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https://www.readbyqxmd.com/read/28718631/a-copper-ii-paddlewheel-metal-organic-framework-with-exceptional-hydrolytic-stability-and-selective-adsorption-and-detection-ability-of-aniline-in-water
#1
Ya Chen, Bin Wang, Xiaoqing Wang, Lin-Hua Xie, Jinping Li, Yabo Xie, Jian-Rong Jeff Li
Copper(II) paddlewheel based metal-organic frameworks (CP-MOFs) represent a unique subclass of MOFs with highly predictable porous structures, facile syntheses, and functional open metal sites. However, lack of high hydrolytic stability is an obstacle for CP-MOFs in many practical applications. In this work, we report a new CP-MOF, [Cu4(tdhb)] (BUT-155), which is constructed from a judiciously designed carboxylate ligand with high coordination connectivity (octatopic), abundant hydrophobic substituents (six methyl groups), and substituent constrained geometry (tetrahedral backbone), tdhb8- (H8tdhb = 3,3',5,5'-tetra(3,5-dicarboxyphenyl)-2,2',4,4',6,6'-hexamethylbiphenyl))...
July 18, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28718622/graphene-sheet-induced-global-maturation-of-cardiomyocytes-derived-from-human-induced-pluripotent-stem-cells
#2
Jiaxian Wang, Chang Cui, Haiyan Nan, Yuanfang Yu, Yini Xiao, Ellen Poon, Gang Yang, Xijie Wang, Chenchen Wang, Lingsong Li, Kenneth Richard Boheler, Xu Ma, Xin Cheng, Zhenhua Ni, Minglong Chen
Human induced pluripotent stem cells (hiPSCs) can proliferate infinitely. Their ability to differentiate into cardiomyocytes provides abundant sources for disease modeling, drug screening and regenerative medicine. However, hiPSC-derived cardiomyocytes (hiPSC-CMs) display a low degree of maturation and fetal-like properties. Current in vitro differentiation methods do not mimic the structural, mechanical, and physiological properties of the cardiogenesis niche. Recently, we present an efficient cardiac maturation platform that combines hiPSCs monolayer cardiac differentiation with graphene substrate which is a biocompatible and superconductive material...
July 18, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28717506/injectable-scaffold-materials-differ-in-their-cell-instructive-effects-on-primary-human-myoblasts
#3
Eva Kildall Hejbøl, Jeeva Sellathurai, Prabha Damodaran Nair, Henrik Daa Schrøder
Scaffolds are materials used for delivery of cells for regeneration of tissues. They support three-dimensional organization and improve cell survival. For the repair of small skeletal muscles, injections of small volumes of cells are attractive, and injectable scaffolds for delivery of cells offer a minimally invasive technique. In this study, we examined in vitro the cell instructive effects of three types of injectable scaffolds, fibrin, alginate, and poly(lactic-co-glycolic acid)-based microparticles on primary human myoblasts...
January 2017: Journal of Tissue Engineering
https://www.readbyqxmd.com/read/28717027/regulation-of-the-calvin-benson-bassham-cycle-in-the-enigmatic-diatoms-biochemical-and-evolutionary-variations-on-an-original-theme
#4
REVIEW
Erik Jensen, Romain Clément, Stephen C Maberly, Brigitte Gontero
In Plantae, the Calvin-Benson-Bassham (CBB) cycle is highly regulated and most of its enzymes have been thoroughly studied. Since diatoms arose as a result of secondary endosymbiosis with one or more Plantae ancestors, their precise evolutionary history is enigmatic and complex resulting in biochemical variations on the original CBB cycle theme. The Rubisco Michaelis constant for CO2 is higher in diatoms than land plants and the nuclear-encoded Rubisco activase in Plantae is replaced by an analogous chloroplast-encoded CbbX (Calvin-Benson-Bassham protein X) in diatoms...
September 5, 2017: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
https://www.readbyqxmd.com/read/28716720/met-signaling-mediates-intestinal-crypt-villus-development-regeneration-and-adenoma-formation-and-is-promoted-by-stem-cell-cd44-isoforms
#5
Sander P J Joosten, Jurrit Zeilstra, Harmen van Andel, R Clinton Mijnals, Joost Zaunbrecher, Annet A M Duivenvoorden, Marc van de Wetering, Hans Clevers, Marcel Spaargaren, Steven T Pals
BACKGROUND & AIMS: Resistance of metastatic human colorectal cancer cells to drugs that block epidermal growth factor receptor (EGFR) signaling could be caused by aberrant activity of other receptor tyrosine kinases, activating overlapping signaling pathways. One of these receptor tyrosine kinases could be MET, the receptor for hepatocyte growth factor (HGF). We investigated how MET signaling, and its interaction with CD44 (a putative MET co-receptor regulated by Wnt signaling and highly expressed by intestinal stem cells [ISCs] and adenomas) affects intestinal homeostasis, regeneration, and adenoma formation in mini-gut organoids and mice...
July 14, 2017: Gastroenterology
https://www.readbyqxmd.com/read/28716380/erratum-to-human-liver-regeneration-in-advanced-cirrhosis-is-organized-by-the-portal-tree-j-hepatol-66-2017-778-786
#6
Katalin Dezső, András Rókusz, Edina Bugyik, Armanda Szücs, András Szuák, Bence Dorogi, Mátyás Kiss, Ágnes Nemeskéri, Péter Nagy, Sándor Paku
No abstract text is available yet for this article.
August 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28715772/stability-of-single-dispersed-silver-nanoparticles-in-natural-and-synthetic-freshwaters-effects-of-dissolved-oxygen
#7
Xiaoyan Zou, Penghui Li, Jie Lou, Xiaoyan Fu, Hongwu Zhang
Silver nanoparticles (AgNPs) are increasingly used in various commercial products. This increased use raises ecological concerns because of the large release of AgNPs into the environment. Once released, the local water chemistry has the potential to influence the environmental fates and behaviors of AgNPs. The impacts of dissolved oxygen and natural organic matter (NOM) on the dissolution and stability of AgNPs were investigated in synthetic and natural freshwaters for 7 days. In synthetic freshwater, the aggregation of AgNPs occurred due to the compression of the electric double layer, accompanied by the dissolution of AgNPs...
July 14, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28715169/fabrication-of-biocompatible-functional-and-transparent-hybrid-films-based-on-silk-fibroin-and-epoxy-silane-for-biophotonics
#8
Robson Rosa da Silva, Mauricio Cavicchioli, Lais Rocalho de Lima, Caio Gomide Otoni, Hernane da Silva Barud, Silvia Helena Santagneli, Agnieszka Tercjak, André Capaldo Amaral, Renata Aquino Carvalho, Sidney José Lima Ribeiro
In this work we explored the fabrication of flexible and transparent hybrids of silk fibroin and epoxy modified siloxane for photonic applications. It is well known that regenerated silk fibroin (SF) solutions can form free-standing films with high transparency. Although SF has a restricted number of chemically reactive side groups, the main issues of as-casted pristine SF films regard the high solubility into aqueous media, brittleness, and low thermal stability. The design of SF films with enhanced functionality but yet highly transparent triggers new opportunities on broader range of applications in biophotonics...
July 17, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28714852/the-small-molecule-mimetic-agonist-trimebutine-of-adhesion-molecule-l1-contributes-to-functional-recovery-after-spinal-cord-injury-in-mice
#9
Junping Xu, Chengliang Hu, Qiong Jiang, Hongchao Pan, Huifan Shen, Melitta Schachner
Curing spinal cord injury (SCI) in mammals is a daunting task because of the lack of permissive mechanisms and strong inhibitory responses at and around the lesion. The neural cell adhesion molecule L1CAM (L1) has been shown to favor axonal regrowth and enhance neuronal survival and synaptic plasticity, and thus constitutes a viable target to promote regeneration after SCI. Since delivery of full-length L1 or its extracellular domain could encounter difficulties in translation to therapy in humans, we have identified several small organic compounds that bind to L1 and stimulate neuronal survival, neuronal migration, and neurite outgrowth in an L1-dependent manner...
July 14, 2017: Disease Models & Mechanisms
https://www.readbyqxmd.com/read/28714595/telocytes-in-normal-and-keratoconic-human-cornea-an-immunohistochemical-and-transmission-electron-microscopy-study
#10
Mirca Marini, Rita Mencucci, Irene Rosa, Eleonora Favuzza, Daniele Guasti, Lidia Ibba-Manneschi, Mirko Manetti
Telocytes (TC) are typically defined as cells with telopodes by their ultrastructural features. Their presence was reported in the interstitium of various organs in vertebrates, including humans. However, no study has yet described the presence of TC in the human eye and in particular, within the stromal compartment of the cornea. To address this issue, samples of normal and pathologic (keratoconic) human corneas were tested by immunohistochemistry for CD34, platelet-derived growth factor receptor α (PDGFRα) and c-kit/CD117 or examined by transmission electron microscopy...
July 17, 2017: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/28714033/evaluation-of-velvet-antler-total-protein-effect-on-bone-marrow%C3%A2-derived-endothelial-progenitor-cells
#11
Xiang Xiao, Lin Li, Shuqiang Xu, Min Mao, Ruiyan Pan, Yanjun Li, Jiayun Wu, Li Huang, Xiaoyun Zheng
Lu Rong, velvet antler (VA), is a traditional Chinese medicine, which is used as a food supplement and therapeutic drug in China, Japan, Russia, New Zealand and Southeast Asia. The regenerative characteristics of VA have resulted in great research interest, particularly regarding the fields of organ grafting and stem cell differentiation. Various VA proteomic studies verified that proteins act as the primary bioactive components of VA. The present study aimed to investigate if VA proteins (VA‑pro) influence endothelial progenitor cell (EPC) viability...
July 15, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28710142/perspective-neuroregenerative-nutrition
#12
Dennis A Steindler, Brent A Reynolds
Good health while aging depends upon optimal cellular and organ functioning that contribute to the regenerative ability of the body during the lifespan, especially when injuries and diseases occur. Although diet may help in the maintenance of cellular fitness during periods of stability or modest decline in the regenerative function of an organ, this approach is inadequate in an aged system, in which the ability to maintain homeostasis is further challenged by aging and the ensuing suboptimal functioning of the regenerative unit, tissue-specific stem cells...
July 2017: Advances in Nutrition
https://www.readbyqxmd.com/read/28710028/gene-expression-profiles-of-fin-regeneration-in-loach-paramisgurnus-dabryanu
#13
Li Li, Jingya He, Linlin Wang, Weihua Chen, Zhongjie Chang
Teleost fins can regenerate accurate position-matched structure and function after amputation. However, we still lack systematic transcriptional profiling and methodologies to understand the molecular basis of fin regeneration. After histological analysis, we established a suppression subtraction hybridization library containing 418 distinct sequences expressed differentially during the process of blastema formation and differentiation in caudal fin regeneration. Genome ontology and comparative analysis of differential distribution of our data and the reference zebrafish genome showed notable subcategories, including multi-organism processes, response to stimuli, extracellular matrix, antioxidant activity, and cell junction function...
July 11, 2017: Gene Expression Patterns: GEP
https://www.readbyqxmd.com/read/28709099/halide-removal-from-waters-by-silver-nanoparticles-and-hydrogen-peroxide
#14
A M S Polo, J J Lopez-Peñalver, J Rivera-Utrilla, U Von Gunten, M Sánchez-Polo
The objective of this study was to remove halides from waters by silver nanoparticles (AgNPs) and hydrogen peroxide (H2O2). The experimental parameters were optimized and the mechanism involved was also determined. The AgNP/H2O2 process proved efficacious for bromide and chloride removal from water through the selective precipitation of AgCl and AgBr on the AgNP surface. The optimal AgNP and H2O2 concentrations to be added to the solution were determined for the halide concentrations under study. The removal of Cl(-) and Br(-) anions was more effective at basic pH, reaching values of up to 100% for both ions...
July 11, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28708835/green-and-facile-approach-for-enhancing-the-inherent-magnetic-properties-of-carbon-nanotubes-for-water-treatment-applications
#15
Mohamed Ateia, Christian Koch, Stanislav Jelavić, Ann Hirt, Jonathan Quinson, Chihiro Yoshimura, Matthew Johnson
Current methods for preparing magnetic composites with carbon nanotubes (MCNT) commonly include extensive use of treatment with strong acids and result in massive losses of carbon nanotubes (CNTs). In this study we explore the potential of taking advantage of the inherent magnetic properties associated with the metal (alloy or oxide) incorporated in CNTs during their production. The as-received CNTs are refined by applying a permanent magnet to a suspension of CNTs to separate the high-magnetic fraction; the low-magnetic fraction is discarded with the solvent...
2017: PloS One
https://www.readbyqxmd.com/read/28707806/selective-adsorption-and-separation-of-organic-dyes-with-spherical-polyelectrolyte-brushes-and-compressed-co2
#16
Rui Zhang, Zhenchuan Yu, Yuan Yao, Xiaoyan Hou, Qizhe Shen, Lei Wang, Xuhong Guo, Junwei Wang, Xuedong Zhu
Direct discharge of industry organic dyes has caused serious environmental pollution. Herein, we proposed a rational designed spherical polyelectrolyte brushes (SPB) with cationic charges, polystyrene-poly(2-aminoethylmethacrylate hydrochloride) (PS-PAEMH), as the absorbent and compressed carbon dioxide as the anti-solvent to separate the anionic dye, eosin Y (EY) from a solution of mixed dyes. The adsorption behavior of EY onto PS-PAEMH was highly dependent on CO2 pressure, contact time and initial concentration, and the maximum adsorption capacity of PS-PAEMH was 335...
July 14, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28707508/design-and-fabrication-of-porous-biodegradable-scaffolds-a-strategy-for-tissue-engineering
#17
Vahideh Raeisdasteh Hokmabad, Soodabeh Davaran, Ali Ramazani, Roya Salehi
Current strategies of tissue engineering are focused on the reconstruction and regeneration of damaged or deformed tissues by grafting of cells with scaffolds and biomolecules. Recently, much interest is given to scaffolds which are based on mimic the extracellular matrix that have induced the formation of new tissues. To return functionality of the organ, the presence of a scaffold is essential as a matrix for cell colonization, migration, growth, differentiation and extracellular matrix deposition, until the tissues are totally restored or regenerated...
July 14, 2017: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/28705953/micrornas-in-the-skin-role-in-development-homoeostasis-and-regeneration
#18
REVIEW
Steven Horsburgh, Nicola Fullard, Mathilde Roger, Abbie Degnan, Stephen Todryk, Stefan Przyborski, Steven O'Reilly
The skin is the largest organ of the integumentary system and possesses a vast number of functions. Due to the distinct layers of the skin and the variety of cells which populate each, a tightly regulated network of molecular signals control development and regeneration, whether due to programmed cell termination or injury. MicroRNAs (miRs) are a relatively recent discovery; they are a class of small non-coding RNAs which possess a multitude of biological functions due to their ability to regulate gene expression via post-transcriptional gene silencing...
August 1, 2017: Clinical Science (1979-)
https://www.readbyqxmd.com/read/28705112/pcl-tcp-wet-spun-scaffolds-carrying-antibiotic-loaded-microspheres-for-bone-tissue-engineering
#19
Elbay Malikmammadov, Tugba Endogan Tanir, Aysel Kiziltay, Vasif Hasirci, Nesrin Hasirci
Scaffolds produced for tissue engineering applications are proven to be promising alternatives to be used in healing and regeneration of injured tissues and organs. In this study, porous and fibrous poly(ε-caprolactone) (PCL) scaffolds were prepared by wet spinning technique and modified by addition of tricalcium phosphate (TCP) and by immobilizing gelatin onto fibers. Meanwhile, gelatin microspheres carrying Ceftriaxone sodium (CS), a model antibiotic, were added onto the scaffolds and antimicrobial activity of CS was investigated against Escherichia coli (E...
July 14, 2017: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/28704129/electromagnetic-information-transfer-through-aqueous-system
#20
Alberto Foletti, Mario Ledda, Maria Grazia Lolli, Settimio Grimaldi, Antonella Lisi
Several beneficial effects of the electromagnetic information transfer through aqueous system (EMITTAS) procedure have previously been reported in vitro. The clinical potential of this procedure has also started to be evaluated. Information flow in biological systems can be investigated through chemical and molecular approaches or by a biophysical approach focused on endogenous electrodynamic activities. Electromagnetic signals are endogenously generated at different levels of the biological organization and, likely, play an active role in synchronizing internal cell function or local/systemic adaptive response...
July 13, 2017: Electromagnetic Biology and Medicine
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