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MPO and cardiovascular disease

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https://www.readbyqxmd.com/read/29673593/augmented-neutrophil-extracellular-traps-formation-promotes-atherosclerosis-development-in-socially-defeated-apoe-mice
#1
Keita Yamamoto, Hiroyuki Yamada, Noriyuki Wakana, Masakazu Kikai, Kensuke Terada, Naotoshi Wada, Shinichiro Motoyama, Makoto Saburi, Takeshi Sugimoto, Daisuke Kami, Takehiro Ogata, Masakazu Ibi, Chihiro Yabe-Nishimura, Satoaki Matoba
Depression is an independent risk factor of cardiovascular disease (CVD); however, the causal association remains undefined. We exposed mice to repeated social defeat (RSD) to precipitate depressive-like behaviors, and investigated the effects on atherosclerosis. Eight-week-old male apoE-/- mice were exposed to RSD by housing with a larger CD-1 mouse in a shared home cage. They were subjected to vigorous physical contact daily for 10 consecutive days and fed a high-cholesterol diet (HCD) for 6 weeks. The social interaction ratio and immobility time showed dramatic social avoidance before and after HCD feeding...
April 16, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29669993/myeloperoxidase-as-an-active-disease-biomarker-recent-biochemical-and-pathological-perspectives
#2
REVIEW
Amjad A Khan, Mohammed A Alsahli, Arshad H Rahmani
Myeloperoxidase (MPO) belongs to the family of heme-containing peroxidases, produced mostly from polymorphonuclear neutrophils. The active enzyme (150 kDa) is the product of the MPO gene located on long arm of chromosome 17. The primary gene product undergoes several modifications, such as the removal of introns and signal peptides, and leads to the formation of enzymatically inactive glycosylated apoproMPO which complexes with chaperons, producing inactive proMPO by the insertion of a heme moiety. The active enzyme is a homodimer of heavy and light chain protomers...
April 18, 2018: Medical Sciences: Open Access Journal
https://www.readbyqxmd.com/read/29614255/the-other-myeloperoxidase-emerging-functions
#3
REVIEW
Luc Vanhamme, Karim Zouaoui Boudjeltia, Pierre Van Antwerpen, Cédric Delporte
Myeloperoxidase (MPO) is a member of the mammalian peroxidase family. It is mainly expressed in neutrophils, monocytes and macrophages. As a catalyzer of reactive oxidative species and radical species formation, it contributes to neutrophil bactericidal activity. Nevertheless MPO invalidation does not seem to have major health consequences in affected individuals. This suggests that MPO might have alternative functions supporting its conservation during evolution. We will review the available data supporting these non-canonical functions in terms of tissue specific expression, function and enzymatic activity...
March 31, 2018: Archives of Biochemistry and Biophysics
https://www.readbyqxmd.com/read/29590135/a-myeloperoxidase-precursor-pro-myeloperoxidase-is-present-in-human-plasma-and-elevated-in-cardiovascular-disease-patients
#4
Irada S Khalilova, Nina Dickerhof, Tessa J Mocatta, Catriona J Bhagra, Dougal R McClean, Christian Obinger, Anthony J Kettle
Myeloperoxidase (MPO)-derived oxidants have emerged as a key contributor to tissue damage in inflammatory conditions such as cardiovascular disease. Pro-myeloperoxidase (pro-MPO), an enzymatically active precursor of myeloperoxidase (MPO), is known to be secreted from cultured bone marrow and promyelocytic leukemia cells, but evidence for the presence of pro-MPO in circulation is lacking. In the present study, we used a LC-MS/MS in addition to immunoblot analyses to show that pro-MPO is present in human blood plasma...
2018: PloS One
https://www.readbyqxmd.com/read/29581235/myeloperoxidase-derived-oxidants-damage-artery-wall-proteins-in-an-animal-model-of-chronic-kidney-disease-accelerated-atherosclerosis
#5
Lixia Zeng, Anna V Mathew, Jaeman Byun, Kevin B Atkins, Frank C Brosius, Subramaniam Pennathur
Increased myeloperoxidase (MPO) levels and activity are associated with increased cardiovascular risk among individuals with chronic kidney disease (CKD). However, a lack of good animal models for examining the presence and catalytic activity of MPO in vascular lesions has impeded mechanistic studies into CKD-associated cardiovascular diseases. Here, we show for the first time that exaggerated atherosclerosis in a pathophysiologically relevant CKD mouse model is associated with increased macrophage-derived MPO activity...
March 26, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29571590/cardiovascular-risk-biomarkers-and-metabolically-unhealthy-status-in-prepubertal-children-comparison-of-definitions
#6
A I Rupérez, J Olza, M Gil-Campos, R Leis, G Bueno, C M Aguilera, A Gil, L A Moreno
BACKGROUND AND AIMS: The early onset of cardio-metabolic abnormalities, known as metabolically unhealthy (MU) status, is highly associated with obesity and cardiovascular disease (CVD), as well as with increased morbidity and mortality later in life. Given the lack of a consensus MU classification for prepubertal children, we aimed to compare available MU definitions in terms of their association with CVD risk biomarkers. METHODS AND RESULTS: A total of 930 prepubertal children (622 with overweight/obesity, 462 males) aged 5-10...
February 16, 2018: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
https://www.readbyqxmd.com/read/29544958/reg3%C3%AE-is-associated-with-cardiac-inflammation-and-provides-prognostic-information-in-patients-with-acute-coronary-syndrome
#7
Holger Lörchner, Christian Widera, Yunlong Hou, Albrecht Elsässer, Henning Warnecke, Evangelos Giannitsis, Jean-Sebastien Hulot, Thomas Braun, Kai C Wollert, Jochen Pöling
BACKGROUND: Regenerating islet-derived protein 3 beta (Reg3β) is a cardiomyocyte-derived chemokine for macrophages that is upregulated after myocardial infarction (MI) in mice. Here, we hypothesized that monitoring Reg3β expression might provide specific information on the degree of cardiac inflammation, which is a key determinant in disease progression and prognosis of patients with acute coronary syndrome (ACS). METHODS AND RESULTS: The expression of Reg3β and other inflammatory markers including C-reactive protein (CRP) and myeloperoxidase (MPO) was measured by immunoblotting at serial time points in the hearts and serum of mice with acute MI...
May 1, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29529688/levels-of-nitric-oxide-metabolites-and-myeloperoxidase-in-subjects-with-type-2-diabetes-mellitus-on-metformin-therapy
#8
Nevenka Jelić-Knezović, Semira Galijašević, Mila Lovrić, Marina Vasilj, Sanja Selak, Ivanka Mikulić
INTRODUCTION: Endothelial dysfunction is involved in the pathogenesis of insulin resistance, diabetes mellitus type 2, diabetic complications and preceded clinical manifestation of cardiovascular complications. Increased myeloperoxidase activity has been linked to a number of pathologies with compelling evidence in initiation and progression of inflammatory events. The aim of this study was to compare concentrations of metabolite nitric oxide and myeloperoxidase in the plasma of diabetes mellitus type 2 patients on metformin therapy, without clinical signs of cardiovascular disease and healthy subjects, as well as evaluation of concentrations of analytes in association with glycemic control...
March 12, 2018: Experimental and Clinical Endocrinology & Diabetes
https://www.readbyqxmd.com/read/29507101/mechanistic-role-of-the-calcium-dependent-protease-calpain-in-the-endothelial-dysfunction-induced-by-mpo-myeloperoxidase
#9
Zienab Etwebi, Gavin Landesberg, Kyle Preston, Satoru Eguchi, Rosario Scalia
MPO (myeloperoxidase) is a peroxidase enzyme secreted by activated leukocytes that plays a pathogenic role in cardiovascular disease, mainly by initiating endothelial dysfunction. The molecular mechanisms of the endothelial damaging action of MPO remain though largely elusive. Calpain is a calcium-dependent protease expressed in the vascular wall. Activation of calpains has been implicated in inflammatory disorders of the vasculature. Using endothelial cells and genetically modified mice, this study identifies the µ-calpain isoform as novel downstream signaling target of MPO in endothelial dysfunction...
April 2018: Hypertension
https://www.readbyqxmd.com/read/29466787/a-strategy-for-optimizing-the-combination-of-active-components-based-on-chinese-medicinal-formula-sheng-mai-san-for-myocardial-ischemia
#10
Fang Li, Xiao-Xue Fan, Chun Chu, Yu Zhang, Jun-Ping Kou, Bo-Yang Yu
BACKGROUND/AIMS: Traditional Chinese medicine (TCM) has been used in clinical practice for thousands of years and has accumulated considerable knowledge concerning the in vivo efficacy of targeting complicated diseases. TCM formulae are a mixture of hundreds of chemical components with multiple potential targets, essentially acting as a combination therapy of multi-component drugs. However, the obscure substances and the unclear molecular mechanisms are obstacles to their further development and internationalization...
February 16, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29356689/the-impact-of-myeloperoxidase-on-hdl-function-in-myocardial-infarction
#11
Uwe J F Tietge
PURPOSE OF REVIEW: The focus in cardiovascular research is shifting from determining mass HDL cholesterol levels toward investigating HDL functionalities as biomarker for cardiovascular disease. Myeloperoxidase (MPO), a main effector enzyme of the innate immune system, is increasingly implicated to negatively impact HDL function by various chemical modifications of HDL-associated proteins. This review summarizes recent insights how MPO affects HDL function in the setting of acute myocardial infarction (MI), mainly focusing on human data...
April 2018: Current Opinion in Endocrinology, Diabetes, and Obesity
https://www.readbyqxmd.com/read/29343081/atorvastatin-reduces-plasma-inflammatory-and-oxidant-biomarkers-in-patients-with-risk-of-atherosclerotic-cardiovascular-disease
#12
Fadia Mayyas, Duha Baydoun, Rasheed Ibdah, Khalid Ibrahim
BACKGROUND: Oxidative stress and inflammation are associated with endothelial injury and coronary artery disease. Inflammatory factors that promote oxidative damage include endothelin-1 (ET-1), myeloperoxidase (MPO), and C-reactive protein (CRP). Current guidelines recommend the use of statins in patients with risk of atherosclerotic cardiovascular disease (ASCVD). AIM: To assess the impact of atorvastatin on plasma inflammatory and oxidant biomarkers in patients with moderate to very high risk of ASCVD...
January 1, 2018: Journal of Cardiovascular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29333048/astaxanthin-ameliorates-hepatic-damage-and-oxidative-stress-in-carbon-tetrachloride-administered-rats
#13
Md Ariful Islam, Md Abdullah Al Mamun, Md Faruk, Md Tauhid Ul Islam, Md Mizanur Rahman, Mohammad Nazmul Alam, A F M Towheedur Rahman, Hasan Mahmud Reza, Md Ashraful Alam
Background: Astaxanthin is of carotenoids group which possess strong antioxidant properties. The present study was conducted to evaluate the hepatoprotective effects of astaxanthin in carbon tetrachloride (CCl4 )-treated rats. Materials and Methods: Female Long-Evans rats were administered with CCl4 orally (1 ml/kg) twice a week for 2 weeks and were treated with astaxanthin (10 mg/kg) every day for 2 weeks. Blood plasma samples were isolated from each group and were analyzed for alanine aminotransferase (ALT), aspartate aminotransferase (AST), and alkaline phosphatase activities...
December 2017: Pharmacognosy Research
https://www.readbyqxmd.com/read/29320971/the-effect-of-nutritional-intervention-on-the-lipid-profile-and-dietary-intake-of-adolescents-with-juvenile-systemic-lupus-erythematosus-a-randomized-controlled-trial
#14
S G L da Silva, M T Terreri, T T O Abad, D Machado, F L A Fonseca, S Hix, F I Suano-Souza, R O S Sarni, C A Len
Objective This study sought to evaluate the effects of a nutritional intervention on the lipid metabolism biomarkers associated with cardiovascular risk, and their variation over time, in juvenile systemic lupus erythematosus (JSLE) patients. This study also investigated the relationships between these biomarkers and dietary intake, nutritional status, disease variables, and medication used. Methods A total of 31 10- to 19-year-old female adolescents with JSLE for at least six months were analyzed. The participants were randomly allocated to two groups: nutritional intervention or control...
April 2018: Lupus
https://www.readbyqxmd.com/read/29277016/apolipoprotein-a-1-mimetic-peptide-4f-promotes-endothelial-repairing-and-compromises-reendothelialization-impaired-by-oxidized-hdl-through-sr-b1
#15
Dan He, Mingming Zhao, Congying Wu, Wenjing Zhang, Chenguang Niu, Baoqi Yu, Jingru Jin, Liang Ji, Belinda Willard, Anna V Mathew, Y Eugene Chen, Subramaniam Pennathur, Huiyong Yin, Yuan He, Bing Pan, Lemin Zheng
Disruption of endothelial monolayer integrity is the primary instigating factor for many cardiovascular diseases. High density lipoprotein (HDL) oxidized by heme enzyme myeloperoxidase (MPO) is dysfunctional in promoting endothelial repair. Apolipoprotein A-1 mimetic 4F with its pleiotropic benefits has been proven effective in many in vivo models. In this study we investigated whether 4F promotes endothelial repair and restores the impaired function of oxidized HDL (Cl/NO2 -HDL) in promoting re-endothelialization...
May 2018: Redox Biology
https://www.readbyqxmd.com/read/29247550/melatonin-prevents-hypochlorous-acid-mediated-cyanocobalamin-destruction-and-cyanogen-chloride-generation
#16
Roohi Jeelani, Dhiman Maitra, Charalampos Chatzicharalampous, Syed Najeemuddin, Robert T Morris, Husam M Abu-Soud
Hypochlorous acid (HOCl) is a potent cytotoxic oxidant generated by the enzyme myeloperoxidase (MPO) in the presence of hydrogen peroxide (H2 O2 ) and chloride (Cl- ). Elevated levels of HOCl play an important role in various pathological conditions through oxidative modification of several biomolecules. Recently, we have highlighted the ability of HOCl to mediate the destruction of the metal-ion derivatives of tetrapyrrole macrocyclic rings such as hemoproteins and vitamin B12 (VB12 ) derivatives. Destruction of cyanocobalamin, a common pharmacological form of VB12 mediated by HOCl, results in the generation of toxic molecular products such as chlorinated derivatives, corrin ring cleavage products, the toxic blood agents cyanide (CN- ) and cyanogen chloride (CNCl), and redox-active free cobalt...
April 2018: Journal of Pineal Research
https://www.readbyqxmd.com/read/29241061/scfv-modified-graphene-coated-ide-arrays-for-label-free-screening-of-cardiovascular-disease-biomarkers-in-physiological-saline
#17
Lotta E Delle, Vivek Pachauri, Shikha Sharma, Olena Shaforost, Hui Ma, Mohammad Adabi, Rainer Lilischkis, Patrick Wagner, Ronald Thoelen, Norbert Klein, Richard O'Kennedy, Sven Ingebrandt
Fatty-acid binding proteins (FABP) and myeloperoxidases (MPO) are associated with many chronic conditions in humans and considered to be important biomarkers for diagnosis of cardiac diseases. Here we assemble a new electrical biosensor platform based on graphene-coated interdigitated electrode arrays (IDE-arrays) towards ultrafast, label-free screening of heart type-FABP and MPO. Arrays of nanoscale (nanoIDE) and microscale (microIDE) electrode-arrays were fabricated on wafer-scale by combining nanoimprint and photolithography processes...
April 15, 2018: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29163665/chlorinative-stress-in-age-related-diseases-a-literature-review
#18
REVIEW
Marco Casciaro, Eleonora Di Salvo, Elisabetta Pace, Elvira Ventura-Spagnolo, Michele Navarra, Sebastiano Gangemi
Aging is an agglomerate of biological long-lasting processes that result being inevitable. Main actors in this scenario are both long-term inflammation and oxidative stress. It has been proved that oxidative stress induce alteration in proteins and this fact itself is critically important in the pathophysiological mechanisms leading to diseases typical of aging. Among reactive species, chlorine ones such as hypochlorous acid (HOCl) are cytotoxic oxidants produced by activated neutrophils during chronic inflammation processes...
2017: Immunity & Ageing: I & A
https://www.readbyqxmd.com/read/29149817/high-density-lipoprotein-hdl-dysfunction-and-future-of-hdl
#19
Sibel Ertek
Although high density lipoprotein cholesterol (HDL-C) levels are inversely proportional to cardiovascular risk in many studies, recent pharmacological interventional studies with HDL-C raising strategies did not show a benefit in terms of vascular events. The HDL particle is heterogenous with anti-atherogenic functions and non-vascular effects. Many factors affect HDL components and may either cause compositional changes, post-translational modifications of proteins, or alter lipids and other cargo molecules; generally these factors cause more than one of these changes, resulting in functional differences...
November 16, 2017: Current Vascular Pharmacology
https://www.readbyqxmd.com/read/28899512/nepeta-deflersiana-attenuates-isoproterenol-induced-myocardial-injuries-in-rats-possible-involvement-of-oxidative-stress-apoptosis-inflammation-through-nuclear-factor-nf-%C3%AE%C2%BAb-downregulation
#20
Areej Mohammad Al-Taweel, Mohammad Raish, Shagufta Perveen, Ghada Ahmed Fawzy, Ajaz Ahmad, Mushtaq Ahmad Ansari, Shahid Mudassar, Majid Ahmad Ganaie
BACKGROUND: Nepeta deflersiana (Lamiaceae) is a perennial herb used in the Saudi and Yemeni folk medicine as an anti-inflammatory, carminative, and antirheumatic agent. PURPOSE: This study explores the phytochemistry of the plant and the cardioprotective effect of N. deflersiana ethanolic extract (NDEE) against isoproterenol (ISP)-induced myocardial injury in rats. DESIGN/METHODS: Cardiac function, serum cardiac enzymes, myocardial antioxidants, inflammatory, and apoptotic biomarkers, and histopathological parameters were studied in ISP-injured Wistar rat heart tissues...
October 15, 2017: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
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