keyword
https://read.qxmd.com/read/37842943/the-impact-of-anticoagulation-therapy-on-kidney-function-in-patients-with-atrial-fibrillation-and-chronic-kidney-disease
#21
REVIEW
Jelena Simic, Miroslav Mihajlovic, Nevena Zec, Vladan Kovacevic, Milan Marinkovic, Nebojsa Mujovic, Tatjana Potpara
INTRODUCTION: Atrial fibrillation (AF) and chronic kidney disease (CKD) are closely related. These diseases share common risk factors and are associated with increased risk of thromboembolic events. Choosing the appropriate oral anticoagulant therapy (OAC) in patients with AF and CKD is challenging. Deterioration of renal function is common in patients with AF treated with OACs, although not all OACs affect the kidneys equally. AREAS COVERED: In this review, we aim to summarize the current knowledge of the prevention of thromboembolic events in patients with AF and CKD, focusing on the impact of specific OAC agents on renal function...
October 16, 2023: Expert Review of Cardiovascular Therapy
https://read.qxmd.com/read/37841948/minocycline-induced-hyperpigmentation-importance-of-early-diagnosis
#22
JOURNAL ARTICLE
Tomohide Okinaka, Kento Fukumitsu, Nozomi Okamura, Liya Wang, Yoshihiro Ohishi, Yoshiko Miyazaki, Takashi Matono
A 75-year-old woman on hemodialysis for end-stage renal failure due to polycystic kidney disease developed dark spots on her limbs. She had been treated for extended spectrum beta-lactamase-producing Escherichia coli bacteremia by a rectovaginal fistula and was on long-term oral minocycline (cumulative dose 45 g). Physical examination revealed dark patches on her forearms and lower legs but no trunk hyperpigmentation or visual impairment. Blood tests were normal. Skin biopsy confirmed minocycline-induced hyperpigmentation...
2023: IDCases
https://read.qxmd.com/read/37811033/calciphylaxis-during-the-course-of-psoriatic-arthritis-patient-is-it-coincidence-a-case-report
#23
Naram Khalayli, Yara Hodifa, Amr Hodaifa, Omar Alsamarrai, Maysoun Kudsi
INTRODUCTION AND IMPORTANCE: Calciphylaxis manifests clinically by skin ischemia and necrosis and histologically by calcification of dermal arterioles. Usually, it occurs in patients with end-stage renal disease on dialysis or in patients who had a kidney transplant. Here, the authors present a case of calciphylaxis occurring in a patient with psoriasis and psoriatic arthritis. CASE PRESENTATION: A 66-year-old Syrian male with a history of psoriatic arthritis presented for evaluation of 2-month nonpainful ulcers on his feet and hands that were treated with warfarin...
October 2023: Annals of Medicine and Surgery
https://read.qxmd.com/read/37809218/calciphylaxis-secondary-to-vitamin-d-supplementation
#24
Joana Costa E Silva, José N Ramos
Calciphylaxis is a rare cutaneous disease consisting of purpuric and necrotic lesions, and it affects mostly patients with renal failure. More rarely, it can be observed in patients with preserved renal function, acquiring the name of non-uremic calciphylaxis (NUC). Although its pathophysiology is under uncertainty, many etiological factors have been implicated. This report describes a patient who developed NUC, possibly triggered by vitamin D supplementation.
September 2023: Curēus
https://read.qxmd.com/read/37795477/the-safety-and-efficacy-of-direct-oral-anticoagulants-among-chronic-kidney-disease-patients-on-dialysis-with-non-valvular-atrial-fibrillation-a-meta-analysis
#25
REVIEW
Jerahmeel Aleson L Mapili, Lloyd Christopher S Lim, Bianca M Velando, Jaime Alfonso M Aherrera
BACKGROUND: Individuals with chronic kidney disease (CKD) on dialysis are at an increased risk of stroke and embolic events especially in the presence of atrial fibrillation (AF). Vitamin K antagonists (VKA), including warfarin, have been used for decades for anticoagulation among CKD patients on dialysis with AF but recent evidence has shown increased bleeding. Direct oral anticoagulants (DOAC) have been emerging as an alternative to VKA which, based on several observational cohort studies, are at least as efficacious and safe as VKA...
2023: Frontiers in Cardiovascular Medicine
https://read.qxmd.com/read/37748453/alleviation-of-oxidative-stress-during-hemodialysis-sessions-by-hemodialysis-membrane-innovation-a-multidisciplinary-perspective
#26
REVIEW
Yupei Li, Xinyao Luo, Mei Yang, Baihai Su
Oxidative stress is prevalent in end-stage kidney disease patients receiving chronic hemodialysis and is associated with heavy cardiovascular disease burdens and increased mortality risks. Hemoincompatible hemodialysis membranes per se contribute to the activation of oxidative reactions and the generation of oxygen free radicals. Since the early 1990s, vitamin E-coated membranes have been extensively used in hemodialysis patients to reduce oxidative stress during hemodialysis sessions. However, the beneficial effects of vitamin E-coated membranes versus unmodified synthetic membranes on long-term patient-centered outcomes, such as survival, quality of life, and prevalence of cardiovascular diseases, remain controversial...
2023: Blood Purification
https://read.qxmd.com/read/37648582/efficacy-and-safety-of-direct-oral-anticoagulants-vs-vitamin-k-antagonists-in-patients-with-atrial-fibrillation-and-end-stage-renal-disease-on-hemodialysis-a-systematic-review-and-meta-analysis
#27
JOURNAL ARTICLE
Ioannis Kyriakoulis, Anastasia Adamou, Iliana Stamatiou, David Dimitris Chlorogiannis, Ioannis Kardoutsos, Despoina Koukousaki, George Ntaios
BACKGROUND: The prevalence of atrial fibrillation (AF) in individuals with end-stage renal disease (ESRD) on chronic hemodialysis is increasing. The optimal anticoagulant choice in this population is unclear since these patients were excluded from the pivotal randomized controlled trials (RCTs) of direct oral anticoagulants (DOACs) vs. vitamin K antagonists (VKAs) in the general AF population. We aimed to assess the efficacy and safety of DOACs vs. VKAs in patients with AF and ESRD on chronic hemodialysis through a systematic review and meta-analysis of all available evidence...
August 28, 2023: European Journal of Internal Medicine
https://read.qxmd.com/read/37644033/feasibility-of-an-implantable-bioreactor-for-renal-cell-therapy-using-silicon-nanopore-membranes
#28
JOURNAL ARTICLE
Eun Jung Kim, Caressa Chen, Rebecca Gologorsky, Ana Santandreu, Alonso Torres, Nathan Wright, Mark S Goodin, Jarrett Moyer, Benjamin W Chui, Charles Blaha, Paul Brakeman, Shant Vartanian, Qizhi Tang, H David Humes, William H Fissell, Shuvo Roy
The definitive treatment for end-stage renal disease is kidney transplantation, which remains limited by organ availability and post-transplant complications. Alternatively, an implantable bioartificial kidney could address both problems while enhancing the quality and length of patient life. An implantable bioartificial kidney requires a bioreactor containing renal cells to replicate key native cell functions, such as water and solute reabsorption, and metabolic and endocrinologic functions. Here, we report a proof-of-concept implantable bioreactor containing silicon nanopore membranes to offer a level of immunoprotection to human renal epithelial cells...
August 29, 2023: Nature Communications
https://read.qxmd.com/read/37641427/frequent-vascular-access-thrombosis-in-a-patient-with-end-stage-kidney-disease-on-hemodialysis
#29
REVIEW
David Kearney, Amanda Leonberg-Yoo, Raphael Cohen
Vascular access thrombosis (VAT) is common among patients receiving hemodialysis and leads to missed dialysis treatments, hospitalizations, catheter placement, and graft/fistula abandonment. This article reviews the association between hypercoagulability and VAT and the high prevalence of hypercoagulable states in end-stage kidney disease (ESKD). This article reviews the role of antithrombotic and anticoagulant medications in preventing VAT. The article concludes by reviewing the unique challenges of using vitamin K antagonists in patients with ESKD...
2023: Seminars in Dialysis
https://read.qxmd.com/read/37629597/the-protective-effect-of-vitamin-d-on-dementia-risk-in-hemodialysis-patients
#30
JOURNAL ARTICLE
Chih-Lang Lin, Wan-Ming Chen, An-Tzu Jao, Ben-Chang Shia, Szu-Yuan Wu
BACKGROUND: Patients with end-stage renal disease (ESRD) undergoing hemodialysis are at an elevated risk of developing dementia, potentially linked to the high prevalence of vitamin D deficiency in this population, which may contribute to cognitive impairment. Nevertheless, the impact of vitamin D supplementation on the risk of dementia in hemodialysis patients remains uncertain, necessitating further investigation to elucidate the potential benefits of vitamin D intervention in this vulnerable group...
August 13, 2023: Life
https://read.qxmd.com/read/37605063/cardiovascular-and-renal-outcomes-in-patients-with-atrial-fibrillation-and-stage-4-5-chronic-kidney-disease-receiving-direct-oral-anticoagulants-a-multicenter-retrospective-cohort-study
#31
JOURNAL ARTICLE
Yuan Lin, Tze-Fan Chao, Ming-Lung Tsai, Chin-Ju Tseng, Te-Hsiung Wang, Chih-Hsiang Chang, Yu-Sheng Lin, Ning-I Yang, Pao-Hsien Chu, Ming-Jui Hung, Victor Chien-Chia Wu, Tien-Hsing Chen
The role of direct oral anticoagulants (DOAC) in patients with atrial fibrillation (AF) and stage 4-5 chronic kidney disease (CKD) is controversial. Electronic medical records from 2012 to 2021 were retrieved for patients with AF and stage 4-5 CKD receiving oral anticoagulants. Patients were separated into those receiving DOACs (dabigatran, rivaroxaban, apixaban, or edoxaban) or vitamin K antagonists (VKA). Primary outcomes included ischemic stroke (IS), systemic thrombosis (SE), major bleeding, gastrointestinal bleeding, hemorrhagic stroke, acute myocardial infarction, cardiovascular death, and all-cause death...
August 21, 2023: Journal of Thrombosis and Thrombolysis
https://read.qxmd.com/read/37594666/prescription-of-doacs-in-patients-with-atrial-fibrillation-at-different-stages-of-renal-insufficiency
#32
REVIEW
Kai Hahn, Mathias Lamparter
Atrial fibrillation (AF) and renal insufficiency often coexist and are increasingly prevalent with advancing age. Both the risk of thromboembolic events and bleeding propensity are higher in patients with AF and impaired renal function versus those with good renal health. Direct oral anticoagulants (DOACs) are being increasingly preferred over vitamin K antagonists (VKAs) in the treatment of patients with AF and impaired renal function as VKAs may accelerate progression of chronic kidney disease. DOACs, however, are eliminated by the kidneys to varying degrees, and their dosages must be adapted in accordance with renal function...
October 2023: Advances in Therapy
https://read.qxmd.com/read/37558172/nutrition-in-children-with-chronic-kidney-disease-how-to-thrive
#33
REVIEW
Robert H Mak, Arpana Iyengar, Wai Ming Lai, Louise McAlister, Eduardo A Oliveira, Hong Xu, Hui Kim Yap, Rukshana Shroff
The nutritional status and management of children with chronic kidney disease (CKD) are complex and require a combined pediatric nephrology team work approach with physicians, nutritionists, nurses, and physical/occupational therapists. Prospective observational studies such as Children with CKD in the US, the 4C study in Europe and the International Pediatric Peritoneal Dialysis Network have advanced the field. However, most recommendations and guidelines from international task forces such as Kidney Diseases Improving Global Outcomes and Pediatric Renal Nutrition Taskforce are opinion-based rather than evidence-based...
August 7, 2023: Journal of Renal Nutrition
https://read.qxmd.com/read/37539955/interventions-for-chronic-kidney-disease-in-people-with-sickle-cell-disease
#34
REVIEW
Noemi Ba Roy, Abigail Carpenter, Isabella Dale-Harris, Carolyn Dorée, Lise J Estcourt
BACKGROUND: Sickle cell disease (SCD), one of the commonest severe monogenic disorders, is caused by the inheritance of two abnormal haemoglobin (beta-globin) genes. SCD can cause severe pain, significant end-organ damage, pulmonary complications, and premature death. Kidney disease is a frequent and potentially severe complication in people with SCD. Chronic kidney disease (CKD) is defined as abnormalities of kidney structure or function present for more than three months. Sickle cell nephropathy refers to the spectrum of kidney complications in SCD...
August 4, 2023: Cochrane Database of Systematic Reviews
https://read.qxmd.com/read/37482192/quantitative-determination-of-plasma-free-and-total-concentrations-of-antivitamin-k-drugs-using-a-new-sensitive-and-rapid-lc-ms-ms-method-application-in-hemodialysis-patients
#35
JOURNAL ARTICLE
Touria Mernissi, Julien Demagny, Mailys Le Guyader, Marianne Renou, Gabriel Choukroun, Saïd Kamel, Sophie Liabeuf, Sandra Bodeau
BACKGROUND AND AIMS: Vitamin K antagonists (VKAs) are the first-line anticoagulants used in end stage renal disease. This population experiences a significant variability in their International Normalized Ratio (INR) over time. There is a need for methods allowing the study of the pharmacokinetics of free and total concentrations of VKAs to explain INR variability. MATERIALS AND METHODS: We developed and validated a high-performance liquid chromatography-tandem mass spectrometry method allowing the quantification of warfarin and fluindione free and total plasma concentrations...
July 21, 2023: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://read.qxmd.com/read/37473660/sex-differences-in-the-association-between-vitamin-d-and-early-stage-chronic-kidney-disease-a%C3%A2-population-based-study
#36
JOURNAL ARTICLE
Ting-An Yang, Jau-Yuan Chen, Chieh-An Lin, Yi-Chuan Chen, Wei Yu, Hsiung Ying Huang, Xue-Jie Xiong, Wen-Cheng Li
Vitamin D deficiency (VDD) is commonly observed in people with late-stage chronic kidney disease (CKD) and end-stage renal disease; it has also been associated with the progression of kidney disease. We hypothesized that VDD played a role in early-stage chronic kidney disease as well. Thus, this cross-sectional study aimed to evaluate the association between serum 25-hydroxyvitamin D concentration and CKD stages 1 through 3 (early-stage CKD) in a relatively healthy population in China. A total of 3142 Chinese individuals were included in this cross-sectional study...
May 20, 2023: Nutrition Research
https://read.qxmd.com/read/37456428/plasma-homocysteine-levels-and-cardiovascular-events-in-patients-with-end-stage-renal-disease-a-systematic-review
#37
REVIEW
Abdulilah A ALSolami, Abdulrhman A Almalki, Saleh Yousef Alhedyan, Abdulmajeed Alghamdi, Sultan M Alzahrani, Wesam R Dause, Fahad A Hamdi, Mohannad T Howladar, Islam A Ibrahim
BACKGROUND: Patients with chronic renal disease or failure are at a heightened risk of mortality due to cardiovascular disease (CVD), which is a predominant cause of death in this population. Hyperhomocysteinemia is prevalent in patients with end-stage renal disease (ESRD), which may increase their susceptibility to CVD. METHODS: We conducted a comprehensive search of PubMed, Science Direct, and Google Scholar for articles published between 2003 and February 2023, using a combination of keywords such as "plasma homocysteine levels," "hyperhomocysteinemia," "end-stage renal disease," "renal failure," "kidney failure," "cardiovascular events," "cardiovascular disease," "myocardial infarction," "coronary artery disease," and "stroke...
June 2023: Curēus
https://read.qxmd.com/read/37391399/vitamin-d-deficiency-contributes-to-the-diabetic-kidney-disease-progression-via-increase-zeb1-zeb2-expressions
#38
JOURNAL ARTICLE
Cláudia Silva Souza, Amanda Lima Deluque, Beatriz Magalhães Oliveira, Ana Lívia Dias Maciel, Cleonice Giovanini, Patrícia Aline Boer, Francisco José Albuquerque de Paula, Roberto Silva Costa, Heloísa Della Colleta Franscecato, Lucas Ferreira de Almeida, Terezila Machado Coimbra
BACKGROUND: Diabetic kidney disease (DKD) remains one of the main causes of end-stage renal disease (ESRD) and mortality in diabetic patients worldwide. Vitamin D deficiency (VitDD) is one of the main consequences of different chronic kidney disease (CKD) types and is associated with rapid progression to ESRD. Nevertheless, the mechanisms that lead to this process are poorly understood. This study aimed to characterize a model of diabetic nephropathy progression in VitDD and the epithelial-mesenchymal-transition (EMT) role in these processes...
July 1, 2023: Nutrition & Diabetes
https://read.qxmd.com/read/37391133/decreased-levels-of-perfluoroalkyl-substances-in-patients-receiving-hemodialysis-treatment
#39
JOURNAL ARTICLE
Jih-Kai Huang, Yun-Shiuan Chuang, Ping-Hsun Wu, Chi-Jung Tai, Jye-Ru Lin, Mei-Chuan Kuo, Yi-Wen Chiu, Ping-Chi Hsu, Ming-Tsang Wu, Samira Salihovic, Yi-Ting Lin
Perfluoroalkyl substances (PFAS) have been reported to be harmful to multiple organs in the human body. Based on a previous study suggesting that hemodialysis (HD) may be a means of eliminating PFAS from the human body, we aimed to compare the serum PFAS concentrations of patients undergoing regular HD, patients with chronic kidney disease (CKD) and controls. Additionally, we also investigated the correlation between PFAS and biochemical data, as well as concurrent comorbidities. We recruited 301 participants who had been on maintenance dialysis for >90 days, 20 participants with stage 5 non-dialysis CKD, and 55 control participants who did not have a diagnosis of kidney disease, with a mean creatinine level of 0...
June 28, 2023: Science of the Total Environment
https://read.qxmd.com/read/37351832/parathyroidectomy-and-survival-in-a-cohort-of-italian-dialysis-patients-results-of-a-multicenter-observational-prospective-study
#40
JOURNAL ARTICLE
Lida Tartaglione, Silverio Rotondi, Filippo Aucella, Mario Bonomini, Maria Rosa Caruso, Francesco Casino, Carlo Cuzziol, Alessio Farcomeni, Armando Filippini, Carlo Lomonte, Rocco Marinelli, Davide Rolla, Filomena Rubino, Giuseppe Seminara, Marzia Pasquali, Sandro Mazzaferro
BACKGROUND: Severe secondary hyperparathyroidism (SHPT) is associated with mortality in end stage kidney disease (ESKD). Parathyroidectomy (PTX) becomes necessary when medical therapy fails, thus highlighting the interest to compare biochemical and clinical outcomes of patients receiving either medical treatment or surgery. METHODS: We aimed to compare overall survival and biochemical control of hemodialysis patients with severe hyperparathyroidism, treated by surgery or medical therapy followed-up for 36 months...
June 23, 2023: Journal of Nephrology
keyword
keyword
159225
2
3
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.