Eun Jung Kim, Caressa Chen, Rebecca Gologorsky, Ana Santandreu, Alonso Torres, Nathan Wright, Mark S Goodin, Jarrett Moyer, Benjamin W Chui, Charles Blaha, Paul Brakeman, Shant Vartanian, Qizhi Tang, H David Humes, William H Fissell, Shuvo Roy
The definitive treatment for end-stage renal disease is kidney transplantation, which remains limited by organ availability and post-transplant complications. Alternatively, an implantable bioartificial kidney could address both problems while enhancing the quality and length of patient life. An implantable bioartificial kidney requires a bioreactor containing renal cells to replicate key native cell functions, such as water and solute reabsorption, and metabolic and endocrinologic functions. Here, we report a proof-of-concept implantable bioreactor containing silicon nanopore membranes to offer a level of immunoprotection to human renal epithelial cells...
August 29, 2023: Nature Communications