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Benign prostatic hypertrophy

V I Kirpatovskii, I S Mudraya, S V Revenko, A Yu Bablumyan, N K Adamyan, V P Ivanov
The therapeutic effect of doxazosin (40 μg/kg/day over one month) on urinary bladder was examined in female rats with modeled chronic infravesical obstruction (IVO) produced by graduated mechanical constriction of the proximal urethral segment. In one month, IVO induced a pronounced vesical hypertrophy both in treated and untreated rats that manifested in increased bladder weight and capacity, the latter increment being pronouncedly greater in treated rats. In untreated IVO rats, infusion cystometry revealed elevated basal intravesical pressure of void bladder P0, markedly increased maximal (premicturitional) pressure Pmax, and increased amplitude of spontaneous oscillations of intravesical pressure ΔPdet in filled bladder...
September 2016: Bulletin of Experimental Biology and Medicine
Mathieos Belayneh, Christina Korownyk
No abstract text is available yet for this article.
September 2016: Canadian Family Physician Médecin de Famille Canadien
Yuke Chen, Wei Yu, Liqun Zhou, Shiliang Wu, Yang Yang, Jianye Wang, Ye Tian, Dalin He, Yong Xu, Jian Huang, Xiaofeng Wang, Xin Gao, Hanzhong Li, Lulin Ma, Ning Zhang, Shengtian Zhao, Xunbo Jin
OBJECTIVES: This study assessed the effect of diet habits on lower urinary tract symptoms (LUTS) and sexual function in Chinese men with LUTS/benign prostatic hypertrophy (LUTS/BPH). SETTING: Multicentre study conducted between July 2013 and December 2013 in 11 hospitals in 3 geographic regions in China. PARTICIPANTS: Overall, participants with LUTS/BPH accounted for 61.4% (2584/4208) of the respondents, whose data were processed in the following statistical analysis...
2016: BMJ Open
Zheng Guan, Jingjie Liu
BACKGROUND: Greenlight laser transurethral resection of prostate (TURP) is a standard surgical method used to treat patients with prostate gland enlargement, it is safe and effective. CASE PRESENTATION: We report two cases of sudden occurence of hypotension and bradycardia during greenlight laser TURP. Two patients with benign prostatic hypertrophy were scheduled for greenlight laser TURP under spinal anesthesia. Hypotension and bradycardia were suddenly occurred during the operation...
2016: BMC Anesthesiology
Recep Dokuyucu, Kerem Han Gozukara, Oguzhan Ozcan, Nebihat Kaplan Sefil, Ahmet Nacar, Ahmet Dokuyucu, Mehmet Inci
BACKGROUND: Bongardia chrysogonum is widely used in Turkey for treating urinary tract infections and prostate hypertrophy, and it also has potent hypoglycemic effects and aids glucose homeostasis. Because of the inflammatory conditions in diabetes mellitus (DM), the prostate tissue of men with diabetes is particularly susceptible to developing hypoplasia, and DM produces characteristic pathological changes in prostate tissue. Here, we examined the effects of B. chrysogonum on the prostate tissue of rats with streptozotocin (STZ)-induced diabetes...
2016: SpringerPlus
Todd J Woodard, Kendra R Manigault, Niesha N McBurrows, Tiffany L Wray, Laresa M Woodard
Benign prostatic hyperplasia (BPH), also known as benign prostatic hypertrophy, is a nonmalignant adenomatous overgrowth of the periurethral prostate gland commonly seen in aging men. Historically, it has been assumed that the pathophysiology of lower urinary tract symptoms in men is the result of bladder outlet obstruction associated with prostate enlargement. Symptoms such as urinary hesitancy, incomplete bladder emptying, dribbling or prolonged urination, nocturia, urinary urgency, and/or urge incontinence are common...
2016: Consultant Pharmacist: the Journal of the American Society of Consultant Pharmacists
Alessia Calgani, Marco Iarlori, Vincenzo Rizi, Gianna Pace, Mauro Bologna, Carlo Vicentini, Adriano Angelucci
Hypovitaminosis D is increasingly recognized as a cofactor in several diseases. In addition to bone homeostasis, vitamin D status influences immune system, muscle activity and cell differentiation in different tissues. Vitamin D is produced in the skin upon exposure to UVB rays, and sufficient levels of serum 25(OH)D are dependent mostly on adequate sun exposure, and then on specific physiologic variables, including skin type, age and Body Mass Index (BMI). In contrast with common belief, epidemiologic data are demonstrating that hypovitaminosis D must be a clinical concern not only in northern Countries...
September 2016: Journal of Photochemistry and Photobiology. B, Biology
Paul Nderitu, Mieke Van Hemelrijck, Mark Ashworth, Rohini Mathur, Sally Hull, Alexandra Dudek, Simon Chowdhury
OBJECTIVES: To investigate the association between factors influencing prostate-specific antigen (PSA) testing prevalence including prostate cancer risk factors (age, ethnicity, obesity) and non-risk factors (social deprivation and comorbidity). SETTING: A cross-sectional database of 136 inner London general practices from 1 August 2009 to 31 July 2014. PARTICIPANTS: Men aged ≥40 years without prostate cancer were included (n=150 481)...
2016: BMJ Open
Jun Yin, Jun Hyeok Heo, Yoon Jeong Hwang, Thi Tam Le, Min Won Lee
Adina rubella Hance (AR), a plant native to Korea, has been used as traditional medicine for dysentery, eczema, intoxication, and external hemorrhages. Previous phytochemical studies of AR have reported several components, including terpenoids, phenolics, and alkaloids. The current study evaluated the anti-oxidative and anti-inflammatory activities and 5α-reductase inhibition of isolated compounds of AR leaves to find a potential therapeutic agent for benign prostatic hypertrophy (BPH). Repeated chromatographic isolation of an 80% acetone extract of AR leaves yielded seven phenolic compounds: caffeic acid (1), chlorogenic acid (2), methyl chlorogenate (3), quercetin-3-rutinoside (4), kaempferol-3-O-α-l-rhamnopyranosyl-(1→6)-β-d-glucopyranoside (5), hyperoside (6), and grandifloroside (7)...
2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
A S Elhwuegi
The Nobel Prize winning discovery of nitric oxide (NO) in 1986 was the starting point for a new innovation in drug discovery. NO acting as a mediator at different physiological systems is believed to be involved in many physiological and pathological conditions through the formation of the second messenger cyclic guanosine monophosphate (cGMP). cGMP-dependent vasodilation effect of NO is important in regulating pulmonary and systemic pressures, maintaining penis erection, preventing atherosclerosis, preventing platelet aggregation, and protecting and controlling cardiac functions...
May 2016: Annals of Medical and Health Sciences Research
Birgit N Khandalavala, Melissa Voutsalath Do
OBJECTIVE: Hidradenitis suppurativa is associated with obesity and metabolic syndrome, and a hormonal component has been implicated. Finasteride is an anti-androgenic agent used for benign prostatic hypertrophy, androgenic alopecia, and, in females, hirsutism. Finasteride is an inhibitor of type II5 alpha-reductase that reduces dihydrotestosterone levels and appears to alter end-organ sensitivity of the folliculopilosebaceous unit. The objective is to review the use of finasteride for hidradenitis suppurativa...
June 2016: Journal of Clinical and Aesthetic Dermatology
Denise Kreutzwiser, Alice Tseng
INTRODUCTION: Significant advances in antiretroviral (ARV) therapy have transformed HIV into a chronic manageable disease. Co-morbidities associated with aging, such as benign prostatic hyperplasia (BPH), are becoming increasingly prevalent in the HIV-infected population. The pharmacological treatment of BPH involves medications mainly metabolized by CYP 450 enzymes, while many ARVs have inducing or inhibiting effects on the CYP 450 system. Consequently, there is potential for significant pharmacokinetic (PK) interactions between these two classes of medications...
October 2016: Expert Opinion on Drug Metabolism & Toxicology
Steven A Kaplan
No abstract text is available yet for this article.
July 2016: Journal of Urology
Anita K Gupta, Neetu Sharma, Prashant Shukla
Finasteride and dutasteride are commonly used 5-alpha reductase inhibitors. While finasteride is a selective inhibitor of 5-alpha reductase Type II, dutasteride inhibits 5- alpha reductase Type I and II. The United States Food and Drug Administration approved the use of finasteride for benign prostatic hypertrophy (BPH) as well as androgenic alopecia (AGA) while dutasteride is approved only for BPH. Off-label use of dutasteride is not uncommon in AGA as well. Although the postfinasteride syndrome (PFS) is a well-established entity, its symptomatology is quite variable...
May 2016: Indian Journal of Pharmacology
Jessica Mandeville, Arthur Mourtzinos
Benign prostatic hypertrophy (BPH) is a common cause of voiding dysfunction. BPH may lead to bladder outlet obstruction and resultant troublesome lower urinary tract symptoms. Initial management of BPH and bladder outlet obstruction is typically conservative. However, when symptoms are severe or refractory to medical therapy or when urinary retention, bladder stone formation, recurrent urinary tract infections, or upper urinary tract deterioration occur, surgical intervention is often necessary. Numerous options are available for surgical management of BPH ranging from simple office-based procedures to transurethral operative procedures and even open and robotic surgeries...
June 2016: Surgical Clinics of North America
Marie Patrice Halle, Linda Njonkam Toukep, Samuel Ekane Nzuobontane, Hermine Fouda Ebana, Gregory Halle Ekane, Eugene Belley Priso
INTRODUCTION: Obstructive uropathy can lead to irreversible kidney damage. The etiology largely determined by the patient's age can be benign or malignant. This study aimed at determining the profile and outcome of patients with obstructive uropathy in Cameroon. METHODS: A cross sectional study carried out in the urology unit of the Douala General Hospital, including patients with a diagnosis of obstructive uropathy seen from January 2004 to December 2013. Clinical profile, treatment and outcome data were obtained from patients records...
2016: Pan African Medical Journal
Ravikumar Aalinkeel, Bindukumar Nair, Chih-Kuang Chen, Supriya D Mahajan, Jessica L Reynolds, Hanguang Zhang, Haotian Sun, Donald E Sykes, Kailash C Chadha, Steven G Turowski, Katelyn D Bothwell, Mukund Seshadri, Chong Cheng, Stanley A Schwartz
Interleukin-8 (IL-8) is a pro-angiogenic cytokine associated with aggressive prostate cancer (CaP). We detected high levels of IL-8 in sera from patients with CaP compared with healthy controls and patients with benign prostatic hypertrophy. This study examines the role of IL-8 in the pathogenesis of metastatic prostate cancer. We developed a biocompatible, cationic polylactide (CPLA) nanocarrier to complex with and efficiently deliver IL-8 small interfering RNA (siRNA) to CaP cells in vitro and in vivo. CPLA IL-8 siRNA nanocomplexes (nanoplexes) protect siRNA from rapid degradation, are non-toxic, have a prolonged lifetime in circulation, and their net positive charge facilitates penetration of cell membranes and subsequent intracellular trafficking...
August 2016: Immunology
Basri Cakiroglu, Aydin Ismet Hazar, Seyit Erkan Eyyupoglu, Mustafa Bahadir Can Balci, Orhun Sinanoglu, Pinar Tuzlali
INTRODUCTION: Organisms are constantly in a balance meaning that while new cells are produced, some of the older ones die which takes place in 2 ways: necrosis or apoptosis. Apoptosis is the programmed cellular death triggered by intrinsic or extrinsic stimuli. In this study we have evaluated the apoptosis of prostate tissue generated by surgical or medical orchiectomy. MATERIAL AND METHOD: In this experimental study, we used 36 adult male rats that were evaluated in 3 groups...
December 2015: Archivio Italiano di Urologia, Andrologia
Y Gao, X H Liao, L Lu, L Wang, Y Ma, H Z Qin, X Yan, P Guo
AIM: To evaluate the diagnostic accuracy of contrast-enhanced transrectal ultrasonography (CE-TRUS) versus baseline TRUS (combination of grey-scale and colour Doppler imaging) for diffuse prostate cancer. MATERIALS AND METHODS: Forty-six patients without an obvious focal mass on baseline TRUS (grey-scale and colour Doppler), underwent additional CE-TRUS and TRUS-guided biopsy due to elevated levels of prostate-specific antigen (PSA ≥4 ng/ml) and/or abnormal digital rectal examination (DRE)...
March 2016: Clinical Radiology
Yoshiaki Kawamura, Masatoshi Tokunaga, Hideaki Hoshino, Kazuo Matsushita, Toshiro Terachi
OBJECTIVE: This study compared outcomes of transurethral enucleation with bipolar (TUEB) with transurethral resection in saline (TURis). METHODS: Thirty patients who underwent TURis were compared with 30 who underwent TUEB. Perioperative treatment outcomes, preoperative and 1-month postoperative International Prostrate Symptom Scores (IPSS), quality of life (QOL) index, maximum flow rate, average urinary flow, post- void residual urinary volume, and complications were compared...
December 2015: Tokai Journal of Experimental and Clinical Medicine
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