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Islendy Noreña, Myriam Patricia Pardo, Ismena Mockus
Introduction: The approach to the physiology of pregnancy based on adipokine behavior and the homeostasis-insulin resistance (HOMA-IR) model, along with their relationship to neonatal weight, has been poorly studied in adolescent pregnant women. Objective: To determine possible correlations between adipokines –leptin and adiponectin– and HOMA-IR in pregnant women aged 14 to 17 years, and first-trimester body mass index (BMI) and neonatal weight. Materials and methods: In the weeks 11 to 14 of gestation, the biochemical variables leptin, adiponectin, glycemia and insulin were measured and HOMA-IR was calculated...
September 1, 2018: Biomédica: Revista del Instituto Nacional de Salud
Hoda S Hashemi, Stefanie Fallone, Mathieu Boily, Anna Towers, Robert D Kilgour, Hassan Rivaz
Breast cancer-related lymphedema (BCRL) is a consequence of a malfunctioning lymphatic drainage system resulting from surgery or some other form of treatment. In the initial stages, minor and reversible increases in fluid volume of the arm are evident. As the stages progress over time, the underlying pathophysiology dramatically changes with an irreversible increase in arm volume most likely due to a chronic local inflammation leading to adipose tissue hypertrophy and fibrosis. Clinicians have subjective ways to stage the degree and severity such as the pitting test which entails manually comparing the elasticity of the affected and unaffected arms...
October 15, 2018: IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
M Bennasar, Y A Hicks, S P Clinch, P Jones, C Holt, A Rosser, M Busse
Quantitative assessment of movement impairment in Huntington's disease (HD) is essential to monitoring of disease progression. This paper aimed to develop and validate a novel low cost, objective automated system for the evaluation of upper limb movement impairment in HD in order to eliminate the inconsistency of the assessor and offer a more sensitive, continuous assessment scale. Patients with genetically confirmed HD and healthy controls were recruited to this observational study. Demographic data, including age (years), gender, and unified HD rating scale total motor score (UHDRS-TMS), were recorded...
October 2018: IEEE Transactions on Neural Systems and Rehabilitation Engineering
Pavan K Bhatraju, Leila R Zelnick, Jerald Herting, Ronit Katz, Carmen Mikacenic, Susanna Kosamo, Eric D Morrell, Cassianne Robinson-Cohen, Carolyn S Calfee, Jason D Christie, Kathleen D Liu, Michael A Matthay, William O Hahn, Victoria Dmyterko, Natalie S J Slivinski, Jim A Russell, Keith R Walley, David C Christiani, W Conrad Liles, Jonathan Himmelfarb, Mark M Wurfel
OBJECTIVE: The aim of this study was to identify and test whether AKI sub-phenotypes have prognostic and therapeutic implications. METHODS: First, latent class analysis methodology was applied independently in two critically ill populations (Discovery: n=794 and Replication: n=425) with AKI. Second, a parsimonious classification model was developed to identify AKI sub-phenotypes. Third, the classification model was applied to patients with AKI in the Vasopressin in Septic Shock (VASST: n=271) clinical trial and differences in treatment response were determined...
October 18, 2018: American Journal of Respiratory and Critical Care Medicine
Jeremy A Sabourin, Cheryl D Cropp, Heejong Sung, Lawrence C Brody, Joan E Bailey-Wilson, Alexander F Wilson
Results from association studies are traditionally corroborated by replicating the findings in an independent data set. Although replication studies may be comparable for the main trait or phenotype of interest, it is unlikely that secondary phenotypes will be comparable across studies, making replication problematic. Alternatively, there may simply not be a replication sample available because of the nature or frequency of the phenotype. In these situations, an approach based on complementary pairs stability selection for genome-wide association study (ComPaSS-GWAS), is proposed as an ad-hoc alternative to replication...
October 18, 2018: Genetic Epidemiology
A Bryja, M Dyszkiewicz-Konwińska, Y Huang, P Celichowski, M J Nawrocki, M Jankowski, K Błochowiak, K Mehr, P Ramlau, A Nowicki, D Bukowska, P Antosik, K Osmola, M Bruska, M Zabel, M Nowicki, B Kempisty
Extraordinary abilities for continuous proliferation and differentiation, associated with constant renewal triggered by stimulation from the mastication process, together with the relative lack of aesthetic complications associated with post-surgery healing, have highlighted buccal pouch mucosa as a potential source of explants that could be used in transplantation and tissue engineering. Additionally, this tissue plays a major role in the oral drug delivery process, which brings special interest to its molecular properties in the context of new drug development...
September 2018: Journal of Biological Regulators and Homeostatic Agents
Liuyun Gong, Dan Zhang, Yutiantian Lei, Yuanjie Qian, Xinyue Tan, Suxia Han
AIM: To identify novel candidate genes for pancreatic cancer. METHODS: We performed a transcriptome-wide association study (TWAS) analysis of pancreatic cancer (PC). GWAS summary data were driven from the published studies of PC, totally involving 558 542 SNPs in 1896 individuals with pancreatic cancer and 1939 healthy controls. FUSION software was applied to the PC GWAS summary data for tissue-related TWAS analysis, including whole blood, peripheral blood, adipose, and pancreas...
October 18, 2018: Cancer Medicine
Mona M Savran, Anders Bo Nielsen, Bente Baekholm Poulsen, Poul Bak Thorsen, Lars Konge
BACKGROUND: Hysteroscopy is a technically challenging procedure. Specialty curricula of obstetrics and gynaecology appraise hysteroscopy for trainees but there is no present evidence-based training program that certifies the fundamental technical skills before performance on patients. The objectives of this study were to develop and gather validity evidence for a simulation-based test that can ensure basic competence in hysteroscopy. METHODS: We used the virtual-reality simulator HystMentor™...
October 17, 2018: Surgical Endoscopy
Sherif Dabash, Chris Gerzina, Gautham Prabhakar, Ahmed M Thabet, Soyoung Jeon, Stephen D Heinrich
PURPOSE: Supracondylar fractures in the pediatric population are common. For years, K-wires have been the preferred method of surgical fixation. However, fixation with K-wires alone may lead to multiple complications. This study reports the results of surgical care of supracondylar humerus fractures using screw fixation with K-wires or screw fixation alone. METHODS: This study retrospectively reviewed all patients with supracondylar humerus fractures treated with screw fixation between 2007 and 2013...
October 17, 2018: European Journal of Orthopaedic Surgery & Traumatology: Orthopédie Traumatologie
Frank Koopmans, Nikhil J Pandya, Sigrid K Franke, Ingrid H C M H Phillippens, Iryna Paliukhovich, Ka Wan Li, August B Smit
Key to the human brain's unique capacities are a myriad of neural cell types, specialized molecular expression signatures, and complex patterns of neuronal connectivity. Neurons in the human brain communicate via well over a quadrillion synapses. Their specific contribution might be key to the dynamic activity patterns that underlie primate-specific cognitive function. Recently, functional differences were described in transmission capabilities of human and rat synapses. To test whether unique expression signatures of synaptic proteins are at the basis of this, we performed a quantitative analysis of the hippocampal synaptic proteome of four mammalian species, two primates, human and marmoset, and two rodents, rat and mouse...
2018: Frontiers in Molecular Neuroscience
Cesare Brandi, Roberto Cuomo, Giuseppe Nisi, Luca Grimaldi, Carlo D'Aniello
INTRODUCTION: The slowing of the aging process is subject of great research and attention in modern society, particularly aging of face. Processes involved are very complex. Mesotherapy. hyaluronic acid and carbon dioxide injection can be used for biorevitalization and skin rejuvenation. METHODS: Three groups were made and 62 patients were enrolled. Patients with superficial wrinkles of the face, neck and/or décolleté, without presence of nasolabial folds and marionette wrinkles were included in group 1...
October 8, 2018: Acta Bio-medica: Atenei Parmensis
Morteza Safi, Mohammad Ali Mehrabi, Saeed Alipour Parsa, Isa Khaheshi, Mohammadreza Naderian
BACKGROUND AND AIM: Applying fractional flow reserve (FFR) recently helped to assess borderline coronary defects and also facilitates assessment of these lesions. The present study aimed to assess cost-effectiveness of FFR in detection of these borderline lesions. METHODS: This cross-sectional study was conducted on140 consecutive patients with 219 diseased arteries who underwent coronary angiography and suffered intermediate coronary lesions. RESULTS: Of 18 patients who candidate for CABG before FFR, only one patient underwent CABG after determining FFR (P-value<0...
October 8, 2018: Acta Bio-medica: Atenei Parmensis
Claudio Costantino, Gianmarco Ventura, Claudia Marotta, Stefania Enza Bono, Evelina Arcidiacono, Carlo Roberto Gambino, Maurizio Gentile, Sara Palmeri, Giovanna Ripoli, Claudia Emilia Sannasardo, Pierfrancesco Sannasardo, Francesco Scarpitta, Carlotta Vella, Walter Mazzucco, Alessandra Casuccio, Vincenzo Restivo
BACKGROUND AND AIM OF THE WORK: Bullying involves a significant percentage of school-age children. According to the latest available surveillance data, in Sicily, the estimated prevalence among 11-15 years old children is 14%. This study aimed to estimate a prevalence of the bullying phenomenon, observed by teachers, in a sample of secondary schools of Palermo, Sicily. Moreover, after the conduction of preventive interventions among teachers, aimed to evaluate any modification in bullying prevalence...
October 8, 2018: Acta Bio-medica: Atenei Parmensis
Tongwu Zhang, Jiyeon Choi, Michael A Kovacs, Jianxin Shi, Mai Xu, Alisa M Goldstein, Adam J Trower, D Timothy Bishop, Mark M Iles, David L Duffy, Stuart MacGregor, Laufey T Amundadottir, Matthew H Law, Stacie K Loftus, William J Pavan, Kevin M Brown
Most expression quantitative trait locus (eQTL) studies to date have been performed in heterogeneous tissues as opposed to specific cell types. To better understand the cell-type-specific regulatory landscape of human melanocytes, which give rise to melanoma but account for <5% of typical human skin biopsies, we performed an eQTL analysis in primary melanocyte cultures from 106 newborn males. We identified 597,335 cis -eQTL SNPs prior to linkage disequilibrium (LD) pruning and 4997 eGenes (FDR < 0.05)...
October 17, 2018: Genome Research
Lorena Cussó, Manuel Desco
INTRODUCTION: Retention of 2-deoxy-2-[18F]fluoro-D-glucose 18F-FDG in the bladder causes more problems in small animal research than in human research owing to the smaller size of the subject. Catheterization has been proposed to reduce bladder spillover both in human studies and in small animal research. Noninvasive alternatives such as hydration plus furosemide also seem to be a promising pre-imaging strategy for decreasing bladder spillover. Our main goal was to measure the effects of the combination of furosemide and hydration for reducing bladder signal directly on mouse bowel 18F-FDG-PET images...
2018: PloS One
Ernesto Quaresma Mendonça, Fernanda Cristina Simões Pessorrusso, Marcus Fernando Kodama Pertille Ramos, Carlos Eduardo Jacob, Joel Fernandez de Oliveira, Maria Sylvia Ribeiro, Adriana Safatle-Ribeiro, Bruno Zilberstein, Ulysses Ribeiro Júnior, Fauze Maluf-Filho
OBJECTIVE: Our aim was to evaluate the Japan Gastroenterological Endoscopy Society criteria for endoscopic submucosal resection of early gastric cancer (EGC) based on the experience in a Brazilian cancer center. METHODS: We included all patients who underwent endoscopic submucosal resection for gastric lesions between February 2009 and October 2016. Demographic data and information regarding the endoscopic resection, pathological report and follow-up were obtained...
October 11, 2018: Clinics
Thaís da Silva Ferreira, Julia Freitas Rodrigues Fernandes, Luciene da Silva Araújo, Lívia de Paula Nogueira, Priscila Mansur Leal, Vanessa Parada Antunes, Maria de Lourdes Guimarães Rodrigues, Debora Cristina Torres Valença, Sergio Emanuel Kaiser, Márcia Regina Simas Torres Klein
BACKGROUND: Observational studies have highlighted an association between serum uric acid (SUA) levels and cardiovascular risk factors. Despite the growing body of evidences, several studies were conducted in older individuals or in carriers of diseases susceptible to affect SUA levels and cardiometabolic risk markers. OBJECTIVE: To evaluate the relationship of SUA with body adiposity, metabolic profile, oxidative stress, inflammatory biomarkers, blood pressure and endothelial function in healthy young and middle-aged adults...
October 11, 2018: Arquivos Brasileiros de Cardiologia
Lien Desteghe, Lara Engelhard, Johan Vijgen, Pieter Koopman, Dagmara Dilling-Boer, Joris Schurmans, Michiel Delesie, Paul Dendale, Hein Heidbuchel
BACKGROUND: The knowledge level of atrial fibrillation patients about their arrhythmia, its consequences and treatment is poor. The best strategy to provide education is unknown. AIM: To investigate the effect of reinforced targeted in-person education using the Jessa Atrial fibrillation Knowledge Questionnaire (JAKQ). METHODS: Sixty-seven atrial fibrillation patients were randomized to standard care (including brochures) or targeted education...
October 17, 2018: European Journal of Cardiovascular Nursing
Hadise Aslfalah, Mehri Jamilian, Fatemeh Rafiei, Ali Khosrowbeygi
AIM: Alpha-lipoic acid (ALA) is a short chain fatty acid which has a key role in energy production. ALA is also known as a universal antioxidant. The aim of the present study was to explore the effects of ALA supplementation in women with gestational diabetes mellitus. METHODS: A randomized double-blind placebo-controlled clinical trial study was designed. Women with gestational diabetes mellitus (n = 60) during 24-28 weeks of gestation were selected and divided randomly into drug (n = 30) and placebo (n = 30) groups...
October 16, 2018: Journal of Obstetrics and Gynaecology Research
Eshetu Andarge, Yohannes Shiferaw
Intimate partner violence (IPV) against women and food insecurity are an ever growing public health concerns in Ethiopia. However, the connection between the two is not yet well investigated. Therefore, this study compares IPV by household food security status and examines the association between IPV and food insecurity and among currently married women in childbearing age in Arba Minch town, South Ethiopia. A community based comparative cross-sectional study was conducted among 696 currently married women (15-49)...
2018: BioMed Research International
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