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Dust mite AND genome

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https://www.readbyqxmd.com/read/30090644/diesel-exhaust-and-house-dust-mite-allergen-lead-to-common-changes-in-the-airway-methylome-and-hydroxymethylome
#1
Xue Zhang, Xiaoting Chen, Matthew T Weirauch, Xiang Zhang, J D Burleson, Eric B Brandt, Hong Ji
Exposures to diesel exhaust particles (DEP) from traffic and house dust mite (HDM) allergens significantly increase risks of airway diseases, including asthma. This negative impact of DEP and HDM may in part be mediated by epigenetic mechanisms. Beyond functioning as a mechanical barrier, airway epithelial cells provide the first line of immune defense towards DEP and HDM exposures. To understand the epigenetic responses of airway epithelial cells to these exposures, we exposed human bronchial epithelial cells to DEP and HDM and studied genome-wide 5-methyl-cytosine (5mC) and 5-hydroxy-methylcytosine (5hmC) at base resolution...
July 2018: Environmental Epigenetics
https://www.readbyqxmd.com/read/29692198/nasal-dna-methylation-is-associated-with-childhood-asthma
#2
Xue Zhang, Jocelyn M Biagini Myers, J D Burleson, Ashley Ulm, Kelly S Bryan, Xiaoting Chen, Matthew T Weirauch, Theresa A Baker, Melinda S Butsch Kovacic, Hong Ji
AIM: We aim to study DNA methylation (DNAm) variations associated with childhood asthma. METHODS: Nasal DNAm was compared between sibling pairs discordant for asthma, 29 sib pairs for genome-wide association studies and 54 sib pairs for verification by pyrosequencing. Associations of methylation with asthma symptoms, allergy and environmental exposures were evaluated. In vitro experiments and functional genomic analyses were performed to explore biologic relevance...
May 2018: Epigenomics
https://www.readbyqxmd.com/read/29535264/tslp-signaling-in-cd4-t-cells-programs-a-pathogenic-t-helper-2-cell-state
#3
Yrina Rochman, Krista Dienger-Stambaugh, Phoebe K Richgels, Ian P Lewkowich, Andrey V Kartashov, Artem Barski, Gurjit K Khurana Hershey, Warren J Leonard, Harinder Singh
Pathogenic T helper 2 (TH 2) cells, which produce increased amounts of the cytokines interleukin-5 (IL-5) and IL-13, promote allergic disorders, including asthma. Thymic stromal lymphopoietin (TSLP), a cytokine secreted by epithelial and innate immune cells, stimulates such pathogenic TH 2 cell responses. We found that TSLP signaling in mouse CD4+ T cells initiated transcriptional changes associated with TH 2 cell programming. IL-4 signaling amplified and stabilized the genomic response of T cells to TSLP, which increased the frequency of T cells producing IL-4, IL-5, and IL-13...
March 13, 2018: Science Signaling
https://www.readbyqxmd.com/read/29377900/rewired-rnai-mediated-genome-surveillance-in-house-dust-mites
#4
Mosharrof Mondal, Pavel Klimov, Alex Sutton Flynt
House dust mites are common pests with an unusual evolutionary history, being descendants of a parasitic ancestor. Transition to parasitism is frequently accompanied by genome rearrangements, possibly to accommodate the genetic change needed to access new ecology. Transposable element (TE) activity is a source of genomic instability that can trigger large-scale genomic alterations. Eukaryotes have multiple transposon control mechanisms, one of which is RNA interference (RNAi). Investigation of the dust mite genome failed to identify a major RNAi pathway: the Piwi-associated RNA (piRNA) pathway, which has been replaced by a novel small-interfering RNA (siRNA)-like pathway...
January 2018: PLoS Genetics
https://www.readbyqxmd.com/read/29250067/group-2-innate-lymphoid-cells-exhibit-a-dynamic-phenotype-in-allergic-airway-inflammation
#5
Bobby W S Li, Ralph Stadhouders, Marjolein J W de Bruijn, Melanie Lukkes, Dior M J M Beerens, Maarten D Brem, Alex KleinJan, Ingrid Bergen, Heleen Vroman, Mirjam Kool, Wilfred F J van IJcken, Tata Nageswara Rao, Hans Jörg Fehling, Rudi W Hendriks
Group 2 innate lymphoid cells (ILC2) are implicated in allergic asthma as an early innate source of the type 2 cytokines IL-5 and IL-13. However, their induction in house dust mite (HDM)-mediated airway inflammation additionally requires T cell activation. It is currently unknown whether phenotypic differences exist between ILC2s that are activated in a T cell-dependent or T cell-independent fashion. Here, we compared ILC2s in IL-33- and HDM-driven airway inflammation. Using flow cytometry, we found that surface expression levels of various markers frequently used to identify ILC2s were dependent on their mode of activation, highly variable over time, and differed between tissue compartments, including bronchoalveolar lavage (BAL) fluid, lung, draining lymph nodes, and spleen...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29111218/the-notch-pathway-inhibitor-stapled-%C3%AE-helical-peptide-derived-from-mastermind-like-1-sahm1-abrogates-the-hallmarks-of-allergic-asthma
#6
Alex KleinJan, Irma Tindemans, Jeffrey E Montgomery, Melanie Lukkes, Marjolein J W de Bruijn, Menno van Nimwegen, Ingrid Bergen, Raymond E Moellering, Henk C Hoogsteden, Louis Boon, Derk Amsen, R W Hendriks
BACKGROUND: The Notch signaling pathway has been implicated in the pathogenesis of allergic airway inflammation. Targeting the active Notch transactivation complex by using the cell-permeable, hydrocarbon-stapled synthetic peptide stapled α-helical peptide derived from mastermind-like 1 (SAHM1) resulted in genome-wide suppression of Notch-activated genes in leukemic cells and other models. However, the efficacy of SAHM1 in allergic asthma models has remained unexplored. OBJECTIVE: We aimed to investigate the therapeutic efficacy of SAHM1 in a house dust mite (HDM)-driven asthma model...
July 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29045689/sensitivity-to-house-dust-mites-allergens-with-atopic-asthma-and-its-relationship-with-cd14-c-159t-polymorphism-in-patients-of-west-bengal-india
#7
Amlan Ghosh, Shampa Dutta, Sanjoy Podder, Priti Mondal, Arghya Laha, Nimai Chandra Saha, Saibal Moitra, Goutam Kumar Saha
India is the home to around 15-20 million asthmatics, and asthma prevalence is increasing in Indian metropolitan area, including Kolkata, West Bengal. Complex interactions of genetic and environmental factors are involved in asthma. Genome-wide search for susceptible loci regulating IgE response (atopy) have identified a candidate gene CD14 which is most important in the context of allergic responses of respiratory system. This study was aimed to investigate the role of house dust and house dust mites in development of bronchial asthma and to explore the possible association of candidate gene CD14 with disease manifestation among Kolkata patient population...
January 10, 2018: Journal of Medical Entomology
https://www.readbyqxmd.com/read/28977706/dust-mite-induces-multiple-polar-t-cell-axes-in-human-skin
#8
K Malik, B Ungar, S Garcet, R Dutt, D Dickstein, X Zheng, H Xu, Y D Estrada, M Suárez-Fariñas, A Shemer, J G Krueger, E Guttman-Yassky
BACKGROUND: House dust mite/HDM atopy patch test/APT elicits positive reactions in a high fraction of atopic dermatitis/AD and healthy individuals. Experimental systems for new-onset/chronic AD are needed to support rapid therapeutic development, particularly since animal models representing human AD are lacking. While HDM APT has been considered to simulate AD, its suitability to model AD's emerging Th2/Th22 phenotype with Th1 and Th17 components is unknown. OBJECTIVE: To assess whether HDM APT reproduces AD...
December 2017: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28904857/-dermatophagoides-pteronyssinus-lytfm-encoding-an-nlpc-p60-endopeptidase-is-also-present-in-mite-associated-bacteria-that-express-lytfm-variants
#9
Vivian H Tang, Geoffrey A Stewart, Barbara J Chang
The bodies and faecal pellets of the house dust mite (HDM), Dermatophagoides pteronyssinus , are the source of many allergenic and nonallergenic proteins. One of these, the 14-kDa bacteriolytic enzyme LytFM, originally isolated from the spent HDM growth medium, may contribute to bacteriolytic activity previously detected by zymography at 14 kDa in the culture supernatants of some bacterial species isolated from surface-sterilised HDM. Based on previously reported findings of lateral gene transfer between microbes and their eukaryotic hosts, we investigated the presence of lytFM in the genomes of nine Gram-positive bacteria from surface-sterilised HDM, and the expression by these isolates of LytFM and its variants LytFM1/LytFM2...
September 2017: FEBS Open Bio
https://www.readbyqxmd.com/read/28829832/allergen-homologs-in-the-euroglyphus-maynei-draft-genome
#10
S Dean Rider, Marjorie S Morgan, Larry G Arlian
Euroglyphus maynei is a house dust mite commonly found in homes worldwide and is the source of allergens that sensitize and induce allergic reactions in humans. It is the source of species-specific allergens as well as allergens that are cross-reactive with the allergens from house dust mites Dermatophagoides farinae and D. pteronyssinus, and the ectoparasitic scabies mite Sarcoptes scabiei. The genomics, proteomics and molecular biology of E. maynei and its allergens have not been as extensively investigated as those of D...
2017: PloS One
https://www.readbyqxmd.com/read/28798186/draft-genome-sequence-of-dermatophagoides-pteronyssinus-the-european-house-dust-mite
#11
Rose Waldron, Jamie McGowan, Natasha Gordon, Charley McCarthy, E Bruce Mitchell, Sean Doyle, David A Fitzpatrick
Dermatophagoides pteronyssinus is the European dust mite and a major source of human allergens. Here, we present the first draft genome sequence of the mite, as well as the ab initio gene prediction and functional analyses that will facilitate comparative genomic analyses with other mite species.
August 10, 2017: Genome Announcements
https://www.readbyqxmd.com/read/28759611/tpl-2-restricts-ccl24-dependent-immunity-to-heligmosomoides-polygyrus
#12
Yashaswini Kannan, Lewis J Entwistle, Victoria S Pelly, Jimena Perez-Lloret, Alan W Walker, Steven C Ley, Mark S Wilson
TPL-2 (COT, MAP3K8) kinase activates the MEK1/2-ERK1/2 MAPK signaling pathway in innate immune responses following TLR, TNFR1 and IL-1R stimulation. TPL-2 contributes to type-1/Th17-mediated autoimmunity and control of intracellular pathogens. We recently demonstrated TPL-2 reduces severe airway allergy to house dust mite by negatively regulating type-2 responses. In the present study, we found that TPL-2 deficiency resulted in resistance to Heligmosomoides polygyrus infection, with accelerated worm expulsion, reduced fecal egg burden and reduced worm fitness...
July 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28741705/house-dust-mites-as-potential-carriers-for-ige-sensitization-to-bacterial-antigens
#13
S Dzoro, I Mittermann, Y Resch-Marat, S Vrtala, M Nehr, A M Hirschl, G Wikberg, L Lundeberg, C Johansson, A Scheynius, R Valenta
BACKGROUND: IgE reactivity to antigens from Gram-positive and Gram-negative bacteria is common in patients suffering from respiratory and skin manifestations of allergy, but the routes and mechanisms of sensitization are not fully understood. The analysis of the genome, transcriptome and microbiome of house dust mites (HDM) has shown that Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli) species are abundant bacteria within the HDM microbiome. Therefore, our aim was to investigate whether HDM are carriers of bacterial antigens leading to IgE sensitization in patients suffering from atopic dermatitis...
January 2018: Allergy
https://www.readbyqxmd.com/read/28692122/alteration-of-656-g-t-and-607-c-a-polymorphisms-in-interleukin-18-il-18-gene-in-house-dust-mite-sensitive-allergic-rhinitis-patients-in-thailand
#14
A Tungtrongchitr, J Jumpasri, N Sookrung, N Visitsunthorn, P Tantilipikorn, O Piboonpocanan, N Indrawattana, R Tungtrongchitr, W Chaicumpa
Allergic rhinitis (AR) is an IgE-mediated inflammation of the nasal membranes, which is naturally triggered by aeroallergens. House dust mites (HDM) are the most common inhalant allergens. Interleukin-18 (IL-18) has been established as an essential cytokine that can activate the generation of IgE. This randomized controlled study aimed to identify the possible relationship of the genetic variations in the IL-18 gene with AR in mite-sensitive Thai patients. Study subjects consisted of 150 AR patients and 50 normal participants...
July 6, 2017: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/28587273/proteases-of-dermatophagoides-pteronyssinus
#15
Thomas A Randall, Robert E London, Michael C Fitzgerald, Geoffrey A Mueller
Since the discovery that Der p 1 is a cysteine protease, the role of proteolytic activity in allergic sensitization has been explored. There are many allergens with proteolytic activity; however, exposure from dust mites is not limited to allergens. In this paper, genomic, transcriptomic and proteomic data on Dermatophagoides pteronyssinus (DP) was mined for information regarding the complete degradome of this house dust mite. D. pteronyssinus has more proteases than the closely related Acari, Dermatophagoides farinae (DF) and Sarcoptes scabiei (SS)...
June 6, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28543436/prenatal-environmental-tobacco-smoke-exposure-increases-allergic-asthma-risk-with-methylation-changes-in-mice
#16
Sonja Christensen, Zeina Jaffar, Elizabeth Cole, Virginia Porter, Maria Ferrini, Britten Postma, Kent E Pinkerton, Mihi Yang, Yang Jee Kim, Luke Montrose, Kevan Roberts, Andrij Holian, Yoon Hee Cho
Allergic asthma remains an inadequately understood disease. In utero exposure to environmental tobacco smoke (ETS) has been identified as an environmental exposure that can increase an individual's asthma risk. To improve our understanding of asthma onset and development, we examined the effect of in utero ETS exposure on allergic disease susceptibility in an asthmatic phenotype using a house dust mite (HDM) allergen-induced murine model. Pregnant C57BL/6 mice were exposed to either filtered air or ETS during gestation, and their offspring were further exposed to HDM at 6-7 weeks old to induce allergic inflammation...
July 2017: Environmental and Molecular Mutagenesis
https://www.readbyqxmd.com/read/28167095/genome-wide-interaction-study-of-dust-mite-allergen-on-lung-function-in-children-with-asthma
#17
Erick Forno, Joanne Sordillo, John Brehm, Wei Chen, Takis Benos, Qi Yan, Lydiana Avila, Manuel Soto-Quirós, Michelle M Cloutier, Angel Colón-Semidey, Maria Alvarez, Edna Acosta-Pérez, Scott T Weiss, Augusto A Litonjua, Glorisa Canino, Juan C Celedón
BACKGROUND: Childhood asthma is likely the result of gene-by-environment (G × E) interactions. Dust mite is a known risk factor for asthma morbidity. Yet, there have been no genome-wide G × E studies of dust mite allergen on asthma-related phenotypes. OBJECTIVE: We sought to identify genetic variants whose effects on lung function in children with asthma are modified by the level of dust mite allergen exposure. METHODS: A genome-wide interaction analysis of dust mite allergen level and lung function was performed in a cohort of Puerto Rican children with asthma (Puerto Rico Genetics of Asthma and Lifestyle [PRGOAL])...
October 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28091681/microbial-rrna-sequencing-analysis-of-evaporative-cooler-indoor-environments-located-in-the-great-basin-desert-region-of-the-united-states
#18
Angela R Lemons, Mary Beth Hogan, Ruth A Gault, Kathleen Holland, Edward Sobek, Kimberly A Olsen-Wilson, Yeonmi Park, Ju-Hyeong Park, Ja Kook Gu, Michael L Kashon, Brett J Green
Recent studies conducted in the Great Basin Desert region of the United States have shown that skin test reactivity to fungal and dust mite allergens are increased in children with asthma or allergy living in homes with evaporative coolers (EC). The objective of this study was to determine if the increased humidity previously reported in EC homes leads to varying microbial populations compared to homes with air conditioners (AC). Children with physician-diagnosed allergic rhinitis living in EC or AC environments were recruited into the study...
February 22, 2017: Environmental Science. Processes & Impacts
https://www.readbyqxmd.com/read/28030368/sphingolipids-ormdl3-and-asthma-what-is-the-evidence
#19
REVIEW
Tilla S Worgall
PURPOSE OF REVIEW: Genome-wide association studies identified ORMDL3, a protein of the endoplasmic reticulum, as a significant asthma risk factor. ORMDL3 is one of three ORMDL proteins that integrate multiple signals to maintain sphingolipid homeostasis. Studies that investigated potential mechanisms for how increased ORMDL3 might affect asthma are summarized. RECENT FINDINGS: Investigations focused on decreased sphingolipid synthesis and on the unfolded protein response because ORMDL3 had been implicated in both...
March 2017: Current Opinion in Clinical Nutrition and Metabolic Care
https://www.readbyqxmd.com/read/27838380/neuropeptide-evolution-chelicerate-neurohormone-and-neuropeptide-genes-may-reflect-one-or-more-whole-genome-duplications
#20
Jan A Veenstra
Four genomes and two transcriptomes from six Chelicerate species were analyzed for the presence of neuropeptide and neurohormone precursors and their GPCRs. The genome from the spider Stegodyphus mimosarum yielded 87 neuropeptide precursors and 101 neuropeptide GPCRs. High neuropeptide transcripts were also found in the trancriptomes of three other spiders, Latrodectus hesperus, Parasteatoda tepidariorum and Acanthoscurria geniculata. For the scorpion Mesobuthus martensii the numbers are 79 and 74 respectively...
November 9, 2016: General and Comparative Endocrinology
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