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Nivolumab hodgkin lymphoma

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https://www.readbyqxmd.com/read/30536386/novel-therapeutic-agents-for-relapsed-classical-hodgkin-lymphoma
#1
REVIEW
Gottfried von Keudell, Anas Younes
Hodgkin Lymphoma (HL) is a B-cell lymphoproliferative disorder with an excellent prognosis for the majority of patients who are treated with multi-agent chemotherapy, with or without radiation. A subset of patient, however, does not respond to therapy or relapses after accomplishing an initial response. Their outcome is poor and new treatment strategies are urgently needed for this patient population. Recent advances in the understanding of the tumour biology of HL and its microenvironment have ushered a new era of targeted- and immuno-therapies with remarkable activity...
December 11, 2018: British Journal of Haematology
https://www.readbyqxmd.com/read/30504313/where-does-pd-1-blockade-fit-in-hl-therapy
#2
REVIEW
Alex F Herrera
Genetic alterations of the PD-L1 / PD-L2 locus on chromosome 9p24.1 are a defining biological feature of classical Hodgkin lymphoma (HL). The resulting programmed death-ligand 1 (PD-L1) expression on Hodgkin Reed-Sternberg cells as well as the PD-L1 expressed in the HL microenvironment result in an ineffective host antitumor immune response and make HL a ripe target for programmed cell death-1 (PD-1) blockade. Anti-PD-1 antibody monotherapy has been effective and well tolerated in patients with relapsed or refractory (rel/ref) HL, with the majority of patients experiencing an objective response (approximately two-thirds of patients) and a median duration of response of 16...
November 30, 2018: Hematology—the Education Program of the American Society of Hematology
https://www.readbyqxmd.com/read/30410803/de-novo-psoriasis-vulgaris-diagnosed-after-nivolumab-treatment-for-refractory-hodgkin-s-lymphoma-completely-resolved-after-autologous-hematopoietic-stem-cell-transplantation
#3
Panayotis Kaloyannidis, Eshrak Al Shaibani, Miral Mashhour, Mohammed Gamil, Ioannis Apostolidis, Hani Al Hashmi, Khalid Ahmed Al Anazi
The programmed cell death protein-1 (PD-1) inhibitor nivolumab has been recently approved as an effective and safe treatment for patients with refractory/relapsed Hodgkin's lymphomas. Dermatological adverse events, mainly skin rash, have been reported in 1-5% of patients. We describe a case of de novo psoriasis vulgaris (PsV), diagnosed after nivolumab treatment for refractory Hodgkin's lymphoma. After administration of 6 cycles, skin lesions appeared in the right tibia, forearms, and dorsum of hands, and biopsy confirmed the diagnosis of PsV...
2018: Case Reports in Hematology
https://www.readbyqxmd.com/read/30407626/the-treatment-of-older-hodgkin-lymphoma-patients
#4
REVIEW
Boris Böll, Helen Görgen
The outcome of patients with Hodgkin lymphoma (HL) has dramatically improved over the past decades and continues to improve with the development of novel targeted therapies, such as the immunoconjugate brentuximab vedotin and the checkpoint inhibitors nivolumab and pembrolizumab. Moreover, with the use of response-adapted strategies using positron-emission-tomography (PET), the overall intensity of treatment for most patients can be reduced, resulting in less acute and late toxicity. However, these advances are mainly restricted to younger patients, as advances in patients above the age of 60 years ('older' patients) have been much less pronounced...
November 8, 2018: British Journal of Haematology
https://www.readbyqxmd.com/read/30339279/population-pharmacokinetics-and-exposure-safety-analyses-of-nivolumab-in-patients-with-relapsed-or-refractory-classical-hodgkin-lymphoma
#5
Xiaoli Wang, Elizabeth A Ludwig, Julie Passarell, Akintunde Bello, Amit Roy, Matthew W Hruska
Nivolumab, a fully human immunoglobulin G4 monoclonal anti-programmed death-1 antibody, has demonstrated clinical benefits in multiple tumors, including classical Hodgkin lymphoma. The aim of this study was to characterize the pharmacokinetics (PK) of nivolumab in patients with classical Hodgkin lymphoma using a population approach and to assess the exposure-response (E-R) relationship for safety, thereby supporting the dose recommendation in patients with classical Hodgkin lymphoma. Nivolumab PK and the effect of covariates were consistent with that observed in solid tumors, except that baseline clearance of nivolumab was lower in patients with classical Hodgkin lymphoma by 28%...
October 19, 2018: Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/30304963/nivolumab-for-the-treatment-of-hepatocellular-carcinoma
#6
Fabian Finkelmeier, Oliver Waidmann, Joerg Trojan
T-cell checkpoint inhibition as a cancer treatment approach has been the main breakthrough in cancer treatment during the last years. Since the approval of the first commercial CTLA-4 antibody ipilimumab in 2011 for the treatment of melanoma, research and drug development in this field has accelerated massively. In 2014, the US Food and Drug Administration (FDA) approved the first PD-1 targeting agent, namely pembrolizumab, shortly followed by nivolumab. Areas covered: Nivolumab is a fully human immunoglobulin G4 anti-PD-1 monoclonal antibody which is approved for multiple advanced malignancies, including melanoma, non-small cell lung cancer, renal cell cancer, Hodgkin's lymphoma, squamous head and neck cancer, and urothelial carcinoma...
October 10, 2018: Expert Review of Anticancer Therapy
https://www.readbyqxmd.com/read/30253728/nivolumab-induces-impressive-responses-in-relapsed-refractory-classic-hodgkin-lymphoma-single-institutional-experience
#7
Reyad Dada, Yazeed Zabani
Objectives Cancer can escape the immune system through different mechanisms. One such mechanism is the expression of program death ligand-1 which binds to PD-1 receptor on activated T cells, subsequently leading to inhibition of the immune response against cancer cells. Nivolumab is a novel antibody that binds to PD-1 and prevents such immune tolerance. Two recently published controlled clinical trials confirmed the clinical efficacy of single-agent nivolumab in pretreated patients with classical Hodgkin lymphoma...
September 26, 2018: Journal of Oncology Pharmacy Practice
https://www.readbyqxmd.com/read/30247261/immunotherapy-of-hodgkin-lymphoma-mobilizing-the-patient-s-immune-response
#8
Stephen M Ansell
Classic Hodgkin lymphoma has a unique tumor composition in that there is a paucity of malignant cells present, and most of the tumor consists of normal immune and stromal cells. Despite the presence of an immune infiltrate within the tumor microenvironment, the malignant cells effectively evade the immune system and appear to utilize the presence of immune cells to promote the growth and survival of Hodgkin-Reed-Sternberg cells. Hodgkin-Reed-Sternberg cells evade immune detection because of overexpression of programmed death 1 ligands, PD-L1 and PD-L2, which suppress T-cell activation, and loss of expression of major histocompatibility complex molecules that prevent effective immune recognition...
September 2018: Cancer Journal
https://www.readbyqxmd.com/read/30231319/new-treatment-algorithms-in-hodgkin-lymphoma-too-much-or-too-little
#9
REVIEW
Michael A Spinner, Ranjana H Advani, Joseph M Connors, Jacques Azzi, Catherine Diefenbach
Hodgkin lymphoma treatment continues to evolve as new means of assessing response to treatment, new appreciation of important risk factors, and more effective therapeutic agents become available. Treatment algorithms integrating functional imaging now provide the opportunity to modify therapy during its delivery, allowing adjustment of duration and intensity of chemotherapy and rationale identification of patients who may benefit from the addition of therapeutic irradiation. Novel agents, including the antibody drug conjugate brentuximab vedotin and checkpoint inhibitors such as nivolumab and pembrolizumab can improve the effectiveness of treatment while keeping toxicity within acceptable limits...
May 23, 2018: American Society of Clinical Oncology Educational Book
https://www.readbyqxmd.com/read/30225435/association-of-immune-mediated-cerebellitis-with-immune-checkpoint-inhibitor-therapy
#10
Joanna Zurko, Amitkumar Mehta
Immune-mediated encephalitis related to immune checkpoint inhibitor therapy is a rare but increasingly described condition that can cause significant morbidity. There are several reported cases in the literature but no previously described cases of immune-mediated cerebellitis. We describe a case of acute cerebellitis that developed in a 20-year-old man with primary refractory Hodgkin lymphoma being treated with the immune checkpoint inhibitor nivolumab. After exposure to 3 cycles of nivolumab, the patient had acute onset of headache, ataxia, nausea, and vomiting, with imaging findings of cerebellar edema, early tonsillar herniation, and early hydrocephalus...
March 2018: Mayo Clinic proceedings. Innovations, quality & outcomes
https://www.readbyqxmd.com/read/30195074/significant-risk-of-graft-versus-host-disease-with-exposure-to-checkpoint-inhibitors-before-and-after-allogeneic-transplantation
#11
Awais Ijaz, Ali Younas Khan, Saad Ullah Malik, Warda Faridi, Muhammad Asad Fraz, Muhammad Usman, Muhammad Junaid Tariq, Seren Durer, Ceren Durer, Atlantis Russ, Nadia Nunes Cavalcante Parr, Zeeshan Baig, Fnu Sagar, Zeeshan Ali, Ali McBride, Faiz Anwer
Investigators are using checkpoint inhibitors (CPIs) to treat aggressive hematologic malignancies in patients undergoing allogeneic hematopoietic stem cell transplantation (allo-HSCT) and in some patients with relapsed disease after allo-HSCT. CTLA-4 inhibitors and PD-1 inhibitors are 2 main types of CPIs, which work through activation of the immune system. On one hand, CPIs can achieve graft-versus-tumor effect, and on the other hand, there is a risk of graft-versus-host disease (GVHD). After a comprehensive literature review, we included data (n = 283) from 24 studies (11 original manuscripts and 13 case reports or case series) and evaluated the results to assess the safety and efficacy of CPI use in conjunction with allo-HSCT...
September 6, 2018: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/30149835/hodgkin-lymphoma-in-adults
#12
Paul J Bröckelmann, Dennis A Eichenauer, Tina Jakob, Markus Follmann, Andreas Engert, Nicole Skoetz
BACKGROUND: Hodgkin lymphoma is the most common neoplasm in young adults, with an incidence of 2 to 3 cases per 100 000 persons per year. Risk-adapted chemotherapy and radiotherapy usually lead to cure. Finding ways to lessen the treatment- associated morbidity and mortality is a major goal of current research. METHODS: For the creation of an updated guideline (DKH grant number 111778), a systematic literature search was carried out in medical databases (MEDLINE, CENTRAL) and guideline databases (GIN) (search dates: January 2012 to June 2017)...
August 6, 2018: Deutsches Ärzteblatt International
https://www.readbyqxmd.com/read/30149764/nivolumab-induced-cytokine-release-syndrome-in-relapsed-refractory-hodgkin-s-lymphoma-a-case-report-and-literature-review
#13
Lingdi Zhao, Yonghao Yang, Wei Li, Tiepeng Li, Quanli Gao
Hodgkin's lymphoma is a common malignant disease, especially among children in America. Although chemotherapy and radiotherapy are mainstay treatments for Hodgkin's lymphoma, a small portion of patient experiences relapsed or refractory diseases. Nivolumab provides an option for patients who experience relapsed or refractory disease, but adverse effects may occur. Here, we report a patient with relapsed/refractory Hodgkin's lymphoma who experienced cytokine-release syndrome after his first dose of nivolumab...
August 2018: Immunotherapy
https://www.readbyqxmd.com/read/30082490/strategies-for-recognizing-and-managing-immune-mediated-adverse-events-in-the-treatment-of-hodgkin-lymphoma-with-checkpoint-inhibitors
#14
Santosha Vardhana, Kara Cicero, Moises J Velez, Craig H Moskowitz
The programmed death-1 (PD-1) receptor checkpoint inhibitors nivolumab and pembrolizumab represent an important therapeutic advance in the treatment of relapsed or refractory classical Hodgkin lymphoma (cHL). Clinical trials have shown substantial therapeutic activity and an acceptable safety profile in heavily pretreated patients, resulting in U.S. Food and Drug Administration approval of nivolumab for the treatment of cHL that has relapsed or progressed after either autologous hematopoietic cell transplantation (auto-HCT) and brentuximab vedotin treatment or three or more lines of systemic therapy (including auto-HCT), and of pembrolizumab for adult or pediatric patients with refractory cHL or cHL that has relapsed after three or more prior therapies...
August 6, 2018: Oncologist
https://www.readbyqxmd.com/read/30032683/-18-f-fdg-pet-ct-for-response-assessment-in-hodgkin-lymphoma-undergoing-immunotherapy-with-checkpoint-inhibitors
#15
Angelo Castello, Fabio Grizzi, Dorina Qehajaj, Daoud Rahal, Fabio Lutman, Egesta Lopci
Our aim was to evaluate Hodgkin Lymphoma (HL) response to checkpoint inhibitors with 18 F-FDG PET/CT. Forty three refractory or relapsed HL patients were investigated before immunotherapy, 8 weeks and 17 weeks after administration of either nivolumab or pembrolizumab. The median follow-up was 19 months. Best clinical response was complete response (CR) in 26 patients, partial response (PR) in 5 patients, stable disease (SD) in 8 patients, and progression disease (PD) in 4 patients. At the early assessment, Deauville Score (DS) resulted significantly different in responder group compared to nonresponders...
July 22, 2018: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/30020193/nivolumab-treatment-for-cancers-in-the-hiv-infected-population
#16
Elaine Chang, Anita L Sabichi, Jennifer R Kramer, Christine Hartman, Kathryn E Royse, Donna L White, Niraj R Patel, Peter Richardson, Sarvari V Yellapragada, Jose M Garcia, Elizabeth Y Chiao
Nivolumab is a standard treatment option in several advanced malignancies, but safety and efficacy are still unknown in patients with human immunodeficiency virus (HIV) infection. We describe a case series of people living with HIV (PLWH) receiving nivolumab in the Veterans Health Administration (VA) and report responses and toxicities. We identified all PLWH who received nivolumab at any VA facility since 2000 in the Corporate Data Warehouse (CDW), which provides nationwide research access to VA electronic medical records...
October 2018: Journal of Immunotherapy
https://www.readbyqxmd.com/read/30002656/biomarkers-for-clinical-benefit-of-immune-checkpoint-inhibitor-treatment-a-review-from-the-melanoma-perspective-and-beyond
#17
REVIEW
Kristina Buder-Bakhaya, Jessica C Hassel
Background: Immune checkpoint inhibition (ICI) with anti-CTLA-4 and/or anti-PD-1 antibodies is standard treatment for metastatic melanoma. Anti-PD-1 (pembrolizumab, nivolumab) and anti-PD-L1 antibodies (atezolizumab, durvalumab, and avelumab) have been approved for treatment of several other advanced malignancies, including non-small-cell lung cancer (NSCLC); renal cell, and urothelial carcinoma; head and neck cancer; gastric, hepatocellular, and Merkel-cell carcinoma; and classical Hodgkin lymphoma...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/30001476/nivolumab-for-adults-with-hodgkin-s-lymphoma-a-rapid-review-using-the-software-robotreviewer
#18
REVIEW
Marius Goldkuhle, Maria Dimaki, Gerald Gartlehner, Ina Monsef, Philipp Dahm, Jan-Peter Glossmann, Andreas Engert, Bastian von Tresckow, Nicole Skoetz
BACKGROUND: Hodgkin's lymphoma (HL) is a cancer of the lymphatic system, and involves the lymph nodes, spleen and other organs such as the liver, lung, bone or bone marrow, depending on the tumour stage. With cure rates of up to 90%, HL is one of the most curable cancers worldwide. Approximately 10% of people with HL will be refractory to initial treatment or will relapse; this is more common in people with advanced stage or bulky disease. Standard of care for these people is high-dose chemotherapy and autologous stem cell transplantation (ASCT), but only 55% of participants treated with high-dose chemotherapy and ASCT are free from treatment failure at three years, with an overall survival (OS) of about 80% at three years...
July 12, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29986908/novel-agents-for-primary-central-nervous-system-lymphoma-evidence-and-perspectives
#19
REVIEW
Gerald Illerhaus, Elisabeth Schorb, Benjamin Kasenda
Primary central nervous system lymphoma (PCNSL) is a rare aggressive extranodal non- Hodgkin lymphoma. Although high remission rates can be achieved with high-dose methotrexate-based immunochemotherapy, risk of relapse and associated death is still substantial in at least a third of patients. Novel agents for treating lymphoid malignancies have substantially enriched treatment options for PCNSL. We herein systematically review the existing clinical evidence of novel agents in treatment of PCNSL, summarize ongoing studies, and discuss perspectives...
August 16, 2018: Blood
https://www.readbyqxmd.com/read/29949442/complete-local-and-abscopal-responses-from-a-combination-of-radiation-and-nivolumab-in-refractory-hodgkin-s-lymphoma
#20
Qian Qin, Xinyu Nan, Tara Miller, Ronald Fisher, Bin Teh, Shruti Pandita, Andrew M Farach, Sai Ravi Pingali, Raj K Pandita, E Brian Butler, Tej K Pandita, Swaminathan P Iyer
Until recently, patients with relapsed Hodgkin's lymphoma after brentuximab vedotin (Bv) treatments had poor treatment outcomes. Checkpoint inhibitors such as nivolumab and pembrolizumab that bind to and inhibit programmed cell death protein-1 (PD-1), have demonstrated an overall response rate of 70% in Hodgkin's lymphoma patients; however, complete response is still low at 20% with median progression-free survival of 14 months. There are ongoing clinical studies to seek out synergistic combinations, with the goal of improving the complete response rates for the cure of Hodgkin's lymphoma...
September 2018: Radiation Research
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