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Xiang-dong Fu

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https://www.readbyqxmd.com/read/30310857/ptb-nptb-master-regulators-of-neuronal-fate-in-mammals
#1
Jing Hu, Hao Qian, Yuanchao Xue, Xiang-Dong Fu
PTB was initially discovered as a polypyrimidine tract-binding protein (hence the name), which corresponds to a specific RNA-binding protein associated with heterogeneous ribonucleoprotein particle (hnRNP I). The PTB family consists of three members in mammalian genomes, with PTBP1 (PTB) expressed in most cell types, PTBP2 (also known as nPTB or brPTB) exclusively found in the nervous system, and PTBP3 (also known as ROD1) predominately detected in immune cells. During neural development, PTB is down-regulated, which induces nPTB, and the expression of both PTB and nPTB becomes diminished when neurons mature...
2018: Biophysics Reports
https://www.readbyqxmd.com/read/30297778/a-novel-class-of-microrna-recognition-elements-that-function-only-within-open-reading-frames
#2
Kai Zhang, Xiaorong Zhang, Zhiqiang Cai, Jie Zhou, Ran Cao, Ya Zhao, Zonggui Chen, Dehe Wang, Wen Ruan, Qian Zhao, Guangqiao Liu, Yuanchao Xue, Yan Qin, Bing Zhou, Ligang Wu, Timothy Nilsen, Yu Zhou, Xiang-Dong Fu
MicroRNAs (miRNAs) are well known to target 3' untranslated regions (3' UTRs) in mRNAs, thereby silencing gene expression at the post-transcriptional level. Multiple reports have also indicated the ability of miRNAs to target protein-coding sequences (CDS); however, miRNAs have been generally believed to function through similar mechanisms regardless of the locations of their sites of action. Here, we report a class of miRNA-recognition elements (MREs) that function exclusively in CDS regions. Through functional and mechanistic characterization of these 'unusual' MREs, we demonstrate that CDS-targeted miRNAs require extensive base-pairing at the 3' side rather than the 5' seed; cause gene silencing in an Argonaute-dependent but GW182-independent manner; and repress translation by inducing transient ribosome stalling instead of mRNA destabilization...
October 8, 2018: Nature Structural & Molecular Biology
https://www.readbyqxmd.com/read/30290650/new-vertebral-fractures-after-osteoporotic-vertebral-compression-fracture-between-balloon-kyphoplasty-and-nonsurgical-treatment-prisma
#3
Hui-Min Li, Ren-Jie Zhang, Hai Gao, Chong-Yu Jia, Jian-Xiang Zhang, Fu-Long Dong, Cai-Liang Shen
BACKGROUND: Because of aging of population, osteoporotic vertebral compression fracture (OVCF) appears an increasing incidence rate. Conservative therapy (CT) and balloon kyphoplasty (BKP) have been used to treat OVCFs. However, an increase in new vertebral compression fractures at nontreated levels following BKP is of concern. It is still not clear whether new fractures were a result of BKP and the purpose of this meta-analysis was to evaluate the new fractures risk after BKP compared with CT...
October 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/30287879/upregulation-of-nav1-6-expression-in-the-rostral-ventrolateral-medulla-of-stress-induced-hypertensive-rats
#4
Jia-Xiang Wu, Lei Tong, Li Hu, Chun-Mei Xia, Min Li, Qing-Hui Chen, Fu-Xue Chen, Dong-Shu Du
The rostral ventrolateral medulla (RVLM) plays a key role in mediating the development of stress-induced hypertension (SIH) by excitation and/or inhibition of sympathetic preganglionic neurons. The voltage-gated sodium channel Nav1.6 has been found to contribute to neuronal hyperexcitability. To examine the expression of Nav1.6 in the RVLM during SIH, a rat model was established by administering electric foot-shocks and noises. We found that Nav1.6 protein expression in the RVLM of SIH rats was higher than that of control rats, peaking at the tenth day of stress...
October 4, 2018: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://www.readbyqxmd.com/read/30235453/mir-191-inhibition-induces-apoptosis-through-reactivating-secreted-frizzled-related-protein-1-in-cholangiocarcinoma
#5
Peng-Cheng Kang, Kai-Ming Leng, Yue-Ping Liu, Yang Liu, Yi Xu, Wei Qin, Jian-Jun Gao, Zhi-Dong Wang, Sheng Tai, Xiang-Yu Zhong, Yun-Fu Cui
BACKGROUND/AIMS: Cholangiocarcinoma (CCA) is one of the most common malignant tumors of the biliary tract originating from biliary epithelial cells. Although many therapeutic strategies have been developed to treat CCA, the survival rate for CCA patients is still quite low. Thus it is urgent to elucidate the pathogenesis of CCA and to explore novel therapeutic targets. miR-191 has been shown to be associated with many human solid cancers, but the function of miR-191 in CCA is still poorly understood...
2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/30218743/the-effects-of-cardiovascular-risk-factor-combined-anti-platelet-therapy-and-the-risk-of-cerebrovascular-events-in-patients-with-t2dm-in-an-urban-community-over-96-months-follow-up-the-beijing-communities-diabetes-study-19
#6
Xue-Lian Zhang, Han-Jing Fu, Guang-Ran Yang, Gang Wan, Dongmei Li, Liang-Xiang Zhu, Rong-Rong Xie, Yu-Jie Lv, Jian-Dong Zhang, Yu-Ling Li, Qin-Fang Dai, Yu Ji, Da-Yong Gao, Xue-Li Cui, De-Yuan Liu, Shen-Yuan Yuan, Ming-Xia Yuan
OBJECTIVE: We investigated the prognostic significance of metabolic risk scores and aspirin with respect to cerebrovascular events. METHODS: A total of 25 communities of diabetic patients were enrolled in Beijing Community Diabetes Study (BCDS) from 2008. 3413 patients with T2DM in BCDS have complete screening data, including blood glucose, blood pressure, lipid profiles and anti-platelet therapy, which were assigned metabolic score (MS) and add up to the total metabolic score (TMS)...
September 13, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/30214575/novel-strategy-of-sirolimus-plus-thymalfasin-and-huaier-granule-on-tumor-recurrence-of-hepatocellular-carcinoma-beyond-the-ucsf-criteria-following-liver-transplantation-a-single-center-experience
#7
Lin Zhou, Li-Chao Pan, Yong-Gen Zheng, Guo-Sheng Du, Xiao-Qian Fu, Zhi-Dong Zhu, Ji-Yong Song, Zhi-Jia Liu, Xiang-Zheng Su, Wen Chen, De-Hua Zheng, Long-Long Suo, Shao-Zhen Yang
Although liver transplantation (LT) lengthens the survival time of patients with hepatocellular carcinoma (HCC), LT patients exhibit a high recurrence rate; particularly those that had advanced HCC associated with the tumor biological characteristics and long-term application of immunosuppressants. A consensus on optimal prophylaxis and treatment for recurrent HCC following LT does not currently exist. The present study retrospectively analyzed data from 36 non-University of California at San Francisco criteria-eligible patients with advanced HCC who underwent LT, and then treated them with sirolimus (SRL)-based therapy with thymalfasin and huaier granules (SRL+, n=18), or with tacrolimus-based therapy (controls; n=18)...
October 2018: Oncology Letters
https://www.readbyqxmd.com/read/30214217/the-effects-of-aer-and-egfr-on-outcomes-of-cvd-in-patients-with-t2dm-in-an-urban-community-over-8-years-of-multifactorial-treatment-the-beijing-communities-diabetes-study-18
#8
Xue-Lian Zhang, Ming-Xia Yuan, Gang Wan, Guang-Ran Yang, Dong-Mei Li, Han-Jing Fu, Liang-Xiang Zhu, Rong-Rong Xie, Jian-Dong Zhang, Yu-Jie Lv, Yu-Ling Li, Xue-Ping Du, Zi-Ming Wang, Xue-Li Cui, De-Yuan Liu, Ying Gao, Shu-Yan Cheng, Qian Wang, Yu Ji, Guang-Wei Li, Shen-Yuan Yuan
Objective: It is well known that diabetic kidney disease is a risk factor for cardiovascular diseases (CVD) in patients with type 2 diabetes mellitus (T2DM). In this study, the effects of urine albumin excretion rate (AER) and estimated glomerular filtration rate (eGFR) on CVD outcomes were analyzed in a population of T2DM. Methods: The study was carried out using recorded information of a cohort study. A total of 1,914 patients with T2DM with no prevalent CVD were enrolled in an 8 years prospective study and received multifactorial intervention...
2018: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/30193100/the-akt-srpk-sr-axis-constitutes-a-major-pathway-in-transducing-egf-signaling-to-regulate-alternative-splicing-in-the-nucleus
#9
Zhihong Zhou, Jinsong Qiu, Wen Liu, Yu Zhou, Ryan M Plocinik, Hairi Li, Qidong Hu, Gourisanker Ghosh, Joseph A Adams, Michael G Rosenfeld, Xiang-Dong Fu
No abstract text is available yet for this article.
September 6, 2018: Molecular Cell
https://www.readbyqxmd.com/read/30175922/suicidality-and-clinical-correlates-in-chinese-men-who-have-sex-with-men-msm-with-hiv-infection
#10
Yuan-Yuan Wang, Min Dong, Qinge Zhang, Dan-Dan Xu, Jin Zhao, Chee H Ng, Gabor S Ungvari, Fu-Jun Jia, Yu-Tao Xiang
Little is known about suicidality in Chinese men who has sex with men (MSM) infected with human immunodeficiency virus (HIV). This study investigated suicidality and its clinical correlates in Chinese MSM with HIV infection. Suicidality, demographic and clinical characteristics were assessed in 410 MSM with HIV infection consecutively recruited from a public HIV clinic in China. The prevalence of suicidality was 10.7% in Chinese HIV-infected MSM. Compared with those without suicidality, MSM with suicidality were more likely to be younger, unmarried and unemployed, and have more frequent insomnia, lower CD4 lymphocyte counts, and higher GAD-7 and CSE-D total scores...
September 3, 2018: Psychology, Health & Medicine
https://www.readbyqxmd.com/read/30150286/characterization-of-an-nlrp1-inflammasome-from-zebrafish-reveals-a-unique-sequential-activation-mechanism-underlying-inflammatory-caspases-in-ancient-vertebrates
#11
Jiang-Yuan Li, Ke Gao, Tong Shao, Dong-Dong Fan, Chong-Bin Hu, Cen-Cen Sun, Wei-Ren Dong, Ai-Fu Lin, Li-Xin Xiang, Jian-Zhong Shao
NLRP1 inflammasome is one of the best-characterized inflammasomes in humans and other mammals. However, the existence of this inflammasome in nonmammalian species remains poorly understood. In this study, we report the molecular and functional identification of an NLRP1 homolog, Danio rerio NLRP1 ( Dr NLRP1) from a zebrafish ( D. rerio ) model. This Dr NLRP1 possesses similar structural architecture to mammalian NLRP1s. It can trigger the formation of a classical inflammasome for the activation of zebrafish inflammatory caspases ( D...
October 1, 2018: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/30145992/current-status-of-forest-medicine-research-in-china
#12
Qing Dong Huang, Qing Wu, Gen Xiang Mao, San Ying Wang, Bing Bing Jia, Guo Fu Wang
No abstract text is available yet for this article.
July 2018: Biomedical and Environmental Sciences: BES
https://www.readbyqxmd.com/read/30143053/current-status-and-potential-challenges-of-mesenchymal-stem-cell-based-therapy-for-malignant-gliomas
#13
REVIEW
Qing Zhang, Wei Xiang, Dong-Ye Yi, Bing-Zhou Xue, Wan-Wan Wen, Ahmed Abdelmaksoud, Nan-Xiang Xiong, Xiao-Bing Jiang, Hong-Yang Zhao, Peng Fu
Glioma, which accounts for more than 30% of primary central nervous system tumours, is characterised by symptoms such as headaches, epilepsy, and blurred vision. Glioblastoma multiforme is the most aggressive, malignant, and lethal brain tumour in adults. Even with progressive combination treatment with surgery, radiotherapy, and chemotherapy, the prognosis for glioma patients is still extremely poor. Compared with the poor outcome and slowly developing technologies for surgery and radiotherapy, the application of targeted chemotherapy with a new mechanism has become a research focus in this field...
August 24, 2018: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/30127978/decreased-crhbp-expression-is-predictive-of-poor-prognosis-in-patients-with-hepatocellular-carcinoma
#14
Hai-Bing Xia, Hui-Ju Wang, Luo-Qin Fu, Shi-Bing Wang, Li Li, Guo-Qing Ru, Xiang-Lei He, Xiang-Min Tong, Xiao-Zhou Mou, Dong-Sheng Huang
Corticotropin releasing hormone binding protein (CRHBP) mediates the reaction between corticotropin releasing hormone (CRH) and corticotropin releasing hormone receptors (CRHRs). It is expressed in a number of organs, and the expression of CRHBP is associated with tumorigenesis and cancer progression. The aim of the present study was to investigate CRHBP expression levels in hepatocellular carcinoma (HCC) and its association with patient clinicopathological characteristics as well as prognosis. The expression of CRHBP was examined by immunohistochemistry in 169 HCC tissues and 151 adjacent non-tumorous tissues...
September 2018: Oncology Letters
https://www.readbyqxmd.com/read/30127868/overexpression-of-tpx2-is-associated-with-progression-and-prognosis-of-prostate-cancer
#15
Jun Zou, Rui-Yan Huang, Fu-Neng Jiang, De-Xiong Chen, Cong Wang, Zhao-Dong Han, Yu-Xiang Liang, Wei-De Zhong
Targeting protein for Xenopus kinesin-like protein 2 (TPX2) activates Aurora kinase A during mitosis and targets its activity to the mitotic spindle, serving an important role in mitosis. It has been associated with different types of cancer and is considered to promote tumor growth. The aim of the present study was to explore the role of TPX2 in diagnosing prostate cancer (PCa). It was identified that TPX2 expression in PCa tissues was increased compared with benign prostate tissues. Microarray analysis demonstrated that TPX2 was positively associated with the Gleason score, tumor-node-metastasis (TNM) stage, clinicopathological stage, metastasis, overall survival and biochemical relapse-free survival...
September 2018: Oncology Letters
https://www.readbyqxmd.com/read/30127330/social-functions-of-relaxed-open-mouth-display-in-golden-snub-nosed-monkeys-rhinopithecus-roxellana
#16
You-Ji Zhang, Yi-Xin Chen, Hao-Chun Chen, Yuan Chen, Hui Yao, Wan-Ji Yang, Xiang-Dong Ruan, Zuo-Fu Xiang
Relaxed open-mouth display serves important social functions in relation to submission, reconciliation, affiliation and reassurance among non-human primate societies; however, quantitative evidence on this behavior remains insufficient among multi-level social groups. From July to November 2016, we examined four potential functions of the relaxed open-mouth display during pairwise, intra-unit social interactions among 18 free-ranging adult and sub-adult golden snub-nosed monkeys (Rhinopithecus roxellana) who belonged to three one-male, multi-female units (OMU) at Dalongtan, Shennongjia National Park, China...
August 13, 2018: Zoological Research
https://www.readbyqxmd.com/read/30125400/folic-acid-functionalized-zr-based-metal-organic-frameworks-as-drug-carriers-for-active-tumor-targeted
#17
Hong Dong, Gui-Xin Yang, Xin Zhang, Xiang-Bin Meng, Jing-Li Sheng, Xiao-Jun Sun, Yu-Jie Feng, Fengming Zhang
Nanoscale metal-organic frameworks (NMOFs) have been proved to be a class of promising drug carriers for their high porosity, crystalline nature with definite structure information and the potential of further functionality. However, MOF-based drug carriers with active tumor targeting function have not been extensive research until now. Here we show a strategy of constructing active tumor-targeted NMOFs drug carriers by anchoring functional folic acid (FA) molecules onto the metal clusters of NMOFs. Two Zr-based MOFs, MOF-808 and NH2-UiO-66, were chosen as model to cut down to nanoscale as drug carrier, then Zr6 cluster on the surface of the nano particle were further coordinated by the terminal carboxylate in FA molecule via the substitution to previous formate or terminal -OH ligands...
August 19, 2018: Chemistry: a European Journal
https://www.readbyqxmd.com/read/30119262/assessment-of-dose-response-relationship-of-5-fluorouracil-to-murine-intestinal-injury
#18
Si Zhang, Yanan Liu, Daochun Xiang, Jinyu Yang, Dong Liu, Xiuhua Ren, Chengliang Zhang
5-Fluorouracil (5-FU) is the most frequently prescribed anti-tumor drug, but has been reported to result in intestinal injury. Although some progress has been made in understanding the intestinal toxicity of 5-FU, confusion remains about animal models of 5-FU-induced intestinal injury, especially the dosage of 5-FU. This study aims to assess the dose-response relationship between the severity of intestinal injury and different doses of 5-FU, and to determine a proper dosing for the murine model. We found that mice in the 5-FU groups gradually lost body weight over time...
October 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/30092463/biomechanical-fixation-properties-of-the-cortical-bone-trajectory-in-the-osteoporotic-lumbar-spine
#19
Hui-Min Li, Ren-Jie Zhang, Hai Gao, Chong-Yu Jia, Tao Xing, Jian-Xiang Zhang, Fu-Long Dong, Cai-Liang Shen
OBJECTIVE: Selecting optimal strategies for improving fixation in osteoporotic lumbar spine is an important issue in clinical research. Cortical bone trajectory (CBT) screws have been proven to enhance screw pullout strength, but biomechanical efficacy of these screws remains understudied. The aim of this study was to evaluate biomechanical efficacy of CBT screws in osteoporotic lumbar spine. METHODS: Thirty-one vertebrae from 14 cadaveric lumbar spines were obtained...
August 6, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/30074769/immuno-electrochemiluminescent-imaging-of-a-single-cell-based-on-functional-nanoprobes-of-heterogeneous-ru-bpy-3-2-sio-2-au-nanoparticles
#20
Jun-Tao Cao, Yu-Ling Wang, Jing-Jing Zhang, Yu-Xiang Dong, Fu-Rao Liu, Shu-Wei Ren, Yan-Ming Liu
It is valuable to develop a sensing platform for not only detecting a tumor marker in body fluids but also measuring its expression at single cells. In the present study, a simple closed bipolar electrodes-based electrochemiluminescence (BPEs-ECL) imaging strategy was developed for visual immunoassay of prostate specific antigen (PSA) at single cells using functional nanoprobes of heterogeneous Ru(bpy)3 2+ @SiO2 /Au nanoparticles. Multiple-assisted ECL signal amplification strategy was introduced into the detection system on the basis of the synergetic amplifying effect of the anodic and cathodic amplification...
September 4, 2018: Analytical Chemistry
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