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JOURNAL ARTICLE
Henrique Andrade R Fonseca, Maria Cristina O Izar, Luciano F Drager, Ibraim M Pinto, José Francisco K Saraiva, João Fernando Monteiro Ferreira, Álvaro Avezum, Francisco Antonio Fonseca, Otávio Berwanger
BACKGROUND: Primary prevention of cardiovascular disease (CVD) remains a major challenge, especially in communities of low- and middle-income countries with poor medical assistance influenced by distinct local, financial, infrastructural, and resource-related factors. OBJECTIVE: This a community-based study aimed to determine the proportion and prevalence of uncontrolled cardiovascular risk factors (CRF) in Brazilian communities. METHODS: The EPICO study was an observational, cross-sectional, and community clinic-based study...
2023: Global Heart
#2
JOURNAL ARTICLE
Alfredo Tagarro, Sara Domínguez-Rodríguez, Juan Miguel Mesa, Cristina Epalza, Carlos Grasa, María Isabel Iglesias-Bouzas, Elisa Fernández-Cooke, Cristina Calvo, Serena Villaverde, David Torres-Fernández, Ana Méndez-Echevarria, Inés Leoz, María Fernández-Pascual, Jesús Saavedra-Lozano, Beatriz Soto, David Aguilera-Alonso, Jacques G Rivière, Victoria Fumadó, Leticia Martínez-Campos, Ana Vivanco, Francisco Javier Pilar-Orive, Pedro Alcalá, Beatriz Ruiz, Ana López-Machín, Manuel Oltra, Cinta Moraleda
Scarce evidence exists about the best treatment for multi-system inflammatory syndrome (MIS-C). We analyzed the effects of steroids, intravenous immunoglobulin (IVIG), and their combination on the probability of discharge over time, the probability of switching to second-line treatment over time, and the persistence of fever 2 days after treatment. We did a retrospective study to investigate the effect of different treatments on children with MIS-C from 1 March 2020 to 1 June 2021. We estimated the time-to-event probability using a Cox model weighted by propensity score to balance the baseline characteristics...
January 2023: European Journal of Pediatrics
#3
JOURNAL ARTICLE
R Polo, X García-Albéniz, C Terán, M Morales, D Rial-Crestelo, M A Garcinuño, M García Del Toro, C Hita, J L Gómez-Sirvent, L Buzón, A Díaz de Santiago, J L Pérez Arellano, J Sanz, P Bachiller, E Martínez Alfaro, V Díaz-Brito, M Masiá, A Hernández-Torres, J Guerra, J Santos, P Arazo, L Muñoz, J R Arribas, P Martínez de Salazar, S Moreno, M A Hernán, J Del Amo, Julia Del Amo, Rosa Polo, Santiago Moreno, Juan Berenguer, Esteban Martínez, Miguel Hernán, Pablo Martínez de Salazar, Xabier García de Albéniz
OBJECTIVE: To assess the effect of hydroxychloroquine (HCQ) and Tenofovir disoproxil fumarate/Emtricitabine (TDF/FTC) as pre-exposure prophylaxis on COVID-19 risk. METHODS: EPICOS is a double-blind, placebo-controlled randomized trial conducted in Spain, Bolivia, and Venezuela. Healthcare workers with negative SARS-CoV-2 IgM/IgG test were randomly assigned to: daily TDF/FTC plus HCQ for 12 weeks, TDF/FTC plus HCQ placebo, HCQ plus TDF/FTC placebo and TDF/FTC placebo plus HCQ placebo...
August 5, 2022: Clinical Microbiology and Infection
#4
JOURNAL ARTICLE
Cristina Epalza, Luis Prieto-Tato, Rosa Pino, Paula Escartín-Paredes, Inés Leoz, Carlos Grasa, Ana Vivanco-Allende, Jacques G Rivière, Jaume Carrasco-Colom, Olatz Villate, Victoria Fumadó, Concepción Hermoso-Ibañez, Blanca Herrero, David Aguilera-Alonso, Alfredo Tagarro, Cinta Moraleda
In this cohort of 42 adolescents with a previous multisystem inflammatory syndrome (MIS-C) diagnosis, 32 (76.2%) were vaccinated with COVID-19 vaccines, with a low incidence of relevant adverse events. More importantly, no new MIS-C or myocarditis occurred after a median of 10 weeks (range 5.3-19.7) post-vaccination.
October 25, 2022: Journal of the Pediatric Infectious Diseases Society
#5
JOURNAL ARTICLE
Cinta Moraleda, Sara Domínguez-Rodríguez, Juan Miguel Mesa, Paula García-Sánchez, María de la Serna, José Antonio Alonso-Cadenas, Amanda Bermejo, Gema Sabrido, Leticia Martínez-Campos, Aránzazu Flavia González-Posada, Marta Illán-Ramos, Elena Cobos-Carrascosa, Álvaro Ballesteros, Juan Carlos Galán, Francisco Llorente, David Aguilera-Alonso, Ana Belén Jiménez, Pilar Catalán, Elias Dahdouh, Ignacio Navarro, Bárbara Fernández-Garoz, Pablo Mendoza, Concepción Pérez-Jorge, Teresa Cabezas-Fernández, Daniel Blázquez-Gamero, Gonzalo Rivas, Patricia Gonzalez-Donapetry, Elena Sáez, Jovita Fernández-Pinero, Jesús Lucas-Fernández, Elisa Pérez-Ramírez, Paloma Merino, Sandra Miragaya, Jorge Lorente, Irene Iglesias, Alfredo Tagarro
OBJECTIVES: To evaluate the performance of oral saliva swab (OSS) reverse transcription PCR (RT-PCR) compared with RT-PCR and antigen rapid diagnostic test (Ag-RDT) on nasopharyngeal swabs (NPS) for SARS-CoV-2 in children. DESIGN: Cross-sectional multicentre diagnostic study. SETTING: Study nested in a prospective, observational cohort (EPICO-AEP) performed between February and March 2021 including 10 hospitals in Spain. PATIENTS: Children from 0 to 18 years with symptoms compatible with Covid-19 of ≤5 days of duration were included...
June 10, 2022: Archives of Disease in Childhood
#6
JOURNAL ARTICLE
Gen Miura, Yoshihito Ozawa, Yuki Shiko, Yohei Kawasaki, Takayuki Iwase, Tadami Fujiwara, Takayuki Baba, Hideki Hanaoka, Shuichi Yamamoto
INTRODUCTION: Previously, we conducted a clinical trial to evaluate the safety and efficacy of transdermal electrical stimulation (TdES) with skin electrodes to improve the visual functions in patients with retinitis pigmentosa (RP). No adverse events were related to the treatment during follow-up examinations, and TdES significantly improved the mean visual acuity and visual field sensitivity. METHODS AND ANALYSIS: We developed a study protocol for a prospective, multicentre, randomised, double-masked and sham-controlled clinical trial, planned to commence on June 2021...
May 6, 2022: BMJ Open
#7
JOURNAL ARTICLE
Alfredo Tagarro, Elena Cobos-Carrascosa, Serena Villaverde, Francisco-Javier Sanz-Santaeufemia, Carlos Grasa, Antoni Soriano-Arandes, Alicia Hernanz, María Luisa Navarro, Rosa Pino, Cristina Epalza, Rosa Batista, Jana Rizo, María-Isabel Iglesias-Bouzas, Paula Rodríguez-Molino, Sara Villanueva-Medina, Jaime Carrasco-Colom, José-Antonio Alonso-Cadenas, María-José Mellado, Blanca Herrero, Susana Melendo, Mercedes De La Torre, Lourdes Calleja, Cristina Calvo, María Urretavizcaya-Martínez, Itziar Astigarraga, Ana Menasalvas, María Penin, Olaf Neth, Arantxa Berzosa, María De Ceano-Vivas, Paula Vidal, Isabel Romero, Raúl González, María Luz García, Juan-Miguel Mesa, Álvaro Ballesteros, María Bernardino, Cinta Moraleda
We aimed to identify the spectrum of disease in children with COVID-19, and the risk factors for admission in paediatric intensive care units (PICUs). We conducted a multicentre, prospective study of children with SARS-CoV-2 infection in 76 Spanish hospitals. We included children with COVID-19 or multi-inflammatory syndrome (MIS-C) younger than 18 years old, attended during the first year of the pandemic. We enrolled 1200 children. A total of 666 (55.5%) were hospitalised, and 123 (18.4%) required admission to PICU...
November 5, 2021: European Journal of Pediatrics
#8
JOURNAL ARTICLE
Cristina Calvo, Clara Udaondo
No abstract text is available yet for this article.
November 2021: Journal of Rheumatology
#9
JOURNAL ARTICLE
A Tagarro, F J Sanz-Santaeufemia, C Grasa, E Cobos, J Yebra, J A Alonso-Cadenas, F Baquero-Artigao, Guzmán Jm Mesa, Seoane B Perez, C Calvo, M L Herreros, C Epalza, S Melendo, S Dominguez-Rodriguez, P Vidal, M Pacheco, A Ballesteros, M Bernardino, S Villanueva-Medina, Molino P Rodríguez, Castro S Miragaya, J Rivière, R Garcés, B Santiago, V Fumadó, M Urretavizcaya-Martínez, M L García-García, M Penín, F Cava, E Sáez, M I Iglesias-Bouzas, B Herrero, T Reinoso, C Moraleda
OBJECTIVES: To determine the time to RT-PCR negativity after the first positive RT-PCR test, factors associated with longer time to RT-PCR negativity, proportion of children seroconverting after proven SARS-CoV-2 infection, and factors associated with the lack of seroconversion. STUDY DESIGN: EPICO-AEP is a multicenter study conducted in Spanish children to assess the characteristics of COVID-19. In a subset of patients, three serial RT-PCR tests on nasopharyngeal swab specimens were performed after the first RT-PCR test, and IgG serology for SARS-CoV-2 antibodies was performed in the acute and follow up (<14 and ≥14 days after diagnosis) phase...
September 24, 2021: Journal of Pediatrics
#10
JOURNAL ARTICLE
Sara Domínguez-Rodríguez, Serena Villaverde, Francisco J Sanz-Santaeufemia, Carlos Grasa, Antoni Soriano-Arandes, Jesús Saavedra-Lozano, Victoria Fumadó, Cristina Epalza, Miquel Serna-Pascual, José A Alonso-Cadenas, Paula Rodríguez-Molino, Joan Pujol-Morro, David Aguilera-Alonso, Silvia Simó, Sara Villanueva-Medina, M Isabel Iglesias-Bouzas, M José Mellado, Blanca Herrero, Susana Melendo, Mercedes De la Torre, Teresa Del Rosal, Pere Soler-Palacin, Cristina Calvo, María Urretavizcaya-Martínez, Marta Pareja, Fátima Ara-Montojo, Yolanda Ruiz Del Prado, Nerea Gallego, Marta Illán Ramos, Elena Cobos, Alfredo Tagarro, Cinta Moraleda
BACKGROUND: We aimed to identify risk factors causing critical disease in hospitalized children with COVID-19 and to build a predictive model to anticipate the probability of need for critical care. METHODS: We conducted a multicenter, prospective study of children with SARS-CoV-2 infection in 52 Spanish hospitals. The primary outcome was the need for critical care. We used a multivariable Bayesian model to estimate the probability of needing critical care. RESULTS: The study enrolled 350 children from March 12, 2020, to July 1, 2020: 292 (83...
August 1, 2021: Pediatric Infectious Disease Journal
#11
JOURNAL ARTICLE
Sveinung Gundersen, Sanjay Boddu, Salvador Capella-Gutierrez, Finn Drabløs, José M Fernández, Radmila Kompova, Kieron Taylor, Dmytro Titov, Daniel Zerbino, Eivind Hovig
Background: Many types of data from genomic analyses can be represented as genomic tracks, i.e. features linked to the genomic coordinates of a reference genome. Examples of such data are epigenetic DNA methylation data, ChIP-seq peaks, germline or somatic DNA variants, as well as RNA-seq expression levels. Researchers often face difficulties in locating, accessing and combining relevant tracks from external sources, as well as locating the raw data, reducing the value of the generated information. Description of work: We propose to advance the application of FAIR data principles (Findable, Accessible, Interoperable, and Reusable) to produce searchable metadata for genomic tracks...
2021: F1000Research
#12
JOURNAL ARTICLE
Eduard Vieta, Jordi Alonso, Víctor Pérez-Sola, Miquel Roca, Teresa Hernando, Antoni Sicras-Mainar, Aram Sicras-Navarro, Berta Herrera, Andrea Gabilondo
Depressive Disorders are the most common psychiatric diagnoses in the general population. To estimate the frequency, costs associated with Depressive Disorders in usual clinical practice, and in the whole Spanish population, a longitudinal, retrospective, observational study was carried out using data from the BIG-PAC database®. Study population: all patients aged ≥ 18 years with a diagnosis of a Depressive Disorder in 2015-2017. Prevalence was computed as the proportion of Depressive Disorder cases in the adult general population, and the incidence rate, as the number of new Depressive Disorder cases diagnosed per 1,000 person-years in the population using health services, during 2015-2017...
May 28, 2021: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
#13
MULTICENTER STUDY
David Aguilera-Alonso, Sara Murias, Amelia Martínez-de-Azagra Garde, Antoni Soriano-Arandes, Marta Pareja, Enrique Otheo, Cinta Moraleda, Alfredo Tagarro, Cristina Calvo
Knowledge of thrombosis in children with SARS-CoV-2 is scarce. In this multicentre national cohort of children with SARS-CoV-2 involving 49 hospitals, 4 patients out of 537 infected children developed a thrombotic complication (prevalence of 0.7% (95% CI: 0.2% to 1.9%) out of the global cohort and 1.1% (95% CI: 0.3% to 2.8%) out of the hospitalised patients). We describe their characteristics and review other published paediatric cases. Three out of the four patients were adolescent girls, and only two cases had significant thrombotic risk factors...
November 2021: Archives of Disease in Childhood
#14
JOURNAL ARTICLE
Daniel Blázquez-Gamero, Cristina Epalza, José Antonio Alonso Cadenas, Lourdes Calleja Gero, Cristina Calvo, Paula Rodríguez-Molino, María Méndez, Maria Del Mar Santos, Victoria Fumadó, María Fernanda Guzmán, Antoni Soriano-Arandes, Ana B Jiménez, Maria Penin, Elvira Cobo-Vazquez, Marta Pareja, Zulema Lobato, Miquel Serna, Rafael Delgado, Cinta Moraleda, Alfredo Tagarro
Fever without source (FWS) in infants is a frequent cause of consultation at the emergency department, and the emergence of SARS-CoV-2 could affect the approach to those infants. The aim of this study is to define the clinical characteristics and rates of bacterial coinfections of infants < 90 days with FWS as the first manifestation of SARS-CoV-2 infection. This is a cross-sectional study of infants under 90 days of age with FWS and positive SARS-CoV2 PCR in nasopharyngeal swab/aspirate, attended at the emergency departments of 49 Spanish hospitals (EPICO-AEP cohort) from March 1 to June 26, 2020...
July 2021: European Journal of Pediatrics
#15
JOURNAL ARTICLE
Alberto Borobia, Irene García-García, Lucía Díaz-García, Amelia Rodríguez-Mariblanca, Lucía Martínez de Soto, Jaime Monserrat Villatoro, Enrique Seco Meseguer, Juan J González, Jesús Frías Iniesta, Elena Ramírez García, Jose Ramón Arribas, Antonio J Carcas-Sansuán
BACKGROUND: In April 2020, two independent clinical trials (CT) to assess SARS-CoV-2 prophylaxis in healthcare workers were started in our Hospital: MeCOVID (melatonin vs placebo) and EPICOS (tenofovir disoproxil/emtricitabine vs hydroxychloroquine vs the combination of both vs placebo). OBJECTIVE: We aim to evaluate the motivations to participate and the reasons to choose one or another. METHODS: Both CTs were offered to personnel through the internal news bulletin...
February 1, 2021: Journal of Medical Internet Research
#16
JOURNAL ARTICLE
Cristina Calvo, Clara Udaondo
SARS-CoV-2 infection in children is relatively mild. Approximately 10% of identified cases are pediatric[1], with a small proportion needing hospitalization. About 25-60% of children admitted with COVID-19 have comorbidities[2,3].
February 1, 2021: Journal of Rheumatology
#17
MULTICENTER STUDY
Serena Villaverde, Sara Domínguez-Rodríguez, Gema Sabrido, Conchita Pérez-Jorge, Marta Plata, María Pilar Romero, Carlos Daniel Grasa, Ana Belén Jiménez, Elena Heras, Antonio Broncano, María Del Mar Núñez, Marta Illán, Paloma Merino, Beatriz Soto, David Molina-Arana, Amanda Bermejo, Pablo Mendoza, Manuel Gijón, Begoña Pérez-Moneo, Cinta Moraleda, Alfredo Tagarro
We conducted a multicenter clinical validity study of the Panbio coronavirus disease 2019 Antigen Rapid Test of nasopharyngeal samples in pediatric patients with coronavirus disease 2019-compatible symptoms of ≤5 days of evolution. Our study showed limited accuracy in nasopharyngeal antigen testing: overall sensitivity was 45.4%, and 99.8% of specificity, positive-predictive value was 92.5%.
May 2021: Journal of Pediatrics
#18
JOURNAL ARTICLE
Francesca Gallè, Elita Anna Sabella, Giovanna Da Molin, Osvalda De Giglio, Giuseppina Caggiano, Valeria Di Onofrio, Stefano Ferracuti, Maria Teresa Montagna, Giorgio Liguori, Giovanni Battista Orsi, Christian Napoli
Background: On February 2020, the novel coronavirus (2019-nCoV) epidemic began in Italy. In order to contain the spread of the virus, the Italian government adopted emergency measures nationwide, including closure of schools and universities, workplaces and subsequently lockdown. This survey was carried out among Italian undergraduates to explore their level of knowledge about the epidemic and the behaviors they adopted during the lockdown. Methods: An electronic questionnaire was administered to the students attending three Italian universities...
May 16, 2020: International Journal of Environmental Research and Public Health
#19
JOURNAL ARTICLE
Stefan Munker, Martin Vogelhuber, Jan Bornschein, Christian Stroszczynski, Matthias Evert, Hans Schlitt, Wolfgang Herr, Andreas Teufel
High-grade neuroendocrine neoplasms (NEN) comprise a rare entity. Due to the lack of randomized controlled trials, therapy recommendations were mainly extrapolated from its pulmonary analogue, small cell lung cancer and mostly validated in small retrospective case series. The multicentric Nordic NEC Study of gastro-entero-pancreatic (GEP) and cancer of unknown primary (CUP) high-grade neuroendocrine neoplasms showed a significant disease control upon treatment with etoposide and platinum-based chemotherapies 1...
January 2, 2020: Zeitschrift Für Gastroenterologie
#20
JOURNAL ARTICLE
Rafael Zaragoza, Ricard Ferrer, Pedro Llinares, Emilio Maseda, Alejandro Rodríguez, Santiago Grau, Guillermo Quindós
BACKGROUND: A high quality integrated process in the clinical setting of non-neutropenic critically ill patients at risk for invasive candidiasis is a necessary tool to improve the management of these patients. AIMS: To identify the key points on invasive candidiasis in order to develop a set of recommendations with a high level of consensus required for the creation of a total quality integrated process for the management of non-neutropenic critically ill patients at risk of invasive candidiasis...
July 2017: Revista Iberoamericana de Micología
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