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https://www.readbyqxmd.com/read/30480086/risk-factors-of-levodopa-induced-dyskinesia-in-parkinson-s-disease-results-from-the-ppmi-cohort
#1
Paolo Eusebi, Michele Romoli, Federico Paolini Paoletti, Nicola Tambasco, Paolo Calabresi, Lucilla Parnetti
Levodopa-induced dyskinesias (LID) negatively impact on the quality of life of patients with Parkinson's disease (PD). We assessed the risk factors for LID in a cohort of de-novo PD patients enrolled in the Parkinson's Progression Markers Initiative (PPMI). This retrospective cohort study included all PD patients enrolled in the PPMI cohort. Main outcome was the incidence rate of dyskinesia, defined as the first time the patient reported a non-zero score in the item "Time spent with dyskinesia" of the MDS-UPDRS part IV...
2018: NPJ Parkinson's Disease
https://www.readbyqxmd.com/read/30473193/neuroimaging-applications-in-chronic-ataxias
#2
Mario Mascalchi, Alessandra Vella
Magnetic resonance imaging (MRI), single photon emission computed tomography (SPECT) and positron emission tomography (PET) are the main instruments for neuroimaging investigation of patients with chronic ataxia. MRI has a predominant diagnostic role in the single patient, based on the visual detection of three patterns of atrophy, namely, spinal atrophy, cortical cerebellar atrophy and olivopontocerebellar atrophy, which correlate with the aetiologies of inherited or sporadic ataxia. In fact spinal atrophy is observed in Friedreich ataxia, cortical cerebellar atrophy in Ataxia Telangectasia, gluten ataxia and Sporadic Adult Onset Ataxia and olivopontocerebellar atrophy in Multiple System Atrophy cerebellar type...
2018: International Review of Neurobiology
https://www.readbyqxmd.com/read/30464029/developing-and-validating-parkinson-s-disease-subtypes-and-their-motor-and-cognitive-progression
#3
Michael Lawton, Yoav Ben-Shlomo, Margaret T May, Fahd Baig, Thomas R Barber, Johannes C Klein, Diane M A Swallow, Naveed Malek, Katherine A Grosset, Nin Bajaj, Roger A Barker, Nigel Williams, David J Burn, Thomas Foltynie, Huw R Morris, Nicholas W Wood, Donald G Grosset, Michele T M Hu
OBJECTIVES: To use a data-driven approach to determine the existence and natural history of subtypes of Parkinson's disease (PD) using two large independent cohorts of patients newly diagnosed with this condition. METHODS: 1601 and 944 patients with idiopathic PD, from Tracking Parkinson's and Discovery cohorts, respectively, were evaluated in motor, cognitive and non-motor domains at the baseline assessment. Patients were recently diagnosed at entry (within 3...
December 2018: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/30416409/the-prevalence-of-cerebral-microbleeds-in-non-demented-parkinson-s-disease-patients
#4
Kyeong Joon Kim, Yun Jung Bae, Jong-Min Kim, Beom Joon Kim, Eung Seok Oh, Ji Young Yun, Ji Seon Kim, Han-Joon Kim
Background: Cerebral microbleeds (CMBs) are associated with cerebrovascular risk factors and cognitive dysfunction among patients with Parkinson's disease (PD). However, whether CMBs themselves are associated with PD is to be elucidated. Methods: We analyzed the presence of CMBs using 3-Tesla brain magnetic resonance imaging in non-demented patients with PD and in age-, sex-, and hypertension-matched control subjects. PD patients were classified according to their motor subtypes: tremor-dominant, intermediate, and postural instability-gait disturbance (PIGD)...
November 12, 2018: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/30416335/evaluation-of-dysphagia-in-different-phenotypes-of-early-and-idiopathic-parkinsonism
#5
Al-Amir Bassiouny Mohamed, Gharib Fawi Mohamed, Hassan Mohamed Elnady, Mohamed Abdelmoneim Sayed, Ahmed Mamdouh Imam, Megahed Mohamed Hassan, Sherihan Rezk Ahmed
Background: Parkinsonism (PD) is a common neurodegenerative disorders into which dysphagia occurs mainly in the late stage and to a lesser extent in an early stage. Diagnosis of dysphagia particularly in early idiopathic Parkinson's disease (IPD) is important as dysphagia affects the quality of life of patients and most of the patients are unaware of this important symptom. Method: Fifty-four patients were enrolled in this study presented with early IPD attending to the outpatient clinic of Sohag University Hospital...
2018: The Egyptian journal of neurology, psychiatry and neurosurgery
https://www.readbyqxmd.com/read/30363072/clinical-characterization-of-genetically-diagnosed-cases-of-spinocerebellar-ataxia-type-12-from-india
#6
Supriyo Choudhury, Sayan Chatterjee, Koustav Chatterjee, Rebecca Banerjee, Jonathan Humby, Banashree Mondal, Sidharth S Anand, Shantanu Shubham, Hrishikesh Kumar
https://onlinelibrary.wiley.com/page/journal/23301619/homepage/mdc312551-sup-v001_1.htm. Background: Spinocerebellar ataxia type 12 (SCA12) is a rare form of an autosomal-dominant ataxic disorder associated with an expansion of CAG repeat length. Here, we present a large case series of patients with SCA12 and describe a wide range of typical and rare symptoms. Methods: Twenty-one consecutive patients with genetically proven SCA12 underwent detailed neurological examination...
January 2018: Movement Disorders Clinical Practice
https://www.readbyqxmd.com/read/30346434/-parkinson-s-disease-and-glutamate-excitotoxicity
#7
Yu S Mironova, I A Zhukova, N G Zhukova, V M Alifirova, O P Izhboldina, A V Latypova
AIM: To measure the concentration of glutamate in the serum of patients with Parkinson's disease (PD) and determine its association with clinical variants of disease course. MATERIAL AND METHODS: One hundred and ten patients with PD and 90 healthy people were examined. Glutamate concentration in the blood serum was determined with a spectrophotometric method. RESULTS AND CONCLUSION: Patients with Parkinson's disease had significantly higher levels of serum glutamate compared with healthy subjects (p<0,0001)...
2018: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/30337863/parkinson-s-disease-motor-subtypes-show-different-responses-to-long-term-subthalamic-nucleus-stimulation
#8
Cuiping Xu, Ping Zhuang, Mark Hallett, Yuqing Zhang, Jianyu Li, Yongjie Li
Background and purpose: Subthalamic nucleus deep brain stimulation (STN DBS) is well established for the treatment of advanced Parkinson's disease (PD), substantially improving motor symptoms, quality of life, and reducing the long-term need for dopaminergic medication. However, whether chronic STN DBS produces different effects on PD motor subtypes is unknown. This retrospective study aimed to evaluate the long-term effects of STN DBS on the PD motor subtypes. Methods: Eighty patients undergoing STN DBS were included...
2018: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/30321795/resting-state-network-connectivity-in-cognitively-unimpaired-drug-na%C3%A3-ve-patients-with-rigidity-dominant-parkinson-s-disease
#9
Yanbing Hou, Jing Yang, Chunyan Luo, Ruwei Ou, Yutong Zou, Wei Song, Qiyong Gong, Huifang Shang
BACKGROUND: Parkinson's disease (PD) could be classified into akinetic-rigidity (PDAR ), tremor-dominant (PDTD ) and mixed subtypes. PDAR patients are more prone to develop cognitive deficits. The default mode network (DMN), fronto-parietal network (FPN) and dorsal attention network (DAN) play important roles in cognitive processing. Our aim was to evaluate changes in connectivity patterns of the DMN, and its interrelation with the FPN and DAN in cognitively unimpaired drug-naïve PDAR patients...
October 3, 2018: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/30319535/beyond-dopamine-gaba-glutamate-and-the-axial-symptoms-of-parkinson-disease
#10
Ruth L O'Gorman Tuura, Christian R Baumann, Heide Baumann-Vogel
Introduction: The axial symptoms of Parkinson disease (PD) include difficulties with balance, posture, speech, swallowing, and locomotion with freezing of gait, as well as axial rigidity. These axial symptoms impact negatively on quality of life for many patients, yet remain poorly understood. Dopaminergic treatments typically have little effect on the axial symptoms of PD, suggesting that disruptions in other neurotransmitter systems beyond the dopamine system may underlie these symptoms. The purpose of the present study was to examine the relationship between the axial symptoms of PD and GABA and glutamate levels quantified with magnetic resonance spectroscopy...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/30297519/cognitive-decline-in-parkinson-s-disease-the-impact-of-the-motor-phenotype-on-cognition
#11
Jennifer Wojtala, Ines Ann Heber, Petra Neuser, Julia Heller, Elke Kalbe, Sarah P Rehberg, Alexander Storch, Katharina Linse, Christine Schneider, Susanne Gräber, Daniela Berg, Judith Dams, Monika Balzer-Geldsetzer, Rüdiger Hilker-Roggendorf, Carola Oberschmidt, Simon Baudrexel, Karsten Witt, Nele Schmidt, Günther Deuschl, Brit Mollenhauer, Claudia Trenkwalder, Inga Liepelt-Scarfone, Annika Spottke, Sandra Roeske, Ullrich Wüllner, Hans-Ulrich Wittchen, Oliver Riedel, Richard Dodel, Jörg B Schulz, Kathrin Reetz
OBJECTIVES: Parkinson's disease (PD) is the second most common neurodegenerative disorder and is further associated with progressive cognitive decline. In respect to motor phenotype, there is some evidence that akinetic-rigid PD is associated with a faster rate of cognitive decline in general and a greater risk of developing dementia.The objective of this study was to examine cognitive profiles among patients with PD by motor phenotypes and its relation to cognitive function. METHODS: Demographic, clinical and neuropsychological cross-sectional baseline data of the DEMPARK/LANDSCAPE study, a multicentre longitudinal cohort study of 538 patients with PD were analysed, stratified by motor phenotype and cognitive syndrome...
October 8, 2018: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/30288794/magnetic-resonance-guided-focused-ultrasound-thalamotomy-for-treatment-of-essential-tremor-a-2-year-outcome-study
#12
Ying Meng, Benjamin Solomon, Alexandre Boutet, Maheleth Llinas, Nadia Scantlebury, Yuexi Huang, Kullervo Hynynen, Clement Hamani, Alfonso Fasano, Andres M Lozano, Nir Lipsman, Michael L Schwartz
BACKGROUND: Magnetic resonance-guided focused ultrasound is an emerging, minimally invasive thermoablation technique for medically refractory essential tremor. Beyond the initial year, data regarding efficacy and potential predictors of efficacy are still preliminary. OBJECTIVES: The objective of this study was to assess the outcome at 2 years and the association between lesion volume and outcome 1 year after treatment. METHODS: We reviewed data from 37 patients who underwent unilateral magnetic resonance-guided focused ultrasound thalamotomy, with primary outcome being dominant tremor subscore of the Clinical Rating Scale for Tremor...
October 2018: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/30244415/patterns-of-striatal-and-cerebellar-functional-connectivity-in-early-stage-drug-na%C3%A3-ve-patients-with-parkinson-s-disease-subtypes
#13
Yanbing Hou, Ruwei Ou, Jing Yang, Wei Song, Qiyong Gong, Huifang Shang
PURPOSE: Both the striatal-thalamo-cortical (STC) circuit and cerebello-thalamo-cortical (CTC) circuit play a critical role in Parkinson's disease (PD). METHODS: Resting-state functional MRI was used to assess functional connectivity (FC) focusing on the basal ganglia (BG) and cerebellum among early-stage drug-naïve PD patients with tremor-dominant (TD) PD patients with postural instability and gait dysfunction (PIGD) and healthy controls (HCs). RESULTS: Compared to HCs, both PD subgroups had higher FC between the cerebellum and paracentral lobule, sensorimotor areas; lower FC between the BG and superior frontal gyrus, and within the BG circuit; PD-TD patients showed higher FC between the BG and fusiform, paracentral lobule, cerebellum Lobule VI, and between the cerebellum and supplementary motor areas (SMA), insula; lower FC between the BG and rectus, sensorimotor areas, and within the cerebellum circuit; PD-PIGD patients showed higher FC between the cerebellum and middle frontal gyrus, precuneus; lower FC between the BG and cerebellum Crus II...
December 2018: Neuroradiology
https://www.readbyqxmd.com/read/30227440/combined-unilateral-posteroventral-pallidotomy-and-ventral-intermediate-nucleus-thalamotomy-in-tremor-dominant-parkinson-apos-s-disease-versus-posteroventral-pallidotomy-alone-a-prospective-comparative-study
#14
Zeiad Y Fayed, Hesham Radwan, Mohamed Aziz, Mohamed Eid, Alia H Mansour, Mohamed Nosseir, Hisham Anwer, Tarek Elserry, Walid A Abdel Ghany
BACKGROUND: The optimum target in surgery for Parkinson's disease (PD) is still controversial, especially in patients with tremor-dominant PD. We aim to compare results in tremor-dominant patients undergoing pallidotomy vs. those undergoing simultaneous posteroventral pallidotomy (PVP) and ventral intermediate nucleus (VIM) thalamotomy. METHODS: Twenty-four patients with tremor-dominant PD were included in this study. Twelve patients received unilateral PVP contralateral to the most affected side...
2018: Stereotactic and Functional Neurosurgery
https://www.readbyqxmd.com/read/30186307/assessment-of-molecular-measures-in-non-fxtas-male-premutation-carriers
#15
Reem R Al Olaby, Hiu-Tung Tang, Blythe Durbin-Johnson, Andrea Schneider, David Hessl, Susan M Rivera, Flora Tassone
Approximately 30-40% of male and 8-16% of female carriers of the Fragile X premutation will develop a neurodegenerative movement disorder characterized by intentional tremor, gait ataxia, autonomic dysfunction, cognitive decline, and Parkinsonism during their lifetime. At the molecular level, premutation carriers have increased expression levels of the FMR1 and the antisense FMR1 ( ASFMR1) mRNAs. Both genes undergo alternative splicing giving rise to a number of different transcripts. Alteration in the alternative splicing process might be associated with FXTAS...
2018: Frontiers in Genetics
https://www.readbyqxmd.com/read/30160376/psychiatric-profile-of-motor-subtypes-of-de-novo-drug-na%C3%A3-ve-parkinson-s-disease-patients
#16
Francesca Assogna, Clelia Pellicano, Luca Cravello, Cinzia Savini, Mariangela Pierantozzi, Bruno Mercuri, Carlo Caltagirone, Francesco E Pontieri, Gianfranco Spalletta, Alessandro Stefani
BACKGROUND: Parkinson's disease (PD) is a heterogeneous neurodegenerative disorder. It is well established that different motor subtypes of PD evolve with different clinical courses and prognoses. The complete psychiatric profile underlying these different phenotypes since the very early stage of the disease is debated. AIMS OF THE STUDY: We aimed at investigating the psychiatric profile of the three motor subtypes of PD (akinetic-rigid, tremor-dominant, and mixed) in de novo drug-naïve patients with PD...
October 2018: Brain and Behavior
https://www.readbyqxmd.com/read/30158164/mrigfus-in-tremor-dominant-pd-does-not-lead-to-substantial-cognitive-adverse-events
#17
EDITORIAL
Thomas M Zervos, Clement Hamani, Jason M Schwalb
No abstract text is available yet for this article.
October 2, 2018: Neurology
https://www.readbyqxmd.com/read/30158160/focused-ultrasound-thalamotomy-in-parkinson-disease-nonmotor-outcomes-and-quality-of-life
#18
Scott A Sperling, Binit B Shah, Matthew J Barrett, Aaron E Bond, Diane S Huss, Jorge A Gonzalez Mejia, W Jeffrey Elias
OBJECTIVE: To examine nonmotor outcomes and correlates of quality of life (QoL) 3 and 12 months after unilateral focused ultrasound thalamotomy in tremor-dominant Parkinson disease (TDPD). METHODS: Twenty-seven patients with TDPD in a double-blind, sham-controlled, randomized clinical trial underwent comprehensive neuropsychological evaluations. These included assessment of mood, behavior, and QoL at baseline, 3 months, 3 months post crossover in the sham group, and 12 months after active treatment...
October 2, 2018: Neurology
https://www.readbyqxmd.com/read/30147869/objective-assessment-of-bradykinesia-in-parkinson-s-disease-using-evolutionary-algorithms-clinical-validation
#19
Chao Gao, Stephen Smith, Michael Lones, Stuart Jamieson, Jane Alty, Jeremy Cosgrove, Pingchen Zhang, Jin Liu, Yimeng Chen, Juanjuan Du, Shishuang Cui, Haiyan Zhou, Shengdi Chen
Background: There is an urgent need for developing objective, effective and convenient measurements to help clinicians accurately identify bradykinesia. The purpose of this study is to evaluate the accuracy of an objective approach assessing bradykinesia in finger tapping (FT) that uses evolutionary algorithms (EAs) and explore whether it can be used to identify early stage Parkinson's disease (PD). Methods: One hundred and seven PD, 41 essential tremor (ET) patients and 49 normal controls (NC) were recruited...
2018: Translational Neurodegeneration
https://www.readbyqxmd.com/read/30131429/local-field-potentials-of-subthalamic-nucleus-contain-electrophysiological-footprints-of-motor-subtypes-of-parkinson-s-disease
#20
MULTICENTER STUDY
Ilknur Telkes, Ashwin Viswanathan, Joohi Jimenez-Shahed, Aviva Abosch, Musa Ozturk, Akshay Gupte, Joseph Jankovic, Nuri F Ince
Although motor subtypes of Parkinson's disease (PD), such as tremor dominant (TD) and postural instability and gait difficulty (PIGD), have been defined based on symptoms since the mid-1990s, no underlying neural correlates of these clinical subtypes have yet been identified. Very limited data exist regarding the electrophysiological abnormalities within the subthalamic nucleus (STN) that likely accompany the symptom severity or the phenotype of PD. Here, we show that activity in subbands of local field potentials (LFPs) recorded with multiple microelectrodes from subterritories of STN provide distinguishing neurophysiological information about the motor subtypes of PD...
September 4, 2018: Proceedings of the National Academy of Sciences of the United States of America
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