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Lyme Or Borrelia

Jennifer A Brown, Rex Allman, Barbara L Herwaldt, Elizabeth Gray, Hilda N Rivera, Yvonne Qvarnstrom, Natalie Kwit, Martin E Schriefer, Alison Hinckley, Pamela Pontones
No abstract text is available yet for this article.
October 19, 2018: MMWR. Morbidity and Mortality Weekly Report
Jie Feng, Wanliang Shi, Judith Miklossy, Genevieve M Tauxe, Conor J McMeniman, Ying Zhang
Lyme disease is the most common vector borne-disease in the United States (US). While the majority of the Lyme disease patients can be cured with 2⁻4 weeks antibiotic treatment, about 10⁻20% of patients continue to suffer from persisting symptoms. While the cause of this condition is unclear, persistent infection was proposed as one possibility. It has recently been shown that B. burgdorferi develops dormant persisters in stationary phase cultures that are not killed by the current Lyme antibiotics, and there is interest in identifying novel drug candidates that more effectively kill such forms...
October 16, 2018: Antibiotics
Fábio Videira Santos, Ana Cipriano, Miguel Araújo Abreu, Carlos Andrade, Rui Sarmento-Castro
Lyme disease is an endemic zoonosis, the most prevalent tick-transmitted infection in temperate areas of Europe, North America and Asia. It is a multisystemic disease with cutaneous, musculoskeletal, neurologic and cardiac manifestations, according to the stage of the disease. We describe a case of late neuroborreliosis in an Erasmus programme student living in Porto. We discuss the importance of the epidemiological suspicion, the clinical approach, the diagnostic criteria and the most adequate treatment.
September 28, 2018: Acta Médica Portuguesa
Jae Hyoung Im, JiHyeon Baek, Areum Durey, Hea Yoon Kwon, Moon-Hyun Chung, Jin-Soo Lee
BACKGROUND: Bites with tick-borne pathogens can cause various bacterial, viral, or parasitic diseases in humans. Tick-transmitted diseases are known as contributing factors to the increasing incidence and burden of diseases. The present article investigated the epidemiology of tick-borne diseases in South Korea. METHODS: The incidence and distribution of common tick-borne diseases in Korea (Lyme disease, Q fever, and severe fever with thrombocytopenia syndrome [SFTS]) were investigated and analyzed, using data from the Korea Centers for Disease Control and Prevention (KCDC) infectious disease reporting system...
October 17, 2018: Vector Borne and Zoonotic Diseases
Maciej Kowalec, Tomasz Szewczyk, Renata Welc-Falęciak, Edward Siński, Grzegorz Karbowiak, Anna Bajer
Bacteria of Rickettsiaceae and Anaplasmataceae families include disease agents spread by Ixodes ricinus ticks, the most common tick vector in Europe. The aim of the study was to compare the prevalence and co-infection prevalence of particular tick-transmitted Rickettsiales members: Rickettsia spp. (further referred as Rs), Anaplasma phagocytophilum (Ap), and "Candidatus Neoehrlichia mikurensis" (CNM) in I. ricinus ticks in two types of areas, different in terms of human impact: natural and urban. Using additional data, we aimed at investigating co-occurrence of these Rickettsiales with Borreliella spp...
October 16, 2018: Microbial Ecology
Deborah A Grosenbaugh, Karelle De Luca, Pierre-Yves Durand, Bradley Feilmeier, Kristopher DeWitt, Cecile Sigoillot-Claude, Marie-Line Sajous, Michael J Day, Frederic David
BACKGROUND: Prevention of Lyme disease in dogs in North America depends on effective vaccination against infection by the tick vector-born spirochete Borrelia burgdorferi. Most vaccines effectively prevent spirochete transmission to dogs during tick feeding based on immunization with the outer-surface lipoprotein A (OspA) of B. burgdorferi. More recently, vaccines containing additional OspC protein moieties have been introduced. These are designed to enhance protection by forming a second line of defense within the vertebrate host, where OspC expression replaces OspA as the dominant surface antigen...
October 16, 2018: BMC Veterinary Research
Vett K Lloyd, Ralph G Hawkins
Lyme disease arises from infection with pathogenic Borrelia species. In Canada, current case definition for confirmed Lyme disease requires serological confirmation by both a positive first tier ELISA and confirmatory second tier immunoblot (western blot). For surveillance and research initiatives, this requirement is intentionally conservative to exclude false positive results. Consequently, this approach is prone to false negative results that lead to underestimation of the number of people with Lyme disease...
October 15, 2018: Healthcare (Basel, Switzerland)
Eva George, Colton B Nielson, Vladimir Vincek
Borrelia burgdorferi, the causative organism of Lyme disease, has been linked to the development of scleroatrophic skin conditions including morphea, although this association remains controversial. The possibility that tick bite with or without concurrent Borrelia infection instigates that morphea development is important to recognize because this could prompt further workup for Lyme disease, or other tick-borne illness, which, when untreated, can have devastating consequences. Here, we report a case of a woman with a history of previous tick bite in the location of morphea...
October 9, 2018: American Journal of Dermatopathology
Lorraine Johnson, Mira Shapiro, Jennifer Mankoff
Lyme disease is caused by the bacteria borrelia burgdorferi and is spread primarily through the bite of a tick. There is considerable uncertainty in the medical community regarding the best approach to treating patients with Lyme disease who do not respond fully to short-term antibiotic therapy. These patients have persistent Lyme disease symptoms resulting from lack of treatment, under-treatment, or lack of response to their antibiotic treatment protocol. In the past, treatment trials have used small restrictive samples and relied on average treatment effects as their measure of success and produced conflicting results...
October 12, 2018: Healthcare (Basel, Switzerland)
Grzegorz Karbowiak, Beata Biernat, Joanna Stańczak, Joanna Werszko,, Tomasz Szewczyk, Hubert Sytykiewicz
The developmental cycles of all B. burgdorferi s.l. genospecies present typical, main pattern described in the 90thies. The simple scheme might be modified according to the biology of species and hosts preference. Central European genospecies of B. burgdorferi s.l. can be associated with four groups of hosts playing the role of animal reservoirs. The group 1 contains genospecies associated with rodents as primary animal reservoir – B. afzelii, B. garinii, B. burgdorferi sensu stricto, strains B. bavariensis (B...
2018: Annals of Parasitology
Constantin N Takacs, Zachary A Kloos, Molly Scott, Patricia A Rosa, Christine Jacobs-Wagner
Lyme disease is the most widely reported vector-borne disease in the United States. Its incidence is rapidly increasing and disease symptoms can be debilitating. The need to understand the biology of the disease agent, the spirochete Borrelia burgdorferi , is thus evermore pressing. Despite important advances in B. burgdorferi genetics, the array of molecular tools available for use in this organism remains limited, especially for cell biological studies. Here, we adapt a palette of bright and mostly monomeric fluorescent proteins for versatile use and multi-color imaging in B...
October 12, 2018: Applied and Environmental Microbiology
Erin Schillberg, Dorian Lunny, L Robbin Lindsay, Mark P Nelder, Curtis Russell, Mike Mackie, Dave Coats, Alex Berry, Kit Ngan Young Hoon
The range of Ixodes scapularis is expanding in Ontario, increasing the risk of Lyme disease. As an effective public health response requires accurate information on disease distribution and areas of risk, this study aims to establish the geographic distribution of I. scapularis and its associated pathogen, B. burgdorferi , in northwestern Ontario. We assessed five years of active and passive tick surveillance data in northwestern Ontario. Between 2013 and 2017, 251 I. scapularis were submitted through passive surveillance...
October 11, 2018: International Journal of Environmental Research and Public Health
Steven E Schutzer, Barbara A Body, Jeff Boyle, Bernard M Branson, Raymond J Dattwyler, Erol Fikrig, Noel J Gerald, Maria Gomes-Solecki, Martin Kintrup, Michel Ledizet, Andrew E Levin, Michael Lewinski, Lance A Liotta, Adriana Marques, Paul S Mead, Emmanuel F Mongodin, Segaran Pillai, Prasad Rao, William H Robinson, Kristian M Roth, Martin E Schriefer, Thomas Slezak, Jessica L Snyder, Allen C Steere, Jan Witkowski, Susan J Wong, John A Branda
Borrelia burgdorferi was discovered to be the cause of Lyme disease in 1983, leading to seroassays. The 1994 serodiagnostic testing guidelines predated a full understanding of key B. burgdorferi antigens and have a number of shortcomings. These serologic tests cannot distinguish active infection, past infection, or reinfection. Reliable direct-detection methods for active B. burgdorferi infection have been lacking in the past but are needed and appear achievable. New approaches have effectively been applied to other emerging infections and show promise in direct detection of B...
October 11, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
Maureen Laroche, Didier Raoult, Philippe Parola
Arthropods are small invertebrate animals, among which some species are hematophagous. It is during their blood meal that they can transmit pathogenic microorganisms that they may be harboring to the vertebrate host that they parasitize, which in turn will potentially develop a vector-borne disease. The transmission may occur directly through their bite, but also through contaminated feces. Zoonotic diseases, diseases that can naturally be transmitted between humans and animals, are a considerable part of emerging diseases worldwide, and a major part of them are vector-borne...
October 2018: Microbiology Spectrum
Ki Hwan Moon, Xiaowei Zhao, Hui Xu, Jun Liu, Md A Motaleb
Spirochetes possess a unique periplasmic flagellar motor component called the collar. However, little is known about the composition or function of the flagellar collar proteins. To identify a collar protein, we have inactivated almost all genes annotated as motility-related in the Borrelia burgdorferi genome and identified only FlbB, which comprises the base of the collar. Since the major components of the collar complex remained unidentified, we took advantage of a protein-protein interaction map developed in another spirochete, Treponema pallidum to identify proteins of unknown function that could be collar proteins...
October 10, 2018: Molecular Microbiology
Julia Enkelmann, Merle Böhmer, Volker Fingerle, Claudia Siffczyk, Dirk Werber, Martina Littmann, Sophie-Susann Merbecks, Carina Helmeke, Sabine Schroeder, Stefan Hell, Uwe Schlotthauer, Florian Burckhardt, Klaus Stark, Anika Schielke, Hendrik Wilking
Lyme borreliosis (LB) is the most commonly reported tick-borne disease in Germany. In 9/16 states, notification of erythema migrans (EM), acute neuroborreliosis (NB) and Lyme arthritis (LA) is mandatory. We describe incidence measures, time trends, geographical distribution and frequencies of manifestations to better understand LB epidemiology and target prevention measures. We used cases notified in the 9 states and confirmed by local health offices, 2013-2017, to calculate incidences by time, place and person...
October 8, 2018: Scientific Reports
Aman Dabir, Gauri Pawar
No abstract text is available yet for this article.
October 9, 2018: Neurology
Omid Salaami, Dennis Michael Manning
A 62-year-old woman was admitted with a 3-week history of atraumatic bilateral lower back pain, progressive ascending flaccid paralysis, hyponatraemia and constipation. She was otherwise in good health with only a recent diagnosis of acute gastroenteritis that preceded her presenting symptoms. Her initial laboratory evaluation was consistent with Syndrome of Inappropriate Antidiuretic Hormone (SIADH) but was otherwise unremarkable. MRI of the spine revealed bilateral diffuse nerve root enhancement from at least C6 to the conus level, suggesting an inflammatory process...
October 7, 2018: BMJ Case Reports
(no author information available yet)
No abstract text is available yet for this article.
October 8, 2018: Science Progress
Susan P Proctor, Matthew M Scarpaci, Alexis L Maule, Kristin J Heaton, Kathryn Taylor, Caitlin C Haven, Jennifer Rood, Maria Ospina, Antonia M Calafat
Wearing of permethrin treated clothing is becoming more prevalent in military and outdoor occupational and recreational settings, as a personal protection measure against vector borne diseases transmitted through arthropods (e.g., malaria, Lyme disease). The goal of the study was to prospectively examine permethrin exposure among new U.S. Army recruits who had just been issued permethrin-treated uniforms over a 10-week military training period and whether individual body composition (percent body fat, %BF) and physical workload (total energy expenditure, TEE) influenced the exposure...
October 4, 2018: Toxicology Letters
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