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https://www.readbyqxmd.com/read/30109466/disease-progression-in-parkinson-subtypes-the-ppmi-dataset
#1
Darko Aleksovski, Dragana Miljkovic, Daniele Bravi, Angelo Antonini
INTRODUCTION: Discrete patterns of progression have been suggested for patients with Parkinson disease and presenting tremor dominant (TD) or postural instability gait disorders (PIGD). However, longitudinal prospective assessments need to take into consideration the variability in clinical manifestations and the evidence that only 40% of initially classified PIGD remain in this subtype at subsequent visits. METHODS: We analyzed clinical progression of PIGD compared to TD using longitudinal clinical data from the PPMI...
August 14, 2018: Neurological Sciences
https://www.readbyqxmd.com/read/30108543/deep-brain-stimulation-in-moroccan-patients-with-parkinson-s-disease-the-experience-of-neurology-department-of-rabat
#2
Mounia Rahmani, Maria Benabdeljlil, Fouad Bellakhdar, Mustapha El Alaoui Faris, Mohamed Jiddane, Khalil El Bayad, Fatima Boutbib, Rachid Razine, Rachid Gana, Moulay R El Hassani, Nizar El Fatemi, Meryem Fikri, Siham Sanhaji, Hennou Tassine, Imane El Alaoui Balrhiti, Souad El Hadri, Najwa Ech-Cherif Kettani, Najia El Abbadi, Mourad Amor, Abdelmjid Moussaoui, Afifa Semlali, Saadia Aidi, El Hachmia Ait Benhaddou, Ali Benomar, Ahmed Bouhouche, Mohamed Yahyaoui, Abdeslam El Khamlichi, Abdessamad El Ouahabi, Rachid El Maaqili, Houyam Tibar, Yasser Arkha, Adyl Melhaoui, Abdelhamid Benazzouz, Wafa Regragui
Introduction: Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is known as a therapy of choice of advanced Parkinson's disease. The present study aimed to assess the beneficial and side effects of STN DBS in Moroccan Parkinsonian patients. Material and Methods: Thirty five patients underwent bilateral STN DBS from 2008 to 2016 in the Rabat University Hospital. Patients were assessed preoperatively and followed up for 6 to 12 months using the Unified Parkinson's Disease Rating Scale in four conditions (stimulation OFF and ON and medication OFF and ON), the levodopa-equivalent daily dose (LEDD), dyskinesia and fluctuation scores and PDQ39 scale for quality of life (QOL)...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/30095337/the-efficacy-and-limits-of-magnetic-resonance-guided-focused-ultrasound-pallidotomy-for-parkinson-s-disease-a-phase-i-clinical-trial
#3
Na Young Jung, Chang Kyu Park, Minsoo Kim, Phil Hyu Lee, Young Ho Sohn, Jin Woo Chang
OBJECTIVE Recently, MR-guided focused ultrasound (MRgFUS) has emerged as an innovative treatment for numerous neurological disorders, including essential tremor, Parkinson's disease (PD), and some psychiatric disorders. Thus, clinical applications with this modality have been tried using various targets. The purpose of this study was to determine the feasibility, initial effectiveness, and potential side effects of unilateral MRgFUS pallidotomy for the treatment of parkinsonian dyskinesia. METHODS A prospective, nonrandomized, single-arm clinical trial was conducted between December 2013 and May 2016 at a single tertiary medical center...
August 10, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/30062008/the-role-of-substantia-nigra-sonography-in-the-differentiation-of-parkinson-s-disease-and-multiple-system-atrophy
#4
Hai-Yan Zhou, Pei Huang, Qian Sun, Juan-Juan Du, Shi-Shuang Cui, Yun-Yun Hu, Wei-Wei Zhan, Ying Wang, Qin Xiao, Jun Liu, Yu-Yan Tan, Sheng-Di Chen
Background: The differential diagnosis of Parkinson's disease (PD) and multiple system atrophy (MSA) remains a challenge, especially in the early stage. Here, we assessed the value of transcranial sonography (TCS) to discriminate non-tremor dominant (non-TD) PD from MSA with predominant parkinsonism (MSA-P). Methods: Eighty-six MSA-P patients and 147 age and gender-matched non-TD PD patients who had appropriate temporal acoustic bone windows were included in this study...
2018: Translational Neurodegeneration
https://www.readbyqxmd.com/read/30054179/very-old-onset-parkinsonism-a-clinical-pathological-study
#5
Kurt A Jellinger
BACKGROUND: With increasing age of the world population, the number of parkinsonian patients with disease onset in very old age is expected to increase. Information about the clinical and morphological phenotype of very old age onset parkinsonism is poor, and only three autopsy-confirmed studies of parkinsonian patients of 80 years and older onset are available. METHODS: A retrospective autopsy study of 345 patients clinically diagnosed as Parkinson disease (PD) included 90 cases with disease onset ≥80 years)...
July 24, 2018: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/30053653/nationwide-survey-in-japan-endorsed-diagnostic-criteria-of-benign-adult-familial-myoclonus-epilepsy
#6
Katsuya Kobayashi, Takefumi Hitomi, Riki Matsumoto, Masako Watanabe, Ryosuke Takahashi, Akio Ikeda
PURPOSE: Benign adult familial myoclonus epilepsy (BAFME) is an autosomal dominant disease representing tremulous myoclonus or cortical tremor and infrequent generalized seizures. We aimed to delineate detailed epidemiological backgrounds in patients with Japanese BAFME and to establish diagnostic criteria based on clinical and electrophysiological findings. METHODS: After a previous survey on the current nationwide state of myoclonus epilepsy of adults in Japan, we conducted this survey to delineate the clinical characteristics of Japanese BAFME patients, using a questionnaire to obtain details for individual patients...
July 19, 2018: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/30037690/neuromelanin-sensitive-mri-of-the-substantia-nigra-an-imaging-biomarker-to-differentiate-essential-tremor-from-tremor-dominant-parkinson-s-disease
#7
Jian Wang, Zhen Huang, Yuanfang Li, Fang Ye, Changpeng Wang, Yong Zhang, Xiaoqin Cheng, Guoqiang Fei, Kai Liu, Mengsu Zeng, Chunjiu Zhong, Lirong Jin
INTRODUCTION: We aimed to evaluate whether neuromelanin-sensitive MRI (NM-MRI) features in the substantia nigra pars compacta (SNc) were of diagnostic value to differentiate untreated essential tremor (ET) from de novo tremor-dominant Parkinson's disease (PDT ). METHODS: Eighteen untreated ET patients, 21 de novo PDT patients and 21 healthy control subjects were recruited. All the subjects underwent clinical examination, motor and cognitive evaluations, as well as NM-MRI...
July 17, 2018: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/30034772/quantitative-analysis-of-parkinsonian-tremor-in-a-clinical-setting-using-inertial-measurement-units
#8
Donatas Lukšys, Gintaras Jonaitis, Julius Griškevičius
Background: Parkinson's disease (PD) is a neurodegenerative disorder that affects human voluntary movements. Tremor is one of the most common symptoms of PD and is expressed as involuntary oscillation of the body. Tremors can be analysed in the frequency domain. Objective: The aim of the current study was to examine selected tremor parameters (frequency, root mean square, and approximated entropy) in order to quantify the characteristics of patients diagnosed with PD, compared to a healthy control group, and to compare the parameters by dividing the subjects according to UPDRS assessment...
2018: Parkinson's Disease
https://www.readbyqxmd.com/read/30019200/analysis-of-the-clinical-features-of-early-parkinson-s-disease-with-comparatively-integrated-intestinal-function
#9
Xiaoxue Guan, Yuchan Wang, Qun Li, Ming Wei, Lili Chen, Oumei Cheng
OBJECTIVE: Constipation is among the most frequently delineated nonmotor symptoms (NMS) with a high occurrence in Parkinson's disease (PD). The purpose of our study was to investigate whether PD with comparatively integrated intestinal function (without constipation) in the early stage had different clinical features compared to constipated PD. METHOD: We conducted a study of 105 consecutive de novo as well as early treated (treated for shorter than 3 months), aged 50 years or older outpatients...
July 17, 2018: Neurological Sciences
https://www.readbyqxmd.com/read/30017993/head-and-trunk-stability-during-gait-before-and-after-levodopa-intake-in-parkinson-s-disease-subtypes
#10
Paulo H S Pelicioni, Matthew A Brodie, Mark D Latt, Jasmine C Menant, Hylton B Menz, Victor S C Fung, Stephen R Lord
INTRODUCTION: People with Parkinson's disease (PD) can be classified into tremor dominant (TD) and postural instability and gait difficulty (PIGD) subtypes; the latter group having more impaired gait and increased fall risk. While there is some evidence that anti-parkinsonian medication, levodopa, might not improve balance and gait control or reduce fall risk in the PIGD subtype, it is unclear whether the levodopa dosage intake affects gait stability. To address these issues, this study used accelerometry to compare gait stability: (i) during before and after levodopa intake between non-PIGD and PIGD subtypes; (ii) between individuals who took less or >750 mg of levodopa/day...
July 3, 2018: Experimental Gerontology
https://www.readbyqxmd.com/read/30012679/case-of-fatal-familial-insomnia-caused-by-a-d178n-mutation-with-phenotypic-similarity-to-hashimoto-s-encephalopathy
#11
Jessica M Stevens, Matthew R Levine, Anne E Constantino, Gholam K Motamedi
Fatal familial insomnia (FFI) is a rare prion disease commonly inherited in an autosomal dominant pattern from a mutation in the PRioN Protein (PRNP) gene. Hashimoto's encephalopathy (HE) is characterised by encephalopathy associated with antithyroid peroxidase (TPO) or antithyroglobulin (Tg) antibodies. These two conditions characteristically have differing clinical presentations with dramatically different clinical course and outcomes. Here, we present a case of FFI mimicking HE. A woman in her 50s presented with worsening confusion, hallucinations, tremor and leg jerks...
July 15, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29988849/does-cataract-surgery-simulation-correlate-with-real-life-experience
#12
Ayşe Bozkurt Oflaz, Bengü Ekinci Köktekir, Süleyman Okudan
Objectives: To evaluate the correlation of cataract surgical simulator and real-life surgical experience and its contribution to surgical training. Materials and Methods: Sixteen doctors in our department were divided into three groups based on their surgical experience. After being familiarized with the device, the participants were evaluated while performing the navigation, forceps, bimanual practice, anti-tremor and capsulorhexis stages. The capsulorhexis stage was repeated five times...
June 2018: Turkish Journal of Ophthalmology
https://www.readbyqxmd.com/read/29984165/diffusion-mri-tractography-for-improved-transcranial-mri-guided-focused-ultrasound-thalamotomy-targeting-for-essential-tremor
#13
Qiyuan Tian, Max Wintermark, W Jeffrey Elias, Pejman Ghanouni, Casey H Halpern, Jaimie M Henderson, Diane S Huss, Maged Goubran, Christian Thaler, Raag Airan, Michael Zeineh, Kim Butts Pauly, Jennifer A McNab
Purpose: To evaluate the use of diffusion magnetic resonance imaging (MRI) tractography for neurosurgical guidance of transcranial MRI-guided focused ultrasound (tcMRgFUS) thalamotomy for essential tremor (ET). Materials and methods: Eight patients with medication-refractory ET were treated with tcMRgFUS targeting the ventral intermediate nucleus (Vim) of the thalamus contralateral to their dominant hand. Diffusion and structural MRI data and clinical evaluations were acquired pre-treatment and post-treatment...
2018: NeuroImage: Clinical
https://www.readbyqxmd.com/read/29981876/plasma-transferrin-level-correlates-with-the-tremor-dominant-phenotype-of-parkinson-s-disease
#14
Qian-Qian Si, Yong-Sheng Yuan, Yan Zhi, Qing Tong, Li Zhang, Kezhong Zhang
Accumulating evidence suggests that iron metabolism may be involved in the pathophysiology of Parkinson's disease (PD), and particularly in motor phenotype. This investigation aimed to examine plasma iron metabolism related indicators in patients with tremor-dominant phenotype of PD and determine less invasive, potential markers from plasma, which could partially reflect pathophysiological mechanisms of the brain. Seventy-six PD patients were recruited and thirty-three of them were classified into the tremor-dominant PD (TD-PD) group and forty-three into the non-tremor dominant PD (NT-PD) group, as determined by clinical characteristics...
July 5, 2018: Neuroscience Letters
https://www.readbyqxmd.com/read/29939203/intronic-pentanucleotide-tttca-repeat-insertion-in-the-samd12-gene-causes-familial-cortical-myoclonic-tremor-with-epilepsy-type-1
#15
Zhidong Cen, Zhengwen Jiang, You Chen, Xiaosheng Zheng, Fei Xie, Xiaodong Yang, Xingjiao Lu, Zhiyuan Ouyang, Hongwei Wu, Si Chen, Houmin Yin, Xia Qiu, Shuang Wang, Meiping Ding, Yelei Tang, Feng Yu, Caihua Li, Tao Wang, Hiroyuki Ishiura, Shoji Tsuji, Chuan Jiao, Chunyu Liu, Jianfeng Xiao, Wei Luo
Familial cortical myoclonic tremor with epilepsy is an autosomal dominant neurodegenerative disease, characterized by cortical tremor and epileptic seizures. Although four subtypes (types 1-4) mapped on different chromosomes (8q24, 2p11.1-q12.2, 5p15.31-p15.1 and 3q26.32-3q28) have been reported, the causative gene has not yet been identified. Here, we report the genetic study in a cohort of 20 Chinese pedigrees with familial cortical myoclonic tremor with epilepsy. Linkage and haplotype analysis in 11 pedigrees revealed maximum two-point logarithm of the odds (LOD) scores from 1...
June 23, 2018: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/29908405/objective-predictors-of-early-tolerance-to-ventral-intermediate-nucleus-of-thalamus-deep-brain-stimulation-in-essential-tremor-patients
#16
Shabbir Hussain Merchant, Sheng-Han Kuo, Yu Qiping, Linda Winfield, Guy McKhann, Sameer Sheth, Seth L Pullman, Blair Ford
OBJECTIVE: To identify pre-operative clinical and computerized spiral analysis characteristics that may help ascertain which patients with Essential Tremor (ET) will exhibit 'early tolerance' to ventral intermediate nucleus of thalamus (Vim) deep brain stimulation (DBS). METHODS: Identification of comparative characteristics of defined cases of 'early tolerance' versus patients with sustained satisfactory response treated with Vim DBS surgery for medically-refractory ET, based on retrospective chart review by a clinician blinded to the findings of computerized spiral analysis...
August 2018: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/29885986/clinical-electrophysiological-and-imaging-study-in-essential-tremor-parkinson-s-disease-syndrome
#17
Gennarina Arabia, Angela Lupo, Lucia Ilaria Manfredini, Basilio Vescio, Rita Nisticò, Gaetano Barbagallo, Maria Salsone, Maurizio Morelli, Fabiana Novellino, Giuseppe Nicoletti, Andrea Quattrone, Giuseppe Lucio Cascini, Elan D Louis, Aldo Quattrone
INTRODUCTION: Essential tremor-Parkinson's disease (ET-PD) syndrome is a clinical condition in which individuals with a long-lasting history of Essential tremor (ET) eventually develop Parkinson's disease (PD). The aim of the study was to investigate the accuracy performances of clinical, neurophysiological, and imaging biomarkers in differentiating patients affected by ET-PD syndrome from patients with ET or PD. METHODS: Nineteen patients affected by ET-PD syndrome, 48 ET patients, and 37 tremor-dominant PD (t-PD) patients were included...
June 5, 2018: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29878147/physiological-mechanisms-of-thalamic-ventral-intermediate-nucleus-stimulation-for-tremor-suppression
#18
Luka Milosevic, Suneil K Kalia, Mojgan Hodaie, Andres M Lozano, Milos R Popovic, William D Hutchison
Ventral intermediate thalamic deep brain stimulation is a standard therapy for the treatment of medically refractory essential tremor and tremor-dominant Parkinson's disease. Despite the therapeutic benefits, the mechanisms of action are varied and complex, and the pathophysiology and genesis of tremor remain unsubstantiated. This intraoperative study investigated the effects of high frequency microstimulation on both neuronal firing and tremor suppression simultaneously. In each of nine essential tremor and two Parkinson's disease patients who underwent stereotactic neurosurgery, two closely spaced (600 µm) microelectrodes were advanced into the ventral intermediate nucleus...
July 1, 2018: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/29867328/a-novel-posture-for-better-differentiation-between-parkinson-s-tremor-and-essential-tremor
#19
Bin Zhang, Feifei Huang, Jun Liu, Dingguo Zhang
Due to a lack of reliable non-invasive bio-markers, misdiagnosis between Parkinson's disease and essential tremor is common. Although some assistive engineering approaches have been proposed, little acceptance has been obtained for these methods lack well-studied mechanisms and involve operator-dependent procedures. Aiming at a better differentiation between the two tremor causes, we present a novel posture, termed arm-rested posture, to ameliorate the quality of recorded tremor sequences. To investigate its efficacy, the posture was compared with another common posture, called arm-stretching posture, in fundamental aspects of tremor intensity and dominant frequency...
2018: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/29843251/cognitive-impairment-and-mortality-in-a-population-based-parkinson-s-disease-cohort
#20
Adrienne M Keener, Kimberly C Paul, Aline Folle, Jeff M Bronstein, Beate Ritz
BACKGROUND: Parkinson's disease (PD) is a heterogeneous disorder with variability in phenotype and progression. OBJECTIVE: We describe characteristics of PD patients in the largest population-based cohort followed for progression to date, and evaluate clinical risk factors for cognitive impairment and mortality. METHODS: We collected longitudinal data using the Unified Parkinson's Disease Rating Scale (UPDRS), Mini-Mental State Exam (MMSE), and Geriatric Depression Scale (GDS) in 242 new-onset PD patients followed for progression...
2018: Journal of Parkinson's Disease
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