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Jiang Zhu, Zhao Xue, Shumei Zhang, Xinxin Guo, Laihui Zhai, Shipeng Shang, Yan Zhang, Haibo Lu
BACKGROUND: The lymph node ratio (LNR) as a prognostic parameter for gastric cancer has yet to be fully validated in the current tumor node metastasis staging system. We assessed the prognostic role of LNR in lymph node-positive gastric cancer through a meta-analysis. MATERIALS AND METHODS: PubMed and EMBASE were searched for relevant studies up until December 2016. The effect measure for meta-analysis of primary outcomes was the hazard ratio (HR) for overall survival...
August 10, 2018: International Journal of Surgery
Ioanna Anastopoulou, Fotios A Karakostis, Konstantinos Moraitis
Accurate sorting of commingled human remains comprises a fundamental requirement for all further anthropological analyses. The lower limb bones are particularly important for reconstructing biological profiles. This study introduces a metric technique for sorting these elements using eight standard anthropological measurements and 222 adult individuals from Greece. The bones utilized were the os coxae, the femora, the tibiae and the tali. Simple regression analyses were used to develop functions for reassociating articulating bones, providing strong correlations (r = 0...
August 13, 2018: Journal of Forensic Sciences
Rong Zhang, Zhao Ren, Wei Chen
Gene co-expression network analysis is extremely useful in interpreting a complex biological process. The recent droplet-based single-cell technology is able to generate much larger gene expression data routinely with thousands of samples and tens of thousands of genes. To analyze such a large-scale gene-gene network, remarkable progress has been made in rigorous statistical inference of high-dimensional Gaussian graphical model (GGM). These approaches provide a formal confidence interval or a p-value rather than only a single point estimator for conditional dependence of a gene pair and are more desirable for identifying reliable gene networks...
August 13, 2018: PLoS Computational Biology
Megumi Hara, Tsuyoshi Hachiya, Yoichi Sutoh, Keitaro Matsuo, Yuichiro Nishida, Chisato Shimanoe, Keitaro Tanaka, Atsushi Shimizu, Keizo Ohnaka, Takahisa Kawaguchi, Isao Oze, Fumihiko Matsuda, Hidemi Ito, Sayo Kawai, Asahi Hishida, Rieko Okada, Tae Sasakabe, Akie Hirata, Rie Ibusuki, Yora Nindita, Norihiro Furusyo, Hiroaki Ikezaki, Nagato Kuriyama, Etsuko Ozaki, Haruo Mikami, Yohko Nakamura, Sadao Suzuki, Akihiro Hosono, Sakurako Katsuura-Kamano, Kokichi Arisawa, Kiyonori Kuriki, Kaori Endoh, Naoyuki Takashima, Aya Kadota, Masahiro Nakatochi, Yukihide Momozawa, Michiaki Kubo, Mariko Naito, Kenji Wakai
PURPOSE: Although several genetic factors may play a role in leisure-time exercise behavior, there is currently no evidence of a significant genome-wide association, and candidate gene replication studies have produced inconsistent results. METHODS: We conducted a two-stage genome-wide association study (GWAS) and candidate single nucleotide polymorphisms (SNPs) association study on leisure-time exercise behavior using 13,980 discovery samples from the Japan Multi-Institutional Collaborative Cohort (J-MICC) study, and 2,036 replication samples from the Hospital-based Epidemiologic Research Program at Aichi Cancer Center-2 (HERPACC-2) study...
August 10, 2018: Medicine and Science in Sports and Exercise
Masaru Hiki, Takatoshi Kasai, Shoichiro Yatsu, Azusa Murata, Hiroki Matsumoto, Takao Kato, Shoko Suda, Tetsuro Miyazaki, Atsutoshi Takagi, Hiroyuki Daida
Although hyponatremia during hospitalization for acute decompensated heart failure (ADHF) is reportedly related with poor prognosis, the available data regarding the impact of serum sodium level within the low-normal range at admission on clinical events in patients with ADHF is limited.We studied eligible patients admitted to our institution in 2007-2011. All the patients were categorized into 3 groups according to the admission serum sodium levels of < 135 mmol/L (hyponatremia), ≥ 135 and < 140 mmol/L (low-normal range), or ≥ 140 mmol/L (normal range)...
August 11, 2018: International Heart Journal
Stuart B Murray, Daniel S Quintana, Katharine L Loeb, Scott Griffiths, Daniel Le Grange
BACKGROUND: To determine the impact of specialized treatments, relative to comparator treatments, upon the weight and psychological symptoms of anorexia nervosa (AN) at end-of-treatment (EOT) and follow-up. METHODS: Randomized controlled trials (RCTs) between January 1980 and December 2017 that reported the effects of at least two treatments on AN were screened. Weight and psychological symptoms were analyzed separately for each study. PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines were followed, and studies were assessed using the GRADE (Grading of Recommendations, Assessment, Development and Evaluation) criteria and Cochrane risk of bias tool...
August 13, 2018: Psychological Medicine
Miaoxin Li, Lin Jiang, Timothy Shin Heng Mak, Johnny Sheung Him Kwan, Chao Xue, Peikai Chen, Henry Chi-Ming Leung, Liqian Cui, Tao Li, Pak Chung Sham
Motivation: It remains challenging to unravel new susceptibility genes of complex diseases and the mechanisms in genome-wide association studies. There are at least two difficulties, isolation of the genuine susceptibility genes from many indirectly associated genes and functional validation of these genes. Results: We first proposed a novel conditional gene-based association test which can use only summary statistics to isolate independent association genes of a disease...
August 7, 2018: Bioinformatics
Ayalew Assefa
Leishmaniasis is a neglected tropical disease caused by obligate intracellular protozoa of the genus Leishmania . Ethiopia does not have an overall estimation of prevalence of leishmaniasis infection at a country level. The objective of this systematic review and meta-analysis was to summarize and pool estimates of studies that report the prevalence of leishmaniasis in Ethiopia. The literature search was conducted to identify all published studies reporting the prevalence of leishmaniasis with clearly designed inclusion and exclusion criteria...
August 2018: Heliyon
Seza Tetikkurt, Elif Çelik, Hazal Taş, Tuğçe Cay, Selman Işik, Abdullah Taner Usta
The present study was conducted to identify endometrial and myometrial lesions coexisting with adenomyosis, and to evaluate the clinicopathological characteristics of endometrial adenocarcinomas associated with adenomyosis. A retrospective analysis of the resected uterine specimens of 319 patients with adenomyosis admitted between January 1, 2014 and August 1, 2017 was performed. The endometrial and myometrial lesions coexisting with adenomyosis were evaluated. The clinicopathological prognostic factors, including tumor grade, myometrial invasion, lymphovascular space involvement, lymph node invasion, pathological stage and recurrence, were analysed...
August 2018: Molecular and Clinical Oncology
Moses Katbi, Adeoye Adegboye, Adefisayo Adedoyin, Fadimatu Yunusa, Gbenga Kayode, Maryam Bello, Patrick Dakum
BACKGROUND: Strategic Index Case Testing (STRICT), a form of partner notification service, was initiated to track, identify and notify sexual partners of people living with HIV (Index clients) with the sole aim of testing them to determine their HIV status and linking clients who are positive to Anti-Retroviral Therapy (ART). This research analyzed the HIV sero-prevalence among sexual partners of HIV positive clients using STRICT and determines the role of STRICT in HIV epidemic control...
July 7, 2018: International Journal of Infectious Diseases: IJID
Wasithep Limvorapitak, Michael J Barnett, Donna E Hogge, Donna L Forrest, Thomas J Nevill, Sujaatha Narayanan, Maryse M Power, Stephen H Nantel, Raewyn Broady, Kevin W Song, Cynthia L Toze, Yasser Abou Mourad, Heather J Sutherland, Alina S Gerrie, Jennifer White, David S Sanford
INTRODUCTION: Optimal post-remission therapy (PRT) for intermediate risk acute myeloid leukemia remains an area of ongoing research. We aimed to retrospectively compare outcomes following autologous stem cell transplantation (autoSCT) with allogeneic SCT (alloSCT) and consolidation chemotherapy (CMT) in patients with intermediate-risk karyotype AML in first complete remission. PATIENTS AND METHODS: We compared overall survival (OS) and leukemia-free survival (LFS) using propensity score (PS)-adjusted analysis of patients receiving PRT with autoSCT, matched sibling (MSD) alloSCT, unrelated/mismatch (UD/MM) alloSCT, and CMT...
July 17, 2018: Clinical Lymphoma, Myeloma & Leukemia
Ana Christina Certain Curi, Alex Souto Maior Alves, Julio Guilherme Silva
OBJECTIVE: The aim of this study was to compare blood pressure (BP) behavior and heart rate variability (HRV) among hypertensive stage I and normotensive individuals who were submitted to the cranial technique of the 4th ventricle compression (CV4), an osteopathic technique. METHODS: In this experimental controlled study, thirty men between 40 and 60 years old were evaluated and divided into two groups: normotensive (NT) and hypertensive (HT). The CV4 maneuver was applied in both groups and BP was measured at 5 (five) different stages: pre and post-intervention, 5, 10 and 15min after technique...
July 2018: Journal of Bodywork and Movement Therapies
Byoungjin Park, Yong-Jae Lee
BACKGROUND: Metabolic syndrome (MetS) is clinically important because of its association with increased risk of sudden cardiac death, as well as cardiovascular disease-related mortality. Data between MetS and prolonged corrected QT (QTc) intervals, a useful predictor of sudden cardiac death, are limited in apparently healthy adults. OBJECTIVE: This study determined the association between MetS and QTc interval in apparently healthy Korean men and women. METHODS: We examined the association between MetS and QTc interval in 2157 Korean adults (1317 men and 840 women) in a health examination program but excluded participants with a history of ischemic heart disease, stroke, cardiac arrhythmia, cancer, thyroid, respiratory, renal, hepatobiliary, or rheumatologic disease...
July 20, 2018: Journal of Clinical Lipidology
Alexander Bonde, Rasmus Kirial, Peter Svenningsen, Martin Sillesen
BACKGROUND: Despite initial lifesaving benefits, posttraumatic resuscitation strategies have been associated with immunologic complications leading to systemic inflammatory response syndrome, sepsis, multiple organ failure, and late trauma death. Nevertheless, the direct effect on immunologic surface markers remains inadequately described. We hypothesized that changes in monocyte and T-cell surface markers were associated with initial posttraumatic fluid resuscitation. MATERIALS AND METHODS: Data were extracted from the inflammation and host response to injury (Glue Grant) study...
October 2018: Journal of Surgical Research
Michelle Pavlick, Cynthia Rl Webster, Dominique G Penninck
Objectives Liver biopsy is necessary for a diagnosis of liver disease; however, post-biopsy bleeding is a concern. The aim of this study was to describe the extent of bleeding and the occurrence of complications after percutaneous ultrasound-guided liver biopsy (PUGLB) in cats. Methods The medical records of 30 cats that had a PUGLB were retrospectively reviewed. Using human guidelines, bleeding was classified as minor or major when the absolute change in packed cell volume (ΔPCV) was >0 and <-6% or ≥-6%, respectively...
August 13, 2018: Journal of Feline Medicine and Surgery
Hani Oweira, Omar Abdel-Rahman, Anwar Giryes, Meinrad Mannhart, Michael Decker
BACKGROUND: Time to start adjuvant therapy has been shown to be an important determinant of survival following curative resection of colorectal cancer. Time to start systemic therapy following diagnosis of metastatic colorectal cancer (mCRC) needs to be additionally studied and assessed. METHODS: This is a pooled analysis of the raw data of the comparator arms of two randomized studies (NCT00272051; NCT00305188). Univariate and Multivariate analysis of predictors of overall and progression-free survival was conducted through Cox regression analysis...
August 11, 2018: Expert Review of Gastroenterology & Hepatology
C Mary Schooling, S Luo, G Johnson
BACKGROUND: Despite great progress in the prevention and control of cardiovascular disease, it remains the leading cause of global mortality and morbidity, with new unexpected risk factors emerging and few effective new pharmaceutical treatments. ADAMTS-13 is involved in a clotting disorder, thrombotic thrombocytopenic purpura, for which new treatments are being developed. Observationally, ADAMTS-13 activity is inversely associated with ischemic heart disease (IHD) but positively associated with diabetes...
August 12, 2018: Journal of Thrombosis and Haemostasis: JTH
Olufemi Gbenga Omitola, Olujide Oladele Soyele, Azeez Butali, Abdulwarith Olaitan Akinshipo, Dickson Okoh, Opeyemi Sigbeku, Olajumoke Ajibola Effiom, Kehinde Emmanuel Adebiyi, Adeola Mofolouwake Ladeji, Akinyele Olumuyiwa Adisa, Ahmed Oluwatoyin Lawal, Osareniye Osayande, Ramat Oyebunmi Braimah, Henry Ademola Adeola
OBJECTIVES: Accurate diagnosis of salivary gland neoplasms (SGN) in many centres in Africa is limited by poor diagnostic resources and ancillary services. Hence, we have carried out a multi-centre epidemiological study to understand the true burden of SGN in Nigeria. METHOD: In this descriptive cross-sectional study, we have deployed resources available to members of the African Oral Pathology consortium (AOPRC) to examine the burden of Salivary gland lesions in Nigeria, using a multi-centre approach...
August 12, 2018: Oral Diseases
Julphat Intarasupht, Anchisa Kanchanomai, Wuttirak Leelasattakul, Thoranis Chantrarat, Artit Nakakes, Waraporn Tiyanon
BACKGROUND: Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome is a severe cutaneous drug reaction that can affect multiple internal organ systems. Cardiac involvement in DRESS syndrome (CiDs) is uncommon but can be life-threatening. OBJECTIVE: To determine the prevalence, risk factors, and mortality outcome of CiDs. MATERIAL AND METHODS: Forty-one patients who were diagnosed with probable and definite DRESS syndrome according to the RegiSCAR criteria were recruited...
August 11, 2018: International Journal of Dermatology
Qian Wang, Ya-Ming Li, Yuan Li, Feng-Chun Hua, Quan-Shi Wang, Xiao-Li Zhang, Chao Cheng, Hua Wu, Zhi-Ming Yao, Wei-Fang Zhang, Qing-Yi Hou, Wei-Bing Miao, Xue-Mei Wang
PURPOSE: To evaluate the clinical value of 18 F-FDG-PET/CT for the diagnosis of fever of unknown origin (FUO) and inflammation of unknown origin (IUO) in Chinese population, as well as the characteristics of PET/CT in different category of etiological disease. METHODS: A total of 376 consecutive patients with FUO/IUO who underwent FDG-PET/CT at 12 hospitals were retrospectively studied. FDG uptake was quantitatively and visually evaluated, by using SUVmax and a 4-grade scale respectively...
August 11, 2018: European Journal of Nuclear Medicine and Molecular Imaging
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