Sabrina Haroon, Andrew Davenport, Lieng-Hsi Ling, Bee-Choo Tai, Lynette-Li-San Teo, Leon Schurgers, Zhaojin Chen, Rukshana Shroff, Dagmar-Christiane Fischer, Priyanka Khatri, Sanmay Low, Jia-Neng Tan, Horng-Ruey Chua, Boon-Wee Teo, Ching-Ching Ong, Srinivas Subramanian, Xi-Er Yeo, Weng-Kin Wong, Titus-Wai-Leong Lau
INTRODUCTION: Vitamin K deficiency among patients on hemodialysis (HD) affects the function of matrix GLA protein (MGP), a potent vitamin K-dependent inhibitor of vascular calcification (VC). METHODS: We conducted a single-center randomized controlled trial (RCT) on maintenance HD patients to examine if vitamin K2 supplementation can reduce progression of coronary artery calcification (CAC) over an 18-month study period. Patients were randomized to vitamin K2 group receiving menaquinone-7360 μg 3 times/wk or control group...
September 2023: KI Reports