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https://www.readbyqxmd.com/read/30107140/evaluation-of-aib-and-peg-polymer-insect-kinin-analogs-on-mosquito-and-tick-gpcrs-identifies-potent-new-pest-management-tools-with-potentially-enhanced-biostability-and-bioavailability
#1
Caixing Xiong, Krzysztof Kaczmarek, Janusz Zabrocki, Patricia V Pietrantonio, Ronald J Nachman
Insect kinins modulate aspects of diuresis, digestion, development, and sugar taste perception in tarsi and labellar sensilla in mosquitoes. They are, however, subject to rapid biological degradation by endogenous invertebrate peptidases. A series of α-aminoisobutyric (Aib) acid-containing insect kinin analogs incorporating sequences native to the Aedes aegypti mosquito aedeskinins were evaluated on two recombinant kinin invertebrate receptors stably expressed in cell lines, discovering a number of highly potent and biostable insect kinin mimics...
August 11, 2018: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/30107124/photo-induced-enhanced-raman-from-lithium-niobate-on-insulator-template
#2
Rusul M Al-Shammari, Mohammad Amin Baghban, Nebras Alattar, Aoife A Gowen, Katia Gallo, James H Rice, Brian J Rodriguez
Photo-induced enhanced Raman spectroscopy from a lithium niobate on insulator (LNOI)-silver nanoparticle template is demonstrated both by irradiating the sample with 254 nm UV light before adding an analyte and before placing the sample in the Raman system (substrate irradiation) and by irradiating the sample in the Raman system after adding the molecule (sample irradiation). The photo-induced enhancement enables up to a ~ 7-fold increase of the surface enhanced Raman scattering signal strength of an analyte following substrate irradiation, whereas a ~ 3-fold enhancement above the surface enhanced signal is obtained for sample irradiation...
August 14, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/30106942/enhancement-of-the-lasing-efficiency-of-vitamin-b-2-in-a-highly-polar-organic-solvent-via-dna-lipid-complex
#3
Woohyun Jung, Byung Joo Kong, Seongjin Hong, Taeoh Kim, Kyunghwan Oh
We experimentally demonstrated a green liquid laser at the wavelength of 570 nm, utilizing the optical gain of vitamin B2 in a highly polar organic solvent, and proposed an efficient method to enhance its lasing efficiency by adding DNA-lipid complex (DNA-CTMA) in the solution. Optical properties of vitamin B2 in the hexafluoro-2-propanol solvents were investigated by adding various amounts of DNA-CTMA in terms of the UV-visible absorbance, the visible emission, and the fluorescence lifetime. A Fabry-Perot cavity was built to obtain the laser oscillation at 570 nm using a pulsed pump source at the wavelength of 450 nm, 5 ns pulse duration, and 10 Hz repetition rate...
August 15, 2018: Optics Letters
https://www.readbyqxmd.com/read/30106925/simultaneous-generation-of-high-power-ultrafast-1d-and-2d-airy-beams-and-their-frequency-doubling-characteristics
#4
Raghwinder S Grewal, Anirban Ghosh, G K Samanta
We report on a simple experimental scheme based on a pair of cylindrical lenses (convex and concave) of the same focal length and common optical elements, producing high power optical beams in 1D and/or 2D Airy intensity profiles with laser polarization as the control parameter. Using an ultrafast Yb-fiber laser at 1064 nm of average power of 5 W in a Gaussian spatial profile and pulse width of ∼180  fs, we have generated 1D and 2D Airy beams at an efficiency of 80% and 70%, respectively, and a pulse width of ∼188 and ∼190  fs, respectively...
August 15, 2018: Optics Letters
https://www.readbyqxmd.com/read/30106343/target-size-variation-in-microdosimetric-distributions-and-its-impact-on-the-linear-quadratic-parameterization-of-cell-survival
#5
Fernanda Villegas, Nina Tilly, Anders Ahnesjö
The linear-quadratic (LQ) parameterization of survival fraction [SF( D)] inherently assumes that all cells in a population receive the same dose ( D), albeit the distribution of specific energy z over the individual cells f( z, D) can be very wide. From these microdosimetric distributions, which are target size dependent, we estimate the size of the cellular sensitive volume by analyzing its influence on the LQ parameterization of cell survival. A Monte Carlo track structure code was used to simulate detailed tracks from a 60 Co source as well as proton and carbon ions of various energies...
August 14, 2018: Radiation Research
https://www.readbyqxmd.com/read/30106076/boosting-visible-light-photocatalytic-h-2-evolution-via-uio-66-nh-2-octahedrons-decorated-with-ultrasmall-nio-nanoparticles
#6
Cong-Cong Shen, Ya-Nan Liu, Xin Wang, Xiao-Xiang Fang, Zhi-Wei Zhao, Nan Jiang, Liu-Bo Ma, Xiao Zhou, Tuck-Yun Cheang, An-Wu Xu
Metal-organic framework (MOF)-based materials possess numerous attractive characteristics; however, the application of MOF-based photocatalysts in the area of visible-light photocatalytic H2 evolution is still in its infancy. Herein, we develop a series of novel UiO-66-NH2-based composites with embedded NiO nanoparticles via solvothermal treatment and subsequent calcination. Their characterizations demonstrate intimate lattice-level contacts between UiO-66-NH2 photocatalysts and NiO nanoparticles. By optimizing each component, even without noble metal loading, the U6N-NiO-2 sample (the weight ratio of NiO to U6N-NiO-2 is theoretically calculated to be ca...
August 14, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/30106005/self-powered-single-semiconductor-nanowire-photodetector
#7
Shaili Sett, Subhamita Sengupta, N Ganesh, K S Narayan, Arup Kumar Raychaudhuri
Self-powered photodetectors have been fabricated from a single Germanium nanowire (NW) in the metal-semiconductor-metal (MSM) device configuration. The self-powered devices show high photoresponse (Responsivity~ 10<sup>3</sup>-10<sup>5</sup>A/W) in the wavelength range 300-1100 nm. It has been established from I-V characteristics that there exists asymmetry in Schottky Barrier Height (SBH) at the two MS contacts. We have used simulation to establish that the asymmetric SBH at the metal contacts in a MSM device is a major cause for the "built-in" axial field that leads to separation of light generated electron-hole pair in the absence of an applied bias...
August 14, 2018: Nanotechnology
https://www.readbyqxmd.com/read/30105918/sodium-stibogluconate-loaded-nano-deformable-liposomes-for-topical-treatment-of-leishmaniasis-macrophage-as-a-target-cell
#8
M Junaid Dar, Fakhar Ud Din, Gul Majid Khan
Topical drug delivery against cutaneous leishmaniasis (CL) signifies an effective alternate for improving the availability and reducing the toxicity associated with the parenteral administration of conventional sodium stibogluconate (SSG) injection. The basic aim of the study was to develop nano-deformable liposomes (NDLs) for the dermal delivery of SSG against CL. NDLs were formulated by a modified thin film hydration method and optimized via Box-Behnken statistical design. The physicochemical properties of SSG-NDLs were established in terms of vesicle size (195...
November 2018: Drug Delivery
https://www.readbyqxmd.com/read/30105906/chemically-modified-hydrogel-filled-nanopores-a-tunable-platform-for-single-molecule-sensing
#9
Dana Al Sulaiman, Paolo Cadinu, Aleksandar P Ivanov, Joshua B Edel, Sylvain Ladame
Label-free, single-molecule sensing nanotechnologies represent ideal candidates for biomedical applications that rely on the detection of low copy number of biomolecules in small volumes of potentially complex biofluids. Among them, solid-state nanopores can be engineered that detect single molecules of charged analytes when they are electrically driven through the nanometer-sized aperture. Successfully applied to nucleic acid sensing, a fast transport in the range of 10-100 nucleotides per nanosecond often precludes the use of standard nanopores for the detection of the smallest fragments...
August 14, 2018: Nano Letters
https://www.readbyqxmd.com/read/30105543/simultaneous-voltammetric-detection-of-5-hydroxyindole-3-acetic-acid-and-5-hydroxytryptamine-using-a-glassy-carbon-electrode-modified-with-conducting-polymer-and-platinised-carbon-nanofibers
#10
Zina Fredj, MounirBen Ali, Baljit Singh, Eithne Dempsey
The authors describe a method for simultaneous voltammetric determination of 5-hydroxytryptamine (serotonin; 5-HT) and its metabolite 5-hydroxyindoleacetic acid (5-HIAA). A glassy carbon electrode was modified with poly(pyrrole-3-carboxylic acid) and with platinised carbon nanofibers to obtain a sensor that can quantify 5-HT and 5-HIAA with detection limits of 10 nM and 20 nM, respectively. The peak currents, best measured at voltages of 170 mV and 500 mV (vs. Ag/AgCl) for 5-HT and 5-HIAA, increase linearly in the 0...
August 13, 2018: Mikrochimica Acta
https://www.readbyqxmd.com/read/30105526/bioreducible-poly-amino-ethers-based-mtor-sirna-delivery-for-lung-cancer
#11
Nishant S Gandhi, Sudhakar Godeshala, Dana-Lynn T Koomoa-Lange, Bhavani Miryala, Kaushal Rege, Mahavir B Chougule
PURPOSE: Lung cancer is one of the leading causes of deaths in the United States, but currently available therapies for lung cancer are associated with reduced efficacy and adverse side effects. Small interfering RNA (siRNA) can knock down the expression of specific genes and result in therapeutic efficacy in lung cancer. Recently, mTOR siRNA has been shown to induce apoptosis in NSCLC cell lines but its use is limited due to poor stability in biological conditions. METHODS: In this study, we modified an aminoglyocisde-derived cationic poly (amino-ether) by introducing a thiol group using Traut's reagent to generate a bio-reducible modified-poly (amino-ether) (mPAE)...
August 13, 2018: Pharmaceutical Research
https://www.readbyqxmd.com/read/30105482/examination-of-the-cellular-mechanisms-of-leukocyte-elevation-by-10-6-%C3%AE-m-and-650-nm-laser-acupuncture-moxibustion
#12
Lanlan Liu, Ling Zhao, Ke Cheng, Haiping Deng, Menghu Guo, Jianzi Wei, Xueyong Shen
To investigate the cell cycle and cellular mechanisms of leukocyte elevation by laser acupuncture in rats with cyclophosphamide (CTX)-induced leukopenia. Sixty-six rats were randomized into six groups: normal, model control group, sham treatment group, 10.6 μm laser treatment group, 650 nm laser treatment group, and 10.6 μm-650 nm compound laser treatment group. Eleven rats were used in the normal group and 55 were models that were injected with cyclophosphamide to induce leukopenia. For the three laser treatment groups, 10...
July 22, 2018: Lasers in Medical Science
https://www.readbyqxmd.com/read/30105051/a-reduction-in-adam17-expression-is-involved-in-the-protective-effect-of-the-ppar-%C3%AE-activator-fenofibrate-on-pressure-overload-induced-cardiac-hypertrophy
#13
Si-Yu Zeng, Hui-Qin Lu, Qiu-Jiang Yan, Jian Zou
The peroxisome proliferator-activated receptor- α (PPAR- α ) agonist fenofibrate ameliorates cardiac hypertrophy; however, its mechanism of action has not been completely determined. Our previous study indicated that a disintegrin and metalloproteinase-17 (ADAM17) is required for angiotensin II-induced cardiac hypertrophy. This study aimed to determine whether ADAM17 is involved in the protective action of fenofibrate against cardiac hypertrophy. Abdominal artery constriction- (AAC-) induced hypertensive rats were used to observe the effects of fenofibrate on cardiac hypertrophy and ADAM17 expression...
2018: PPAR Research
https://www.readbyqxmd.com/read/30104970/structural-properties-of-synaptic-transmission-and-temporal-dynamics-at-excitatory-layer-5b-synapses-in-the-adult-rat-somatosensory-cortex
#14
Astrid Rollenhagen, Ora Ohana, Kurt Sätzler, Claus C Hilgetag, Dietmar Kuhl, Joachim H R Lübke
Cortical computations rely on functionally diverse and highly dynamic synapses. How their structural composition affects synaptic transmission and plasticity and whether they support functional diversity remains rather unclear. Here, synaptic boutons on layer 5B (L5B) pyramidal neurons in the adult rat barrel cortex were investigated. Simultaneous patch-clamp recordings from synaptically connected L5B pyramidal neurons revealed great heterogeneity in amplitudes, coefficients of variation (CVs), and failures (F%) of EPSPs...
2018: Frontiers in Synaptic Neuroscience
https://www.readbyqxmd.com/read/30104875/iridium-iii-complex-loaded-liposomes-as-a-drug-delivery-system-for-lung-cancer-through-mitochondrial-dysfunction
#15
Cancheng Liao, Danqiao Xu, Xiaohong Liu, Yuqi Fang, Jun Yi, Xiaofang Li, Bohong Guo
Background and aim: Iridium (Ir)-based complex is a potential antitumor ingredient, but its poor physicochemical properties such as hydrophobicity and low biocompatibility hamper further application. Liposome provides a potential delivery approach for improving the poor physicochemical property and reducing the side effects of antitumor drug. In this study, we aimed at incorporating Ir ([Ir(ppy)2 (BTCP)]PF6 ) into liposomes to enhance the biocompatibility and sustained release of Ir for intravenous administration and to elucidate the mechanism in A549 cells...
2018: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/30104461/synthesis-and-characterisation-of-liposomal-doxorubicin-with-loaded-gold-nanoparticles
#16
Ali Akbar Karimi Zarchi, Seyed Mohamad Amini, Ali Salimi, Sharmin Kharazi
Developing nanostructures for cancer treatment is growing significantly. Liposomal doxorubicin is a drug that is used in the clinic and represents a lot of benefits over doxorubicin. The development of multifunctional liposomes with different cancer treatment capability enables broader applications of doxorubicin chemotherapy. Many efforts were carried to prepare more effective liposomal formulation through loading gold nanoparticles (GNPs) in the formulation. Here, GNPs with an average size of 6 nm were loaded in liposomal formulation alongside doxorubicin...
September 2018: IET Nanobiotechnology
https://www.readbyqxmd.com/read/30104455/fabrication-of-cellulose-nanoparticles-through-electrospraying
#17
Nastaran Kadivar, Hossein Tavanai, Alireza Allafchian
This study reports the fabrication of cellulose nanoparticles through electrospraying the solution of cellulose in N,N -dimethylacetamide/lithium chloride solvent as well as investigating the effect of electrospraying conditions and molecular weight on the average size of electrosprayed nanoparticles. Electrospraying of cellulose was carried out with the following range for each factor, namely concentration = 1-3 wt%, voltage = 15-23 kV, nozzle-collector distance = 10-25 cm, and feed rate = 0...
September 2018: IET Nanobiotechnology
https://www.readbyqxmd.com/read/30103771/protocol-for-serum-exosomal-mirnas-analysis-in-prostate-cancer-patients-treated-with-radiotherapy
#18
Bijaya Malla, Daniel M Aebersold, Alan Dal Pra
BACKGROUND: Circulating exosomes from prostate cancer (PCa) patients undergoing radiotherapy are attractive candidate biomarkers for monitoring treatment response. Multiple workflows for isolation and content characterization of exosomes in biofluids have been attempted. We report a protocol to isolate and characterize exosomal miRNAs content and assess radiation-induced changes. METHODS: In this pilot study, we performed targeted exosomal miRNA profiling of 25 serum samples obtained from PCa patients with intermediate- and high-risk disease treated with curative radiotherapy (RT), and controls...
August 13, 2018: Journal of Translational Medicine
https://www.readbyqxmd.com/read/30103511/calcined-mussel-shell-powder-cmsp-via-modification-with-surfactants-application-for-antistatic-oil-removal
#19
Danyi Wei, Hailong Zhang, Lu Cai, Jian Guo, Yaning Wang, Lili Ji, Wendong Song
Biomass is known to efficiently adsorb pollutants from wastewater. In this paper, we demonstrated that a new antistatic oil-cleaning material can be prepared and assembled by using two surfactants, alkyl polyglucosides (APG) and dimethyl octadecyl hydroxy ethyl ammonium nitrate (SN), to modify calcined mussel shell powder (CMSP) through a two-step hydrotherm-assisted adsorption. The pore size and structure of CMSP was measured by BET and a contact angle meter was used to characterize the surface wetting ability...
August 11, 2018: Materials
https://www.readbyqxmd.com/read/30103294/steric-demand-and-rate-determining-step-for-photoenolization-of-di-ortho-substituted-acetophenone-derivatives
#20
Anushree Das, Suma S Thomas, August A Garofoli, Kevin A Chavez, Jeanette A Krause, Cornelia Bohne, Anna D Gudmundsdottir
Laser flash photolysis of ketone 1 in argon-saturated methanol yields triplet biradical 1BR (τ = 63 ns) that intersystem crosses to form photoenols Z-1P (λmax = 350 nm, τ ~ 10 μs) and E-1P (λmax = 350 nm, τ > 6 ms). The activation barrier for Z-1P re-forming ketone 1 through a 1,5-H shift was determined as 7.7 ± 0.3 kcal mol-1 . In contrast, for ketone 2, which has a less sterically hindered carbonyl moiety, laser flash photolysis in argon-saturated methanol revealed the formation of biradical 2BR (λmax = 330 nm, τ ~ 303 ns) that intersystem crosses to form photoenol E-2P (λmax = 350 nm, τ > 42 μs), but photoenol Z-2P was not detected...
August 13, 2018: Photochemistry and Photobiology
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