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MPO and cardiovascular disease

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https://www.readbyqxmd.com/read/27814628/inflammatory-biomarkers-of-coronary-heart-disease
#1
Hongyu Li, Kai Sun, Ruiping Zhao, Jiang Hu, Zhiru Hao, Fei Wang, Yaojun Lu, Fu Liu, Yong Zhang
Coronary heart disease (CHD), characterized by inflammation and accumulation of plaques mainly comprised of lipids, calcium and inflammatory cells in the walls of coronary arteries. CHD is exacerbated by specific cardiovascular risk factors, such as obesity, diabetes mellitus, and hypertension. The current review focuses on the critical role of traditional inflammatory biomarkers, including interleukin-6, C-reactive protein (CRP), complement, CD40 and myeloperoxidase (MPO), in the pathogenesis of CHD.
January 1, 2017: Frontiers in Bioscience (Landmark Edition)
https://www.readbyqxmd.com/read/27782743/the-labile-iron-pool-in-monocytes-reflects-the-activity-of-the-atherosclerotic-process-in-men-with-chronic-cardiovascular-disease
#2
P Riško, J Pláteník, R Buchal, J Potočková, P J Kraml
The study investigates the relationship between the labile iron pool (LIP) in circulating monocytes and markers of iron metabolism, inflammation, oxidative stress, endothelial dysfunction and arterial elasticity in patients with chronic cardiovascular disease and in healthy volunteers. The patients with a history of CVEs had significantly higher LIP values than did the control group (1.94+/-0.46 microM vs. 1.62+/-0.49 microM, p=0.02). Except for the leukocyte number (WBCs), the groups did not differ in other inflammatory markers (CRPus, CD 163, MPO, MMP-1)...
October 26, 2016: Physiological Research
https://www.readbyqxmd.com/read/27496081/reduced-levels-of-potential-circulating-biomarkers-of-cardiovascular-diseases-in-apparently-healthy-vegetarian-men
#3
Julio Acosta Navarro, Luiza Antoniazzi de Gouveia, Lilliam Rocha-Penha, Naiara Cinegaglia, Vanessa Belo, Michele Mazzaron de Castro, Valeria Cristina Sandrim
BACKGROUND: Several evidences report that a vegetarian diet is protector against cardiovascular diseases. Few studies have demonstrated the circulating profile of cardiovascular biomarkers in vegetarians. Therefore, the aims of the current study were compared the plasma concentrations of myeloperoxidase (MPO), metalloproteinase (MMP)-9, MMP-2, tissue inhibitor of MMP (TIMP)-1 and TIMP-2 between healthy vegetarian (Veg) and healthy omnivorous (Omn). METHODS: Using ELISA and multiplexed bead immunoassay, we measured in plasma from 43 Veg and 41 Omn the cardiovascular biomarkers concentrations cited above...
October 1, 2016: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/27472294/epigallocatechin-gallate-potentially-abrogates-fluoride-induced-lung-oxidative-stress-inflammation-via-nrf2-keap1-signaling-pathway-in-rats-an-in-vivo-and-in-silico-study
#4
Thangapandiyan Shanmugam, Miltonprabu Selvaraj, Senthilraja Poomalai
BACKGROUND: Since this Nrf2-dependent cellular defense response is able to protect multi-organs, including cancer, neurodegenerative diseases, cardiovascular diseases, inflammation and chronic lung injury. The antioxidant and anti-inflammatory potential of Epigallocatechin gallate (EGCG) and Nrf2/Keap1 signaling mechanisms in pulmonary toxicity have not been clarified. In the present study, we demonstrated that protective efficacy of EGCG against fluoride (Fl) induced oxidative stress mediated lung injury in rats...
October 2016: International Immunopharmacology
https://www.readbyqxmd.com/read/27441256/roles-of-myeloperoxidase-and-gapdh-in-interferon-gamma-production-of-gm-csf-dependent-macrophages
#5
Rui Yamaguchi, Takatoshi Yamamoto, Arisa Sakamoto, Yasuji Ishimaru, Shinji Narahara, Hiroyuki Sugiuchi, Yasuo Yamaguchi
Interferon (IFN)-gamma is highly expressed in atherosclerotic lesions and may have an important role in atherogenesis. Myeloperoxidase (MPO), the most abundant protein in neutrophils, is a marker of plaque vulnerability and a possible bridge between inflammation and cardiovascular disease. Granulocyte-macrophage colony-stimulating factor (GM-CSF) has also been implicated in the pathogenesis of atherosclerosis. The present study investigated the role of neutrophil activation in atherosclerosis. Adherent macrophages were obtained from primary cultures of human mononuclear cells...
February 2016: Heliyon
https://www.readbyqxmd.com/read/27420626/-myeloperoxidase-activity-in-blood-plasma-as-a-criterion-of-therapy-for-patients-with-cardiovascular-disease
#6
D V Grigorieva, I V Gorudko, V A Kostevich, A V Sokolov, I V Buko, V B Vasilyev, L Z Polonetsky, O M Panasenko, S N Cherenkevich
A significant increase in the myeloperoxidase (MPO) activity has been found in plasma of patients with stable angina and with acute coronary syndrome (ACS) in comparison with the control group. MPO concentration was significantly increased in plasma of ACS patients. Reduced MPO activity in the treated ACS patients correlated with a favorable outcome of the disease. Generally, changes in plasma MPO concentration coincided with changes in lactoferrin concentration thus confirming the role of neutrophil degranulation in the increase of plasma concentrations of these proteins...
March 2016: Biomedit︠s︡inskai︠a︡ Khimii︠a︡
https://www.readbyqxmd.com/read/27342818/effects-of-atorvastatin-on-atrial-remodeling-in-a-rabbit-model-of-atrial-fibrillation-produced-by-rapid-atrial-pacing
#7
Qian Yang, Xiaoyong Qi, Yi Dang, Yingxiao Li, Xuelian Song, Xiao Hao
BACKGROUND: Accumulating evidence suggests that myeloperoxidase (MPO) is involved in atrial remodeling of atrial fibrillation (AF). Statins could reduce the MPO levels in patients with cardiovascular diseases. This study evaluated the effects of atorvastatin on MPO level and atrial remodeling in a rabbit model of pacing-induced AF. METHODS: Eighteen rabbits were randomly divided into sham, control and atorvastatin groups. Rabbits in the control and atorvastatin groups were subjected to rapid atrial pacing (RAP) at 600 bpm for 3 weeks, and treated with placebo or atorvastatin (2...
2016: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/27178483/a-novel-sensor-to-estimate-the-prevalence-of-hypochlorous-hocl-toxicity-in-individuals-with-type-2-diabetes-and-dyslipidemia
#8
Kakali Ghoshal, Sangita Das, Krishnendu Aich, Shyamaprosad Goswami, Subhankar Chowdhury, Maitree Bhattacharyya
BACKGROUND: Oxidative stress is common in type 2 diabetes. It is characterised by increased levels of reactive oxygen species (ROS), of which hypochlorous acid (HOCl) is an important component. Type 2 diabetes is characterised not only by hyperglycemia, but also by dyslipidemia. It probably underlies both the development of diabetes and also resulting complications, like cardiovascular disease. We applied a novel fluoroprobe RHQ to estimate endogenous HOCl and myeloperoxidase (MPO) activity in diabetes and dyslipidemia...
July 1, 2016: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/27127544/role-of-myeloperoxidase-in-patients-with-chronic-kidney-disease
#9
REVIEW
Bojana Kisic, Dijana Miric, Ilija Dragojevic, Julijana Rasic, Ljiljana Popovic
Chronic kidney disease (CKD) is a worldwide public health problem. Patients with CKD have a number of disorders in the organism, and the presence of oxidative stress and systemic inflammation in these patients is the subject of numerous studies. Chronic inflammation joined with oxidative stress contributes to the development of numerous complications: accelerated atherosclerosis process and cardiovascular disease, emergence of Type 2 diabetes mellitus, development of malnutrition, anaemia, hyperparathyroidism, and so forth, affecting the prognosis and quality of life of patients with CKD...
2016: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/27091532/oxidative-stress-and-inflammation-differentially-elevated-in-objective-versus-habitual-subjective-reduced-sleep-duration-in-obstructive-sleep-apnea
#10
Theresanne DeMartino, Rawad El Ghoul, Lu Wang, James Bena, Stanley L Hazen, Russel Tracy, Sanjay R Patel, Dennis Auckley, Reena Mehra
STUDY OBJECTIVES: Data have demonstrated adverse health effects of sleep deprivation. We postulate that oxidative stress and systemic inflammation biomarkers will be elevated in relation to short-term and long-term sleep duration reduction. METHODS: We analyzed data from the baseline examination of a randomized controlled trial involving participants with moderate to severe obstructive sleep apnea (OSA). Baseline polysomnography provided the total sleep time (PSG-TST, primary predictor); self-reported habitual sleep duration (SR-HSD) data was collected...
July 1, 2016: Sleep
https://www.readbyqxmd.com/read/27016886/assessment-of-oxidative-stress-and-inflammation-in-prediabetes-a-hospital-based-cross-sectional-study
#11
Ashish Agarwal, Anupama Hegde, Charu Yadav, Afzal Ahmad, Poornima A Manjrekar, Rukmini M Srikantiah
BACKGROUND AND AIM: Prediabetes is associated with dysglycemia, obesity, inflammation and endothelial dysfunction, contributing towards the pathogenesis of cardiovascular diseases rendering them vulnerable for the same. The current study intended to explore the risk of cardiovascular disease (CVD) related with prediabetes by assessing oxidative stress and inflammation using serum interleukin-6 (IL-6), myeloperoxidase (MPO) and urine microalbumin (MA) and their correlation with fasting plasma glucose (FPG) and physical measurements...
April 2016: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/27007571/insulin-resistance-in-pcos-patients-enhances-oxidative-stress-and-leukocyte-adhesion-role-of-myeloperoxidase
#12
Victor M Victor, Susana Rovira-Llopis, Celia Bañuls, Noelia Diaz-Morales, Arantxa Martinez de Marañon, Cesar Rios-Navarro, Angeles Alvarez, Marcelino Gomez, Milagros Rocha, Antonio Hernández-Mijares
Cardiovascular diseases and oxidative stress are related to polycystic ovary syndrome (PCOS) and insulin resistance (IR). We have evaluated the relationship between myeloperoxidase (MPO) and leukocyte activation in PCOS patients according to homeostatic model assessment of IR (HOMA-IR), and have explored a possible correlation between these factors and endocrine and inflammatory parameters. This was a prospective controlled study conducted in an academic medical center. The study population consisted of 101 PCOS subjects and 105 control subjects...
2016: PloS One
https://www.readbyqxmd.com/read/26942201/advanced-glycation-end-products-induce-obesity-and-hepatosteatosis-in-cd-1-wild-type-mice
#13
Wael N Sayej, Paul R Knight Iii, Weidun Alan Guo, Barbara Mullan, Patricia J Ohtake, Bruce A Davidson, Abdur Khan, Robert D Baker, Susan S Baker
AGEs are a heterogeneous group of molecules formed from the nonenzymatic reaction of reducing sugars with free amino groups of proteins, lipids, and/or nucleic acids. AGEs have been shown to play a role in various conditions including cardiovascular disease and diabetes. In this study, we hypothesized that AGEs play a role in the "multiple hit hypothesis" of nonalcoholic fatty liver disease (NAFLD) and contribute to the pathogenesis of hepatosteatosis. We measured the effects of various mouse chows containing high or low AGE in the presence of high or low fat content on mouse weight and epididymal fat pads...
2016: BioMed Research International
https://www.readbyqxmd.com/read/26935006/relationship-between-plasma-bilirubin-level-and-oxidative-stress-markers-in-hiv-infected-patients-on-atazanavir-vs-efavirenz-based-antiretroviral-therapy
#14
V Estrada, S Monge, M D Gómez-Garre, P Sobrino, M Masiá, J Berenguer, J Portilla, C Viladés, E Martínez, J R Blanco
OBJECTIVES: Chronic oxidative stress (OS) may play a role in cardiovascular disease in HIV-infected patients, and increased bilirubin levels may have a beneficial role in counteracting OS. Atazanavir (ATV) inhibits UDP-glucuronosyl-transferase 1A1 (UGT1A1), thus increasing unconjugated bilirubin levels. We aimed to compare changes in OS markers in patients on ATV/ritonavir (ATV/r)- vs. efavirenz (EFV)-based first-line antiretroviral therapy (ART). METHODS: A multicentre, prospective cohort study of HIV-infected patients who started first-line ART with either ATV/r or EFV was conducted...
October 2016: HIV Medicine
https://www.readbyqxmd.com/read/26837749/exposure-of-aconitase-to-smoking-related-oxidants-results-in-iron-loss-and-increased-iron-response-protein-1-activity-potential-mechanisms-for-iron-accumulation-in-human-arterial-cells
#15
Jihan Talib, Michael J Davies
Smokers have an elevated risk of cardiovascular disease, but the origin(s) of this increased risk are incompletely defined. Evidence supports an accumulation of the oxidant-generating enzyme myeloperoxidase (MPO) in the inflamed artery wall, and smokers have high levels of SCN(-), a preferred MPO substrate, with this resulting in HOSCN formation. We hypothesised that HOSCN, a thiol-specific oxidant may target the iron-sulphur cluster of aconitase (both isolated, and within primary human coronary artery endothelial cells; HCAEC) resulting in enzyme dysfunction, release of iron, and conversion of the cytosolic isoform to iron response protein-1, which regulates intracellular iron levels...
June 2016: Journal of Biological Inorganic Chemistry: JBIC
https://www.readbyqxmd.com/read/26797862/biomarkers-in-obesity-serum-myeloperoxidase-and-traditional-cardiac-risk-parameters
#16
D C K Borato, G C Parabocz, J T Ribas, H P Netto, F C Erdmann, L D Wiecheteck, F A Manente, L R de Almeida Mello, C Belló, F André dos Santos, L M Borba, J C R Vellosa
BACKGROUND: Chronic low-grade inflammation, combined with traditional cardiovascular risk factors, is common in obesity, providing systemic inflammation that is associated with increased cardiovascular risk. Studies have shown serum mieloperoxidase as a potential biomarker and its clinical applicability for evaluating cardiovascular risk. This study aimed to evaluate the MPO in obese individuals, with or without systemic inflammation and potential cardiovascular risk, as well as correlating MPO with some classic cardiovascular risk parameters...
January 2016: Experimental and Clinical Endocrinology & Diabetes
https://www.readbyqxmd.com/read/26776662/-ajwa-dates-phoenix-dactylifera-l-extract-ameliorates-isoproterenol-induced-cardiomyopathy-through-downregulation-of-oxidative-inflammatory-and-apoptotic-molecules-in-rodent-model
#17
Mohammed Al-Yahya, Mohammad Raish, Mansour S AlSaid, Ajaz Ahmad, Ramzi A Mothana, Mohammed Al-Sohaibani, Mohammed S Al-Dosari, Mohammad K Parvez, Syed Rafatullah
BACKGROUND/PURPOSE: Ajwa, a special variety of Saudi Arabian dates (Phoenix dactylifera L.) is a rich source of nutrients, fibers and bioactive molecules. While previous studies have shown the therapeutic value of dates phytoconstituents in liver and kidney diseases etc., its cardioprotective potential remains elusive. We therefore, investigated the cardioprotective effect of lyophilized Ajwa extract (AJLE) ex vivo as well as in vivo. METHODS: Ex vivo cardioprotective effect of AJLE was evaluated on DCFH-toxicated cardiomyoblast cells (H9C2)...
October 15, 2016: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/26648662/plasma-nitration-of-high-density-and-low-density-lipoproteins-in-chronic-kidney-disease-patients-receiving-kidney-transplants
#18
Ahmed Bakillah, Fasika Tedla, Isabelle Ayoub, Devon John, Allen J Norin, M Mahmood Hussain, Clinton Brown
BACKGROUND: Functional abnormalities of high-density lipoprotein (HDL) could contribute to cardiovascular disease in chronic kidney disease patients. We measured a validated marker of HDL dysfunction, nitrated apolipoprotein A-I, in kidney transplant recipients to test the hypothesis that a functioning kidney transplant reduces serum nitrated apoA-I concentrations. METHODS: Concentrations of nitrated apoA-I and apoB were measured using indirect sandwich ELISA assays on sera collected from each transplant subject before transplantation and at 1, 3, and 12 months after transplantation...
2015: Mediators of Inflammation
https://www.readbyqxmd.com/read/26509551/discovery-of-2-6-5-chloro-2-methoxyphenyl-4-oxo-2-thioxo-3-4-dihydropyrimidin-1-2h-yl-acetamide-pf-06282999-a-highly-selective-mechanism-based-myeloperoxidase-inhibitor-for-the-treatment-of-cardiovascular-diseases
#19
Roger B Ruggeri, Leonard Buckbinder, Scott W Bagley, Philip A Carpino, Edward L Conn, Matthew S Dowling, Dilinie P Fernando, Wenhua Jiao, Daniel W Kung, Suvi T M Orr, Yingmei Qi, Benjamin N Rocke, Aaron Smith, Joseph S Warmus, Yan Zhang, Daniel Bowles, Daniel W Widlicka, Heather Eng, Tim Ryder, Raman Sharma, Angela Wolford, Carlin Okerberg, Karen Walters, Tristan S Maurer, Yanwei Zhang, Paul D Bonin, Samantha N Spath, Gang Xing, David Hepworth, Kay Ahn, Amit S Kalgutkar
Myeloperoxidase (MPO) is a heme peroxidase that catalyzes the production of hypochlorous acid. Clinical evidence suggests a causal role for MPO in various autoimmune and inflammatory disorders including vasculitis and cardiovascular and Parkinson's diseases, implying that MPO inhibitors may represent a therapeutic treatment option. Herein, we present the design, synthesis, and preclinical evaluation of N1-substituted-6-arylthiouracils as potent and selective inhibitors of MPO. Inhibition proceeded in a time-dependent manner by a covalent, irreversible mechanism, which was dependent upon MPO catalysis, consistent with mechanism-based inactivation...
November 12, 2015: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/26323267/dysfunctional-hdl-and-atherosclerotic-cardiovascular-disease
#20
REVIEW
Robert S Rosenson, H Bryan Brewer, Benjamin J Ansell, Philip Barter, M John Chapman, Jay W Heinecke, Anatol Kontush, Alan R Tall, Nancy R Webb
High-density lipoproteins (HDLs) protect against atherosclerosis by removing excess cholesterol from macrophages through the ATP-binding cassette transporter A1 (ABCA1) and ATP-binding cassette transporter G1 (ABCG1) pathways involved in reverse cholesterol transport. Factors that impair the availability of functional apolipoproteins or the activities of ABCA1 and ABCG1 could, therefore, strongly influence atherogenesis. HDL also inhibits lipid oxidation, restores endothelial function, exerts anti-inflammatory and antiapoptotic actions, and exerts anti-inflammatory actions in animal models...
January 2016: Nature Reviews. Cardiology
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