Tien S Dong, Gilbert C Gee, Hiram Beltran-Sanchez, May Wang, Vadim Osadchiy, Lisa A Kilpatrick, Zixi Chen, Vishvak Subramanyam, Yurui Zhang, Yinming Guo, Jennifer S Labus, Bruce Naliboff, Steve Cole, Xiaobei Zhang, Emeran A Mayer, Arpana Gupta
BACKGROUND: Discrimination is associated with negative health outcomes as mediated in part by chronic stress, but a full understanding of the biological pathways is lacking. Here we investigate the effects of discrimination involved in dysregulating the brain-gut microbiome (BGM) system. METHODS: A total of 154 participants underwent brain magnetic resonance imaging to measure functional connectivity. Fecal samples were obtained for 16S ribosomal RNA profiling and fecal metabolites and serum for inflammatory markers, along with questionnaires...
October 28, 2022: Biological Psychiatry