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Lupus OR SLE

Dorothee Kübel, Maximilian Tiller, Tobias Mühling, Maximilian Sohn, Inka Vallbracht, Birgit Waschulzik, Wolfgang Schepp, Felix Gundling
INTRODUCTION:  Systemic lupus erythematodes (SLE) represents an autoimmune disease with a highly variable clinical course affecting numerous organs. Hepatic manifestation seems to be rare. It is not clear whether hepatic disease in SLE is of any prognostic importance or whether it correlates with disease activity. METHODS:  Our patient cohort included 172 patients with proven SLE, all treated at Bogenhausen Hospital between 01.2009 and 12.2015. Retrospectively, all admissions as inpatients and outpatients were analyzed (n = 671; mean 3...
August 13, 2018: Zeitschrift Für Gastroenterologie
Megha Garg, Naaima Mufti, Tara Palmore, Sarfaraz Hasni
Patients with Systemic Lupus Erythematosus (SLE) pose a unique dilemma pertaining to immunization against common pathogens. SLE patients are usually not immunized with vaccines based on the fear of either precipitating infection in this immunosuppressed patient population (with live vaccines) or aggravating autoimmunity and hence lupus flares (with any vaccines). However, elevated vulnerability to infection makes patients with SLE precisely the population that needs protection from vaccine-preventable diseases...
August 10, 2018: Autoimmunity Reviews
Konstantia Psianou, Ioannis Panagoulias, Anastasios D Papanastasiou, Anne-Lise de Lastic, Maria Rodi, Panagiota I Spantidea, Søren E Degn, Panagiotis Georgiou, Athanasia Mouzaki
Sjögren's syndrome (SS) is a chronic autoimmune disease that primarily affects the exocrine glands, resulting in their functional impairment. In SS, lymphocytic infiltration of salivary and lacrimal glands, and deposition of several types of autoantibodies, mainly anti-SS-A (anti-Ro) and anti-SS-B (anti-La), lead to chronic inflammation, with xerostomia and keratoconjunctivitis sicca. In its primary form (pSS), SS does not involve additional connective tissue diseases, whereas in its secondary and more common form (sSS), SS presents in association with other rheumatic autoimmune diseases, mainly rheumatoid arthritis (RA), systemic lupus erythematosus (SLE) and systemic sclerosis (SSc)...
August 10, 2018: Autoimmunity Reviews
Bibiana Sgorla de Almeida, Yara Costa Netto Muniz, Alice Heidrich Prompt, Erick C Castelli, Celso Teixeira Mendes-Junior, Eduardo Antonio Donadi
BACKGROUND: HLA-G is an immune checkpoint molecule. Since a differential molecule expression has been reported even for healthy individuals, many studies have focused on polymorphisms at HLA-G regulatory regions, particularly the 3' untranslated region (3'UTR). The presence/absence of a 14-bp sequence was the first polymorphism described and it is the most studied in association between HLA-G and disorders. METHODS: In this study, we performed a systematic review and meta-analysis of all association studies published regarding the HLA-G 14-bp...
August 10, 2018: Human Immunology
Evrydiki Kravvariti, George Konstantonis, Petros P Sfikakis, Maria G Tektonidou
Objectives: The progression of subclinical atherosclerosis in SLE and RA has not been comparatively assessed. We sought to investigate the impact of low disease activity and other disease-related factors on atherosclerosis progression in SLE vs RA. Methods: We performed a 3-year follow-up carotid and femoral artery ultrasound in 101 patients with SLE, 85 with RA and 85 controls after a baseline examination in 115 SLE and 1:1 age- and gender-matched RA patients and controls...
August 8, 2018: Rheumatology
Matthias F Froelich, Sebastian Stintzing, Jörg Kumbrink, Thomas G P Grünewald, Ulrich Mansmann, Volker Heinemann, Thomas Kirchner, Andreas Jung
Skin toxicity (ST) is a frequent adverse effect (AE) in anti-epidermal growth factor receptor (EGFR)-targeted treatment of metastatic colorectal cancer (mCRC) resulting in decreased quality of life and problems in clinical management. We wanted to identify biomarkers predicting ST in this setting and focused on 70 DNA polymorphisms associated with acne, the (immunoglobulin fragment crystallizable region) Fcγ-receptor pathway, and systemic lupus erythematosus (SLE) applying next-generation-sequencing (NGS)...
July 13, 2018: Oncotarget
Angela Richard-Eaglin, Benjamin A Smallheer
Autoimmune disorders are a category of diseases in which the immune system attacks healthy cells as a result of a dysfunction of the acquired immune system. Clinical presentation and diagnosis are disease specific and often correspond with the degree of inflammation, as well as the systems involved. Treatment varies based on the specific disease, its stage of presentation, and patient symptoms. The primary goal of treatment is to decrease inflammation, minimize symptoms, and lessen the potential for relapse...
September 2018: Nursing Clinics of North America
A Gupta, A Sharma, R K Pilania, D Suri
No abstract text is available yet for this article.
August 12, 2018: Lupus
P D Sattwika, R Mustafa, A Paramaiswari, E H Herningtyas
Lupus nephritis (LN), a common manifestation of systemic lupus erythematosus (SLE), accounts for significant morbidity and mortality in SLE patients. Since the available standard therapies and biologic agents for LN are yet to achieve the desired response and have considerable secondary effects, stem cell therapy has now emerged as a new approach. This therapy involves the transplantation of hematopoietic stem cells (HSCs) and mesenchymal stem cells (MSCs). Our current review will highlight the progress of stem cell therapy for LN, along with the challenges encountered and the future direction of this approach...
August 12, 2018: Lupus
C S A Monção, L N Martins, M P S Penteado, R C P Reis, F M M Santos, C C D Lanna, A L Ribeiro, R W Telles
Objectives To evaluate the incidence and variability of traditional coronary artery disease (CAD) risk factors in a cohort of lupus patients and to investigate if prednisone use predicts an increase in the number of risk factors. Methods A total of 151 women, 37.8 ± 11.1 (mean ± SD) years old at baseline, were reevaluated after a median period of 39 (interquartile range 36.5-42.0) months. The cumulative incidence of traditional risk factors, the incidence rate (with 95% confidence interval) of hypertension, diabetes, dyslipidemia and hypertriglyceridemia, and the frequency of the risk factors' disappearance were calculated...
August 12, 2018: Lupus
Polona Žigon, Anuška Podovšovnik, Aleš Ambrožič, Matija Tomšič, Alojzija Hočevar, Nataša Gašperšič, Žiga Rotar, Sonja Praprotnik, Snežna Sodin Šemrl, Saša Čučnik
The international classification criteria for definite antiphospholipid syndrome (APS) include three laboratory measurements: lupus anticoagulant (LA), IgG and IgM isotypes of anti-cardiolipin (aCL) and anti-β2glycoprotein I antibodies (anti-β2GPI). When persistently elevated, they are specific for APS; however, many patients that fulfil clinical criteria may exhibit negative serological results. These "seronegative" APS (SN-APS) are exposed to an increased thrombotic risk. The aims of our cross-sectional, retrospective study of consecutive autoimmune patients' samples were to evaluate the association of non-criteria antiphospholipid antibodies (aPL) with thrombosis and obstetric events, to calculate the risk score for adverse events and to assess the specific contribution of single aPL positivity in SN-APS...
August 11, 2018: Clinical Rheumatology
Rakesh Kumar Pilania, Deepti Suri, Ankur Kumar Jindal, Narender Kumar, Avinash Sharma, Praveen Sharma, Sandesh Guleria, Amit Rawat, Jasmina Ahluwalia, Surjit Singh
We report two children with systemic lupus erythematosus (SLE) having severe bleeding manifestations and lupus anticoagulant hypoprothrombinemia syndrome (LAHPS) along with a review of published cases of childhood SLE and LAHPS. We report clinical and laboratory profile of two children diagnosed with childhood SLE and LAHPS. We also conducted literature search to identify similar published cases and a review was performed. An 8-year-old girl had presented with fever, arthralgia, alopecia, anasarca and bleeding from multiple sites...
August 11, 2018: Rheumatology International
Durga Chougule, Milind Nadkar, Krishnamurthy Venkataraman, Anjali Rajadhyaksha, Niwrutti Hase, Tukaram Jamale, Seema Kini, Prasad Khadilkar, Vidya Anand, Manisha Madkaikar, Vandana Pradhan
BACKGROUND: Adipokines are chemical mediators released from adipose tissue involved in regulation of appetite, insulin sensitivity, immune system and inflammatory responses. Adipokines contributes to low grade inflammatory response in autoimmune disease like Systemic Lupus Erythematosus (SLE) but the pathophysiology is yet not clear. The aim of this study is to understand role of adipokine interactions in SLE disease pathogenesis. METHODS: Sixty newly diagnosed treatment naïve SLE patients fulfilling the ACR criteria and forty age-sex matched healthy subjects were enrolled in thiscase-control study...
August 8, 2018: Cytokine
C Pindado-Ortega, A Alegre-Sánchez, B Pérez-García, P Boixeda
We read with great interest the guideline for the treatment of cutaneous lupus erythematosus (CLE) elaborated by the European Dermatology Forum in cooperation with the European Academy of Dermatology and Venereology published in the Journal of the European Academy of Dermatology and Venereology in March 2017. A therapeutic guide for CLE is absolutely necessary to decide the best management of our patients. Nevertheless, we would like to point out important aspects regarding the role of laser therapy in patients with CLE...
August 11, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
Annegret Kuhn, Miroslav Skrobal, Beatrix Volc-Platzer
We thank Pindado-Ortega and colleagues for their valuable comments on the use of pulsed-dye laser (PDL) on active lesions of cutaneous lupus erythematosus (CLE) (1). The effectiveness of PDL has been documented in several small case series and case reports, using different laser parameters with and without systemic treatment, some of them performed as prospective studies with a clearance rate up to 70% (2-5). In a systematic review, Erceg et al. concluded a level of evidence C for PDL treatment on CLE (6)...
August 11, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
Manuel Martínez-Bueno, Nina Oparina, Mikhail G Dozmorov, Miranda C Marion, Mary E Comeau, Gary Gilkeson, Diane Kamen, Michael Weisman, Jane Salmon, Joseph W McCune, John B Harley, Robert Kimberly, Judith A James, Joan Merrill, Courtney Montgomery, Carl D Langefeld, Marta E Alarcón-Riquelme
BANK1 is a susceptibility gene for several systemic autoimmune diseases in several populations. Using the genome-wide association study (GWAS) data from Europeans (EUR) and African Americans (AA), we performed an extensive fine mapping of ankyrin repeats 1 ( BANK1 ). To increase the SNP density, we used imputation followed by univariate and conditional analysis, combined with a haplotypic and expression quantitative trait locus (eQTL) analysis. The data from Europeans showed that the associated region was restricted to a minimal and dependent set of SNPs covering introns two and three, and exon two...
August 8, 2018: International Journal of Molecular Sciences
Tamieka A Fraser, Roz Holme, Alynn Martin, Pam Whiteley, Merridy Montarello, Cam Raw, Scott Carver, Adam Polkinghorne
The invasive ectoparasite Sarcoptes scabiei affects the welfare and conservation of Australian marsupials. Molecular data suggest that spillover from other hosts may be responsible for the emergence of this infectious disease, but the scale of such studies is limited. We performed expanded molecular typing of the S. scabiei mitochondrial cox1 gene from 81 skin scrapings from infested wombats ( Vombatus ursinus), koalas ( Phascolarctos cinereus), red foxes ( Vulpes vulpes), and dogs ( Canis lupus familiaris) across Australia...
August 10, 2018: Journal of Wildlife Diseases
Claudia Klein, Shemanti Barua, Stefano Liccioli, Alessandro Massolo
Definitive hosts of Neospora caninum are species of canids, such as domestic dogs ( Canis lupus familiaris), coyotes ( Canis latrans) and foxes (XXXXXXX), whereas ruminants, such as cattle ( Bos taurus), sheep ( Ovis aries), and deer (Cervidae) serve as intermediate hosts. We investigated the presence of N. caninum in feces of coyotes in Calgary, Alberta, Canada. One hundred coyote fecal samples were collected from five city parks. Following DNA extraction, the presence of N. caninum DNA was determined by using real-time PCR analysis with a primer and probe pair targeting the Nc5 gene...
August 10, 2018: Journal of Wildlife Diseases
Rosanna Dammacco, Pasquale Procaccio, Vito Racanelli, Angelo Vacca, Franco Dammacco
PURPOSE: To assess the prevalence of the ocular manifestations related to the disease and/or ascribable to the administration of potentially toxic drugs in a cohort of 98 patients with systemic lupus erythematosus (SLE). METHODS: Retrospective, observational study reporting the experience of two tertiary referral centers. RESULTS: Overall, an ocular involvement was detected in 29 patients (29.6%), sometimes preceding of months the diagnosis of SLE, more often revealed at diagnosis or throughout its course...
August 10, 2018: Ocular Immunology and Inflammation
Avinash Jain, Dinesh Kumar, Anupam Guleria, Durga Prasanna Misra, Abhishek Zanwar, Smriti Chaurasia, Sandeep Kumar, Umesh Kumar, Shravan K Mishra, Ruchika Goel, Debashish Danda, Ramnath Misra
Takayasu arteritis (TA) is a large vessel vasculitis of unknown pathogenesis. Assessment of disease activity is a challenge and there is an unmet need for relevant biomarker(s). In our previous study, NMR based serum metabolomics had revealed distinctive metabolic signatures in TA patients compared with age/sex matched healthy controls and Systemic Lupus Erythematosus (SLE). In this study, we investigate whether the metabolites correlate with disease activity. Patients with TA fulfilling American College of Rheumatology (ACR) criteria were enrolled and disease activity was assessed using Indian Takayasu Clinical Activity Score using Acute Phase Reactant - Erythrocyte Sedimentation Rate [ITAS-A (ESR]...
August 10, 2018: Journal of Proteome Research
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