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Safa S Almarzoky Abuhussain, Michelle A Burak, Danyel K Adams, Kelsey N Kohman, Serina B Tart, Athena L V Hobbs, Gabrielle Jacknin, Michael D Nailor, Katelyn R Keyloun, David P Nicolau, Joseph L Kuti
Background: Acute bacterial skin and skin structure infections (ABSSSIs) are a frequent cause of emergency department (ED) visits. Providers in the ED have many decisions to make during the initial treatment of ABSSSI. There are limited data on the patient factors that influence these provider decisions. Methods: An anonymous survey was administered to providers at 6 EDs across the United States. The survey presented patient cases with ABSSSIs ≥75 cm2 and escalating clinical scenarios including relapse, controlled diabetes, and sepsis...
October 2018: Open Forum Infectious Diseases
Ramon Margalef, Marc Sisquella, Marc Bosque, Clara Romeu, Orlando Mayoral, Sonia Monterde, Mercedes Priego, Rafael Guerra-Perez, Nicolau Ortiz, Josep Tomas, Manel M Santafe
Myofascial pain syndrome is one of the most common forms of muscle pain. In this syndrome pain is originated by the so-called trigger points, which consists of a set of palpable contraction knots in the muscle. It has been proposed that a high spontaneous neurotransmission may be involved in the generation of these contraction knots. To confirm this hypothesis, we exposed mouse muscles to an anticholinesterasic agent to increase the neurotransmision in the synaptic cleft in two different conditions, in vivo and ex vivo experiments...
October 11, 2018: Journal of Applied Physiology
Eduardo de Souza Nicolau, Kevin Augusto Farias de Alvarenga, Helia Tenza-Ferrer, Matheus Carvalho Alves Nogueira, Fernanda Donizete Rezende, Nycolle Ferreira Nicolau, Mélcar Collodetti, Débora Marques de Miranda, Luiz Alexandre Viana Magno, Marco Aurélio Romano-Silva
Transcranial direct current stimulation (tDCS) is a non-invasive neuromodulation technique proposed as an alternative or complementary treatment for several neuropsychiatric diseases. The biological effects of tDCS are not fully understood, which is in part explained due to the difficulty in obtaining human brain tissue. This protocol describes a tDCS mouse model that uses a chronically implanted electrode allowing the study of the long-lasting biological effects of tDCS. In this experimental model, tDCS changes the cortical gene expression and offers a prominent contribution to the understanding of the rationale for its therapeutic use...
September 23, 2018: Journal of Visualized Experiments: JoVE
Anderson Alexsander Rodrigues Teixeira, Lucas Fernandes Ferreira, Bruno Nunes Ferraz De Abreu, Euler Nicolau Sauaia Filho, Francisco Ramos Junior
Background: The posterior longitudinal ligament (PLL) extends from the foramen magnum to the sacrum. In some cases, it becomes calcified/ossified; the term for this is ossification of the PLL (OPLL). Case Description: A 50-year-old female presented with acute sphincter dysfunction and paraparesis attributed to T2-T4 OPLL. The patient underwent a C7-T5 laminectomy to decompress the spinal cord. After 1 postoperative week, and certainly by 6 months postoperatively, the patient's motor and sensory deficits showed improvement...
2018: Surgical Neurology International
Erin A Bohula, Benjamin M Scirica, Silvio E Inzucchi, Darren K McGuire, Anthony C Keech, Steven R Smith, Estella Kanevsky, Sabina A Murphy, Lawrence A Leiter, Jamie P Dwyer, Ramon Corbalan, Christian Hamm, Lee Kaplan, Jose Carlos Nicolau, Ton Oude Ophuis, Kausik K Ray, Mikhail Ruda, Jindrich Spinar, Tushar Patel, Wenfeng Miao, Carlos Perdomo, Bruce Francis, Shobha Dhadda, Marc P Bonaca, Christian T Ruff, Marc S Sabatine, Stephen D Wiviott
BACKGROUND: There is a direct relationship between bodyweight and risk of diabetes. Lorcaserin, a selective serotonin 2C receptor agonist that suppresses appetite, has been shown to facilitate sustained weight loss in obese or overweight patients. We aimed to evaluate the long-term effects of lorcaserin on diabetes prevention and remission. METHODS: In this randomised, double-blind, placebo-controlled trial done in eight countries, we recruited overweight or obese patients (body-mass index ≥27 kg/m2 ) with or at high risk for atherosclerotic vascular disease...
October 3, 2018: Lancet
Gilberto de Castro, Gustavo V Alves, Ana F Castro, Aline L F Chaves, Pedro De Marchi, Thiago B de Oliveira, Fernando L Dias, Rodrigo S C Guindalini, Ulisses R Nicolau, Andrey Soares, Paulo A R Mora
Squamous-cell carcinoma of the head and neck (SCCHN) is an important problem in Brazil, where epidemiological and socioeconomic features often create barriers to the implementation of combined modalities with curative potential. Cisplatin improves the efficacy of radiotherapy in the adjuvant treatment of localized SCCHN and in the definitive therapy of locally advanced disease. However, the addition of high-dose cisplatin to radiotherapy increases treatment toxicity and is not always warranted. A panel of experts convened in Sao Paulo, Brazil, for discussions and recommendations regarding the use of high-dose cisplatin in combination with radiotherapy in SCCHN...
November 2018: Critical Reviews in Oncology/hematology
Roberto Jun Arai, Irene de Lourdes Noronha, José Carlos Nicolau, Charles Schmidt, Gustavo Moreira de Albuquerque, Kenneth W Mahaffey, Eduardo Moacyr Krieger, José Otávio Costa Auler Júnior
No abstract text is available yet for this article.
September 21, 2018: Clinics
Jean-Christophe Lutz, Alexandre Hostettler, Vincent Agnus, Stéphane Nicolau, Daniel George, Luc Soler, Yves Rémond
Orthognathic surgery belongs to the scope of maxillofacial surgery. It treats dentofacial deformities consisting in discrepancy between the facial bones (upper and lower jaws). Such impairment affects chewing, talking, and breathing and can ultimately result in the loss of teeth. Orthognathic surgery restores facial harmony and dental occlusion through bone cutting, repositioning, and fixation. However, in routine practice, we face the limitations of conventional tools and the lack of intraoperative assistance...
October 1, 2018: Surgical Innovation
Kathryn F A Clancy, Sebastien Dery, Veronique Laforte, Prasad Shetty, David Juncker, Dan V Nicolau
The uniformity of the protein patterns, their shape, and the contrast between the fluorescence signal of the pattern and the background, critically modulate the quantitative accuracy of the microarray-derived data. While significant research focused of the identification of the factors that impact the protein microarray patterns, these studies usually have focused on the optimization of one set of these factors, e.g., how the spot uniformity is affected by different additives, or by different surfaces. However, the complex interaction between proteins, carrier fluids, surfaces, and patterning methodologies used would suggest a systematic and more comprehensive study that considers all these parameters, as well as their inter-relationship...
September 7, 2018: Biosensors & Bioelectronics
Ramón Corbalán, José Carlos Nicolau, José López-Sendon, Armando Garcia-Castillo, Rodrigo Botero, Gustavo Sotomora, Manuel Horna, Christian T Ruff, Rose A Hamershock, Laura T Grip, Elliott M Antman, Eugene Braunwald, Robert P Giugliano
BACKGROUND: There is limited information about the use of antithrombotic therapies and outcomes of Latin American (LatAm) subjects with atrial fibrillation. The global ENGAGE AF-TIMI 48 (Effective Anticoagulation With Factor Xa Next Generation Atrial Fibrillation-Thrombolysis In Myocardial Infarction 48) trial compared the efficacy and safety of edoxaban versus warfarin over a median follow-up of 2.8 years. OBJECTIVES: The authors aimed to compare adjusted outcomes in Latin America versus outside Latin America and to compare outcomes stratified by anticoagulant treatment and region...
September 25, 2018: Journal of the American College of Cardiology
Wadha Alfouzan, Rita Dhar, David P Nicolau
Limited data are available on susceptibilities of these organisms to some of the recently made accessible antimicrobial agents. The in vitro activities of newer antibiotics, such as, ceftolozane/tazobactam (C/T) and ceftazidime/avibactam (CZA) along with some "older" antibiotics, for example fosfomycin (FOS) and colistin (CL) were determined against selected strains (resistant to ≥ 3 antimicrobial agents) of Escherichia coli , Klebsiella pneumoniae , and Pseudomonas aeruginosa . Minimum inhibitory concentrations (MIC) were determined by Clinical and Laboratory Standards Institute microbroth dilution...
September 17, 2018: Pathogens
Ulf Neumann, Mike Ufer, Laura H Jacobson, Marie-Laure Rouzade-Dominguez, Gunilla Huledal, Carine Kolly, Rainer M Lüönd, Rainer Machauer, Siem J Veenstra, Konstanze Hurth, Heinrich Rueeger, Marina Tintelnot-Blomley, Matthias Staufenbiel, Derya R Shimshek, Ludovic Perrot, Wilfried Frieauff, Valerie Dubost, Hilmar Schiller, Barbara Vogg, Karen Beltz, Alexandre Avrameas, Sandrine Kretz, Nicole Pezous, Jean-Michel Rondeau, Nicolau Beckmann, Andreas Hartmann, Stefan Vormfelde, Olivier J David, Bruno Galli, Rita Ramos, Ana Graf, Cristina Lopez Lopez
The beta-site amyloid precursor protein cleaving enzyme-1 (BACE-1) initiates the generation of amyloid-β (Aβ), and the amyloid cascade leading to amyloid plaque deposition, neurodegeneration, and dementia in Alzheimer's disease (AD). Clinical failures of anti-Aβ therapies in dementia stages suggest that treatment has to start in the early, asymptomatic disease states. The BACE-1 inhibitor CNP520 has a selectivity, pharmacodynamics, and distribution profile suitable for AD prevention studies. CNP520 reduced brain and cerebrospinal fluid (CSF) Aβ in rats and dogs, and Aβ plaque deposition in APP-transgenic mice...
September 17, 2018: EMBO Molecular Medicine
S Dobroiu, F C M J M van Delft, J Aveyard-Hanson, Prasad Shetty, D V Nicolau
Continuous improvements of the fluorescence-based sensitivity and specificity, required for high throughput screening, diagnostics, and molecular biology studies, are usually addressed by better readout systems, or better reporting elements. However, while Fluorescence Interference Contrast (FLIC), which modulates the fluorescence by materials-based parameters, has been used for decades to measure biomolecular interactions at nanometer-precision, e.g., for the study of molecular motors and membrane processes, it has been seldom used for high throughput or diagnostic microdevices...
September 7, 2018: Biosensors & Bioelectronics
A Blind, C Lenormand, C Schissler, B Cribier, D Lipsker
BACKGROUND: Subcutaneous glatiramer acetate, commercialized under the name of Copaxone® , is licensed for the treatment of relapsing multiple sclerosis. Its major adverse effects are skin reactions at the injection site. Nicolau syndrome is a rare but serious iatrogenic accident. Herein we report a case seen in a setting of change of dosage and administration rate of Copaxone® . PATIENTS AND METHODS: A 64-year-old woman, treated since 2010 with daily sub-cutaneous injections of Copaxone® 20mg/L, reported the appearance of a painful, indurated and erythematous plaque in the suprapubic area following changeover to 40mg/mL injections three times weekly...
September 11, 2018: Annales de Dermatologie et de Vénéréologie
Belinda Nicolau, Geneviève Castonguay, Sreenath Madathil, Thien Vuong, Tahyna Duda Deps Almeida
This article provides an overview of periodontal diseases and traumatic dental injuries (TDIs) in children and adolescents, which are serious public health problems worldwide. Periodontal diseases, including gingivitis and periodontitis, commonly affect the oral soft tissues and teeth and often co-occur with other chronic diseases. TDIs are prevalent from an early age and carry high treatment costs. Behavioral and environmental factors contribute to both TDIs and periodontal diseases, but their etiology varies according to population characteristics and case definition...
October 2018: Pediatric Clinics of North America
Fernanda Ramalho Procopio, Vivian Boesso Oriani, Bruno Nicolau Paulino, Leonardo do Prado-Silva, Glaucia Maria Pastore, Anderson S Sant'Ana, Miriam Dupas Hubinger
Cinnamon bark oleoresin (CO) is a natural flavoring that has several biological properties and can act as an antimicrobial agent. However, oleoresins are susceptible to degradation by light, oxygen and temperature. Thus, the objective of this work was the production and characterization of microparticles loaded with CO obtained by the spray chilling technique. Hardfat (PH) and palm oil (PO) were used as carriers in different proportions: 100:0; 80:20; 60:40, respectively. The active concentration was 1 and 2%...
November 2018: Food Research International
Lindsay M Avery, Joseph L Kuti, Maja Weisser, Adrian Egli, Michael J Rybak, Evan J Zasowski, Cesar A Arias, German A Contreras, Pearlie P Chong, Samuel L Aitken, Adam J DiPippo, Jann-Tay Wang, Nicholas S Britt, David P Nicolau
Background: Currently, there is debate that the daptomycin susceptibility breakpoint (i.e., minimum inhibitory concentration, MIC, ≤4 mg/L) is inappropriate for application to serious enterococcal infections. Observational data support prescription of high doses (>8 mg/kg/day) in the treatment of bacteremia. Pharmacodynamic targets associated with positive patient outcomes, however, remain undefined. Methods: Data were pooled from observational studies assessing outcomes in daptomycin-treated enterococcal bacteremia...
September 5, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
Lindsay M Avery, Kamilia Abdelraouf, David P Nicolau
We evaluated the in vivo efficacy of human-simulated WCK 5222 (cefepime-zidebactam) against cefepime-resistant Acinetobacter baumannii (N=13) in the neutropenic murine lung infection model. Twelve isolates were meropenem-resistant. In control animals and those that received cefepime or zidebactam alone, mean bacterial growth at 24-h was >2 log10 CFU/lung compared with 0-h controls (6.32±0.33 log10 CFU/lung). WCK 5222 produced a decline in bacterial burden for all isolates (mean reduction, -3.34±0.85 log10 CFU/lung) and demonstrated remarkable potency...
September 4, 2018: Antimicrobial Agents and Chemotherapy
Nuria Orribo Morales, Esteban Gonzáles de Cháves Fernández, Balig F Amir Nicolau
The aim of the present study was to evaluate the overall scar satisfaction and quality of life in the conservative surgical treatment of penis cancer with reconstruction according to the Bracka technique. In order to do this, we passed out the questionnaire «Patient Scar Assessment Questionnaire» and the IIEF-15 questionnaire. From 2015 to 2017, 5 conventional glandectomy and reconstruction according to the Bracka technique were performed. 100% of the patients were very satisfied with the result, were slightly aware of the presence of the wound and lacked discomfort in relation to the scar...
August 30, 2018: Revista Internacional de Andrología
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