Anna P Ralph, Govert Waramori, Gysje J Pontororing, Enny Kenangalem, Andri Wiguna, Emiliana Tjitra, Sandjaja, Dina B Lolong, Tsin W Yeo, Mark D Chatfield, Retno K Soemanto, Ivan Bastian, Richard Lumb, Graeme P Maguire, John Eisman, Ric N Price, Peter S Morris, Paul M Kelly, Nicholas M Anstey
BACKGROUND: Vitamin D (vitD) and L-arginine have important antimycobacterial effects in humans. Adjunctive therapy with these agents has the potential to improve outcomes in active tuberculosis (TB). METHODS: In a 4-arm randomised, double-blind, placebo-controlled factorial trial in adults with smear-positive pulmonary tuberculosis (PTB) in Timika, Indonesia, we tested the effect of oral adjunctive vitD 50,000 IU 4-weekly or matching placebo, and L-arginine 6.0 g daily or matching placebo, for 8 weeks, on proportions of participants with negative 4-week sputum culture, and on an 8-week clinical score (weight, FEV1, cough, sputum, haemoptysis)...
2013: PloS One