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Yingping Cao, Conglian Wu, Yanfang Song, Zhen Lin, Yanli Kang, Pingxia Lu, Chenqing Zhang, Qinghua Huang, Taisen Hao, Xianjin Zhu, Jianda Hu
Elevated Cyr61 levels have been reported in various malignancies. Elevation of Cyr61 protein levels contributes to the proliferation, metastasis, and chemotherapy resistance of malignant cells. Previously, it was discovered that Cyr61 is elevated in both the plasma and the bone marrow supernatants of patients with acute lymphoblastic leukemia (ALL), promoting ALL cell survival. However, the role of Cyr61 in the chemotherapeutic resistance of ALL cells remains unknown. The aim of the current study was to investigate the role of Cyr61 in regulating ALL cell chemosensitivity to Ara‑C...
December 6, 2018: International Journal of Molecular Medicine
Hua Jiang, Jingjing Fan, Lin Cheng, Pan Hu, Renbin Liu
Background: Most breast cancers are estrogen dependent and were sensitive to endocrine therapy, and genistein (GEN) shows strong affinity with human oestrogen receptor beta (ERβ). Purpose: The present study aimed to investigate the anticancer activity of GEN in breast cancer cell lines that constitutively expressing ERβ1 in vitro and in vivo. Methods: MCF-7/ERβ1 and MDA-MB-231/ERβ1 cell sub-lines were established through lentiviral infection...
2018: OncoTargets and Therapy
Qian Chen, Chao Wang, Xudong Zhang, Guojun Chen, Quanyin Hu, Hongjun Li, Jinqiang Wang, Di Wen, Yuqi Zhang, Yifei Lu, Guang Yang, Chen Jiang, Jun Wang, Gianpietro Dotti, Zhen Gu
Cancer recurrence after surgical resection remains a significant cause of treatment failure. Here, we have developed an in situ formed immunotherapeutic bioresponsive gel that controls both local tumour recurrence after surgery and development of distant tumours. Briefly, calcium carbonate nanoparticles pre-loaded with the anti-CD47 antibody are encapsulated in the fibrin gel and scavenge H+ in the surgical wound, allowing polarization of tumour-associated macrophages to the M1-like phenotype. The released anti-CD47 antibody blocks the 'don't eat me' signal in cancer cells, thereby increasing phagocytosis of cancer cells by macrophages...
December 10, 2018: Nature Nanotechnology
Gianni Belcaro, Shu Hu, Jeff Strong, Beatrice Feragalli, Giulia Vinciguerra, Marisa Cacchio, Maria Rosaria Cesarone
BACKGROUND: This registry study evaluated the effects of G3 Sports supplement drink (G3) on performance and endurance in triathlon in amateur athletes in a period of 2 weeks of training. G3 is composed of a proprietary fruit juice blend high in carotenoid compounds as well as 100 mg of standardized French oak (Quercus robur) wood extract, Robuvit®, per 50 mL bottle. The antioxidant and anti-inflammatory actions of the compounds in G3 may improve training efficiency (decreasing post-triathlon muscular pain, cramps and improve recovery time) and decrease post-training plasma free radicals (PFR)...
December 2018: Minerva Medica
Cheng Hu, Weiping Jia
Diabetes has become one of the largest global health and economic burdens, with its increased prevalence and high complication ratio. Stable and satisfactory blood glucose control are vital to reduce diabetes-related complications. Therefore, continuous attempts have been made in antidiabetic drugs, treatment routes, and traditional Chinese medicine to achieve better disease control. New antidiabetic drugs and appropriate combinations of these drugs have increased diabetes control significantly. Besides, novel treatment routes including oral antidiabetic peptide delivery, nanocarrier delivery system, implantable drug delivery system are also pivotal for diabetes control, with its greater efficiency, increased bioavailability, decreased toxicity and reduced dosing frequency...
December 5, 2018: Advanced Drug Delivery Reviews
Ruslan Grishanin, Brian Vuillemenot, Pallavi Sharma, Annahita Keravala, Judith Greengard, Claire Gelfman, Mark Blumenkrantz, Matthew Lawrence, Wenzheng Hu, Szilárd Kiss, Mehdi Gasmi
Inhibition of vascular endothelial growth factor, a key contributor to the choroidal neovascularization associated with wet age-related macular degeneration, is the mode of action of several approved therapies, including aflibercept, which requires frequent intravitreal injections to provide clinical benefit. Lack of compliance with the dosing schedule may result in recurrence of active wet macular degeneration, leading to irreversible vision impairment. Gene therapy providing sustained anti-vascular endothelial growth factor levels in the retina following a single injection could drastically reduce the treatment burden and improve visual outcomes...
November 13, 2018: Molecular Therapy: the Journal of the American Society of Gene Therapy
Jingli Liu, Biao Xu, Tingmei Chen, Jie Chen, Jing Feng, Chenyu Xu, Lanhua Liu, Yali Hu, Yi-Hua Zhou
BACKGROUND: We aimed to clarify whether presence of hepatitis B virus (HBV) markers in cord blood indicates exposure to or infection with HBV. METHODS: We prospectively recruited HBsAg-positive pregnant women and their neonates 2012 through 2015. All neonates received postnatal immunoprophylaxis. The infants were followed up at 7-14 months of age. RESULTS: Totally 329 HBsAg-positive pregnant women and 333 neonates were enrolled. No cord blood was anti-HBc IgM positive...
November 20, 2018: Digestive and Liver Disease
Yue Wang, Jing-Lin Wang, Hu-Cheng Ma, Zhen-Ting Tang, Hao-Ran Ding, Xiao-Lei Shi
In recent years, transplantation of mesenchymal stem cells (MSCs) has attracted much attention as a potential cell-based therapy for acute liver failure (ALF). As an inducible enzyme, heme oxygenase 1 (HO-1) has been reported to have cytoprotective, anti-apoptotic and immunoregulatory effects. Autophagy, a conserved catabolic process in cells, may be an important pathway for MSCs to treat ALF. In this study, we aimed to explore whether MSCs treat ALF by regulating autophagy and whether HO-1 was involved in the same pathway...
December 5, 2018: Biochemical and Biophysical Research Communications
Si Qin, Lifan Huang, Jiaojiao Gong, Shasha Shen, Juan Huang, Yao Tang, Hong Ren, Huaidong Hu
Oxidative stress (OS) is associated with aging and multiple diseases, yet the effects of curcumin in humans are not definite. We undertook a meta-analysis of the effects of curcumin on OS biomarkers. In January 2018, we searched PubMed, Books@Ovid, Journals@Ovid, EMBASE, MEDLINE(R), and Web of Science to identify randomized controlled trials conducted ≥4 weeks and investigating the effects of curcumin on OS biomarkers, including glutathione peroxidase (GPX) activity in red blood cells (RBC), serum malondialdehyde (MDA) concentrations, and superoxide dismutase (SOD) activity...
December 2018: Nutrition Research
Weihui Hu, Ray R Duan, Yiteng Xia, Qingping Xiong, Huaiyou Wang, Gallant Kar-Lun Chan, Siyue Liu, Tina T X Dong, Qiwei Qin, Karl W K Tsim
Resveratrol is a polyphenol commonly found in plants and food health products, such as grape and red wine; this was identified for its binding to vascular endothelial growth factor (VEGF) by using a HerboChips screening: the binding, therefore, resulted in alterations of VEGF binding to its receptor as well as pharmaceutical roles of VEGF in angiogenesis. Several lines of evidence gave support to the inhibitory activities of resveratrol in VEGF-triggered angiogenesis. In human umbilical vein endothelial cells (HUVECs), compared with VEGF-induced group, resveratrol, at a high concentration, suppressed VEGF-mediated endothelial cell proliferation, cell migration, cell invasion and tube formation by 80 ± 9...
December 10, 2018: Journal of Agricultural and Food Chemistry
Meinan Yu, Dunyan Su, Yuanyuan Yang, Lin Qin, Chuan Hu, Rui Liu, Yang Zhou, Chuanyao Yang, Xiaotong Yang, Guanlin Wang, Huile Gao
The blood brain tumor barrier (BTB) and blood-brain barrier (BBB) have always been the major barriers in the treatment of glioma. In this report, we proposed D-T7 peptide modified nanoparticles actively targeted glioma by overcoming the BBB and BTB to improve the anti-glioma efficacy. Glioma targeting experiment showed that the penetration effect of D-T7 peptide modified nanoparticles was 7.89-fold higher than that of unmodified nanoparticles. Furthermore, cediranib (CD) and paclitaxel (PTX) were used for the combination of the antiangiogenesis and chemotherapy of glioma...
December 10, 2018: ACS Applied Materials & Interfaces
Dina Schneider, Ying Xiong, Peirong Hu, Darong Wu, Weizao Chen, Tianlei Ying, Zhongyu Zhu, Dimiter S Dimitrov, Boro Dropulic, Rimas J Orentas
Acute myeloid leukemia (AML) remains a challenging pediatric and adult disease. Given the elevated expression of the CD33 antigen on leukemic blasts, therapeutic approaches to AML now feature the approved antibody drug conjugate (Mylotarg, GO) and investigational CART cell approaches incorporating CD33-binding domains derived from humanized scFvs. We designed a functional chimeric antigen receptor utilizing a human targeting sequence, derived from a heavy chain variable domain, termed CAR33VH. Lentiviral-based expression vectors which encoded CAR constructs incorporating the novel binding domain (CAR33VH), or the My96 scFv control binder (My96CAR) in frame with a CD8 hinge and transmembrane domain, a 4-1BB costimulatory domain and a CD3 zeta activation domain, were transduced into primary human CD4+ and CD8+ T cells, and CAR expression was confirmed by flow cytometry...
2018: Frontiers in Oncology
Rieneke van de Ven, Traci L Hilton, Hong-Ming Hu, Christopher J Dubay, Daniel Haley, Christopher Paustian, Sachin Puri, Walter J Urba, Brendan D Curti, Sandra Aung, Bernard A Fox
The immune system plays an essential role in eradicating cancer in concert with various treatment modalities. In the absence of autologous tumor material, no standardized method exists to assess T cell responses against the many antigens that may serve as cancer rejection antigens. Thus, development of methods to screen for therapy-induced anti-tumor responses is a high priority that could help tailor therapy. Here we tested whether a tumor-derived antigen source called DRibbles®, which contain a pool of defective ribosomal products (DRiPs), long-lived and short-lived proteins (SLiPs) and danger-associated molecular patterns (DAMPs), can be used to identify tumor-associated antigen (TAA)-specific responses in patients before or after immunotherapy treatment...
2018: Oncoimmunology
Xinrui Zheng, Ye Liao, Jiu Wang, Shijie Hu, Gudepalya Renukaiah Rudramurthy, Mallappa Kumara Swamy, Komdur Channabasavaraju Rohit, Yangang Wang
Microglial cells, upon hyperactivation, produce proinflammatory cytokines and other oxidative stress mediators causing neuroinflammation, which is associated with the progress of many neurodegenerative diseases. Suppressing the microglial activation has hence been used as an approach for treating such diseases. In this study, the antineuroinflammatory effect of simvastatin was examined in lipopolysaccharide (LPS)-activated rat C6 glioma cells. The cell proliferation and cytotoxic effect of LPS and simvastatin on C6 glioma cells was evaluated by (MTT) assay...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
Fenfen Gu, Chuling Hu, Qingming Xia, Chunai Gong, Shen Gao, Zhongjian Chen
Early diagnosis is primarily important for the therapeutic and prognostic outcomes of malignancies including prostate cancer (PCa). However, the visuality and veracity of ultrasound imaging for the diagnosis and prognostic prediction of PCa remains poor at present. In this study, we developed a new nanoultrasound contrast agent by modifying multi-walled carbon nanotubes (MWCNTs) with polyethylene glycol (PEG) and anti-PSMA aptamer. The result showed that the modified MWCNTs offered better visuality and veracity and were able to target PCa cells more effectively as compared with the traditional contrast agent...
2018: Journal of Nanoparticle Research: An Interdisciplinary Forum for Nanoscale Science and Technology
Jianming Hu, Kuancheng Liu, Jun Luo
Liver diseases that are caused by the hepatitis B virus (HBV) and hepatitis C virus (HCV), including cirrhosis and hepatocellular carcinoma (HCC), have become increasingly important in patients infected with the human immunodeficiency virus (HIV) as their life expectancy is getting longer with successful anti-HIV therapy. Due to their shared transmission routes, dual infection by HIV and HBV or HIV and HCV, and triple infection by all three viruses are fairly common and affect millions of people worldwide. Whereas the immunodeficiency caused by HIV enhances the likelihood of HBV and HCV persistence, hepatotoxicity associated with anti-HIV therapy can worsen the liver diseases associated with HBV or HCV persistence...
2019: Cancer Treatment and Research
Wen Chen, Shi-Qi Weng, Meng-Ge Lv, Wen-Qiong Chen, Zhuo-Fei Bi, Hou-Yang Chen, Tao Luo, Hai Hu, Wen-Bo Liao
BACKGROUND/AIMS: β-Elemene is a bioactive sesquiterpene compound that exhibits a potent anti-tumor effect and is used in various clinical applications. However, little is known about its effect on the male reproductive system. The objective of this study was to investigate the in vitro actions of β-elemene on human sperm function and elucidate the underlying mechanism. METHODS: The cytotoxicity of β-elemene toward MCF-10A, MDA-MD-231, and A549 cells was evaluated with cell proliferation and colony formation assays...
2018: Cellular Physiology and Biochemistry
Wen Huang, Hongmei Li, Chuhang Cheng, Chunhua Ren, Ting Chen, Xiao Jiang, Kaimin Cheng, Peng Luo, Chaoqun Hu
Soil salinization erodes the farmlands and poses a serious threat to human life, reuse of the saline-alkali lands as cultivated resources becomes increasingly prominent. Pacific white shrimp (Litopenaeus vannamei) is an important farmed aquatic species for the development and utilization of the saline-alkali areas. However, little is known about the adaptation mechanism of this species in terms of high-pH stress. In the present study, a transcriptome analysis on the gill tissues of L. vannamei in response to high-pH stress (pH 9...
2018: PloS One
Mao Dai, Rui Xiao, Luyao Cai, Tong Ge, Liping Zhu, Qinghua Hu
Pulmonary hypertension (PH) is a mortal disease featured with pulmonary vascular constriction and remodeling, right heart failure and eventual death. Several reports showed that high mobility group box 1 (HMGB1) appears to be critical for the development of PH, the underlying mechanism, however has not been revealed. Experiments from the current study demonstrated that the HMGB1 level was elevated in the lung tissue and blood plasma of rats after chronic hypoxia exposure and monocrotaline treatment. The HMGB1 was originally located within nucleus and translocated to cytoplasm of pulmonary artery smooth muscle cells (PASMCs) upon hypoxia exposure, a process that appeared mediated by endogenous H2 O2 ...
December 5, 2018: American Journal of Physiology. Cell Physiology
Jiao Hu, Yong-Zhong Jiang, Man Tang, Ling-Ling Wu, Hai-Yan Xie, Zhi-Ling Zhang, Dai-Wen Pang
Rapid and sensitive foodborne pathogen detection assay, which can be applied in multiple fields, is essential to timely diagnosis. Herein, we proposed a multi-signal readout lateral flow immunoassay for Salmonella typhimurium (S. typhi) detection. The assay employs colorimetric-fluorescent-magnetic nanospheres (CFMNs) as labels, which possess multi-functional: target separation and enrichment, multi-signal readout and two formats of quantitation. The assay for S. typhi detection involves magnetic separation and chromatography...
December 5, 2018: Analytical Chemistry
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