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Lupus OR SLE

François Rodrigues, Claude Bachmeyer
No abstract text is available yet for this article.
December 11, 2018: Rheumatology
Hiroshi Nishi, Tanya N Mayadas
PURPOSE OF REVIEW: Systemic lupus erythematosus (SLE) is a multiorgan autoimmune disease characterized by IgG-autoantibodies to nuclear antigens that can deposit in the kidney and trigger lupus nephritis. Neutrophils accumulate in the kidneys of patients with proliferative LUPUS NEPHRITIS and neutrophil products and a subset of granulocytes, called low-density granulocytes (LDG) may contribute to lupus nephritis pathogenesis. Here, we will discuss recent studies implicating neutrophils in the pathogenesis of human SLE nephritis and then examine studies that provide mechanistic insights into how these cells are recruited to the glomerulus following immune complex deposition and how their products may promote lupus nephritis...
December 11, 2018: Current Opinion in Rheumatology
Eva Schrezenmeier, Sarah Y Weißenberg, Ana-Luisa Stefanski, Franziska Szelinski, Annika Wiedemann, Andreia C Lino, Thomas Dörner
PURPOSE OF REVIEW: This review summarizes recent insights and current understanding of the role of postactivated B cells in SLE and related pathogenic and potential therapeutic implications. RECENT FINDING: B cells are considered key players in SLE and experience from various B-cell-targeted therapies underlines their clinical relevance. In the last years, new insights have been obtained on B-cell abnormality within the complex pathophysiology of SLE. These insights involve a revised understanding of BCR signaling, that has been reported to be hyperresponsive in the past, but newer studies suggest a postactivation functiotype in terms of reduced BCR and TLR signaling...
December 11, 2018: Current Opinion in Rheumatology
Florencia Rosetti, Abigail de la Cruz, José C Crispín
PURPOSE OF REVIEW: The aim of this review is to discuss recent developments in our understanding of how systemic lupus erythematosus (SLE)-associated genes contribute to autoimmunity. RECENT FINDINGS: Gene-function studies have revealed mechanisms through which SLE-associated alleles of IFIH1, TNFAIP3, IRF5, and PRDM1 likely contribute to the development of autoimmunity. Novel research has identified Mac-1 (encoded by ITGAM), CaMK4, and iRhom2 as plausible therapeutic targets in lupus nephritis...
December 11, 2018: Current Opinion in Rheumatology
S C Bae, Y H Lee
OBJECTIVES: This study aimed to examine whether alcohol intake is causally associated with systemic lupus erythematosus (SLE). METHODS: We performed a two-sample Mendelian randomization (MR) analysis using the inverse-variance weighted (IVW), weighted median, and MR-Egger regression methods. We used the publicly available summary statistics of alcohol intake frequency from the UK Biobank genome-wide association studies (GWASs; n = 336,965) as the exposure and an SLE GWAS consisting of 1311 SLE and 1783 control subjects of European descent as the outcome...
December 12, 2018: Lupus
Jorge Moya-Higueras, Andrea Cuevas, Laia Marques-Feixa, Laura Mezquita, María Mayoral, Lourdes Fañanás, Generós Ortet, Manuel I Ibáñez
The main aim of the present study was to develop and validate a checklist for adolescents, the Life Events Inventory for Adolescents (LEIA), for screening stressful life events (SLEs) of different nature (major-minor, dependent-independent, and personal-interpersonal). The LEIA was administered together with another SLE checklist (Escala de Acontecimientos Vitales [Life Events Scale], EAV), and with measures of life satisfaction and externalizing and internalizing symptoms. The results showed that the kappa and the percentage agreement reliability indices were adequate...
December 12, 2018: Assessment
Remi Noe, Sophie Chauvet, Shambhuprasad K Togarsimalemath, Maria Chiara Marinozzi, Maria Radanova, Vasil V Vasilev, Veronique Fremeaux-Bacchi, Marie-Agnes Dragon-Durey, Lubka T Roumenina
The innate immune complement system is a powerful defense cascade against pathogens, but can induce host tissue damage when overactivated. In pathological conditions, mainly but not restricted to renal diseases, such as lupus nephritis, atypical hemolytic uremic syndrome, and C3 glomerulopathies, complement is overactivated or dysregulated by autoantibodies directed against its components and regulators. Among the key autoantibody targets are the initiator of the classical complement pathway C1q, the alternative pathway regulator Factor H, the components of the alternative pathway C3 convertase complex C3 and Factor B and the convertase complex itself...
2019: Methods in Molecular Biology
Qiu-Yu Li, Hai-Yun Li
Biosensors based on the principle of surface plasmon resonance (SPR) are surface-sensitive optical devices used for monitoring biomolecular interactions at the sensor surface in real time without any labeling. It is used in a wide variety of areas including proteomics, clinical diagnosis, environmental monitoring, drug discovery, and food analysis. C-reactive protein (CRP) is a marker of inflammation, which undergoes conformation changes in local lesions, leading to the formation of mCRP. Autoantibodies against mCRP are frequently detected in systemic lupus erythematosus (SLE) and associated with disease activity and prognosis...
2019: Methods in Molecular Biology
Anci Verlemyr, Lennart Truedsson, Lillemor Skattum
Anti-C1q autoantibodies may be found in many conditions, most commonly in systemic lupus erythematosus (SLE) and hypocomplementemic urticarial vasculitis syndrome (HUVS), and are diagnostic markers as well as disease activity markers in lupus nephritis. Sera from patients with SLE and HUVS show partly distinct autoantibody reactivities to separated protein chains B and C of the first component of complement, C1q. These different binding specificities can be detected by Western blot analysis of the autoantibodies under reducing conditions...
2019: Methods in Molecular Biology
Jacqueline Keyhani, Ezzatollah Keyhani
Although the presence of antibodies against double-stranded (ds) DNA is considered the serological hallmark of systemic lupus erythematosus (SLE), it is not detected in all SLE patients by routine laboratory tests. Looking at DNA-anti(ds)DNA interaction as one kind of DNA-protein interaction gave us the grounds for a novel type of assay, easy to perform, and providing a direct insight on DNA-anti(ds)DNA IgG interaction. The assay is an application of the electrophoretic mobility shift assay (EMSA) and is based on the observation that the electrophoretic mobility of a DNA-protein complex is typically less than that of free DNA...
2019: Methods in Molecular Biology
Paola A Zeña-Huancas, Haydee Iparraguirre-López, Rocío V Gamboa-Cárdenas, Cristina Reátegui-Sokolova, Francisco Zevallos-Miranda, Mariela Medina-Chinchon, Victor R Pimentel-Quiroz, Claudia Elera-Fitzcarrald, Omar Sarmiento-Velasquez, Jorge M Cucho-Venegas, José L Alfaro-Lozano, Zoila J Rodríguez-Bellido, César A Pastor-Asurza, Risto A Perich-Campos, Graciela S Alarcón, Manuel F Ugarte-Gil
OBJECTIVE: To determine the impact of homocysteine levels on damage accrual in systemic lupus erythematosus (SLE) patients. METHODS: This longitudinal study was conducted in consecutive patients seen every 6 months at our Rheumatology Department since 2012. Patients with available homocysteine levels and who had at least one subsequent visit were included. Univariable and multivariable Cox regression models were done to determine if homocysteine levels were predictive of damage accrual as per the SLICC Damage Index (SDI)...
December 12, 2018: Clinical Rheumatology
Justin A Dellinger, Carolyn R Shores, Apryle Craig, Michael R Heithaus, William J Ripple, Aaron J Wirsing
The non-consumptive effects of predators on prey are now widely recognized, but the need remains for studies identifying the factors that determine how particular prey species respond behaviorally when threatened with predation. We took advantage of ongoing gray wolf (Canis lupus) recolonization in eastern Washington, USA, to contrast habitat use of two sympatric prey species-mule (Odocoileus hemionus) and white-tailed (O. virginianus) deer-at sites with and without established wolf packs. Under the hypothesis that the nature and scale of responses by these ungulates to wolf predation risk depend on their divergent flight tactics (i...
December 11, 2018: Oecologia
Grigorios Theodosiou, Marina Papageorgiou, Ioanna Mandekou-Lefaki
We report a case report of lupus vulgaris (LV) presented on the extremities of an 80-year-old man. He was misdiagnosed as having psoriasis and referred to our department for a second-opinion evaluation. The discrepancy between the clinical manifestation which was misleading and the dermatoscopic findings raised the suspicion of an underlying granulomatous disease and we proceeded to skin biopsy. The histopathologic examination set the diagnosis of LV.
2018: Case Reports in Dermatological Medicine
Alba Santos, Gilbert Greub, Sébastien Aeby, Dorothea Wunder, Giuseppe Pantaleo, Camillo Ribi
Background: SLE is an autoimmune condition affecting predominantly women. Little is known regarding Chlamydia trachomatis infection in women with SLE, which may drive autoimmunity and contribute to obstetrical and vascular complications. Methods: This single-centre, case-control study set primary endpoint in the comparative seropositivity rate to C. trachomatis major outer membrane protein (MOMP) and chlamydial heat-shock protein-60 (cHSP60) in age-matched subjects...
2018: Lupus Science & Medicine
Ioanna Giannakou, Katerina Chatzidionysiou, Laurence S Magder, Noemi Györi, Ronald van Vollenhoven, Michelle A Petri
Objectives: The aim of this study is to identify prognostic factors of persistent disease activity and long quiescence in systemic lupus erythematosus (SLE). Methods: Patients enrolled in the Hopkins Lupus Cohort from 1987 to 2012, who attended at least three visits per year during 3 consecutive years following baseline and had available information on disease activity were included. Patterns of SLE disease activity over the 3-year period were defined as: persistent long quiescent (pLQ), persistent relapsing-remitting (pRR), persistent chronic active (pCA) and mixed based on Modified SLE Disease Activity Index (M-SLEDAI)...
2018: Lupus Science & Medicine
Kerry A Casey, Xiang Guo, Michael A Smith, Shiliang Wang, Dominic Sinibaldi, Miguel A Sanjuan, Liangwei Wang, Gabor G Illei, Wendy I White
Objective: Anifrolumab is a fully human immunoglobulin G1 κ monoclonal antibody specific for subunit 1 of the type I interferon (IFN) α receptor. In a phase IIb study of adults with moderate to severe SLE, anifrolumab treatment demonstrated substantial reductions in multiple clinical endpoints. Here, we evaluated serum proteins and immune cells associated with SLE pathogenesis, type I interferon gene signature (IFNGS) test status and disease activity, and how anifrolumab affected these components...
2018: Lupus Science & Medicine
Ashwaq AlE'ed, Pinar Ozge Avar Aydin, Nora Al Mutairi, Alhanouf AlSaleem, Hafize Emine Sonmez, Michael Henrickson, Jennifer L Huggins, Seza Ozen, Sulaiman M Al-Mayouf, Hermine I Brunner
Objective: To determine the measurement properties of the Cutaneous Lupus Erythematosus Disease Area and Severity Index (CLASI) and the paediatric adaptation of the Skindex29 (pSkindex27) when used in childhood-onset SLE (cSLE). Methods: Patients with mucocutaneous involvement of cSLE were evaluated at the study entry and 6 months later. Besides the CLASI and pSkindex27, the Pediatric Quality of Life Inventory Generic Core scale (PedsQL-GC), its Rheumatology Module (PedsQL-RM), the SLE Disease Activity Index (SLEDAI) and the SLE Damage Index (SDI) were completed...
2018: Lupus Science & Medicine
Chiara Tani, Elena Elefante, Miguel Martin-Cascón, Meriem Belhocine, Cristina Lavilla Olleros, Roberta Vagelli, Chiara Stagnaro, Nathalie Costedoat-Chalumeau, Guillermo Ruiz-Irastorza, Marta Mosca
Objectives: To analyse the real-life practice on the use of Tacrolimus (TAC) in patients with systemic lupus erythematosus (SLE) from three European SLE referral centres. Methods: Adult patients with SLE regularly followed at three European referral centres were included. Demographics, cumulative organ involvement, treatment history, Systemic Lupus Disease Activity Index (SLEDAI), laboratory features and physician's judgement were collected at baseline and at 3-6-12 months after starting TAC...
2018: Lupus Science & Medicine
Sahena Haque, Sarah Skeoch, Chadi Rakieh, Helena Edlin, Yasmeen Ahmad, Pauline Ho, Rachel Gorodkin, M Yvonne Alexander, Ian N Bruce
Objectives: We aimed to describe the rate and determinants of carotid plaque progression and the onset of clinical cardiovascular disease (CVD) in a UK SLE cohort. Methods: Female patients with SLE of white British ancestry were recruited from clinics in the North-West of England and had a baseline clinical and CVD risk assessment including measurement of carotid intima-media thickness (CIMT) and plaque using B-mode Doppler ultrasound. Patients were followed up (>3...
2018: Lupus Science & Medicine
Hamdy Ma Ahmed, Samar Abohamad, Mohanad Elfishawi, Mohamed Tharwat Hegazy, Kadambari Vijaykumar
Belimumab is a novel add-on therapy that has been approved for patients with active and antibody-mediated systemic lupus erythematosus. It is a monoclonal antibody that decreases the activation of B-cells and consequently decreases antibodies' production. Recently, the US Food and Drug Administration approved subcutaneous belimumab for patients who have received training on using it. Subcutaneous belimumab can be administered using either a prefilled syringe or an auto-injector device. Weekly subcutaneous belimumab seems to be as effective as monthly intravenous belimumab with a similar safety margin...
2018: Patient Preference and Adherence
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