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https://www.readbyqxmd.com/read/30093238/acceptance-rate-and-sociological-factors-involved-in-the-switch-from-originator-to-biosimilar-etanercept-sb4
#1
Marc Scherlinger, Emmanuel Langlois, Vincent Germain, Thierry Schaeverbeke
OBJECTIVE: To study acceptance rate and factors influencing acceptance of the switch from originator etanercept (Enbrel©) to biosimilar etanercept (SB4, Bénépali©) in patients with rheumatic disease. METHODS: Patients with a well-controlled rheumatic disease consulting in our rheumatology department were offered the switch for SB4. After oral and written information concerning biosimilar, free choice to accept the switch was left to the patients. The main outcome was primary switch acceptance rate defined by switch acceptance during the initial consult...
July 20, 2018: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/30075040/rheumatoid-arthritis-vs-osteoarthritis-comparison-of-demographics-and-trends-of-joint-replacement-data-from-the-nationwide-inpatient-sample
#2
Alexander J Kurdi, Benjamin A Voss, Tony H Tzeng, Steve L Scaife, Mouhanad M El-Othmani, Khaled J Saleh
Current literature regarding complications following total joint arthroplasty have primarily focused on patients with osteoarthritis (OA), with less emphasis on the trends and in-hospital outcomes of rheumatoid arthritis (RA) patients undergoing these procedures. The purpose of this study is to analyze the outcomes and trends of RA patients undergoing total knee arthroplasty (TKA) or total hip arthroplasty (THA) compared to OA patients. Data from the Nationwide Inpatient Sample from 2006 to 2011 was extracted using the International Classification of Diseases, Ninth Revision codes for patients that received a TKA or THA...
July 2018: American Journal of Orthopedics
https://www.readbyqxmd.com/read/30071930/muscle-loss-following-a-single-high-dose-intramuscular-injection-of-corticosteroids-to-treat-disease-flare-in-patients-with-rheumatoid-arthritis
#3
Andrew B Lemmey, Thomas J Wilkinson, Celine M Perkins, Luke A Nixon, Fazal Sheikh, Jeremy G Jones, Yasmeen A Ahmad, Thomas D O'brien
OBJECTIVE: Adverse changes in body composition, specifically decreased muscle mass (MM) and increased fat mass, characterize rheumatoid arthritis (RA). These changes, termed rheumatoid cachexia (RC), are important contributors to the disability and elevated co-morbidity risk of RA. Recently, we observed substantial muscle loss (~2 kg) in a patient with RA following a single intramuscular (IM) corticosteroid (CS) injection to treat a disease flare. The aim of the current study is to determine whether this apparent iatrogenic effect of IM CS is typical, i...
April 2, 2018: European Journal of Rheumatology
https://www.readbyqxmd.com/read/30051260/autoimmunity-in-2017
#4
REVIEW
Carlo Selmi
The number of peer-reviewed articles published during the 2017 solar year and retrieved using the "autoimmunity" key word increased significantly compared to 2016 while maintaining a stable share within the immunology field, following years with alternated fortunes. A detailed arbitrary analysis of the published articles in leading immunology and autoimmunity journals provides a privileged viewpoint on the current trends of research from both basic and clinical studies. Indeed, we are observing that major steps forward are found for rheumatoid arthritis, systemic lupus erythematosus, and systemic sclerosis, among others...
July 26, 2018: Clinical Reviews in Allergy & Immunology
https://www.readbyqxmd.com/read/30047807/new-strategies-for-patenting-biological-medicines-used-in-rheumatoid-arthritis-treatment
#5
Rodrigo Ayres de Oliveira, Iolanda M Fierro, Eliezer Jesus de Lacerda Barreiro, Nubia Gabriela Benício Chedid
Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by an inflammatory process, with a global prevalence ranging from 0.3% to 1%. The overall cost of RA drugs is estimated in $20 billion worldwide and projected to grow to $36 billion by 2021. The current RA treatment strategy consists of the aggressive therapy directed to specific targets, after diagnostic confirmation and the stepped therapy directed by the stage of the disease, aiming at the clinical remission. Conventional (methotrexate, sulfasalazine, leflunomide) and biological (infliximab, adalimumab, tocilizumab) disease modifying antirheumatic drugs may fail, produce only partial responses, or unwanted side effects, and consequently new antirheumatic drugs are being developed to overcome these limitations...
July 26, 2018: Expert Opinion on Therapeutic Patents
https://www.readbyqxmd.com/read/30045854/maresin-1-improves-the-treg-th17-imbalance-in-rheumatoid-arthritis-through-mir-21
#6
Shengwei Jin, Huaijun Chen, Yongsheng Li, Hao Zhong, Weiwei Sun, Jianmin Wang, Tingting Zhang, Jinglan Ma, Songfan Yan, Jiangang Zhang, Qingqing Tian, Xinyu Yang, Jianguang Wang
OBJECTIVE: Treg/Th17 imbalance plays an important role in rheumatoid arthritis (RA). Maresin 1 (MaR1) prompts inflammation resolution and regulates immune responses. We explored the effect of MaR1 on RA progression and investigated the correlation between MaR1 and Treg/Th17 balance. METHODS: Both patients with RA and healthy controls were recruited into the study. Collagen-induced arthritis (CIA) model was constructed to detect the clinical score, histopathological changes and Treg/Th17 ratio...
July 25, 2018: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/30032973/on-the-origin-of-rheumatoid-factors-insights-from-analyses-of-variable-region-sequences
#7
Willem J J Falkenburg, Helen J von Richthofen, Theo Rispens
OBJECTIVES: Rheumatoid factors (RFs) are thought to play an important role in rheumatoid arthritis (RA), but are also found in healthy donors (HDs). Previous studies examined variable region sequences of these autoantibodies at a time when knowledge of the human germline repertoire was incomplete. Here we collected and analyzed RF sequence data from the literature to elucidate how RFs develop and whether their characteristics differ between RA patients and HDs. METHODS: A database was built containing nucleotide sequences of RF heavy and light chain variable domains and characteristics including affinity, isotype and specificity, all collected from published papers...
June 24, 2018: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/30025962/serum-retinol-binding-protein-4-is-associated-with-insulin-resistance-in-patients-with-early-and-untreated-rheumatoid-arthritis
#8
Yanlin Wei, Nannan Xia, Weifeng Zhang, Jiashu Huang, Zhijuan Ren, Lijuan Zhu, Zhenshan Zhang, Lei Yang
OBJECTIVE: Retinol-binding protein 4 (RBP4), systemic inflammation and insulin resistance(IR) are linked, yet the determinants of RBP4 and its impact on IR in rheumatoid arthritis (RA) are incompletely understood. The aim of this study was to explore the prevalence of IR in RA and investigate whether the serum levels of RBP4 were associated with IR in patients with RA. METHODS: In this study, 403 individuals with newly diagnosed and untreated RA were consecutively recruited...
July 16, 2018: Joint, Bone, Spine: Revue du Rhumatisme
https://www.readbyqxmd.com/read/30017519/anti-tnf-modulation-reduces-myocardial-inflammation-and-improves-cardiovascular-function-in-systemic-rheumatic-diseases
#9
Ntobeko A B Ntusi, Jane M Francis, Emily Sever, Alexander Liu, Stefan K Piechnik, Vanessa M Ferreira, Paul M Matthews, Matthew D Robson, Paul B Wordsworth, Stefan Neubauer, Theodoros D Karamitsos
BACKGROUND: Rheumatoid arthritis (RA), ankylosing spondylitis (AS) and psoriatic arthritis (PsA) are common disorders associated with increased rates of cardiovascular disease (CVD), but the contribution of cytokine-induced inflammation to impaired cardiovascular function in these conditions remains poorly understood. OBJECTIVES: We assessed the effect of anti-TNF therapy on myocardial and vascular function, myocardial tissue characteristics and perfusion in inflammatory arthropathy and systemic rheumatic disease (IASRD) patients, using cardiovascular magnetic resonance (CMR)...
June 25, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29992393/adverse-childhood-experience-and-rheumatic-diseases
#10
Ana Paula Lopes Luiz, Heloisa de Alencar Antico, Thelma Larocca Skare, Angelica Beate Winter Boldt, Renato Nisihara
It has been suggested that the adaptive stress response may be disrupted by life adverse events such as childhood maltreatment. To investigate if the number of adverse childhood experiences (ACEs) increases susceptibility to systemic lupus erythematosus (SLE), spondyloarthritis (SpA), scleroderma (SSc), and rheumatoid arthritis (RA), we interviewed 315 patients with rheumatic disease (100 SLE; 40 SSc; 60 SpA; 115 RA) and 272 controls, using questions of the ACEs study questionnaire validated to ask about experiences of childhood abuse, negligence, domestic violence, and household dysfunctions...
July 10, 2018: Clinical Rheumatology
https://www.readbyqxmd.com/read/29981076/geographic-variation-in-incidence-and-prevalence-rates-for-rheumatoid-arthritis-in-saskatchewan-canada-2001-2014
#11
Regina Taylor-Gjevre, Bindu Nair, Shan Jin, Jacqueline Quail
OBJECTIVES: To estimate and compare incidence/prevalence of rheumatoid arthritis (RA) in different geographic health regions and between urban/rural locations of residence within the province of Saskatchewan. METHODS: Saskatchewan Provincial Administrative Health Databases (2001-2014) were utilized as data sources. Two RA case-definitions were employed: (1) three physician billing diagnoses, at least one of which was submitted by a specialist (rheumatologist, general internist, or orthopedic surgeon) within 2 years; (2) one hospitalization diagnosis (ICD-9-CM code-714 and ICD-10-CA codes-M05, M06)...
April 16, 2018: Canadian Journal of Public Health. Revue Canadienne de Santé Publique
https://www.readbyqxmd.com/read/29979807/shoulder-arthroplasty-in-patients-with-rheumatoid-arthritis-a-population-based-study-examining-utilization-adverse-events-length-of-stay-and-cost
#12
Timothy S Leroux, Bryce A Basques, Bryan M Saltzman, Gregory P Nicholson, Anthony A Romeo, Nikhil N Verma
It has been suggested that the utilization of joint arthroplasty in patients with rheumatoid arthritis (RA) is decreasing; however, this observation is largely based upon evidence pertaining to lower-extremity joint arthroplasty. It remains unknown if these observed trends also hold true for shoulder arthroplasty. The purpose of this study is to utilize a nationally representative population database in the US to identify trends in the utilization of shoulder arthroplasty among patients with RA. Secondarily, we sought to determine the rate of early adverse events, length of stay, and hospitalization costs associated with RA patients undergoing shoulder arthroplasty and to compare these outcomes to those of patients without a diagnosis of RA undergoing shoulder arthroplasty...
June 2018: American Journal of Orthopedics
https://www.readbyqxmd.com/read/29958151/assessment-of-potentially-inappropriate-medications-in-elderly-according-to-beers-2015-and-stopp-criteria-and-their-association-with-treatment-satisfaction
#13
Stephanie Sakr, Souheil Hallit, Maria Haddad, Lydia Rabbaa Khabbaz
OBJECTIVE: To assess and compare, according to Beers and STOPP criteria, the frequency and causes of potentially inappropriate medications (PIMs) in elderly, as well as the relationship between PIMs use and patient's treatment satisfaction, evaluated using the Treatment Satisfaction Questionnaire for Medications (TSQM). METHOD: 350 patients (mean age = 73.49 years), taking a total of 1893 medications, were enrolled from community pharmacies. RESULTS: 6...
June 22, 2018: Archives of Gerontology and Geriatrics
https://www.readbyqxmd.com/read/29957465/1-25-oh-2-d-3-promotes-chondrocyte-apoptosis-and-restores-physical-function-in-rheumatoid-arthritis-through-the-nf-%C3%AE%C2%BAb-signal-pathway
#14
Run Tian, Xiaofang Li, Yue Li, Kunzheng Wang, Chunsheng Wang, Pei Yang
We explored the modulatory effect of 1,25(OH)2 D3 on chondrocytes and physical function in rats with RA and its mechanism underlying the regulation of NF-κB signal pathway. RA patients and healthy volunteers were selected. Sprague-Dawley (SD) rats were used to establish RA models. The paw volume of rats was estimated. Chondrocytes were isolated from RA rats. The protein levels in both cartilage tissues and chondrocytes were determined using western blotting. Apoptosis was evaluated using TUNEL assay. Serum levels of IL-1β, IL-6, IL-10 and IL-17 were measured by enzyme-linked immunosorbent assay (ELISA)...
June 26, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29955384/trends-in-hip-fracture-in-patients-with-rheumatoid-arthritis-results-from-the-spanish-national-inpatient-registry-over-a-17-year-period-1999-2015-trend-ar-study
#15
Ramón Mazzucchelli, Elia Pérez Fernandez, Natalia Crespí-Villarías, Javier Quirós-Donate, Alberto García Vadillo, María Espinosa, Marina Peña, Cristina Macía-Villa, Jose Luis Morell-Hita, Cristina Martinez-Prada, Virginia Villaverde, Inmaculada Morado Quiroga, Olalla Guzón-Illescas, Carmen Barbadillo, Manuel Fernández Prada, Hilda Godoy, Angela Herranz Varela, María Galindo Izquierdo, Gil Rodriguez Caravaca
Purpose: To analyse trends in hip fracture (HF) rates in patients with rheumatoid arthritis (RA) over an extended time period (17 years). Methods: This observational retrospective survey was performed by reviewing data from the National Surveillance System for Hospital Data, which includes more than 98% of Spanish hospitals. All hospitalisations of patients with RA and HF that were reported from 1999 to 2015 were analysed. Codes were selected using the Ninth International Classification of Diseases, Clinical Modification: ICD-9-CM: RA 714...
2018: RMD Open
https://www.readbyqxmd.com/read/29934747/associations-between-d3r-expression-in-synovial-mast-cells-and-disease-activity-and-oxidant-status-in-patients-with-rheumatoid-arthritis
#16
Li Xue, Xueyi Li, Qingping Chen, Juntao He, Yanying Dong, Jing Wang, Siyao Shen, Rui Jia, Quan Jin Zang, Ting Zhang, Ming Li, Yan Geng
Dopamine D3 receptor (D3R) on immune cells is involved in the pathogenesis of rheumatoid arthritis (RA). Mast cells (MCs) are currently identified as important effector cells in synovial inflammation of RA, but little is known about the role of D3R on synovial MCs in the pathogenesis of RA. Several inflammatory cells in the synovium induce reactive oxygen species (ROS) formation which are involved in the progression of RA. However, it is unclear whether D3R on synovial MCs is related to the levels of ROS in RA patients...
June 22, 2018: Clinical Rheumatology
https://www.readbyqxmd.com/read/29932968/time-trends-in-the-prevalence-of-cancer-and-non-cancer-diseases-among-older-u-s-adults-medicare-based-analysis
#17
Igor Akushevich, Julia Kravchenko, Arseniy P Yashkin, Anatoliy I Yashin
Longer lifespan is accompanied by a larger number of chronic diseases among older adults. Because of a growing proportion of older adults in the U.S., this brings the problem of age-related morbidity to the forefront as a major contributor to rising medical expenditures. We evaluated 15-year time trends (from 1998 to 2013) in the prevalence of 48 acute and chronic non-cancer diseases and cancers in older U.S. adults aged 65+ and estimated the annual percentage changes of these prevalence trends using SEER-Medicare and HRS-Medicare data...
June 19, 2018: Experimental Gerontology
https://www.readbyqxmd.com/read/29897007/an-economic-evaluation-of-tofacitinib-treatment-in-rheumatoid-arthritis-after-methotrexate-or-after-1-or-2-tnf-inhibitors-from-a-u-s-payer-perspective
#18
Lindsay Claxton, Matthew Taylor, Arif Soonasra, Jeffrey A Bourret, Robert A Gerber
BACKGROUND: Treatment cycling with biologic disease-modifying anti-rheumatic drugs, such as tumor necrosis factor inhibitors (TNFi), is common among patients with rheumatoid arthritis (RA) and can result in reduced clinical efficacy and increased economic burden. Tofacitinib is an oral Janus kinase inhibitor for the treatment of RA. OBJECTIVE: To evaluate and compare the economic effect of tofacitinib 5 mg twice daily (BID) treatment directly after methotrexate (MTX) in the MTX-inadequate responder population, or after MTX and 1 TNFi (adalimumab [ADA] or etanercept [ETN]) or 2 TNFi (ADA and ETN) in TNF-inadequate responder patients with RA, from a U...
June 13, 2018: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/29876690/differences-in-clinical-pneumocystis-pneumonia-in-rheumatoid-arthritis-and-other-connective-tissue-diseases-suggesting-a-rheumatoid-specific-interstitial-lung-injury-spectrum
#19
Kota Shimada, Kyoko Yokosuka, Takahiro Nunokawa, Shoji Sugii
To compare Pneumocystis pneumonia (PCP) in patients with rheumatoid arthritis (RA) with PCP in patients with non-RA connective tissue diseases (CTDs) in order to clarify the characteristics of the former. We extracted consecutive patients satisfying the following criteria for "clinical PCP": (1) positive plasma β-D-glucan, (2) PCP-compatible computed tomography findings of the lung, and (3) successful treatment with antipneumocystic antibiotics. Patients who underwent methylprednisolone "pulse" therapy or sufficient antibiotics to cure bacterial pneumonia were excluded...
June 6, 2018: Clinical Rheumatology
https://www.readbyqxmd.com/read/29857511/sphingolipidomic-profiling-of-rat-serum-by-uplc-q-tof-ms-application-to-rheumatoid-arthritis-study
#20
Fanghui Qu, Hongyang Zhang, Min Zhang, Ping Hu
Sphingolipids (SPLs) are biologically important molecules, but the structural diversity and complexity of SPLs brings significant analytical challenges for their study. In this paper, we have developed an UPLC-Q-TOF-MS-based sphingolipidomic approach for the comprehensive identification and quantification of SPLs in rat serum. A total of 120 SPLs covering seven subcategories were identified for the first time. Method validations including linearity, sensitivity, reproducibility, and recovery were also evaluated...
May 31, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
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