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Circular RNA in HCC

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https://www.readbyqxmd.com/read/30546088/exosome-circrna-secreted-from-adipocytes-promotes-the-growth-of-hepatocellular-carcinoma-by-targeting-deubiquitination-related-usp7
#1
Haiyang Zhang, Ting Deng, Shaohua Ge, Ying Liu, Ming Bai, Kegan Zhu, Qian Fan, Jialu Li, Tao Ning, Fei Tian, Hongli Li, Wu Sun, Guoguang Ying, Yi Ba
Hepatocellular carcinoma (HCC), the major form of liver cancer, has shown increasing incidence and poor prognosis. Adipose tissue is known to function in energy storage and metabolism regulation by the secretion of adipokines. Circular RNAs (circRNAs), a novel type of noncoding RNA, have recently been recognized as key factors in tumor development, but the role of exosome circRNAs derived from adipose tissues has not been defined yet. Here, adipose-secreted circRNAs were found to regulate deubiquitination in HCC, thus facilitating cell growth...
December 13, 2018: Oncogene
https://www.readbyqxmd.com/read/30537115/circular-rna-profiling-identifies-circadamts13-as-a-mir-484-sponge-which-suppresses-cell-proliferation-in-hepatocellular-carcinoma
#2
Liman Qiu, Yanbing Huang, Zhenli Li, Xiuqing Dong, Geng Chen, Haipo Xu, Yongyi Zeng, Zhixiong Cai, Xiaolong Liu, Jingfeng Liu
Circular RNAs (circRNAs) can participate in various biological processes, including tumorigenesis, through their microRNA response elements (MREs). Alterations in circRNA profiles during hepatocellular carcinoma (HCC) progression and the clinical significance thereof remain unclear. Here, we present extensive analysis of circRNA profiles in tumor and matched peritumor tissues collected from 10 HCC patients, conducted to identify circRNAs related to HCC progression. A total of 42 dysregulated circRNAs (38 down-regulated and 4 up-regulated) were identified in HCC tumor tissues when compared with matched peritumor tissues, revealing the heterogeneity of circRNA profiles in HCC...
December 8, 2018: Molecular Oncology
https://www.readbyqxmd.com/read/30453307/circular-rna-hsa_circ_0091579-serves-as-a-diagnostic-and-prognostic-marker-for-hepatocellular-carcinoma
#3
Chenxing Zhang, Chenyue Zhang, Jiamao Lin, Haiyong Wang
BACKGROUND/AIMS: An increasing number of studies have suggested that circular RNAs (circRNAs) have vital roles in carcinogenesis and tumor progression. However, the function of circRNAs in hepatocellular carcinoma (HCC) remains poorly characterized. METHODS: We investigated the levels of circRNAs in patients with HCC to identify potential diagnostic biomarkers. We examined circRNA expression profiles in liver tumors and paired non-cancerous liver tissues from three HCC patients with cancer thrombus using a circRNA microarray...
2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/30361504/circrna_104075-stimulates-yap-dependent-tumorigenesis-through-the-regulation-of-hnf4a-and-may-serve-as-a-diagnostic-marker-in-hepatocellular-carcinoma
#4
Xiao Zhang, Yanfeng Xu, Zijun Qian, Weisheng Zheng, Qi Wu, Yan Chen, Guoqing Zhu, Ya Liu, Zhixuan Bian, Wen Xu, Yue Zhang, Fenyong Sun, Qiuhui Pan, Jiayi Wang, Lutao Du, Yongchun Yu
Some types of circular RNA (circRNA) are aberrantly expressed in human diseases including hepatocellular carcinoma (HCC). However, its regulation mechanism and diagnostic roles are largely unknown. Here, we identified that circRNA_104075 (circ_104075) was highly expressed in HCC tissues, cell lines and serum. Mechanistically, HNF4a bound to the -1409 to -1401 region of the circ_104075 promoter to stimulate the expression of circ_104075. Moreover, circ_104075 acted as a ceRNA to upregulate YAP expression by absorbing miR-582-3p...
October 25, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/30317540/the-competing-endogenous-circular-rna-adamts14-suppressed-hepatocellular-carcinoma-progression-through-regulating-microrna-572-regulator-of-calcineurin-1
#5
Changlong Song, Dianqiu Li, Hongyu Liu, Hongyan Sun, Zhen Liu, Lirong Zhang, Yu Hu
Emerging evidence have discovered that circular RNAs (circRNAs) may serve as diagnostic or tumor promising biomarkers. This study aimed to investigate how circular RNA ADAMTS14 (circADAMTS14) regulates microRNA-572/ regulator of calcineurin 1(miR-572/ RCAN1) in hepatocellular carcinoma (HCC). The expression profiles of circRNA/microRNA (mRNA) between HCC tissues and paired adjacent tissues were analyzed via microarray analysis. The expressions of circADAMTS14, miR-572, and RCAN1 were measured by real-time polymerase chain reaction (PCR)...
March 2019: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/30302825/hsa_circ_101280-promotes-hepatocellular-carcinoma-by-regulating-mir-375-jak2
#6
Shuang Cao, Guohua Wang, Jia Wang, Cheng Li, Le Zhang
In this study, we sought to predict the effects of a certain circular RNA (circRNA), hsa_circ_101280 (also known as hsa_circ_0100929 and hsa_circ_SLAIN1), on hepatocellular carcinoma (HCC) cells and to determine the potential mechanism. After screening differentially expressed circRNAs in HCC tissues through GEO data analysis, hsa_circ_101280 was found to be highly expressed, and its high expression was verified in HCC cell lines with qRT-PCR along with the low expression of its downstream miRNA miR-375. Colony formation and flow cytometry assays showed that both hsa_circ_101280 silencing and miR-375 overexpression restrained proliferation and promoted apoptosis in HCC cells...
October 9, 2018: Immunology and Cell Biology
https://www.readbyqxmd.com/read/30301171/clinical-implications-of-hepatitis-b-virus-rna-and-covalently-closed-circular-dna-in-monitoring-patients-with-chronic-hepatitis-b-today-with-a-gaze-into-the-future-the-field-is-unprepared-for-a-sterilizing-cure
#7
REVIEW
Anastasiya Kostyusheva, Dmitry Kostyushev, Sergey Brezgin, Elena Volchkova, Vladimir Chulanov
. Chronic hepatitis B virus (HBV) infection has long remained a critical global health issue. Covalently closed circular DNA (cccDNA) is a persistent form of the HBV genome that maintains HBV chronicity. Decades of extensive research resulted in the two therapeutic options currently available: nucleot(s)ide analogs and interferon (IFN) therapy. A plethora of reliable markers to monitor HBV patients has been established, including the recently discovered encapsidated pregenomic RNA in serum, which can be used to determine treatment end-points and to predict the susceptibility of patients to IFN...
October 5, 2018: Genes
https://www.readbyqxmd.com/read/30265210/circular-rna-101368-mir-200a-axis-modulates-the-migration-of-hepatocellular-carcinoma-through-hmgb1-rage-signaling
#8
Shaling Li, Huimin Gu, Yan Huang, Qian Peng, Rongrong Zhou, Panpan Yi, Ruochan Chen, Zebing Huang, Xingwang Hu, Yun Huang, Daolin Tang
Hepatocellular carcinoma (HCC), one of the most common type of cancers, is highly refractory to most systemic therapies. Understanding the genomic dysregulations, in particularly non-coding RNA (ncRNA) dysregulations, in HCC may provide novel strategies to HCC treatment. In our previous study, we demonstrated the key role of miR-200a-mediated HMGB1/RAGE signaling in HCC carcinogenesis. In the present study, we identified circular RNA (circRNA)-miRNA pair that might modulate the migration of HCC cell lines based on previously reported GEO database (GSE78520 and GSE43445) and investigated the function and molecular mechanism...
2018: Cell Cycle
https://www.readbyqxmd.com/read/30262738/viral-biomarkers-in-chronic-hbeag-negative-hbv-infection
#9
REVIEW
Emilia Hadziyannis, Andreas Laras
Viral biomarkers are important tools for monitoring chronic hepatitis B virus (HBV) hepatitis B early antigen (HBeAg) negative infection, both in its natural course as well as during and after treatment. The biomarkers consist of antibodies against viral epitopes, viral proteins, and molecular surrogate markers of the quantity and transcriptional activity of the stable episomal HBV covalently closed circular DNA (cccDNA) which is located in the nuclei of the infected hepatocytes. HBV deoxyribonucleic acid (DNA) or else viral load measurement in plasma or serum is a marker of HBV replication of major clinical importance...
September 27, 2018: Genes
https://www.readbyqxmd.com/read/30224380/non-coding-rna-in-drug-resistance-of-hepatocellular-carcinoma
#10
REVIEW
Bisha Ding, Weiyang Lou, Liang Xu, Weimin Fan
Hepatocellular carcinoma (HCC) has been one of the most highly lethal cancers. The acquisition of drug resistance accounts for the majority of poor effects of chemotherapy in HCC. Non-coding RNAs (ncRNAs) including miRNAs, long ncRNAs (lncRNAs), and circular RNA (circRNA) have been well-documented to participate in cancer occurrence and progression. Recently, multiple studies have highlighted the key roles of ncRNAs in chemoresistance of HCC. In addition, accumulating evidence has demonstrated that they can serve as biomarkers in diagnosis, treatment, and prognosis of HCC...
October 31, 2018: Bioscience Reports
https://www.readbyqxmd.com/read/30191143/prospect-of-circular-rna-in-hepatocellular-carcinoma-a-novel-potential-biomarker-and-therapeutic-target
#11
REVIEW
Renzhi Yao, Haifan Zou, Weijia Liao
CircRNA, a kind of tissue specific and covalently closed circular non-coding RNA is very abundant in eukaryocyte. Generally, circRNA is generated by back-splicing of protein-coding genes' pre-mRNA. Hepatocellular carcinoma (HCC) is one of the most common malignant tumors in the world. Due to the characteristics of poor prognosis and high recurrence, the pathogenesis of HCC is highly concerned by researchers worldwide. Recent studies demonstrated that numerous circRNAs were differentially expressed in HCC tissues and normal liver tissues, which is closely related with the development and prognosis of HCC...
2018: Frontiers in Oncology
https://www.readbyqxmd.com/read/30086881/overexpression-of-circular-rna-circ_001569-indicates-poor-prognosis-in-hepatocellular-carcinoma-and-promotes-cell-growth-and-metastasis-by-sponging-mir-411-5p-and-mir-432-5p
#12
Hongyuan Liu, Li Xue, Changyue Song, Fang Liu, Tingjun Jiang, Xiuhua Yang
Emerging evidence indicated that abnormally expressed circular RNAs (circRNAs) are critically involved in tumorigenesis and development of several cancers. However, the study relevant to the relationship between circRNAs and hepatocellular carcinoma (HCC) is rare. In this study, the expression of circ_001569 in HCC tissue specimens and cells were determined by qRT-PCR. The clinical relevance of circ_001569 was also analyzed. In addition, loss-of-function and gain-of-function assays were conducted to explore the biological functions of circ_001569...
September 18, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/30072625/circular-rnas-characteristics-function-and-clinical-significance-in-hepatocellular-carcinoma
#13
REVIEW
Man Wang, Fei Yu, Peifeng Li
Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related deaths worldwide. HCC patients are commonly diagnosed at an advanced stage, for which highly effective therapies are limited. Moreover, the five-year survival rate of HCC patients remains poor due to high frequency of tumor metastasis and recurrence. These challenges give rise to the emergent need to discover promising biomarkers for HCC diagnosis and identify novel targets for HCC therapy. Circular RNAs (circRNAs), a class of long-overlook non-coding RNA, have been revealed as multi-functional RNAs in recent years...
August 2, 2018: Cancers
https://www.readbyqxmd.com/read/30053867/circfblim1-act-as-a-cerna-to-promote-hepatocellular-cancer-progression-by-sponging-mir-346
#14
Ning Bai, Eming Peng, Xingsheng Qiu, Ning Lyu, Zhejia Zhang, Yiming Tao, Xinying Li, Zhiming Wang
BACKGROUD: Accumulating evidences indicate that circular RNAs (circRNAs), a class of non-coding RNAs, play important roles in tumorigenesis. However, the function of circRNAs in hepatocellular cancer (HCC) is largely unknown. METHODS: We performed circRNA microarrays to identify circRNAs that are aberrantly expressed in HCC tissues. Expression levels of a significantly upregulated circRNA, circFBLIM1, was detected by quantitative real-time PCR (qRT-PCR) in HCC cell lines and tissues...
July 27, 2018: Journal of Experimental & Clinical Cancer Research: CR
https://www.readbyqxmd.com/read/29923236/circular-rna-hsa_circ_0016788-regulates-hepatocellular-carcinoma-tumorigenesis-through-mir-486-cdk4-pathway
#15
Zheng Guan, Jing Tan, Wei Gao, Xin Li, Yuandong Yang, Xiaogang Li, Yingchao Li, Qiang Wang
Recent studies have revealed that circular RNAs (circRNAs) play important roles in the tumorigenesis of human cancer, including hepatocellular carcinoma (HCC). In present study, we screen the circular RNA expression profiles in HCC tissue and investigate the molecular roles on HCC tumorigenesis. Human circRNA microarray analysis showed there were total 1,245 differently expressed circular RNAs, including 756 up-regulated circRNAs and 489 down-regulated circRNAs, in three pairs of HCC tissue and adjacent normal tissue...
January 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29916745/effects-of-hsa_circrbm23-on-hepatocellular-carcinoma-cell-viability-and-migration-as-produced-by-regulating-mir-138-expression
#16
Baoyong Wang, Hongwei Chen, Chunfen Zhang, Tian Yang, Qiaofei Zhao, Yifan Yan, Yu Zhang, Feng Xu
Primary hepatocellular carcinoma (HCC) is one of the most common malignant tumors. At present, the molecular mechanism of HCC remains unclear. A recent circular RNA (circRNA) profiling study showed that circRBM23 expression was upregulated in HCC tissues. Therefore, in this study, the impact of circRBM23 during the progression of HCC was evaluated. The expression levels of circRBM23 and miR-138 in HCC tissues and HCC cell lines were determined by RT-PCR and the results indicated that circRBM23 expression was increased in the HCC tissues and HCC cell lines, whereas miR-138 expression was decreased...
June 2018: Cancer Biotherapy & Radiopharmaceuticals
https://www.readbyqxmd.com/read/29914004/screening-and-bioinformatics-analysis-of-circular-rna-expression-profiles-in-hepatitis-b-related-hepatocellular-carcinoma
#17
Shanshan Wang, Shichang Cui, Wenming Zhao, Zhiling Qian, Hui Liu, Yuhan Chen, Fudong Lv, Hui-Guo Ding
BACKGROUND: Circular RNAs (circRNAs) play an important role in pathogenesis and development of hepatocellular carcinoma (HCC). However, circRNA expression profiles in hepatitis B Virus (HBV)-related HCC remain to be studied. METHODS: Total 13 HBV-related HCC patients were enrolled for study. Three HCC and 3 paired adjacent non-tumorous (NT) tissues from 3 patients were performed for microarray. Ten pairs of HCC tissues were used to verify the identified up-regulated and down-regulated circRNAs obtained from the microarray data by quantitative real-time reverse transcription PCR (qRT-PCR)...
2018: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/29849467/screening-differential-circular-rna-expression-profiles-reveal-that-hsa_circ_0128298-is-a-biomarker-in-the-diagnosis-and-prognosis-of-hepatocellular-carcinoma
#18
Dawei Chen, Chenyue Zhang, Jiamao Lin, Xinyu Song, Haiyong Wang
Aim: The aim of this study was to analyze the diagnostic and prognostic values of the circular RNA (circRNA) hsa_circ_0128298 in hepatocellular carcinoma (HCC). Patients and methods: The global circRNA expression was measured using circRNA microarray using three pairs of cancer and noncancerous tissues from HCC patients. The microarray analysis revealed that two circRNAs were differentially expressed in the three pairs of cancerous and noncancerous tissues. The higher levels of two representative circRNAs, such as hsa_circ_0128298 and hsa_circ_0091582, were further confirmed by real-time polymerase chain reaction...
2018: Cancer Management and Research
https://www.readbyqxmd.com/read/29844124/twist1-regulates-vimentin-through-cul2-circular-rna-to-promote-emt-in-hepatocellular-carcinoma
#19
Jing Meng, Shuang Chen, Jing-Xia Han, Baoxin Qian, Xiao-Rui Wang, Wei-Long Zhong, Yuan Qin, Heng Zhang, Wan-Feng Gao, Yue-Yang Lei, Wei Yang, Lan Yang, Chao Zhang, Hui-Juan Liu, Yan-Rong Liu, Hong-Gang Zhou, Tao Sun, Cheng Yang
Twist is a critical epithelial-mesenchymal transition (EMT)-inducing transcription factor that increases expression of vimentin. How Twist1 regulates this expression remains unclear. Here, we report that Twist1 regulates Cullin2 (Cul2) circular RNA to increase expression of vimentin in EMT. Twist1 bound the Cul2 promoter to activate its transcription and to selectively promote expression of Cul2 circular RNA (circ-10720), but not mRNA. circ-10720 positively correlated with Twist1, tumor malignance, and poor prognosis in hepatocellular carcinoma (HCC)...
August 1, 2018: Cancer Research
https://www.readbyqxmd.com/read/29785842/circular-rna-0068669-as-a-new-biomarker-for-hepatocellular-carcinoma-metastasis
#20
Ting Yao, Qingqing Chen, Zhouwei Shao, Zhihua Song, Liyun Fu, Bingxiu Xiao
BACKGROUND: Circular RNAs (circRNAs) play important roles in disease occurrence. However, the roles of circRNAs in the diagnosis of hepatocellular carcinoma (HCC) are largely unknown. The aim of this study is to investigate the clinical diagnostic values of hsa_circ_0068669 (Alias: hsa_circ_103561), one of the representative HCC-associated circRNAs. METHODS: Hsa_circ_0068669 expression levels in HCC tissues, HCC cell lines, and chronic hepatitis tissues were detected by real-time quantitative reverse transcription-polymerase chain reaction...
October 2018: Journal of Clinical Laboratory Analysis
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