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Benign prostatic hypertrophy

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https://www.readbyqxmd.com/read/28721283/stereological-comparison-of-intraprostatic-injection-of-alcohol-and-bleomycin-with-finasteride-gavages-in-rats
#1
Ali Eslahi, Ali Noorafshan, Ali-Reza Safarpour, Masood Sepehrimanesh, Ali Ariafara, Elham Nadimi
INTRODUCTION: Resection of the prostate is one of the standard surgical treatments for symptomatic Benign Prostatic Hyperplasia (BPH). To evaluate minimally invasive treatments, intraprostatic injections of ethanol and bleomycin were compared with oral finasteride administration in rats with BPH. MATERIAL AND METHODS: The rats were divided into six groups. The control rats received no BPH/no treatment. BPH was induced using injections of testosterone (2 mg/day/rat for 4 weeks) in groups II-VI...
June 30, 2017: Central European Journal of Urology
https://www.readbyqxmd.com/read/28694768/the-androgen-receptor-plays-different-roles-in-macrophage-induced-proliferation-in-prostate-stromal-cells-between-transitional-and-peripheral-zones-of-benign-prostatic-hypertrophy
#2
Dongliang Xu, Xingjie Wang, Chenyi Jiang, Yuan Ruan, Shujie Xia, Xiaohai Wang
Macrophages play a critical role in the process of excessive stromal proliferation of benign prostatic hyperplasia (BPH). In our previous study, we used a BPH mouse model to elucidate a potential mechanism whereby macrophage infiltration promotes stromal cell proliferation in the prostate via the androgen receptor (AR)/inflammatory cytokine CCL3-dependent pathway. In our present study, we used the co-culture system of human macrophages and various prostatic zone stromal cells to further demonstrate that infiltrating macrophages promote prostatic stromal cell proliferation through stromal AR-dependent pathways, and we show that the stroma of TZ and PZ respond to macrophages differently because of differences in stromal AR signaling; this could possibly be one of the key pathways for stromal expansion during BPH development and progression...
2017: EXCLI journal
https://www.readbyqxmd.com/read/28694142/increased-psa-expression-on-prostate-cancer-exosomes-in-in%C3%A2-vitro-condition-and-in-cancer-patients
#3
Mariantonia Logozzi, Daniela F Angelini, Elisabetta Iessi, Davide Mizzoni, Rossella Di Raimo, Cristina Federici, Luana Lugini, Giovanna Borsellino, Alessandro Gentilucci, Federico Pierella, Vittorio Marzio, Alessandro Sciarra, Luca Battistini, Stefano Fais
Prostate specific antigen (PSA) test is the most common, clinically validated test for the diagnosis of prostate cancer (PCa). While neoplastic lesions of the prostate may cause aberrant levels of PSA in the blood, the quantitation of free or complexed PSA poorly discriminates cancer patients from those developing benign lesions, often leading to invasive and unnecessary surgical procedures. Microenvironmental acidity increases exosome release by cancer cells. In this study we evaluated whether acidity, a critical phenotype of malignancy, could influence exosome release and increase the PSA expression in nanovesicles released by PCa cells...
July 8, 2017: Cancer Letters
https://www.readbyqxmd.com/read/28646943/state-of-the-art-advanced-techniques-for-prostatic-urethral-lift-for-the-relief-of-prostate-obstruction-under-local-anesthesia
#4
Lance Patrick Walsh
Benign prostatic hypertrophy (BPH) affects an estimated 60% of men over the age of 50 and 90% of men over the age of 80. The prostatic urethral lift (PUL) is a safe and effective office-based procedure that is used worldwide for the treatment of BPH in men who are dissatisfied with medications due to side effects or lack of efficacy or don't want to have a transurethral resection of the prostate due to the side effects and invasiveness of the procedure. In 2012 Barkin et al, published the standard technique for the delivery of the Urolift implant...
June 2017: Canadian Journal of Urology
https://www.readbyqxmd.com/read/28644156/clinical-case-of-the-month-a-57-year-old-man-with-an-axillary-mass
#5
Palak Desai, Andrew Myers, Brian Boulmay, Fred A Lopez
A 57-year-old man presented to the surgical oncology clinic with a mildly tender mass under his right arm. Four years prior, the patient had a melanoma removed from his right shoulder along with an ipsilateral right axillary sentinel lymph sampling. Computed tomography (CT) scan was negative for metastatic disease at that time. The patient did not undergo completion axillary node dissection and was lost to follow-up. The patient was originally from Australia, did not tan but reported multiple sunburns before age 18...
May 2017: Journal of the Louisiana State Medical Society: Official Organ of the Louisiana State Medical Society
https://www.readbyqxmd.com/read/28637364/comparison-of-perioperative-outcomes-between-holmium-laser-enucleation-of-the-prostate-and-robot-assisted-simple-prostatectomy
#6
Mimi W Zhang, Marawan M El Tayeb, Michael S Borofsky, Casey A Dauw, Kristofer R Wagner, Patrick S Lowry, Erin T Bird, Tillman C Hudson, James E Lingeman
OBJECTIVES: To compare perioperative outcomes for patients undergoing holmium laser enucleation of the prostate (HoLEP) and robotic-assisted simple prostatectomy (RSP) for benign prostatic hypertrophy (BPH). METHODS: Patient demographics and perioperative outcomes were compared between 600 patients undergoing HoLEP and 32 patients undergoing RSP at two separate academic institutions between 2008 and 2015. RESULTS: Patients undergoing HoLEP and RSP had comparable ages (71 vs 71, p = 0...
July 19, 2017: Journal of Endourology
https://www.readbyqxmd.com/read/28631905/-rationale-of-pharmacotherapy-duration-in-patients-with-benign-prostatic-hyperplasia-a-clinical-morphological-study
#7
M E Sitdykova, D E Tsyplakov, E N Sitdykov, A R Nurtdinov
AIM: To investigate the nature of morphological alterations in the urinary bladder wall in BPH patients receiving pharmacotherapy to establish treatment time limits. MATERIALS AND METHODS: The study comprised 120 BPH patients who underwent a transvesical adenomectomy. Prior to the surgery, 110 patients received pharmacotherapy (-blockers and 5-reductase inhibitors) lasting from 1-6 months to 5-10 years. Preoperative evaluation included a standard diagnostic algorithm...
June 2017: Urologii︠a︡
https://www.readbyqxmd.com/read/28609136/can-the-urolift-prostatic-implant-device-treat-the-symptoms-of-benign-prostatic-hypertrophy-avoid-sexual-dysfunction-and-reduce-hospital-turp-waiting-times-a-single-centre-single-surgeon-experience-and-review-of-the-literature
#8
Antonio D Bardoli, Will St J Taylor, Wasim Mahmalji
BPH associated with LUTS and sexual dysfunction is common. We performed UroLift on 11 patients, average age 71 years (range 56-90). IPSS improved by an average of 9 points post-procedure. Pre-operatively their post-void residuals were 306.3 ml (range 120-499 ml SD [120.6]) and their QMAX was 7 ml/s (range 4-14 SD [2.8] ml/s). Post-procedure the post-void residual decreased by 35.4% at 4 months (mean difference - 106.3 ml). QMAX improved by an average of 1.7 ml/s, which was not statistically significant...
June 13, 2017: Aging Male: the Official Journal of the International Society for the Study of the Aging Male
https://www.readbyqxmd.com/read/28593165/minimally-invasive-surgical-therapies-for-benign-prostatic-hypertrophy-the-rise-in-minimally-invasive-surgical-therapies
#9
REVIEW
Daniel Christidis, Shannon McGrath, Marlon Perera, Todd Manning, Damien Bolton, Nathan Lawrentschuk
The prevalence of benign prostatic hypertrophy (BPH) causing bothersome lower urinary tract symptoms increases with our ageing population. Treatment of BPH traditionally begins with medical therapy and surgical intervention is then considered for those whose symptoms progress despite treatment. Minimally invasive surgical therapies have been developed as an intermediary in the treatment of BPH with the aim of decreasing the invasiveness of interventions. These therapies also aim to reduce morbidity and dysfunction related to invasive surgical procedures...
June 2017: Prostate International
https://www.readbyqxmd.com/read/28576667/bipolar-plasma-enucleation-of-the-prostate-b-tuep-in-benign-prostate-hypertrophy-treatment-3-year-results
#10
Roberto Giulianelli, Barbara Cristina Gentile, Gabriella Mirabile, Luca Albanesi, Paola Tariciotti, Giorgio Rizzo, Maurizio Buscarini, Cristina Falavolti
OBJECTIVE: To numerous endoscopic techniques have been described for the treatment of benign prostate enlargement (BPE). The plasma-button enucleation of the prostate (B-TUEP) is a successful treatment option because the large surface creates a fast enucleation process, vaporization and concomitant haemostasis. The aim of this study was to evaluate the efficacy of bipolar button electrode transurethral adenoma enucleation (B-TUEP) in saline solution. The second endpoint was to determine the change of IPSS, PVR, IEFF-5, TrUS and PSA...
May 30, 2017: Urology
https://www.readbyqxmd.com/read/28540903/recurrent-syndrome-of-inappropriate-antidiuretic-hormone-secretion-due-to-tolterodine-in-an-elderly-male-patient
#11
Abdullah K Alhwiesh, Husain Alsharani, Eman Fathi Ibrahim, Zaid Alanazi, Bushra Ahmed AlGhamdi, Nadia Alaudah, Feras Alzahrani, Adnan Alsarawi, Ashwaqu Almohaws, Ibraheem Saeed Abdurrahman
Hyponatremia is defined as serum sodium of <135 mmol/L and equates with a low serum osmolality once translocational hyponatremia and pseudohyponatremia are ruled out. True hyponatremia develops when normal urine-diluting mechanisms are disturbed. In elderly patients, this complication is not uncommon, especially in nursing homes and assisted living facilities. Medications are often the most common cause of hyponatremia in these patients. Herewith, we reported a 65-year-old Saudi male, a known case of benign prostatic hypertrophy and hypertension, who developed recurrent hyponatremia secondary to tolterodine...
May 2017: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/28537696/electron-microscopic-changes-of-detrusor-in-benign-enlargement-of-prostate-and-its-clinical-correlation
#12
Sher Singh Yadav, Rohit Bhattar, Lokesh Sharma, Gautam Banga, Trilok Chandra Sadasukhi
AIMS: To study the ultra structural changes in bladder musculature in cases of BPE and their clinical relevance. MATERIAL AND METHODS: In this descriptive longitudinal, controlled, observational study patients were enrolled into three groups, group 1, group 2A and group 2B. Control group (group-1) consisted of age matched normal male patients, who underwent surveillance or diagnostic cystoscopy for microscopic hematuria or irritative symptoms. Case group (group-2) comprised of patients with BPE, undergoing TURP...
May 23, 2017: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/28506701/case-control-study-of-intraarterial-verapamil-for-intraprostatic-anastomoses-to-extraprostatic-arteries-in-prostatic-artery-embolization-for-benign-prostatic-hypertrophy
#13
Simon Chun Ho Yu, Carmen Cho, Esther Hung, Defeng Wang, Peter Chiu, Chi Hang Yee, Anthony Ng
PURPOSE: It is hypothesized that intraarterial administration of verapamil is a safe and effective way to reverse the flow in intraprostatic anastomoses to extraprostatic arteries without compromising treatment outcomes in prostatic artery embolization (PAE) for benign prostatic hypertrophy (BPH). MATERIALS AND METHODS: A prospective study of 62 prostate sides in 31 consecutive patients (median age, 66 y; range, 60-71 y) with symptomatic BPH was undertaken. Median prostate volume was 72...
May 13, 2017: Journal of Vascular and Interventional Radiology: JVIR
https://www.readbyqxmd.com/read/28487578/5%C3%AE-reductase-inhibitors-for-treatment-of-benign-prostatic-hyperplasia-a-systematic-review-and-meta-analysis
#14
REVIEW
Jennifer E J Jun, Angus Kinkade, Anthony C H Tung, Aaron M Tejani
BACKGROUND: Finasteride and dutasteride are competitive inhibitors of 5α-reductase enzymes and are commonly used to treat symptomatic benign prostatic hyperplasia (BPH). OBJECTIVE: To compare the efficacy and safety of finasteride and dutasteride in terms of clinically important outcomes. DATA SOURCES: A literature search was performed using the search terms "prostatic hyperplasia", "prostatic hypertrophy", "dutasteride", "finasteride", "quality of life", "adverse drug reaction", and "mortality"...
March 2017: Canadian Journal of Hospital Pharmacy
https://www.readbyqxmd.com/read/28435905/transurethral-resection-of-the-prostate-bladder-explosion-and-hyponatremic-encephalopathy-a-rare-case-report-of-malpractice
#15
Giuseppe Vacchiano, Aldo Rocca, Rita Compagna, Anna Ginevra Immacolata Zamboli, Vera Cirillo, Lorenza Di Domenico, Veronica Di Nardo, Giuseppe Servillo, Bruno Amato
We present an original case report of a bladder explosion during a TURP intervention for benign prostatic hypertrophy, that was brought on by the absorption of about 5 liters of glycine 1.5% and then onset of a severe hyponatremia. The quick and inappropriate correction of this electrolyte imbalance led the onset of encephalopathy and the death of the patient. The authors discuss the pathogenesis of these uncommon diseases and, considering the most recent Italian Legislation, they highlight the importance to respect good clinical practice standards and guidelines to ensure the most appropriate treatments for the patient and remove any assumptions of medical liability...
January 2017: Open Medicine (Warsaw, Poland)
https://www.readbyqxmd.com/read/28433616/investigating-the-link-between-benign-prostatic-hypertrophy-bmi-and-type-2-diabetes-mellitus
#16
B Shivananda Nayak, Khaleel Sinanan, Shivang Sharma, Vashista Shripat, Rukaiya Sidat, Safiyah Siddiqui, Niketa Sieunarine, Seymour Sieunarine
AIMS: To investigate the link between benign prostatic hypertrophy, BMI and type 2 diabetes mellitus. MATERIALS AND METHODS: This was the retrospective study conducted at the urology clinic of NCRHA and SWRHA, in Trinidad. Data was obtained from 85 patients with high PSA values (>4.0ng/mL). The data collected were age, ethnicity, weight, height, lifestyle and their most recent blood sugar levels were recorded. Ultrasound reports of patients diagnosed with BPH were also analyzed to gather data on whether their hyperplasia was benign or malignant...
April 15, 2017: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/28422991/mortality-is-associated-with-inflammation-anemia-specific-diseases-and-treatments-and-molecular-markers
#17
Mark Moeller, Christiane Pink, Nicole Endlich, Karlhans Endlich, Hans-Jörgen Grabe, Henry Völzke, Marcus Dörr, Matthias Nauck, Markus M Lerch, Rüdiger Köhling, Birte Holtfreter, Thomas Kocher, Georg Fuellen
Lifespan is a complex trait, and longitudinal data for humans are naturally scarce. We report the results of Cox regression and Pearson correlation analyses using data of the Study of Health in Pomerania (SHIP), with mortality data of 1518 participants (113 of which died), over a time span of more than 10 years. We found that in the Cox regression model based on the Bayesian information criterion, apart from chronological age of the participant, six baseline variables were considerably associated with higher mortality rates: smoking, mean attachment loss (i...
2017: PloS One
https://www.readbyqxmd.com/read/28422535/comparison-between-normal-saline-and-ringer-s-acetate-in-bipolar-transurethral-resection-of-the-prostate
#18
Ehab Ahmed, Jacob Ingvar, Claes R Nyman, Ulf Norming, Emma Andersson, Robert G Hahn, Tim Fagerström
OBJECTIVE: The standard surgical treatment for benign prostatic hypertrophy (BPH) is transurethral resection of the prostate (TURP). The aim of this study was to compare normal saline (NS) (0.9% sodium chloride) and Ringer's acetate (RA) as irrigation fluid with regard to visibility, resection feasibility, coagulation and bleeding in bipolar TURP. MATERIALS AND METHODS: Twenty patients (mean age 70 years) who were diagnosed with BPH were recruited to the study. The first three 3 liter bags of irrigation fluid contained either NS or RA and were administered in a randomized fashion...
April 19, 2017: Scandinavian Journal of Urology
https://www.readbyqxmd.com/read/28392430/-prospective-evaluation-of-the-direct-costs-of-prostate-enucleation-by-the-holep-%C3%A2-laser-during-the-learning-curve-period
#19
M Roger, M Goris-Gbenou, A Guillermet, R Vial, N Cunin, J Tomas, L Bourgue, M Combe, J-G Lopez, C Combe
OBJECTIVE: Holmium laser enucleation of the prostate (HoLEP) has been shown to be effective in treating large prostates compared to prostate transurethral resection (TURP). There are no published data evaluating specifically the impact of the learning curve on the direct costs of HoLEP. The objective of this study was to evaluate the direct costs generated by the use of HoLEP laser during the learning curve period. METHOD: The costs of all medical devices (DM) and drugs used, pre- and post-operative parameters during surgery have been prospectively collected between March and October 2016...
April 6, 2017: Progrès en Urologie
https://www.readbyqxmd.com/read/28351489/dying-for-love-perimenopausal-degeneration-of-vaginal-microbiome-drives-the-chronic-inflammation-malignant-transformation-of-benign-prostatic-hyperplasia-to-prostatic-adenocarcinoma
#20
Albert Stuart Reece
Prostatic carcinoma is the second commonest cancer in males and is so common as to become almost holoendemic with advancing age. The recent demonstration that far from being benign, "benign" prostatic hypertrophy is a likely a reaction of the prostate to chronic untreated lower genital tract infection, and that this chronic inflammation is likely the usual precursor to the frequent occurrence of prostatic carcinoma has far reaching implications. The obvious source for the chronic inflammatory stimulus in the prostate is the documented dramatically altered lower female genital microbiota associated with the menopause...
April 2017: Medical Hypotheses
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