from the need to encapsulate the helminths while simultaneously repairing tissue damage. According to the old friend's hypothesis, the diminished exposure to these parasites in the developed world has resulted in a dysregulated immune response that contributes to the increased incidence of immune mediated diseases such as Multiple Sclerosis (MS). Indeed, the global distribution of MS shows an inverse correlation to the prevalence of helminth infection...
October 13, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29027843/the-impact-of-vascular-risk-factors-on-brain-volume-and-lesion-load-in-patients-with-early-multiple-sclerosis
#9
Alexander Pichler, Michael Khalil, Christian Langkammer, Daniela Pinter, Stefan Ropele, Siegrid Fuchs, Gerhard Bachmaier, Christian Enzinger, Franz Fazekas
BACKGROUND: Vascular risk factors (VRF) in multiple sclerosis (MS) patients have been associated with lower brain volumes. It is currently unknown if this association already exists in early MS and how it develops over time. METHODS: We identified 82 patients with clinically isolated syndrome (CIS) ( n = 61) or with early relapsing-remitting MS ( n = 21) and assessed their VRF including arterial hypertension, hyperlipidaemia, diabetes mellitus and smoking. We analysed T2-lesion load, normalized brain volume (NBV), cortical grey (cGMV) and white matter volumes (WMV), thalamic and basal ganglia volumes at baseline and follow-up magnetic resonance imaging (MRI) and assessed the percentage of brain volume change (PBVC) using SIENA...
October 1, 2017: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/29027840/male-factor-infertility-and-risk-of-multiple-sclerosis-a-register-based-cohort-study
#10
Clara Helene Glazer, Sandra Søgaard Tøttenborg, Aleksander Giwercman, Elvira Vaclavik Bräuner, Michael L Eisenberg, Ditte Vassard, Melinda Magyari, Anja Pinborg, Lone Schmidt, Jens Peter Bonde
BACKGROUND: Gender, possibly due to the influence of gonadal hormones, is presumed to play a role in the pathogenesis of multiple sclerosis (MS), but no studies have evaluated whether male infertility is associated with MS. OBJECTIVE: To study the association between male factor infertility and prevalent as well as incident MS. METHOD: Our cohort was established by linkage of the Danish National in vitro fertilization (IVF) registry to The Danish Multiple Sclerosis Registry and consisted of 51,063 men whose partners had undergone fertility treatment in all public and private fertility clinics in Denmark between 1994 and 2015...
October 1, 2017: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/29027515/-a-boy-with-a-white-striped-knee-on-a-radiograph
#11
M G Mentink, R J P Weber, F H Jansen
A 10-year-old boy presented at the radiology department with pain in the right knee. Radiographs of the knee revealed dens metaphyseal bands and subchondral epiphyseal sclerosis as a result of periodic bisphosphonate administration for the treatment of Legg-Calvé-Perthes disease three years ago.
2017: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/29027376/adenosine-a2a-receptor-agonist-ameliorates-eae-and-correlates-with-th1-cytokine-induced-blood-brain-barrier-dysfunction-via-suppression-of-mlck-signaling-pathway
#12
Ying Liu, Marwan Alahiri, Bianca Ulloa, Boxun Xie, Saud A Sadiq
INTRODUCTION: Multiple sclerosis (MS) disease activity is associated with blood-brain barrier (BBB) disruption, which is mediated by inflammatory cytokines released by CD4+ lymphocytes. To assess the effects of adenosine A2A receptors on BBB permeability in vitro and in vivo. METHODS: A2A receptor expression was detected by immunostaining in experimental autoimmune encephalomyelitis (EAE) C57BL/6 mice immunized with myelin oligodendrocyte glycoprotein (MOG)35-55 , and human MS brain...
October 12, 2017: Immunity, Inflammation and Disease
https://www.readbyqxmd.com/read/29027112/field-synopsis-and-re-analysis-of-systematic-meta-analyses-of-genetic-association-studies-in-multiple-sclerosis-a-bayesian-approach
#13
Jae Hyon Park, Joo Hi Kim, Kye Eun Jo, Se Whan Na, Michael Eisenhut, Andreas Kronbichler, Keum Hwa Lee, Jae Il Shin
To provide an up-to-date summary of multiple sclerosis-susceptible gene variants and assess the noteworthiness in hopes of finding true associations, we investigated the results of 44 meta-analyses on gene variants and multiple sclerosis published through December 2016. Out of 70 statistically significant genotype associations, roughly a fifth (21%) of the comparisons showed noteworthy false-positive rate probability (FPRP) at a statistical power to detect an OR of 1.5 and at a prior probability of 10(-6) assumed for a random single nucleotide polymorphism...
October 12, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/29027012/causes-of-death-survival-and-risk-factors-of-mortality-in-thai-patients-with-early-systemic-sclerosis-inception-cohort-study
#14
Suparaporn Wangkaew, Narawudt Prasertwitayakij, Arintaya Phrommintikul, Saowanee Puntana, Juntima Euathrongchit
Inception cohort study regarding the causes of death and risk factors for mortality in patients with early systemic sclerosis (SSc), especially diffuse SSc (dcSSc) has not been well elucidated. Therefore, the aim of our study was to determine the causes of death, survival rates, and risk factors for mortality in Thai patients with early SSc of whom the majority belonged to the dcSSc subset. We used an inception cohort of early-SSc patients seen between January 2010 and August 2014. All patients were evaluated for clinical and laboratory data at the study entry and then every 6 months...
October 12, 2017: Rheumatology International
https://www.readbyqxmd.com/read/29027011/let-s-make-microglia-great-again-in-neurodegenerative-disorders
#15
REVIEW
Marie-Victoire Guillot-Sestier, Terrence Town
All of the common neurodegenerative disorders-Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis and prion diseases-are characterized by accumulation of misfolded proteins that trigger activation of microglia; brain-resident mononuclear phagocytes. This chronic form of neuroinflammation is earmarked by increased release of myriad cytokines and chemokines in patient brains and biofluids. Microglial phagocytosis is compromised early in the disease process, obfuscating clearance of abnormal proteins...
October 12, 2017: Journal of Neural Transmission
https://www.readbyqxmd.com/read/29027004/blood-lymphocyte-subsets-identify-optimal-responders-to-ifn-beta-in-ms
#16
Raquel Alenda, Lucienne Costa-Frossard, Roberto Alvarez-Lafuente, Carmen Espejo, Eulalia Rodríguez-Martín, Susana Sainz de la Maza, Noelia Villarrubia, Jordi Río, María I Domínguez-Mozo, Xavier Montalban, José C Álvarez-Cermeño, Luisa M Villar
Response to interferon-beta (IFN-beta) treatment is heterogeneous in multiple sclerosis (MS). We aimed to search for biomarkers predicting no evidence of disease activity (NEDA) status upon IFN-beta treatment in MS. 119 patients with relapsing-remitting MS (RRMS) initiating IFN-beta treatment were included in the study, and followed prospectively for 2 years. Neutralizing antibodies (NAb) were explored in serum samples obtained after 6 and 12 months of IFN-beta treatment. Soluble cytokines and blood lymphocytes were studied in basal samples by ELISA and flow cytometry, respectively...
October 12, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/29026971/is-impaired-cerebral-vasoreactivity-an-early-marker-of-cognitive-decline-in-multiple-sclerosis-patients
#17
Aude Metzger, Emmanuelle Le Bars, Jeremy Deverdun, François Molino, Bénédicte Maréchal, Marie-Christine Picot, Xavier Ayrignac, Clarisse Carra, Luc Bauchet, Alexandre Krainik, Pierre Labauge, Nicolas Menjot de Champfleur
OBJECTIVE: The link between cerebral vasoreactivity and cognitive status in multiple sclerosis remains unclear. The aim of the present study was to investigate a potential decrease of cerebral vasoreactivity in multiple sclerosis patients and correlate it with cognitive status. METHODS: Thirty-three patients with multiple sclerosis (nine progressive and 24 remitting forms, median age: 39 years, 12 males) and 22 controls underwent MRI with a hypercapnic challenge to assess cerebral vasoreactivity and a neuropsychological assessment...
October 12, 2017: European Radiology
https://www.readbyqxmd.com/read/29026001/understanding-a-role-for-hypoxia-in-lesion-formation-and-location-in-the-deep-and-periventricular-white-matter-in-small-vessel-disease-and-multiple-sclerosis
#18
REVIEW
Santiago Martinez Sosa, Kenneth J Smith
The deep and periventricular white matter is preferentially affected in several neurological disorders, including cerebral small vessel disease (SVD) and multiple sclerosis (MS), suggesting that common pathogenic mechanisms may be involved in this injury. Here we consider the potential pathogenic role of tissue hypoxia in lesion development, arising partly from the vascular anatomy of the affected white matter. Specifically, these regions are supplied by a sparse vasculature fed by long, narrow end arteries/arterioles that are vulnerable to oxygen desaturation if perfusion is reduced (as in SVD, MS and diabetes) or if the surrounding tissue is hypoxic (as in MS, at least)...
October 15, 2017: Clinical Science (1979-)
https://www.readbyqxmd.com/read/29025830/randomised-controlled-pilot-trial-of-an-exercise-plus-behaviour-change-intervention-in-people-with-multiple-sclerosis-the-step-it-up-study
#19
Sara Hayes, Marcin Kacper Uszynski, Robert W Motl, Stephen Gallagher, Aidan Larkin, John Newell, Carl Scarrott, Susan Coote
OBJECTIVE: To investigate feasibility of multiple sclerosis (MS) exercise guidelines for inactive people with MS (PwMS) and to examine preliminary efficacy for walking. To investigate effect of augmenting that intervention with education based on social cognitive theory (SCT). DESIGN: Pilot multicentre, double-blind, randomised, parallel, controlled trial. SETTING: Community-delivered programme. PARTICIPANTS: Sixty-five physically inactive PwMS walked independently, scored 0-3 on the Patient Determined Disease Steps Scale, had no MS relapse or change in MS medication in 12 weeks...
October 12, 2017: BMJ Open
https://www.readbyqxmd.com/read/29025548/percutaneous-therapy-in-pericardial-diseases
#20
REVIEW
Bernhard Maisch, Arsen D Ristić, Sabine Pankuweit, Petar Seferovic
Interventional procedures for pericardial diseases include pericardiocentesis, drainage of pericardial effusion, intrapericardial therapy, and percutaneous balloon pericardiotomy or percutaneous pericardiostomy. Echocardiographic and fluoroscopic guidance have greatly increased safety and feasibility. Several devices for pericardiocentesis have been tested (PerDucer, PeriAttacher, visual puncture systems, Grasper, Scissors, and Reverse slitter), mainly to facilitate access to the pericardium in the absence of effusion for epicardial ablations or left atrial appendage ligation...
November 2017: Cardiology Clinics
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