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JOURNAL ARTICLE
C H Li, X Lei, C X Zheng, Y Jin, B D Sui, S Q Ying
Objective: To explore the biological process of liver tissue-derived extracellular vesicle (LT-EV) in promoting osteogenic differentiation of mesenchymal stem cells and healing of jaw defects to provide a feasible treatment method for the clinical treatment of jaw bone defects. Methods: Enzymatic hydrolysis and differential centrifugation were used to extract LT-EV, scanning electron microscopy, Western blotting, and nanoparticle tracking analyzers were used to identify and characterize LT-EV, and further to explore the biological functions of LT-EV through proteomics and Kyoto Encyclopedia of Genes and Genomes...
April 18, 2024: Zhonghua Kou Qiang Yi Xue za Zhi, Zhonghua Kouqiang Yixue Zazhi, Chinese Journal of Stomatology
#22
JOURNAL ARTICLE
B D Sui, Y Jin
Mesenchymal stem cells, under spatiotemporal regulation of genes and microenvironment, are capable of spontaneously aggregating into dense regions, a phenomenon known as mesenchymal condensation. Mesenchymal condensation is an evolutionarily conserved developmental event that is critical in initiating morphogenesis of teeth and systemic organs. Mesenchymal stem cells hold the intrinsic ability to self-assemble in culture, and the generation of stem cell aggregates based on this property that mimics developmental mesenchymal condensation has become a potent and promising approach in regenerative medicine...
April 18, 2024: Zhonghua Kou Qiang Yi Xue za Zhi, Zhonghua Kouqiang Yixue Zazhi, Chinese Journal of Stomatology
#23
JOURNAL ARTICLE
Kassandra De Pao Mendonca, Caroline Rocher, Aurélie Dufour, Quentin Schenkelaars, Lars-Eric Heimbürger-Boavida, André le Bivic, Carole Borchiellini, Julien Issartel, Emmanuelle Renard
Mediterranean marine biota suffers from various anthropogenic threats. Among them, pollutants such as mercury (Hg) represent important environmental issues that are exacerbated by bioaccumulation and bioamplification along food webs via its organic form, monomethylmercury (MMHg). To date, very little is known regarding the impact of mercury on Porifera and the few available studies have been exclusively focused on Demospongiae. This work studies the effect of MMHgCl at different biological levels of Oscarella lobularis (Porifera, Homoscleromorpha)...
April 16, 2024: Chemosphere
#24
REVIEW
Léo Pio-Lopez, Michael Levin
Maintaining order at the tissue level is crucial throughout the lifespan, as failure can lead to cancer and an accumulation of molecular and cellular disorders. Perhaps, the most consistent and pervasive result of these failures is aging, which is characterized by the progressive loss of function and decline in the ability to maintain anatomical homeostasis and reproduce. This leads to organ malfunction, diseases, and ultimately death. The traditional understanding of aging is that it is caused by the accumulation of molecular and cellular damage...
April 16, 2024: Ageing Research Reviews
#25
JOURNAL ARTICLE
Mark E Fuller, Yuwei Zhao, Paul C Hedman, Paul G Koster van Groos, Anthony Soto, Francis Boodoo, Jord Yniguez, Erica R McKenzie
One of the primary technologies currently being deployed for the removal of per- and polyfluoroalkyl substances (PFAS) from water is ion exchange (IX). For regenerable IX resins, concentrated PFAS in the resulting spent brine and/or still bottoms requires further treatment. This research demonstrated that PFAS in spent brine and still bottoms can be effectively degraded sonochemically at 1000 kHz. Overall, PFAS degradation was negatively impacted by high total organic carbon (TOC) and residual methanol (MeOH) solvent (up to 50 g/kg; 5% w:w), but was enhanced by the high chloride...
April 16, 2024: Journal of Hazardous Materials
#26
JOURNAL ARTICLE
Zhaowei Li, Jianing Zhao, Yongjian Wang, Ao Yu
The detailed mechanism of transition metal-free-catalyzed monomethylation of 2-naphthyl acetonitrile ( 1a ) with CO2 in the presence of triazabicyclodecene (TBD) and BH3 NMe3 was investigated using density functional theory. The C-methylation process proved to generate formaldehyde followed by the formation of the product via an alcohol rather than a methoxyborane intermediate. During the reaction, CO2 is activated to form the TBD-CO 2 adduct and BH3 NMe3 is changed into TBD-BH 2 ( IM2 ) in the presence of TBD...
April 18, 2024: Journal of Organic Chemistry
#27
JOURNAL ARTICLE
Li Long, Xuechun Wang, Heyun Fu, Xiaolei Qu, Shourong Zheng, Zhaoyi Xu
Iron-based materials are effective for the reductive removal of the disinfection byproduct bromate in water, while the construction of highly stable and active Fe-based materials with wide pH adaptability remains greatly challenging. In this study, highly dispersed iron phosphide-decorated porous carbon (Fe2 P( x )@P( z )NC- y ) was prepared via the thermal hydrolysis of Fe@ZIF-8, followed by phosphorus doping (P-doping) and pyrolysis. The reduction performances of Fe2 P( x )@P( z )NC- y for bromate reduction were evaluated...
April 18, 2024: ACS Applied Materials & Interfaces
#28
JOURNAL ARTICLE
Julia Vettese, Julie Manon, Antoine Chretien, Robin Evrard, Lies Fievé, Thomas Schubert, Benoît G Lengelé, Catherine Behets, Olivier Cornu
Large bone defect regeneration remains a major challenge for orthopedic surgeons. Tissue engineering approaches are therefore emerging in order to overcome this limitation. However, these processes can alter some of essential native tissue properties such as intermolecular crosslinks of collagen triple helices, which are known for their essential role in tissue structure and function. We assessed the persistence of extracellular matrix (ECM) properties in human fascia lata (HFL) and periosteum (HP) after tissue engineering processes such as decellularization and sterilization...
2024: Frontiers in Bioengineering and Biotechnology
#29
REVIEW
Mari Murakami
Tissue-resident memory T cells (TRM ) serve as the frontline of host defense, playing a critical role in protection against invading pathogens. This emphasizes their role in providing rapid on-site immune responses across various organs. The physiological significance of TRM is not just confined to infection control; accumulating evidence has revealed that TRM also determine the pathology of diseases such as autoimmune disorders, inflammatory bowel disease, and cancer. Intensive studies on the origin, mechanisms of formation and maintenance, and physiological significance of TRM have elucidated the transcriptional and functional diversity of these cells, which are often affected by local cues associated with their presence...
April 17, 2024: Inflammation and Regeneration
#30
JOURNAL ARTICLE
Emma Lång, Anna Lång, Pernille Blicher, Torbjørn Rognes, Paul Gunnar Dommersnes, Stig Ove Bøe
The ability of epithelial monolayers to self-organize into a dynamic polarized state, where cells migrate in a uniform direction, is essential for tissue regeneration, development, and tumor progression. However, the mechanisms governing long-range polar ordering of motility direction in biological tissues remain unclear. Here, we investigate the self-organizing behavior of quiescent epithelial monolayers that transit to a dynamic state with long-range polar order upon growth factor exposure. We demonstrate that the heightened self-propelled activity of monolayer cells leads to formation of vortex-antivortex pairs that undergo sequential annihilation, ultimately driving the spread of long-range polar order throughout the system...
April 19, 2024: Science Advances
#31
JOURNAL ARTICLE
Ghinwa Barakat, Ghaith Assi, Hussein Khalil, Sami El Khatib
Diabetes Mellitus develops when the body becomes unable to fuel its cells with glucose, which results in the accumulation of sugar excess in the bloodstream. Because it has diverse pathophysiological impacts on the body, diabetes mellitus represents a significant issue of concern in an attempt to find suitable treatment modalities and medications for afflicted diabetic patients. Glucagon-like peptide 1 (GLP-1) plays a pivotal role in the incretin effect, emerging as a prospective treatment for diabetes mellitus and a promising means of regenerating pancreatic cells, whether directly or through its receptor agonists...
April 16, 2024: Current Diabetes Reviews
#32
JOURNAL ARTICLE
Lihong Wen, Zhexiang Fan, Weichang Huang, Yong Miao, Jiarui Zhang, Bingcheng Liu, Decong Zhu, Damao Dai, Jiaxian Zhang, Demengjie Le, Yufan Zhang, Qian Qu, Zhiqi Hu, Ruosi Chen
BACKGROUND: Depletion or permanent quiescence of the hair follicle stem cell (HFSC) pool underlies pathogenesis in androgenetic alopecia (AGA). Reactivation of quiescent HFSCs is considered an efficient treatment strategy for hair loss. The retinoic acid (RA) is critical to ensure stem cell homeostasis and function. However, little is known about whether RA regulates HFSC homeostasis. We aimed to investigate the impact of RA on HFSC homeostasis and the underlying mechanisms, in order to provide new potential targets for medical therapies of AGA...
April 17, 2024: Journal of the European Academy of Dermatology and Venereology: JEADV
#33
JOURNAL ARTICLE
Lorenzo Bonetti, Silvia Borsacchi, Alessandra Soriente, Alberto Boccali, Lucia Calucci, Maria Grazia Raucci, Lina Altomare
Injectable bone substitutes (IBSs) represent a compelling choice for bone tissue regeneration, as they can be exploited to optimally fill complex bone defects in a minimally invasive manner. In this context, in situ gelling methylcellulose (MC) hydrogels may be engineered to be free-flowing injectable solutions at room temperature and gels upon exposure to body temperature. Moreover, incorporating a suitable inorganic phase can further enhance the mechanical properties of MC hydrogels and promote mineralization, thus assisting early cell adhesion to the hydrogel and effectively guiding bone tissue regeneration...
April 17, 2024: Journal of Materials Chemistry. B, Materials for Biology and Medicine
#34
JOURNAL ARTICLE
Marcelo Reginato, Carlos A Ordónez-Parra, João Vitor S Messeder, Vinicius L G Brito, Agnes Dellinger, Ricardo Kriebel, Camilla Marra, Lilian Melo, Tatiana Cornelissen, Lisieux Fuzessy, Patricia Sperotto, Manuela Calderón-Hernández, Tadeu J Guerra, Constantin Kopper, Carolina Mancipe-Murillo, Marco A Pizo, Juan Mauricio Posada-Herrera, Érica Hasui, Wesley R Silva, Fernando A O Silveira
The recent availability of open-access repositories of functional traits has revolutionized trait-based approaches in ecology and evolution. Nevertheless, the underrepresentation of tropical regions and lineages remains a pervasive bias in plant functional trait databases, which constrains large-scale assessments of plant ecology, evolution, and biogeography. Here, we present MelastomaTRAITs 1.0, a comprehensive and updatable database of functional traits for the pantropical Melastomataceae, the ninth-largest angiosperm family with 177 genera and more than 5800 species...
April 17, 2024: Ecology
#35
JOURNAL ARTICLE
Jin Zhang, Yang Xiang, Quyang Yang, Jiqiu Chen, Lei Liu, Jian Jin, Shihui Zhu
The tissues or organs derived decellularized extracellular matrix carry immunogenicity and the risk of pathogen transmission, resulting in limited therapeutic effects. The cell derived dECM cultured in vitro can address these potential risks, but its impact on wound remodeling is still unclear. This study aimed to explore the role of decellularized extracellular matrix (dECM) extracted from adipose derived stem cells (ADSCs) in skin regeneration. Methods: ADSCs were extracted from human adipose tissue. Then we cultivated adipose-derived stem cell cells and decellularized ADSC-dECM for freeze-drying...
2024: Frontiers in Bioengineering and Biotechnology
#36
REVIEW
Hairong Jin, Zengqi Xue, Jinnv Liu, Binbin Ma, Jianfeng Yang, Lanjie Lei
Tissue damage and functional abnormalities in organs have become a considerable clinical challenge. Organoids are often applied as disease models and in drug discovery and screening. Indeed, several studies have shown that organoids are an important strategy for achieving tissue repair and biofunction reconstruction. In contrast to established stem cell therapies, organoids have high clinical relevance. However, conventional approaches have limited the application of organoids in clinical regenerative medicine...
2024: Biomaterials Research
#37
JOURNAL ARTICLE
Rachel A Yang, Stanley Cho, Sydney N Hughes, Michele L Sarazen
Rising anthropogenic carbon emissions have dire environmental consequences, necessitating remediative approaches, which includes use of solid sorbents. Here, aminopolymers (poly(ethylenimine) (PEI) and poly(propylenimineimine) (PPI)) are supported within solid mesoporous MIL-101(Cr) to examine effects of support defect density on aminopolymer-MOF interactions for CO2 uptake and stability during uptake-regeneration cycles. Using simulated flue gas (10 % CO2 in He), MIL-101(Cr)-ρhigh (higher defect density) shows 33 % higher uptake capacity per gram adsorbent than MIL-101(Cr)-ρlow (lower defect density) at 308 K, consistent with increased availability of undercoordinated Cr adsorption sites at missing linker defects...
April 16, 2024: ChemSusChem
#38
JOURNAL ARTICLE
Jiangshan Xu, Pengcheng Guo, Shijie Hao, Shuncheng Shangguan, Quan Shi, Giacomo Volpe, Keke Huang, Jing Zuo, Juan An, Yue Yuan, Mengnan Cheng, Qiuting Deng, Xiao Zhang, Guangyao Lai, Haitao Nan, Baihua Wu, Xinyi Shentu, Liang Wu, Xiaoyu Wei, Yujia Jiang, Xin Huang, Fengyu Pan, Yumo Song, Ronghai Li, Zhifeng Wang, Chuanyu Liu, Shiping Liu, Yuxiang Li, Tao Yang, Zhicheng Xu, Wensi Du, Ling Li, Tanveer Ahmed, Kai You, Zhen Dai, Li Li, Baoming Qin, Yinxiong Li, Liangxue Lai, Dajiang Qin, Junling Chen, Rong Fan, Yongyin Li, Jinlin Hou, Michael Ott, Amar Deep Sharma, Tobias Cantz, Axel Schambach, Karsten Kristiansen, Andrew P Hutchins, Berthold Göttgens, Patrick H Maxwell, Lijian Hui, Xun Xu, Longqi Liu, Ao Chen, Yiwei Lai, Miguel A Esteban
The mechanism by which mammalian liver cell responses are coordinated during tissue homeostasis and perturbation is poorly understood, representing a major obstacle in our understanding of many diseases. This knowledge gap is caused by the difficulty involved with studying multiple cell types in different states and locations, particularly when these are transient. We have combined Stereo-seq (spatiotemporal enhanced resolution omics-sequencing) with single-cell transcriptomic profiling of 473,290 cells to generate a high-definition spatiotemporal atlas of mouse liver homeostasis and regeneration at the whole-lobe scale...
April 16, 2024: Nature Genetics
#39
JOURNAL ARTICLE
Rong Zhang, Zhuannian Liu, Taoli Chen
Developing cost-effective and efficient photo-Fenton catalysts is crucial for advancing photo-Fenton technology. MoS2 is a representative transition metal disulfide with attractive photoresponsiveness, making it ideal for preparing composite photo-Fenton catalysts. In this study, natural molybdenite was innovatively utilized as a source of MoS2 (OM) to synthesize a low-cost and efficient Fe@MoS2 (OMF) composite photo-Fenton catalyst by comminution and adsorption, which was then applied to the remediation of antibiotic-contaminated water...
April 16, 2024: Photochemistry and Photobiology
#40
JOURNAL ARTICLE
Lauren Foltz, Nagashree Avabhrath, Jean-Marc Lanchy, Tyler Levy, Anthony Possemato, Majd Ariss, Bradley Peterson, Mark Grimes
Knowledge of cell signaling pathways that drive human neural crest differentiation into craniofacial chondrocytes is incomplete, yet essential for using stem cells to regenerate craniomaxillofacial structures. To accelerate translational progress, we developed a differentiation protocol that generated self-organizing craniofacial cartilage organoids from human embryonic stem cell-derived neural crest stem cells. Histological staining of cartilage organoids revealed tissue architecture and staining typical of elastic cartilage...
April 19, 2024: IScience
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