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Trend rheumatoid arthritis

Shuang Lv, HuiZhen Fan, Jiang Li, Hui Yang, Jing Huang, XiaoMing Shu, Lu Zhang, Yuan Xu, Xiaoya Li, Jieyu Zuo, Cheng Xiao
Objective: Analysis of the relationship between single nucleotide polymorphisms (SNPs) and outcomes of methotrexate (MTX) therapy for rheumatoid arthritis (RA) in China. Materials and Methods: TYMS 28 bp VNTR (rs34743033), MTHFR [677C>T (rs1801133) and 1298A>C (rs1801131)], ATIC 347C>G (rs2372536), MTR A2756G (rs1805087), and MTRR 66A>G (rs1801394) enzyme proteins may be related to the outcomes of MTX therapy, according to our previous meta-analysis. A total of 162 patients with RA were included in our study...
2018: Frontiers in Pharmacology
Nasim Ahmed Khan, Chau L Nguyen, Talha Khawar, Horace Spencer, Karina D Torralba
Objectives: To examine the prevalence, types and temporal trends of reported financial conflicts of interest (FCOIs) among authors of drug therapy randomized controlled trials (RCTs) for RA and their association with study outcomes. Methods: We identified original, non-phase 1, parallel-group, drug therapy RA RCTs published in the years 2002-03, 2006-07, and 2010-11. Two investigators independently obtained trial characteristics data. Authors' FCOIs were classified as honoraria/consultation fees receipt, employee status, research grant, and stock ownership...
December 10, 2018: Rheumatology
Stylianos Panopoulos, Maria Tektonidou, Alexandros A Drosos, Stamatis-Nick Liossis, Theodoros Dimitroulas, Alexandros Garyfallos, Lazaros Sakkas, Dimitrios Boumpas, Paraskevi V Voulgari, Dimitrios Daoussis, Konstantinos Thomas, Georgios Georgiopoulos, Georgios Vosvotekas, Dimitrios Vassilopoulos, Petros P Sfikakis
BACKGROUND: Comorbidities are common in chronic systemic connective tissue diseases and are associated with adverse outcomes, increased morbidity and mortality. Although the prevalence of comorbidities has been well-studied in isolated diseases, comparative studies between different autoimmune diseases are limited. In this study, we compared the prevalence of common comorbidities between patients with systemic sclerosis (SSc) and patients with rheumatoid arthritis (RA). METHODS: Between 2016 and 2017, 408 consecutive patients with SSc, aged 59 ± 13 years (87% women), were matched 1:1 for age and gender with 408 patients with RA; mean disease duration was 10 ± 8 and 9 ± 8 years, respectively...
December 4, 2018: Arthritis Research & Therapy
Divya N V Challa, Zoran Kvrgic, Cynthia S Crowson, Eric L Matteson, Thomas G Mason, Clement J Michet, Daniel E Schaffer, Kerry A Wright, John M Davis
OBJECTIVE: The objective was to identify longitudinal predictors of discordance between patients with rheumatoid arthritis (RA) and their health care providers, where patient global assessment of disease activity is substantially higher than provider global assessment. METHODS: This retrospective case-control study included 102 cases with positive discordance (ie, ≥25 mm between patient and provider global assessments) and 102 controls without discordance who were matched for age, sex, RA duration, and Clinical Disease Activity Index (CDAI)...
November 30, 2018: Arthritis Care & Research
Kazuha Kizaki, Fumiharu Yamashita, Noboru Funakoshi, Daisuke Mori, Kiyoshi Otsuka, Megumi Itoi
Infliximab shows drastic efficacy for controlling inflammation in rheumatoid arthritis (RA), though the ideal dose of infliximab to keep suppressing inflammation has not yet been identified. Recently, it has been evidenced that the minimum trough serum infliximab levels required for suppressing inflammation are greater than 1 µg/mL. This cross-sectional study was designed to identify the minimum dosage of infliximab for maintaining serum infliximab levels greater than 1 µg/mL. Thirty seven RA patients were enrolled in this study and they were divided into two groups (high-infliximab vs...
2018: Biological & Pharmaceutical Bulletin
Eric R Wagner, Michelle J Chang, Kathryn M Welp, Muriel J Solberg, Tyler J Hunt, Jarret M Woodmass, Laurence D Higgins, Jon J P Warner
BACKGROUND: Since the approval of reverse shoulder arthroplasty (RSA) in 2004, the use of shoulder arthroplasty increased dramatically. Although the success of RSA in the revision setting has been demonstrated, there remains a paucity of studies examining the epidemiology of RSA in revision arthroplasty. This study describes trends of revision arthroplasty during the "era of the reverse," from 2005 through 2016. METHODS: In a multicenter retrospective analysis, we analyzed 274 revision shoulder arthroplasties converted to a RSA (n = 182), anatomic total shoulder arthroplasty (TSA, n = 68), or hemiarthroplasty (n = 24) from 2005 to 2016...
November 28, 2018: Journal of Shoulder and Elbow Surgery
Rongqiang Zhang, Xiaoli Yang, Jing Wang, Lixin Han, Aimin Yang, Jie Zhang, Dandan Zhang, Baorong Li, Zhaofang Li, Yongmin Xiong
The present study aimed to identify potential novel biomarkers in synovial tissue obtained from patients with Rheumatoid Arthritis (RA) and Osteoarthritis (OA) for differential diagnosis. The genome‑wide expression profiling datasets of synovial tissues from RA and OA cohorts, including GSE55235, GSE55457 and GSE55584 datasets, were retrieved and used to identify differentially expressed genes (DEGs; P<0.05; false discovery rate <0.05 and Fold Change >2) between RA and OA using R software. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analyses of DEGs were performed to determine molecular and biochemical pathways associated with the identified DEGs, and a protein‑protein interaction (PPI) network of the DEGs was constructed using Cytoscape software...
November 20, 2018: Molecular Medicine Reports
Yvonne C Lee, Joel Kremer, Hongshu Guan, Jeffrey Greenberg, Daniel H Solomon
OBJECTIVES: The opioid epidemic is a major public health concern. However, little is known about opioid use among rheumatoid arthritis (RA) patients. We examined trends in chronic opioid use in RA patients from 2002-2015 and identified clinical predictors. METHODS: RA patients were identified from the Corrona registry. Opioid use was ascertained from surveys obtained at clinical visits, as often as every 3 months. Chronic opioid use was defined as any opioid use reported during ≥2 consecutive study visits...
November 26, 2018: Arthritis & Rheumatology
Wenjia Sun, Lizhen Tian, Lichun Jiang, Songzhao Zhang, Meiju Zhou, Jianing Zhu, Jing Xue
OBJECTIVE: To determine the serum levels of Dickkopf-1 (DKK-1) and sclerostin, as well as their correlations with the structural damage assessed by modified stoke ankylosing spondylitis spine score (mSASSS) and the disease activity evaluated by ankylosing spondylitis disease activity score (ASDAS) in patients with ankylosing spondylitis (AS). METHODS: Eighty-eight AS patients, 26 rheumatoid arthritis (RA) patients, and 26 age- and gender-matched healthy controls (HC) were collected from rheumatic clinic of the Second Affiliated Hospital of Zhejiang University, School of Medicine, between March 2015 and July 2015...
November 15, 2018: Clinical Rheumatology
Di Fu, Chuyin Xiao, Yingying Xie, Jianquan Gao, Shanhui Ye
Rheumatoid arthritis synovial fibroblasts (RASFs) play a key role in the pathogenesis of rheumatoid arthritis (RA). This study was aimed to investigate the effects of miR-3926 on the biological activities of RASFs. The results showed that miR-3926 was significantly down-regulated in RASFs and RA synovial tissue. Overexpression of miR-3926 significantly inhibited RASFs proliferation and decreased the secretion of inflammatory cytokines including TNF-α, IL-1β and IL-6 in RASFs. TLR5 was identified to be a direct target of miR-3926...
November 6, 2018: Gene
Zhiyuan Sun, Tao Wei, Xiaoying Zhou
Rheumatoid arthritis (RA) is an autoimmune disease and characterized by the excessive cell proliferation, abnormal cell cycle of lymphocytes and synovial cells. The therapeutic effects of curcumin in active RA patients were reported, but limited by its insolubility and rapid systemic elimination. Dimethyl curcumin (DiMC) is a metabolically stable analogue of curcum with anti-inflammatory property. In this study, liposomes encapsulated dimethyl curcumin (Lipo-DiMC) was prepared to improve the bioavailability and metabolic-stability; collagen induced arthritis (CIA) rat model was employed to investigate the effects of Lipo-DiMC treatments during CIA progress...
December 2018: International Immunopharmacology
Elizabeth Mollard, Kaleb Michaud
BACKGROUND: Patient outcomes are improved and the burden to the health care system is reduced when individuals are active self-managers of their own health. There is a need for technology that facilitates self-management of rheumatoid arthritis (RA) and can reduce the number of patient visits, promptly identify treatment needs, and reduce the costs associated with poor RA management. A mobile app named LiveWith Arthritis (eTreatMD, Vancouver, BC) has been developed that allows patients with RA to use their mobile device to regularly collect self-management data and to take objective measurements of the impact of RA on their finger joints using optical imaging technology...
October 29, 2018: JMIR MHealth and UHealth
Saeed Akhlaghi, Maryam Sahebari, Mahmoud Mahmoodi, Mehdi Yaseri, Mohammad Ali Mansournia, Houshang Rafatpanah, Hojjat Zeraati
Purpose: One of the most important long-term side effects of therapy for rheumatoid arthritis (RA) is the elevation of liver function tests, with earlier studies reporting an elevation of more than 1× the upper limit of normal (>1 × ULN). The current study expands the literature by comparing the trends of transaminase changes caused by conventional and biologic disease-modifying antirheumatic drugs (DMARDs). Patients and methods: The drug categories examined were methotrexate (MTX) and all other nonbiologic DMARDs...
2018: Therapeutics and Clinical Risk Management
Kosuke Shabana, Nami Okamoto, Yuko Sugita, Keisuke Shindo, Takuji Murata, Hiroshi Tamai, Kenta Fujiwara
OBJECTIVE: We researched the findings of musculoskeletal ultrasound sonography (MSUS) on primary Sjogren's syndrome in childhood (pSS-C) with articular manifestations. The correlation of rheumatoid factor (RF) and anti-cyclic citrullinated peptide antibody (ACPA) were investigated to evaluate the usefulness of MSUS on their articular prognosis. METHOD: The objective patients are pSS-C cases who visited our hospital complaining joint pain and/or joint swelling and for whom MSUS was performed...
October 5, 2018: Modern Rheumatology
K Chatzidionysiou, G Lukina, C Gabay, M L Hetland, E M Hauge, K Pavelka, D Nordström, H Canhão, M Tomsic, Z Rotar, E Lie, T K Kvien, R F van Vollenhoven, S Saevarsdottir
OBJECTIVES: To investigate whether smoking habits predict response to rituximab (RTX) in rheumatoid arthritis (RA). METHOD: We included patients from the CERERRA international cohort receiving the first treatment cycle with available smoking status (n = 2481, smokers n = 528, non-current smokers n = 1953) and at least one follow-up visit. Outcome measures were change in Disease Activity Score based on 28-joint count (ΔDAS28) and European League Against Rheumatism (EULAR) good response at 6 months, with non-current smokers as the referent group...
September 27, 2018: Scandinavian Journal of Rheumatology
Paula Muilu, Vappu Rantalaiho, Hannu Kautiainen, Lauri Juhani Virta, Johan Gunnar Eriksson, Kari Puolakka
To explore the trends in the incidence of idiopathic inflammatory rheumatic diseases (IIRDs) after the turn of the millennium. From a nationwide register maintained by the Social Insurance Institution of Finland, we collected all adult patients with IIRDs granted a new special reimbursement for anti-rheumatic drugs between 2000 and 2014. Temporal trends in the incidences of various IIRDs were estimated in three 5-year intervals. A total of 58,405 adult patients were identified. Between 2000-2004 and 2010-2014, the age-adjusted incidence rate of IIRDs increased from 114 to 116/100000 [incidence rate ratio (IRR) 1...
September 26, 2018: Clinical Rheumatology
Michelle S M A Damen, Kiki Schraa, Lieke Tweehuysen, Alfons A den Broeder, Mihai G Netea, Calin D Popa, Leo A B Joosten
About 60% of RA patients don't achieve good response with biological disease-modifying anti-rheumatic drugs bDMARD treatment (including TNF inhibitors, TNFi's). Previously, a link between TNFα and interleukin (IL)-32 was reported in RA. However, the exact mechanism linking IL-32 to response to treatment as not been studied yet. Therefore, we explored the influence of a promoter single nucleotide polymorphism (SNP) rs4786370 in IL-32 on clinical responsiveness to TNFi's in RA patients, potentially serving as new biomarker in RA...
September 19, 2018: Scientific Reports
Chin-An Yang, Ju-Pi Li, Ju-Chen Yen, I-Lu Lai, Yu-Chen Ho, Yu-Chia Chen, Joung-Liang Lan, Jan-Gowth Chang
Monocytes/macrophages are important in orchestrating inflammatory responses. However, knowledge of the long noncoding RNA (lncRNA) regulation of monocytic cell differentiation and diseases remains limited. We aimed to elucidate the role of the 17 kb lncRNA noncoding transcript in T cells ( NTT ) in monocyte functions. Knockdown and chromatin immunoprecipitation (ChIP) assays in THP-1 cells (human monocytic leukemia cell line) revealed that NTT is regulated by the monocyte key transcription factor C/EBPβ and that it binds to the promoter of nearby gene PBOV1 via hnRNP-U...
September 18, 2018: International Journal of Molecular Sciences
J Holinka
There is a trend towards a reduction in joint-preserving hip surgery, such as synovectomy and total hip joint replacement in rheumatic patients. This is mostly due to the success of biological disease-modifying antirheumatic drugs (bDMARD) in systemic anti-rheumatic therapy. The results of hip surgery in rheumatic patients are comparable to those in non-rheumatic patients, except for prosthetic joint infections, which are higher in patients with rheumatoid arthritis. Especially in hip surgery there was a big evolution in the last few years including a broad range of minimally invasive surgical methods, such as hip arthroscopy, mini-open hip surgery and minimally invasive hip arthroplasty with bone preservation or short femoral shafts...
December 2018: Zeitschrift Für Rheumatologie
Ellenor Mittendorfer-Rutz, Syed Rahman, Antti Tanskanen, Maila Majak, Juha Mehtälä, Fabian Hoti, Erik Jedenius, Dana Enkusson, Amy Leval, Jan Sermon, Heidi Taipale, Jari Tiihonen
Background: The study aimed to (1) compare the risk of health care use, adverse health status, and work productivity loss of parents of patients with schizophrenia to parents of patients with multiple sclerosis (MS), rheumatoid arthritis (RA), epilepsy, and healthy controls; and (2) evaluate such outcome measures while considering disease severity of schizophrenia. Methods: Based on linkage of Swedish registers, at least one parent was included (n = 18215) of patients with schizophrenia (information 2006-2013, n = 10883)...
September 3, 2018: Schizophrenia Bulletin
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