Noemi Pagliaricci, Riccardo Pettinari, Fabio Marchetti, Alessia Tombesi, Sara Pagliaricci, Massimiliano Cuccioloni, Agustín Galindo, Farzaneh Fadaei-Tirani, Mouna Hadiji, Paul J Dyson
Curcuminoids and their complexes continue to attract attention in medicinal chemistry, but little attention has been given to their metabolic derivatives. Here, the first examples of (arene)Ru(II) complexes with curcuminoid metabolites, tetrahydrocurcumin (THcurcH), and tetrahydrobisdesmethoxycurcumin (THbdcurcH) were prepared and characterized. The neutral complexes [Ru(arene)(THcurc)Cl] and [Ru(arene)(THbdcurc)Cl] (arene = cymene, benzene, or hexamethylbenzene) were characterized by NMR spectroscopy and ESI mass spectrometry, and the crystal structures of the three complexes were determined by X-ray diffraction analysis...
April 18, 2024: Inorganic Chemistry