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still‘s disease

S Florim, A Almeida, D Rocha, P Portugal
Acute mesenteric ischaemia (AMI) is an uncommon cause of acute hospital admission with high mortality rates (50-90%) that requires early diagnosis and treatment. With the increase in average life expectancy, AMI represents one of the most threatening abdominal conditions in elderly patients. Untreated, AMI will cause mesenteric infarction, intestinal necrosis, an overwhelming inflammatory response and death. Early intervention can reverse this process leading to a full recovery, but the diagnosis of AMI is difficult...
August 17, 2018: Insights Into Imaging
Heba Ahmed Osman, Sanaa S Aly, Hasan S Mahmoud, Eman H Ahmed, Eman M Salah Eldin, Eman A Abdelrahim, Muhammad A El Masry, Rania A Herdan, Mohammed H Hassan
BACKGROUND AND AIMS: Gastroesophageal reflux disease (GERD) is a common prevalent disease. We aimed to assess the dynamic changes in the peripheral T lymphocytes and lymphocytes infiltrating the esophageal mucosa after treatment with proton-pump inhibitor (PPI) in patients with GERD. PATIENTS AND METHODS: A total of 200 patients who presented with upper GIT symptoms were included in this prospective study. All patients were subjected to full history taking, clinical examination, and complete blood count...
August 16, 2018: Journal of Clinical Gastroenterology
Jorge M Pinto-Filho, Lívia S F Ribeiro, Luiza Sartori, Jean N Dos Santos, Luciana M P Ramalho, Patricia R Cury
The impact of alcohol consumption on periodontal disease and tooth loss is still under debate. The aim of this cross-sectional study was to evaluate the association between alcohol dependence and both periodontal diseases and tooth loss in Brazilian native Indians. Full mouth periodontal examination was performed and tooth loss was clinically evaluated in a representative sample of 225 Indians (≥ 19 years). Sociodemographic, oral health-related data, and alcohol dependence were evaluated using structured questionnaires...
August 15, 2018: Environmental Science and Pollution Research International
Wail M Hassan, Laila Al-Ayadhi, Geir Bjørklund, Altaf Alabdali, Salvatore Chirumbolo, Afaf El-Ansary
Effective biomarkers are urgently needed to facilitate early diagnosis of autism spectrum disorder (ASD), permitting early intervention, and consequently improving prognosis. In this study, we evaluate the usefulness of nine biomarkers and their association (combination) in predicting ASD onset and development. Data were analyzed using multiple independent mathematical and statistical approaches to verify the suitability of obtained results as predictive parameters. All biomarkers tested appeared useful in predicting ASD, particularly vitamin E, glutathione-S-transferase, and dopamine...
August 15, 2018: Journal of Molecular Neuroscience: MN
D E Meyers, P M Bryan, S Banerji, D G Morris
Lung cancer is the leading cause of cancer-specific death among Canadians, with non-small-cell lung cancer (nsclc) being the most common histologic variant. Despite advances in the understanding of the molecular biology of nsclc, the survival rate for this malignancy is still poor. It is now understood that, to evade detection and immune clearance, nsclc tumours overexpress the immunosuppressive checkpoint protein programmed death ligand 1 (PD-L1). Inhibiting the PD-1/PD-L1 axis with monoclonal antibodies has significantly changed the treatment landscape in nsclc during the last 5 years...
August 2018: Current Oncology
Lucy L Furfaro, Barbara J Chang, Matthew S Payne
SUMMARY Streptococcus agalactiae , or group B streptococcus (GBS), is a major neonatal pathogen. Recent data have elucidated the global prevalence of maternal and neonatal colonization, but gaps still remain in the epidemiology of this species. A number of phenotypic and genotypic classifications can be used to identify the diversity of GBS strains, and some are more discriminatory than others. This review explores the main schemes used for GBS epidemiology and further details the targets for epidemiological surveillance...
October 2018: Clinical Microbiology Reviews
Muhammad Altaf, Muhammad Umair, Abdul Rauf Abbasi, Noor Muhammad, Arshad Mehmood Abbasi
BACKGROUND: Different species of animals are being utilized in traditional therapies by various cultures for a long time and such uses still exist in folk medicine. The present study aimed to document animal-based traditional therapies used by the local communities of Jhelum and Lahore districts of the Punjab province, Pakistan. METHODS: Field surveys were conducted in 2015-2016 in six different sites of the study areas. Data were collected through semi-structured interviews and face to face conversation with local informants...
August 15, 2018: Journal of Ethnobiology and Ethnomedicine
Wichuda Phothichaisri, Puey Ounjai, Tanaporn Phetruen, Tavan Janvilisri, Pongsak Khunrae, Sombat Singhakaew, Piyada Wangroongsarb, Surang Chankhamhaengdecha
Clostridium difficile is recognized as a problematic pathogen, causing severe enteric diseases including antibiotic-associated diarrhea and pseudomembranous colitis. The emergence of antibiotic resistant C. difficile has driven a search for alternative anti-infection modalities. A promising strategy for controlling bacterial infection includes the use of bacteriophages and their gene products. Currently, knowledge of phages active against C. difficile is still relatively limited by the fact that the isolation of phages for this organism is a technically demanding method since bacterial host themselves are difficult to culture...
2018: Frontiers in Microbiology
Silvia R S Ouakinin, David P Barreira, Carlos J Gois
Literature on depression and obesity describes the relevance of the hypothalamic pituitary adrenal axis dysfunction, sympathetic nervous system (SNS) activation, and inflammatory processes as well as the interaction of genetic and environmental factors. Recent investigation in obesity highlights the involvement of several regulation systems, particularly in white adipose tissue. The hypothalamic pituitary adrenal axis, gonadal, growth hormone, leptin, sympathetic nervous system and adrenergic, dopaminergic, and serotoninergic central pathways, all seem interconnected and involved in obesity...
2018: Frontiers in Endocrinology
Cécile Feuillie, Pauline Vitry, Maeve A McAleer, Sanja Kezic, Alan D Irvine, Joan A Geoghegan, Yves F Dufrêne
The bacterial pathogen Staphylococcus aureus plays an important role in atopic dermatitis (AD), a chronic disorder that mostly affects children. Colonization of the skin of AD patients by S. aureus exacerbates the disease, but the molecular determinants of the bacterium-skin adhesive interactions are poorly understood. Specifically, reduced levels of natural moisturizing factor (NMF) in the stratum corneum have been shown to be associated with more severe AD symptoms, but whether this is directly related to S...
August 14, 2018: MBio
Lydie Boussicault, Radhia Kacher, Antonin Lamazière, Peter Vanhoutte, Jocelyne Caboche, Sandrine Betuing, Marie-Claude Potier
Huntington's Disease (HD) is an autosomal dominant neurodegenerative disease caused by abnormal polyglutamine expansion in huntingtin (mHtt) protein leading to degeneration of striatal neurons. Excitotoxicity, consecutive to overstimulation of N-methyl D-aspartate receptors (NMDARs) has a pivotal role in many neurological disorders including HD. Mutant Htt causes enhanced NMDA sensitivity, alteration of NMDAR expression and localization in neurons. Excitotoxic events initiate neuronal death in numerous ways, including activation of apoptotic cascades...
August 11, 2018: Biochimie
Mario I Fernández, Maurizio Brausi, Peter E Clark, Michael S Cookson, H Barton Grossman, Makarand Khochikar, Lambertus A Kiemeney, Bernard Malavaud, Rafael Sanchez-Salas, Mark S Soloway, Robert S Svatek, Raghunandan Vikram, Alina Vrieling, Ashish M Kamat
PURPOSE: To update current recommendations on prevention, screening, diagnosis, and evaluation of bladder cancer (BC) based on a thorough assessment of the most recent literature on these topics. METHODS: A non-systematic review was performed, including articles until June 2017. A variety of original articles, reviews, and editorials were selected according to their epidemiologic, demographic, and clinical relevance. Assessment of the level of evidence and grade of recommendations was performed according to the International Consultation on Urological Diseases grading system...
August 13, 2018: World Journal of Urology
John S Mattick
Transcriptomic studies have demonstrated that the vast majority of the genomes of mammals and other complex organisms is expressed in highly dynamic and cell-specific patterns to produce large numbers of intergenic, antisense and intronic long non-protein-coding RNAs (lncRNAs). Despite well characterized examples, their scaling with developmental complexity, and many demonstrations of their association with cellular processes, development and diseases, lncRNAs are still to be widely accepted as major players in gene regulation...
August 10, 2018: Non-Coding RNA
S Dizon, S Bhat Hoffman
OBJECTIVE: Determine how blood pressure differs in premature infants born small for gestational age (SGA). DESIGN: A retrospective study was conducted on inborn infants 24-32 weeks gestation. Mean arterial blood pressure (MAP) was collected and averaged every 12 h for the first 96 h of life. For each time point, the difference MAP in SGA vs. AGA infants was evaluated with t-testing. Linear mixed-effects modeling was performed to model MAP over time accounting for GA, BW, gender, and SGA status...
July 31, 2018: Journal of Neonatal-perinatal Medicine
Ane S Kværner, Dong Hang, Edward L Giovannucci, Walter C Willett, Andrew T Chan, Mingyang Song
Background: A major pathway through which obesity increases the risk of cardiometabolic diseases and cancer is by inducing hormonal and metabolic abnormalities, including hyperinsulinemia and altered insulin-like growth factor (IGF) signaling. However, little is known about the influence of lifetime adiposity on the relevant biomarkers. Objective: The aim of this study was to examine associations of trajectories of body fatness with plasma biomarker concentrations of the insulin-IGF system in 2 large prospective cohorts of US men and women...
August 1, 2018: American Journal of Clinical Nutrition
Peter J H Jones, Maryam Shamloo, Dylan S MacKay, Todd C Rideout, Semone B Myrie, Jogchum Plat, Jean-Baptiste Roullet, David J Baer, Kara L Calkins, Harry R Davis, P Barton Duell, Henry Ginsberg, Helena Gylling, David Jenkins, Dieter Lütjohann, Mohammad Moghadasian, Robert A Moreau, David Mymin, Richard E Ostlund, Rouyanne T Ras, Javier Ochoa Reparaz, Elke A Trautwein, Stephen Turley, Tim Vanmierlo, Oliver Weingärtner
Current evidence indicates that foods with added plant sterols or stanols can lower serum levels of low-density lipoprotein cholesterol. This review summarizes the recent findings and deliberations of 31 experts in the field who participated in a scientific meeting in Winnipeg, Canada, on the health effects of plant sterols and stanols. Participants discussed issues including, but not limited to, the health benefits of plant sterols and stanols beyond cholesterol lowering, the role of plant sterols and stanols as adjuncts to diet and drugs, and the challenges involved in measuring plant sterols and stanols in biological samples...
August 7, 2018: Nutrition Reviews
Benjamin J DiPardo, Paul Winograd, Colin M Court, James S Tomlinson
Pancreatic cancer (PC) is a highly lethal disease, in part because of early metastasis, late diagnosis, and limited treatment options. Circulating tumor cells (CTCs) are cancer cells that have achieved the metastatic step of intravasation, and are thus a unique source of biomarkers with potential applications in the staging, prognostication, and treatment of PC. Areas covered: This review describes the use of CTCs in PC, including isolation methods, the significance of CTC enumeration, and studies examining phenotypic and molecular characteristics of CTCs...
August 11, 2018: Expert Review of Molecular Diagnostics
A R Rafieerad, A R Bushroa, Ahmad Amiri, K Kalaiselvam, K M Vellasamy, J Vadivelu
Antibacterial ability is vital in biological approaches as well as functional biomaterials. Besides, cytocompatibility aspect of biologic media, tissue and organs is always concern for appropriate synthesis. From the past, metallic/oxide phases of silver (Ag) material in various macro, micro or nano configurations have been widely used for antibacterial targets. While, background of Ag toxicity within particle, film and composites is posing gradual ion release affected by molecular bounding. Recent researches conducted to control, optimize and neutralize Ag limitations finding the benefits of ideal (∼ 100%) mediation against both Gram-negative and Gram-positive bacteria...
July 31, 2018: Journal of Hazardous Materials
Ziyi Li, Chuan Zhou, Ge Chen, Yuhai Bao
BACKGROUND: Rosai-Dorfman disease (RDD), also called sinus histiocytosis with massive lymphadenopathy (SHML), is an idiopathic, non-neoplastic, lymphoproliferative disorder. Histologically, the disease is characterized by emperipolesis and S-100 immunoreactivity. RDD usually presents with massive painless cervical lymphadenopathy, only 5% affecting the central nervous system (CNS). CASE DESCRIPTION: We here report on a 46-year-old female of isolated RDD of the left cavernous sinus with left facial numbness and weakness of left masticatory muscle...
August 9, 2018: World Neurosurgery
Hannah E Walters, Lynne S Cox
Chronological age represents the greatest risk factor for many life-threatening diseases, including neurodegeneration, cancer, and cardiovascular disease; ageing also increases susceptibility to infectious disease. Current efforts to tackle individual diseases may have little impact on the overall healthspan of older individuals, who would still be vulnerable to other age-related pathologies. However, recent progress in ageing research has highlighted the accumulation of senescent cells with chronological age as a probable underlying cause of pathological ageing...
August 8, 2018: International Journal of Molecular Sciences
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