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JOURNAL ARTICLE
J Hernandez, J-M Lina, J Dubé, A Lafrenière, J-F Gagnon, J-Y Montplaisir, R B Postuma, J Carrier
STUDY OBJECTIVES: Idiopathic/isolated REM-sleep behavior disorder (iRBD) often precedes the onset of synucleinopathies. Here, we investigated whether baseline resting-state EEG advanced spectral power and functional connectivity differ between iRBD patients who converted towards a synucleinopathy at follow-up and those who did not. METHODS: Eighty-one participants with iRBD (66.89±6.91 years) underwent a baseline resting-state EEG recording, a neuropsychological assessment and a neurological examination...
March 18, 2024: Sleep
#22
JOURNAL ARTICLE
Minji Lee, Tong Keon Kim, Jung Kyung Hong, In-Young Yoon
STUDY OBJECTIVES: Despite its widespread use in patients with isolated rapid eye movement sleep behavior disorder (iRBD), the cognitive effect of clonazepam is uncertain. This study aimed to investigate effect of cumulative clonazepam on cognitive function in patients with iRBD. METHODS: Demographic characteristics, baseline cognitive test, and most recent cognitive test information were collected retrospectively. Based on cumulative clonazepam doses, patients were classified into four subgroups: group 1 < 365 mg (1 mg * 1 year); 365 mg ≤ group 2 < 1,095 mg (1 mg * 3 years); 1,095 mg ≤ group 3 < 2,190 mg (1 mg * 6 years); and group 4 ≥ 2,190 mg...
March 18, 2024: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
#23
REVIEW
Milad Najafzadeh, Fatemeh Mohammadian, Sara Mirabian, Zohre Ganji, Hossein Akbari, Masoud Rezaie, Esmaeil Ranjbar, Hoda Zare, Shahrokh Nasseri, Luigi Ferini-Strambi
Rapid eye movement behavior disorder (RBD) is a parasomnia characterized by the loss of skeletal muscle atonia during the rapid eye movement (REM) sleep phase. On the other hand, idiopathic RDB (iRBD) is considered the prelude of the various α-synucleinopathies, including Parkinson's disease (PD), dementia with Lewy bodies and multiple system atrophy. Consequently, over 40% of patients eventually develop PD. Recent neuroimaging studies utilizing structural magnetic resonance imaging (s-MRI), diffusion-weighted imaging (DWI), and functional magnetic resonance imaging (fMRI) with graph theoretical analysis have demonstrated that patients with iRBD and Parkinson's disease have extensive brain abnormalities...
March 2024: Brain and Behavior
#24
REVIEW
Hayder M Al-Kuraishy, Ali I Al-Gareeb, Ali K Albuhadily, Yaser Hosny Ali Elewa, Ammar Al-Farga, Faisal Aqlan, Mahmoud Hosny Zahran, Gaber El-Saber Batiha
BACKGROUND: Parkinson's disease (PD) is a progressive neurodegenerative brain disease due to degeneration of dopaminergic neurons (DNs) presented with motor and non-motor symptoms. PD symptoms are developed in response to the disturbance of diverse neurotransmitters including γ-aminobutyric acid (GABA). GABA has a neuroprotective effect against PD neuropathology by protecting DNs in the substantia nigra pars compacta (SNpc). It has been shown that the degeneration of GABAergic neurons is linked with the degeneration of DNs and the progression of motor and non-motor PD symptoms...
March 2024: CNS Neuroscience & Therapeutics
#25
JOURNAL ARTICLE
Dongling Zhang, Liche Zhou, Chenxi Lu, Tao Feng, Jun Liu, Tao Wu
BACKGROUND AND OBJECTIVES: Cognitive impairments are common in idiopathic REM sleep behavior disorder (iRBD), in which the cholinergic degeneration of nucleus basalis of Meynert (NBM) may play an important role. However, the progressive changes of NBM, the relationship between progressive NBM degeneration and progression of cognitive impairments, and whether degeneration of the NBM can predict cognitive decline in patients with iRBD remain unclear. This study aimed to investigate the cross-sectional and longitudinal microstructural alterations in the NBM of patients with iRBD using free-water imaging and whether free water in the NBM is related to cognitive, mood, and autonomic function...
April 9, 2024: Neurology
#26
REVIEW
Jessi L Keavney, Soania Mathur, Karlin Schroeder, Ray Merrell, Sergio A Castillo-Torres, Virginia Gao, Grace F Crotty, Michael A Schwarzschild, John M Poma
The movement toward prevention trials in people at-risk for Parkinson's disease (PD) is rapidly becoming a reality. The authors of this article include a genetically at-risk advocate with the LRRK2 G2019 S variant and two patients with rapid eye movement sleep behavior disorder (RBD), one of whom has now been diagnosed with PD. These authors participated as speakers, panelists, and moderators in the "Planning for Prevention of Parkinson's: A Trial Design Forum" hosted by Massachusetts General Hospital in 2021 and 2022...
March 14, 2024: Journal of Parkinson's Disease
#27
JOURNAL ARTICLE
Kyoungeun Park, Jung Hwan Shin, Jung-Ick Byun, El Jeong, Han-Joon Kim, Ki-Young Jung
STUDY OBJECTIVES: This study aimed to identify electroencephalographic (EEG) spectro-spatial covariance patterns associated with phenoconversion in isolated rapid eye movement sleep behavior disorder (iRBD) patients and explore their longitudinal trajectories within α-synucleinopathies. METHODS: We assessed 47 participants, including 35 iRBD patients and 12 healthy controls (HC), through baseline eye-closed resting EEGs. iRBD patients underwent follow-up EEG assessments and 18 iRBD patients converted (12 to Parkinson's disease (PD), 6 to dementia with Lewy bodies (DLB)) during follow-up...
March 14, 2024: Sleep
#28
JOURNAL ARTICLE
Qi Rui See, Kausar Raheel, Iain Duncan, Nazanin Biabani, Irene Di Giulio, Andrea Romigi, Veena Kumari, David O'Regan, Scott Cairney, Daniele Urso, K Ray Chaudhuri, Valentina Gnoni, Panagis Drakatos, Ivana Rosenzweig
BACKGROUND: Speech graph analysis (SGA) of dreams has recently shown promise as an objective and language-invariant diagnostic tool that can aid neuropsychiatric diagnosis. Whilst the notion that dreaming mentations reflect distinct physiologic processes is not new, such studies in patients with sleep disorders remain exceptionally scarce. Here, using SGA and other dream content analyses, we set to investigate structural and thematic differences in morning dream recalls of patients diagnosed with Non-Rapid Eye Movement Parasomnia (NREMP) and Idiopathic REM Sleep Behavior Disorder (iRBD)...
2024: Nature and Science of Sleep
#29
JOURNAL ARTICLE
Cheng Zhou, Jia You, Xiaojun Guan, Tao Guo, Jingjing Wu, Haoting Wu, Chenqing Wu, Jingwen Chen, Jiaqi Wen, Sijia Tan, Xioajie Duanmu, Jianmei Qin, Peiyu Huang, Baorong Zhang, Wei Cheng, Jianfeng Feng, Xiaojun Xu, Linbo Wang, Minming Zhang
BACKGROUND: Whether there is hypothalamic degeneration in Parkinson's disease (PD) and its association with clinical symptoms and pathophysiological changes remains controversial. OBJECTIVES: We aimed to quantify microstructural changes in hypothalamus using a novel deep learning-based tool in patients with PD and those with probable rapid-eye-movement sleep behavior disorder (pRBD). We further assessed whether these microstructural changes associated with clinical symptoms and free thyroxine (FT4) levels...
March 11, 2024: Neurobiology of Disease
#30
JOURNAL ARTICLE
Kristian Staer, Alex Iranzo, Morten Gersel Stokholm, Victor S Hvingelby, Erik Hvid Danielsen, Karen Østergaard, Mónica Serradell, Marit Otto, Kristina B Svendsen, Alicia Garrido, Dolores Vilas, Joan Santamaria, Arne Møller, Carles Gaig, David J Brooks, Per Borghammer, Eduardo Tolosa, Nicola Pavese
BACKGROUND: Using 11 C-(R)-PK11195-PET, we found increased microglia activation in isolated REM sleep behavior disorder (iRBD) patients. Their role remains to be clarified. OBJECTIVES: The objective is to assess relationships between activated microglia and progression of nigrostriatal dysfunction in iRBD. METHODS: Fifteen iRBD patients previously scanned with 11 C-(R)-PK11195 and 18 F-DOPA-PET underwent repeat 18 F-DOPA-PET after 3 years...
March 13, 2024: Movement Disorders: Official Journal of the Movement Disorder Society
#31
JOURNAL ARTICLE
Mondo Yoshizawa, Yoshiyuki Tamura, Asami Yasuda-Ohata, Shinsuke Yoshihara, Hideki Takasaki, Sadayuki Hashioka
The pathogenesis of rapid eye movement (REM) sleep behavior disorder (RBD) is unclear. According to the cortical hypothesis, severe RBD episode (RBDE) occurs when spinal motoneurons are less inhibited and cortical and limbic systems are more active. We made this study to prove the hypothesis for the development of RBDE using video-polysomnography (VPSG). VPSG records of 35 patients with RBD were analyzed. According to severity, RBDEs were classified into three motor events (MEs): ME 1; small movements or jerks, ME 2; proximal movements including violent behavior, and ME 3; axial movements including bed falls...
October 2023: Sleep and Biological Rhythms
#32
JOURNAL ARTICLE
Christopher Höhn, Michael A Hahn, Janna D Lendner, Kerstin Hoedlmoser
Non-oscillatory measures of brain activity such as the spectral slope and Lempel-Ziv complexity are affected by many neurological disorders and modulated by sleep. A multitude of frequency ranges, particularly a broadband (encompassing the full spectrum) and narrowband approach, have been used especially for estimating the spectral slope. However, the effects of choosing different frequency ranges have not yet been explored in detail. Here, we evaluated the impact of sleep stage and task-engagement (resting, attention and memory) on slope and complexity in a narrow- (30 - 45Hz) and broadband (1 - 45Hz) frequency range in 28 healthy male human subjects (21...
March 12, 2024: ENeuro
#33
JOURNAL ARTICLE
Cristina Simonet, Laura Pérez-Carbonell, Miquel A Galmés-Ordinas, Brook F R Huxford, Harneek Chohan, Aneet Gill, Guy Leschziner, Andrew J Lees, Anette Schrag, Alastair J Noyce
BACKGROUND: Isolated Rapid Eye Movement (REM) sleep Behavior Disorder (iRBD) requires quantitative tools to detect incipient Parkinson's disease (PD). METHODS: A motor battery was designed and compared with the Movement Disorder Society-Unified Parkinson's Disease Rating Scale part III (MDS-UPDRS-III) in people with iRBD and controls. This included two keyboard-based tests (BRadykinesia Akinesia INcoordination tap test and Distal Finger Tapping) and two dual tasking tests (walking and finger tapping)...
March 12, 2024: Movement Disorders: Official Journal of the Movement Disorder Society
#34
JOURNAL ARTICLE
D A Lee, H J Lee, K M Park
This study aimed to investigate the alterations in limbic structure volumes and limbic covariance network in patients with isolated rapid eye movement (REM) sleep behavior disorder (iRBD) and to compare them with healthy controls. We retrospectively enrolled 35 patients with iRBD and 35 healthy controls who underwent three-dimensional T1-weighted brain MRI. Volumetric analysis of subcortical limbic structures, including the hippocampus, amygdala, thalamus, mammillary body, hypothalamus, basal forebrain, septal nuclei, fornix, and nucleus accumbens, was performed...
April 2023: Sleep and Biological Rhythms
#35
JOURNAL ARTICLE
Jarod Rutledge, Benoit Lehallier, Pardis Zarifkar, Patricia Moran Losada, Marian Shahid-Besanti, Dan Western, Priyanka Gorijala, Sephira Ryman, Maya Yutsis, Gayle K Deutsch, Elizabeth Mormino, Alexandra Trelle, Anthony D Wagner, Geoffrey A Kerchner, Lu Tian, Carlos Cruchaga, Victor W Henderson, Thomas J Montine, Per Borghammer, Tony Wyss-Coray, Kathleen L Poston
Parkinson's disease (PD) starts at the molecular and cellular level long before motor symptoms appear, yet there are no early-stage molecular biomarkers for diagnosis, prognosis prediction, or monitoring therapeutic response. This lack of biomarkers greatly impedes patient care and translational research-L-DOPA remains the standard of care more than 50 years after its introduction. Here, we performed a large-scale, multi-tissue, and multi-platform proteomics study to identify new biomarkers for early diagnosis and disease monitoring in PD...
March 11, 2024: Acta Neuropathologica
#36
JOURNAL ARTICLE
Dario Arnaldi, Pietro Mattioli, Stefano Raffa, Matteo Pardini, Federico Massa, Alex Iranzo, Andres Perissinotti, Aida Niñerola-Baizán, Carles Gaig, Monica Serradell, Amaia Muñoz-Lopetegi, Gerard Mayà, Claudio Liguori, Mariana Fernandes, Fabio Placidi, Agostino Chiaravalloti, Karel Šonka, Petr Dušek, David Zogala, Jiri Trnka, Bradley F Boeve, Toji Miyagawa, Val J Lowe, Tomoyuki Miyamoto, Masayuki Miyamoto, Monica Puligheddu, Michela Figorilli, Alessandra Serra, Michele T Hu, Johannes C Klein, Frederik Bes, Dieter Kunz, Valérie Cochen De Cock, Delphine de Verbizier, Giuseppe Plazzi, Elena Antelmi, Michele Terzaghi, Irene Bossert, Kristína Kulcsárová, Alessio Martino, Alessandro Giuliani, Marco Pagani, Flavio Nobili, Silvia Morbelli
OBJECTIVE: To apply a machine learning analysis to clinical and presynaptic dopaminergic imaging data of patients with rapid eye movement (REM) sleep behavior disorder (RBD) to predict the development of Parkinson disease (PD) and dementia with Lewy bodies (DLB). METHODS: In this multicenter study of the International RBD study group, 173 patients (mean age 70.5 ± 6.3 years, 70.5% males) with polysomnography-confirmed RBD who eventually phenoconverted to overt alpha-synucleinopathy (RBD due to synucleinopathy) were enrolled, and underwent baseline presynaptic dopaminergic imaging and clinical assessment, including motor, cognitive, olfaction, and constipation evaluation...
March 11, 2024: Annals of Neurology
#37
JOURNAL ARTICLE
Toshinori Nakamura, Yusuke Arai, Tetsuya Hagiwara, Ryosuke Kitoh, Daimei Sasayama, Shinsuke Washizuka
Lemborexant, an orexin receptor antagonist, is effective not only for sleep disorders but also for preventing and treating delirium. To date, no complex sleep-related behaviors due to lemborexant have been reported. Herein, we present the case of a 69-year-old male patient who was hospitalized for oral floor and tongue cancer and developed delirium after surgery; however, upon lemborexant dosage increase, used to treat insomnia, he developed abnormal nocturnal behavior. This symptom rapidly improved when lemborexant was discontinued...
March 11, 2024: International Clinical Psychopharmacology
#38
JOURNAL ARTICLE
Jèssica Pardo, Victor Montal, Anna Campabadal, Javier Oltra, Carme Uribe, Ignacio Roura, Núria Bargalló, Maria J Martí, Yaroslau Compta, Alex Iranzo, Juan Fortea, Carme Junqué, Bàrbara Segura
BACKGROUND: Evidence regarding cortical atrophy patterns in Parkinson's disease (PD) with probable rapid eye movement sleep behavior disorder (RBD) (PD-pRBD) remains scarce. Cortical mean diffusivity (cMD), as a novel imaging biomarker highly sensitive to detecting cortical microstructural changes in different neurodegenerative diseases, has not been investigated in PD-pRBD yet. OBJECTIVES: The aim was to investigate cMD as a sensitive measure to identify subtle cortical microstructural changes in PD-pRBD and its relationship with cortical thickness (CTh)...
March 8, 2024: Movement Disorders: Official Journal of the Movement Disorder Society
#39
REVIEW
Oliver Leopold Steiner, Jan de Zeeuw
BACKGROUND: Neurodegenerative diseases share retinal abnormalities. Chromatic pupillometry allows in vivo assessment of photoreceptor functional integrity, including melanopsin-expressing retinal ganglion cells. This exploratory meta-analysis assesses retinal photoreceptor functionality in Alzheimer's vs. Parkinson's disease and conducts an in-depth review of applied pupillometric protocols. METHODS: Literature reviews on PubMed and Scopus from 1991 to August 2023 identified chromatic pupillometry studies on Alzheimer's disease (AD; n = 42 patients from 2 studies) and Parkinson's disease (PD; n = 66 from 3 studies)...
February 27, 2024: Parkinsonism & related Disorders
#40
JOURNAL ARTICLE
Niels Okkels, Michel J Grothe, John-Paul Taylor, Steen Gregers Hasselbalch, Tatyana D Fedorova, Karoline Knudsen, Sygrid van der Zee, Teus van Laar, Nicolaas Bohnen, Per Borghammer, Jacob Horsager
Cholinergic degeneration is significant in Lewy body disease, including Parkinson's disease, dementia with Lewy bodies, and isolated REM sleep behavior disorder. Extensive research has demonstrated cholinergic alterations in the central nervous system of these disorders. More recently, studies have revealed cholinergic denervation in organs that receive parasympathetic denervation. This enables a comprehensive review of cholinergic changes in Lewy body disease, encompassing both central and peripheral regions, various disease stages, and diagnostic categories...
March 4, 2024: Brain
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