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Ulisses Ribaldo Nicolau, Victor Hugo Fonseca de Jesus, Eduardo Nóbrega Pereira Lima, Marclesson Santos Alves, Thiago Bueno de Oliveira, Louise De Brot Andrade, Virgilio Souza Silva, Paula Cacciatore Bes, Tadeu Ferreira de Paiva, Vinicius Fernando Calsavara, Andrea Paiva Gadelha Guimarães, Loureno Cezana, Paula Nicole Vieira Pinto Barbosa, Gislaine Cristina Lopes Machado Porto, Antônio Cássio Assis Pellizzon, Genival Barbosa de Carvalho, Luiz Paulo Kowalski
OBJECTIVE: The objective of this study was to assess the clinical value of 18-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) after the first cycle of induction chemotherapy (IC) in locally advanced squamous cell carcinoma of the head and neck (LASCCHN). METHODS AND FINDINGS: A prospective, single-arm, single center study was performed, with patients enrolled between February 2010 and July 2013.Patients (n = 49) with stage III/IVA-B LASCCHN who underwent IC with taxanes, cisplatin, and fluorouracil were recruited...
2018: PloS One
Eduardo de Arnaldo Silva Vellutini, Pedro Henrique Petit Becker, Luis Felipe Godoy, Nicolau Faria Correia Guerreiro, Romulo Loss Mattedi, Matheus Fernandes de de Oliveira
Background: Pituicytomas are considered World Health Organization Grade I malignancies. Until September 2017, a total of 81 cases of pituicytomas were diagnosed and described in literature. We present such a case in which histopathology shows an epithelioid pattern, a rare variant of pituicytoma. As far as we know, this is only the second such case described in the literature. Case Description: A 61-year-old male patient presented with complaints of progressive decrease in visual acuity for about 7 months, worse on the left side...
2018: Surgical Neurology International
Carolina Malagelada, Teodora Pribic, Barbara Ciccantelli, Nicolau Cañellas, Josep Gomez, Nuria Amigo, Anna Accarino, Xavier Correig, Fernando Azpiroz
BACKGROUND: Ingestion of a meal up to maximal tolerance induces unpleasant fullness sensation and changes in circulating metabolites. Our aim was to evaluate the relation between postprandial sensations and the metabolomic responses to a comfort meal. METHODS: In 32 non-obese healthy men, homeostatic sensations (hunger/satiety, fullness), hedonic sensations (digestive well-being, mood), and the metabolomic profile in plasma (low-molecular weight metabolites and lipoprotein profiles) were measured before and 20 minutes after a comfort meal (warm ham and cheese sandwich and juice; total 300 mL; 425 kcal)...
August 13, 2018: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
Juliana Dantas Rodrigues Santos, Eduardo Kenji Nunes Arashiro, Mário Felipe Alvarez Balaro, Joanna Maria Gonçalves Souza-Fabjan, Pedro Henrique Nicolau Pinto, Clara Vieira de Souza, Ceci Ribeiro Leite, Jeferson Ferreira da Fonseca, Felipe Zandonadi Brandão
This study evaluated the cervical transposition method as a tool to select ewes for embryo collection by transcervical route. Adult Santa Inês ewes (n=50) received day 0 protocol for superovulation treatments. The cervix transposition test was performed both at estrus and at the embryo collection time. The latter was preceded by hormonal cervical dilation. The sensitivity, specificity, positive predictive value, negative predictive value, and accuracy were 85.7%, 66.6%, 85.7%, 66.6%, and 80.0%, respectively...
August 12, 2018: Reproduction in Domestic Animals, Zuchthygiene
M C Barros-Filho, L A Reis-Rosa, M Hatakeyama, F A Marchi, T Chulam, C Scapulatempo-Neto, U R Nicolau, A L Carvalho, C A L Pinto, S A Drigo, L P Kowalski, S R Rogatto
OBJECTIVES: To identify potential molecular drivers associated with prognosis and response to treatment in advanced oropharyngeal squamous cell carcinomas (OPSCC). MATERIALS AND METHODS: Thirty-three OPSCC biopsies from untreated Brazilian patients were evaluated for human papilloma virus genotyping, genome wide copy number alterations and gene expression profiling. Data were integrated using CONEXIC algorithm. Validation with TCGA dataset and confirmation by RT-qPCR of candidate genes were performed...
August 2018: Oral Oncology
Yona Nicolau, Fayez Bany-Mohammed, Charles L Cai, Jacob V Aranda, Kay D Beharry
Vascular endothelial growth factor (VEGF) is a potent mitogen that regulates proliferation, migration, and tube formation of endothelial cells (EC). VEGF has recently become a target for severe retinopathy of prematurity (ROP) therapy. We tested the hypothesis that a specific VEGF isoform and/or receptor acts synergistically with insulin-like growth factor (IGF)-I to alter normal retinal microvascular EC angiogenesis and RNA interference can be used to reverse VEGF effects. We used small interfering RNA (SiRNA) transfection to target VEGF isoforms, IGFs, and their receptors in human retinal microvascular endothelial cells (HRECs)...
2018: American Journal of Translational Research
Daniel Cañueto, Reza M Salek, Xavier Correig, Nicolau Cañellas
NMR spectroscopy is a technology that is widely used in metabolomic studies. The information that these studies most commonly use from NMR spectra is the metabolite concentration. However, as well as concentration, pH and ionic strength information are also made available by the chemical shift of metabolite signals. This information is typically not used even though it can enhance sample discrimination, since many conditions show pH or ionic imbalance. Here, we demonstrate how chemical shift information can be used to improve the quality of the discrimination between case and control samples in three public datasets of different human matrices...
August 8, 2018: Scientific Reports
Anna García-Altés, Dolores Ruiz-Muñoz, Cristina Colls, Montse Mias, Nicolau Martín Bassols
BACKGROUND: The aim of this study is to analyse the health status, the use of public healthcare services and the consumption of prescription drugs in the population of Catalonia, taking into consideration the socioeconomic level of individuals and paying special attention to vulnerable groups. METHODS: Cross-sectional study of the entire population resident in Catalonia in 2015 (7.5 million people) using administrative records. Twenty indicators are analysed related to health, the use of healthcare services and consumption of prescription drugs...
August 6, 2018: Journal of Epidemiology and Community Health
Pedro Fatjó Gómez, Francisco Muñoz Pradas, Roser Nicolau-Nos
INTRODUCTION: studies of the nutritional and epidemiologic transition in Spain do not seem to have used the report "Spain: Nutrition Survey of the Armed Forces" (SNSAF)" conducted in 1958 by the Interdepartamental Committee on Nutrition for National Defence (ICNND) of the United States of America. OBJECTIVE: this article provides an introduction to this report with an assessment of its methodology and results. MATERIALS AND METHODS: examine the objectives, approach and process of implementation of the survey conducted on a sample of 10,727 Spanish soldiers from April to June in 1958...
June 4, 2018: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
Salvador Calatayud, Francisco J Medina-Albaladejo, Roser Nicolau, Josep Pujol-Andreu
INTRODUCTION: studies about the Nutritional Transition in Spain (NTS) until the mid-20th century are based on direct, and heavily aggregated, consumption estimates, a methodology that obscures important aspects of this process. OBJECTIVE: to show the new possibilities of study opened by the analysis of hospital diets and to suggest new NTS indicators based on the menus provided by the Hospital Provincial in Valencia (HPV) and the Hospital Sant Jaume in Olot (HSJO), between 1900 and 1936...
June 4, 2018: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
Anette M Høye, Sofie D Tolstrup, Edward R Horton, Monica Nicolau, Helen Frost, Jung H Woo, Jeremy P Mauldin, Arthur E Frankel, Thomas R Cox, Janine T Erler
Every year more than 8 million people suffer from cancer-related deaths worldwide [1]. Metastasis, the spread of cancer to distant sites, accounts for 90% of these deaths. A promising target for blocking tumor progression, without causing severe side effects [2], is Tumor Endothelial Marker 8 (TEM8), an integrin-like cell surface protein expressed predominantly in the tumor endothelium and in cancer cells [3, 4]. Here, we have investigated the role of TEM8 in cancer progression, angiogenesis and metastasis in invasive breast cancer, and validated the main findings and important results in colorectal cancer...
July 10, 2018: Oncotarget
Lindsay M Avery, David P Nicolau
Ceftazidime/avibactam plus aztreonam (CZA+ATM) is an emerging option to combat carbapenemase-producing Enterobacteriaceae (CPE) expressing resistance via multiple β-lactamases within Ambler classes A, B, C, and D. The benefit of this combination is apparent when the pathogen-specific resistance genotype is characterized. However, rapid molecular diagnostic systems may be unavailable to allow this precision medicine-based approach. Using synergy tests with antibiotic gradient diffusion strips (GDS), we aimed to prove that the defined phenotypic profile of CPE is reliably predicted by the genotype to confirm the utility of this method as a phenotypic profiling tool for use in the clinical setting...
July 22, 2018: International Journal of Antimicrobial Agents
J M Molina Aragonés, R Bausà Peris, R Carreras Valls, A Carrillo Castillo, F Fiblà Nicolau, E Gaynés Palou, J Guerrero Monge, J Inglés Torruella, J A López Muñoz, E Martinez Martínez-Carrasco, J Matllo Aguilar, J A Medina Lavela, M T Mestre Prad, P Peña García, S Rodriguez Vallecillos, G Tapias Oller, M Vilardell Ynaraja
The presence of formaldehyde at workplace remains significant. Exposure to it results in local irritation of the eye, nose and upper respiratory tract mucous membranes, and it has been chronically related to a higher risk of cancer development at the paranasal sinuses, naso-oropharynx and lungs. The aim of our work has been the updating of the bibliography and the categorization of the most up to date scientific evidence of formaldehyde effects on human body. Bibliographic search on the electronic database Medline / PubMed, restricted to the last 10 years through a combination of free and controlled language...
July 2018: Archivos de Prevención de Riesgos Laborales
Dmitry Ponomarev, Vladimir Boboshko, Vladimir Shmyrev, Igor Kornilov, Ilya Bondarenko, Ilya Soynov, Alexey Voytov, Stanislav Polyanskih, Oleg Strunin, Alexander Bogachev, Giovanni Landoni, Caetano Nigro Neto, Gretel Oliveira Nicolau, Zhang Wen, Mikhail Evdokimov, Shahrijar Sulejmanov, Aleksei Chernogrivov, Alexander Karaskov, Vladimir Lomivorotov
No abstract text is available yet for this article.
July 17, 2018: Contemporary Clinical Trials
Henrique Rocha Mendonça, Juliana Nicolau Aranha Carvalho, Carla Andreia Abreu, Domethila Mariano de Souza Aguiar Dos Santos, Julia Rios Carvalho, Suelen Adriani Marques, Karin da Costa Calaza, Ana Maria Blanco Martinez
Diabetic retinopathy is the leading cause of acquired blindness in working-age individuals. Recent work has revealed that neurodegeneration occurs earlier than vascular insult and that distal optic nerve damage precedes retinal degeneration and vascular insult. Since we have shown that optic nerve degeneration is reduced after optic nerve crush in Galectin-3 knockout (Gal-3 -/-) mice, we decided to investigate whether Gal-3 -/- could relieve inflammation and preserve both neurons and the structure of the retina and optic nerve following 8 weeks of diabetes...
July 14, 2018: Brain Research
Jose Nativi-Nicolau, Mathew S Maurer
PURPOSE OF REVIEW: The present article provides an update about the recent advances in the diagnosis and management of the most common types of cardiac amyloidosis, including light chain, wild-type transthyretin (ATTRwt), and mutant transthyretin (ATTRm). RECENT FINDINGS: The document reviews the utility of diagnostic tools including innovative echocardiographic indices, magnetic resonance T1 mapping and measurement of extracellular volume, and the role and validation of bone scintigraphy for the noninvasive assessment of ATTR amyloidosis...
July 13, 2018: Current Opinion in Cardiology
María Eugenia Taverna, Carlos Alberto Busatto, Maia Raquel Lescano, Verónica Viviana Nicolau, Cristina Susana Zalazar, Gregorio Raúl Meira, Diana Alejandra Estenoz
Lignins are natural polymers of the lignocellulosic biomass. Nowadays, there is a growing interest in developing value-added products based on lignins due to their renewability, low cost and abundance. In this work, lignin microspheres from organosolv and ionic isolation processes were prepared for the controlled release of atrazine. Microspheres were prepared by the solvent extraction/evaporation technique. The controlled release of atrazine from organosolv and ionic lignins microparticles was studied in water...
July 9, 2018: Journal of Hazardous Materials
Nicolau Casal, Maria Font-I-Furnols, Marina Gispert, Xavier Manteca, Emma Fàbrega
Animal welfare can be considered an ethical attribute of product quality, but consumers should appreciate its added value. The aim of this study was to evaluate consumer's acceptability, preference, and the meat and carcass quality of pigs reared with two stress-reducing strategies: supplementation of an herbal compound (HC) containing Valeriana officinalis and Passiflora incarnata , and environmental enrichment (EE) by the provision of hemp ropes, sawdust, and rubber balls. A total of 56 pigs were divided in four treatments in two pens of seven pigs per treatment (2 × 2 factorial design)...
July 16, 2018: Animals: An Open Access Journal From MDPI
James M Kidd, Kamilia Abdelraouf, Tomefa E Asempa, Romney M Humphries, David P Nicolau
The Clinical Laboratory Standards Institute (CLSI) daptomycin MIC susceptibility breakpoint for the treatment of enterococcal infections is ≤4 μg/mL. However, patients receiving daptomycin for enterococci with MICs ≤4 μg/mL may experience treatment failures. We assessed the pharmacodynamics of daptomycin against enterococci in a neutropenic murine thigh infection model and determined exposures necessary for bacteriostasis and 1 log10 CFU reduction against Enterococcus faecalis and Enterococcus faecium We further characterized daptomycin efficacy at clinically achievable exposures...
July 16, 2018: Antimicrobial Agents and Chemotherapy
Marguerite L Monogue, Sara Giovagnoli, Caterina Bissantz, Claudia Zampaloni, David P Nicolau
Urinary tract infections (UTIs) are a tremendous burden to the healthcare system due to the vast number of infections resulting in antibiotic therapy and/or hospitalization. Additionally, these infections are frequently caused by multi-drug resistant (MDR) organisms, limiting the availability of effective antimicrobials. Nacubactam is a novel non-β-lactam-β-lactamase inhibitor with in vitro activity against class A and class C β-lactamases. Nacubactam is being developed in combination with meropenem, providing broad-spectrum activity in addition to improved stability against common β-lactamases...
July 16, 2018: Antimicrobial Agents and Chemotherapy
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