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Risk pregnancies

Leena Antikainen, Jarmo Jääskeläinen, Henrikki Nordman, Raimo Voutilainen, Hanna Huopio
BACKGROUND: Maternal gestational diabetes mellitus (GDM) and overweight are associated with an increased risk of obesity and the metabolic syndrome in the adult offspring. We studied the influence of maternal GDM on prepubertal children's height, weight, body mass index (BMI), lipid and glucose metabolism, and low-grade inflammation. METHODS: A cohort of 135 prepubertal Caucasian children (age range 4.4-9.7 years) was studied in a controlled cross-sectional study...
August 15, 2018: Hormone Research in Pædiatrics
Monica C Campos, Jamille G Dombrowski, Jody Phelan, Claudio R F Marinho, Martin Hibberd, Taane G Clark, Susana Campino
Zika virus infections can cause a range of neurologic disorders including congenital microcephaly. However, while Zika infections have been notified across all regions in Brazil, there has been an unusual number of congenital microcephaly case notifications concentrated in the Northeast of the country. To address this observation, we investigated epidemiological data (2014-2016) on arbovirus co-distribution, environmental and socio-economic factors for each region in Brazil. Data on arbovirus reported cases and microcephaly were collected from several Brazilian Ministry of Health databases for each Federal unit...
2018: PloS One
Nilgun Yildirim, Aykut Bahceci
Trastuzumab and pertuzumab are monoclonal antibodies used for the treatment of breast cancer. Until now, there have been no reports on the use of pertuzumab during pregnancy and on its potential effects on the fetus. Herein, we present a breast cancer patient who received trastuzumab and pertuzumab treatment during the first 20 weeks of pregnancy. This 22-year-old patient initially diagnosed with invasive ductal carcinoma of the breast was found to be negative for estrogen receptor and progesterone receptor and positive for human epidermal growth factor receptor in the immunohistochemical examination...
September 2018: Anti-cancer Drugs
Yeela Ben Naftali, Irit Chermesh, Ido Solt, Yolanda Friedrich, Lior Lowenstein
BACKGROUND: Abnormal gestational weight gain (GWG) has been associated with adverse outcomes for mothers and their offspring. OBJECTIVES: To compare the achievement of recommended GWG and lifestyle factors in women with high-risk versus normal-risk pregnancies. METHODS: Pregnant women hospitalized in a gynecological and obstetrics department and pregnant women who arrived at a community clinic for a routine checkup were interviewed and completed questionnaires relating to weight gain and lifestyle factors (e...
July 2018: Israel Medical Association Journal: IMAJ
Frank J E Vajda, Terence J O'Brien, Janet E Graham, Alison A Hitchcock, Cecilie M Lander, Mervyn J Eadie
OBJECTIVES: To gain insight into the main advantages and disadvantages that might result from valproate being unavailable for women who intend to become pregnant. MATERIALS AND METHODS: Analysis of data from the Australian Pregnancy Register concerning pregnancies exposed to valproate (N = 501) and pregnancies where previous valproate intake had been ceased before pregnancy (N = 101). RESULTS: The risk of foetal malformation associated with valproate exposure during pregnancy was dose-related, and there was a tendency for the more major malformations, including those often managed by therapeutic abortion, for example spina bifida, to occur at higher valproate doses...
August 14, 2018: Acta Neurologica Scandinavica
Diamantis I Tsilimigras, Amir A Rahnemai-Azar, Ioannis Ntanasis-Stathopoulos, Maria Gavriatopoulou, Demetrios Moris, Eleftherios Spartalis, Jordan M Cloyd, Sharon M Weber, Timothy M Pawlik
INTRODUCTION: Hepatic adenomas (HAs) are a benign and relatively rare type of liver neoplasms. We review the diagnosis, evaluation, and potential therapeutic management options for patients with HA. METHODS: A comprehensive review of the English literature was performed utilizing MEDLINE/PubMed and Web of Science databases with end of search date the 30th April of 2018. In PubMed, the terms "hepatocellular," "hepatic," "liver," and "adenoma," "adenomatosis" were searched in the title and/or abstract...
August 14, 2018: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
María Limones, Julio Sevillano, María G Sánchez-Alonso, Emilio Herrera, María Del Pilar Ramos-Álvarez
BACKGROUND: Although recent studies have investigated the effect of maternal nutrition on metabolic programming of the offspring, the question whether a nutritional insult during early gestation favours an altered metabolic state of the mother that persists during the remainder period of pregnancy, when foetal growth is maximal, remains to be answered. METHODS: To address this issue, we analysed the effect of 40% food restriction during the first 12 days of gestation on glucose tolerance, as well as on liver and adipose tissue metabolism, in Sprague-Dawley pregnant rats...
August 14, 2018: European Journal of Nutrition
Phil C Boyle, Theun de Groot, Karolina M Andralojc, Tracey A Parnell
Objectives: To determine the live birth rate for patients who chose to undergo treatment with Restorative Reproductive Medicine (RRM) after previous IVF (includes ICSI). To look at birth outcomes with RRM after IVF, particularly rates of twin and higher order pregnancies, premature birth, low birth weight, and potential cost savings achieved with RRM. Setting: Two outpatient clinics in Ireland providing advanced RRM treatment of infertility. Materials and methods: All patients presenting between January 2004 and January 2010, with a history of infertility and previous IVF treatment were included if they proceeded beyond the initial consultation and began treatment...
2018: Frontiers in Medicine
Cayla M O'Hair, Kathryn Armstrong, Helena J V Rutherford
Background: A significant number of women continue to smoke tobacco during pregnancy despite the increased risk of complications to fetal and infant development. Therefore, effective interventions are needed to assist pregnant women with the process of tobacco cessation. Traditional counseling programs have demonstrated some success; however, novel approaches that target stress as a mechanism in the maintenance of addiction would be valuable. Objective: To examine the role of stress in addiction and the utility of massage therapy to decrease stress during pregnancy...
August 2018: International Journal of Therapeutic Massage & Bodywork
Sofia Nahavandi, Jas-Mine Seah, Alexis Shub, Christine Houlihan, Elif I Ekinci
Large birthweight, or macrosomia, is one of the commonest complications for pregnancies affected by diabetes. As macrosomia is associated with an increased risk of a number of adverse outcomes for both the mother and offspring, accurate antenatal prediction of fetal macrosomia could be beneficial in guiding appropriate models of care and interventions that may avoid or reduce these associated risks. However, current prediction strategies which include physical examination and ultrasound assessment, are imprecise...
2018: Frontiers in Endocrinology
Luuk J J Scheres, Ingrid M Bistervels, Saskia Middeldorp
Pregnancy is a hemostatic challenge: women are prone to thromboembolism during their pregnancy and at the same time, especially during delivery, there is substantial risk of bleeding. Pregnant women are often excluded from randomized controlled trials, and high quality evidence regarding optimal anticoagulant management is thus lacking. Anticoagulants are being used in pregnancy for prevention and treatment of various pregnancy complications such as thrombotic events, preeclampsia and pregnancy loss. When anticoagulant therapy is necessary, special attention should be given to both woman and unborn child...
August 6, 2018: Blood Reviews
Rasheda Khanam, Anne Shee Cc Lee, Malathi Ram, M A Quaiyum, Nazma Begum, Allysha Choudhury, Parul Christian, Luke C Mullany, Abdullah H Baqui
OBJECTIVE: The present study examined the prevalence of and risk factors for malnutrition in a population-based cohort of women of childbearing age in rural Bangladesh. DESIGN: A cross-sectional study that collected pre-pregnancy weight, height, and data on selected risk factors for nutritional status of women. SETTING: The study was conducted in Sylhet District of Bangladesh. SUBJECTS: Study subjects included 13 230 non-pregnant women of childbearing age...
August 15, 2018: Public Health Nutrition
Mohamed M Ali, John Cleland
BACKGROUND: HIV and unintended pregnancy are major interrelated concerns in sub-Saharan Africa. Focussing on single women aged 15-24 years we assess trends in key behaviours that affect both outcomes. METHODS: We performed a secondary analysis of public-access data sets from 112 surveys from 36 countries in the region, conducted between 1991 and 2015. We examined trends over 20 years in primary abstinence (virginity), secondary abstinence (no sex in past 3 months) among sexually experienced women, current use of modern contraception and condom use at most recent coitus among sexually active women...
August 14, 2018: Reproductive Health
D Yaw Atiglo, Adriana A E Biney
BACKGROUND: Young women in sub-Saharan Africa continue to experience unintended pregnancies despite effective contraceptive methods being more readily available than ever. This study sought to determine the correlates of met need for contraceptives and sexual inactivity among young women in Ghana who want to postpone childbearing. We examine this among all women and then separately by marital status. METHODS: Using data from 1532 females aged 15-24 years from the 2014 Ghana Demographic and Health Survey, we conducted descriptive and multinomial logistic regression analyses to assess sociodemographic, economic and obstetric determinants of the type of family planning method (current abstinence, modern contraceptive method) used by married and unmarried young women...
August 14, 2018: BMC Women's Health
Carmen Imma Aquino, Maurizio Guida, Gabriele Saccone, Yuri Cruz, Amerigo Vitagliano, Fulvio Zullo, Vincenzo Berghella
BACKGROUND: Different techniques have been analyzed to reduce the risk of perineal trauma during labor. OBJECTIVE: To evaluate whether perineal massage techniques during vaginal delivery decreases the risk of perineal trauma. SEARCH STRATEGY: Electronic databases (Medline, Prospero, Scopus,, Embase, ScienceDirect, the Cochrane Library, SciELO) were searched from their inception until February 2018. No restrictions for language or geographic location were applied...
August 14, 2018: Journal of Maternal-fetal & Neonatal Medicine
Bente Mertz Nørgård, Bjarne Magnussen, Jens Fedder, Punyanganie S de Silva, Sonja Wehberg, Sonia Friedman
Backgroud: Women with inflammatory bowel disease (IBD) might have an increased tendency to choose an elective abortion due to a fear that their fetus could be harmed by use of medications, disease flares during pregnancy, or for genetic reasons. We examined the risk of elective abortions in women with ulcerative colitis (UC) and Crohn's disease (CD) compared with women without IBD. Methods: This nationwide cohort study, based on Danish health registries, comprises all registered pregnancies from 1996 through 2015...
August 10, 2018: Inflammatory Bowel Diseases
Pintu Paul
STUDY OBJECTIVE: This study aims to examine the association between maternal age at marriage and selected pregnancy outcomes- stillbirth, miscarriage, and complications during pregnancy, labor, and postpartum period. STUDY DESIGN: Cross-sectional study. SETTING: India. PARTICIPANTS: A total number of 35,253 ever-married women aged 15-49 years from the second round of India Human Development Survey (IHDS-2) were utilized to examine the association between maternal age at marriage and stillbirth and miscarriage...
August 11, 2018: Journal of Pediatric and Adolescent Gynecology
Chandra Kailasam, Heather Griffith, Paul Wilson, Uma Gordon
OBJECTIVE: Coasting is a well-known strategy to decrease severity of Ovarian Hyperstimulation Syndrome (OHSS). The purpose of this study is to assess the effect of Coasting on blastocyst development and subsequent clinical outcome following exclusive blastocyst transfer. METHODS: We conducted an observational cohort study of patients having blastocyst transfer following IVF/ICSI treatment. Patients undergoing IVF/ICSI cycles were included in the study. Patients at risk of OHSS were coasted...
August 14, 2018: JBRA Assisted Reproduction
Brandie D Taylor, Catherine L Haggerty, Roberta B Ness, David M Hougaard, Kristin Skogstrand, James M Roberts, Jørn Olsen
PROBLEM: A handful of studies report sexual dimorphism in the maternal angiogenic profile possibly influencing placental development and preeclampsia risk. This secondary analysis explored associations between fetal sex and soluble fms-like tyrosine kinase-1 (sFLT) and endoglin (9-35 weeks gestation) using data from a nested case-control study within the Danish National Birth Cohort. METHOD OF STUDY: A total of 448 preeclamptic women and 328 normotensive women had data on sFLT and endoglin...
August 14, 2018: American Journal of Reproductive Immunology: AJRI
Vanessa Arizo-Luque, Ana M García, Marisa Estarlich, Ferran Ballester, Guillermo Fernández-Tardón, Adonina Tardón, Mónica Guxens, Martine Vrijheid, Aitana Lertxundi, Loreto Santa-Marina, Elena Ronda-Pérez
OBJECTIVE: Published studies are not conclusive on the impact of certain occupational exposures in pregnancy, stressing the need to consider the double role, professional and family, of women. The objective of this study is to evaluate the effect of employment and domestic load on the duration of pregnancy and fetal development. METHODS: Using Univariate and Multivariate regression models, we studied the association of preterm deliveries (PPT) (<37 weeks), full term newborns with low weight (BPT) (<2500g) and small for their gestational age (PEG) (<10th percentile) in weight, length and head circumference according to work situation (employment/non-employment) and domestic load (low/ medium/ high) in 2506 women...
August 17, 2018: Revista Española de Salud Pública
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