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Xiang-dong Fu

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https://www.readbyqxmd.com/read/30119262/assessment-of-dose-response-relationship-of-5-fluorouracil-to-murine-intestinal-injury
#1
Si Zhang, Yanan Liu, Daochun Xiang, Jinyu Yang, Dong Liu, Xiuhua Ren, Chengliang Zhang
5-Fluorouracil (5-FU) is the most frequently prescribed anti-tumor drug, but has been reported to result in intestinal injury. Although some progress has been made in understanding the intestinal toxicity of 5-FU, confusion remains about animal models of 5-FU-induced intestinal injury, especially the dosage of 5-FU. This study aims to assess the dose-response relationship between the severity of intestinal injury and different doses of 5-FU, and to determine a proper dosing for the murine model. We found that mice in the 5-FU groups gradually lost body weight over time...
July 12, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/30092463/biomechanical-fixation-properties-of-the-cortical-bone-trajectory-in-the-osteoporotic-lumbar-spine
#2
Hui-Min Li, Ren-Jie Zhang, Hai Gao, Chong-Yu Jia, Tao Xing, Jian-Xiang Zhang, Fu-Long Dong, Cai-Liang Shen
OBJECTIVE: Selecting optimal strategies for improving fixation in the osteoporotic lumbar spine remains an important issue in clinical research. Cortical bone trajectory (CBT) screws have been proven to enhance screw pullout strength. However, the biomechanical efficacy of these screws remains understudied. The aim of this study was to evaluate the biomechanical efficacy of CBT screws in the osteoporotic lumbar spine. METHODS: A total of 31 vertebrae from 14 cadaveric lumbar spines were obtained...
August 6, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/30074769/immuno-electrochemiluminescent-imaging-of-a-single-cell-based-on-functional-nanoprobes-of-heterogeneous-ru-bpy-3-2-sio-2-au-nanoparticles
#3
Jun-Tao Cao, Yu-Ling Wang, Jing-Jing Zhang, Yu-Xiang Dong, Fu-Rao Liu, Shu-Wei Ren, Yan-Ming Liu
It is valuable to develop a sensing platform for not only detecting a tumor marker in body fluids but also measuring its expression at single cells. In the present study, a simple closed bipolar electrodes-based electrochemiluminescence (BPEs-ECL) imaging strategy was developed for visual immunoassay of prostate specific antigen (PSA) at single cells using functional nanoprobes of heterogeneous Ru(bpy)3 2+ @SiO2 /Au nanoparticles. Multiple-assisted ECL signal amplification strategy was introduced into the detection system on the basis of the synergetic amplifying effect of the anodic and cathodic amplification...
August 17, 2018: Analytical Chemistry
https://www.readbyqxmd.com/read/30053258/the-rna-binding-protein-ews-is-broadly-involved-in-the-regulation-of-pri-mirna-processing-in-mammalian-cells
#4
Huiwu Ouyang, Kai Zhang, Kristi Fox-Walsh, Yang Yang, Chen Zhang, Jie Huang, Hairi Li, Yu Zhou, Xiang-Dong Fu
The Ewing Sarcoma protein (EWS) is a multifaceted RNA binding protein (RBP) with established roles in transcription, pre-mRNA processing and DNA damage response. By generating high quality EWS-RNA interactome, we uncovered its specific and prevalent interaction with a large subset of primary microRNAs (pri-miRNAs) in mammalian cells. Knockdown of EWS reduced, whereas overexpression enhanced, the expression of its target miRNAs. Biochemical analysis revealed that multiple elements in target pri-miRNAs, including the sequences flanking the stem-loop region, contributed to high affinity EWS binding and sequence swap experiments between target and non-target demonstrated that the flanking sequences provided the specificity for enhanced pri-miRNA processing by the Microprocessor Drosha/DGCR8...
December 1, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/29946642/-a-prospective-study-of-changes-in-oral-health-related-quality-of-life-during-all-on-four-immediate-restoration-for-edentulous-individuals
#5
Ting Tang, Lei Zhang, Yong-Fu Hou, Ying-Chun Jiang, Xiang-Dong Wang, Ning Chen
PURPOSE: This clinical study was to evaluate oral health-related quality of life (OHRQoL) changes in patients who underwent all-on-4 treatment in one or both jaws. METHODS: Eleven patients underwent placement of 4 to 6 dental implants on the basis of all-on-4 treatment concept in the maxilla, mandible or both jaws and immediate loading with acrylic interim prostheses. The prostheses were replaced after 3-6 months, and definitive prostheses with metal framework and reinforced resin facing were fixed after another 3 months or more...
February 2018: Shanghai Kou Qiang Yi Xue, Shanghai Journal of Stomatology
https://www.readbyqxmd.com/read/29942316/identification-of-dead-box-rna-helicase-ddx41-as-a-trafficking-protein-that-involves-in-multiple-innate-immune-signaling-pathways-in-a-zebrafish-model
#6
Jun-Xia Ma, Jiang-Yuan Li, Dong-Dong Fan, Wei Feng, Ai-Fu Lin, Li-Xin Xiang, Jian-Zhong Shao
DDX41 is an important sensor for host recognition of DNA viruses and initiation of nuclear factor-κB (NF-κB) and IFN signaling pathways in mammals. However, its occurrence and functions in other vertebrates remain poorly defined. Here, a DDX41 ortholog [ Danio rerio DDX41 ( Dr DDX41)] with various conserved structural features to its mammalian counterparts was identified from a zebrafish model. This Dr DDX41 was found to be a trafficking protein distributed in the nucleus of resting cells but transported into the cytoplasm under DNA stimulation...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29921316/induced-pluripotent-stem-cell-derived-mesenchymal-stem-cells-activate-quiescent-t-cells-and-elevate-regulatory-t-cell-response-via-nf-%C3%AE%C2%BAb-in-allergic-rhinitis-patients
#7
Xing-Liang Fan, Qing-Xiang Zeng, Xin Li, Cheng-Lin Li, Zhi-Bin Xu, Xue-Quan Deng, Jianbo Shi, Dong Chen, Song Guo Zheng, Qing-Ling Fu
BACKGROUND: It has been demonstrated previously that induced pluripotent stem cell (iPSC)-derived mesenchymal stem cells (MSCs) have immunosuppressive effects on activated T cells. However, the effects of iPSC-MSCs on quiescent T cells are still unknown. The aim of this study was to identify the immunomodulatory role of iPSC-MSCs on resting peripheral blood mononuclear cells (PBMCs) from allergic rhinitis (AR) patients. METHODS: PBMCs were cocultured with iPSC-MSCs without any stimulation, following which lymphocyte proliferation, activation of T cells, TH 1/TH 2 and regulatory T (Treg) cell differentiation, and Treg cell function were analyzed...
June 19, 2018: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29920068/thermoelectric-performance-of-sb-2-te-3-based-alloys-is-improved-by-introducing-pn-junctions
#8
Xiao-Yu Wang, Hui-Juan Wang, Bo Xiang, Liang-Wei Fu, Hao Zhu, Dong Chai, Bin Zhu, Yuan Yu, Na Gao, Zhong-Yue Huang, Fang-Qiu Zu
Interface engineering has been demonstrated to be an effective strategy for enhancing the thermoelectric (TE) performance of materials. However, a very typical interface in semiconductors, that is, the PN junction (PNJ), is scarcely adopted by the thermoelectrical community because of the coexistence of holes and electrons. Interestingly, our explorative results provide a definitively positive case that appropriate PNJs are able to enhance the TE performance of p-type Sb2 Te3 -based alloys. Specifically, owing to the formation of the charge-depletion layer and built-in electric field, the carrier concentration and transport can be optimized and thus the power factor is improved and the electronic thermal conductivity is decreased...
July 11, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29901061/towards-the-low-sensitive-and-high-energetic-co-crystal-explosive-cl-20-tnt-from-intermolecular-interactions-to-structures-and-properties
#9
Xiu-Qing Zhang, Jiao-Nan Yuan, Gurudeeban Selvaraj, Guang-Fu Ji, Xiang-Rong Chen, Dong-Qing Wei
Employing molecular dynamic (MD) simulations and solid-state density functional theory (DFT), we carried out thorough studies to understand the interaction-structure-property interrelationship of the co-crystal explosive 1 : 1 CL-20 : TNT. Our results revealed that the co-crystallization of CL-20 and TNT molecules enhances the intermolecular binding forces, where the main driving force for the formation of the co-crystal CL-20/TNT comes from HO and CO interactions, while OO contributes to the co-crystal stabilization...
June 27, 2018: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29878716/complications-and-prevention-strategies-of-oblique-lateral-interbody-fusion-technique
#10
Zhong-You Zeng, Zhao-Wan Xu, Deng-Wei He, Xing Zhao, Wei-Hu Ma, Wen-Fei Ni, Yong-Xing Song, Jian-Qiao Zhang, Wei Yu, Xiang-Qian Fang, Zhi-Jie Zhou, Nan-Jian Xu, Wen-Jian Huang, Zhi-Chao Hu, Ai-Lian Wu, Jian-Fei Ji, Jian-Fu Han, Shun-Wu Fan, Feng-Dong Zhao, Hui Jin, Fei Pei, Shi-Yang Fan, De-Xiu Sui
OBJECTIVE: To analyze the early complications and causes of oblique lateral interbody fusion, and put forward preventive measures. METHODS: There were 235 patients (79 males and 156 females) analyzed in our study from October 2014 to May 2017. The average age was 61.9 ± 0.21 years (from 32 to 83 years). Ninety-one cases were treated with oblique lateral interbody fusion (OLIF) alone (OLIF alone group) and 144 with OLIF combined with posterior pedicle screw fixation through the intermuscular space approach (OLIF combined group)...
May 2018: Orthopaedic Surgery
https://www.readbyqxmd.com/read/29851301/the-developmental-dynamics-of-the-populus-stem-transcriptome
#11
Qing Chao, Zhi-Fang Gao, Dong Zhang, Biligen-Gaowa Zhao, Feng-Qin Dong, Chun-Xiang Fu, Li-Jun Liu, Bai-Chen Wang
The Populus shoot undergoes primary growth (longitudinal growth) followed by secondary growth (radial growth), which produces biomass that is an important source of energy worldwide. We adopted joint PacBio Iso-Seq and RNA-seq analysis to identify differentially expressed transcripts along a developmental gradient from the shoot apex to the fifth internode of Populus Nanlin895. We obtained 87 150 full-length transcripts, including 2081 new isoforms and 62 058 new alternatively spliced isoforms, most of which were produced by intron retention, that were used to update the Populus annotation...
May 31, 2018: Plant Biotechnology Journal
https://www.readbyqxmd.com/read/29793557/human-ipsc-mscs-prevent-steroid-resistant-neutrophilic-airway-inflammation-via-modulating-th17-phenotypes
#12
Shu-Bin Fang, Hong-Yu Zhang, Ai-Yun Jiang, Xing-Liang Fan, Yong-Dong Lin, Cheng-Lin Li, Cong Wang, Xiang-Ci Meng, Qing-Ling Fu
BACKGROUND: Human induced pluripotent stem cells-derived mesenchymal stem cells (iPSC-MSCs) have been shown to be effective in Type 2 helper T cells (Th2)-dominant eosinophilic allergic airway inflammation. However, the role of iPSC-MSCs in Type 17 helper T cells (Th17)-dominant neutrophilic airway inflammation remains poorly studied. Therefore, this study was to explore the effects of iPSC-MSCs on an experimental mouse model of steroid-resistant neutrophilic airway inflammation and further determine the underlying mechanisms...
May 24, 2018: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29775926/chlorophyll-a-%C3%AF-uorescence-and-transcriptome-reveal-the-toxicological-effects-of-bisphenol-a-on-an-invasive-cyanobacterium-cylindrospermopsis-raciborskii
#13
Rong Xiang, Junqiong Shi, Hongbo Zhang, Congcong Dong, Li Liu, JunKe Fu, Xinyu He, Yanjun Yan, Zhongxing Wu
Bisphenol A has attracted worldwide attention due to its harmful effects on humans, animals and plants. In this study, the toxicological effects of BPA on Cylindrospermopsis raciborskii were assessed based on chlorophyll a fluorescence and transcriptome analyses. The results showed that the growth of C. raciborskii was significantly inhibited when BPA exceeded 0.1 mg L-1 . A marked rise of phase J was observed at a concentration greater than 0.1 mg L-1 , while a K phase appeared at 20 mg L-1 . The chlorophyll a fluorescence parameters of RC/CS0 , F0 , φP0 , φE0 , and ψ0 , underwent a significant decline under all treatments of BPA, whereas a significant increase in both VJ and M0 occurred under all concentrations of BPA...
July 2018: Aquatic Toxicology
https://www.readbyqxmd.com/read/29767260/rnai%C3%A2-mediated-downregulation-of-asparaginase%C3%A2-like-protein-1-inhibits-growth-and-promotes-apoptosis-of-human-cervical-cancer-line-siha
#14
Xiao-Feng Lv, Han-Qing Hong, Ling Liu, Shi-Hong Cui, Chen-Chen Ren, Hong-Yu Li, Xiao-An Zhang, Lin-Dong Zhang, Tian-Xiang Wei, Jin-Jin Liu, Wen-Ying Xing, Han Fu, Shu-Jun Yan
Asparaginase like 1 (ASRGL1) protein belongs to the N‑terminal nucleophile group, cleaving the isoaspartyl‑dipeptides and L‑asparagine by adding water. It tends to be overexpressed in cancerous tumors including ovarian cancer and breast tumors. The present study assessed the potential ability of ASRGL1 as a molecular target in gene‑based cervical cancer treatment. The protein expression level of ASRGL1 was determined in paraffin‑embedded tumor specimen by immunohistochemistry. Additionally, in order to assess the activity of ASRGL1 during the process of cervical cancer cell multiplication, ASRGL1‑short hairpin (sh) RNA‑expressing lentivirus was established, which was used to infect SiHa cells...
July 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29749964/peculiar-phase-diagram-with-isolated-superconducting-regions-in-thfeasn-1-x-o-x
#15
Bai-Zhuo Li, Zhi-Cheng Wang, Jia-Lu Wang, Fu-Xiang Zhang, Dong-Ze Wang, Feng-Yuan Zhang, Yu-Ping Sun, Qiang Jing, Hua-Fu Zhang, Shu-Gang Tan, Yu-Ke Li, Chun-Mu Feng, Yu-Xue Mei, Cao Wang, Guang-Han Cao
ThFeAsN1-x O x ([Formula: see text]) system with heavy electron doping has been studied by the measurements of x-ray diffraction, electrical resistivity, magnetic susceptibility and specific heat. The non-doped compound exhibits superconductivity at [Formula: see text] K, which is possibly due to an internal uniaxial chemical pressure that is manifested by the extremely small value of As height with respect to the Fe plane. With the oxygen substitution, the T c value decreases rapidly to below 2 K for [Formula: see text], and surprisingly, superconductivity re-appears in the range of [Formula: see text] with a maximum [Formula: see text] of 17...
June 27, 2018: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/29726233/-effects-of-irrigation-regimes-on-photosynthesis-water-use-efficiency-and-grain-yield-in-winter-wheat
#16
Fu Ju Ma, Cheng Yang, De Qi Zhang, Jun Qin Yue, Han Fang Wang, Yun Hui Shao, Bao Ting Fang, Xiang Dong Li
The effects of different irrigation regimes on photosynthesis, plant growth, water use efficiency (WUE), and grain yield in winter wheat were examined in a common garden with rainout shelter during 2013-2014 and 2014-2015 growing seasons. The experiment consisted of two irrigation timings, jointing stage (J) and anthesis (F), and three irrigation levels, 0, 37.5 and 75 mm, which generated nine irrigation combinations, i.e. J0 F0 , J0 F1 , J0 F2 , J1 F0 , J1 F1 , J1 F2 , J2 F0 , J2 F1 and J2 F2 . All plots received 75 mm irrigation at grain filling stage...
April 2018: Ying Yong Sheng Tai Xue Bao, the Journal of Applied Ecology
https://www.readbyqxmd.com/read/29723562/nematicidal-amide-alkaloids-from-the-seeds-of-clausena-lansium
#17
Yu-Jiao Fan, Hui-Qin Chen, Wen-Li Mei, Fan-Dong Kong, Fei-Xiang Li, Peng-Wei Chen, Cai-Hong Cai, Mian-Jia Huang, Hao-Fu Dai
Five new amide alkaloids (1-3, 5-6) were isolated from the seeds of Clausena lansium together with one new natural product (4) and four known analogues (7-10). The structures of the new amide alkaloids were elucidated based on a comprehensive spectroscopic data analysis including 1D and 2D NMR as well as HRESIMS, and by comparison with the literature. The bioactivity results showed that compound 8 expressed potent nematicidal activity against Panagrellus redivevus, with IC50 value of 0.12 mM, while compounds 3 and 5 presented moderate nematicidal activity with IC50 values of 2...
July 2018: Fitoterapia
https://www.readbyqxmd.com/read/29693734/metastable-mos2-crystal-structure-electronic-band-structure-synthetic-approach-and-intriguing-physical-properties
#18
Fu-Qiang Huang, Wei Zhao, Jie Pan, Yuqiang Fang, Xiangli Che, Dong Wang, Kejun Bu
The 2H molybdenum disulfide (MoS2), as a stable hexagonal phase, has been one of the most studied transition metal dichalcogenides over the past decades. In the last five years, the metastable phases of MoS2 (1T, 1T', 1T'', and 1T''') have been revival of interests. Different from the edge-sharing [MoS6] trigonal prisms in the 2H MoS2 phase, these metastable phases are composed of the edge-sharing [MoS6] octahedra, in which the neighboring Mo-Mo distances differ. Due to the various crystal structures and different electronic configurations of the building [MoS6] motifs, these metastable polytypes are endowed with intriguing physical properties and potential applications in diverse fields...
April 25, 2018: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29684478/vitamin-d-deficiency-promotes-prostatic-hyperplasia-in-middle-age-mice-through-exacerbating-local-inflammation
#19
Zhi-Hui Zhang, Biao Luo, Shen Xu, Lin Fu, Yuan-Hua Chen, Cheng Zhang, Hua Wang, Dong-Dong Xie, De-Xiang Xu
Vitamin D deficiency is especially prevalent in pregnant women and children. Our recent study demonstrated that vitamin D deficiency in early life disturbed testicular development. This study investigated the effects of vitamin D deficiency in early life on prostatic hyperplasia in middle-aged mice. In control group, dams and their male pups were fed with standard-chow diets. In VDD group, dams were fed with vitamin D deficient (VDD) diets throughout pregnancy and lactation. After weaning, male pups continued to be fed with VDD diets...
September 2018: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/29660467/investigation-of-constituents-from-cinnamomum-camphora-l-j-presl-and-evaluation-of-their-anti-inflammatory-properties-in-lipopolysaccharide-stimulated-raw-264-7-macrophages
#20
Yan-Ru Li, Chun-Sheng Fu, Wen-Jing Yang, Xiao-Ling Wang, Dan Feng, Xiao-Ning Wang, Dong-Mei Ren, Hong-Xiang Lou, Tao Shen
ETHNOPHARMACOLOGY RELEVANCE: Cinnamomum camphora (L.) J. Presl has been used for the traditional medicine as a therapeutic agent of inflammation-related diseases, including sprains, rheumatic arthritis, abdominal pain, cough and bronchitis, for a long history. The aim of the present study was to illustrate anti-inflammatory substances of C. camphora and their mechanism of action, and to establish the correlations between chemical constituents and traditional uses of this plant. MATERIALS AND METHODS: Chemical constituents were purified by chromatographic methods, and their structures were established based on spectroscopic analysis...
July 15, 2018: Journal of Ethnopharmacology
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