Xuan Xu, Hao Sun, Junyu Luo, Xuewen Cheng, Wenqi Lv, Wei Luo, Wan-Jin Chen, Zhi-Qi Xiong, Jing-Yu Liu
Primary familial brain calcification (PFBC) is an inherited neurodegenerative disorder mainly characterized by progressive calcium deposition bilaterally in the brain, accompanied by various symptoms, such as dystonia, ataxia, parkinsonism, dementia, depression, headaches, and epilepsy. Currently, the etiology of PFBC is largely unknown, and no specific prevention or treatment is available. During the past 10 years, six causative genes (SLC20A2, PDGFRB, PDGFB, XPR1, MYORG, and JAM2) have been identified in PFBC...
December 5, 2022: Neuroscience Bulletin