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Lupus OR SLE

Alexia D'Andréa, Damien L Peillet, Christine Serratrice, Pierre-Augute Petignat, Virginie Prendki, Jean-Luc Reny, Jacques Serratrice
RATIONALE: Eosinophilic pleural effusion in elderly patients is most commonly due to malignancies and infections. PATIENT CONCERNS: In rare cases, pleural eosinophilia is associated with connective tissue disease. DIAGNOSES: Presence of Hargraves cells, also called lupus erythematosus (LE) cells (polynuclear cells that have engulfed denatured nuclear material), was a key point of American College of Rheumatology (ACR) classification criteria for systemic lupus erythematosus (SLE) until 1997...
October 2018: Medicine (Baltimore)
Wan Syamimee Wan Ghazali, Saidatul Manera Mohd Daud, Nurashikin Mohammad, Kah Keng Wong
The aims of this study were to determine damage index in systemic lupus erythematosus (SLE) patients based on Systemic Lupus International Collaborating Clinics/American College of Rheumatology (SLICC/ACR) Damage Index (SDI) and to determine the laboratory and clinico-demographic factors affecting SDI.This is a retrospective cohort study of 94 SLE patients attending rheumatology clinics in 2 local hospitals in Kelantan, Malaysia. The patients were divided into 2 groups based on SDI score assigned by the attending physician, 0 (without damage) or ≥1 (with damage)...
October 2018: Medicine (Baltimore)
Takeshi Tsubata
B cells express various inhibitory co-receptors including CD22, CD72, and Siglec-G. These receptors contain immunoreceptor tyrosine-based inhibition motifs (ITIMs) in the cytoplasmic region. Although many of the inhibitory co-receptors negatively regulate BCR signaling by activating SH2-containing protein tyrosine phosphatase 1 (SHP-1), different inhibitory co-receptors have distinct functional properties. CD22, Siglec-G, and CD72 preferentially regulate tonic signaling in conventional B cells, B-1 cell homeostasis, and development of lupus-like disease, respectively...
2018: Frontiers in Immunology
Andrew P Ferretti, Rhea Bhargava, Shani Dahan, Maria G Tsokos, George C Tsokos
Calcium calmodulin kinase IV (CaMK4) regulates multiple processes that significantly contribute to the lupus-related pathology by controlling the production of IL-2 and IL-17 by T cells, the proliferation of mesangial cells, and the function and structure of podocytes. CaMK4 is also upregulated in podocytes from patients with focal segmental glomerulosclerosis (FSGS). In both immune and non-immune podocytopathies, CaMK4 disrupts the structure and function of podocytes. In lupus-prone mice, targeted delivery of a CaMK4 inhibitor to CD4+ T cells suppresses both autoimmunity and the development of nephritis...
2018: Frontiers in Immunology
Josephine Nehring, Lucia A Schirmbeck, Justa Friebus-Kardash, Denise Dubler, Uyen Huynh-Do, Carlo Chizzolini, Camillo Ribi, Marten Trendelenburg
Objectives: Autoantibodies and aberrant immune complexes are pathological hallmarks of systemic lupus erythematosus (SLE). This study aimed to determine the occurrence of IgG autoantibodies against human serum albumin (anti-HSA IgG) and their potential association with antibodies against bovine serum albumin (anti-BSA IgG) in patients with SLE. Methods: Sera of 180 SLE patients included to the Swiss SLE Cohort Study and 188 age- and sex-matched healthy controls were evaluated. Levels of anti-HSA IgG and anti-BSA IgG were quantified by ELISA...
2018: Frontiers in Immunology
Mayu Yagita, Saori Hata, Hiromi Miyata, Hiroko Kakita, Tatsuo Tsukamoto, Eri Muso, Masaaki Fujita
Systemic lupus erythematosus may be associated with various types of malignancy. However, systemic lupus erythematosus occurring with ovarian cancer seems rare, and reliable therapeutic approaches for such cases have yet to be identified. We herein report a case of systemic lupus erythematosus with ovarian cancer that was successfully treated with corticosteroid, plasmapheresis and chemotherapy. This case may provide new insights into treatment approaches for systemic lupus erythematosus with ovarian cancer...
October 17, 2018: Internal Medicine
Wei Wei, Syed Sayeed Ahmad, Shuang Chi, Yu Xie, Mohammad Amjad Kamal, Jiang Li
Sjogren's Syndrome (SS) is a chronic, female overwhelming fundamental issue of an immune system rheumatic sickness that influences the whole body. It is described by lymphocytic invasion of the exocrine viz. salivary and lacrimal glands and by surprising B-cell hyperactivity. Keratoconjunctivitis sicca (dry eye) and Stomatitis sicca (oral dryness) is the primary visual appearance of SS. The primary SS is recognized from secondary SS which happens as a piece of other immune system maladies. The secondary SS exists together particularly with fundamental lupus erythematosus (15- 36%), rheumatoid joint inflammation (20- 32%) and also restricted and progressive systemic sclerosis (11- 24%), less as often as possible with different sclerosis and immune system hepatitis and thyreoiditis...
October 16, 2018: Current Pharmaceutical Design
Mary K Crow, Mikhail Olferiev, Kyriakos A Kirou
Type I interferons, which make up the first cytokine family to be described and are the essential mediators of antivirus host defense, have emerged as central elements in the immunopathology of systemic autoimmune diseases, with systemic lupus erythematosus as the prototype. Lessons from investigation of interferon regulation following virus infection can be applied to lupus, with the conclusion that sustained production of type I interferon shifts nearly all components of the immune system toward pathologic functions that result in tissue damage and disease...
October 17, 2018: Annual Review of Pathology
Grace S Pham, Lei A Wang, Keisa W Mathis
Recent evidence suggests hypertension may be secondary to chronic inflammation that results from hypoactive neuro-immune regulatory mechanisms. To further understand this association, we used systemic lupus erythematosus (SLE) as a model of inflammation-induced hypertension. In addition to prevalent inflammatory kidney disease and hypertension, SLE patients suffer from dysautonomia in the form of decreased efferent vagal tone. Based on this, the cholinergic anti-inflammatory pathway, an endogenous vagus-to-spleen mechanism that when activated results in decreases in systemic inflammation, may be compromised in SLE...
October 17, 2018: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
Andrew M Borman, Adrien Szekely, Mark Fraser, Simon Lovegrove, Elizabeth M Johnson
A novel dermatophyte was isolated from skin scales of a female patient presenting with tinea corporis of the wrist and arm. Her principal risk factor was long-term corticosteroid use for underlying Lupus autoimmune syndrome. Microscopic examination of skin scales from lesions revealed hyphae consistent with dermatophyte infection, and a morphologically identical fungus grew in pure culture on all cultures of skin scales. Repeat isolation of the same organism from persistent lesions five months later confirmed the novel species as the causative agent...
October 16, 2018: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
Eugenia Enriquez Merayo, Savino Sciascia, Dario Roccatello, Maria J Cuadrado
No abstract text is available yet for this article.
October 17, 2018: Expert Review of Clinical Immunology
Ciril Khorolsky, Andrew Castellano, David Comstock, Nooshin K Brinster, Sein Y See, Bruce F Garner
Systemic lupus erythematosus (SLE) and antineutrophil cytoplasmic antibody-associated vasculitis (AAV) overlap syndrome is an inflammatory disorder with a mixed presentation that is characterized by clinical features of both SLE and AAV. Although renal disease predominates, any organ system in the body may be affected. Neurologic manifestation in patients with SLE-AAV overlap syndrome is rare and has only been previously documented as cerebral ischemia. We report a patient with SLE-AAV overlap syndrome diagnosed based on clinical, serologic and biopsy-proven histologic findings who presented with subarachnoid hemorrhage (SAH) secondary to ruptured right anterior cerebral artery aneurysm...
October 16, 2018: Rheumatology International
Kathrine Balslev Skovmøller, Anette Bygum
Drug-induced subacute cutaneous lupus erythematosus (DI-SCLE) is defined as an adverse reaction to continuous use of a culprit drug. The reaction resolves upon drug withdrawal. More than 50 drugs have been linked to DI-SCLE, and it is estimated, that around 20% of the SCLE cases are drug-induced. There are no diagnostic criteria, yet detection of anti-Ro/SSA antibodies combined with erosive/bullous or erythema multiforme/toxic epidermal necrolysis-like lesions, and widespread skin rash seem to be indicative of DI-SCLE...
October 8, 2018: Ugeskrift for Laeger
Bethany J Wolf, Paula S Ramos, J Madison Hyer, Viswanathan Ramakrishnan, Gary S Gilkeson, Gary Hardiman, Paul J Nietert, Diane L Kamen
Development and progression of many human diseases, such as systemic lupus erythematosus (SLE), are hypothesized to result from interactions between genetic and environmental factors. Current approaches to identify and evaluate interactions are limited, most often focusing on main effects and two-way interactions. While higher order interactions associated with disease are documented, they are difficult to detect since expanding the search space to all possible interactions of p predictors means evaluating 2 p - 1 terms...
October 15, 2018: Genes
Sophie Bourgeois, Anja Van den Eeckhaut, Frank De Geeter
We describe the F-FDG PET/CT findings in a rare case of mesenteric panniculitis caused by systemic lupus. A previous CT had raised suspicion of a space-occupying lesion in the left hypochondrium in a context of aspecific constitutional symptoms and inflammatory parameters. The diagnosis of panniculitis was confirmed at laparoscopic biopsy directed by the PET findings. Follow-up F-FDG PET/CT after 1 month of corticosteroid therapy showed complete disappearance of the abdominal hypermetabolic foci.
October 15, 2018: Clinical Nuclear Medicine
Vikas Kailashiya, Usha Singh, Ranjan Rana, Nand Kumar Singh, Debabrata Dash, Jyotsna Kailashiya
PURPOSE: Impairment in number and functions of regulatory T cells (Treg) has been found to be associated with many autoimmune diseases including systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). This study was conducted to identify and compare Treg by flow cytometry using two different staining approaches. METHODS: Treg were identified by using CD4+CD25+high and CD4+CD25+CD127dim staining approaches in SLE and RA patients and healthy controls. Association of both identified Treg levels with various serum markers and clinical presentation was also examined...
October 16, 2018: Immunological Investigations
Daniel S Tylee, Jiayin Sun, Jonathan L Hess, Muhammad A Tahir, Esha Sharma, Rainer Malik, Bradford B Worrall, Andrew J Levine, Jeremy J Martinson, Sergey Nejentsev, Doug Speed, Annegret Fischer, Eric Mick, Brian R Walker, Andrew Crawford, Struan F A Grant, Constantin Polychronakos, Jonathan P Bradfield, Patrick M A Sleiman, Hakon Hakonarson, Eva Ellinghaus, James T Elder, Lam C Tsoi, Richard C Trembath, Jonathan N Barker, Andre Franke, Abbas Dehghan, Stephen V Faraone, Stephen J Glatt
Individuals with psychiatric disorders have elevated rates of autoimmune comorbidity and altered immune signaling. It is unclear whether these altered immunological states have a shared genetic basis with those psychiatric disorders. The present study sought to use existing summary-level data from previous genome-wide association studies to determine if commonly varying single nucleotide polymorphisms are shared between psychiatric and immune-related phenotypes. We estimated heritability and examined pair-wise genetic correlations using the linkage disequilibrium score regression (LDSC) and heritability estimation from summary statistics methods...
October 16, 2018: American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics
Yuta Yoshii, Shinsuke Matsuo, Aya Nishizawa, Takahiro Satoh
No abstract text is available yet for this article.
October 15, 2018: European Journal of Dermatology: EJD
Maryam Sahebari, Zahra Rezaieyazdi, Mandana Khodashahi
BACKGROUND: Selenium is an essential trace element with fundamental effects on human biology. Trace elements deficiency is not an uncommon finding in autoimmune diseases. This deficiency may be a consequence of autoimmune diseases or may contribute to their etiology. With regard to evidence showing the association between selenium deficiency and generation of reactive oxygen species and subsequent inflammation, reviewing the role of selenium in collagen vascular diseases could help researchers to devise strategies for managing these diseases...
October 16, 2018: Current Rheumatology Reviews
Ana Isabel Ospina-Caicedo, Alex Darío Cardona-Rincon, Juan Manuel Bello-Gualtero, Rafael Valle-Onate, Consuelo Romero-Sanchez, P Chalem-Choueka Philippe, Gloria Vasquez Duque
BACKGROUND: Systemic Lupus Erythematosus [SLE] involves genetic, environmental, and hormonal alterations, including Vitamin D deficiency. OBJECTIVE: To evaluate the association between vitamin D levels with anti-dsDNA, complement proteins, immunoglobulins levels and disease activity scores Methods: A cross-sectional study was performed. The levels of 25-OH vitamin D were measured in patients older than 18 years with SLE according to ACR/97 [American College of Rheumatology 1997] from 2013 to 2015...
October 15, 2018: Current Rheumatology Reviews
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