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Benign prostatic hypertrophy

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https://www.readbyqxmd.com/read/29674995/serum-steroid-ratio-profiles-in-prostate-cancer-a-new-diagnostic-tool-toward-a-personalized-medicine-approach
#1
Adriana Albini, Antonino Bruno, Barbara Bassani, Gioacchino D'Ambrosio, Giuseppe Pelosi, Paolo Consonni, Laura Castellani, Matteo Conti, Simone Cristoni, Douglas M Noonan
Background: Serum steroids are crucial molecules altered in prostate cancer (PCa). Mass spectrometry (MS) is currently the elected technology for the analysis of steroids in diverse biological samples. Steroids have complex biological pathways and stoichiometry and it is important to evaluate their quantitative ratio. MS applications to patient hormone profiling could lead to a diagnostic approach. Methods: Here, we employed the Surface Activated Chemical Ionization-Electrospray-NIST (SANIST) developed in our laboratories, to obtain quantitative serum steroid ratio relationship profiles with a machine learning Bayesian model to discriminate patients with PCa...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29672561/rich-table-but-short-life-diffuse-idiopathic-skeletal-hyperostosis-in-danish-astronomer-tycho-brahe-1546-1601-and-its-possible-consequences
#2
Sacha Kacki, Petr Velemínský, Niels Lynnerup, Sylva Kaupová, Alizé Lacoste Jeanson, Ctibor Povýšil, Martin Horák, Jan Kučera, Kaare Lund Rasmussen, Jaroslav Podliska, Zdeněk Dragoun, Jiří Smolík, Jens Vellev, Jaroslav Brůžek
The exhumation of Danish astronomer Tycho Brahe (1546-1601) was performed in 2010 to verify speculative views on the cause of his death. Previous analyses of skeletal and hair remains recovered from his grave refuted the presumption that he died from poisoning. These studies also outlined the possibility that he actually died from an acute illness, echoing the rather vague and inaccurate testimony of some historical records. We performed a detailed paleopathological analysis of Tycho Brahe's skeletal remains, along with a reconstruction of his diet based on carbon and nitrogen stable isotopes analysis and an estimate of his physical status (relative body fat) based on medullar and cortical dimensions of the femoral shaft...
2018: PloS One
https://www.readbyqxmd.com/read/29609886/risk-factors-for-reinsertion-of-urinary-catheter-after-early-removal-in-thoracic-surgical-patients
#3
John Young, Travis Geraci, Steven Milman, Andrew Maslow, Richard N Jones, Thomas Ng
OBJECTIVES: To reduce the incidence of urinary tract infection, Surgical Care Improvement Project 9 mandates the removal of urinary catheters within 48 hours postoperatively. In patients with thoracic epidural anesthesia, we sought to determine the rate of catheter reinsertion, the complications of reinsertion, and the factors associated with reinsertion. METHODS: We conducted a prospective observational study of consecutive patients undergoing major pulmonary or esophageal resection with thoracic epidural analgesia over a 2-year period...
March 8, 2018: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29603556/caffeic-acid-phenethyl-ester-guards-against-benign-prostate-hypertrophy-in-rats-role-of-igf-1r-protein-kinase-b-akt-%C3%AE-catenin-signaling
#4
Hany A Omar, Mai F Tolba
Benign prostate hypertrophy (BPH) is among the most common diseases with a huge impact on the quality of life of elderly men. There is a current need for the development of well-tolerated and effective preventive strategies to improve the clinical outcome. Caffeic acid phenethyl ester (CAPE) is an important active ingredient isolated from honey-bee propolis with potent anti-proliferative, anti-inflammatory and antioxidant effects. These properties promote CAPE as a promising candidate to be tested as an alternative therapy for BPH, which is still uninvestigated...
March 30, 2018: IUBMB Life
https://www.readbyqxmd.com/read/29572798/clinical-usefulness-of-the-histoculture-drug-response-assay-for-prostate-cancer-and-benign-prostate-hypertrophy-bph
#5
Robert M Hoffman
The histoculture drug response assay (HDRA) has been adapted to determine androgen sensitivity in Gelfoam histoculture of human benign prostatic tissue as well as prostate cancer. Gelfoam histoculture was used to measure androgen-independent and androgen-dependent growth of benign and malignant prostate tissue. The androgen-sensitivity index was significantly higher in 23 paired specimens of prostate cancer compared to benign prostate hypertrophy (BPH). Genistein decreased the androgen-sensitivity index of BPH and prostate cancer in Gelfoam® histoculture in a dose-dependent manner...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29528973/investigational-procedures-in-benign-prostatic-hypertrophy
#6
Joseph Acquaye, Michael S Borofsky
PURPOSE OF REVIEW: As benign prostatic hypertrophy (BPH) becomes a more common disease, there has been a dramatic rise in the number of investigational procedures being developed to manage it. We seek to present an overview of the most recently developed treatments and present clinical data related to application wherever available. RECENT FINDINGS: As a greater number of treatments become available for BPH, improved diagnostic testing could prove beneficial in helping guide patient selection...
May 2018: Current Opinion in Urology
https://www.readbyqxmd.com/read/29430891/flexible-robotics-in-pelvic-disease-what-pathologies-does-the-catheter-increase-applicability-of-embolic-therapy
#7
Maria A Rueda, Celia Riga, Mohamad S Hamady
Interventional Radiology procedures, equipment and techniques as well as image guidance have developed dramatically over the last few decades. The evidence for minimally invasive interventions in vascular and oncology fields is rapidly growing and several procedures are considered the first line management. However, radiation exposure, image guidance and innovative solutions to known anatomical challenges are still lagging behind. Robotic technology and its role in surgery have been developing at a steady speed...
February 8, 2018: Journal of Cardiovascular Surgery
https://www.readbyqxmd.com/read/29398458/the-potential-role-of-micrornas-as-biomarkers-in-benign-prostatic-hyperplasia-a-systematic-review-and-meta-analysis
#8
REVIEW
Francesco Greco, Antonino Inferrera, Roberto La Rocca, Michele Navarra, Marco Casciaro, Gaetano Grosso, Sebastiano Gangemi, Vincenzo Ficarra, Vincenzo Mirone
CONTEXT: Benign prostate hyperplasia (BPH) is one of the most common urologic diseases. However, the molecular and cellular mechanisms involving the stromal and epithelial components of the prostate that lead to BPH remain unclear. OBJECTIVE: To review and evaluate the evidence implicating microRNAs (miRNAs) in the pathogenesis of BPH. EVIDENCE ACQUISITION: A systematic search of the PubMed and Embase databases was performed using the terms "benign prostate hypertrophy and miRNA" or ("benign prostate hypertrophy and microRNAs" or "miRNA" or "miR") on July 31, 2017...
February 2, 2018: European Urology Focus
https://www.readbyqxmd.com/read/29373807/prostate-ultrasound-imaging-evaluation-of-a-two-step-scoring-system-in-the-diagnosis-of-prostate-cancer
#9
Yong Gao, Xin-Hong Liao, Yan Ma, Lu Lu, Li-Yan Wei, Xue Yan
RATIONALE AND OBJECTIVES: This study aims to investigate the feasibility and performance of a two-step scoring system of ultrasound imaging in the diagnosis of prostate cancer. MATERIAL AND METHODS: 75 patients with 888 consecutive histopathologically verified lesions were included in this study. Step 1, an initial 5-point scoring system was developed based on conventional transrectal ultrasound (TRUS). Step 2, a final scoring system was evaluated according to contrast-enhanced transrectal ultrasound (CE-TRUS)...
December 2017: Discovery Medicine
https://www.readbyqxmd.com/read/29372955/donegal-going-against-the-flow-national-differences-in-long-term-urinary-catheterisation-rates-in-men-65-years-with-benign-prostatic-hypertrophy
#10
R Stewart, S Maguire, K Hanley, P Armstrong
An analysis of Primary Care Reimbursement Service (PCRS, 2013) data demonstrated high rates of urinary catheter changes in Donegal compared to other regions of Ireland. There is a catheter change rate of 10.2% in Donegal men over 65 with medical cards (GMS) compared to rates of 2.7% and 0.17% in Waterford and South Dublin, respectively1. This 60-fold difference between an area with perceived good access to services (South Dublin) and Donegal an area that does not, prompted a survey of general practitioners in each of these areas to assess whether true male catheterisation rates were similarly disproportionate in Donegal...
September 18, 2017: Irish Medical Journal
https://www.readbyqxmd.com/read/29360485/development-of-a-clinically-relevant-men-s-health-phenotype-and-correlation-of-systemic-and-urologic-conditions
#11
Daniel A Shoskes, Sarah C Vij, Aaron Shoskes, Yaw Nyame, Tianming Gao
OBJECTIVE: To develop a clinically relevant men's health phenotype and investigate the correlation between severity of urologic symptoms and systemic health conditions METHODS: Retrospective chart review was performed for men seeking care for benign prostatic hypertrophy, erectile dysfunction or chronic prostatitis or chronic pelvic pain syndrome. Urologic symptoms were assessed with the International Prostate Symptom Score, Sexual Health Inventory for Men, and National Institute of Health Chronic Prostatitis Symptom Score...
April 2018: Urology
https://www.readbyqxmd.com/read/29318957/research-brief-self-reports-of-a-constellation-of-persistent-antiandrogenic-estrogenic-physical-and-psychological-effects-of-finasteride-usage-among-men
#12
Alicia A Walf, Shan Kaurejo, Cheryl A Frye
Our research objective is to understand more, through subjective, self-reports on discussion boards/forums, persons' experiences associated with the use of drugs that alter androgen metabolism, such as finasteride. Finasteride is an orally active, specific inhibitor of 5α-reductase, which is localized to many androgen-dependent tissues. Finasteride inhibits the conversion of testosterone (T) to dihydrotestosterone (DHT), and is commonly used to treat benign prostatic hypertrophy (BPH) and male pattern baldness (MPB), both disorders associated with elevated DHT levels and 5α-reductase activity in the prostate and hair follicles, respectively...
January 1, 2018: American Journal of Men's Health
https://www.readbyqxmd.com/read/29048765/ageratum-conyzoides-l-inhibits-5-alpha-reductase-gene-expression-in-human-prostate-cells-and-reduces-symptoms-of-benign-prostatic-hypertrophy-in-otherwise-healthy-men-in-a-double-blind-randomized-placebo-controlled-clinical-study
#13
Matthew Detering, Elizabeth Steels, Sundar Rao Koyyalamudi, Elena Allifranchini, Elena Bocchietto, Luis Vitetta
A double-blind, randomized, placebo-controlled clinical trial assessed the efficacy and safety of Ageratum conyzoides in treating benign prostatic hypertrophy (BPH). In this study, 109 men with medically diagnosed BPH, aged 41-76 years, were administered the investigational product, A. conyzoides extract at a dose of 250 mg/d or placebo, q.d. for 12 weeks. The primary outcome measures were the International Prostate Symptom Score (IPSS), daily urinary frequency and safety evaluations. The secondary outcome measures were testosterone, dihydrotestosterone, oestradiol, sex hormone binding globulin (SHBG), Dehydroepiandrosterone sulfate (DHEA-S) and cortisol levels, and prostate specific antigen (PSA), lipids, blood glucose, the Aging Male's Symptom (AMS) Score and sexual function assessed by Derogatis Interview for Sexual Functioning-Self Report (DISF-SR)...
November 2017: BioFactors
https://www.readbyqxmd.com/read/28894411/bilateral-hydroureteronephrosis-with-a-hypertrophied-trabeculated-urinary-bladder
#14
Showkathali Iqbal, Iqbal Raiz, Iqbal Faiz
Bilateral hydroureteronephrosis involves the dilatation of the renal pelvis, calyces and ureter; it develops secondary to urinary tract obstruction and leads to a build-up of back pressure in the urinary tract, and it may lead to impairment of renal function and ultimately culminate in renal failure. Although clinically silent in most cases, it can be diagnosed as an incidental finding during evaluation of an unrelated cause. In a minority of patients, it presents with signs and symptoms. Renal calculus is the most common cause, but there are multiple non-calculus aetiologies, and they depend on age and sex...
March 2017: Malaysian Journal of Medical Sciences: MJMS
https://www.readbyqxmd.com/read/28856711/rationale-and-design-of-the-canari-study-a-case-control-study-investigating-the-association-between-prostate-cancer-and-5-alpha-reductase-inhibitors-for-symptomatic-benign-prostate-hypertrophy-by-linking-sniiram-and-pathology-laboratories-in-a-specific-region
#15
Lucie-Marie Scailteux, Frédéric Balusson, Sébastien Vincendeau, Nathalie Rioux-Leclercq, Emmanuel Nowak
Benign prostate hypertrophy (BPH) could be associated with low urinary symptoms requiring medical treatment: 5-alpha-reductase inhibitors (5-ARI) or ɑ-blockers. Two clinical trials investigating 5-ARI use in prostate cancer (PCa) primary prevention highlighted a potential safety signal with an increased risk of high-grade PCa. Later observational studies failed to show similar results but have some limits. This paper focuses on describing the protocol of the CANARI study and its feasibility, as regards the matching process of two pseudo-anonymous databases...
February 2018: Fundamental & Clinical Pharmacology
https://www.readbyqxmd.com/read/28853814/magnetic-resonance-imaging-and-clinical-findings-in-seminal-vesicle-pathologies
#16
Zafer Ozmen, Fatma Aktas, Nihat Uluocak, Eda Albayrak, Ayşegül Altunkaş, Fatih Çelikyay
PURPOSE: Congenital and acquired pathologies of the seminal vesicles (SV) are rare diseases. The diagnosis of SV anomalies is frequently delayed or wrong due to the rarity of these diseases and the lack of adequate evaluation of SV pathology. For this reason, we aimed to comprehensively evaluate SV pathologies and accompanying genitourinary system abnormalities. MATERIALS AND METHODS: Between March 2012 and December 2015, 1455 male patients with different provisional diagnosis underwent MRI...
August 30, 2017: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/28845321/evaluation-of-anterior-segment-changes-of-patients-taking-alpha1-blockers-by-ultrasound-biomicroscopy-in-the-drug-free-period
#17
Yeliz Acar, Kadir Eltutar, Sibel Zırtıloğlu
OBJECTIVES: To evaluate and compare anterior segment changes in patients taking alpha-1 (α1) blockers (tamsulosin, terazosin, doxazosin, alfuzosin) for benign prostatic hypertrophy, during drug intake and drug-free period, using ultrasound biomicroscopy (UBM). MATERIALS AND METHODS: In this prospective study, UBM was done before and after pupil dilatation in 31 phakic eyes of 19 male patients taking α1-blockers. Undilated and dilated UBM was repeated before cataract extraction, after stopping the drug for 10 days...
August 2017: Turkish Journal of Ophthalmology
https://www.readbyqxmd.com/read/28793363/falls-a-fear-of-falling-and-related-factors-in-older-adults-with-complex-chronic-disease
#18
JuHee Lee, MoonKi Choi, Chang Oh Kim
AIMS AND OBJECTIVES: To identify factors influencing falls and the fear of falling among older adults with chronic diseases in Korea. BACKGROUND: The fear of falling and falls in older adults are significant health problems towards which healthcare providers should direct their attention. Further investigation is needed to improve nursing practice specifically decreasing risk of falls and the fear of falling in Korea. DESIGN: Descriptive, cross-sectional survey...
December 2017: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/28761594/case-series-bladder-clot-evacuation-using-a-prostate-morcellation-device
#19
Karen M Doersch, Andrew F Navetta, Erin T Bird, Marawan M El Tayeb
INTRODUCTION: We sought to provide a technical update on the use of a prostate morcellator device (PMD) to manage organized blood clots of the bladder following laser prostatectomy. METHODS: Herein, we describe our experience in using the Wolf Piranha morcellator in managing organized bladder blood clots supplemented with a retrospective chart review of the patients in whom this procedure was performed. RESULTS: Six patients, all male with a mean age of 75 ± 8...
July 2017: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
https://www.readbyqxmd.com/read/28721283/stereological-comparison-of-intraprostatic-injection-of-alcohol-and-bleomycin-with-finasteride-gavages-in-rats
#20
Ali Eslahi, Ali Noorafshan, Ali-Reza Safarpour, Masood Sepehrimanesh, Ali Ariafara, Elham Nadimi
INTRODUCTION: Resection of the prostate is one of the standard surgical treatments for symptomatic Benign Prostatic Hyperplasia (BPH). To evaluate minimally invasive treatments, intraprostatic injections of ethanol and bleomycin were compared with oral finasteride administration in rats with BPH. MATERIAL AND METHODS: The rats were divided into six groups. The control rats received no BPH/no treatment. BPH was induced using injections of testosterone (2 mg/day/rat for 4 weeks) in groups II-VI...
June 30, 2017: Central European Journal of Urology
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