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Dongliang Wang, Huijie Hou, Jingping Hu, Jikun Xu, Long Huang, Shaogang Hu, Sha Liang, Keke Xiao, Bingchuan Liu, Jiakuan Yang
Bio-electro-Fenton (BEF) system holds great potential for sustainable degradation of refractory organics. Activated carbon (AC) air cathode was modified by co-pyrolyzing of AC with glucose and doping with nano-zero-valent iron (denoted as nZVI@MAC) in order to promote two-electron oxygen reduction reaction (2e- ORR) for enhanced oxidizing performance. Single chamber microbial fuel cells (SCMFCs) with nZVI@MAC cathode was examined to degrade landfill leachate. It was revealed that nZVI@MAC cathode SCMFC showed higher degradation efficiency towards landfill leachate...
October 5, 2018: Chemosphere
Chong-Jin Zhong, Miao-Miao Chen, Ming Lu, Jian-Hua Ding, Ren-Hong Du, Gang Hu
ATP-sensitive potassium (K-ATP) channels, coupling cell metabolism to cell membrane potential, are involved in brain diseases including stroke. Emerging evidence shows that astrocytes play important roles in the pathophysiology of cerebral ischemia. Kir6.1, a pore-forming subunit of K-ATP channel, is prominently expressed in astrocytes and participates in regulating its function. However, the exact role of astrocytic Kir6.1-containg K-ATP channel (Kir6.1/K-ATP) in ischemic stroke remains unclear. Here, we found that astrocytic Kir6...
October 10, 2018: Experimental Neurology
Qianru Li, Yuexi Yang, Fei Hu, Yanxue Cai, Xiaoyun Liu, Xiaowei He
To ensure food safety and avoid infections by Escherichia coli O157:H7 (E. coli O157:H7), we developed a novel fluorescent microsphere (FM)-based immunochromatography assay (FM-ICA). FMs were conjugated to anti-E. coli O157:H7 monoclonal antibody (MAb) as an ICA probe, Immunomagnetic beads (IM-beads) were prepared by conjugating functionalized magnetic microspheres with the antibody for enrichment and separation of pathogenic bacteria from complex food matrices. Under selected conditions, a standard curve of FM-ICA measurement of E...
October 10, 2018: Analytical Biochemistry
Huimin Hu, Changyuan Wang, Yue Jin, Qiang Meng, Qi Liu, Zhihao Liu, Kexin Liu, Xiaoyu Liu, Huijun Sun
Hyperhomocysteinemia (HHCY) has been recognized as an independent risk factor for atherosclerosis and plays a vital role in the development of atherosclerosis. Catalpol, an iridoid glucoside extracted from the root of Rehmannia glutinosa, can produce anti-inflammatory, anti-oxidant, anti-tumor, and dopaminergic neurons protecting effects. This study aimed to determine the protecting effects of catalpol against homocysteine (HCY)-induced injuries in human aortic endothelial cells (HAECs) and uncover the underlying mechanisms: 1...
October 12, 2018: Inflammation
Ke Ma, Yangwei Fan, Yuan Hu
BACKGROUND: In the past 2 decades, metastasis-associated gene 1 (MTA1) has attracted attention for its close association with cancer progression and its roles in chromatin remodeling processes, making it a central gene in cancer. The present meta-analysis was performed to assess MTA1 expression in solid tumors. MATERIALS AND METHODS: This analysis identified studies that evaluated the relationship between MTA1 expression and clinical characteristics or prognosis of patients with solid tumors via the PubMed, Cochrane Library, and Embase electronic databases...
October 2018: Medicine (Baltimore)
Jing Zheng, Yonggang Sha, Logan Roof, Oded Foreman, John Lazarchick, Jagadish Kummetha Venkta, Cleopatra Kozlowski, Cristina Gasparetto, Nelson Chao, Allen Ebens, Jianda Hu, Yubin Kang
Multiple myeloma remains an incurable disease, and continued efforts are required to develop novel agents and novel drug combinations with more effective anti-myeloma activity. Here, we show that the pan-PIM kinase inhibitors SGI1776 and CX6258 exhibit significant anti-myeloma activity and that combining a pan-PIM kinase inhibitor with the immunomodulatory agent lenalidomide in an in vivo myeloma xenograft mouse model resulted in synergistic myeloma cell killing without additional hematologic or hepatic toxicities...
October 9, 2018: Cancer Letters
Chunyu Yuan, Congsong Sun, Yexiang Sun, Qincheng Wang, Biao Wang, Chunhua Wang, Yizhong Tang, Delin Hu, Xingzhao Li, Junhui Song
OBJECTIVE: To explore the mechanism of hypertonic salt solution (HS) alleviates lung injury of rats at the early stage of severe scald. METHODS: Thirty-two female Sprague-Dawley (SD) rats were randomly assigned to sham group, lactated Ringer solution (LR) group, HS200 group (200 mmol/L HS group, 1 L 200 mmol/L HS contained 955 mL LR and 45 mL 10% NaCl) and HS400 group (400 mmol/L HS group, 1 L 400 mmol/L HS contained 846 mL LR and 154 mL 10% NaCl), with 8 rats in each group...
September 2018: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
Yan Li, Julei Zhang, Qin Zhou, Hongtao Wang, Songtao Xie, Xuekang Yang, Peng Ji, Wanfu Zhang, Ting He, Yang Liu, Kejia Wang, Xiaoqiang Li, Jihong Shi, Dahai Hu
Hypertrophic scar (HS) is a fibro-proliferative disease after serious burns, the underlying mechanism remains unknown. The study was performed to clarify the effect of high glucose (HG) on HS. The expression of Col1, Col3 and α-SMA were up-regulated in HS derived fibroblasts (HSFs) exposed to HG (20mM, 30mM), and HG activated the phosphorylated protein expression of IGF/Akt/mTOR signaling pathway in HSFs. Dpp4, a marker targeted the treatment of diabetes mellitus, was overexpressed in HG-induced HSFs. Linagliptin, a Dpp4 inhibitor, played the anti-fibrosis role in HSFs exposed to HG, the levels of Col1, Col3 and α-SMA were significantly down-regulated, the cell proliferation and migration was also inhibited...
October 11, 2018: Experimental Dermatology
Juan Kong, Li Han, Han Su, Yihan Hu, Xueshi Huang, Yan Lou
BACKGROUND/AIMS: Nephropathy related with renin can be alleviated with ACE-inhibitors or AT1R blockers, whereas they might be ineffective after long-term administration because of a feedback production of enhanced renin. Therefore, it is urgent to develop a new category of anti-nephropathy medicine directly targeting renin. Riligustilide (C20), originally isolated from the Chinese herb Ligusticumporteri, a rhizome, was confirmed effective against many diseases. METHODS: The therapeutic effect of C20 on renal injury and its underlying mechanism were investigated in three different nephrotic models, which were spontaneously hypertension rats (SHR) model, diabetic nephropathy in BTBR ob/ob mice model and 5/6-nephrectomized (5/6NX) rats model...
October 11, 2018: Cellular Physiology and Biochemistry
Wei Li, Yun Li, Ya-Zhou Hu, Xu-Bing Mo, Guo-Huan Xu, Li-Wei Xie, An-Xing Li
Streptococcus agalactiae is the major etiological agent of streptococcosis, which is responsible for huge economic losses in fishery, particularly in tilapia (Oreochromis niloticus) aquaculture. A research priority to control streptococcosis is to develop vaccines, so we sought to figure out the immunogenic proteins of S. agalactiae and screen the vaccine candidates for streptococcosis in the present study. Immunoproteomics, a technique involving two-dimensional gel electrophoresis (2-DE) followed by immunoblotting and mass spectrometry (MS), was employed to investigate the immunogenic proteins of S...
October 8, 2018: Fish & Shellfish Immunology
Yuzhu Hu, Cong Wu, Changhui Zhu, Qingyu Fu, Jiajun Guo, Lihong Deng, Yihong He, Daoke Yang, Yongzhong Cheng, Xiang Gao
Colorectal cancer (CRC) exhibited high incidence rate worldwide and the advanced CRC had a poor prognosis. Thereupon, seeking efficient treatment for CRC is critical. Apatinib is a novel vascular epithelial growth factor receptor (VEGFR) inhibitor with inspiring therapeutic effect in some malignant cancers. In our study, doxorubicin was mixed in fibrin gel and apatinib was encapsulated with self-synthesized liposome. The results showed liposomal apatinib (Lipo-Apatinib) could enhance the intracellular uptake of doxorubicin in vitro...
October 8, 2018: International Journal of Pharmaceutics
Xiaoli Hu, Hailing Liu, Miaomiao Ye, Xueqiong Zhu
Background: Several epidemiological researches have indicated that microvessel density (MVD), reflecting angiogenesis, was a negatively prognostic factor of cervical cancer. However, the results were inconsistent. Therefore, we performed a meta-analysis to evaluate the association between microvessel density and the survival probability of patients with cervical cancer. Method: There was a comprehensive search of the PubMed, EMBASE and Cochrane databases up to August 31, 2017...
2018: Cancer Cell International
Kui Zhang, Gang Fu, Guangzhao Pan, Chongyang Li, Li Shen, Renjian Hu, Shunqin Zhu, Yibiao Chen, Hongjuan Cui
Glioma is the most common and malignant form of primary brain tumour, and is characterised by high proliferation and extensive invasion and neurological destruction. Demethylzeylasteral (T-96), which is extracted from Tripterygium wilfordii, is considered to have immunosuppressive, anti-inflammatory and anti-angiogenic effects. Here, the anti-tumour effect of T-96 on glioma was evaluated. Our results demonstrated that T-96 significantly inhibited glioma cell growth and induced cell cycle arrest in G1 phase but did not induce apoptosis...
October 10, 2018: Cell Death & Disease
Takeshi Hisamatsu, Michael McGuire, Sherry Y Wu, Rajesha Rupaimoole, Sunila Pradeep, Emine Bayraktar, Kyunghee Noh, Wei Hu, Jean M Hansen, Yasmin Lyons, Kshipra M Gharpure, Archana S Nagaraja, Lingegowda S Mangala, Takashi Mitamura, Cristian Rodriguez-Aguayo, Young Gyu Eun, Johnathon Rose, Geoffrey Bartholomeusz, Cristina Ivan, Ju-Seog Lee, Koji Matsuo, Michael Frumovitz, Kwong K Wong, Gabriel Lopez-Berestein, Anil K Sood
For mucinous ovarian cancer (MOC), standard platinum based therapy is largely ineffective. We sought to identify possible mechanisms of oxaliplatin resistance of MOC and develop strategies to overcome this resistance. A kinome-based small interfering RNA (siRNA) library screen was carried out using human MOC cells to identify novel targets to enhance the efficacy of chemotherapy. In vitro and in vivo validations of antitumor effects were performed using mouse MOC models. Specifically, the role of PRKRA/PACT in oxaliplatin resistance was interrogated...
October 10, 2018: Molecular Cancer Therapeutics
Rong-Sheng Qin, Zhen-Hua Zhang, Neng-Ping Zhu, Fei Chen, Qian Guo, Hao-Wen Hu, Shao-Zhi Fu, Shan-Shan Liu, Yue Chen, Juan Fan, Yun-Wei Han
BACKGROUND: Conventional chemotherapy is commonly used to treat non-small cell lung cancer (NSCLC) however it increases therapeutic resistance. In contrast, metronomic chemotherapy (MET) is based on frequent drug administration at lower doses, resulting in inhibition of neovascularization and induction of tumor dormancy. This study aims to evaluate the inhibitory effects, adverse events, and potential mechanisms of MET Vinorelbine (NVB) combined with an angiogenesis inhibitor (Endostar)...
October 11, 2018: BMC Cancer
Ying Gao, Cheng Yu, Shulan Pi, Ling Mao, Bo Hu
Atherosclerosis is a chronic and progressive disease of the arterial walls and a leading cause of non-cardioembolic ischemic stroke. P2Y12 is a well-recognized receptor that is expressed on platelets and is a target of thienopyridine-type antiplatelet drugs. In the last few decades, P2Y12 receptor inhibitors, such as clopidogrel, have been applied for the secondary prevention of non-cardioembolic ischemic stroke. Recent clinical studies have suggested that these P2Y12 receptor inhibitors may be more effective than other antiplatelet drugs in patients with ischemic stroke/transient ischemic attack of atherosclerotic origin...
October 9, 2018: Cellular and Molecular Life Sciences: CMLS
Shuye Lin, Xiaoyue Wang, Yuanming Pan, Rongmeng Tian, Bonan Lin, Guo-Sheng Jiang, Keqiang Chen, Yu-Qi He, Lulu Zhang, Wanli Zhai, Peng Jin, Lang Yang, Guoqiang Li, Yun Wu, Jiang Hu, Wanghua Gong, Zhijie Chang, Jian-Qiu Sheng, Youyong Lu, Ji-Ming Wang, Jiaqiang Huang
PURPOSE: Metallothionein 2A (MT2A) suppresses the progression of human gastric cancer (GC) potentially through an "MT2A-NF-κB pathway" with unclear mechanisms. This study explored the role of a transcription factor, myeloid zinc-finger 1 (MZF1), in MT2A-NF-κB pathway and its clinical significance in GC. EXPERIMENTAL DESIGN: MZF1 expression and function in GC were investigated in vitro and in vivo. The relationship between MZF1 and MT2A was determined by gain- and loss-of-function assays in GC cells and an immortalized gastric cell line GES-1...
October 9, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
Yong Li, Jialin Hu, Hongping Song, Tao Wu
Chronic myeloid leukemia (CML) responds well to BCR-ABL tyrosine kinase inhibitors (TKI), such as imatinib and dasatinib. However, these inhibitors have been less effective as single agents in the blast phase-CML. In this work, we show that anisomycin, a clinically available drug, targets CML cells at all stages of development and enhances BCR-ABL TKIs' efficacy. Anisomycin at nanomolar concentration inhibits proliferation and induces apoptosis in a panel of CML cell lines in a dose-dependent manner. It induces apoptosis CD34 stem/progenitor cells isolated from patients with blast phase CML...
October 6, 2018: Biochemical and Biophysical Research Communications
Zili Xie, Hongzhen Hu
Although acute itch has a protective role by removing irritants to avoid further damage, chronic itch is debilitating, significantly impacting quality of life. Over the past two decades, a considerable amount of stimulating research has been carried out to delineate mechanisms of itch at the molecular, cellular, and circuit levels. There is growing evidence that transient receptor potential (TRP) channels play important roles in itch signaling. The purpose of this review is to summarize our current knowledge about the role of TRP channels in the generation of itch under both physiological and pathological conditions, thereby identifying them as potential drug targets for effective anti-itch therapies...
October 6, 2018: Pharmaceuticals
Yi-Jung Ho, Feng-Cheng Liu, Chia-Tsui Yeh, Chuen Mi Yang, Chang-Chi Lin, Te-Yu Lin, Po-Shiuan Hsieh, Ming-Kuan Hu, Zhiyuan Gong, Jeng-Wei Lu
The chikungunya virus (CHIKV) is a mosquito-borne virus that belongs to the genus Alphavirus, family Togaviridae. It is the cause of chikungunya fever in humans, which presents a serious global threat due to its high rate of contagion. The clinical symptoms of CHIKV include fever and persistent, severe arthritis. Micafungin has broad-spectrum fungicidal activity against Candida spp. is a promising echinocandin that was recently approved by the U.S. Food and Drug Administration (FDA) and has demonstrated activity against Candida and Aspergillus...
October 6, 2018: Antiviral Research
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