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Loose skin

Burton I Korelitz, Bernard Partiula, Kelly Teagle, Arun Swaminath, Judy Schneider, Martin Ellington, Guillaume Stoffels
Objective: To seek the habits of pediatricians by which anorectal skin tags (AST) of Crohn's disease might be overlooked. Methods: Questionnaires were sent to pediatricians affiliated with the Northwell Health System. Results: Based on the responses, the majority of pediatricians did feel the abdomen of children presenting with abdominal pain or diarrhea but did not spread the buttocks to seek the presence of AST unless there was rectal pain, rectal bleeding, or, in some cases, loose stools...
November 2018: Inflammatory Intestinal Diseases
Takefumi Mori, Shinichi Sato, Ikuko Oba-Yabana, Takuo Hirose, Satoshi Kinugasa, Yoshikazu Muroya, Kohei Ota, Shingo Nakayama, Hannah Nakamura, Junichi Tani, Chika Takahashi, Sadayoshi Ito
Exit-site infection poses a risk for peritonitis and can shorten peritoneal dialysis (PD) vintage. A loose fit of the skin around the catheter at the exit site can push bacteria surrounding the catheter into the subcutaneous tunnel. Negative-pressure wound therapy (NPWT) has been used to hasten healing of the wound after an operation or to treat pressure ulcers. We hypothesized that NPWT could speed the healing of the exit site and tighten the fit of the skin around the catheter. Using a V.A.C. Therapy system [vacuum-assisted closure (KCI, San Antonio, TX, U...
November 2018: Advances in Peritoneal Dialysis
İlker Karacan, Reyhan Diz Küçükkaya, Fatma Nur Karakuş, Seyhun Solakoğlu, Aslıhan Tolun, Veysel Sabri Hançer, Eda Tahir Turanlı
OBJECTIVE: Autosomal recessive cutis laxa type IIA (ARCL2A) is a rare congenital disorder characterized by loose and elastic skin, growth and developmental delay, and skeletal anomalies. It is caused by biallelic mutations in ATP6V0A2 . Those mutations lead to increased pH in secretory vesicles and thereby to impaired glycosyltransferase activity and organelle trafficking. We aimed to identify the genetic and molecular cause of the unexpected haematological findings in a Turkish family...
November 26, 2018: Turkish Journal of Haematology: Official Journal of Turkish Society of Haematology
Joseph Michaels
Excess thigh laxity is a problem for many patients following significant weight loss. Thigh laxity has both vertical and horizontal components that require correction to optimize the aesthetic appearance of the thigh. The vertical vector is best corrected first with a lower body lift or extended abdominoplasty. The remaining loose skin in the medial thigh can then be removed using a horizontal vector resulting in a vertical incision. Residual vertical skin excess is also removed parallel to the groin crease...
January 2019: Clinics in Plastic Surgery
Takunori Shimazaki, Yuzu Kuwahara, Masaya Kimoto, Shinsuke Hara, Hiroyuki Yomo
Photoplethysmography (PPG) is simple, non-invasive and unobtrusive, so it has been commonly used for heart rate (HR) sensing during exercise. PPG-based HR sensor can be applied for almost any part of human body where there is an artery close to the sensor, just by stabilizing it on the skin surface with belt. However, in order to make the HR sensor stable even during vigorous exercise, it requires a high fastening belt pressure, which results in discomfort for the sensor wearer. In this paper, we investigate the relationship between fastening belt pressure and accuracy for PPG-based HR sensors put on two positions such as forearm and wrist...
July 2018: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
Weibin Wu, Christian Lutz, Simon Mersch, Richard Thelen, Christian Greiner, Guillaume Gomard, Hendrik Hölscher
Lizards of the genus Scincus are widely known under the common name sandfish due to their ability to swim in loose, aeolian sand. Some studies report that this fascinating property of sandfish is accompanied by unique tribological properties of their skin such as ultra-low adhesion, friction and wear. The majority of these reports, however, is based on experiments conducted with a non-standard granular tribometer. Here, we characterise microscopic adhesion, friction and wear of single sandfish scales by atomic force microscopy...
2018: Beilstein Journal of Nanotechnology
Waseem M Hajjar, Areej S Alrajeh, Lulwah S Alturki, Sami A Al-Nassar, Adnan W Hajjar
Cutis laxa (CL) is a rare connective tissue disease characterized by a loose, wrinkled, and inelastic skin. Here, we report an unusual presentation in a 15-year-old male patient who is a known patient of CL who presented with bilateral pneumothorax. He was successfully managed initially by chest tube insertion and then he was treated surgically with bilateral staged thoracoscopy, apical bullectomy, and pleurodesis with full uneventful recovery.
October 2018: Annals of Thoracic Medicine
Saori Nojo, Yasuo Ihara
Despite the generally low level of inter-population genetic differentiation in humans as compared with great apes, it has long been acknowledged that there is a considerable amount of geographic variations in human phenotypes, for example, skin pigmentation, cranial morphology, and soft-tissue facial morphology, to name but a few. Indeed, recent studies have suggested that the extent of inter-population diversity in some human phenotypes is greater than expected from random drift alone. Such an excess of phenotypic diversity is often attributed to adaptation to local environment...
November 2, 2018: Journal of Theoretical Biology
Dong Wook Kim, Sang-Woo Kim, Unyong Jeong
It is familiar to everyone that human skin and hair easily lose electrons and cause static electricity as they undergo friction with other materials. Such natural regenerative substances take a high ranking in the triboelectric series. Even though the static electricity of regenerative natural substances has been a long-term curiosity in human history, it is not yet clear which of their components causes the positive static charges. This study reveals that lipid layers on the surface of regenerative substances (skin, hair, leaves, cells) and even synthetic lipids are responsible for this positive static electricity and shows that it is possible to manufacture lipid-based triboelectric nanogenerators (TENGs)...
November 2, 2018: Advanced Materials
Rong Yang, Xiao-Dong Yang, Fan Shu, Hao Zhang
OBJECTIVE: To explore clinical effects of Kirschner wire with hole transverse fixation combined with titanium cable purse string suture in treating refractory fracture of patellar comminuted fracture. METHODS: From January 2014 to January 2016, 17 comminuted fracture treated by Kirschner wire with hole transverse fixation combined with titanium cable purse string suture were retrospectively analyzed, including 10 males and 7 females aged from 28 to 67 years old with an average of (48...
October 25, 2018: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
Hiroyuki Oshiba, Toshiro Itsubo, Masatoshi Komatsu, Shigeharu Uchiyama, Hiroyuki Kato
Background: Capitellar osteochondritis dissecans (OCD) is a focal injury of the articular cartilage involving separation of a segment of cartilage from the subchondral bone that is infrequently encountered in the dominant-side elbow of adolescent throwing athletes1,2 . The literature suggests that patients may achieve better short and mid-term results when treated with certain types of surgical procedures3,4 . Selection of the appropriate surgical method should be based on the International Cartilage Repair Society (ICRS) OCD classification system5 ...
March 28, 2018: JBJS Essential Surgical Techniques
Ryan J Marek, Kristine J Steffen, David R Flum, Alfons Pomp, Walter J Pories, J Peter Rubin, Bruce M Wolfe, James E Mitchell
BACKGROUND: Bariatric surgery usually results in substantial weight loss and a reduction in medical comorbidities. Many patients, as a consequence of the weight loss, subsequently evidence loose, redundant skin. OBJECTIVES: This investigation seeks to examine the prevalence of body contouring surgery (BCS) by patients approximately 4 to 5 years after Roux-en-Y gastric bypass surgery. Demographics, change in BMI, and psychosocial variables were also used to predict body dissatisfaction, desire for BCS, and patients who reported obtaining BCS...
July 31, 2018: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
Alyssa L Ritter, Carey McDougall, Cara Skraban, Livija Medne, Emma C Bedoukian, Stephanie B Asher, Jorune Balciuniene, Colleen D Campbell, Samuel W Baker, Elizabeth H Denenberg, Sarah Mazzola, Sarah K Fiordaliso, Ian D Krantz, Paige Kaplan, Lynne Ierardi-Curto, Avni B Santani, Elaine H Zackai, Kosuke Izumi
Xia-Gibbs syndrome (XGS) is a recently described neurodevelopmental disorder due to heterozygous loss-of-function AHDC1 mutations. XGS is characterized by global developmental delay, intellectual disability, hypotonia, and sleep abnormalities. Here we report the clinical phenotype of five of six individuals with XGS identified prospectively at the Children's Hospital of Philadelphia, a tertiary children's hospital in the USA. Although all five patients demonstrated common clinical features characterized by developmental delay and characteristic facial features, each of our patients showed unique clinical manifestations...
August 27, 2018: American Journal of Medical Genetics. Part A
M Balevi, S Ozturk
Background/Aim: Ulnar compressive neuropathy is the second most common nerve compression in the upper extremity. Although numerous operative procedures have been defined for the treatment of cubital tunnel syndrome (CuTS), the best operative intervention remains controversial. The aim of this study is to discuss the efficacy of a modified simple decompression (MSD) of the ulnar nerve in the treatment of CuTS. Materials and Methods: Each patient was preoperatively examined, and the following data were recorded: initial complaint, duration of symptoms, and presence of Tinel's sign around the elbow, results of provocation by the elbow flexion test, and results of electrodiagnostic studies...
August 2018: Nigerian Journal of Clinical Practice
G Kerch
This mini-review article is focused on publications devoted to the changes in water binding energy and content of bound water in biological tissues during aging processes, when bound water lost from the hydration layer becomes free water. Bound water is released during cataractogenesis. In skin, water bound to proteins and other biomacromolecules becomes more mobile with increasing skin age. Extracellular to intracellular water ratio increases with age and was associated with muscle cell atrophy. Bound water concentration decreases with age in hydrated human bone and can be correlated with the strength and toughness of the bone...
October 15, 2018: International Journal of Biological Macromolecules
Muriel Cario
DDR1 and DDR2 are expressed in skin but their expression differs according to the skin compartment, epidermis, dermis, hypodermis and to the embryonic origin of the cells. In skin, it seems that during physiological processes such as wound healing or pathological processes such as tumorigenesis or systemic sclerosis development only one of the DDR is dysregulated. Furthermore, the altered DDR in pathological process is not necessarily the DDR implicated in basal homeostasis. Indeed, in epidermis, while DDR1 is the main DDR involved in melanocyte homeostasis, DDR2 seems to be the main DDR implicated in melanoma...
August 1, 2018: Cell Adhesion & Migration
Hiwa O Ahmed, Sarmad H Arif, Sabah Abid Abdulhakim, Aram Kakarash, Mohammad Amin Ali Omer, Aree Majid Nuri, Hallo H Omer, Hardi Kareem Jalal, Shahen H Omer, Nashadin Aziz Muhammad
BACKGROUND: The increasing incidence of morbid obesity suggests that the quantity of bariatric surgical procedures will continue to multiply each year, many patients who have experienced massive weight loss are left with the dissatisfying consequences of loose and redundant skin, resulting in contour irregularities, an aesthetic and functional problem, and profound dissatisfaction with appearance, residual body image dissatisfaction, There is a subsequent increase in the number of patients seeking additional corrective procedures including abdominoplasty which considered as one of the most popular body-contouring procedures...
August 2018: International Journal of Surgery
Qian Peng, Wen-Li Xie, Jing-Yi Chen, Tao Jiang, Guo-Quan Zhang, Zhong-Wei Xu, Jin-Ning Zhang, Li Zhang
To prepare the asiaticoside nanoemulsions (ASI-NEs) and asiaticoside nanoemulsions-based gels (ASI-NBGs), compare them with the commercial cream of asiaticoside (ASI-C) in terms of transdermal characteristics, and investigate the transdermal mechanism of ASI-NEs and ASI-NBGs. Their transdermal characteristics were studied by using Franz diffusion cells. The effect of topical ASI-NEs and ASI-NBGs on ultrastructure of rabbit skin was evaluated by using HE staining method. The localization and the permeation pathway of asiaticoside were visually investigated by using laser scanning confocal microscope (CLSM)...
May 2018: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
Qing-Qing Fang, Xiao-Feng Wang, Wan-Yi Zhao, Chun-Ye Chen, Min-Xia Zhang, Bang-Hui Shi, Li-Yun Zhang, Wei-Qiang Tan
Angiotensin-converting enzyme (ACE) has been found in the pathogenesis of various fibrosis diseases, and ACE inhibitor (ACEI) may affect wound healing and cutaneous fibrosis. However, there is no scientific evidence as to where the ACE is produced during scar formation. Whether it is from the cutaneous tissue or the bone marrow, or both remains unknown. In this study, we investigated the source of ACE using bone marrow transplantation in genetically modified mice, analyzed the inflammatory milieu and some growth factors in the middle of the wound healing period (4 d after the wound was induced)...
September 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
Norbert Kiss, Dóra Haluszka, Kende Lőrincz, Enikő Kuroli, Judit Hársing, Balázs Mayer, Sarolta Kárpáti, György Fekete, Róbert Szipőcs, Norbert Wikonkál, Márta Medvecz
Ehlers-Danlos syndrome (EDS) is the name for a heterogenous group of rare genetic connective tissue disorders with an overall incidence of 1 in 5000. The histological characteristics of EDS have been previously described in detail in the late 1970s and early 1980s. Since that time, the classification of EDS has undergone significant changes, yet the description of the histological features of collagen morphology in different EDS subtypes has endured the test of time. Nonlinear microscopy techniques can be utilized for non-invasive in vivo label-free imaging of the skin...
July 2018: Archives of Dermatological Research
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