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Perforator imaging

Luciano Serpe, Bruno Vilela Muniz, Cleiton Pita Dos Santos, Camila Batista da Silva, Maria Cristina Volpato, Francisco Carlos Groppo, Renata Fonseca Vianna Lopez, Michelle Franz-Montan
The use of permeation enhancers such as microneedles (MNs) to increase drug penetration across intraoral mucosa has increased in recent years. Permeation studies, commonly performed using vertical diffusion cells, are a well-established way to preview formulations and enhance their performance during the development stage. However, to our knowledge, the existing intraoral mucosa barrier models do not permit permeation using MNs-pretreated mucosa, due to their insufficient thickness. Therefore, the objective of this study was to develop a barrier model using thick palate tissues to perform in vitro permeation studies, with physical enhancement of the permeability of intraoral mucosa by pretreatment with MNs...
December 13, 2018: Journal of Pharmaceutical Sciences
Min-Woo Chung, Sang-Yoon Ha, Jung-Ho Choi, Hyuk-Jin Park, Dae-Seong Myung, Sung-Bum Cho, Wan-Sik Lee, Jin-Woong Kim, Hyung-Hoon Oh, Young-Eun Joo
RATIONALE: Radiofrequency ablation (RFA) is a safe and effective local treatment modality with a low complication rate and is commonly used to treat hepatocellular carcinoma (HCC). The clinical outcome of RFA may be closely related to the location, size, and shape of index tumors, and major complications, including hemorrhage, liver abscess, infarction, visceral organ perforation, hemothorax, pneumothorax, tumoral seeding, and hepatic failure. Cardiac tamponade is a rare and serious life-threatening complication associated with RFA...
December 2018: Medicine (Baltimore)
Sang Bum Kim, John M Rhee, Gi Soo Lee, Hee Young Lee, Taehyung Kim, Yougun Won
The cortical bone trajectory (CBT) screw technique yields effective mechanical and clinical results, improving the holding screw strength with a less invasive exposure. Accurate and safe screw placement is crucial. A patient-specific drill template with a preplanned trajectory was considered a promising solution; however, it is critical to assess the efficacy and safety of this technique. This study aims to evaluate the accuracy of patient-specific computed tomography (CT)-based rapid prototype drill guide templates for the CBT technique...
December 2018: Techniques in Orthopaedics: TIO
Naoki Akizue, Tomoaki Matsumura, Daisuke Maruoka, Kentaro Ishikawa, Dao Viet Hang, Kenichiro Okimoto, Keiko Saito, Tomoo Nakagawa, Makoto Arai, Naoya Kato
Background and study aims  Endoscopic submucosal dissection (ESD) requires advanced skills to perform safely without complications. The current study evaluated the usefulness of a novel three-dimensional (3D) imaging system in ESD using porcine stomachs. Methods  Four endoscopists (two trainees and two experts) performed eight ESD procedures using both 3D and 2D images. The usefulness of 3D image versus 2D image was evaluated by visibility and procedure time. In addition, occurrence of eyestrain and dizziness in 3D image was assessed...
December 2018: Endoscopy International Open
Daniele Tognetto, Chiara De Giacinto, Alberto Armando Perrotta, Tommaso Candian, Alessandro Bova, Silvia Rinaldi, Gianluca Turco
Purpose: To compare the capsule edges ultrastructure obtained by two femtosecond laser-assisted cataract surgery (FLACS) platforms and manual continuous curvilinear capsulorhexis (CCC) using scanning electron microscopy (SEM). Setting: Eye Clinic, University of Trieste, Italy. Design: Experimental comparative study. Methods: 150 anterior capsules were collected and divided into three groups as follows: Group 1 (50 capsules) obtained with manual CCC, Groups 2 and 3 (each with 50 capsules) obtained with the Catalys Laser and the LenSx Laser, respectively...
2018: Journal of Ophthalmology
Brit Long, Jennifer Robertson, Alex Koyfman
BACKGROUND: Small bowel obstruction (SBO) is a commonly diagnosed disease in the emergency department (ED). Recent literature has evaluated the ED investigation and management of SBO. OBJECTIVE: This review evaluates the ED investigation and management of adult SBO based on the current literature. DISCUSSION: SBO is most commonly due to occlusion of the small intestine, resulting in fluid and gas accumulation. This may progress to mucosal ischemia, necrosis, and perforation...
December 6, 2018: Journal of Emergency Medicine
C Koç, K Kamburoğlu, G Sönmez, F Yılmaz, O Gülen, S Karahan
AIM: To assess observer performance in detecting endodontic complications using three different CBCT units with and without the application of artefact reduction modes. METHODOLOGY: The study involved 40 freshly extracted human mandibular teeth (n=10 per group) and divided randomly into four endodontic complication groups. Group 1) Instrument fracture; Group 2) Strip perforation; Group 3) Canal underfilling; Group 4) Canal overfilling. Images of each tooth were obtained using three different CBCT units offering artefact reduction algorithms: the ProMax 3D Max, the Pax Flex 3D, and the Dentri S...
December 2, 2018: International Endodontic Journal
Jiagang Han, Zhenjun Wang, Yong Dai, Xiaorong Li, Qun Qian, Guiying Wang, Guanghui Wei, Weigen Zeng, Liangang Ma, Baocheng Zhao, Yanlei Wang, Kaiyan Yang, Zhao Ding, Xuhua Hu
OBJECTIVE: To evaluate the safety and feasibility of neoadjuvant chemotherapy prior elective surgery following self-expanding metallic stents (SEMS) for complete obstructive left hemicolon cancer. METHODS: This prospective, multicenter, open-labelled trial was approved by the Ethics Committee of Beijing Chaoyang Hospital, Capital Medical University(2016-ke-161-1) and registered in (NCT02972541). INCLUSION CRITERIA: (1)age between 18 and 75 years old;(2) adenocarcinoma confirmed by pathology;(3) left hemicolon cancer confirmed by clinical manifestations and imaging examinations with the distance to anal verge > 15 cm; (4) resectable cancer evaluated by imaging examination without distant metastasis; (5) Eastern Cooperative Oncology Group (ECOG) score ≤ 1 or Karnofsky Performance Scale (KPS) > 70, indicating tolerance of neoadjuvant chemotherapy and operation; (6) absence of chemotherapy or radiotherapy within past six months; (7) bone marrow system and hepatorenal function: hemoglobin ≥ 90 g/L, neutrophil ≥ 1...
November 25, 2018: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
Lele Zhang, Haiyi Wang
Both malignant tumors derived from gastrointestinal tract and metastasis from peritoneal spread, hematogenous dissemination and lymph node can lead to acute abdomen. Such acute abdomen patients have poor prognosis, high mortality, and complex clinical manifestations. It is difficult to make a correct diagnosis in clinical practice. Recent studies show that gastrointestinal tumors are associated with clinical emergency. Malignant gastrointestinal tumors mostly result in obstruction, so upper gastrointestinal contrast for gastric cancer and post-enhanced CT for colon cancer are recommended; gastrointestinal stromal tumors usually cause bleeding, so computed tomography angiography (CTA) is the first choice for examination; primary gastrointestinal lymphoma tends to cause perforation and usually occurs in small intestine, so CT is the first examination for patients with ischemic acute abdomen, and post-enhanced CT is essential to exclude small intestine carcinoid because of its rising incidence in recent years...
November 25, 2018: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
Dincer Altinel, Burcu Biltekin, Merdan Serin, Ugur Sahin, Muzaffer Altindas
Background: In this study, we investigated the subdermal and perforator delay phenomena as a method to improve flap survival. Materials and Methods: In this experimental study, we used 24 rats in three groups. In the control group, the dorsal flaps were elevated and reinserted back to their place. In the experimental groups, we practiced the delay phenomena with two different techniques. In the first experimental group, cranial and lateral side incisions were performed; however, the flaps were not cut-off from the underlying fascia...
May 2018: Indian Journal of Plastic Surgery: Official Publication of the Association of Plastic Surgeons of India
Jennifer L Philip, Megan C Saucke, Jessica R Schumacher, Sara Fernandes-Taylor, Jeffrey Havlena, Caprice C Greenberg, Angela M Ingraham
BACKGROUND: Transferred emergency general surgery (EGS) patients have increased morbidity, mortality, and costs, yet little is known about the characteristics of such transfers. Increasing specialization and a decreasing general surgery workforce have led to concerns about access to care, which may lead to increased transfers. We sought to evaluate the reasons for and timing of transfers for EGS diagnoses. METHODS: We performed a retrospective medical record review of patients transferred to a tertiary academic medical center between January 4, 2014 and March 31, 2016 who had an EGS diagnosis (bowel obstruction, appendicitis, cholecystitis/cholangitis/choledocholithiasis, diverticulitis, mesenteric ischemia, perforated viscus, or postoperative surgical complication)...
January 2019: Journal of Surgical Research
Long Wang, Hongqiang Wu, Chen Lin, Zihuai Huang, Renhao Jiang, Xianyao Tao, Jian Ding, Weiyang Gao
BACKGROUND: Necrosis of propeller flaps is a problem in clinical practice. This study was performed to investigate the effects of pedicle torsion on dynamic perforasome survival using a multiterritory perforator flap model in rats. METHODS: Intercostal artery perforator flaps (IC flaps) containing two adjacent dynamic perforasomes were applied to both sides of the dorsum in 15 rats. The IC vessels were dissected carefully under 10 × magnification. A 360° arc of pedicle torsion was applied to the right IC flaps, which comprised the rotary group...
November 2, 2018: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
Kyle S Gabrick, Amandine Godier-Furnemont, Fouad Chouairi, Tomer Avraham, Michael Alperovich
BACKGROUND: CT angiography (CTA) can be performed pre-operatively for perforator mapping in autologous breast reconstruction. The full impact of incidental CTA findings on breast reconstruction remains unclear. METHODS: CTAs were reviewed for all patients who underwent imaging prior to autologous breast reconstruction at Yale New Haven Hospital from 2013-2018. CTA findings and all resulting follow-up imaging, treatment, and change in management were catalogued. Our findings were compared to other published reports in the literature to better categorize the impact of CTA findings on patient care...
November 22, 2018: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
Ragda Abdalla-Aslan, Silvina Friedlander-Barenboim, Doron J Aframian, Alexander Maly, Chen Nadler
BACKGROUND AND OVERVIEW: Cone-beam computerized tomographic (CBCT) imaging is increasingly used in the maxillofacial region for various purposes. The volumetric dataset created by means of CBCT increases the possibility of detecting incidental findings. CASE DESCRIPTION: In this case report, the authors describe an otherwise healthy 45-year-old man who was referred from the Sjogren's Syndrome Center in Jerusalem, Israel, for bilateral parotid CBCT sialographic imaging owing to xerostomia lasting for 4 months...
December 2018: Journal of the American Dental Association
Motomi Arai
We present the unique case of a patient with lumbosacral radiculoplexus neuropathy (LRPN) and a small intramedullary lesion, probably an infarction, in the spinal cord. A previously healthy 58-year-old female developed acute severe pain involving the entire right lower limb, followed by weakness of the right lower limb a few hours later. The patient could not walk and was referred to our clinic. The patient reported no sphincter symptoms. Examination of the cranial nerves and upper limbs revealed no abnormalities...
November 29, 2018: Rinshō Shinkeigaku, Clinical Neurology
(no author information available yet)
Superficial siderosis of the central nervous system (SSCNS) is an uncommon and often unrecognized disorder that results from recurrent and persistent bleeding into the subarachnoid space. Currently, there is no effective treatment for SSCNS. The identification and surgical resolution of the cause of bleeding remains the most reliable method of treatment, but the cause of bleeding is often not apparent. The identified sources of recurrent bleeding have typically included neoplasms, vascular malformations, brachial plexus or nerve root injury or avulsion, and previous head and spinal surgery...
October 1, 2018: Journal of Neurosurgery. Spine
Reagon Daniel Ramiah, Basalingappa Navadgi
Anterior cortical penetration of distal femora when using long gamma nails is well established. To avoid this complication, using the appropriate entry point, a nail with a smaller radius of curvature, and intraoperative imaging is suggested. Despite this, there are times when the guidewire or the nail can abut or even perforate the anterior cortex. This is more likely to occur in patients with scalloped anterior distal femora and increased femoral anterior bowing. The authors overcome this potential problem during surgery by using a bent-tip guidewire...
November 26, 2018: Orthopedics
Gözde Derindağ, Özkan Miloğlu, Muhammed Akif Sümbüllü
Buccal bifurcation cyst (BBC) is an uncommon inflammatory odontogenic cyst that generally occurs at the buccal region of the permanent mandibular first molars in children aged 6-8 years. The diagnosis of BBC cannot be made from the histopathologic features; therefore, diagnosis is primarily based on specific clinical and radiographic findings. In this case report, we present the clinical and radiological findings, including ultrasonography (USG) and cone-beam computed tomography (CBCT) images, of a 10-year-old boy who was referred with a complaint of swelling on the lower right jaw...
July 26, 2018: Oral Radiology
Shuzo Yamamoto, Tatsushi Mutoh, Kazumasu Sasaki, Tomoko Mutoh, Yasuyuki Taki
Early brain injury and related cardiac consequences play a key role in the devastating outcomes after subarachnoid hemorrhage (SAH). We reported that rapamycin exerts neuroprotection against cortical hypoxia early after SAH, but its mechanism is poorly understood. This in vivo study aimed to determine the potential role of the transcription factor STAT3 in the rapamycin-mediated neuroprotection in a mouse model of SAH. Forty C57BL/6 N mice were treated with an intracerebroventricular injection of rapamycin or vehicle (control) given after SAH induction by a filament perforation method, with or without STAT3 (Stattic) or ERK (PD98059) inhibitor pretreatment...
November 24, 2018: Brain Research Bulletin
Carine Bourassa, Yara K Hosein, Steven I Pollmann, Khadry Galil, Richard N Bohay, David W Holdsworth, Ali Tassi
INTRODUCTION: This experiment was undertaken to assess the primary stability of orthodontic miniscrews inserted at different sites in human cadaveric palatal bone for temporary skeletal anchorage, and to determine the effect of bone quality and quantity on their primary stability using microcomputed tomography imaging. METHODS: A total of 10 cadaveric maxillary hard palates were used for insertion of 130 orthodontic miniscrews (VectorTAS; Ormco, Orange, Calif; length, 6 mm; diameter, 1...
December 2018: American Journal of Orthodontics and Dentofacial Orthopedics
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