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Benign prostatic hypertrophy

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https://www.readbyqxmd.com/read/27876713/role-of-acoustic-radiation-force-impulse-arfi-elastography-in-determination-of-severity-of-benign-prostate-hyperplasia
#1
Bircan Alan, Mazhar Utangaç, Cemil Göya, Mansur Dağgülli
BACKGROUND The aim of this study was to investigate the potential contribution of acoustic radiation force impulse (ARFI) elastography to the determination of the severity of benign prostate hypertrophy (BPH) by performing shear wave velocity (SWV) measurements of the prostate using ARFI technology. MATERIAL AND METHODS Sixty BPH patients and 40 healthy volunteers were included in this study. SWV measurements of the prostate were performed by transabdominal ultrasonography (US), both in the BPH patients and control subjects...
November 23, 2016: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/27853823/prostate-artery-embolization-for-complete-urinary-outflow-obstruction-due-to-benign-prostatic-hypertrophy
#2
Simon Chun Ho Yu, Carmen Chi Min Cho, Esther Hiu Yee Hung, Peter Ka Fung Chiu, Chi Hang Yee, Chi Fai Ng
BACKGROUND: We aimed to evaluate the effectiveness of PAE in weaning of catheter and relieving obstructive urinary symptoms in patients with acute urinary retention (AUR) due to benign prostatic hypertrophy (BPH) and failed trial without catheter (TWOC). MATERIALS AND METHODS: In this prospective study approved by the institutional review board, a signed informed consent was obtained. Eighteen consecutive patients with AUR due to BPH and failed TWOC were recruited...
November 16, 2016: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/27845695/-prognostic-factors-for-the-efficacy-of-silodosin-in-the-treatment-of-symptomatic-benign-prostatic-hyperplasia-subanalysis-of-the-ural-study
#3
Jesús Salinas-Casado, Miguel Vírseda-Chamorro, Santiago Méndez-Rubio, Marcos Luján-Galán, Manuel Esteban-Fuertes, Jesús Moreno-Sierra
OBJECTIVE: To identify the prognostic factors influencing the clinical and urodynamics results on symptomatic benign prostatic hypertrophy (BHP) treatment in a series of patients with silodosin therapy from the URAL study. METHODS: A retrospective study was performed in a cohort of 318 patients with BPH which underwent silodosine treatment, during at least 12 weeks. RESULTS: Univariate analysis demonstrated that the variables in relationship with a decrease of urinary symptoms` punctuation postreatment (measured with the IPSS Questionnaire), a maximum peak flow (Q max) postreatment equal or superior to 15 ml/s, a postreatment postvoid residual lower to 100 ml, and a postreatment obstruction index ( Bladder Outlet Obstruction Index: BOOI) equal or lower to 20 cm H2O, presented such both as a clinical and urodynamic character...
November 2016: Archivos Españoles de Urología
https://www.readbyqxmd.com/read/27812496/reversible-exacerbation-of-obstructive-sleep-apnea-by-%C3%AE-1-adrenergic-blockade-with-tamsulosin-a-case-report
#4
Mark Moran
: Obstructive sleep apnea (OSA) is characterized by repeated involuntary closure of the pharyngeal airspace during sleep. Normal activity of the genioglossus (GG) muscle is important in maintaining airway patency, and inhibition of GG activity can contribute to airway closure. Neurons in the hypoglossal motor nucleus (HMN) regulate GG activity. Adrenergic tone is an important regulator of HMN neuronal excitability. In laboratory models α1-adrenergic antagonists inhibit HMN neurons and GG activity, suggesting that α1-adrenergic antagonism might adversely affect patients with OSA...
2016: Respiratory Medicine Case Reports
https://www.readbyqxmd.com/read/27805334/nocturia-symptom-or-a-disease
#5
REVIEW
Vyas Narayana Rao, Ganesh Gopalakrishnan, Ajit Saxena, Hemant Pathak, Divakar Dalela, Shailesh Shah, Mallikarjuna Reddy, Prasanna Kumar Mishra, Harshad Malve
Waking at night to void is known as nocturia and it is a common condition experienced by both men and women with profound impact on patient's health, quality of life, and economic condition. It is often perceived as a symptom of an organic disease, but the pathophysiology of nocturia is now well-understood, and it is considered as a disease itself. It is classified based on four different pathophysiologic mechanisms (24-hour polyuria, nocturnal polyuria, reduced bladder capacity, and sleep disorders). The association of nocturia with impaired quality of life, cardiovascular morbidity and all-cause mortality is well established...
November 2016: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/27767680/postoperative-urinary-retention-in-patients-undergoing-elective-spinal-surgery
#6
David Altschul, Andrew Kobets, Jonathan Nakhla, Ajit Jada, Rani Nasser, Merritt D Kinon, Reza Yassari, John Houten
OBJECTIVE Postoperative urinary retention (POUR) is a common problem leading to morbidity and an increased hospital stay. There are limited data regarding its baseline incidence in patients undergoing spinal surgery and the risk factors with which it may be associated. The purpose of this study was to evaluate the incidence of POUR in elective spine surgery patients and determine the factors associated with its occurrence. METHODS The authors retrospectively reviewed the records of patients who had undergone elective spine surgery and had been prospectively monitored for POUR during an 18-month period...
October 21, 2016: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/27709382/effect-of-doxazosin-on-autonomic-nervous-control-and-urodynamics-of-rat-urinary-bladder-during-modeled-infravesical-obstruction
#7
V I Kirpatovskii, I S Mudraya, S V Revenko, A Yu Bablumyan, N K Adamyan, V P Ivanov
The therapeutic effect of doxazosin (40 μg/kg/day over one month) on urinary bladder was examined in female rats with modeled chronic infravesical obstruction (IVO) produced by graduated mechanical constriction of the proximal urethral segment. In one month, IVO induced a pronounced vesical hypertrophy both in treated and untreated rats that manifested in increased bladder weight and capacity, the latter increment being pronouncedly greater in treated rats. In untreated IVO rats, infusion cystometry revealed elevated basal intravesical pressure of void bladder P0, markedly increased maximal (premicturitional) pressure Pmax, and increased amplitude of spontaneous oscillations of intravesical pressure ΔPdet in filled bladder...
September 2016: Bulletin of Experimental Biology and Medicine
https://www.readbyqxmd.com/read/27629686/treatment-of-lower-urinary-tract-symptoms-in-benign-prostatic-hypertrophy-with-%C3%AE-blockers
#8
Mathieos Belayneh, Christina Korownyk
No abstract text is available yet for this article.
September 2016: Canadian Family Physician Médecin de Famille Canadien
https://www.readbyqxmd.com/read/27580828/relationship-among-diet-habit-and-lower-urinary-tract-symptoms-and-sexual-function-in-outpatient-based-males-with-luts-bph-a-multiregional-and-cross-sectional-study-in-china
#9
Yuke Chen, Wei Yu, Liqun Zhou, Shiliang Wu, Yang Yang, Jianye Wang, Ye Tian, Dalin He, Yong Xu, Jian Huang, Xiaofeng Wang, Xin Gao, Hanzhong Li, Lulin Ma, Ning Zhang, Shengtian Zhao, Xunbo Jin
OBJECTIVES: This study assessed the effect of diet habits on lower urinary tract symptoms (LUTS) and sexual function in Chinese men with LUTS/benign prostatic hypertrophy (LUTS/BPH). SETTING: Multicentre study conducted between July 2013 and December 2013 in 11 hospitals in 3 geographic regions in China. PARTICIPANTS: Overall, participants with LUTS/BPH accounted for 61.4% (2584/4208) of the respondents, whose data were processed in the following statistical analysis...
2016: BMJ Open
https://www.readbyqxmd.com/read/27576558/sudden-occurence-of-hypotension-and-bradycardia-during-greenlight-laser-transurethral-resection-of-prostate-case-report-of-two-cases
#10
Zheng Guan, Jingjie Liu
BACKGROUND: Greenlight laser transurethral resection of prostate (TURP) is a standard surgical method used to treat patients with prostate gland enlargement, it is safe and effective. CASE PRESENTATION: We report two cases of sudden occurence of hypotension and bradycardia during greenlight laser TURP. Two patients with benign prostatic hypertrophy were scheduled for greenlight laser TURP under spinal anesthesia. Hypotension and bradycardia were suddenly occurred during the operation...
2016: BMC Anesthesiology
https://www.readbyqxmd.com/read/27563517/the-effect-of-bongardia-chrysogonum-on-prostate-tissue-in-a-rat-model-of-stz-induced-diabetes
#11
Recep Dokuyucu, Kerem Han Gozukara, Oguzhan Ozcan, Nebihat Kaplan Sefil, Ahmet Nacar, Ahmet Dokuyucu, Mehmet Inci
BACKGROUND: Bongardia chrysogonum is widely used in Turkey for treating urinary tract infections and prostate hypertrophy, and it also has potent hypoglycemic effects and aids glucose homeostasis. Because of the inflammatory conditions in diabetes mellitus (DM), the prostate tissue of men with diabetes is particularly susceptible to developing hypoplasia, and DM produces characteristic pathological changes in prostate tissue. Here, we examined the effects of B. chrysogonum on the prostate tissue of rats with streptozotocin (STZ)-induced diabetes...
2016: SpringerPlus
https://www.readbyqxmd.com/read/27535076/management-of-benign-prostatic-hyperplasia-in-older-adults
#12
Todd J Woodard, Kendra R Manigault, Niesha N McBurrows, Tiffany L Wray, Laresa M Woodard
Benign prostatic hyperplasia (BPH), also known as benign prostatic hypertrophy, is a nonmalignant adenomatous overgrowth of the periurethral prostate gland commonly seen in aging men. Historically, it has been assumed that the pathophysiology of lower urinary tract symptoms in men is the result of bladder outlet obstruction associated with prostate enlargement. Symptoms such as urinary hesitancy, incomplete bladder emptying, dribbling or prolonged urination, nocturia, urinary urgency, and/or urge incontinence are common...
2016: Consultant Pharmacist: the Journal of the American Society of Consultant Pharmacists
https://www.readbyqxmd.com/read/27427862/serum-25-oh-d-seasonality-in-urologic-patients-from-central-italy
#13
Alessia Calgani, Marco Iarlori, Vincenzo Rizi, Gianna Pace, Mauro Bologna, Carlo Vicentini, Adriano Angelucci
Hypovitaminosis D is increasingly recognized as a cofactor in several diseases. In addition to bone homeostasis, vitamin D status influences immune system, muscle activity and cell differentiation in different tissues. Vitamin D is produced in the skin upon exposure to UVB rays, and sufficient levels of serum 25(OH)D are dependent mostly on adequate sun exposure, and then on specific physiologic variables, including skin type, age and Body Mass Index (BMI). In contrast with common belief, epidemiologic data are demonstrating that hypovitaminosis D must be a clinical concern not only in northern Countries...
September 2016: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/27406644/prostate-specific-antigen-testing-in-inner-london-general-practices-are-those-at-higher-risk-most-likely-to-get-tested
#14
Paul Nderitu, Mieke Van Hemelrijck, Mark Ashworth, Rohini Mathur, Sally Hull, Alexandra Dudek, Simon Chowdhury
OBJECTIVES: To investigate the association between factors influencing prostate-specific antigen (PSA) testing prevalence including prostate cancer risk factors (age, ethnicity, obesity) and non-risk factors (social deprivation and comorbidity). SETTING: A cross-sectional database of 136 inner London general practices from 1 August 2009 to 31 July 2014. PARTICIPANTS: Men aged ≥40 years without prostate cancer were included (n=150 481)...
2016: BMJ Open
https://www.readbyqxmd.com/read/27399661/inhibitory-activities-of-phenolic-compounds-isolated-from-adina-rubella-leaves-against-5%C3%AE-reductase-associated-with-benign-prostatic-hypertrophy
#15
Jun Yin, Jun Hyeok Heo, Yoon Jeong Hwang, Thi Tam Le, Min Won Lee
Adina rubella Hance (AR), a plant native to Korea, has been used as traditional medicine for dysentery, eczema, intoxication, and external hemorrhages. Previous phytochemical studies of AR have reported several components, including terpenoids, phenolics, and alkaloids. The current study evaluated the anti-oxidative and anti-inflammatory activities and 5α-reductase inhibition of isolated compounds of AR leaves to find a potential therapeutic agent for benign prostatic hypertrophy (BPH). Repeated chromatographic isolation of an 80% acetone extract of AR leaves yielded seven phenolic compounds: caffeic acid (1), chlorogenic acid (2), methyl chlorogenate (3), quercetin-3-rutinoside (4), kaempferol-3-O-α-l-rhamnopyranosyl-(1→6)-β-d-glucopyranoside (5), hyperoside (6), and grandifloroside (7)...
2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27398244/the-wonders-of-phosphodiesterase-5-inhibitors-a-majestic-history
#16
REVIEW
A S Elhwuegi
The Nobel Prize winning discovery of nitric oxide (NO) in 1986 was the starting point for a new innovation in drug discovery. NO acting as a mediator at different physiological systems is believed to be involved in many physiological and pathological conditions through the formation of the second messenger cyclic guanosine monophosphate (cGMP). cGMP-dependent vasodilation effect of NO is important in regulating pulmonary and systemic pressures, maintaining penis erection, preventing atherosclerosis, preventing platelet aggregation, and protecting and controlling cardiac functions...
May 2016: Annals of Medical and Health Sciences Research
https://www.readbyqxmd.com/read/27386051/finasteride-in-hidradenitis-suppurativa-a-male-therapy-for-a-predominantly-female-disease
#17
REVIEW
Birgit N Khandalavala, Melissa Voutsalath Do
OBJECTIVE: Hidradenitis suppurativa is associated with obesity and metabolic syndrome, and a hormonal component has been implicated. Finasteride is an anti-androgenic agent used for benign prostatic hypertrophy, androgenic alopecia, and, in females, hirsutism. Finasteride is an inhibitor of type II5 alpha-reductase that reduces dihydrotestosterone levels and appears to alter end-organ sensitivity of the folliculopilosebaceous unit. The objective is to review the use of finasteride for hidradenitis suppurativa...
June 2016: Journal of Clinical and Aesthetic Dermatology
https://www.readbyqxmd.com/read/27376653/drug-interactions-between-antiretrovirals-and-drugs-used-to-treat-benign-prostatic-hyperplasia-lower-urinary-tract-symptoms
#18
Denise Kreutzwiser, Alice Tseng
INTRODUCTION: Significant advances in antiretroviral (ARV) therapy have transformed HIV into a chronic manageable disease. Co-morbidities associated with aging, such as benign prostatic hyperplasia (BPH), are becoming increasingly prevalent in the HIV-infected population. The pharmacological treatment of BPH involves medications mainly metabolized by CYP 450 enzymes, while many ARVs have inducing or inhibiting effects on the CYP 450 system. Consequently, there is potential for significant pharmacokinetic (PK) interactions between these two classes of medications...
October 2016: Expert Opinion on Drug Metabolism & Toxicology
https://www.readbyqxmd.com/read/27321530/re-stroke-associated-with-alpha-blocker-therapy-for-benign-prostatic-hypertrophy
#19
Steven A Kaplan
No abstract text is available yet for this article.
July 2016: Journal of Urology
https://www.readbyqxmd.com/read/27298504/atypical-post-finasteride-syndrome-a-pharmacological-riddle
#20
Anita K Gupta, Neetu Sharma, Prashant Shukla
Finasteride and dutasteride are commonly used 5-alpha reductase inhibitors. While finasteride is a selective inhibitor of 5-alpha reductase Type II, dutasteride inhibits 5- alpha reductase Type I and II. The United States Food and Drug Administration approved the use of finasteride for benign prostatic hypertrophy (BPH) as well as androgenic alopecia (AGA) while dutasteride is approved only for BPH. Off-label use of dutasteride is not uncommon in AGA as well. Although the postfinasteride syndrome (PFS) is a well-established entity, its symptomatology is quite variable...
May 2016: Indian Journal of Pharmacology
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