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https://www.readbyqxmd.com/read/30336275/vitamin-d-effects-on-sphingosine-1-phosphate-signaling-and-metabolism-in-monocytes-from-type-2-diabetes-patients-and-controls
#1
Nojan Nejatian, Sandra Trautmann, Dominique Thomas, Josef Pfeilschifter, Klaus Badenhoop, Alexander Koch, Marissa Penna-Martinez
Elevated sphingosine 1-phopshate (S1P) concentration was observed in type 2 diabetes mellitus (T2D). On the other side, 1α,25-dihydroxyvitamin D3 (1,25(OH)2 D3 ) can influence the formation of sphingosine 1-phopshate (S1P) and the expression of S1P receptors, which are known to be involved in T2D. In order to evaluate mechanisms for the antiinflammatory potential of 1,25(OH)2 D3 , we investigated whether 1,25(OH)2 D3 alters S1P signaling and metabolism in human CD14+ monocytes. Primary monocytes isolated from healthy controls (HC) and T2D patients were treated for 24 h with 10 nM 1,25(OH)2 D3 in the absence or presence of 500 IU/ml interleukin-(IL)-1β...
October 15, 2018: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/30336203/preparation-and-protective-effects-of-1-8-cineole-loaded-self-microemulsifying-drug-delivery-system-on-lipopolysaccharide-induced-endothelial-injury-in-mice
#2
Feng Jiang, GuoPing Wu, Wanrong Li, Jiajia Yang, Junli Yan, Yi Wang, Wenli Yao, Xue Zhou, Zhiyong He, Linjing Wu, Chaoda Xiao, Ting Xiao, Min Zhang, Xiangchun Shen, Ling Tao
An optimised 1,8-cineole-loaded self-microemulsifying drug delivery system (CIN-SMEDDS) with a mean droplet size, polydispersity index, mean zeta potential and encapsulation efficiency of 38.14 ± 1.47 nm, 0.208 ± 0.036, -9.312 ± 1.764 mV and 95.35% ± 1.13%, respectively, successfully ameliorated the lipopolysaccharide (LPS)-induced endothelial injury in mice. Acute toxicity assay in mice through the oral administration of CIN-SMEDDS showed that the median lethal dose of CIN-SMEDDS was 2998...
October 15, 2018: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/30335723/hip-and-knee-kinetics-during-a-back-squat-and-deadlift
#3
Kevin H Choe, Jared W Coburn, Pablo B Costa, Derek N Pamukoff
Choe, KH, Coburn, JW, Costa, PB, and Pamukoff, DN. Hip and knee kinetics during a back-squat and deadlift. J Strength Cond Res XX(X): 000-000, 2018-The back-squat and deadlift are performed to improve hip and knee extensor function. The purpose of this study was to compare lower extremity joint kinetics (peak net joint moments [NJMs] and positive joint work [PJW]) between the back-squat and deadlift. Twenty-eight resistance-trained subjects (17 men: 23.7 ± 4.3 years, 1.76 ± 0.09 m, 78.11 ± 10.91 kg; 11 women: 23...
October 17, 2018: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/30335579/the-acute-and-chronic-effects-of-hot-water-immersion-on-inflammation-and-metabolism-in-sedentary-overweight-adults
#4
Sven P Hoekstra, Nicolette C Bishop, Steve H Faulkner, Stephen J Bailey, Christof Andreas Leicht
Regular exercise-induced acute inflammatory responses are suggested to improve the inflammatory profile and insulin sensitivity. As body temperature elevations partly mediate this response, passive heating might be a viable tool to improve the inflammatory profile. This study investigated the acute, and chronic effects of hot water immersion on inflammatory and metabolic markers. Ten sedentary, overweight males (BMI: 31.0±4.2 kg/m2 ) were immersed in water set at 39°C for 1 h (HWI) or rested for 1 h at ambient temperature (AMB)...
October 18, 2018: Journal of Applied Physiology
https://www.readbyqxmd.com/read/30334030/surface-oxygen-containing-defects-of-graphene-nanosheets-with-tunable-nonlinear-optical-absorption-and-refraction
#5
Baohua Zhu, Fangfang Wang, Peng Li, Chong Wang, Yuzong Gu
Surface oxygen-containing defects of graphene nanosheets (G NSs) are important for the nonlinear optical (NLO) properties in optoelectric devices. G NSs with different surface oxygen-containing defects are successfully tuned by a chemical reduction process, and are characterized by several experimental measurements of morphology and structure and by spectroscopy. Their NLO properties are measured with the Z-scan technique and the NLO transmission method using a 30 picosecond single-pulse laser source at 532 nm wavelength...
October 18, 2018: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/30332791/enhancement-of-the-performance-and-data-processing-rate-of-an-optical-frequency-domain-reflectometer-distributed-sensing-system-using-a-limited-swept-wavelength-range
#6
Kunpeng Feng, Jiwen Cui, Yihua Jin, Xun Sun, Dong Jiang, Hong Dang, Yizhao Niu, Jiubin Tan
A novel optical frequency domain reflectometer (OFDR) processing algorithm is proposed to enhance the measurable range and data processing rate using a narrow swept spectrum range and reducing the time consuming of the process distributed sensing results. To reduce the swept wavelength range and simultaneously enhance strain measurable range, the local similarity characteristics of Rayleigh scattering fingerprint spectrum is discovered and a new similarity evaluation function based on least-square method is built to improve the data processing rate and sensing performance...
October 16, 2018: Sensors
https://www.readbyqxmd.com/read/30329129/comparison-of-chlorantraniliprole-and-flubendiamide-activity-towards-wild-type-and-malignant-hyperthermia-susceptible-ryanodine-receptors-and-heat-stress-intolerance
#7
Kim M Truong, Isaac N Pessah
Chlorantraniliprole (CP) and flubendiamide (FD) are widely used in agriculture globally to control lepidopteran pests. Both insecticides target ryanodine receptors (RyRs) and promote Ca2+ leak from sarcoplasmic reticulum (SR) within insect skeletal muscle yet are purportedly devoid of activity towards mammalian RyR1 and muscle. RyRs are ion channels that regulate intracellular Ca2+ release from SR during physiological excitation-contraction coupling. Mutations in RYR1 genes confer malignant hyperthermia susceptibility (MHS), a potentially lethal pharmacogenetic disorder in humans and animals...
October 17, 2018: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/30328905/influence-of-low-level-laser-irradiation-on-osteocalcin-protein-and-gene-expression-in-bone-tissue1
#8
Fernando Russo Costa do Bomfim, Valeria Regina Gonzalez Sella, Ronaldo Luís Thomasini, Helio Plapler
PURPOSE: To evaluate osteocalcin gene and protein expression in vitro and in an in vivo model of ostectomy. METHODS: Twenty Wistar rats were assigned into two groups A (n=10, laser) and B (n=10, control). Ostectomy was performed in the femur diaphysis; the twenty fragments removed, composed in vitro groups named as in vivo (A and B) and cultivated in CO2 atmosphere for thirteen days. Low-level laser irradiation was performed in groups A (in vivo and in vitro) by an GaAlAs device (λ=808 nm, dose of 2J/cm2, power of 200mW, power density of 0...
September 2018: Acta Cirúrgica Brasileira
https://www.readbyqxmd.com/read/30328526/modulation-of-exercise-induced-muscular-damage-and-hyperalgesia-by-different-630-nm-doses-of-light-emitting-diode-therapy-ledt-in-rats
#9
Alan B Vasconcelos, Fernando K Nampo, Júlio C Molina, Miriam B Silva, Alan S Oliveira, Tarlyson R de Angelis, Amanda L Hasuda, Enilton A Camargo, Solange P Ramos
We compared the acute effects of different doses of 630 nm light-emitting diode therapy (LEDT) on skeletal muscle inflammation and hyperalgesia in rats submitted to exercise-induced muscle damage (EIMD). Wistar rats were divided into five experimental groups (n = 5-8/group): sedentary control (CON); exercise + passive recovery (PR); and exercise + LEDT (1.2 J/cm2 , 1.8 J; 4.2 J/cm2 , 6.3 J; 10.0 J/cm2 , 15 J). After 100 min of swimming, the rats in the LEDT groups were exposed to phototherapy on the triceps surae muscle...
October 17, 2018: Lasers in Medical Science
https://www.readbyqxmd.com/read/30328447/experimental-determination-of-the-diameter-dependent-wettability-of-carbon-nanotubes-as-studied-using-atomic-force-microscopy
#10
Konan Imadate, Kaori Hirahara
The wettability of individual carbon nanotubes (CNTs) with <20 nm diameter was experimentally evaluated on the basis of the Wilhelmy method via atomic force microscopy to visualize the effect of the nanometer-scale curvature of a solid surface on the solid-liquid and solid-vapor interface tensions. The experimental results showed the deviation of force owing to wetting for diameters <10 nm. In particular, for nanotubes with <4.5 nm diameter, the wettability tended to differ from its previously predicted behavior...
October 17, 2018: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/30327806/bactericidal-effects-of-hematoporphyrin-monomethyl-ether-mediated-blue-light-photodynamic-therapy-against-staphylococcus-aureus
#11
Wei Ma, Tao Wang, Lixin Zang, Zhinan Jiang, Zhiguo Zhang, Liangjia Bi, Wenwu Cao
The implementation of photodynamic therapy (PDT) usually uses red light as the excitation source to obtain a deeper penetration depth. However, for some superficial infectious diseases, using red-light PDT may damage the normal tissues underneath. If we choose a shorter wavelength light, then the effect of PDT can be limited to the superficial region. This study assessed the effect of blue-light PDT against Staphylococcus aureus. The absorption of hematoporphyrin monomethyl ether (HMME) by S. aureus was investigated using fluorescence spectroscopy...
October 17, 2018: Photochemical & Photobiological Sciences
https://www.readbyqxmd.com/read/30327585/high-density-%C3%AE-led-based-optical-cochlear-implant-with-improved-thermomechanical-behavior
#12
Eric Klein, Christian Gossler, Oliver Paul, Patrick Ruther
This study reports the realization of an optical cochlear implant (oCI) with optimized thermomechanical properties for optogenetic experiments. The oCI probe comprises 144 miniaturized light-emitting diodes (μLEDs) distributed along a bendable, 1.5-cm-long, 350-μm-wide and 26-μm-thick probe shaft, individually controlled via a n × p matrix interconnection. In contrast to our earlier approach based on polyimide (PI) and epoxy resin with different thermal expansion coefficients, the μLEDs and interconnecting wires are now embedded into a triple-layer stack of a single, biocompatible, and highly transparent epoxy material...
2018: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/30327064/investigation-of-hydrogen-production-from-alkaline-sulfide-solution-with-nanosized-cds-zns-pds-photocatalyst-of-various-compositions
#13
Lajos Fodor, Bence Solymosi, Ottó Horváth
Hydrogen sulfide is highly toxic to humans and harmful to the environment. On the other hand, H₂S is produced in large quantities in some industrial processes like the refinery of crude oil and the sweetening of natural gas. Nowadays, H₂S is usually burned to sulfur and water in the Claussprocess wasting the energy of hydrogen stored in H₂S. Progress in the area of photocatalysis results in considerable development of the heterogeneous photocatalytic conversion of hydrogen sulfide into hydrogen gas. In this work, photocatalytic hydrogen production from alkaline sulfide solutions was investigated, utilizing various ZnS/CdS composites modified with PdS as cocatalyst...
January 1, 2019: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/30327018/fabrication-and-properties-of-electrospun-magnetoelectric-graphene-fe%C3%A2-o%C3%A2-poly-lactic-co-glycolic-acid-short-nanofibers
#14
Ping Li, Yao Xi, Kun Li, Bing Qi, Fengnian Zhu, Yubo Fan
When used in tissue engineering, polymer nanofibers with magnetic and electrical functionality could promote the growth of tissues and cells by applying magnetic and electric stimulation. Short nanofibers with these properties, which have a high specific surface area and can be arranged through magnetic induction, have potential applications in the fields of materials and biomedical engineering. In this study, poly(lactic-co-glycolic acid) (PLGA) nanofibers with nano-Fe₃O₄ particles were subjected to electrostatic spinning to obtain superparamagnetic Fe₃O₄/PLGA nanofibers...
January 1, 2019: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/30327016/a-facile-green-approach-for-synthesis-of-selenium-nanowires-with-visible-light-photocatalytic-properties
#15
Ze-Min Xia, Ya-Ning Liu, Zi Huang, Li-Zhao Qin, Hua Lin, Qing Li
In this work, high purity trigonal selenium (t-Se) nanowires were synthesized through a simple one-step solvothermal process at 50 °C. Sodium formaldehyde sulfoxylate (SFS) was used as a reducing agent. To our knowledge, this is the first time that SFS was used as the reducing agent for synthesis of Se nanostructures. In this method, Se nanowires were obtained at lower temperature, shorter period of reaction time and without using complex equipment. The experimental parameters, such as reaction duration, temperature and amount of surfactant, were investigated...
January 1, 2019: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/30327013/development-of-microarc-oxidation-sputter-ceo%C3%A2-duplex-ceramic-anti-corrosion-coating-for-az31b-mg-alloy
#16
Lingyi Yin, Jun Su, Lilu Qin, Niu Ma, Jiamu Huang
A duplex CeO₂/MAO coating was deposited on AZ31B magnesium alloy through microarc oxidation and reactive radio frequency magnetron sputtering. The microstructure and chemical composition of the proposed coating were investigated through scanning electron microscopy, X-ray diffraction, and X-ray photoelectron spectroscopy. The CeO₂/MAO coating was approximately 580 nm in thickness and showed fewer micropores and defects than those the MAO coating presented. The properties of corrosion resistance were assessed using the polarization test, electrochemical impedance spectroscopy, and the neutral salt spray test...
January 1, 2019: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/30326660/interplay-between-endoplasmic-reticular-stress-and-survivin-in-colonic-epithelial-cells
#17
Rohit Gundamaraju, Ravichandra Vemuri, Wai Chin Chong, Stephen Myers, Shaghayegh Norouzi, Madhur D Shastri, Rajaraman Eri
Sustained endoplasmic reticular stress (ERS) is implicated in aggressive metastasis of cancer cells and increased tumor cell proliferation. Cancer cells activate the unfolded protein response (UPR), which aids in cellular survival and adaptation to harsh conditions. Inhibition of apoptosis, in contrast, is a mechanism adopted by cancer cells with the help of the inhibitor of an apoptosis (IAP) class of proteins such as Survivin to evade cell death and gain a proliferative advantage. In this study, we aimed to reveal the interrelation between ERS and Survivin...
October 15, 2018: Cells
https://www.readbyqxmd.com/read/30326557/plasmonic-sensing-characteristics-of-gold-nanorods-with-large-aspect-ratios
#18
Chao Zhuang, Yifan Xu, Ningsheng Xu, Jinxiu Wen, Huanjun Chen, Shaozhi Deng
Plasmonic gold nanorods play important roles in nowadays state-of-the-art plasmonic sensing techniques. Most of the previous studies and applications focused on gold nanorods with relatively small aspect ratios, where the plasmon wavelengths are smaller than 900 nm. Gold nanorods with large aspect ratios are predicted to exhibit high refractive-index sensitivity (Langmir 2008, 24, 5233⁻5237), which therefore should be promising for the development of high-performance plasmonic chemical- and bio-sensors. In this study, we developed gold nanorods with aspect ratios over 7...
October 15, 2018: Sensors
https://www.readbyqxmd.com/read/30325459/does-lipidomic-serum-analysis-support-the-assessment-of-digestive-efficiency-in-chickens
#19
Stéphane Beauclercq, Antoine Lefèvre, Lydie Nadal-Desbarats, Karine Germain, Christophe Praud, Patrick Emond, Elisabeth Le Bihan-Duval, Sandrine Mignon-Grasteau
The increasing cost of conventional feedstuffs used in poultry diets has bolstered interest in genetic selection for digestive efficiency (DE) to improve the adaptation of the birds to various alternative feedstuffs. However, DE measurement through AMEn is time-consuming and constraining. To simplify selection for DE, the potential of serum composition to predict AMEn was evaluated based on 40 birds from two broiler lines (D+ and D-) divergently selected on the fecal AMEn of a difficult-to-digest wheat-based diet...
October 16, 2018: Poultry Science
https://www.readbyqxmd.com/read/30325375/light-scattering-detection-within-the-difficult-size-range-of-protein-particle-measurement-using-flow-cytometry
#20
Zhishang Hu, Chen Ye, Wei Mi, Yun Zhao, Can Quan, William W Li, Hongmei Li, Haiying Hang
The phenomenon of protein aggregation is a prominent challenge that impacts biopharmaceutical development at every stage. It may have a number of deleterious effects on protein drugs, including the loss of efficacy, induction of immunogenicity, altered pharmacokinetics and reduced shelf life. At present, multiple methods are available for counting and sizing particles over a broad range of sizes. However, there remains a conundrum in the measurement of particles in the submicrometer range, from 100 nm to 2 μm...
October 16, 2018: Nanoscale
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