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Ebtihal Kamal, Lamis AbdelGadir Kaddam, Maha Dahawi, Montaser Osman, Mohammed Abdelraman Salih, Alnour Alagib, Amal Saeed
Background: Rheumatoid arthritis (RA) is autoimmune inflammatory disease that attacks the synovium of the joints. Both TNF a and interleukin-1 play crucial roles in the pathogenesis of RA. Gum Arabic (GA) is gummy exudates from Acacia senegal tree. Gum Arabic fermentation by colonic bacteria increases serum butyrate concentrations, so it is considered as prebiotic agent. Gum Arabic (GA) has anti-inflammatory activity through its derivative butyrate. To the best of our knowledge, this is the first study conducted to investigate GA intake on inflammatory markers among RA patients...
2018: International Journal of Rheumatology
Yusuke Shimakawa, Ramou Njie, Gibril Ndow, Muriel Vray, Papa Saliou Mbaye, Philippe Bonnard, Roger Sombié, Jean Nana, Vincent Leroy, Julie Bottero, Patrick Ingiliz, Gerrit Post, Bakary Sanneh, Ignatius Baldeh, Penda Suso, Amie Ceesay, Adam Jeng, Harr Freeya Njai, Shevanthi Nayagam, Umberto D'Alessandro, Isabelle Chemin, Maimuna Mendy, Mark Thursz, Maud Lemoine
BACKGROUND & AIMS: To eliminate hepatitis B virus (HBV) infection, it is essential to scale up antiviral treatment through decentralized services. However, access to the conventional tools to assess treatment eligibility (liver biopsy/Fibroscan®/HBV DNA) is limited and not affordable in resource-limited countries. We developed and validated a simple score to easily identify patients in need of HBV treatment in Africa. METHODS: As a reference, we used treatment eligibility determined by the European Association for the Study of the Liver based on alanine aminotransferase (ALT), liver histology and/or Fibroscan and HBV DNA...
June 18, 2018: Journal of Hepatology
Siri Suh
Drawing on ethnographic fieldwork conducted in Senegal between 2010 and 2011, I demonstrate how health professionals have deployed indicators such as number of women and abortion type treated in government hospitals to demonstrate commitment to global mandates on reproductive rights. These indicators obscure discrimination against women suspected of illegal abortion as health workers negotiate obstetric treatment with the abortion law. By measuring hospitals' capacity to keep women with abortion complications alive, post-abortion care (PAC) indicators have normalized survival as a state of reproductive well-being...
August 13, 2018: Medical Anthropology
Papa Ibnou Ndiaye, Landing Badji, Stacy Marie Lindshield, Jill D Pruetz
Diaguiri is a non-protected area situated in south-eastern Senegal. Chimpanzees (Pan troglodytes verus) have been living here since 1999 but information on the characteristics of their nest sites have been lacking until now. Furthermore, we implemented nest survey methods recently standardised to arid landscapes during a national chimpanzee survey. Variations in nest decay rates are poorly understood in savanna-woodland mosaic habitats. This study aims to describe in Diaguiri: (1) the distribution of chimpanzee nests and the location of their core sleeping area, (2) the tree species used for nest building, (3) the association between nests and nesting tree heights, and (4) differences in nest decay rates between habitats...
August 8, 2018: Folia Primatologica; International Journal of Primatology
Cecile Cames, Lea Pascal, Aissatou Ba, Hélène Mbodj, Baly Ouattara, Ndeye-Fatou Diallo, Philippe Msellati, Ngagne Mbaye, Haby Sy Signate, Stephane Blanche, Aminata Diack
BACKGROUND: The long-term benefits of antiretroviral treatment (ART) are associated with metabolic complications, especially lipodystrophy, which has been well described among HIV-infected adults and children on ART in developed settings. Specifically, stavudine, and to a lesser extent zidovudine and protease inhibitors (PI), have been consistently implicated in the development of lipodystrophy. In 2006, following advice from the WHO, Senegal began phasing out stavudine from first-line ART...
August 6, 2018: BMC Infectious Diseases
Natasha Howard, Helen Walls, Sadie Bell, Sandra Mounier-Jack
INTRODUCTION: Improving evidence informed decision-making in immunisation is a global health priority and many low and middle-income countries have established National Immunisation Technical Advisory Groups (NITAGs) as independent technical advisory bodies for this purpose. NITAG development and strengthening has received financial and technical support over the past decade, but relatively little evaluation. This study examined NITAGs in six low and middle-income countries (i.e. Armenia, Ghana, Indonesia, Nigeria, Senegal, Uganda), to examine functionality, quality of recommendation development, and integration with national decision-making bodies and processes...
July 31, 2018: Vaccine
Andrea Nove
INTRODUCTION: The potential for midwifery to improve sexual, reproductive, maternal, newborn and adolescent health is recognised, but midwives can only achieve this potential if they are properly educated. METHODS: A mixed-methods evaluation of the quality of midwifery education in eleven French-speaking countries in Sub-Saharan Africa was conducted between 2013 and 2015, six of which contributed data to a multi-country analysis: Benin, Congo, Ivory Coast, Mali, Mauritania and Senegal...
March 3, 2018: Santé Publique: Revue Multidisciplinaire Pour la Recherche et L'action
Gabriel Nougnignon Comlan Deguenonvo, Abdou Majib Gaye, Ibou Thiam, Chérif Mohamed Moustapha Dial, Gisèle Woto-Gaye
OBJECTIVE: To study the prevalence of atherosclerosis (aortic and coronary lesions) in Senegalese people, to determine main risks factors and morphological patterns. METHODS: A prospective autopsy study was conducted in the pathology department of Aristide Le Dantec Hospital (Dakar-Senegal) where 116 specimens aged over 5 years old were studied. RESULTS: Autopsy study of 116 Senegalese specimens for atherosclerotic lesions revealed aortic lesions in 100 cases (86%), aortic and coronary lesions both in 48 cases...
July 25, 2018: Annales de Pathologie
Nadia Amanzougaghene, Florence Fenollar, George Diatta, Cheikh Sokhna, Didier Raoult, Oleg Mediannikov
Through its unique mode of action, ivermectin represents a relatively new and very promising tool to fight against human lice, especially in cases of resistance to commonly used pediculicides. However, ivermectin resistance in the field has already begun to be reported. Therefore, understanding the mechanisms involved is a key step in delaying and tackling this phenomenon. In this study, field head lice with confirmed clinical resistance to ivermectin in rural human populations from Senegal were subjected to genetic analysis targeting GluCl gene, the primary target of ivermectin known to be involved in resistance...
July 25, 2018: International Journal of Antimicrobial Agents
Yvan Bettarel, Marine Combe, Antoinette Adingra, Awa Ndiaye, Thierry Bouvier, Jacques Panfili, Jean-Dominique Durand
Preliminary studies conducted on the human gastro-intestinal tract have revealed that enteric viral communities play a preponderant role in microbial homeostatis. However to date, such communities have never been investigated in the fish gut. Herein, we examined the main ecological traits of viruses in the digestive tract of a euryhaline fish, the tilapia Sarotherodon melanotheron. Individuals were collected at 8 different sites in Senegal covering a salinity gradient from 3 to 104‰, and showing large disparities in their organic pollutant concentrations...
July 27, 2018: Scientific Reports
Salisu M Ishaku, Nafissatou Diop, Babacar Mané, Wilson Liambila, Saumya RamaRao, Heather Clark, Harriet Birungi, Godwin Unumeri, Francis Obare
The progesterone vaginal ring (PVR) is a ring-shaped device designed for use by women in the postpartum period to regulate fertility by complementing and extending the contraceptive effectiveness of lactational amenorrhea to suppress ovulation.1 It is available in eight Latin American countries for use by breastfeeding women who want more effective modern contraceptives in addition to contraceptive benefits provided by lactational amenorrhea alone.1 The PVR is a method that can be suitable to women in sub-Saharan Africa, given the near-universal practice of breastfeeding and the current level of unmet need for contraception in the postpartum period...
June 2018: African Journal of Reproductive Health
A Mbaye, K Babaka, A A Ngaïde, M Gazal, M Faye, K Niang, A Dodo, S A Sarr, M Dioum, M Bodian, M B Ndiaye, A Kane, M Ndour-Mbaye, M Diao, B Diack, M Kane, D Diagne-Sow, I Thiaw, A Kane
OBJECTIVES: We aim to determine the prevalence of cardiovascular risk factors in the semi-rural population of the community of Gueoul in Senegal. PATIENTS AND METHOD: This is a cross-sectional, observational and descriptive study. We conducted an exhaustive survey in 2012 according to the STEPS wise approach of the world health organization against Senegalese aged of 35 years and over who resided for at least 6 months in semi-rural area in the community of Gueoul...
September 2018: Annales de Cardiologie et D'angéiologie
John R Williams, Piero Manfredi, Alessia Melegaro
BACKGROUND: Sub-Saharan Africa (SSA) continues to suffer high communicable disease burdens as its demographic transition (DT) proceeds. Although the consequent changes in population structures influence age-specific contact patterns relevant for transmission, the age distribution of immunity, and the disease burden, investigation of the potential of DT to affect infectious disease epidemiology in regions of SSA has hitherto been overlooked. With a substantial disease burden and complex epidemiology, hepatitis B virus (HBV) represents a prime example of an infection whose epidemiology may be significantly influenced by the DT...
July 25, 2018: BMC Medicine
Eric D Raile, Linda M Young, Jackline Bonabana-Wabbi, Julian Kirinya, Samba Mbaye, Lena Wooldridge, Amber N W Raile, Lori Ann Post
The international community has advocated the adoption of climate-smart agriculture (CSA) as lower-income countries deal with the negative consequences of climate change. Scaling up such policies, practices, and programs successfully will require support from a variety of local stakeholders. Such support requires alignment between CSA solutions and the problem understandings of stakeholders. However, problem understandings can differ across individuals, stakeholder groups, and geographic areas. Consequently, we examine understandings of climate problems and socioeconomic and infrastructure problems related to agriculture among different stakeholder groups in Uganda and Senegal...
March 2018: Review of Policy Research
Simona Gabrielli, Elena Maggioni, Laura Fieschi
BACKGROUND: Cervical cancer is the second most common women's cancer in less developed regions and it is the leading cause of cancer mortality among women in Senegal. Because of the high costs, cervical cancer prevention is very rare in developing countries and it is often based on visual inspection methods. The University of Parma (CUCI)  and the MANI association have developed a cervical cancer screening project addressed to rural Senegal communities. The aim of the project was to disseminate the cytocervical sampling technique among Senegalese nurses and midwives, as a completion to the local visual inspection method...
July 18, 2018: Acta Bio-medica: Atenei Parmensis
Christinah Mukandavire, Josephine Walker, Sheree Schwartz, Marie-Claude Boily, Leon Danon, Carrie Lyons, Daouda Diouf, Ben Liestman, Nafissatou Leye Diouf, Fatou Drame, Karleen Coly, Remy Serge Manzi Muhire, Safiatou Thiam, Papa Amadou Niang Diallo, Coumba Toure Kane, Cheikh Ndour, Erik Volz, Sharmistha Mishra, Stefan Baral, Peter Vickerman
INTRODUCTION: Key populations including female sex workers (FSW) and men who have sex with men (MSM) bear a disproportionate burden of HIV. However, the role of focusing prevention efforts on these groups for reducing a country's HIV epidemic is debated. We estimate the extent to which HIV transmission among FSW and MSM contributes to overall HIV transmission in Dakar, Senegal, using a dynamic assessment of the population attributable fraction (PAF). METHODS: A dynamic transmission model of HIV among FSW, their clients, MSM and the lower-risk adult population was parameterized and calibrated within a Bayesian framework using setting-specific demographic, behavioural, HIV epidemiological and antiretroviral treatment (ART) coverage data for 1985 to 2015...
July 2018: Journal of the International AIDS Society
Isaac Dennis Amoah, Poovendhree Reddy, Razak Seidu, Thor Axel Stenström
The use of sludge in agriculture has been encouraged as a means of increasing soil nutrient content and improving the water holding capacity. On the negative side, major public health concerns with sludge application prevail, mainly due to the high concentration of pathogenic microorganisms. Soil-transmitted helminths (STHs) are of major health concern in this regard, especially in endemic regions, mainly due to the high environmental resistant of the eggs combined with a low infectious dose. In this study the concentration of STH eggs in two months dried sludge from Durban, South Africa and Dakar, Senegal was determined and compared...
January 15, 2018: Journal of Environmental Management
Susan Horton, Lauren S Blum, Mamadou Diouf, Banda Ndiaye, Fatou Ndoye, Khadim Niang, Alison Greig
Background: Using twice-yearly campaigns such as Child Health Days to deliver vitamin A supplements has been a key strategy over the last 2 decades, and was an important component in helping reach the Millennium Development Goals in child health. As countries move to strengthen their routine health services under the Sustainable Development Goals, efforts are underway to shift supplementation from campaign to routine delivery. Objective: The aim of this study was to compare cost, coverage, and user satisfaction between twice-yearly campaigns and routine delivery of vitamin A supplements in Senegal...
April 2018: Current developments in nutrition
Wafa E Abaker, Frank Berninger, Gustavo Saiz, Jukka Pumpanen, Mike Starr
Background: Over the last decades sub-Saharan Africa has experienced severe land degradation and food security challenges linked to loss of soil fertility and soil organic matter (SOM), recurrent drought and increasing population. Although primary production in drylands is strictly limited by water availability, nutrient deficiencies, particularly of nitrogen (N) and phosphorus (P), are also considered limiting factors for plant growth. It is known that SOM (often measured as soil organic carbon (SOC)) is a key indicator of soil fertility, therefore, management practices that increase SOM contents, such as increasing tree cover, can be expected to improve soil fertility...
2018: PeerJ
Carine Brouat, Christophe Amidi Diagne, Khadija Ismaïl, Abdelkrim Aroussi, Ambroise Dalecky, Khalilou Bâ, Mamadou Kane, Youssoupha Niang, Mamoudou Diallo, Aliou Sow, Lokman Galal, Sylvain Piry, Marie-Laure Dardé, Aurélien Mercier
Risks related to Toxoplasma gondii infection in humans remain poorly known in Senegal. Although rodent surveys could help to assess the circulation of T. gondii, they have seldom been set up in sub-Saharan Africa. The aim of this study was to examine Toxoplasma seroprevalence in rodents from villages and towns across Senegal. Rodents were sampled in 40 localities using a standardised trapping protocol. Detection of T. gondii antibodies was performed on 1205 rodents, using a modified agglutination test (MAT) technique...
2018: Parasite: Journal de la Société Française de Parasitologie
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