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Vaccine HPV

Nigel Hawkes
No abstract text is available yet for this article.
August 9, 2018: BMJ: British Medical Journal
Laura F Wetherill, Christopher W Wasson, Gemma Swinscoe, David Kealy, Richard Foster, Stephen Griffin, Andrew Macdonald
Despite the availability of prophylactic vaccines the burden of human papillomavirus (HPV) associated malignancy remains high and there is a need to develop additional therapeutic strategies to complement vaccination. We have previously shown that the poorly characterised E5 oncoprotein forms a virus-coded ion channel or viroporin that was sensitive to the amantadine derivative rimantadine. We now demonstrate that alkylated imino sugars, which have antiviral activity against a number of viruses, inhibit E5 channel activity in vitro...
August 7, 2018: Antiviral Research
Alexandra Jana H Freeman, Cristina Gamboa, Jeanne A Darbinian, Ramey D Littell, Sandra Torrente
OBJECTIVE: To estimate the rate of human papillomavirus (HPV) vaccine completion by race and ethnicity. METHODS: In this retrospective cohort study, we analyzed females aged 11-26 years who initiated HPV vaccination from 2008 through 2012 in a community-based health care system in California. Vaccine completion was defined as having received at least three injections. Demographic data including age, race, ethnicity, and language preferences were obtained. Among Hispanic patients, acculturation was categorized as low or high using written and spoken Spanish vs English language as a proxy...
August 6, 2018: Obstetrics and Gynecology
Jennifer Tabler, Laryssa Mykyta, Rachel M Schmitz, Akiko Kamimura, Dora A Martinez, Ruben D Martinez, Paloma Flores, Karina Gonzalez, Alvaro Marquez, Gladys Marroquin, Andy Torres
U.S.-Mexico border communities are uniquely vulnerable to sexually transmitted infection (STI) transmission given the economic and social challenges these communities face. This study examines how marginalized statuses of U.S. border residents are associated with STI awareness and sexual behaviors. We surveyed low-income residents receiving STI testing and/or HIV/AIDS care in the lower Rio Grande Valley of southernmost Texas. Respondents aged 18+ took a self-administered survey available in English or Spanish in a clinic waiting room (N = 282)...
August 9, 2018: Journal of Community Health
C W Easterly, F Alarid-Escudero, E A Enns, S Kulasingam
BACKGROUND: Sexual mixing between heterogeneous population subgroups is an integral component of mathematical models of sexually transmitted infections (STIs). This study compares the fit of different mixing representations to survey data and the impact of different mixing assumptions on the predicted benefits of hypothetical human papillomavirus (HPV) vaccine strategies. METHODS: We compared novel empirical (data-driven) age mixing structures with the more commonly-used assortative-proportionate (A-P) mixing structure...
August 6, 2018: Vaccine
(no author information available yet)
In February 2018, recognizing the suboptimal rates of human papillomavirus (HPV) vaccination in the United States, the assistant secretary for health of the US Department of Health and Human Services charged the National Vaccine Advisory Committee (NVAC) with providing recommendations on how to strengthen the effectiveness of national, state, and local efforts to improve HPV vaccination coverage rates. In the same month, the NVAC established the HPV Vaccination Implementation Working Group and assigned it to develop these recommendations...
August 9, 2018: Public Health Reports
Alireza Sanchooli, Khosrow Aghayipour, Bahman Abedi Kiasari, Alireza Samarbaf-Zadeh, Ataollah Ghadiri, Manoocher Makvandi
Human papillomavirus 16 is considered a causative agent of genital cancers. Since there is no decisive treatment, the only approach is vaccination of high-risk group. Due to the high cost, the current HPV vaccines are not affordable in developing countries. This study aimed to produce a chimeric L1/L2 protein in Pichia Pastoris system. To develop the VLPs retrieved from chimeric L1/L2 protein HPV-16, first, a cross-neutralizing epitope of HPV-16 L2 gene was inserted into L1 HPV-16 gene. The chimeric L1/L2 HPV-16 was inserted in pPICZA plasmid and expressed in Pichia pastoris (P...
August 9, 2018: Protein and Peptide Letters
Greetje J Tack, Nanne K H de Boer
No abstract text is available yet for this article.
July 31, 2018: Inflammatory Bowel Diseases
Eduardo Lazcano-Ponce, Leticia Torres-Ibarra, Aurelio Cruz-Valdez, Jorge Salmerón, Tonatiuh Barrientos-Gutiérrez, Javier Prado-Galbarro, Margaret Stanley, Nubia Muñoz, Rolando Herrero, Mauricio Hernández-Ávila
Background: There is limited data regarding the duration of immunity induced by different HPV vaccination schedules and the immunogenicity of a booster dose of both bivalent (bHPV) or quadrivalent (qHPV) HPV vaccine. Methods: Follow-up of a non-randomized clinical trial to evaluate the 5-years antibody persistence of the bHPV in girls (9-10 years) and women (18-24 years). Non-inferiority of the two- versus three-dose schedule among girls was evaluated at months 54 (n=639) and 64 (n=990)...
August 1, 2018: Journal of Infectious Diseases
Helle Kiellberg Larsen, Louise T Thomsen, Merete Haedersdal, Christian Dehlendorff, Søren Schwartz Sørensen, Susanne K Kjaer
Genital warts (GWs) are a risk factor for subsequent human papillomavirus (HPV)-related anogenital cancers. In this register-based, prospective cohort study, we estimated the risk of GWs in renal transplant recipients (RTRs) compared with a non-transplanted cohort. In a nationwide database, we identified first-time RTRs in Denmark during 1996-2015. For each RTR, 50 age- and sex-matched non-transplanted individuals were selected from the population registry. Information on GWs, socio-demographic characteristics, HPV vaccination, and other causes of immunosuppression was retrieved from registries...
August 6, 2018: American Journal of Transplantation
Rihab Gamaoun
Background: Rapid changes in lifestyle induced by globalization have brought about changes in sexual behaviour, especially among younger generations. These changes may lead to considerable consequences on the prevalence of sexually transmitted disease, including human papillomavirus (HPV) infection. Aims: The objective of this study is to provide a systematic review of peer-reviewed literature on human papillomavirus (HPV) vaccine awareness and acceptability in the Arab states of the Middle East and North Africa region...
July 29, 2018: Eastern Mediterranean Health Journal, la Revue de Santé de la Méditerranée Orientale
Lauren Rockliffe, Emily McBride, Catherine Heffernan, Alice S Forster
This study sought to identify barriers and facilitators to delivery of human papillomavirus (HPV) vaccination in schools. Four focus groups were conducted with 28 staff members, from four National Health Service school-aged vaccination (SAV) teams in London. Data were analyzed using thematic analysis. School engagement and support, and understanding and education about the vaccination (or conversely, a lack of) were identified as both barriers and facilitators. Limited school and team resources, fear of the vaccination, and poor consent form return were identified as barriers...
August 5, 2018: Journal of School Nursing: the Official Publication of the National Association of School Nurses
Elsebeth Lynge, Malene Skorstengaard, Charlotte Lynderup Lübker, Lise Thamsborg
No abstract text is available yet for this article.
August 6, 2018: Expert Review of Vaccines
Geneviève Rail, Luisa Molino, Caroline Fusco, Moss Edward Norman, LeAnne Petherick, Jessica Polzer, Fiona Moola, Mary Bryson
RéSUMé: OBJECTIF: L'objectif était d'étudier le déploiement des discours sur la vaccination contre les VPH (VVPH) et leur impact sur les filles, les parents, les infirmiers/infirmières et les médecins canadiens. MéTHODES: Des entrevues ont été réalisées avec des participant(e)s (n = 146) de quatre provinces canadiennes. Une analyse poststructuraliste du discours a permis d'examiner les campagnes de VVPH et les transcriptions d'entrevues pour documenter la façon dont les participant(e)s interprètent les VVPH et se positionnent comme sujets au sein des discours de l'industrie ou des agences de santé publique...
August 3, 2018: Canadian Journal of Public Health. Revue Canadienne de Santé Publique
M Jesus Purriños-Hermida, María Isolina Santiago-Pérez, Mercedes Treviño, Rafaela Dopazo, Angelina Cañizares, Isolina Bonacho, Matilde Trigo, M Eva Fernández, Ana Cid, David Gómez, Patricia Ordóñez, Amparo Coira, M J Armada, Magdalena Porto, Sonia Perez, Alberto Malvar-Pintos
Bivalent human papillomavirus (HPV) vaccine was incorporated into the childhood vaccination calendar in Galicia, Spain in 2008. The objectives of this study were to estimate direct, indirect and total effectiveness of HPV vaccine and to identify sexual habits changes in the post-vaccination period in Galicia, Spain.Endocervical scrapings of 745 women attending 7 Health Areas of the Galician Public Health Service were collected in the post-vaccination period, from 2014-2017. Two groups were studied: women born between 1989 and 1993 (n = 397) and women born in 1994 or later (n = 348)...
2018: PloS One
Rachel Fernandes, Beth K Potter, Julian Little
BACKGROUND: Persistent infection with certain subtypes of human papillomavirus (HPV) is a necessary cause of cervical cancer. Although two prophylactic vaccines have been licensed in Canada against cancerous subtypes of HPV, vaccine uptake has been lower than anticipated. The primary objective of this study was to determine the acceptability of catch-up HPV vaccination to undergraduate university women under the age of 25, by assessing their perceptions of HPV vaccination. METHODS: A total of 401 University of Ottawa female undergraduate students participated in a cross-sectional bilingual web-based survey on HPV vaccination...
August 2, 2018: BMC Women's Health
Noriyo Kaneko
BACKGROUND: The prevalence of cervical cancer among women aged 20-30 years has been increasing. A better understanding of the factors correlated with cervical cancer screening is vital to better identify suitable candidates and develop effective interventions. However, few studies have examined factors correlated with cervical cancer screening using a quantitative research design. Thus, this study aimed to assess the prevalence of and factors correlated with cervical cancer screening among unmarried and sexually active Japanese women aged 20-29 years...
July 31, 2018: BMC Women's Health
I Manini, E Montomoli
Human papillomavirus is the most common sexually transmitted infection, and skin-to-skin genital contact is sufficient for virus transmission. Cervical cancer is the second-most common cancer in women living in less developed regions, with an estimated 445,000 new cases in 2012 and 230,000 deaths every year. Until now, more than 200 types of HPV have been identified, and about 15 types (HPV-16, -18, -31, -33, -35, -39, -45, -51, -52, -56, -58, -59, -66, -68, -82) have been shown to cause cervical cancer because they are able to transform infected cells into malignant tumor cells...
July 2018: Annali di Igiene: Medicina Preventiva e di Comunità
Inga I Hitzeroth, Aleyo Chabeda, Mark P Whitehead, Marcus Graf, Edward P Rybicki
Human papillomaviruses (HPVs) are the causative agents of cervical cancer, the fourth most prevalent cancer in women worldwide. The major capsid protein L1 self-assembles into virus-like particles (VLPs), even in the absence of the minor L2 protein: such VLPs have successfully been used as prophylactic vaccines. There remains a need, however, to develop cheaper vaccines that protect against a wider range of HPV types. The use of all or parts of the L2 minor capsid protein can potentially address this issue, as it has sequence regions conserved across several HPV types, which can elicit a wider spectrum of cross-neutralizing antibodies...
2018: Frontiers in Bioengineering and Biotechnology
Emmanuel Chandler, Lili Ding, Pamina Gorbach, Eduardo L Franco, Darron A Brown, Lea E Widdice, David I Bernstein, Jessica A Kahn
PURPOSE: The aims of this study were to determine prevalence of and factors associated with any human papillomavirus (HPV) and vaccine-type HPV among young men after vaccine introduction, stratified by vaccination status. METHODS: Young men were recruited from clinical sites from 2013 to 2015, completed a survey, and were tested for 36 anogenital HPV types. We determined factors associated with ≥1 HPV type among all participants, and vaccine-type HPV (HPV6, 11, 16, and/or 18) among all, vaccinated and unvaccinated participants, using multivariable regression...
July 2018: Journal of Adolescent Health: Official Publication of the Society for Adolescent Medicine
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