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https://www.readbyqxmd.com/read/30337863/parkinson-s-disease-motor-subtypes-show-different-responses-to-long-term-subthalamic-nucleus-stimulation
#1
Cuiping Xu, Ping Zhuang, Mark Hallett, Yuqing Zhang, Jianyu Li, Yongjie Li
Background and purpose: Subthalamic nucleus deep brain stimulation (STN DBS) is well established for the treatment of advanced Parkinson's disease (PD), substantially improving motor symptoms, quality of life, and reducing the long-term need for dopaminergic medication. However, whether chronic STN DBS produces different effects on PD motor subtypes is unknown. This retrospective study aimed to evaluate the long-term effects of STN DBS on the PD motor subtypes. Methods: Eighty patients undergoing STN DBS were included...
2018: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/30321795/resting-state-network-connectivity-in-cognitively-unimpaired-drug-na%C3%A3-ve-patients-with-rigidity-dominant-parkinson-s-disease
#2
Yanbing Hou, Jing Yang, Chunyan Luo, Ruwei Ou, Yutong Zou, Wei Song, Qiyong Gong, Huifang Shang
BACKGROUND: Parkinson's disease (PD) could be classified into akinetic-rigidity (PDAR ), tremor-dominant (PDTD ) and mixed subtypes. PDAR patients are more prone to develop cognitive deficits. The default mode network (DMN), fronto-parietal network (FPN) and dorsal attention network (DAN) play important roles in cognitive processing. Our aim was to evaluate changes in connectivity patterns of the DMN, and its interrelation with the FPN and DAN in cognitively unimpaired drug-naïve PDAR patients...
October 3, 2018: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/30319535/beyond-dopamine-gaba-glutamate-and-the-axial-symptoms-of-parkinson-disease
#3
Ruth L O'Gorman Tuura, Christian R Baumann, Heide Baumann-Vogel
Introduction: The axial symptoms of Parkinson disease (PD) include difficulties with balance, posture, speech, swallowing, and locomotion with freezing of gait, as well as axial rigidity. These axial symptoms impact negatively on quality of life for many patients, yet remain poorly understood. Dopaminergic treatments typically have little effect on the axial symptoms of PD, suggesting that disruptions in other neurotransmitter systems beyond the dopamine system may underlie these symptoms. The purpose of the present study was to examine the relationship between the axial symptoms of PD and GABA and glutamate levels quantified with magnetic resonance spectroscopy...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/30297519/cognitive-decline-in-parkinson-s-disease-the-impact-of-the-motor-phenotype-on-cognition
#4
Jennifer Wojtala, Ines Ann Heber, Petra Neuser, Julia Heller, Elke Kalbe, Sarah P Rehberg, Alexander Storch, Katharina Linse, Christine Schneider, Susanne Gräber, Daniela Berg, Judith Dams, Monika Balzer-Geldsetzer, Rüdiger Hilker-Roggendorf, Carola Oberschmidt, Simon Baudrexel, Karsten Witt, Nele Schmidt, Günther Deuschl, Brit Mollenhauer, Claudia Trenkwalder, Inga Liepelt-Scarfone, Annika Spottke, Sandra Roeske, Ullrich Wüllner, Hans-Ulrich Wittchen, Oliver Riedel, Richard Dodel, Jörg B Schulz, Kathrin Reetz
OBJECTIVES: Parkinson's disease (PD) is the second most common neurodegenerative disorder and is further associated with progressive cognitive decline. In respect to motor phenotype, there is some evidence that akinetic-rigid PD is associated with a faster rate of cognitive decline in general and a greater risk of developing dementia.The objective of this study was to examine cognitive profiles among patients with PD by motor phenotypes and its relation to cognitive function. METHODS: Demographic, clinical and neuropsychological cross-sectional baseline data of the DEMPARK/LANDSCAPE study, a multicentre longitudinal cohort study of 538 patients with PD were analysed, stratified by motor phenotype and cognitive syndrome...
October 8, 2018: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/30288794/magnetic-resonance-guided-focused-ultrasound-thalamotomy-for-treatment-of-essential-tremor-a-2-year-outcome-study
#5
Ying Meng, Benjamin Solomon, Alexandre Boutet, Maheleth Llinas, Nadia Scantlebury, Yuexi Huang, Kullervo Hynynen, Clement Hamani, Alfonso Fasano, Andres M Lozano, Nir Lipsman, Michael L Schwartz
BACKGROUND: Magnetic resonance-guided focused ultrasound is an emerging, minimally invasive thermoablation technique for medically refractory essential tremor. Beyond the initial year, data regarding efficacy and potential predictors of efficacy are still preliminary. OBJECTIVES: The objective of this study was to assess the outcome at 2 years and the association between lesion volume and outcome 1 year after treatment. METHODS: We reviewed data from 37 patients who underwent unilateral magnetic resonance-guided focused ultrasound thalamotomy, with primary outcome being dominant tremor subscore of the Clinical Rating Scale for Tremor...
October 4, 2018: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/30244415/patterns-of-striatal-and-cerebellar-functional-connectivity-in-early-stage-drug-na%C3%A3-ve-patients-with-parkinson-s-disease-subtypes
#6
Yanbing Hou, Ruwei Ou, Jing Yang, Wei Song, Qiyong Gong, Huifang Shang
PURPOSE: Both the striatal-thalamo-cortical (STC) circuit and cerebello-thalamo-cortical (CTC) circuit play a critical role in Parkinson's disease (PD). METHODS: Resting-state functional MRI was used to assess functional connectivity (FC) focusing on the basal ganglia (BG) and cerebellum among early-stage drug-naïve PD patients with tremor-dominant (TD) PD patients with postural instability and gait dysfunction (PIGD) and healthy controls (HCs). RESULTS: Compared to HCs, both PD subgroups had higher FC between the cerebellum and paracentral lobule, sensorimotor areas; lower FC between the BG and superior frontal gyrus, and within the BG circuit; PD-TD patients showed higher FC between the BG and fusiform, paracentral lobule, cerebellum Lobule VI, and between the cerebellum and supplementary motor areas (SMA), insula; lower FC between the BG and rectus, sensorimotor areas, and within the cerebellum circuit; PD-PIGD patients showed higher FC between the cerebellum and middle frontal gyrus, precuneus; lower FC between the BG and cerebellum Crus II...
September 22, 2018: Neuroradiology
https://www.readbyqxmd.com/read/30227440/combined-unilateral-posteroventral-pallidotomy-and-ventral-intermediate-nucleus-thalamotomy-in-tremor-dominant-parkinson-apos-s-disease-versus-posteroventral-pallidotomy-alone-a-prospective-comparative-study
#7
Zeiad Y Fayed, Hesham Radwan, Mohamed Aziz, Mohamed Eid, Alia H Mansour, Mohamed Nosseir, Hisham Anwer, Tarek Elserry, Walid A Abdel Ghany
BACKGROUND: The optimum target in surgery for Parkinson's disease (PD) is still controversial, especially in patients with tremor-dominant PD. We aim to compare results in tremor-dominant patients undergoing pallidotomy vs. those undergoing simultaneous posteroventral pallidotomy (PVP) and ventral intermediate nucleus (VIM) thalamotomy. METHODS: Twenty-four patients with tremor-dominant PD were included in this study. Twelve patients received unilateral PVP contralateral to the most affected side...
2018: Stereotactic and Functional Neurosurgery
https://www.readbyqxmd.com/read/30186307/assessment-of-molecular-measures-in-non-fxtas-male-premutation-carriers
#8
Reem R Al Olaby, Hiu-Tung Tang, Blythe Durbin-Johnson, Andrea Schneider, David Hessl, Susan M Rivera, Flora Tassone
Approximately 30-40% of male and 8-16% of female carriers of the Fragile X premutation will develop a neurodegenerative movement disorder characterized by intentional tremor, gait ataxia, autonomic dysfunction, cognitive decline, and Parkinsonism during their lifetime. At the molecular level, premutation carriers have increased expression levels of the FMR1 and the antisense FMR1 ( ASFMR1) mRNAs. Both genes undergo alternative splicing giving rise to a number of different transcripts. Alteration in the alternative splicing process might be associated with FXTAS...
2018: Frontiers in Genetics
https://www.readbyqxmd.com/read/30160376/psychiatric-profile-of-motor-subtypes-of-de-novo-drug-na%C3%A3-ve-parkinson-s-disease-patients
#9
Francesca Assogna, Clelia Pellicano, Luca Cravello, Cinzia Savini, Mariangela Pierantozzi, Bruno Mercuri, Carlo Caltagirone, Francesco E Pontieri, Gianfranco Spalletta, Alessandro Stefani
BACKGROUND: Parkinson's disease (PD) is a heterogeneous neurodegenerative disorder. It is well established that different motor subtypes of PD evolve with different clinical courses and prognoses. The complete psychiatric profile underlying these different phenotypes since the very early stage of the disease is debated. AIMS OF THE STUDY: We aimed at investigating the psychiatric profile of the three motor subtypes of PD (akinetic-rigid, tremor-dominant, and mixed) in de novo drug-naïve patients with PD...
August 30, 2018: Brain and Behavior
https://www.readbyqxmd.com/read/30158164/mrigfus-in-tremor-dominant-pd-does-not-lead-to-substantial-cognitive-adverse-events
#10
EDITORIAL
Thomas M Zervos, Clement Hamani, Jason M Schwalb
No abstract text is available yet for this article.
October 2, 2018: Neurology
https://www.readbyqxmd.com/read/30158160/focused-ultrasound-thalamotomy-in-parkinson-disease-nonmotor-outcomes-and-quality-of-life
#11
Scott A Sperling, Binit B Shah, Matthew J Barrett, Aaron E Bond, Diane S Huss, Jorge A Gonzalez Mejia, W Jeffrey Elias
OBJECTIVE: To examine nonmotor outcomes and correlates of quality of life (QoL) 3 and 12 months after unilateral focused ultrasound thalamotomy in tremor-dominant Parkinson disease (TDPD). METHODS: Twenty-seven patients with TDPD in a double-blind, sham-controlled, randomized clinical trial underwent comprehensive neuropsychological evaluations. These included assessment of mood, behavior, and QoL at baseline, 3 months, 3 months post crossover in the sham group, and 12 months after active treatment...
October 2, 2018: Neurology
https://www.readbyqxmd.com/read/30147869/objective-assessment-of-bradykinesia-in-parkinson-s-disease-using-evolutionary-algorithms-clinical-validation
#12
Chao Gao, Stephen Smith, Michael Lones, Stuart Jamieson, Jane Alty, Jeremy Cosgrove, Pingchen Zhang, Jin Liu, Yimeng Chen, Juanjuan Du, Shishuang Cui, Haiyan Zhou, Shengdi Chen
Background: There is an urgent need for developing objective, effective and convenient measurements to help clinicians accurately identify bradykinesia. The purpose of this study is to evaluate the accuracy of an objective approach assessing bradykinesia in finger tapping (FT) that uses evolutionary algorithms (EAs) and explore whether it can be used to identify early stage Parkinson's disease (PD). Methods: One hundred and seven PD, 41 essential tremor (ET) patients and 49 normal controls (NC) were recruited...
2018: Translational Neurodegeneration
https://www.readbyqxmd.com/read/30131429/local-field-potentials-of-subthalamic-nucleus-contain-electrophysiological-footprints-of-motor-subtypes-of-parkinson-s-disease
#13
MULTICENTER STUDY
Ilknur Telkes, Ashwin Viswanathan, Joohi Jimenez-Shahed, Aviva Abosch, Musa Ozturk, Akshay Gupte, Joseph Jankovic, Nuri F Ince
Although motor subtypes of Parkinson's disease (PD), such as tremor dominant (TD) and postural instability and gait difficulty (PIGD), have been defined based on symptoms since the mid-1990s, no underlying neural correlates of these clinical subtypes have yet been identified. Very limited data exist regarding the electrophysiological abnormalities within the subthalamic nucleus (STN) that likely accompany the symptom severity or the phenotype of PD. Here, we show that activity in subbands of local field potentials (LFPs) recorded with multiple microelectrodes from subterritories of STN provide distinguishing neurophysiological information about the motor subtypes of PD...
September 4, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/30109466/disease-progression-in-parkinson-subtypes-the-ppmi-dataset
#14
Darko Aleksovski, Dragana Miljkovic, Daniele Bravi, Angelo Antonini
INTRODUCTION: Discrete patterns of progression have been suggested for patients with Parkinson disease and presenting tremor dominant (TD) or postural instability gait disorders (PIGD). However, longitudinal prospective assessments need to take into consideration the variability in clinical manifestations and the evidence that only 40% of initially classified PIGD remain in this subtype at subsequent visits. METHODS: We analyzed clinical progression of PIGD compared to TD using longitudinal clinical data from the PPMI...
August 14, 2018: Neurological Sciences
https://www.readbyqxmd.com/read/30108543/deep-brain-stimulation-in-moroccan-patients-with-parkinson-s-disease-the-experience-of-neurology-department-of-rabat
#15
Mounia Rahmani, Maria Benabdeljlil, Fouad Bellakhdar, Mustapha El Alaoui Faris, Mohamed Jiddane, Khalil El Bayad, Fatima Boutbib, Rachid Razine, Rachid Gana, Moulay R El Hassani, Nizar El Fatemi, Meryem Fikri, Siham Sanhaji, Hennou Tassine, Imane El Alaoui Balrhiti, Souad El Hadri, Najwa Ech-Cherif Kettani, Najia El Abbadi, Mourad Amor, Abdelmjid Moussaoui, Afifa Semlali, Saadia Aidi, El Hachmia Ait Benhaddou, Ali Benomar, Ahmed Bouhouche, Mohamed Yahyaoui, Abdeslam El Khamlichi, Abdessamad El Ouahabi, Rachid El Maaqili, Houyam Tibar, Yasser Arkha, Adyl Melhaoui, Abdelhamid Benazzouz, Wafa Regragui
Introduction: Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is known as a therapy of choice of advanced Parkinson's disease. The present study aimed to assess the beneficial and side effects of STN DBS in Moroccan Parkinsonian patients. Material and Methods: Thirty five patients underwent bilateral STN DBS from 2008 to 2016 in the Rabat University Hospital. Patients were assessed preoperatively and followed up for 6 to 12 months using the Unified Parkinson's Disease Rating Scale in four conditions (stimulation OFF and ON and medication OFF and ON), the levodopa-equivalent daily dose (LEDD), dyskinesia and fluctuation scores and PDQ39 scale for quality of life (QOL)...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/30095337/the-efficacy-and-limits-of-magnetic-resonance-guided-focused-ultrasound-pallidotomy-for-parkinson-s-disease-a-phase-i-clinical-trial
#16
Na Young Jung, Chang Kyu Park, Minsoo Kim, Phil Hyu Lee, Young Ho Sohn, Jin Woo Chang
OBJECTIVE Recently, MR-guided focused ultrasound (MRgFUS) has emerged as an innovative treatment for numerous neurological disorders, including essential tremor, Parkinson's disease (PD), and some psychiatric disorders. Thus, clinical applications with this modality have been tried using various targets. The purpose of this study was to determine the feasibility, initial effectiveness, and potential side effects of unilateral MRgFUS pallidotomy for the treatment of parkinsonian dyskinesia. METHODS A prospective, nonrandomized, single-arm clinical trial was conducted between December 2013 and May 2016 at a single tertiary medical center...
August 10, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/30062008/the-role-of-substantia-nigra-sonography-in-the-differentiation-of-parkinson-s-disease-and-multiple-system-atrophy
#17
Hai-Yan Zhou, Pei Huang, Qian Sun, Juan-Juan Du, Shi-Shuang Cui, Yun-Yun Hu, Wei-Wei Zhan, Ying Wang, Qin Xiao, Jun Liu, Yu-Yan Tan, Sheng-Di Chen
Background: The differential diagnosis of Parkinson's disease (PD) and multiple system atrophy (MSA) remains a challenge, especially in the early stage. Here, we assessed the value of transcranial sonography (TCS) to discriminate non-tremor dominant (non-TD) PD from MSA with predominant parkinsonism (MSA-P). Methods: Eighty-six MSA-P patients and 147 age and gender-matched non-TD PD patients who had appropriate temporal acoustic bone windows were included in this study...
2018: Translational Neurodegeneration
https://www.readbyqxmd.com/read/30054179/very-old-onset-parkinsonism-a-clinical-pathological-study
#18
Kurt A Jellinger
BACKGROUND: With increasing age of the world population, the number of parkinsonian patients with disease onset in very old age is expected to increase. Information about the clinical and morphological phenotype of very old age onset parkinsonism is poor, and only three autopsy-confirmed studies of parkinsonian patients of 80 years and older onset are available. METHODS: A retrospective autopsy study of 345 patients clinically diagnosed as Parkinson disease (PD) included 90 cases with disease onset ≥80 years)...
July 24, 2018: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/30053653/nationwide-survey-in-japan-endorsed-diagnostic-criteria-of-benign-adult-familial-myoclonus-epilepsy
#19
Katsuya Kobayashi, Takefumi Hitomi, Riki Matsumoto, Masako Watanabe, Ryosuke Takahashi, Akio Ikeda
PURPOSE: Benign adult familial myoclonus epilepsy (BAFME) is an autosomal dominant disease representing tremulous myoclonus or cortical tremor and infrequent generalized seizures. We aimed to delineate detailed epidemiological backgrounds in patients with Japanese BAFME and to establish diagnostic criteria based on clinical and electrophysiological findings. METHODS: After a previous survey on the current nationwide state of myoclonus epilepsy of adults in Japan, we conducted this survey to delineate the clinical characteristics of Japanese BAFME patients, using a questionnaire to obtain details for individual patients...
October 2018: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/30037690/neuromelanin-sensitive-mri-of-the-substantia-nigra-an-imaging-biomarker-to-differentiate-essential-tremor-from-tremor-dominant-parkinson-s-disease
#20
Jian Wang, Zhen Huang, Yuanfang Li, Fang Ye, Changpeng Wang, Yong Zhang, Xiaoqin Cheng, Guoqiang Fei, Kai Liu, Mengsu Zeng, Chunjiu Zhong, Lirong Jin
INTRODUCTION: We aimed to evaluate whether neuromelanin-sensitive MRI (NM-MRI) features in the substantia nigra pars compacta (SNc) were of diagnostic value to differentiate untreated essential tremor (ET) from de novo tremor-dominant Parkinson's disease (PDT ). METHODS: Eighteen untreated ET patients, 21 de novo PDT patients and 21 healthy control subjects were recruited. All the subjects underwent clinical examination, motor and cognitive evaluations, as well as NM-MRI...
July 17, 2018: Parkinsonism & related Disorders
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