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MPO and cardiovascular disease

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https://www.readbyqxmd.com/read/29356689/the-impact-of-myeloperoxidase-on-hdl-function-in-myocardial-infarction
#1
Uwe J F Tietge
PURPOSE OF REVIEW: The focus in cardiovascular research is shifting from determining mass HDL cholesterol levels toward investigating HDL functionalities as biomarker for cardiovascular disease. Myeloperoxidase (MPO), a main effector enzyme of the innate immune system, is increasingly implicated to negatively impact HDL function by various chemical modifications of HDL-associated proteins. This review summarizes recent insights how MPO affects HDL function in the setting of acute myocardial infarction (MI), mainly focusing on human data...
January 19, 2018: Current Opinion in Endocrinology, Diabetes, and Obesity
https://www.readbyqxmd.com/read/29343081/atorvastatin-reduces-plasma-inflammatory-and-oxidant-biomarkers-in-patients-with-risk-of-atherosclerotic-cardiovascular-disease
#2
Fadia Mayyas, Duha Baydoun, Rasheed Ibdah, Khalid Ibrahim
BACKGROUND: Oxidative stress and inflammation are associated with endothelial injury and coronary artery disease. Inflammatory factors that promote oxidative damage include endothelin-1 (ET-1), myeloperoxidase (MPO), and C-reactive protein (CRP). Current guidelines recommend the use of statins in patients with risk of atherosclerotic cardiovascular disease (ASCVD). AIM: To assess the impact of atorvastatin on plasma inflammatory and oxidant biomarkers in patients with moderate to very high risk of ASCVD...
January 1, 2018: Journal of Cardiovascular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29333048/astaxanthin-ameliorates-hepatic-damage-and-oxidative-stress-in-carbon-tetrachloride-administered-rats
#3
Md Ariful Islam, Md Abdullah Al Mamun, Md Faruk, Md Tauhid Ul Islam, Md Mizanur Rahman, Mohammad Nazmul Alam, A F M Towheedur Rahman, Hasan Mahmud Reza, Md Ashraful Alam
Background: Astaxanthin is of carotenoids group which possess strong antioxidant properties. The present study was conducted to evaluate the hepatoprotective effects of astaxanthin in carbon tetrachloride (CCl4)-treated rats. Materials and Methods: Female Long-Evans rats were administered with CCl4 orally (1 ml/kg) twice a week for 2 weeks and were treated with astaxanthin (10 mg/kg) every day for 2 weeks. Blood plasma samples were isolated from each group and were analyzed for alanine aminotransferase (ALT), aspartate aminotransferase (AST), and alkaline phosphatase activities...
December 2017: Pharmacognosy Research
https://www.readbyqxmd.com/read/29320971/the-effect-of-nutritional-intervention-on-the-lipid-profile-and-dietary-intake-of-adolescents-with-juvenile-systemic-lupus-erythematosus-a-randomized-controlled-trial
#4
S G L da Silva, M T Terreri, T T O Abad, D Machado, F L A Fonseca, S Hix, F I Suano-Souza, R O S Sarni, C A Len
Objective This study sought to evaluate the effects of a nutritional intervention on the lipid metabolism biomarkers associated with cardiovascular risk, and their variation over time, in juvenile systemic lupus erythematosus (JSLE) patients. This study also investigated the relationships between these biomarkers and dietary intake, nutritional status, disease variables, and medication used. Methods A total of 31 10- to 19-year-old female adolescents with JSLE for at least six months were analyzed. The participants were randomly allocated to two groups: nutritional intervention or control...
January 1, 2018: Lupus
https://www.readbyqxmd.com/read/29277016/apolipoprotein-a-1-mimetic-peptide-4f-promotes-endothelial-repairing-and-compromises-reendothelialization-impaired-by-oxidized-hdl-through-sr-b1
#5
Dan He, Mingming Zhao, Congying Wu, Wenjing Zhang, Chenguang Niu, Baoqi Yu, Jingru Jin, Liang Ji, Belinda Willard, Anna V Mathew, Y Eugene Chen, Subramaniam Pennathur, Huiyong Yin, Yuan He, Bing Pan, Lemin Zheng
Disruption of endothelial monolayer integrity is the primary instigating factor for many cardiovascular diseases. High density lipoprotein (HDL) oxidized by heme enzyme myeloperoxidase (MPO) is dysfunctional in promoting endothelial repair. Apolipoprotein A-1 mimetic 4F with its pleiotropic benefits has been proven effective in many in vivo models. In this study we investigated whether 4F promotes endothelial repair and restores the impaired function of oxidized HDL (Cl/NO2-HDL) in promoting re-endothelialization...
December 8, 2017: Redox Biology
https://www.readbyqxmd.com/read/29247550/melatonin-prevents-hypochlorous-acid-mediated-cyanocobalamin-destruction-and-cyanogen-chloride-generation
#6
Roohi Jeelani, Dhiman Maitra, Charalampos Chatzicharalampous, Syed Najeemuddin, Robert T Morris, Husam M Abu-Soud
Hypochlorous acid (HOCl) is a potent cytotoxic oxidant generated by the enzyme myeloperoxidase (MPO) in the presence of hydrogen peroxide (H2 O2 ) and chloride (Cl- ). Elevated levels of HOCl play an important role in various pathological conditions through oxidative modification of several biomolecules. Recently, we have highlighted the ability of HOCl to mediate the destruction of the metal-ion derivatives of tetrapyrrole macrocyclic rings such as hemoproteins and vitamin B12 (VB12 ) derivatives. Destruction of cyanocobalamin, a common pharmacological form of VB12 mediated by HOCl, results in the generation of toxic molecular products such as chlorinated derivatives, corrin ring cleavage products, the toxic blood agents cyanide (CN- ) and cyanogen chloride (CNCl), and redox-active free cobalt...
December 16, 2017: Journal of Pineal Research
https://www.readbyqxmd.com/read/29241061/scfv-modified-graphene-coated-ide-arrays-for-label-free-screening-of-cardiovascular-disease-biomarkers-in-physiological-saline
#7
Lotta E Delle, Vivek Pachauri, Shikha Sharma, Olena Shaforost, Hui Ma, Mohammad Adabi, Rainer Lilischkis, Patrick Wagner, Ronald Thoelen, Norbert Klein, Richard O'Kennedy, Sven Ingebrandt
Fatty-acid binding proteins (FABP) and myeloperoxidases (MPO) are associated with many chronic conditions in humans and considered to be important biomarkers for diagnosis of cardiac diseases. Here we assemble a new electrical biosensor platform based on graphene-coated interdigitated electrode arrays (IDE-arrays) towards ultrafast, label-free screening of heart type-FABP and MPO. Arrays of nanoscale (nanoIDE) and microscale (microIDE) electrode-arrays were fabricated on wafer-scale by combining nanoimprint and photolithography processes...
December 7, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29163665/chlorinative-stress-in-age-related-diseases-a-literature-review
#8
REVIEW
Marco Casciaro, Eleonora Di Salvo, Elisabetta Pace, Elvira Ventura-Spagnolo, Michele Navarra, Sebastiano Gangemi
Aging is an agglomerate of biological long-lasting processes that result being inevitable. Main actors in this scenario are both long-term inflammation and oxidative stress. It has been proved that oxidative stress induce alteration in proteins and this fact itself is critically important in the pathophysiological mechanisms leading to diseases typical of aging. Among reactive species, chlorine ones such as hypochlorous acid (HOCl) are cytotoxic oxidants produced by activated neutrophils during chronic inflammation processes...
2017: Immunity & Ageing: I & A
https://www.readbyqxmd.com/read/29149817/high-density-lipoprotein-hdl-dysfunction-and-future-of-hdl
#9
Sibel Ertek
Although high density lipoprotein cholesterol (HDL-C) levels are inversely proportional to cardiovascular risk in many studies, recent pharmacological interventional studies with HDL-C raising strategies did not show a benefit in terms of vascular events. The HDL particle is heterogenous with anti-atherogenic functions and non-vascular effects. Many factors affect HDL components and may either cause compositional changes, post-translational modifications of proteins, or alter lipids and other cargo molecules; generally these factors cause more than one of these changes, resulting in functional differences...
November 16, 2017: Current Vascular Pharmacology
https://www.readbyqxmd.com/read/28899512/nepeta-deflersiana-attenuates-isoproterenol-induced-myocardial-injuries-in-rats-possible-involvement-of-oxidative-stress-apoptosis-inflammation-through-nuclear-factor-nf-%C3%AE%C2%BAb-downregulation
#10
Areej Mohammad Al-Taweel, Mohammad Raish, Shagufta Perveen, Ghada Ahmed Fawzy, Ajaz Ahmad, Mushtaq Ahmad Ansari, Shahid Mudassar, Majid Ahmad Ganaie
BACKGROUND: Nepeta deflersiana (Lamiaceae) is a perennial herb used in the Saudi and Yemeni folk medicine as an anti-inflammatory, carminative, and antirheumatic agent. PURPOSE: This study explores the phytochemistry of the plant and the cardioprotective effect of N. deflersiana ethanolic extract (NDEE) against isoproterenol (ISP)-induced myocardial injury in rats. DESIGN/METHODS: Cardiac function, serum cardiac enzymes, myocardial antioxidants, inflammatory, and apoptotic biomarkers, and histopathological parameters were studied in ISP-injured Wistar rat heart tissues...
October 15, 2017: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/28864169/molecular-understanding-of-epigallocatechin-gallate-egcg-in-cardiovascular-and-metabolic-diseases
#11
REVIEW
Qian Yi Eng, Punniyakoti Veeraveedu Thanikachalam, Srinivasan Ramamurthy
ETHNOPHARMACOLOGICAL RELEVANCE: The compound epigallocatechin-3-gallate (EGCG), the major polyphenolic compound present in green tea [Camellia sinensis (Theaceae], has shown numerous cardiovascular health promoting activity through modulating various pathways. However, molecular understanding of the cardiovascular protective role of EGCG has not been reported. AIM OF THE REVIEW: This review aims to compile the preclinical and clinical studies that had been done on EGCG to investigate its protective effect on cardiovascular and metabolic diseases in order to provide a systematic guidance for future research...
January 10, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28818791/low-density-lipoprotein-modified-by-myeloperoxidase-oxidants-induces-endothelial-dysfunction
#12
Adrian I Abdo, Benjamin S Rayner, David M van Reyk, Clare L Hawkins
Low-density lipoprotein (LDL) modified by hypochlorous acid (HOCl) produced by myeloperoxidase (MPO) is present in atherosclerotic lesions, where it is implicated in the propagation of inflammation and acceleration of lesion development by multiple pathways, including the induction of endothelial dysfunction. Thiocyanate (SCN(-)) ions are utilised by MPO to produce the oxidant hypothiocyanous acid (HOSCN), which reacts with LDL in a different manner to HOCl. Whilst the reactivity of HOCl-modified LDL has been previously studied, the role of HOSCN in the modification of LDL in vivo is poorly defined, although emerging evidence suggests that these particles have distinct biological properties...
August 5, 2017: Redox Biology
https://www.readbyqxmd.com/read/28783097/role-of-salivary-biomarkers-in-detection-of-cardiovascular-diseases-cvd
#13
REVIEW
Saad Abdul Rehman, Zohaib Khurshid, Fayez Hussain Niazi, Mustafa Naseem, Hamed Al Waddani, Haafsa Arshad Sahibzada, Rabia Sannam Khan
Human whole mouth saliva (WMS) is secreted by salivary glands, namely parotid, submandibular/sublingual and other minor glands of the oral cavity. It is secreted in a systematic way, and contain informative proteins and peptides for the early detection of contagious diseases and organ-related diseases. The role of WMS as a liquid biopsy for the detection of cardiovascular diseases (CVD) through Myoglobin (MYO), Cardiac troponin I (cTnI), Creatine phosphokinase MB (CK-MB), Myeloperoxidase (MPO), brain natriuretic peptide (NT-proBNP), Exosomal miRNA, C-Reactive Protein (CRP), Matrix metalloproteinase-8 (MMP-8), MMP-9 and tissue inhibitor of MMP-8 (TIMP-1), leukotriene B4 has been well reported in last decade, that have been reviewed in the literature comprehensively below...
August 7, 2017: Proteomes
https://www.readbyqxmd.com/read/28713008/determining-myeloperoxidase-activity-and-protein-concentration-in-a-single-assay-utility-in-biomarker-and-therapeutic-studies
#14
Muir Russell, Nina Prokoph, Neil Henderson, Susanna Eketjäll, Clare A Balendran, Erik Michaëlsson, Mark Fidock, Glen Hughes
Myeloperoxidase (MPO) is predominantly expressed by neutrophils and is an important enzyme used by the immune system for the neutralisation of bacteria and other microorganisms. The strong oxidative activity of MPO has been linked to pro-inflammatory responses in surrounding cells and tissues with implication in the pathophysiology of cardiovascular, neuroscience and inflammatory diseases. This broad disease association has made MPO an attractive biomarker and therapeutic target. Here we describe the construction and validation of a single combined MPO activity and protein concentration assay using commercially available reagents...
October 2017: Journal of Immunological Methods
https://www.readbyqxmd.com/read/28686951/the-association-between-total-phthalate-concentration-and-non-communicable-diseases-and-chronic-inflammation-in-south-australian-urban-dwelling-men
#15
Peter Y Bai, Gary Wittert, Anne W Taylor, Sean A Martin, Robert W Milne, Alicia J Jenkins, Andrzej S Januszewski, Zumin Shi
OBJECTIVE: To investigate associations between urinary total phthalate concentration, chronic low-grade inflammation and non-communicable diseases in a cohort of South Australian men. METHODS: 1504 men aged 39-84 years who provided a urinary sample at the follow-up visit of the Men Androgen Inflammation Lifestyle Environment and Stress (MAILES) study, a randomly-selected group of urban-dwelling, community-based men from Adelaide, Australia (n = 2038; study participation rate: 78...
October 2017: Environmental Research
https://www.readbyqxmd.com/read/28678311/regulation-of-mir-92a-on-vascular-endothelial-aging-via-mediating-nrf2-keap1-are-signal-pathway
#16
H Liu, H-Y Wu, W-Y Wang, Z-L Zhao, X-Y Liu, L-Y Wang
OBJECTIVE: Various human aging-related diseases start with vascular aging, in which the aging of vascular endothelium is the first step to cause a structural and functional deficit of vascular endothelium, leading to vascular disorders. MicroRNA (miR) participates in various processes of body development and pathological processes via mediating cell proliferation, differentiation, and apoptosis. A previous study showed the correlation between cardiovascular disease and miR-92a, whose role and mechanism in vascular endothelial aging has not been reported...
June 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28645072/association-of-the-serum-myeloperoxidase-high-density-lipoprotein-particle-ratio-and-incident-cardiovascular-events-in-a-multi-ethnic-population-observations-from-the-dallas-heart-study
#17
Htet W Khine, John F Teiber, Robert W Haley, Amit Khera, Colby R Ayers, Anand Rohatgi
BACKGROUND AND AIMS: Myeloperoxidase (MPO), a product of systemic inflammation, promotes oxidation of lipoproteins; whereas, high-density lipoprotein (HDL) exerts anti-oxidative effects in part via paraoxonase-1 (PON1). MPO induces dysfunctional HDL particles; however, the interaction of circulating levels of these measures in cardiovascular disease (CVD) has not been studied in humans. We tested whether serum levels of MPO indexed to HDL particle concentration (MPO/HDLp) are associated with increased CVD risk in a large multiethnic population sample, free of CVD at baseline...
August 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28552694/mesna-2-mercaptoethane-sodium-sulfonate-functions-as-a-regulator-of-myeloperoxidase
#18
Roohi Jeelani, Seyedehameneh Jahanbakhsh, Hamid-Reza Kohan-Ghadr, Mili Thakur, Sana Khan, Sarah R Aldhaheri, Zhe Yang, Peter Andreana, Robert Morris, Husam M Abu-Soud
Myeloperoxidase (MPO), an abundant protein in neutrophils, monocytes, and macrophages, is thought to play a critical role in the pathogenesis of various disorders ranging from cardiovascular diseases to cancer. We show that mesna (2-mercaptoethanesulfonic acid sodium salt), a detoxifying agent, which inhibits side effects of oxazaphosphorine chemotherapy, functions as a potent inhibitor of MPO; modulating its catalytic activity and function. Using rapid kinetic methods, we examined the interactions of mesna with MPO compounds I and II and ferric forms in the presence and absence of chloride (Cl(-)), the preferred substrate of MPO...
May 25, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/28550240/the-role-of-gst-polymorphism-in-reperfusion-induced-oxidative-stress-inflammatory-responses-and-clinical-complications-after-surgical-and-percutaneous-coronary-intervention
#19
Örs Pintér, Péter Hardi, Tibor Nagy, Balázs Gasz, Viktoria Kovács, Endre Arató, László Sínay, László Lénárd, Gábor Jancsó
BACKGROUND: Patients having coronary artery disease treated by coronary bypass or PCI procedure are exposed to tissue damage because of the phenomenon called reperfusion injury. Reperfusion injury can be characterized/monitored by oxidative stress parameters, inflammatory markers and by post-operative complication rate. OBJECTIVE: Beyond the obvious factors determining its severity (affected myocardial mass, ischaemic time, collateral circulation etc.) we examined the GST enzyme group's most cardio selective member, GSTP1 and its genetic polymorphism if there is any genetically determined preventive effect on the above-mentioned parameters...
May 24, 2017: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/28489953/vascular-function-and-arginine-and-dimethylarginines-in-gentamicin-induced-renal-failure-a-possible-effect-of-heme-oxygenase-1-inducer-hemin
#20
Esra Aycan-Ustyol, Merve Kabasakal, Seldag Bekpinar, F Ilkay Alp-Yıldırım, Ozge Tepe, Murat Giris, Yasemin Ozluk, Yesim Unlucerci, B Sonmez Uydes-Dogan, Mujdat Uysal
Increased oxidative stress and disturbance in nitric oxide bioavailability lead to endothelial dysfunction and cardiovascular complication in renal disease. Gentamicin (GM), a commonly used antibiotic, exhibits a toxic effect on renal proximal tubules. Prevention of its nephrotoxicity is important. Therefore, we investigated whether heme oxygenase 1 HO-1) induction influenced kidney and vascular function in GM-administered rats. GM (100 mg·kg(-1)·day(-1); i.p.) was given to rats alone or together with hemin (20 mg·kg(-1) on alternate days; i...
May 10, 2017: Canadian Journal of Physiology and Pharmacology
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