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REM sleep behavior disorder

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https://www.readbyqxmd.com/read/29029348/dysregulation-of-sleep-behavioral-states-in-narcolepsy
#1
Sarah F Schoch, Esther Werth, Rositsa Poryazova, Thomas E Scammell, Christian R Baumann, Lukas L Imbach
Study Objectives: Patients with narcolepsy suffer from poor maintenance of wakefulness and fragmented night sleep, but the underlying mechanism of sleep boundary dysregulation remains little understood. The goal of this study was to quantify abnormal sleep-wake regulation in narcolepsy patients. Methods: Using a model-based approach (state space analysis), we analyzed overnight EEG recordings in ten patients with narcolepsy type 1 and age- and gender-matched healthy control subjects...
October 5, 2017: Sleep
https://www.readbyqxmd.com/read/29029239/what-does-the-sleeping-brain-say-syntax-and-semantics-of-sleep-talking-in-healthy-subjects-and-in-parasomnia-patients
#2
Isabelle Arnulf, Ginevra Uguccioni, Frederick Gay, Etienne Baldayrou, Jean-Louis Golmard, Frederique Gayraud, Alain Devevey
Objectives: Speech is a complex function in humans, but the linguistic characteristics of sleep talking are unknown. We analyzed sleep-associated speech in adults, mostly (92%) during parasomnias. Methods: The utterances recorded during night-time video-polysomnography were analyzed for number of words, propositions and speech episodes, frequency, gaps and pauses (denoting turn-taking in the conversation), lemmatization, verbosity, negative/imperative/interrogative tone, first/second person, politeness and abuse...
October 5, 2017: Sleep
https://www.readbyqxmd.com/read/28990131/diagnosis-and-management-of-cognitive-and-behavioral-changes-in-dementia-with-lewy-bodies
#3
REVIEW
Babak Tousi
Proper diagnosis of dementia with Lewy bodies (DLB) in clinical practice remains suboptimal as many cases are misdiagnosed, usually as Alzheimer disease (AD) or Parkinson's disease (PD) and, in rare cases, psychosis. Therefore, it is important for patients with dementia to be thoroughly evaluated by a specialist who is familiar with current diagnostic tests and treatment options. New diagnostic criteria from the Dementia with Lewy Bodies Consortium have been developed to increase diagnostic sensitivity for DLB (Diagnosis and management of dementia with Lewy bodies: fourth consensus report of the DLB Consortium; McKeith et al...
October 9, 2017: Current Treatment Options in Neurology
https://www.readbyqxmd.com/read/28988683/smoking-and-age-at-onset-of-both-motor-and-non-motor-symptoms-in-parkinson-s-disease
#4
Angelo Fabio Gigante, Tommaso Martino, Giovanni Iliceto, Giovanni Defazio
INTRODUCTION: Several evidence suggest that smoking may decrease the risk of Parkinson's disease and is associated with an older age-at-onset of motor signs. The relation between smoking and age-at-onset of non-motor symptoms has never been analyzed. Objective of the study is to evaluate whether smoking habit and pack-years of smoking are associated with a delay of age-at-onset of motor signs, and of some non-motor symptoms. METHODS: The study population consisted of 262 consecutive parkinsonian patients...
September 29, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/28979204/hyposmia-is-associated-with-rbd-for-pd-patients-with-variants-of-snca
#5
Yuanyuan Li, Wenyan Kang, Linyuan Zhang, Liche Zhou, Mengyue Niu, Jun Liu
Objective: Hyposmia may occur simultaneously with REM sleep behavior disorder (RBD) as a specific phenotype in Parkinson's Diseases (PD), of which the disease progression is fast. In the study, we tried to identify whether the genotypic characteristics could participate in the co-occurrence of hyposmia and RBD in PD patients. Methods: 152 PD patients were recruited from the Department of Neurology, Ruijin Hospital affiliated to Shanghai JiaoTong University School of Medicine from 2011 to 2016, with comprehensive clinical assessment performing...
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/28959190/cellular-and-molecular-mechanisms-of-rem-sleep-homeostatic-drive-a-plausible-component-for-behavioral-plasticity
#6
Subimal Datta, Michael D Oliver
Homeostatic regulation of REM sleep drive, as measured by an increase in the number of REM sleep transitions, plays a key role in neuronal and behavioral plasticity (i.e., learning and memory). Deficits in REM sleep homeostatic drive (RSHD) are implicated in the development of many neuropsychiatric disorders. Yet, the cellular and molecular mechanisms underlying this RSHD remain to be incomplete. To further our understanding of this mechanism, the current study was performed on freely moving rats to test a hypothesis that a positive interaction between extracellular-signal-regulated kinase 1 and 2 (ERK1/2) activity and brain-derived neurotrophic factor (BDNF) signaling in the pedunculopontine tegmentum (PPT) is a causal factor for the development of RSHD...
2017: Frontiers in Neural Circuits
https://www.readbyqxmd.com/read/28958075/mri-biomarkers-to-assess-substantia-nigra-damage-in-idiopathic-rem-sleep-behavior-disorder
#7
Nadya Pyatigorskaya, Rahul Gaurav, Dario Arnaldi, Smaranda Leu-Semenescu, Lydia Yahia-Cherif, Romain Valabregue, Marie Vidailhet, Isabelle Arnulf, Stephane Lehéricy
Objectives: Idiopathic rapid eye movement sleep behavior disorder (iRBD) is considered to be a prodromal stage of Parkinson's disease (PD). At PD onset, 40 to 70% of the dopaminergic neurons in the substantia nigra (SN) are already lost. Thus, milder SN damage is expected in iRBD patients. We aimed to quantify SN damage in iRBD patients using multimodal MRI and to determine biomarker efficacy in preclinical Parkinsonism. Methods: Nineteen patients with iRBD and 18 controls underwent 3-Tesla MRI, including diffusion tensor imaging, neuromelanin (NM)-sensitive imaging and T2* mapping...
August 31, 2017: Sleep
https://www.readbyqxmd.com/read/28958035/sleep-wake-physiology-and-quantitative-eeg-analysis-of-the-neuroligin-3-knockout-rat-model-of-autism-spectrum-disorder
#8
Alexia M Thomas, Michael D Schwartz, Michael D Saxe, Thomas S Kilduff
Study Objectives: Neuroligin-3 (NLGN3) is one of many genes associated with autism spectrum disorder (ASD). Sleep dysfunction is highly prevalent in ASD, but has not been rigorously examined in ASD models. Here, we evaluated sleep/wake physiology and behavioral phenotypes of rats with genetic ablation of Nlgn3. Methods: Male Nlgn3 knockout (KO) and wild-type (WT) rats were assessed using a test battery for ASD-related behaviors and also implanted with telemeters to record the electroencephalogram (EEG), electromyogram (EMG), body temperature, and locomotor activity...
August 31, 2017: Sleep
https://www.readbyqxmd.com/read/28958020/caveats-of-neurodegenerative-risk-stratification-in-idiopathic-rem-sleep-behavior-disorder-by-use-of-the-mds-research-for-prodromal-parkinson-s-disease
#9
Philipp Mahlknecht, Alex Iranzo, Ambra Stefani, Monica Serradell, Joan Santamaria, Eduardo Tolosa, Birgit Högl, Werner Poewe
No abstract text is available yet for this article.
August 26, 2017: Sleep
https://www.readbyqxmd.com/read/28958010/noradrenergic-dysfunction-could-contribute-to-cognitive-impairments-in-patients-with-parkinson-s-disease-and-rem-sleep-behavior-disorder
#10
https://www.readbyqxmd.com/read/28923293/two-polysomnographic-features-of-rem-sleep-behavior-disorder-clinical-variations-insight-for-parkinson-s-disease
#11
Yun Shen, Yong-Ping Dai, Yi Wang, Jie Li, Kang-Ping Xiong, Cheng-Jie Mao, Jun-Ying Huang, Wei-Feng Luo, Chun-Feng Liu
INTRODUCTION: Loss of REM sleep muscle atonia (RWA) and dream-enactment behavior (DEB) are two associated features of REM sleep behavior disorder (RBD), which is frequently associated with Parkinson's disease (PD). Few studies have examined both DEB and RWA simultaneously in patients with PD. This study aimed to evaluate relationships between RWA, DEB and clinical characteristics of PD. METHODS: We conducted overnight polysomnography in 145 patients with PD. DEB (motor behaviors and/or vocalizations during REM) and increased RWA (IRWA; tonic and phasic chin EMG density ≥ 30% and ≥15%, respectively) were identified...
September 5, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/28900980/-wild-dreams-and-injured-bed-partners-the-rem-sleep-behavior-disorder-as-a-precursor-of-neurodegenerative-disorders
#12
REVIEW
Jan Rémi
No abstract text is available yet for this article.
September 2017: MMW Fortschritte der Medizin
https://www.readbyqxmd.com/read/28892547/non-rapid-eye-movement-arousal-parasomnias-in-children
#13
Vijayabharathi Ekambaram, Kiran Maski
Parasomnia is a common pediatric sleep disorder that can cause parents or caregivers distress when experienced by their children. Based on the International Classification of Sleep Disorders, parasomnias can be divided into two subgroups: non-rapid eye movement (NREM) parasomnias and rapid eye movement (REM) parasomnias. REM sleep parasomnias include nightmares, REM behavior disorder, and sleep paralysis, whereas NREM sleep parasomnias include disorders of arousal such as confusional arousals, sleepwalking, sleep talking, night terrors, and sleep-related eating disorder...
September 1, 2017: Pediatric Annals
https://www.readbyqxmd.com/read/28890381/the-link-between-parkinson-s-disease-and-rapid-eye-movement-sleep-behavior-disorder-with-dream-enactment-possible-implications-for-early-rehabilitation
#14
Brian P Johnson, Kelly P Westlake
The purpose of this paper is twofold. First, to inform readers of the link between the loss of motor inhibition during rapid eye movement (REM) sleep dreaming, diagnosed as REM sleep behavior disorder (RBD), and the future onset of neurodegenerative disorders, such as Parkinson's Disease and dementia with lewy bodies. It has been reported that motor disinhibition during rapid eye movement sleep often precedes onset of these disorders by years or even decades. Second, to consider that identification of RBD and the early involvement of rehabilitation and/or development of home exercise plans may aid in prolonging and even increasing function, independence, and quality of life should such neurodegenerative disorders develop later in life...
September 7, 2017: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/28887374/rem-sleep-behavior-disorder-is-related-to-enteric-neuropathology-in-parkinson-disease
#15
Laurène Leclair-Visonneau, Thomas Clairembault, Emmanuel Coron, Séverine Le Dily, Fabienne Vavasseur, Marie Dalichampt, Yann Péréon, Michel Neunlist, Pascal Derkinderen
OBJECTIVE: To determine whether REM sleep behavior disorder (RBD) in Parkinson disease (PD) is associated with lesions and dysfunctions of the autonomic nervous system by evaluating enteric phosphorylated α-synuclein histopathology (PASH) and permeability. METHODS: A total of 45 patients with PD were included in this cross-sectional study. RBD was diagnosed on the basis of a standardized clinical interview and confirmed by polysomnography. For each patient, 5 biopsies were taken at the junction between the sigmoid and descending colon during the course of a rectosigmoidoscopy...
October 10, 2017: Neurology
https://www.readbyqxmd.com/read/28871332/rem-sleep-behavior-disorder-autonomic-dysfunction-and-synuclein-related-neurodegeneration-where-do-we-stand
#16
REVIEW
Giacomo Chiaro, Giovanna Calandra-Buonaura, Annagrazia Cecere, Francesco Mignani, Luisa Sambati, Giuseppe Loddo, Pietro Cortelli, Federica Provini
INTRODUCTION: From newfound parasomnia to a marker of future synucleinopathy, since its first description in 1986, REM sleep behavior disorder (RBD) has been systematically tackled from virtually many viewpoints in basic, translational, and clinical studies. The time delay between RBD and synucleinopathy onset offers an exceptional window for observation and design of neuroprotective trials. In the last few years, research has focused on characterizing possible differences within RBD patients in order to draw potential profiles more or less susceptible to further neurodegeneration...
September 4, 2017: Clinical Autonomic Research: Official Journal of the Clinical Autonomic Research Society
https://www.readbyqxmd.com/read/28864676/a-predictive-model-to-identify-parkinson-disease-from-administrative-claims-data
#17
Susan Searles Nielsen, Mark N Warden, Alejandra Camacho-Soto, Allison W Willis, Brenton A Wright, Brad A Racette
OBJECTIVE: To use administrative medical claims data to identify patients with incident Parkinson disease (PD) prior to diagnosis. METHODS: Using a population-based case-control study of incident PD in 2009 among Medicare beneficiaries aged 66-90 years (89,790 cases, 118,095 controls) and the elastic net algorithm, we developed a cross-validated model for predicting PD using only demographic data and 2004-2009 Medicare claims data. We then compared this model to more basic models containing only demographic data and diagnosis codes for constipation, taste/smell disturbance, and REM sleep behavior disorder, using each model's receiver operator characteristic area under the curve (AUC)...
October 3, 2017: Neurology
https://www.readbyqxmd.com/read/28856094/alterations-in-striato-thalamo-pallidal-intrinsic-functional-connectivity-as-a-prodrome-of-parkinson-s-disease
#18
Eran Dayan, Nina Browner
Although the diagnosis of Parkinson's disease (PD) remains anchored around the cardinal motor symptoms of bradykinesia, rest tremor, rigidity and postural instability, it is becoming increasingly clear that the clinical phase of the disease is preceded by a long period of neurodegeneration, which is not readily evident in terms of motor dysfunction. The neurobiological mechanisms that underpin this prodromal phase of PD remain poorly understood. Based on converging evidence of basal ganglia (BG) dysfunction in early PD, we set out to establish whether the prodromal phase of the disease is characterized by alterations in functional communication within the input and output structures of the BG...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28837993/clinical-overview-of-rem-sleep-behavior-disorder
#19
Verna R Porter, Alon Y Avidan
No abstract text is available yet for this article.
August 2017: Seminars in Neurology
https://www.readbyqxmd.com/read/28833467/dopamine-transporter-imaging-deficit-predicts-early-transition-to-synucleinopathy-in-idiopathic-rapid-eye-movement-sleep-behavior-disorder
#20
Alex Iranzo, Joan Santamaría, Francesc Valldeoriola, Monica Serradell, Manel Salamero, Carles Gaig, Aida Niñerola-Baizán, Raquel Sánchez-Valle, Albert Lladó, Roberto De Marzi, Ambra Stefani, Klaus Seppi, Javier Pavia, Birgit Högl, Werner Poewe, Eduard Tolosa, Francisco Lomeña
OBJECTIVE: To determine the usefulness of dopamine transporter (DAT) imaging to identify idiopathic rapid eye movement sleep behavior disorder (IRBD) patients at risk for short-term development of clinically defined synucleinopathy. METHODS: Eighty-seven patients with polysomnography-confirmed IRBD underwent (123) I-FP-CIT DAT-SPECT. Results were compared to 20 matched controls without RBD who underwent DAT-SPECT. In patients, FP-CIT uptake was considered abnormal when values were two standard deviations below controls' mean uptake...
September 2017: Annals of Neurology
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