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Benign prostatic hypertrophy

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https://www.readbyqxmd.com/read/29048765/ageratum-conyzoides-l-inhibits-5-alpha-reductase-gene-expression-in-human-prostate-cells-and-reduces-symptoms-of-benign-prostatic-hypertrophy-in-otherwise-healthy-men-in-a-double-blind-randomized-placebo-controlled-clinical-study
#1
Matthew Detering, Elizabeth Steels, Sundar Rao Koyyalamudi, Elena Allifranchini, Elena Bocchietto, Luis Vitetta
A double-blind, randomized, placebo-controlled clinical trial assessed the efficacy and safety of Ageratum conyzoides in treating benign prostatic hypertrophy (BPH). In this study, 109 men with medically diagnosed BPH, aged 41-76 years, were administered the investigational product, A. conyzoides extract at a dose of 250 mg/d or placebo, q.d. for 12 weeks. The primary outcome measures were the International Prostate Symptom Score (IPSS), daily urinary frequency and safety evaluations. The secondary outcome measures were testosterone, dihydrotestosterone, oestradiol, sex hormone binding globulin (SHBG), Dehydroepiandrosterone sulfate (DHEA-S) and cortisol levels, and prostate specific antigen (PSA), lipids, blood glucose, the Aging Male's Symptom (AMS) Score and sexual function assessed by Derogatis Interview for Sexual Functioning-Self Report (DISF-SR)...
October 19, 2017: BioFactors
https://www.readbyqxmd.com/read/28894411/bilateral-hydroureteronephrosis-with-a-hypertrophied-trabeculated-urinary-bladder
#2
Showkathali Iqbal, Iqbal Raiz, Iqbal Faiz
Bilateral hydroureteronephrosis involves the dilatation of the renal pelvis, calyces and ureter; it develops secondary to urinary tract obstruction and leads to a build-up of back pressure in the urinary tract, and it may lead to impairment of renal function and ultimately culminate in renal failure. Although clinically silent in most cases, it can be diagnosed as an incidental finding during evaluation of an unrelated cause. In a minority of patients, it presents with signs and symptoms. Renal calculus is the most common cause, but there are multiple non-calculus aetiologies, and they depend on age and sex...
March 2017: Malaysian Journal of Medical Sciences: MJMS
https://www.readbyqxmd.com/read/28856711/rationale-and-design-of-the-canari-study-a-case-control-study-investigating-the-association-between-prostate-cancer-and-5-alpha-reductase-inhibitors-for-symptomatic-benign-prostate-hypertrophy-by-linking-sniiram-and-pathology-laboratories-in-a-specific-region
#3
Lucie-Marie Scailteux, Frédéric Balusson, Sébastien Vincendeau, Nathalie Rioux-Leclercq, Emmanuel Nowak
Benign prostate hypertrophy (BPH) could be associated with low urinary symptoms requiring medical treatment: 5 alpha-reductase inhibitors (5-ARI) or ɑ-blockers. Two clinical trials investigating 5-ARI use in prostate cancer (PCa) primary prevention highlighted a potential safety signal with an increased risk of high grade PCa. Later observational studies failed to show similar results but have some limits. The present paper focuses on describing the protocol of the CANARI study and its feasibility, as regards the matching process of two pseudo-anonymous databases...
August 30, 2017: Fundamental & Clinical Pharmacology
https://www.readbyqxmd.com/read/28853814/magnetic-resonance-imaging-and-clinical-findings-in-seminal-vesicle-pathologies
#4
Zafer Ozmen, Fatma Aktas, Nihat Uluocak, Eda Albayrak, Ayşegül Altunkaş, Fatih Çelikyay
PURPOSE: Congenital and acquired pathologies of the seminal vesicles (SV) are rare diseases. The diagnosis of SV anomalies is frequently delayed or wrong due to the rarity of these diseases and the lack of adequate evaluation of SV pathology. For this reason, we aimed to comprehensively evaluate SV pathologies and accompanying genitourinary system abnormalities. MATERIALS AND METHODS: Between March 2012 and December 2015, 1455 male patients with different provisional diagnosis underwent MRI...
August 30, 2017: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/28845321/evaluation-of-anterior-segment-changes-of-patients-taking-alpha1-blockers-by-ultrasound-biomicroscopy-in-the-drug-free-period
#5
Yeliz Acar, Kadir Eltutar, Sibel Zırtıloğlu
OBJECTIVES: To evaluate and compare anterior segment changes in patients taking alpha-1 (α1) blockers (tamsulosin, terazosin, doxazosin, alfuzosin) for benign prostatic hypertrophy, during drug intake and drug-free period, using ultrasound biomicroscopy (UBM). MATERIALS AND METHODS: In this prospective study, UBM was done before and after pupil dilatation in 31 phakic eyes of 19 male patients taking α1-blockers. Undilated and dilated UBM was repeated before cataract extraction, after stopping the drug for 10 days...
August 2017: Turkish Journal of Ophthalmology
https://www.readbyqxmd.com/read/28793363/falls-a-fear-of-falling-and-related-factors-in-older-adults-with-complex-chronic-disease
#6
JuHee Lee, MoonKi Choi, Chang Oh Kim
AIMS AND OBJECTIVES: To identify factors influencing falls and the fear of falling among older adults with chronic diseases in Korea. BACKGROUND: The fear of falling and falls in older adults are significant health problems towards which healthcare providers should direct their attention. Further investigation is needed to improve nursing practice specifically decreasing risk of falls and the fear of falling in Korea. DESIGN: Descriptive, cross-sectional survey...
August 9, 2017: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/28761594/case-series-bladder-clot-evacuation-using-a-prostate-morcellation-device
#7
Karen M Doersch, Andrew F Navetta, Erin T Bird, Marawan M El Tayeb
INTRODUCTION: We sought to provide a technical update on the use of a prostate morcellator device (PMD) to manage organized blood clots of the bladder following laser prostatectomy. METHODS: Herein, we describe our experience in using the Wolf Piranha morcellator in managing organized bladder blood clots supplemented with a retrospective chart review of the patients in whom this procedure was performed. RESULTS: Six patients, all male with a mean age of 75 ± 8...
July 2017: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
https://www.readbyqxmd.com/read/28721283/stereological-comparison-of-intraprostatic-injection-of-alcohol-and-bleomycin-with-finasteride-gavages-in-rats
#8
Ali Eslahi, Ali Noorafshan, Ali-Reza Safarpour, Masood Sepehrimanesh, Ali Ariafara, Elham Nadimi
INTRODUCTION: Resection of the prostate is one of the standard surgical treatments for symptomatic Benign Prostatic Hyperplasia (BPH). To evaluate minimally invasive treatments, intraprostatic injections of ethanol and bleomycin were compared with oral finasteride administration in rats with BPH. MATERIAL AND METHODS: The rats were divided into six groups. The control rats received no BPH/no treatment. BPH was induced using injections of testosterone (2 mg/day/rat for 4 weeks) in groups II-VI...
June 30, 2017: Central European Journal of Urology
https://www.readbyqxmd.com/read/28694768/the-androgen-receptor-plays-different-roles-in-macrophage-induced-proliferation-in-prostate-stromal-cells-between-transitional-and-peripheral-zones-of-benign-prostatic-hypertrophy
#9
Dongliang Xu, Xingjie Wang, Chenyi Jiang, Yuan Ruan, Shujie Xia, Xiaohai Wang
Macrophages play a critical role in the process of excessive stromal proliferation of benign prostatic hyperplasia (BPH). In our previous study, we used a BPH mouse model to elucidate a potential mechanism whereby macrophage infiltration promotes stromal cell proliferation in the prostate via the androgen receptor (AR)/inflammatory cytokine CCL3-dependent pathway. In our present study, we used the co-culture system of human macrophages and various prostatic zone stromal cells to further demonstrate that infiltrating macrophages promote prostatic stromal cell proliferation through stromal AR-dependent pathways, and we show that the stroma of TZ and PZ respond to macrophages differently because of differences in stromal AR signaling; this could possibly be one of the key pathways for stromal expansion during BPH development and progression...
2017: EXCLI Journal
https://www.readbyqxmd.com/read/28694142/increased-psa-expression-on-prostate-cancer-exosomes-in-in%C3%A2-vitro-condition-and-in-cancer-patients
#10
Mariantonia Logozzi, Daniela F Angelini, Elisabetta Iessi, Davide Mizzoni, Rossella Di Raimo, Cristina Federici, Luana Lugini, Giovanna Borsellino, Alessandro Gentilucci, Federico Pierella, Vittorio Marzio, Alessandro Sciarra, Luca Battistini, Stefano Fais
Prostate specific antigen (PSA) test is the most common, clinically validated test for the diagnosis of prostate cancer (PCa). While neoplastic lesions of the prostate may cause aberrant levels of PSA in the blood, the quantitation of free or complexed PSA poorly discriminates cancer patients from those developing benign lesions, often leading to invasive and unnecessary surgical procedures. Microenvironmental acidity increases exosome release by cancer cells. In this study we evaluated whether acidity, a critical phenotype of malignancy, could influence exosome release and increase the PSA expression in nanovesicles released by PCa cells...
September 10, 2017: Cancer Letters
https://www.readbyqxmd.com/read/28646943/state-of-the-art-advanced-techniques-for-prostatic-urethral-lift-for-the-relief-of-prostate-obstruction-under-local-anesthesia
#11
Lance Patrick Walsh
Benign prostatic hypertrophy (BPH) affects an estimated 60% of men over the age of 50 and 90% of men over the age of 80. The prostatic urethral lift (PUL) is a safe and effective office-based procedure that is used worldwide for the treatment of BPH in men who are dissatisfied with medications due to side effects or lack of efficacy or don't want to have a transurethral resection of the prostate due to the side effects and invasiveness of the procedure. In 2012 Barkin et al, published the standard technique for the delivery of the Urolift implant...
June 2017: Canadian Journal of Urology
https://www.readbyqxmd.com/read/28644156/clinical-case-of-the-month-a-57-year-old-man-with-an-axillary-mass
#12
Palak Desai, Andrew Myers, Brian Boulmay, Fred A Lopez
A 57-year-old man presented to the surgical oncology clinic with a mildly tender mass under his right arm. Four years prior, the patient had a melanoma removed from his right shoulder along with an ipsilateral right axillary sentinel lymph sampling. Computed tomography (CT) scan was negative for metastatic disease at that time. The patient did not undergo completion axillary node dissection and was lost to follow-up. The patient was originally from Australia, did not tan but reported multiple sunburns before age 18...
May 2017: Journal of the Louisiana State Medical Society: Official Organ of the Louisiana State Medical Society
https://www.readbyqxmd.com/read/28637364/comparison-of-perioperative-outcomes-between-holmium-laser-enucleation-of-the-prostate-and-robot-assisted-simple-prostatectomy
#13
Mimi W Zhang, Marawan M El Tayeb, Michael S Borofsky, Casey A Dauw, Kristofer R Wagner, Patrick S Lowry, Erin T Bird, Tillman C Hudson, James E Lingeman
OBJECTIVES: To compare perioperative outcomes for patients undergoing holmium laser enucleation of the prostate (HoLEP) and robotic-assisted simple prostatectomy (RSP) for benign prostatic hypertrophy (BPH). METHODS: Patient demographics and perioperative outcomes were compared between 600 patients undergoing HoLEP and 32 patients undergoing RSP at two separate academic institutions between 2008 and 2015. RESULTS: Patients undergoing HoLEP and RSP had comparable ages (71 vs 71, p = 0...
July 19, 2017: Journal of Endourology
https://www.readbyqxmd.com/read/28631905/-rationale-of-pharmacotherapy-duration-in-patients-with-benign-prostatic-hyperplasia-a-clinical-morphological-study
#14
M E Sitdykova, D E Tsyplakov, E N Sitdykov, A R Nurtdinov
AIM: To investigate the nature of morphological alterations in the urinary bladder wall in BPH patients receiving pharmacotherapy to establish treatment time limits. MATERIALS AND METHODS: The study comprised 120 BPH patients who underwent a transvesical adenomectomy. Prior to the surgery, 110 patients received pharmacotherapy (-blockers and 5-reductase inhibitors) lasting from 1-6 months to 5-10 years. Preoperative evaluation included a standard diagnostic algorithm...
June 2017: Urologii︠a︡
https://www.readbyqxmd.com/read/28609136/can-the-urolift-prostatic-implant-device-treat-the-symptoms-of-benign-prostatic-hypertrophy-avoid-sexual-dysfunction-and-reduce-hospital-turp-waiting-times-a-single-centre-single-surgeon-experience-and-review-of-the-literature
#15
Antonio D Bardoli, Will St J Taylor, Wasim Mahmalji
BPH associated with LUTS and sexual dysfunction is common. We performed UroLift on 11 patients, average age 71 years (range 56-90). IPSS improved by an average of 9 points post-procedure. Pre-operatively their post-void residuals were 306.3 ml (range 120-499 ml SD [120.6]) and their QMAX was 7 ml/s (range 4-14 SD [2.8] ml/s). Post-procedure the post-void residual decreased by 35.4% at 4 months (mean difference - 106.3 ml). QMAX improved by an average of 1.7 ml/s, which was not statistically significant...
September 2017: Aging Male: the Official Journal of the International Society for the Study of the Aging Male
https://www.readbyqxmd.com/read/28593165/minimally-invasive-surgical-therapies-for-benign-prostatic-hypertrophy-the-rise-in-minimally-invasive-surgical-therapies
#16
REVIEW
Daniel Christidis, Shannon McGrath, Marlon Perera, Todd Manning, Damien Bolton, Nathan Lawrentschuk
The prevalence of benign prostatic hypertrophy (BPH) causing bothersome lower urinary tract symptoms increases with our ageing population. Treatment of BPH traditionally begins with medical therapy and surgical intervention is then considered for those whose symptoms progress despite treatment. Minimally invasive surgical therapies have been developed as an intermediary in the treatment of BPH with the aim of decreasing the invasiveness of interventions. These therapies also aim to reduce morbidity and dysfunction related to invasive surgical procedures...
June 2017: Prostate International
https://www.readbyqxmd.com/read/28576667/bipolar-plasma-enucleation-of-the-prostate-b-tuep-in-benign-prostate-hypertrophy-treatment-3-year-results
#17
Roberto Giulianelli, Barbara Cristina Gentile, Gabriella Mirabile, Luca Albanesi, Paola Tariciotti, Giorgio Rizzo, Maurizio Buscarini, Cristina Falavolti
OBJECTIVE: To investigate numerous endoscopic techniques that have been described for the treatment of benign prostate enlargement. Plasma-button enucleation of the prostate (B-TUEP) is a successful treatment option because the large surface creates a fast enucleation process, vaporization, and concomitant hemostasis. The aim of this study was to evaluate the efficacy of bipolar button electrode transurethral adenoma enucleation (B-TUEP) in saline solution. The second end point was to determine the change of International Prostate Symptom Score (IPSS), post-void residual urine, International Index of Erectile Function, transrectal ultrasound gland volume evaluation, and prostate-specific antigen...
May 30, 2017: Urology
https://www.readbyqxmd.com/read/28540903/recurrent-syndrome-of-inappropriate-antidiuretic-hormone-secretion-due-to-tolterodine-in-an-elderly-male-patient
#18
Abdullah K Alhwiesh, Husain Alsharani, Eman Fathi Ibrahim, Zaid Alanazi, Bushra Ahmed AlGhamdi, Nadia Alaudah, Feras Alzahrani, Adnan Alsarawi, Ashwaqu Almohaws, Ibraheem Saeed Abdurrahman
Hyponatremia is defined as serum sodium of <135 mmol/L and equates with a low serum osmolality once translocational hyponatremia and pseudohyponatremia are ruled out. True hyponatremia develops when normal urine-diluting mechanisms are disturbed. In elderly patients, this complication is not uncommon, especially in nursing homes and assisted living facilities. Medications are often the most common cause of hyponatremia in these patients. Herewith, we reported a 65-year-old Saudi male, a known case of benign prostatic hypertrophy and hypertension, who developed recurrent hyponatremia secondary to tolterodine...
May 2017: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/28537696/electron-microscopic-changes-of-detrusor-in-benign-enlargement-of-prostate-and-its-clinical-correlation
#19
Sher Singh Yadav, Rohit Bhattar, Lokesh Sharma, Gautam Banga, Trilok Chandra Sadasukhi
AIMS: To study the ultra structural changes in bladder musculature in cases of BPE and their clinical relevance. MATERIAL AND METHODS: In this descriptive longitudinal, controlled, observational study patients were enrolled into three groups, group 1, group 2A and group 2B. Control group (group-1) consisted of age matched normal male patients, who underwent surveillance or diagnostic cystoscopy for microscopic hematuria or irritative symptoms. Case group (group-2) comprised of patients with BPE, undergoing TURP...
May 23, 2017: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/28506701/case-control-study-of-intra-arterial-verapamil-for-intraprostatic-anastomoses-to-extraprostatic-arteries-in-prostatic-artery-embolization-for-benign-prostatic-hypertrophy
#20
Simon Chun Ho Yu, Carmen Cho, Esther Hung, Defeng Wang, Peter Chiu, Chi Hang Yee, Anthony Ng
PURPOSE: It is hypothesized that intra-arterial administration of verapamil is a safe and effective way to reverse the flow in intraprostatic anastomoses to extraprostatic arteries without compromising treatment outcomes in prostatic artery embolization (PAE) for benign prostatic hypertrophy (BPH). MATERIALS AND METHODS: A prospective study of 62 prostate sides in 31 consecutive patients (median age, 66 y; range, 60-71 y) with symptomatic BPH was undertaken. Median prostate volume was 72...
August 2017: Journal of Vascular and Interventional Radiology: JVIR
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