Tia C L Kohs, Helen H Vu, Kelley R Jordan, Iván Parra-Izquierdo, Monica T Hinds, Joseph J Shatzel, Paul Kievit, Terry K Morgan, Samuel Tassi Yunga, Thuy T M Ngo, Joseph E Aslan, Michael Wallisch, Christina U Lorentz, Erik I Tucker, David Gailani, Jonathan R Lindner, Cristina Puy, Owen J T McCarty
BACKGROUND: Hyperlipidemia is associated with chronic inflammation and thromboinflammation. This is an underlying cause of several cardiovascular diseases, including atherosclerosis. In diseased blood vessels, rampant thrombin generation results in the initiation of the coagulation cascade, activation of platelets, and endothelial cell dysfunction. Coagulation factor (F) XI represents a promising therapeutic target to reduce thromboinflammation, as it is uniquely positioned at an intersection between inflammation and thrombin generation...
January 2024: Research and Practice in Thrombosis and Haemostasis