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https://read.qxmd.com/read/38523044/consensus-of-the-brazilian-association-of-hematology-hemotherapy-and-cellular-therapy-on-patient-blood-management-preoperative-phase-preoperative-management-of-the-patient-s-anemia
#1
JOURNAL ARTICLE
Bruno Deltreggia Benites, Flavia Leite, Selma Soriano, Roberto Luiz da Silva, Susankerle de Oliveira Costa Alves, Silvia Renata Cornélio Parolin Rizzo, Guilherme Rabello, Dante Mario Langhi Junior
Managing anemia before surgery is extremely important as it is a clinical condition that can significantly increase surgical risk and affect patient outcomes. Anemia is characterized by a reduction in the number of red blood cells or hemoglobin levels leading to a lower oxygen-carrying capacity of the blood. Proper treatment requires a multifaceted approach to ensure patients are in the best possible condition for surgery and to minimize potential complications. The challenge is recognizing anemia early and implementing a timely intervention to correct it...
March 11, 2024: Hematology, Transfusion and Cell Therapy
https://read.qxmd.com/read/38523042/consensus-of-the-brazilian-association-of-hematology-hemotherapy-and-cellular-therapy-on-patient-blood-management-definition-of-patient-blood-management
#2
JOURNAL ARTICLE
Juan Carlos Montano-Pedroso, Maria Cristina Martins de Almeida Macedo, Silvana Biagini, Glaciano Ribeiro, José Francisco Comenalli Marques Junior, Silvia Renata Cornélio Parolin Rizzo, Guilherme Rabello, Dante Mario Langhi Junior
Managing the patient's blood and hematopoietic system is like managing any of the other organs and organ systems during patient care. Specialists control the heart, kidneys, endocrine system, etc. and the patient's blood requires similar clinical treatment. The hematopoietic system and its circulatory products are fundamental for the healthy functioning of the human body. In simple terms, Patient Blood Management (PBM) is an organized, patient-centered approach in which the entire healthcare team coordinates efforts to improve outcomes by managing and preserving the patient's own blood...
March 8, 2024: Hematology, Transfusion and Cell Therapy
https://read.qxmd.com/read/38521627/consensus-of-the-brazilian-association-of-hematology-hemotherapy-and-cellular-therapy-on-patient-blood-management-preoperative-clinical-and-laboratory-assessment-of-the-patient
#3
JOURNAL ARTICLE
Roberto Luiz da Silva, Bruno Deltreggia Benites, Flavia Leite, Selma Soriano, Susankerle de Oliveira Costa Alves, Silvia Renata Cornélio Parolin Rizzo, Guilherme Rabello, Dante Mario Langhi Junior
The preoperative clinical and laboratory evaluations of the patient is an essential step to ensure the safety and success of any surgical procedure. This assessment aims to identify any underlying medical conditions and risk factors and determine suitability for surgery. With this step, the medical team can adapt the care plan to meet each patient's specific needs, increasing the chances of a successful procedure. Good clinical assessment and comprehensive laboratory testing, when integrated into a Patient Blood Management approach, are invaluable in promoting safety of care, reducing transfusion risks, improving surgical outcomes, and optimizing resource utilization...
March 13, 2024: Hematology, Transfusion and Cell Therapy
https://read.qxmd.com/read/38521626/consensus-of-the-brazilian-association-of-hematology-hemotherapy-and-cellular-therapy-on-patient-blood-management-assessment-and-management-of-coagulation-in-the-preoperative-period
#4
JOURNAL ARTICLE
Flavia Leite, Bruno Deltreggia Benites, Roberto Luiz da Silva, Selma Soriano, Susankerle de Oliveira Costa Alves, Silvia Renata Cornélio Parolin Rizzo, Guilherme Rabello, Dante Mario Langhi Junior
Managing coagulation disorders and potential bleeding risks, especially in the context of anticoagulant medications, is of immense value both clinically and prior to surgery. Coagulation disorders can lead to bleeding complications, affecting patient safety and surgical outcomes. The use of Patient Blood Management protocols offers a comprehensive, evidence-based approach that effectively addresses these challenges. The problem is to find a delicate balance between preventing thromboembolic events (blood clots) and reducing the risk of bleeding...
March 13, 2024: Hematology, Transfusion and Cell Therapy
https://read.qxmd.com/read/38508946/consensus-of-the-brazilian-association-of-hematology-hemotherapy-and-cellular-therapy-on-patient-blood-management
#5
JOURNAL ARTICLE
Juan Carlos Montano-Pedroso, Silvana Biagini, Maria Cristina Martins de Almeida Macedo, Glaciano Ribeiro, José Franciscos Comenalli Marques Junior, Silvia Renata Cornélio Parolin Rizzo, Guilherme Rabello, Dante Mario Langhi Junior
Patient Blood Management (PBM) is a multidimensional approach that seeks to optimize the use of blood and its components in patients. This matter emerged as a response to the need to reduce unnecessary exposure to blood transfusions and their potential risks. In the past, blood transfusion was often overused resulting in complications and high costs. The advent of Patient Blood Management has caused a paradigm shift, highlighting anemia prevention, bleeding control and maximizing the production of blood cells by the organism itself...
March 11, 2024: Hematology, Transfusion and Cell Therapy
https://read.qxmd.com/read/38326179/consensus-of-the-brazilian-association-of-hematology-hemotherapy-and-cellular-therapy-abhh-and-the-brazilian-ministry-of-health-general-management-of-blood-and-blood-products-on-the-tests-necessary-for-the-release-of-exceptional-medicines-for-sickle-cell-disease
#6
JOURNAL ARTICLE
Clarisse Lobo, Aderson Araújo, Alexandre de Albuquerque Antunes, Ana Cristina Silva Pinto, Ariadne Carvalho Godinho, Cassia Silvestre Mariano Pires, Cinthia Cristina Matheus, Xerez de Albuquerque, Daniele Campos Fontes Neves, Fábio de Lima Moreno, Giorgio Baldanzi, Grazziella Curado Siufi, Heloisa Helena Pereira Miranda, Jane Hankins, Joice Aragão, Josefina Aparecida Pellegrini Braga, Juliana Touguinha Neves Martins, Luciana Campos Costa Machado de Souza, Maria Stella Figueiredo, Mirella Rodrigues Oliveira, Patricia Santos Resende Cardoso, Patricia Costa Alves Pinto, Patricia Gomes Moura, Rodolfo Delfino Cançado, Paulo Ivo Cortez de Araujo, Sara Olalla Saad, Sandra Regina Loggetto, Teresa Cristina Cardoso Fonseca
To date, hydroxyurea is the only effective and safe drug that significantly reduces morbidity and mortality of individuals with Sickle cell disease. Twenty years of real-life experience has demonstrated that hydroxyurea reduces pain attacks, vaso-occlusive events, including acute chest syndrome, the number and duration of hospitalizations and the need for transfusion. The therapeutic success of hydroxyurea is directly linked to access to the drug, the dose used and adherence to treatment which, in part, is correlated to the availability of hydroxyurea...
February 1, 2024: Hematology, Transfusion and Cell Therapy
https://read.qxmd.com/read/38314246/the-ratio-of-intraoperative-red-blood-cell-transfusion-to-blood-loss-associated-with-early-postoperative-complications-in-pediatric-liver-transplantation-patients
#7
JOURNAL ARTICLE
Yiming Ma, Cheng Li, Liying Sun, Xiaofei Li
INTRODUCTION: Liver transplantation (LT) is an operation purposed to save the lives of children with acute or chronic liver diseases, hepatic tumors, and some genetic and metabolic diseases. However, patients who underwent LT have a significant risk of intraoperative blood loss and red blood cell (RBC) transfusion, especially in pediatric patients. METHODS: In this study, 569 pediatric patients (<18 years old) who underwent LT at a tertiary university hospital between 2013 and 2020 were included...
February 2024: Transfusion Medicine and Hemotherapy
https://read.qxmd.com/read/38314245/the-putative-role-of-the-transient-receptor-potential-ion-channel-of-vanilloid-type-2-in-red-blood-cell-storage-lesions
#8
JOURNAL ARTICLE
Nicoletta Murciano, Lars Kaestner
No abstract text is available yet for this article.
February 2024: Transfusion Medicine and Hemotherapy
https://read.qxmd.com/read/38314244/allogeneic-blood-transfusion-and-risk-of-postoperative-complications-in-patients-with-mild-and-moderate-anemia-of-any-cause-a-retrospective-cohort-study-in-total-revision-hip-surgery
#9
JOURNAL ARTICLE
Henning Uden, Franziska Büttner, Christian von Heymann, Michael Krämer, Lutz Kaufner, Gerald Vorderwülbecke, Sebastian Hardt, Jochen Kruppa, Felix Balzer, Claudia Spies
INTRODUCTION: Patients undergoing revision total hip surgery (RTHS) have a high prevalence of mild and moderate preoperative anemia, associated with adverse outcomes. The aim of this study was to investigate the association of perioperative allogeneic blood transfusions (ABT) and postoperative complications in preoperatively mild compared to moderate anemic patients undergoing RTHS who did not receive a diagnostic anemia workup and treatment before surgery. METHODS: We included 1,765 patients between 2007 and 2019 at a university hospital...
February 2024: Transfusion Medicine and Hemotherapy
https://read.qxmd.com/read/38314243/impact-of-additional-administration-of-von-willebrand-factor-concentrates-to-thrombocyte-transfusion-in-perioperative-bleeding-in-cardiac-surgery
#10
JOURNAL ARTICLE
Katrin Ledergerber, Alexa Hollinger, Sibylle Zimmermann, Atanas Todorov, Maren Trutmann, Laura Gallachi, Lena Anna Gschwandtner, Lisa Andrea Ryser, Caroline Eva Gebhard, Daniel Bolliger, Andreas Buser, Dimitrios Athanasios Tsakiris, Martin Siegemund
BACKGROUND: Von Willebrand factor (vWF) is an important part of blood coagulation since it binds platelets to each other and to endothelial cells. In traumatic and surgical haemorrhage, both blood cells and plasmatic factors are consumed, leading to consumption coagulopathy and fluid resuscitation. This often results in large amounts of crystalloids and blood products being infused. Additional administration of vWF complex and platelets might mitigate this problem. We hypothesize that administration of vWF concentrate additionally to platelet concentrates reduces blood loss and the amount of blood products (platelets, red blood cells [RBC], fresh frozen plasma [FFP]) administered...
February 2024: Transfusion Medicine and Hemotherapy
https://read.qxmd.com/read/38314242/validation-of-a-parvovirus-b19-nat-assay-for-screening-of-umbilical-cord-blood-for-allogenic-hematopoietic-stem-cell-donation
#11
JOURNAL ARTICLE
Philipp Steininger, Klaus Korn, Holger Hackstein, Erwin F Strasser
INTRODUCTION: Parvovirus B19 transmitted by umbilical cord blood (UCB) products may cause severe disease in allogenic hematopoietic stem cell transplant recipients. Thus, commercially available nucleic acid test (NAT) assays for highly sensitive detection of parvovirus B19 DNA validated for the specimen cord blood plasma (CBP) are required to avoid parvovirus B19 transmission by umbilical hematopoietic stem cell preparations. METHODS: The multiplex cobas DPX NAT assay was validated for detection of parvovirus B19 DNA in CBP derived from citrate anticoagulated UCB units which have been processed by the Rubinstein method...
February 2024: Transfusion Medicine and Hemotherapy
https://read.qxmd.com/read/38314241/implementation-of-a-bleeding-management-algorithm-in-liver-transplantation-a-pilot-study
#12
JOURNAL ARTICLE
Ignacio A Sarmiento, María F Guzmán, Javier Chapochnick, Jens Meier
OBJECTIVES: The aims of the study were to compare the consumption of blood products before and after the implementation of a bleeding management algorithm in patients undergoing liver transplantation and to determine the feasibility of a multicentre, randomized study. BACKGROUND: Liver transplantation remains the only curative therapy for patients with end-stage liver disease, but it carries a high risk of surgical bleeding. MATERIALS AND METHODS: Retrospective study of patients treated before (group 1) and after (group 2) implementation of a haemostatic algorithm guided by viscoelastic testing, including use of lyophilized coagulation factor concentrates ( prothrombin complex and fibrinogen concentrates )...
February 2024: Transfusion Medicine and Hemotherapy
https://read.qxmd.com/read/38314240/high-throughput-cd36-phenotyping-on-human-platelets-based-on-sandwich-elisa-and-mutant-gene-analysis
#13
JOURNAL ARTICLE
Honghong He, Longhai Tang, Yiming Jin, Yujue Wang, Hongmei Wang, Shaohua Ding, Yezhou Chen, Jingjing Tian, Mingyuan Wang, Shengbao Duan
BACKGROUND: CD36 deficiency is closely associated with fetal/neonatal alloimmune thrombocytopenia, platelet transfusion refractoriness, and other hemorrhage disorders, particularly in Asian and African populations. There is a clinical need for rapid and high-throughput methods of platelet CD36 (pCD36) phenotyping to improve the availability of CD36 typing of donors and assist clinical blood transfusions for patients with anti-CD36 antibodies. Such methods can also support the establishment of databases of pCD36-negative phenotypes...
February 2024: Transfusion Medicine and Hemotherapy
https://read.qxmd.com/read/38314239/quartic-car-t-cell-bridging-to-twice-allo-hsct-therapy-in-a-patient-with-acute-lymphoblastic-leukemia
#14
Qing Zhang, Yi Dong, Zhimin Zhai, Qianshan Tao
INTRODUCTION: Chimeric antigen receptor T (CAR-T) cell therapy is an effective bridging treatment for allogeneic hematopoietic stem cell transplantation (allo-HSCT) in relapsed or refractory acute lymphoblastic leukemia (ALL). However, repetitive CAR-T cell therapy and allo-HSCT can only be performed in a few patients because of technical difficulties and patients' physical, economic, and social conditions. CASE PRESENTATION: A 23-year-old female patient with second relapsed B-cell ALL (B-ALL) underwent human-murine chimeric CD19 CAR-T cell therapy twice, human-murine chimeric CD22 CAR-T cell therapy once, and humanized CD19 CAR-T cell therapy once...
February 2024: Transfusion Medicine and Hemotherapy
https://read.qxmd.com/read/38306192/too-early-to-abandon-convalescent-plasma-for-supportive-treatment-of-covid-19
#15
JOURNAL ARTICLE
Rainer Seitz, Lutz Gürtler, Ute Vahlensieck, Anneliese Hilger, Wolfgang Schramm
No abstract text is available yet for this article.
June 2023: Transfusion Medicine and Hemotherapy
https://read.qxmd.com/read/38089498/patient-blood-management-we-still-have-work-to-do
#16
JOURNAL ARTICLE
Patrick Meybohm, Lotta Hof, Suma Choorapoikayil, Kai Zacharowski
No abstract text is available yet for this article.
December 2023: Transfusion Medicine and Hemotherapy
https://read.qxmd.com/read/38089497/a-german-wide-systematic-study-on-mobilization-and-collection-of-hematopoietic-stem-cells-in-poor-mobilizer-patients-with-multiple-myeloma-prior-to-autologous-stem-cell-transplantation
#17
JOURNAL ARTICLE
Max Bittrich, Katharina Kriegsmann, Carola Tietze-Stolley, Kamran Movassaghi, Matthias Grube, Vladan Vucinic, Daniela Wehler, Andreas Burchert, Martin Schmidt-Hieber, Andreas Rank, Heinz A Dürk, Bernd Metzner, Christoph Kimmich, Marcus Hentrich, Christian Kunz, Frank Hartmann, Cyrus Khandanpour, Maike de Wit, Udo Holtick, Michael Kiehl, Andrea Stoltefuß, Alexander Kiani, Ralph Naumann, Christian W Scholz, Hans-Joachim Tischler, Martin Görner, Franziska Brand, Martin Ehmer, Nicolaus Kröger
INTRODUCTION: In patients with a clinical indication for autologous hematopoietic stem cell transplantation (ASCT), sufficient mobilization of CD34+ precursor cells into peripheral blood is essential to ensure adequate hematopoietic stem cell (HSC) collection prior to intensive therapy. However, with standard granulocyte-colony stimulating factor (G-CSF)-based mobilization schemes, an important minority of patients fail to mobilize sufficient (e.g., >10/µL) CD34+ cell counts into the peripheral blood and are considered as poor mobilizers (PM)...
December 2023: Transfusion Medicine and Hemotherapy
https://read.qxmd.com/read/38089496/the-impact-of-pathogen-reduction-on-total-igg-and-igg-subclass-profiles-of-convalescent-plasma
#18
JOURNAL ARTICLE
Tomasz Wasiluk, Magdalena Sredzinska, Anna Rogowska, Magdalena Dzieniszewska, Agnieszka Zebrowska, Barbara Boczkowska-Radziwon, Katarzyna Gagola, Anna Stasiak-Barmuta, Marcus Picard-Maureau, Piotr Radziwon
INTRODUCTION: In case of newly emerging pathogens, convalescent plasma (CP) is often the only early available treatment option. It has been shown that different IgG subclasses contribute differently to CP neutralizing activity. As CP donors often have a risk profile like first-time donors, especially with respect to window-period viral transmission, pathogen reduction (PR) could mitigate that risk. The aim of our study, especially in the light of potential future pandemics, was to evaluate the impact of commercially available PR technologies on total IgG and IgG subclasses quantity and distribution in CP using COVID-19 CP (CCP) as surrogate for CP in a side-by-side comparison approach...
December 2023: Transfusion Medicine and Hemotherapy
https://read.qxmd.com/read/38089495/challenges-for-plasma-derived-medicinal-products
#19
JOURNAL ARTICLE
Rainer Moog, Teija Dehmer-Laitinen, Uwe Taborski
No abstract text is available yet for this article.
December 2023: Transfusion Medicine and Hemotherapy
https://read.qxmd.com/read/38089494/hla-linked-regional-differences-in-donor-selection-a-9-year-study-of-the-swiss-registry
#20
JOURNAL ARTICLE
Oliver Kürsteiner, Grazia Nicoloso, Tizian Demont, Marcel Büchler, Jean-Marie Tiercy
INTRODUCTION: The large HLA diversity in worldwide populations is a major challenge for matched unrelated haematopoietic stem cell (HSC) donor searches. The impact of regional diversity on the effective HSC donor selection has not been documented so far for national registries. METHODS: The aim of the study was to analyse the 532 consecutive work-up (WU) requests received by Swiss Blood Stem Cells (SBSC), over a 9-year period (2011-2019) with respect to criteria including the geographical origin of the donors as derived from the postal codes, countries requesting SBSC donors, HLA-matching parameters, and patients' HLA haplotype frequencies...
December 2023: Transfusion Medicine and Hemotherapy
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