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Eder Silva de Oliveira, Ângela Junges, Nicolau Sbaraini, Fábio Carrer Andreis, Claudia Elizabeth Thompson, Charley Christian Staats, Augusto Schrank
Cell walls are involved in manifold aspects of fungi maintenance. For several fungi, chitin synthesis, degradation and recycling are essential processes required for cell wall biogenesis; notably, the activity of β-N-acetylglucosaminidases (NAGases) must be present for chitin utilization. For entomopathogenic fungi, such as Metarhizium anisopliae, chitin degradation is also used to breach the host cuticle during infection. In view of the putative role of NAGases as virulence factors, this study explored the transcriptional profile and evolution of putative GH20 NAGases (MaNAG1 and MaNAG2) and GH3 NAGases (MaNAG3 and MaNAG4) identified in M...
December 10, 2018: Genetics and Molecular Biology
Tasleem Arif, Konchok Dorjay
Nicolau syndrome (NS) is a type of adverse skin reaction occurring after parenteral drug injection. In certain conditions, it can cause ischemic necrosis of the skin and the underlying adipose tissue. The actual cause of NS is not clear though inflammation, vasospasm, and thromboembolic occlusion of blood vessels have been proposed. In this case presentation, we report an interesting case of a 30-year-old man who turned out be human immunodeficiency virus (HIV) positive on investigations, developed extensive purpuric lesions of his skin on left buttock and then spread to the trunk and shoulders after receiving intramuscular injection of paracetamol...
July 2018: Journal of Cutaneous and Aesthetic Surgery
Diego Rodrigues Pessoa, Davidson Ribeiro Costa, Bruno de Moraes Prianti, David Ribeiro Costa, Carolina Alves Delpasso, Emília Ângela Lo Schiavo Arisawa, Renata Amadei Nicolau
This case report aims to evaluate the treatment of Temporomandibular Disorder (TMD) of muscular origin by associating facial massage (FM), dry needling (DN), and low-level laser therapy (LLLT). The pre- and post-treatment evaluations consisted of clinical examinations based on the Research Diagnostic Criteria (RDC) for TMD, pain intensity quantification by means of the Visual Analog Scale (VAS), mandibular movement measurement, and electromyographic (EMG) analysis of the masseter and temporal muscles. Post-therapy assessment indicated a decrease in pain sites of 58%, in pain intensity mean (1...
November 29, 2018: CoDAS
Paul Bonnevialle, Pierre-Sylvain Marcheix, Xavier Nicolau, Marine Arboucalot, Marie Lebaron, Christophe Chantelot, Didier Mainard, Matthieu Ehlinger
INTRODUCTION: Interprosthetic femoral fractures (IFF) are becoming more frequent; however they have not been the subject of many publications and the largest study on this topic includes only 30 cases. The complication rate and clinical outcomes have only been evaluated in small case series. This led us to conduct a retrospective, multicenter, observational study in IFF patients with at least 12 months' follow-up to (1) determine the mortality and morbidity (2) determine the clinical and radiological outcomes and (3) identify elements of the treatment indications...
December 1, 2018: Orthopaedics & Traumatology, Surgery & Research: OTSR
Belinda Nicolau, Sreenath Madathil
ARTICLE TITLE AND BIBLIOGRAPHIC INFORMATION: Association between dental caries and BMI in children: a systematic review and meta-analysis. Chen D, Zhi Q, Zhou Y, Tao Y, Wu L, Lin H.Caries Res 2018;52:230-45. SOURCE OF FUNDING: None declared. TYPE OF STUDY/DESIGN: Systematic review with meta-analysis.
December 2018: Journal of Evidence-based Dental Practice
Safa S Almarzoky Abuhussain, Michelle A Burak, Kelsey N Kohman, Gabrielle Jacknin, Serina B Tart, Athena L V Hobbs, Danyel K Adams, Michael D Nailor, Katelyn R Keyloun, David P Nicolau, Joseph L Kuti
BACKGROUND: Limited research has assessed patient preferences for treatment disposition and antibiotic therapy of acute bacterial skin and skin structure infection (ABSSSI) in the emergency department (ED). Understanding patient preference for the treatment of ABSSSI may influence treatment selection and improve satisfaction. METHODS: A survey was conducted across 6 US hospital EDs. Patients with ABSSSI completed a baseline survey assessing preferences for antibiotic therapy (intravenous versus oral) and treatment location...
December 4, 2018: BMC Health Services Research
Ana Motos, Joseph L Kuti, Gianluigi Li Bassi, Antoni Torres, David P Nicolau
Describing the disposition of antimicrobials agents at the site of infection is crucial to guide optimal dosing for investigational agents. For antibiotics in development for nosocomial pneumonia, concentrations are frequently determined in the epithelial lining fluid (ELF) of the lung from a bronchoscopy at a single time point. The influence of profiles constructed from a single ELF concentration point for each subject has never been reported. This study compares the pharmacokinetics of two β-lactams, ceftolozane and piperacillin, among different ELF sampling approaches using simulated human regimens in a swine pneumonia model...
December 3, 2018: Antimicrobial Agents and Chemotherapy
Stefano G D Lemos, Luiz A Benvenuti, Vera D Aiello, José C Nicolau, Expedito E Ribeiro, Henrique B Ribeiro
No abstract text is available yet for this article.
November 29, 2018: Coronary Artery Disease
M A Ruescas-Nicolau, M L Sánchez-Sánchez, E Marques-Sule, G V Espí-López
OBJECTIVE: To examine the immediate effect on dynamic and static balance of a manual protocol of plantar stimulation in healthy subjects. MATERIALS AND METHOD: Of the 144 healthy and physically active volunteers recruited, 98 subjects participated. Subjects were randomly assigned and allocated to the experimental group (EG) (n= 50), in which a 10-min manual protocol of plantar stimulation was applied on the right foot, or to the control group (CG) (n= 48). The change scores of the modified Star Excursion Balance Test (mSEBT) and the Unipedal Stance Test (UPST) were used to assess the immediate effect of the protocol on dynamic and static balance, respectively...
November 23, 2018: Journal of Back and Musculoskeletal Rehabilitation
M C Rota, A Bella, M G Caporali, A Nicolau, V Drasar, M L Ricci, M Scaturro, M Gumá, S Crespi
According to European Guidelines for Legionnaires' Disease prevention and control, travel-associated Legionnaires' disease (TALD) cases are managed differently if classified as sporadic or as part of a cluster and more stringent control measures are deployed after clusters are identified. In this study, we propose to modify the current cluster definition: 'two or more cases of Legionnaires' disease (LD) who stayed at, or visited, the same commercial accommodation site 2-10 days before onset of illness and whose onset is within the same 2-year period' with a new cluster definition, i...
December 3, 2018: Epidemiology and Infection
Sreenath Madathil, Christine Blaser, Belinda Nicolau, Hugues Richard, Marie-Élise Parent
Background: Previous studies on socioeconomic position (SEP) and risk of prostate cancer (PCa) have produced contradictory results. Most measured SEP only once during the individuals' life span. The aim of the study was to identify life course models that describe best the relationship between SEP measured during childhood/adolescence, early- and late-adulthood, and risk of PCa overall as well as according to tumor aggressiveness at diagnosis. Methods: We used data from a population-based case-control study of PCa conducted in the predominantly French-speaking population in Montreal, Canada...
2018: Frontiers in Oncology
Alexandre A B A da Costa, Felipe D'Almeida Costa, Daniel Vilarim Araújo, Marcos Pedro Guedes Camandaroba, Victor Hugo Fonseca de Jesus, Audrey Oliveira, Ana Caroline Fonseca Alves, Carlos Stecca, Larissa Machado, Andrea Cruz Feraz de Oliveira, Thiago Bueno de Oliveira, Ulisses Ribaldo Nicolau, Vladmir Cláudio Cordeiro de Lima
There is no established biomarker for cetuximab efficacy in recurrent head and neck squamous cell carcinoma (HNSCC). The aim of the present study was to evaluate the prognostic and predictive impact of PTEN, cMET, and p16 expression in recurrent HNSCC. In this retrospective study, 112 patients with recurrent HNSCC received chemotherapy (CT) alone (n = 37) or chemotherapy with cetuximab (n = 75). PTEN, cMET, and p16 protein expression were evaluated by immunohistochemistry. The median overall survival (mOS) for the patients treated with cetuximab + CT versus CT alone was 11...
November 26, 2018: Medical Oncology
Ana Messias, Pedro Nicolau, Fernando Guerra
AIM: To compare clinical and radiographic outcomes of dental implants with different neck characteristics. METHODS: A protocol-oriented search aimed at the question: "In patients subjected to tooth replacement with screw-type dental implants does the modification of the implant neck macro or micro-geometry contribute to the improvement of survival rates and maintenance of the peri-implant marginal bone levels?" Primary outcomes were survival and marginal bone level (MBL) changes evaluated on randomized controlled trials with >10 participants and follow-up >1 year...
November 22, 2018: Clinical Oral Implants Research
M C Bento, R Canha, C Eira, J Vingada, L Nicolau, M Ferreira, M Domingo, L Tavares, A Duarte
Herpesvirus (HVs) infection has already been reported in cetaceans, but available information on its epidemiology is scarce. In this study we surveyed a total of 179 cetaceans belonging to 6 different species. Samples were obtained from cetaceans stranded along the Portuguese coastline, belonging to populations that roam the north-east region of the Atlantic Ocean. Detection of HVs was performed by conventional nested PCR. Amplicons were sequenced by Sanger's method and sequences used to construct phylogenetic trees by Maximum Likelihood method...
November 14, 2018: Infection, Genetics and Evolution
Falco C M J M van Delft, Giulia Ipolitti, Dan V Nicolau, Ayyappasamy Sudalaiyadum Perumal, Ondřej Kašpar, Sara Kheireddine, Sebastian Wachsmann-Hogiu, Dan V Nicolau
On-chip network-based computation, using biological agents, is a new hardware-embedded approach which attempts to find solutions to combinatorial problems, in principle, in a shorter time than the fast, but sequential electronic computers. This analytical review starts by describing the underlying mathematical principles, presents several types of combinatorial (including NP-complete) problems and shows current implementations of proof of principle developments. Taking the subset sum problem as example for in-depth analysis, the review presents various options of computing agents, and compares several possible operation 'run modes' of network-based computer systems...
December 6, 2018: Interface Focus
Vivian Francilia Silva Kahl, Daniel Simon, Melissa Rosa de Souza, Vieira Henrico da Rosa, Caroline Nicolau, Fernanda R Da Silva, Katia Kvitko, Alessandra Peres, Gilson Pires Dorneles, Cláudia Telles de Souza, Johnny Ferraz Dias, Juliana Da Silva
Pesticides are one of the most frequently investigated chemical, due to their multiple uses in agricultural and public health areas. This study evaluates lymphocytes CBMN (cytokinesis-block micronucleus cytome assay), inflammatory markers, inorganic elements in blood samples, and the relationship of these parameters with XRCC1Arg194Trp, OGG1Ser326Cys and PON1Gln192Arg polymorphisms in a population of tobacco farmers. The study population comprised 129 agricultural workers exposed to pesticides and 91 nonexposed...
December 2018: Mutation Research
Constanze Kiese, Hans-Peter Landgraf, Anna-Lena Danzer, Benedikt Schickling, Anna Nicolau-Torra, Torsten Reitmeier, Wilhelm Schulter-Mattler, Dietrich von Schweinitz, Herrmann Ketterl
The purpose of this study was to develop a user-friendly presentation of surface-EMG data in near-time for intraoperative nerve-monitoring. We have built a novel surface-EMG probe as a diagnostic device to investigate innervation patterns of sphincter muscles in further clinical diagnostic studies. S-EMG data were recorded from 20 healthy volunteers from the orbicularis oris muscles. We developed an automated analysis based on correlation in order to find phase inversions and thus innervation zones automatically...
July 2018: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
Juan Carlos Perdomo Puentes, Hirondina Rocha, Sara Nicolau, Gonçalo Ferrão
Objective: Identification of palliative care needs in patients with liver cirrhosis using the MELD/Na score and the Child-Pugh score. Materials and Methods: A retrospective study of hospitalized patients with hepatic cirrhosis between January 2015 and December 2016 using the Child-Pugh score and the MELD/Na score in January 2018. Results: Recognizing end-of-life patients (the past 12 months of life) is a challenge for health professionals, especially in diseases with poorly defined criteria, such as cirrhosis of the liver...
October 2018: Indian Journal of Palliative Care
Ana Motos, James M Kidd, David P Nicolau
Pneumonia, including community-acquired bacterial pneumonia, hospital-acquired bacterial pneumonia, and ventilator-acquired bacterial pneumonia, carries unacceptably high morbidity and mortality. Despite advances in antimicrobial therapy, emergence of multidrug resistance and high rates of treatment failure have made optimization of antibiotic efficacy a priority. This review focuses on pharmacokinetic and pharmacodynamic approaches to antibacterial optimization within the lung environment and in the setting of critical illness...
December 2018: Clinics in Chest Medicine
Lavinia L Ruta, Claudia V Popa, Ioana Nicolau, Ileana C Farcasanu
Epigallocatechin-3-O-gallate (EGCG), the main green tea component, is intensively studied for its anti-oxidant, anti-inflammatory, anti-microbial and anti-cancer effects. In the present study, a screen on a Saccharomyces cerevisiae gene deletion library was performed to identify conditions under which EGCG had deleterious rather than beneficial effects. Two genes were identified whose deletion resulted in sensitivity to EGCG: FET3 and FTR1, encoding the components of the Fet3/Ftr1 high-affinity iron uptake system, also involved in Cu(I)/Cu(II) balance on the surface of yeast cells...
November 15, 2018: Food Chemistry
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