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Alan Cervantes Farrell, Xiao Meng, Dingkun Ren, Hyunseok Kim, Pradeep Senanayake, Nick Y Hsieh, Zixuan Rong, Ting-Yuan Chang, Khalifa Mohammad Azizur-Rahman, Diana L Huffaker
Single photon detection at near-infrared (NIR) wavelengths is critical for light detection and ranging (LiDAR) systems used in imaging technologies such as autonomous vehicle trackers and atmospheric remote sensing. Portable, high-performance LiDAR relies on silicon-based single-photon avalanche diodes (SPADs) due to their extremely low dark count rate (DCR) and afterpulsing probability, but their operation wavelengths are typically limited up to 905 nm. Although InGaAs-InP SPADs offer an alternative platform to extend the operation wavelengths to eye-safe ranges, their high DCR and afterpulsing severely limit their commercial applications...
December 5, 2018: Nano Letters
Karin Cristina da Silva Modena, Adriana Maria Calvo, Carla Renata Sipert, Thiago José Dionísio, Maria Fidela de Lima Navarro, Maria Teresa Atta, Carlos Ferreira Santos
This study evaluated in vitro cell viability and metabolism, nitric oxide release and production of chemokines by cultured human dental pulp fibroblasts (DPF) under contact with HEMA and Single Bond. Cultures of DPF were established by means of an explant technique. Once plated, cells were kept under contact with increasing concentrations of HEMA (10, 100 and 1000 nM) or Single Bond (SB) [10-fold serially diluted in culture medium (10-4, 10-3 and 10-2 v/v)] and also with polymerized SB components. Cytotoxicity was assessed by Trypan Blue exclusion method and MTT [3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] assay...
September 2018: Brazilian Dental Journal
Li Wang, Qingrui Chang, Jing Yang, Xiaohua Zhang, Fenling Li
The performance of three machine learning methods (support vector regression, random forests and artificial neural network) for estimating the LAI of paddy rice was evaluated in this study. Traditional univariate regression models involving narrowband NDVI with optimized band combinations as well as linear multivariate calibration partial least squares regression models were also evaluated for comparison. A four year field-collected dataset was used to test the robustness of LAI estimation models against temporal variation...
2018: PloS One
Geon-Hee Nam, Kyounghwan Kim, Dae Sung Chung
Here we introduce a junction engineering approach to realize a high performance non-power-driven organic photodiode. To overcome the external power source dependency of conventional photodiodes, in this work, we try not only to implement an inherently large built-in-potential of the junction but also to utilize an inherently low charge carrier concentration of the semiconductor. The strategically designed ITO/plasma-treated ZnO/poly[2-methoxy-5-(2'-ethylhexyloxy)-p-phenylene vinylene] (MEH-PPV)/MoO3 /Ag geometry showed near-ideal Schottky junction properties with a high zero-bias built-in potential of 0...
February 1, 2019: Nanotechnology
Ferdinand F E Kohle, Joshua A Hinckley, Songying Li, Nikhil Dhawan, William P Katt, Jacob A Erstling, Ulrike Werner-Zwanziger, Josef Zwanziger, Richard A Cerione, Ulrich B Wiesner
In quantum materials, macroscopic behavior is governed in nontrivial ways by quantum phenomena. This is usually achieved by exquisite control over atomic positions in crystalline solids. Here, it is demonstrated that the use of disordered glassy materials provides unique opportunities to tailor quantum material properties. By borrowing ideas from single-molecule spectroscopy, single delocalized π-electron dye systems are isolated in relatively rigid ultrasmall (<10 nm diameter) amorphous silica nanoparticles...
December 5, 2018: Advanced Materials
Wei Zhou, Jingzhe Chen, Heng Gao, Tao Hu, Shuangchen Ruan, Alessandro Stroppa, Wei Ren
Recently, an emergent layered material Td -WTe2 was explored for its novel electron-hole overlapping band structure and anisotropic inplane crystal structure. Here, the photoresponse of mechanically exfoliated WTe2 flakes is investigated. A large anomalous current decrease for visible (514.5 nm), and mid- and far-infrared (3.8 and 10.6 µm) laser irradiation is observed, which can be attributed to light-induced surface bandgap opening from the first-principles calculations. The photocurrent and responsivity can be as large as 40 µA and 250 A W-1 for a 3...
December 5, 2018: Advanced Materials
Arkadiusz Jarota, Ewa Pastorczak, Walid Tawfik, Bing Xue, Rafał Kania, Halina Abramczyk, Takayoshi Kobayashi
A diarylethene derivative, 1,2-bis(2,4-dimethyl-5-phenyl-3-thienyl)perfluorocyclopentene (DMP), is a photoswitch molecule utilizing a reversible aromatic ring-opening reaction. The quantum yield of the ring-opening reaction is however remarkably low. We investigate the origin of this behaviour by means of ultrafast transient absorption spectroscopy utilizing sub-10 fs pulses, which is an invaluable tool for simultaneously studying both the electronic and the vibrational molecular dynamics. Namely, a noncollinear optical parametric amplifier (NOPA) generating sub-10 fs pulses in the spectral range 605-750 nm is employed...
December 5, 2018: Physical Chemistry Chemical Physics: PCCP
Mostafa Zamani, Amin Shirinzadeh, Mozhgan Aghajanzadeh, Sina Andalib, Hossein Danafar
PURPOSE: In this study, methoxy poly (ethylene glycol) -poly (ε-caprolactone) (mPEG-PCL) di block copolymers were synthesized. The purpose of this work is to investigate the in vivo anti-inflammatory effects of simvastatin-loaded micelles. METHODS: The structure of synthesized copolymers were characterized by using HNMR, FTIR and GPC techniques. Simvastatin was encapsulated in micelles through a single-step nano-precipitation method, leading to formation of simvastatin-loaded mPEG-PCL (simvastatin-mPEG-PCL) micelles...
December 5, 2018: Pharmaceutical Development and Technology
Selva Kumar R, S K Ashok Kumar, Kari Vijayakrishna, Akella Sivaramakrishna, C V S Brahmmananda Rao, N Sivaraman, Suban K Sahoo
In this paper, a new Th4+ ion-selective chromogenic sensor (L) was developed by reacting 1,10-phenanthroline-2,9-dicarbohydrazide with 2-hydroxy naphthaldehyde. The sensing ability of L toward Th4+ was investigated in solution and paper strips loaded with L using spectrophotometric and colorimetric methods. The selective interaction of L was examined with various f-metal ions and other selected metal ions from s-block and d-block elements. Results show that by the colorimetric method in solution-phase dimethyl sulfoxide/H2 O (7:3, v/v) and paper strip methods, the naked-eye detectable color change of L occurred from colorless solution to yellow-orange and pale yellow colour upon interacting with Th4+ and Al3+ , respectively, whereas other metal ions did not interfere...
December 5, 2018: Inorganic Chemistry
D I Ellis, H Muhamadali, Y Xu, R Eccles, I Goodall, R Goodacre
The spirits drinks industry is of significant global economic importance and a major employer worldwide, and the ability to ensure product authenticity and maintain consumer confidence in these high-value products is absolutely essential. Spirit drinks counterfeiting is a worldwide problem, with counterfeiting and adulteration of spirit drinks taking many forms, such as substitution, stretching with lower-grade products, or creation of counterfeits with industrial, surrogate, or locally produced alcohols. Methanol for example, which has been used as a substitute alcohol for ethanol, has a high toxicity in humans...
December 5, 2018: Analyst
Bin Wang, Cheng Tang, Hao-Fan Wang, Xiao Chen, Rui Cao, Qiang Zhang
A cost-effective and highly efficient oxygen evolution reaction (OER) electrocatalyst will be significant for the future energy scenario. The emergence of the core-shell heterostructure has invoked new feasibilities to inspire the full potential of non-precious-metal candidates. The shells always have a large thickness, affording robust mechanical properties under harsh reaction conditions, which limits the full exposure of active sites with highly intrinsic reactivity and extrinsic physicochemical characters for optimal performance...
December 5, 2018: Advanced Materials
Dyab A Al-Eryani, Waqas Ahmad, Gharam I Mohammad, Faten M Ali Zainy, Hassan Alwael, Saleh O Bahaffi, Mohammad S El-Shahawi
A simple extractive spectrofluorimetric strategy for trace determination of mercury(II) ions in water employing procaine hydrochloride (PQ+ ) as an ion pairing fluorescent tagging reagent has been established. The method was based upon the extraction of PQ+ from aqueous iodide media onto dichloromethane as a ternary complex ion associate [(PQ+ )2 .(HgI4 )2- ] at pH 9.0-10.0 with subsequent quenching at λex/em  = 268/333 nm. The developed strategy exhibited a linear range 20-140 nM with a lower limit of detection (LOD) 6...
December 4, 2018: Journal of Fluorescence
Ding-Yi Fu, Ya-Rong Xue, Yongqing Guo, Zhiyu Qu, Hong-Wei Li, Hui Wu, Yuqing Wu
Glutathione S-transferase (GST) is distributed widely in tissues and has been proven to be vital in the body. For example, it catalyzes reduced glutathione (GSH) to a variety of electrophilic substances and thus protects cells against many toxic chemicals. Therefore, GST-related investigations have always been significant for medical and/or life sciences. In the present study, a new material of gold nanoclusters (Au-NCs) protected by GST, Au-NCs@GST, was fabricated via an improved one-step heating method. The products were fully characterized by X-ray photoelectron spectroscopy (XPS), transmission electron microscopy (TEM), matrix-assisted laser desorption/ionization time of flight mass spectrometry (MALDI-TOF MS), and Fourier transform infrared (FT-IR) and circular dichroism (CD) spectra...
December 5, 2018: Nanoscale
Anna Lagunas, Alejandra Guerra-Castellano, Alba Nin-Hill, Irene Díaz-Moreno, Miguel A De la Rosa, Josep Samitier, Carme Rovira, Pau Gorostiza
Despite the importance of electron transfer between redox proteins in photosynthesis and respiration, the inter-protein electron transfer rate between redox partner proteins has never been measured as a function of their separation in aqueous solution. Here, we use electrochemical tunneling spectroscopy to show that the current between two protein partners decays along more than 10 nm in the solution. Molecular dynamics simulations reveal a reduced ionic density and extended electric field in the volume confined between the proteins...
December 4, 2018: Nature Communications
Maija-Liisa Mattinen, Guillaume Riviere, Alexander Henn, Robertus Wahyu N Nugroho, Timo Leskinen, Outi Nivala, Juan José Valle-Delgado, Mauri A Kostiainen, Monika Österberg
Lignin has interesting functionalities to be exploited in adhesives for medicine, foods and textiles. Nanoparticles (NPs) < 100 nm coated with poly (L -lysine), PL and poly(L -glutamic acid) PGA were prepared from the laccase treated lignin to coat nanocellulose fibrils (CNF) with heat. NPs ca. 300 nm were prepared, β-casein coated and cross-linked with transglutaminase (Tgase) to agglutinate chamois. Size exclusion chromatography (SEC) and Fourier-transform infrared (FTIR) spectroscopy were used to characterize polymerized lignin, while zeta potential and dynamic light scattering (DLS) to ensure coating of colloidal lignin particles (CLPs)...
December 3, 2018: Nanomaterials
Xin Xue, Gang Bao, Hai-Qing Zhang, Ning-Yi Zhao, Yuan Sun, Yue Zhang, Xiao-Long Wang
: The judicious application of ligand or binding efficiency (LE) metrics, which quantify the molecular properties required to obtain binding affinity for a drug target, is gaining traction in the selection and optimization of fragments, hits and leads. Here we report for the first time the use of LE based metric, fit quality (FQ), in virtual screening (VS) of MDM2/p53 protein-protein interaction inhibitors (PPIIs). Firstly, a Receptor-Ligand pharmacophore model was constructed on multiple MDM2/ligand complex structures to screen the library...
December 1, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Daniela Chirio, Elena Peira, Simona Sapino, Chiara Dianzani, Alessandro Barge, Elisabetta Muntoni, Silvia Morel, Marina Gallarate
Chitosan is an excipient which has been studied thoroughly in research works thanks to its positive characteristics such as muco-adhesiveness and ability to open epithelial-tight-junctions. In this article, lipophilic stearoyl chitosan (ST-CS) was synthetized in order to anchor this polymer to lipid nanoparticles and prepare ST-CS-coated nanoparticles (ST-CS-NP) using the microemulsion cold dilution technique. Curcumin (CURC) was used as model drug. CURC-ST-CS-NP were characterized by dimensional analysis, zeta potential, drug entrapment, drug release; tested in vitro on Human Umbilical Vein Endothelial Cell (HUVEC) cells to study its cytotoxicity and on human pancreatic cancer cells (PANC-1) to determine inhibition ability; tested in rats to determine CURC blood profiles and biodistribution...
November 30, 2018: International Journal of Molecular Sciences
Flávia A P de Morais, Renato S Gonçalves, Bruno H Vilsinski, Évelin L de Oliveira, Nicola L Rocha, Noboru Hioka, Wilker Caetano
Hypericin (Hyp) is a potential photosensitizer drug for Photodynamic Therapy (PDT). However, the high lipophilicity of Hyp prevents its preparation in water. To overcome the Hyp solubility problem, this study uses the liposomal vesicle of DPPC. Otherwise liposome is also one of the most employed artificial systems that mimetizes cell membranes. Our present focus is the interaction of Hyp into DPPC liposome as biomimetic system. We studied the loading, interaction, and localization of Hyp (2.8 μmol L-1 ) in DPPC (5...
November 28, 2018: Journal of Photochemistry and Photobiology. B, Biology
Vincenzo Ferrone, Roberto Cotellese, Annadomenica Cichella, Paolo Raimondi, Maura Carlucci, Paola Palumbo, Giuseppe Carlucci
A simple and rapid ultra high-performance liquid chromatographic (UHPLC) for the simultaneous determination of meropenem and ciprofloxacin in human plasma was developed and validate. All the analytes were separated in less than 5 min. A solid-phase extraction method was applied from samples preparation. Analytical separation was performed on a Poroshell SB C18 column (50 x 2.1 mm, 2.7 μm particle size) with PDA detection. Meropenem and ciprofloxacin were carried out at a wavelength 300 and 277 nm, respectively...
December 4, 2018: Biomedical Chromatography: BMC
Roopa NilamberLal Das, Sridevi Muruhan, Rajendra Prasad Nagarajan, Agilan Balupillai
The present study, we investigate the preventive role of naringin, a dietary flavonoid, against ultraviolet-B (UVB) radiation (280-320 nm) induced oxidative damage and inflammatory responses in mouse embryonic fibroblast cell lines (NIH-3T3). In this study, 20 mJ/cm 2 of UVB radiation induces cell cytotoxicity, reactive oxygen species (ROS) generation, DNA damage, and antioxidants depletion in NIH-3T3 cells. Treatment with naringin (60 µM) prior UVB exposure prevented the cell cytotoxicity, ROS generation, DNA damage, and antioxidants depletion in NIH-3T3 cells...
December 4, 2018: Journal of Biochemical and Molecular Toxicology
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