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Xiang-dong Fu

Ling-Xiang Yu, Bo-Lun Zhang, Yuan Yang, Meng-Chao Wang, Guang-Lin Lei, Yuan Gao, Hu Liu, Chao-Hui Xiao, Jia-Jia Xu, Hao Qin, Xiao-Ya Xu, Zi-Shuo Chen, Da-Dong Zhang, Fu-Gen Li, Shao-Geng Zhang, Rong Liu
Hepatocellular carcinoma (HCC) is one of the most common malignant tumors worldwide, and current treatments exhibit limited efficacy against advanced HCC. The majority of cancer-related deaths are caused by metastasis from the primary tumor, which indicates the importance of identifying clinical biomarkers for predicting metastasis and indicating prognosis. Patient-derived cells (PDCs) may be effective models for biomarker identification. In the present study, a wound healing assay was used to obtain 10 fast-migrated and 10 slow-migrated PDC cultures from 36 HCC samples...
October 29, 2018: Oncology Reports
Yansong Fu, Rui Yan, Dongli Liu, Shanwen Jiang, Lin Cui, Xiaowei Guo, Xiangjing Wang, Ji Zhang, Wensheng Xiang
A novel Gram-stain-negative, aerobic, rod-shaped plant growth promoting bacterium, NEAU-SY24T , was isolated from soil in Diaoshuihu, Heilongjiang, China. The isolate grew at temperatures 10-40 °C (optimum, 30 °C), pH 5-8 (optimum, pH 6) and in the presence of up to 1 % (w/v) NaCl, although NaCl was not required for growth. Phylogenetic analysis based on the 16S rRNA gene sequence indicated that strain NEAU-SY24T belonged to the genus Trinickia and was closely related to Trinickia dabaoshanensis NRRL B-59553T (99...
December 4, 2018: International Journal of Systematic and Evolutionary Microbiology
Xue-Wu Guo, Yu Zhang, Lu-Lu Li, Xiang-Yu Guan, Jian Guo, De-Guang Wu, Ye-Fu Chen, Dong-Guang Xiao
Background: The biological production of 2,3-butanediol from xylose-rich raw materials from Klebsiella pneumoniae is a low-cost process. RpoD , an encoding gene of the sigma factor, is the key element in global transcription machinery engineering and has been successfully used to improve the fermentation with Escherichia coli . However, whether it can regulate the tolerance in K. pneumoniae remains unclear. Results: In this study, the kpC mutant strain was constructed by altering the expression quantity and genotype of the rpoD gene, and this exhibited high xylose tolerance and 2,3-butanediol production...
2018: Biotechnology for Biofuels
Zhi Huang, Fu-Xiang Jiang, Jian Li, Dan Jiang, Ti-Gang Xiao, Ju-Hua Zeng
BACKGROUND: Anemia is one of the most common diseases of childhood and is a health problem globally, particularly in developing counties and in children less than 2 years of age. Anemia during childhood has short- and long-term effects on health. However, few studies have investigated the prevalence of anemia among children in Huaihua. Therefore, this study analyzed the prevalence and risk factors of anemia among children 6 to 23 months of age in Huaihua. METHODS: This cross-sectional study was conducted at a maternal and child health care hospital in Huaihua, from September to November 2017...
November 19, 2018: BMC Public Health
Hui Xia, Chun Liu, Cheng-Chung Li, Maobin Fu, Shingo Takahashi, Kang-Quan Hu, Koichi Aizawa, Suganuma Hiroyuki, Guojun Wu, Liping Zhao, Xiang-Dong Wang
Both incidence and death rate due to liver cancer have increased in the United States. Higher consumption of lycopene-rich tomato and tomato products is associated with a decreased risk of cancers. β-Carotene-15, 15'-oxygenase (BCO1), and β-carotene-9', 10'-oxygenase (BCO2) cleave lycopene to produce bioactive apo-lycopenoids. Although BCO1/BCO2 polymorphisms affect human and animal lycopene levels, whether dietary tomato consumption can inhibit high-fat diet (HFD)-promoted hepatocellular carcinoma (HCC) development and affect gut microbiota in the absence of BCO1/BCO2 is unclear...
November 16, 2018: Cancer Prevention Research
Chong-Jian Lu, Xiao-Ying Fan, Yue-Feng Guo, Zhen-Chao Cheng, Ji Dong, Jin-Zi Chen, Lian-Yan Li, Mei-Wen Wang, Ze-Kai Wu, Fei Wang, Xiang-Jun Tong, Ling-Fei Luo, Fu-Chou Tang, Zuo-Yan Zhu, Bo Zhang
Pancreatic endocrine islets are vital for glucose homeostasis. However, the islet developmental trajectory and its regulatory network are not well understood. To define the features of these specification and differentiation processes, we isolated individual islet cells from TgBAC(neurod1:EGFP) transgenic zebrafish and analyzed islet developmental dynamics across four different embryonic stages using a single-cell RNA-seq strategy. We identified proliferative endocrine progenitors, which could be further categorized by different cell cycle phases with the G1/S sub-population displaying a distinct differentiation potential...
November 8, 2018: Journal of Molecular Cell Biology
Hong-Bin Fan, Li-Xia Chen, Xue-Bin Qu, Chuan-Lu Ren, Xiu-Xiang Wu, Fu-Xing Dong, Bao-Le Zhang, Dian-Shuai Gao, Rui-Qin Yao
A correction has been published and is appended to both the HTML and PDF versions of this paper. The error has not been fixed in the paper.
October 29, 2018: Scientific Reports
Qing Zhang, Dong-Ye Yi, Bing-Zhou Xue, Wan-Wan Wen, Yin-Ping Lu, Ahmed Abdelmaksou, Min-Xuan Sun, De-Tian Yuan, Hong-Yang Zhao, Nan-Xiang Xiong, Wei Xiang, Peng Fu
Human glioma-associated mesenchymal stem cells (gbMSCs) are the stromal cell components that contribute to the tumourigenesis of malignant gliomas. Recent studies have shown that gbMSCs consist of two distinct subpopulations (CD90+ and CD90- gbMSCs). However, the different roles in glioma progression have not been expounded. In this study, we found that the different roles of gbMSCs in glioma progression were associated with CD90 expression. CD90high gbMSCs significantly drove glioma progression mainly by increasing proliferation, migration and adhesion, where as CD90low gbMSCs contributed to glioma progression chiefly through the transition to pericytes and stimulation of vascular formation via vascular endothelial cells...
October 27, 2018: Cell Death & Disease
Zhong-Jun Wang, Fu-Jun Yue, Si-Liang Li, Xiao-Dong Li, Shi-Lu Wang, Cai Li, Fa-Xiang Tao
Nitrogenous species, particularly nitrate, are some of the most significant contaminants in freshwater rivers and lakes in China, posing a significant threat to human and ecosystem health. To identify the major nitrate sources and transformation processes in a subtropical karst lake (Hongfeng, HF) in Southwest China, two sampling campaigns involving three lake profiles were conducted during the impoundment period (April) and flood period (August). Hydro-chemistry parameters, concentration of nitrogenous species, and dual isotopes of nitrate were analyzed...
October 25, 2018: Environmental Science. Processes & Impacts
Rui Yan, Yansong Fu, Dongli Liu, Shanwen Jiang, Hanxun Ju, Xiaokui Guo, Xiaowei Guo, Xiangjing Wang, Ji Zhang, Wensheng Xiang
A novel Gram-stain-positive, strictly aerobic strain, NEAU-SA1T , which showed a rod-coccus growth life cycle, was isolated from forest soil from Zhangjiajie, Hunan Province, China. The isolate grew at 10-40 °C (optimum 28 °C), at pH 5.0-10.0 (optimum pH 7.0) and in the presence of up to 5 % (w/v) NaCl, although NaCl was not required for growth. Phylogenetic analysis based on 16S rRNA gene sequences indicated that strain NEAU-SA1T belonged to the genus Arthrobacter and was closely related to Arthrobacter cupressi DSM 24664T (98...
October 23, 2018: International Journal of Systematic and Evolutionary Microbiology
Jone López-Erauskin, Takahiro Tadokoro, Michael W Baughn, Brian Myers, Melissa McAlonis-Downes, Carlos Chillon-Marinas, Joshua N Asiaban, Jonathan Artates, Anh T Bui, Anne P Vetto, Sandra K Lee, Ai Vy Le, Ying Sun, Mélanie Jambeau, Jihane Boubaker, Deborah Swing, Jinsong Qiu, Geoffrey G Hicks, Zhengyu Ouyang, Xiang-Dong Fu, Lino Tessarollo, Shuo-Chien Ling, Philippe A Parone, Christopher E Shaw, Martin Marsala, Clotilde Lagier-Tourenne, Don W Cleveland, Sandrine Da Cruz
Through the generation of humanized FUS mice expressing full-length human FUS, we identify that when expressed at near endogenous murine FUS levels, both wild-type and ALS-causing and frontotemporal dementia (FTD)-causing mutations complement the essential function(s) of murine FUS. Replacement of murine FUS with mutant, but not wild-type, human FUS causes stress-mediated induction of chaperones, decreased expression of ion channels and transporters essential for synaptic function, and reduced synaptic activity without loss of nuclear FUS or its cytoplasmic aggregation...
November 21, 2018: Neuron
Jing Hu, Hao Qian, Yuanchao Xue, Xiang-Dong Fu
PTB was initially discovered as a polypyrimidine tract-binding protein (hence the name), which corresponds to a specific RNA-binding protein associated with heterogeneous ribonucleoprotein particle (hnRNP I). The PTB family consists of three members in mammalian genomes, with PTBP1 (PTB) expressed in most cell types, PTBP2 (also known as nPTB or brPTB) exclusively found in the nervous system, and PTBP3 (also known as ROD1) predominately detected in immune cells. During neural development, PTB is down-regulated, which induces nPTB, and the expression of both PTB and nPTB becomes diminished when neurons mature...
2018: Biophysics Reports
Kai Zhang, Xiaorong Zhang, Zhiqiang Cai, Jie Zhou, Ran Cao, Ya Zhao, Zonggui Chen, Dehe Wang, Wen Ruan, Qian Zhao, Guangqiao Liu, Yuanchao Xue, Yan Qin, Bing Zhou, Ligang Wu, Timothy Nilsen, Yu Zhou, Xiang-Dong Fu
MicroRNAs (miRNAs) are well known to target 3' untranslated regions (3' UTRs) in mRNAs, thereby silencing gene expression at the post-transcriptional level. Multiple reports have also indicated the ability of miRNAs to target protein-coding sequences (CDS); however, miRNAs have been generally believed to function through similar mechanisms regardless of the locations of their sites of action. Here, we report a class of miRNA-recognition elements (MREs) that function exclusively in CDS regions. Through functional and mechanistic characterization of these 'unusual' MREs, we demonstrate that CDS-targeted miRNAs require extensive base-pairing at the 3' side rather than the 5' seed; cause gene silencing in an Argonaute-dependent but GW182-independent manner; and repress translation by inducing transient ribosome stalling instead of mRNA destabilization...
November 2018: Nature Structural & Molecular Biology
Hui-Min Li, Ren-Jie Zhang, Hai Gao, Chong-Yu Jia, Jian-Xiang Zhang, Fu-Long Dong, Cai-Liang Shen
BACKGROUND: Because of aging of population, osteoporotic vertebral compression fracture (OVCF) appears an increasing incidence rate. Conservative therapy (CT) and balloon kyphoplasty (BKP) have been used to treat OVCFs. However, an increase in new vertebral compression fractures at nontreated levels following BKP is of concern. It is still not clear whether new fractures were a result of BKP and the purpose of this meta-analysis was to evaluate the new fractures risk after BKP compared with CT...
October 2018: Medicine (Baltimore)
Jia-Xiang Wu, Lei Tong, Li Hu, Chun-Mei Xia, Min Li, Qing-Hui Chen, Fu-Xue Chen, Dong-Shu Du
The rostral ventrolateral medulla (RVLM) plays a key role in mediating the development of stress-induced hypertension (SIH) by excitation and/or inhibition of sympathetic preganglionic neurons. The voltage-gated sodium channel Nav1.6 has been found to contribute to neuronal hyperexcitability. To examine the expression of Nav1.6 in the RVLM during SIH, a rat model was established by administering electric foot-shocks and noises. We found that Nav1.6 protein expression in the RVLM of SIH rats was higher than that of control rats, peaking at the tenth day of stress...
October 4, 2018: Hypertension Research: Official Journal of the Japanese Society of Hypertension
Peng-Cheng Kang, Kai-Ming Leng, Yue-Ping Liu, Yang Liu, Yi Xu, Wei Qin, Jian-Jun Gao, Zhi-Dong Wang, Sheng Tai, Xiang-Yu Zhong, Yun-Fu Cui
BACKGROUND/AIMS: Cholangiocarcinoma (CCA) is one of the most common malignant tumors of the biliary tract originating from biliary epithelial cells. Although many therapeutic strategies have been developed to treat CCA, the survival rate for CCA patients is still quite low. Thus it is urgent to elucidate the pathogenesis of CCA and to explore novel therapeutic targets. miR-191 has been shown to be associated with many human solid cancers, but the function of miR-191 in CCA is still poorly understood...
2018: Cellular Physiology and Biochemistry
Xue-Lian Zhang, Han-Jing Fu, Guang-Ran Yang, Gang Wan, Dongmei Li, Liang-Xiang Zhu, Rong-Rong Xie, Yu-Jie Lv, Jian-Dong Zhang, Yu-Ling Li, Qin-Fang Dai, Yu Ji, Da-Yong Gao, Xue-Li Cui, De-Yuan Liu, Shen-Yuan Yuan, Ming-Xia Yuan
OBJECTIVE: We investigated the prognostic significance of metabolic risk scores and aspirin with respect to cerebrovascular events. METHODS: A total of 25 communities of diabetic patients were enrolled in Beijing Community Diabetes Study (BCDS) from 2008. 3413 patients with T2DM in BCDS have complete screening data, including blood glucose, blood pressure, lipid profiles and anti-platelet therapy, which were assigned metabolic score (MS) and add up to the total metabolic score (TMS)...
October 2018: Diabetes Research and Clinical Practice
Lin Zhou, Li-Chao Pan, Yong-Gen Zheng, Guo-Sheng Du, Xiao-Qian Fu, Zhi-Dong Zhu, Ji-Yong Song, Zhi-Jia Liu, Xiang-Zheng Su, Wen Chen, De-Hua Zheng, Long-Long Suo, Shao-Zhen Yang
Although liver transplantation (LT) lengthens the survival time of patients with hepatocellular carcinoma (HCC), LT patients exhibit a high recurrence rate; particularly those that had advanced HCC associated with the tumor biological characteristics and long-term application of immunosuppressants. A consensus on optimal prophylaxis and treatment for recurrent HCC following LT does not currently exist. The present study retrospectively analyzed data from 36 non-University of California at San Francisco criteria-eligible patients with advanced HCC who underwent LT, and then treated them with sirolimus (SRL)-based therapy with thymalfasin and huaier granules (SRL+, n=18), or with tacrolimus-based therapy (controls; n=18)...
October 2018: Oncology Letters
Xue-Lian Zhang, Ming-Xia Yuan, Gang Wan, Guang-Ran Yang, Dong-Mei Li, Han-Jing Fu, Liang-Xiang Zhu, Rong-Rong Xie, Jian-Dong Zhang, Yu-Jie Lv, Yu-Ling Li, Xue-Ping Du, Zi-Ming Wang, Xue-Li Cui, De-Yuan Liu, Ying Gao, Shu-Yan Cheng, Qian Wang, Yu Ji, Guang-Wei Li, Shen-Yuan Yuan
Objective: It is well known that diabetic kidney disease is a risk factor for cardiovascular diseases (CVD) in patients with type 2 diabetes mellitus (T2DM). In this study, the effects of urine albumin excretion rate (AER) and estimated glomerular filtration rate (eGFR) on CVD outcomes were analyzed in a population of T2DM. Methods: The study was carried out using recorded information of a cohort study. A total of 1,914 patients with T2DM with no prevalent CVD were enrolled in an 8 years prospective study and received multifactorial intervention...
2018: Therapeutics and Clinical Risk Management
Zhihong Zhou, Jinsong Qiu, Wen Liu, Yu Zhou, Ryan M Plocinik, Hairi Li, Qidong Hu, Gourisanker Ghosh, Joseph A Adams, Michael G Rosenfeld, Xiang-Dong Fu
No abstract text is available yet for this article.
September 6, 2018: Molecular Cell
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