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https://www.readbyqxmd.com/read/29232371/treatment-effect-of-mtor-inhibition-on-tissue-composition-of-renal-angiomyolipomas-in-tuberous-sclerosis-complex-tsc
#1
Susanne Brakemeier, Lars Vogt, Lisa Adams, Bianca Zukunft, Gerd Diederichs, Bernd Hamm, Klemens Budde, Marcus R Makowski
PURPOSE: Tuberous sclerosis complex (TSC)-associated renal angiomyolipoma (AML) have a high lifetime risk of acute bleeding. MTOR-inhibitors are a promising novel treatment for TSC-AML, however adequate response to therapy can be difficult to assess. Early changes in MRI signal may serve as a novel early indicator for a satisfactory response to mTOR-inhibitor therapy of AML. MATERIALS AND METHODS: Thirty-eight patients with the definite diagnosis of tuberous sclerosis receiving everolimus therapy and n = 19 patients without specific therapy were included...
2017: PloS One
https://www.readbyqxmd.com/read/29231495/-relapsing-remitting-multiple-sclerosis-at-remission-stage-treated-with-acupuncture-a-randomized-controlled-trial
#2
Chunchen Wang, Zhigang Chen, Linpeng Wang, Xinyu Ma, Yi Xing, Aitong Li, Fan Zhang, Tao Zhang
OBJECTIVE: To evaluate the differences in the therapeutic effects on relapsing-remitting multiple sclerosis (RRMS) at remission stage between acupuncture at acupoints and shallow needling therapy at the nearby points. METHODS: Forty-two patients of RRMS were randomized into an observation group and a control group, 21 cases in each one. In the observation group, besides the basic treatment, acupuncture was applied according to WANG Leting's empirical prescriptions as "the empirical ten needles" "thirteen needles of the governor vessel" "twelve needles of hand and foot" as well as the symptomatic points...
June 12, 2017: Zhongguo Zhen Jiu, Chinese Acupuncture & Moxibustion
https://www.readbyqxmd.com/read/29230685/calcitriol-reverses-the-down-regulation-pattern-of-tuberous-sclerosis-complex-genes-in-an-in-vitro-calcification-model
#3
Eraldo Fonseca Dos Santos Junior, Roberta Rodrigues de Lemos Gitirana, Darlene Paiva Bezerra, João Ricardo Mendes de Oliveira
Tuberous sclerosis complex (TSC) is a neurocutaneous syndrome with autosomal dominant inheritance, and most of the cases are related to loss of function of the TSC1 and TSC2 genes. TSC may occur with a wide range of clinical findings and skin, kidney, brain, and heart are the most commonly affected organs. Brain calcifications in TSC are also described and reported as diffuse and without pattern of symmetry or bilaterality. Recently, a new discovery opened the possibility of using vitamin D (VitD) for treating cerebral calcifications...
December 11, 2017: Journal of Molecular Neuroscience: MN
https://www.readbyqxmd.com/read/29229891/cost-effectiveness-of-oral-agents-in-relapsing-remitting-multiple-sclerosis-compared-to-interferon-based-therapy-in-saudi-arabia
#4
Mai F Alsaqa'aby, Varun Vaidya, Noura Khreis, Thamer Al Khairallah, Ahmed H Al-Jedai
BACKGROUND: Promising clinical and humanistic outcomes are associated with the use of new oral agents in the treatment of relapsing-remitting multiple sclerosis (RRMS). This is the first cost-effectiveness study comparing these medications in Saudi Arabia. OBJECTIVES: We aimed to compare the cost-effectiveness of fingolimod, teriflunomide, dimethyl fumarate, and interferon (IFN)-b1a products (Avonex and Rebif) as first-line therapies in the treatment of patients with RRMS from a Saudi payer perspective...
November 2017: Annals of Saudi Medicine
https://www.readbyqxmd.com/read/29229342/parahippocampectomy-as-a-new-surgical-approach-to-mesial-temporal-lobe-epilepsy-due-to-hippocampal-sclerosis-a-pilot-randomized-comparative-clinical-trial
#5
Mario Arturo Alonso-Vanegas, Iván D Freire Carlier, Daniel San-Juan, Alma Rosa Martínez NPsych, Carlos Trenado
BACKGROUND AND OBJECTIVE: The parahippocampal gyrus (PHG) plays an important role in the epileptogenic pathways of mTLE-HS, it´s resection could be preventing epileptic seizures with less complications. Evaluate the initial efficacy and safety of anterior temporal lobectomy (ATL), selective amygdalo-hipppocampectomy (SAH) and parahippocampectomy (PHC) surgical approaches in mTLE-HS. METHODS: This was a randomized comparative pilot clinical trial (2008-2011) that included patients with mTLE-HS who underwent: ATL, trans-T3 SAH, and trans-T3 PHC...
December 8, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29229192/-late-onset-systemic-sclerosis-a-retrospective-study-of-27-patients-diagnosed-after-the-age-of-70
#6
A Achille, L Journeau, O Espitia, J Connault, A Espitia-Thibault, C Durant, F Perrin, M-A Pistorius, A Néel, M Hamidou, C Agard
BACKGROUND: The aim of this study was to describe special features of patients with systemic sclerosis (SSc) diagnosed after the age of 70. PATIENTS AND METHODS: This is a retrospective study of patients aged above 70 years at the time of diagnosis of SSc and followed at an internal medicine unit between 2000 and 2015. Co-morbidities and clinical characteristics were analyzed, as well as survival at 1, 2 and 3 years. RESULTS: Of 246 patients, 27 (11%) were included (89% women, 96% Caucasians, age 78...
December 8, 2017: Annales de Dermatologie et de Vénéréologie
https://www.readbyqxmd.com/read/29228563/riluzole-a-potential-therapeutic-intervention-in-human-brain-tumor-stem-like-cells
#7
Swetlana Sperling, Thiha Aung, Sabine Martin, Veit Rohde, Milena Ninkovic
A small subpopulation of tumor stem-like cells has the capacity to initiate tumors and mediate radio- and chemoresistance in diverse cancers hence also in glioblastoma (GBM). It has been reported that this capacity of tumor initiation in the brain is mainly dependent on the body's nutrient supply. This population of so-called brain tumor initiating or brain tumor stem-like cells (BTSCs) is able to extract nutrients like glucose with a higher affinity. Riluzole, a drug approved for treating amyotrophic lateral sclerosis (ALS), was reported to possess anticancer properties, affecting the glutamate metabolism...
November 14, 2017: Oncotarget
https://www.readbyqxmd.com/read/29228214/oestrogen-receptor-%C3%AE-ligand-acts-on-cd11c-cells-to-mediate-protection-in-experimental-autoimmune-encephalomyelitis
#8
Roy Y Kim, Darian Mangu, Alexandria S Hoffman, Rojan Kovash, Eunice Jung, Noriko Itoh, Rhonda Voskuhl
Oestrogen treatments are neuroprotective in a variety of neurodegenerative disease models. Selective oestrogen receptor modifiers are needed to optimize beneficial effects while minimizing adverse effects to achieve neuroprotection in chronic diseases. Oestrogen receptor beta (ERβ) ligands are potential candidates. In the multiple sclerosis model chronic experimental autoimmune encephalomyelitis, ERβ-ligand treatment is neuroprotective, but mechanisms underlying this neuroprotection remain unclear. Specifically, whether there are direct effects of ERβ-ligand on CD11c+ microglia, myeloid dendritic cells or macrophages in vivo during disease is unknown...
December 8, 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/29227148/structural-abnormalities-and-altered-regional-brain-activity-in-multiple-sclerosis-with-simple-spinal-cord-involvement
#9
Ping Yin, Yi Liu, Hua Xiong, Yongliang Han, Shambhu Kumar Sah, Chun Zeng, Jingjie Wang, Yongmei Li
OBJECTIVE: To assess the changes of the structural and functional abnormalities in multiple sclerosis with simple spinal cord involvement (MS-SSCI) by using resting-state functional magnetic resonance imaging (RS-fMRI), voxel based morphology (VBM) and diffusion tensor tractography. METHODS: The amplitude of low-frequency fluctuation (ALFF) of 22 patients with MS-SSCI and 22 healthy controls (HCs) matched for age, gender and education were compared by using RS-fMRI...
December 11, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/29226779/increased-cerebrospinal-fluid-albumin-and-immunoglobulin-a-fractions-forecast-cortical-atrophy-and-longitudinal-functional-deterioration-in-relapsing-remitting-multiple-sclerosis
#10
Julia Kroth, Dumitru Ciolac, Vinzenz Fleischer, Nabin Koirala, Julia Krämer, Muthuraman Muthuraman, Felix Luessi, Stefan Bittner, Gabriel Gonzalez-Escamilla, Frauke Zipp, Sven G Meuth, Sergiu Groppa
BACKGROUND: Currently, no unequivocal predictors of disease evolution exist in patients with multiple sclerosis (MS). Cortical atrophy measurements are, however, closely associated with cumulative disability. OBJECTIVE: Here, we aim to forecast longitudinal magnetic resonance imaging (MRI)-driven cortical atrophy and clinical disability from cerebrospinal fluid (CSF) markers. METHODS: We analyzed CSF fractions of albumin and immunoglobulins (Ig) A, G, and M and their CSF to serum quotients...
December 1, 2017: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/29226778/a-multicenter-randomized-controlled-trial-of-two-group-education-programs-for-fatigue-in-multiple-sclerosis-short-and-medium-term-benefits
#11
Cinda L Hugos, Zunqiu Chen, Yiyi Chen, Aaron P Turner, Jodie Haselkorn, Toni Chiara, Sean McCoy, Christopher T Bever, Michelle H Cameron, Dennis Bourdette
Background Fatigue occurs in 75%-95% of people with multiple sclerosis (MS) and is frequently reported as the most disabling symptom. A multicomponent group program of six weekly 2-hour sessions, Fatigue: Take Control (FTC), was developed from an international MS fatigue management guideline. Objective To determine whether FTC is associated with greater improvements in fatigue than MS: Take Control (MSTC), a similarly structured general MS education program. Methods This four-site, parallel, single-blind, randomized controlled trial compared FTC and MSTC in 204 ambulatory participants with MS...
December 1, 2017: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/29226728/the-efficacy-and-safety-of-riluzole-for-neurodegenerative-movement-disorders-a-systematic-review-with-meta-analysis
#12
Jia Liu, Lu-Ning Wang
Neurodegenerative movement disorders mainly include Parkinson's disease, atypical parkinsonisms, Huntington disease, and hereditary ataxia. Riluzole is the only drug approved by the US Food and Drug Administration for amyotrophic lateral sclerosis. The neuroprotective effects of riluzole have been observed in experimental models of neurodegenerative movement disorders. In this paper, we aimed to systematically analyze the efficacy and safety of riluzole for patients with neurodegenerative movement disorder...
November 2018: Drug Delivery
https://www.readbyqxmd.com/read/29226621/cenerimod-a-novel-selective-s1p1-receptor-modulator-with-unique-signaling-properties
#13
Luca Piali, Magdalena Birker-Robaczewska, Cyrille Lescop, Sylvie Froidevaux, Nicole Schmitz, Keith Morrison, Christopher Kohl, Markus Rey, Rolf Studer, Enrico Vezzali, Patrick Hess, Martine Clozel, Beat Steiner, Martin H Bolli, Oliver Nayler
Sphingosine-1-phosphate receptor 1 (S1P1 ) modulators sequester circulating lymphocytes within lymph nodes, thereby preventing potentially pathogenic autoimmune cells from exiting into the blood stream and reaching inflamed tissues. S1P1 receptor modulation may thus offer potential to treat various autoimmune diseases. The first nonselective S1P1-5 receptor modulator FTY720/fingolimod/Gilenya® has successfully demonstrated clinical efficacy in relapsing forms of multiple sclerosis. However, cardiovascular, hepatic, and respiratory side-effects were reported and there is a need for novel S1P1 receptor modulators with better safety profiles...
December 2017: Pharmacology Research & Perspectives
https://www.readbyqxmd.com/read/29226505/evaluating-the-association-between-enlarged-perivascular-spaces-and-disease-worsening-in-multiple-sclerosis
#14
Michele Cavallari, Svetlana Egorova, Brian C Healy, Miklos Palotai, Juan Carlos Prieto, Mariann Polgar-Turcsanyi, Shahamat Tauhid, Mark Anderson, Bonnie Glanz, Tanuja Chitnis, Charles R G Guttmann
BACKGROUND AND PURPOSE: Enlarged perivascular spaces (EPVSs) have been associated with relapses and brain atrophy in multiple sclerosis (MS). We investigated the association of EPVS with clinical and MRI features of disease worsening in a well-characterized cohort of relapsing-remitting MS patients prospectively followed for up to 10 years. METHODS: Baseline EPVSs were scored on 1.5T MRI in 30 converters to moderate-severe disability, and 30 nonconverters matched for baseline characteristics...
December 11, 2017: Journal of Neuroimaging: Official Journal of the American Society of Neuroimaging
https://www.readbyqxmd.com/read/29226387/systemic-sclerosis
#15
REVIEW
Yoshihide Asano
Systemic sclerosis (SSc) is a multisystem autoimmune disease characterized by vasculopathy and tissue fibrosis of the skin and various internal organs. A series of genetic and epidemiological studies have demonstrated that SSc onset is determined by the accumulation of predisposing factors related to environmental influences, while genetic factors affect the susceptibility to and the severity of this disease. This notion has been confirmed by recent advance in animal models. The initial trigger of SSc is believed to be autoimmune attacks to endothelial cells, which occur in individuals with the genetic susceptibility to autoimmune diseases and/or the cumulative exposure to certain SSc-related environmental influences...
December 10, 2017: Journal of Dermatology
https://www.readbyqxmd.com/read/29226305/association-between-scalp-and-intracerebral-electroencephalographic-seizure-onset-patterns-a-study-in-different-lesional-pathological-substrates
#16
Hideaki Tanaka, Hui Ming Khoo, François Dubeau, Jean Gotman
OBJECTIVE: Our purpose was to determine the correlation between scalp electroencephalography (EEG) and intracerebral EEG (iEEG) seizure-onset patterns in patients with focal lesional epilepsy to determine whether scalp seizure-onset patterns can be specific to intracerebral seizure-onset patterns and to lesion type. METHODS: We retrospectively analyzed 61 patients with focal epilepsy and a structural magnetic resonance imaging (MRI)-visible lesion, who first underwent extensive scalp recordings and then iEEG studies (stereo-EEG) for presurgical evaluation, and who showed an iEEG seizure onset in the lesional/perilesional area...
December 11, 2017: Epilepsia
https://www.readbyqxmd.com/read/29226040/creutzfeldt-cell-rich-glioblastoma-a-diagnostic-dilemma
#17
Zain Boghani, William J Steele, Matthew D Cykowski, Leomar Y Ballester, Gavin Britz
Differentiating demyelinating conditions from neoplastic conditions can pose a significant challenge. There are a number of reports in the literature of large ring-enhancing, space-occupying lesions that were initially considered neoplastic or infectious but, on further review, were deemed demyelinating. Creutzfeldt-Peters cells (CPC) are reactive astrocytes with fragmented nuclear inclusions that are routinely seen in multiple sclerosis (MS) and generally exclude the diagnosis of glioblastoma (GB). The patient is a 78-year-old man with a history of prostate cancer, which was treated with radiation therapy, who presented with altered mental status...
October 5, 2017: Curēus
https://www.readbyqxmd.com/read/29226021/holmes-tremor-secondary-to-a-stabbing-lesion-in-the-midbrain
#18
Rubens Gisbert Cury, Egberto Reis Barbosa, Christian Freitas, Luis Filipe de Souza Godoy, Wellingson Silva Paiva
Background: The development of Holmes tremor (HT) after a direct lesion of the midbrain has rarely been reported in the literature, although several etiologies have been linked with HT, such as stroke, brainstem tumors, multiple sclerosis, head trauma, or infections. Phenomenology Shown: A 31-year-old male, having been stabbed in the right eye, presented with a rest and action tremor in the left upper limb associated with left hemiparesis with corresponding post-contrast volumetric magnetic resonance imaging T1 with sagittal oblique reformation showing the knife trajectory reaching the right midbrain...
2017: Tremor and Other Hyperkinetic Movements
https://www.readbyqxmd.com/read/29225852/physical-rehabilitation-modulates-micrornas-involved-in-multiple-sclerosis-a-case-report
#19
Annamaria Vallelunga, Carmine Berlingieri, Marco Ragusa, Michele Purrello, Maria Rosaria Stabile, Maria Consiglia Calabrese, Julio Cesar Morales-Medina, Beniamino Palmieri, Tommaso Iannitti
This study shows that neuromuscular taping improves gait, balance, pain and ability to walk and conduct daily activities in a multiple sclerosis patient. It is the first study to identify a panel of miRNAs modulated throughout rehabilitation using neuromuscular taping in a multiple sclerosis patient.
December 2017: Clinical Case Reports
https://www.readbyqxmd.com/read/29225800/recommendations-for-imaging-based-diagnosis-and-management-of-renal-angiomyolipoma-associated-with-tuberous-sclerosis-complex
#20
REVIEW
María José Buj Pradilla, Teresa Martí Ballesté, Roser Torra, Felipe Villacampa Aubá
Renal angiomyolipomas are found in up to 80% of tuberous sclerosis complex (TSC) patients. Although these tumours are usually asymptomatic, lesions >3 cm in diameter are prone to bleeding and up to 10% of TSC patients may experience a massive and potentially fatal retroperitoneal haemorrhage. Diagnosis can be complicated because of the initial lack of symptoms and the fat-poor content of atypical renal angiomyolipomas. After diagnosis, tumour growth and the emergence of new tumours must be monitored. Treatment with mammalian target of rapamycin (mTOR) inhibitors can reduce tumour size and is indicated in patients with TSC-associated renal angiomyolipomas >3 cm in diameter...
December 2017: Clinical Kidney Journal
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