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REM sleep behavior disorder

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https://www.readbyqxmd.com/read/29456351/quality-of-sleep-and-sleep-disorders-in-patients-with-parkinsonism-a-polysomnography-based-study-from-rural-south-india
#1
Dushyanth Babu Jasti, Sarat Mallipeddi, A Apparao, B Vengamma, Satyarao Kolli, A Mohan
Objective: The objective of this study is to study the quality of sleep, sleep disorders, and polysomnographic profile in Parkinsonism patients from rural areas and to correlate polysomnographic profile with the staging of disease and with sleep questionnaire. Materials and Methods: Between May 2014 and December 2015, 168 Parkinsonism patients were prospectively screened using sleep questionnaire; Epworth Sleepiness Scale (ESS), Pittsburgh Sleep Quality Index (PSQI), Parkinson Disease Sleep Score-2 (PDSS-2)...
January 2018: Journal of Neurosciences in Rural Practice
https://www.readbyqxmd.com/read/29449121/sleep-disorders-and-parkinson-disease-lessons-from-genetics
#2
REVIEW
Ziv Gan-Or, Roy N Alcalay, Guy A Rouleau, Ronald B Postuma
Parkinson disease is a common, age-related neurodegenerative disorder, projected to afflict millions of individuals in the near future. Understanding its etiology and identifying clinical, genetic or biological markers for Parkinson disease onset and progression is therefore of major importance. Various sleep-related disorders are the most common group of non-motor symptoms in advanced Parkinson disease, but they can also occur during its prodromal phase. However, with the exception of REM sleep behavior disorder, it is unclear whether they are part of the early pathological process of Parkinson disease, or if they develop as Parkinson disease advances because of treatments and neurodegeneration progression...
January 31, 2018: Sleep Medicine Reviews
https://www.readbyqxmd.com/read/29442234/microstructural-changes-in-patients-with-parkinson-disease-and-rem-sleep-behavior-disorder-depressive-symptoms-versus-non-depressed
#3
Farzaneh Ghazi Sherbaf, Farzaneh Rahmani, Sommayeh Mohammadi Jooyandeh, Mohammad Hadi Aarabi
Search for Parkinson's disease (PD) progression biomarkers has led to the identification of both motor and non-motor symptoms relevant of prodromal PD that could be eye-opening to the spreading underlying Lewy body pathogenesis. One most robust predictor of PD is the REM sleep behavior disorder (RBD), and one most common early non-motor symptom of PD is depression. With RBD, frequently coexisting with clinical depression and both predicting dopamine transmission dysfunction, we aimed to survey structural associates of depressive symptoms in early PD patients with comorbid RBD...
February 13, 2018: Acta Neurologica Belgica
https://www.readbyqxmd.com/read/29429645/daytime-sleepiness-in-dementia-with-lewy-bodies-is-associated-with-neuronal-depletion-of-the-nucleus-basalis-of-meynert
#4
Koji Kasanuki, Tanis J Ferman, Melissa E Murray, Michael G Heckman, Otto Pedraza, Fadi S Hanna Al-Shaikh, Takayasu Mishima, Nancy N Diehl, Jay A van Gerpen, Ryan J Uitti, Zbigniew K Wszolek, Neill R Graff-Radford, Dennis W Dickson
INTRODUCTION: Excessive daytime sleepiness is a commonly reported clinical feature of dementia with Lewy bodies (DLB) that can occur early in the disease. Cholinergic depletion is known to be severe in DLB, even when dementia severity is mild. The nucleus basalis of Meynert serves as a primary source of cortical acetylcholine, and has a role in facilitating cortical activation and arousal. We sought to determine whether daytime sleepiness at the initial evaluation of patients with DLB was associated with neuronal loss in the nucleus basalis of Meynert...
February 3, 2018: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29412983/parasomnias-and-sleep-related-movement-disorders-in-older-adults
#5
REVIEW
Alex Iranzo
Parasomnias and sleep-related movement disorders are important problems in older adults. Sleep paralysis is rare, but may occur in families. In a minority of patients with disorders of arousal, the episodes persist until the age of 70. Zolpidem and other medications may induce sleepwalking and sleep-related eating. Most patients with idiopathic rapid eye movement (REM) sleep behavior disorder eventually develop Parkinson's disease or dementia with Lewy bodies. Anti-IgLON5 disease includes abnormal behaviors in NREM and REM sleep...
March 2018: Sleep Medicine Clinics
https://www.readbyqxmd.com/read/29411691/prospective-memory-in-idiopathic-rem-sleep-behavior-disorder-with-or-without-mild-cognitive-impairment-a-preliminary-study
#6
Sonia Marcone, Jean-François Gagnon, Catherine Desjardins, Annie-Claude David, Ronald B Postuma, Jacques Montplaisir, Sven Joubert, Isabelle Rouleau
OBJECTIVE: The ability to execute delayed intentions, known as prospective memory (PM), is crucial to everyday living. PM failures are reported in mild cognitive impairment (MCI) and Parkinson's disease, however, no study to date has investigated PM functioning in individuals at high risk of developing these conditions, precisely those diagnosed with idiopathic REM sleep behavior disorder (iRBD). We aimed to assess PM in iRBD according to patients' cognitive status and to determine the underlying nature of their difficulties...
February 7, 2018: Clinical Neuropsychologist
https://www.readbyqxmd.com/read/29402935/ventromedial-medulla-inhibitory-neuron-inactivation-induces-rem-sleep-without-atonia-and-rem-sleep-behavior-disorder
#7
Sara Valencia Garcia, Frédéric Brischoux, Olivier Clément, Paul-Antoine Libourel, Sébastien Arthaud, Michael Lazarus, Pierre-Hervé Luppi, Patrice Fort
Despite decades of research, there is a persistent debate regarding the localization of GABA/glycine neurons responsible for hyperpolarizing somatic motoneurons during paradoxical (or REM) sleep (PS), resulting in the loss of muscle tone during this sleep state. Combining complementary neuroanatomical approaches in rats, we first show that these inhibitory neurons are localized within the ventromedial medulla (vmM) rather than within the spinal cord. We then demonstrate their functional role in PS expression through local injections of adeno-associated virus carrying specific short-hairpin RNA in order to chronically impair inhibitory neurotransmission from vmM...
February 5, 2018: Nature Communications
https://www.readbyqxmd.com/read/29390088/insights-into-polysomnography-confirmed-rem-sleep-behavior-disorder-from-new-prevalence-and-gender-data-in-the-general-population
#8
Carlos H Schenck, Mark W Mahowald
No abstract text is available yet for this article.
January 30, 2018: Sleep
https://www.readbyqxmd.com/read/29386491/-a-case-of-severe-obstructive-sleep-apnea-mimicking-rem-sleep-behavior-disorder
#9
Yoko Fujii, Mutsumi Okura, Hidekazu Uemori, Mitsutaka Taniguchi, Motoharu Ohi
The rapid eye movement (REM) sleep behavior disorder (RBD) is a parasomnia characterized by dream-enacting behaviors related to the loss of the normal generalized skeletal muscle atonia during REM sleep, and shows REM sleep without atonia (RWA) during polysomnography (PSG). Patients with idiopathic RBD have been known to have a siginificantly increased risk of developing one of the α-synucleiopathies later in life, therefore the diagnosis of RBD is very important and must be dealt with carefully. A 51-year-old man was identified presenting dream-enacting behaviors and unpleasant dreams suggesting the diagnosis of RBD, in addition to snoring and excessive daytime sleepiness...
January 31, 2018: Rinshō Shinkeigaku, Clinical Neurology
https://www.readbyqxmd.com/read/29386443/-electromyography-analysis-of-rapid-eye-movement-sleep-behavior-disorder
#10
Natsuko Nakano, Fumiya Kinoshita, Hiroki Takada, Meiho Nakayama
Polysomnography (PSG), which records physiological phenomena including brain waves, breathing status, and muscle tonus, is useful for the diagnosis of sleep disorders as a gold standard. However, measurement and analysis are complex for several specific sleep disorders, such as rapid eye movement (REM) sleep behavior disorder (RBD). Usually, brain waves during REM sleep indicate an awakening pattern under relaxed conditions of skeletal and antigravity muscles. However, these muscles are activated during REM sleep when patients suffer from RBD...
2018: Nihon Eiseigaku Zasshi. Japanese Journal of Hygiene
https://www.readbyqxmd.com/read/29360192/diagnostic-criteria-for-disorders-of-arousal-a-video-polysomnography-assessment
#11
Régis Lopez, Yun Shen, Sofiene Chenini, Anna Laura Rassu, Elisa Evangelista, Lucie Barateau, Isabelle Jaussent, Yves Dauvilliers
STUDY OBJECTIVES: To assess video-polysomnographic (vPSG) criteria and their cut-off values for the diagnosis of disorders of arousal (DOA; sleepwalking, sleep terror). METHODS: One hundred and sixty adult patients with DOA and 50 sex- and age-matched healthy participants underwent a clinical evaluation and vPSG assessment to quantify slow wave sleep (SWS) interruptions (SWS fragmentation index; slow/mixed and fast arousal ratios and indexes per hour) and the associated behaviors...
January 23, 2018: Annals of Neurology
https://www.readbyqxmd.com/read/29353182/observations-on-muscle-activity-in-rem-sleep-behavior-disorder-assessed-with-a-semi-automated-scoring-algorithm
#12
Jesper Jeppesen, Marit Otto, Yoon Frederiksen, Allan K Hansen, Tatyana D Fedorova, Karoline Knudsen, Adjmal Nahimi, David J Brooks, Per Borghammer, Michael Sommerauer
OBJECTIVES: Rapid eye movement (REM) sleep behavior disorder (RBD) is defined by dream enactment due to a failure of normal muscle atonia. Visual assessment of this muscle activity is time consuming and rater-dependent. METHODS: An EMG computer algorithm for scoring 'tonic', 'phasic' and 'any' submental muscle activity during REM sleep was evaluated compared with human visual ratings. Subsequently, 52 subjects were analyzed with the algorithm. Duration and maximal amplitude of muscle activity, and self-awareness of RBD symptoms were assessed...
December 28, 2017: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/29351827/nocturnal-rem-sleep-without-atonia-is-a-diagnostic-biomarker-of-pediatric-narcolepsy
#13
Saadoun Bin-Hasan, Aleksandar Videnovic, Kiran Maski
STUDY OBJECTIVES: Compare nocturnal REM sleep without atonia (nRWA) and REM sleep behavior disorder (RBD) between pediatric patients with and without narcolepsy and determine if the nRWA index is a valid diagnostic biomarker for narcolepsy. METHODS: Retrospective cohort study of children ages 6 to 18 years who completed a nocturnal polysomnogram (PSG) and Multiple Sleep Latency Test (MSLT). Our study sample included 11 patients with narcolepsy type 1 (NT1), 6 with narcolepsy type 2 (NT2), 12 with idiopathic hypersomnia (IH), and 11 with subjective hypersomnia (sHS)...
February 15, 2018: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
https://www.readbyqxmd.com/read/29351000/age-effects-on-cerebral-oxygenation-and-behavior-in-children-with-sleep-disordered-breathing
#14
Knarik Tamanyan, Lisa M Walter, Aidan Weichard, Margot J Davey, Gillian M Nixon, Sarah N Biggs, Rosemary Sc Horne
RATIONALE: Childhood sleep disordered breathing ranges in severity from primary snoring to obstructive sleep apnea and is associated with behavioral and neurocognitive deficits. It remains unknown why children with primary snoring, who do not experience peripheral oxygen desaturation or sleep fragmentation, experience similar daytime deficits as those with obstructive sleep apnea or why effects are age dependent. OBJECTIVE: To examine cerebral tissue oxygenation and oxygen extraction as an explanation for daytime deficits in children with primary snoring...
January 19, 2018: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29326058/sleep-architecture-is-altered-in-the-reserpine-induced-fibromyalgia-model-in-ovariectomized-rats
#15
Alberto Hernandez-Leon, Alonso Fernández-Guasti, Adrián Martínez, Francisco Pellicer, María Eva González-Trujano
Fibromyalgia (FM) is a musculoskeletal chronic pain syndrome with various concomitant symptoms like sleep disorders. FM patients are mainly women and menopause might play an important role in the altered processing of somatosensory information. Adverse effects and moderated efficacy of drugs promote treatment discontinuation by patients. Animal models of FM report pain and depression-like behaviors, but none of them have explored sleep disturbance as possible marker in the preclinic diagnostic. The aim of this study was to investigate alterations of the sleep architecture in the reserpine (RES)-induced FM model in ovarectomized (OVX) rats...
January 8, 2018: Behavioural Brain Research
https://www.readbyqxmd.com/read/29313153/first-symptoms-in-multiple-system-atrophy
#16
Jake H McKay, William P Cheshire
PURPOSE: The initial symptoms of multiple system atrophy (MSA) and, in particular, early autonomic symptoms, have received less attention than motor symptoms. Whereas pathognomonic motor signs are essential to diagnostic specificity, early symptoms important to recognition of a neurodegenerative disorder may be less apparent or diagnostically ambiguous. This observational study sought to identify the very earliest symptoms in the natural history of MSA. METHODS: Detailed clinical histories focusing on early symptoms were obtained from 30 subjects recently diagnosed with MSA...
January 8, 2018: Clinical Autonomic Research: Official Journal of the Clinical Autonomic Research Society
https://www.readbyqxmd.com/read/29234278/effects-of-social-defeat-stress-on-sleep-in-mice
#17
Fiona Henderson, Vincent Vialou, Salah El Mestikawy, Véronique Fabre
Stress plays a key role in the development of psychiatric disorders and has a negative impact on sleep integrity. In mice, chronic social defeat stress (CSDS) is an ethologically valid model of stress-related disorders but little is known about its effects on sleep regulation. Here, we investigated the immediate and long-term effects of 10 consecutive days of social defeat (SD) on vigilance states in C57Bl/6J male mice. Social behavior was assessed to identify susceptible mice, i.e., mice that develop long-lasting social avoidance, and unsusceptible mice...
2017: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/29232183/loss-of-substantia-nigra-hyperintensity-at-3-0-t-mr-imaging-in-idiopathic-rem-sleep-behavior-disorder-comparison-with-123i-fp-cit-spect
#18
Yun Jung Bae, Jong-Min Kim, Kyeong Joon Kim, Eunhee Kim, Hyun Soo Park, Seo Young Kang, In-Young Yoon, Jee-Young Lee, Beomseok Jeon, Sang Eun Kim
Purpose To examine whether the loss of nigral hyperintensity (NH) on 3.0-T susceptibility-weighted (SW) magnetic resonance (MR) images can help identify high synucleinopathy risk in patients with idiopathic rapid eye movement sleep behavior disorder (iRBD). Materials and Methods Between March 2014 and April 2015, 18 consecutively recruited patients with iRBD were evaluated with 3.0-T SW imaging and iodine 123-2β-carbomethoxy-3β-(4-iodophenyl)-N-(3-fluoropropyl)-nortropane (123I-FP-CIT) single photon emission computed tomography and compared with 18 healthy subjects and 18 patients with Parkinson disease (PD)...
December 12, 2017: Radiology
https://www.readbyqxmd.com/read/29216391/prevalence-and-determinants-of-rem-sleep-behavior-disorder-in-the-general-population
#19
José Haba-Rubio, Birgit Frauscher, Pedro Marques-Vidal, Jérôme Toriel, Nadia Tobback, Daniela Andries, Martin Preisig, Peter Vollenweider, Ronald Postuma, Raphaël Heinzer
Study Objectives: REM sleep behavior disorder (RBD) is a parasomnia associated with neurodegenerative synucleinopathies. Its prevalence is largely unknown. This study determined the prevalence and characteristics of RBD in the general population using gold-standard polysomnography. Methods: Full polysomnographic data from 1997 subjects (age=59±11.1 years, 53.6% women) participating in a population-based study (HypnoLaus, Lausanne, Switzerland) were collected. Sleep-related complaints and habits were investigated using various sleep measures including the Munich Parasomnia Screening (MUPS) questionnaire, which includes two questions evaluating complex motor behaviors suggestive of RBD...
December 5, 2017: Sleep
https://www.readbyqxmd.com/read/29170000/sleep-disorder-and-altered-locomotor-activity-as-biomarkers-of-the-parkinson-s-disease-cholinopathy-in-rat
#20
Jelena Ciric, Katarina Lazic, Slobodan Kapor, Milka Perovic, Jelena Petrovic, Vesna Pesic, Selma Kanazir, Jasna Saponjic
In order to find out the possible earliest biomarkers of Parkinson's disease (PD) cholinopathy, we followed the impact of bilateral pedunculopontine tegmental nucleus (PPT) lesion in rat on: the cortical and hippocampal sleep/wake states architectures, all sleep states related EEG microstructures, sleep spindles, the basal and stimulated locomotor activity. Sleep and basal locomotor activity in adult Wistar rats were followed during their inactive circadian phase, and throughout the same aging period. The bilateral PPT lesions were done by 0...
February 26, 2018: Behavioural Brain Research
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