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Severe Oligozoospermia

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https://www.readbyqxmd.com/read/30499012/incidence-of-y-chromosome-microdeletions-in-patients-with-klinefelter-syndrome
#1
F Sciarra, M Pelloni, F Faja, F Pallotti, G Martino, A F Radicioni, A Lenzi, F Lombardo, D Paoli
PURPOSE: The aim of this study was to study the incidence of Y chromosome microdeletions in a Caucasian population of Klinefelter syndrome (KS) patients and to investigate the possible association between Y chromosome microdeletions and KS. MATERIALS AND METHODS: We conducted a retrospective study on 118 KS patients, 429 patients with non-obstructive azoospermia (NOA), and 155 normozoospermic men. Eight of the 118 KS patients had undergone testicular sperm extraction (TESE)...
November 29, 2018: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/30449700/do-men-with-normal-testosterone-oestradiol-ratios-benefit-from-letrozole-for-the-treatment-of-male-infertility
#2
Liu Shuling, Matthew Lau Sie Kuei, Seyed Ehsan Saffari, Zheng Jiayun, Tan Tse Yeun, Jessie Phoon Wai Leng, Veronique Viardot-Foucault, Sadhana Nadarajah, Jerry Kok Yen Chan, Tan Heng Hao
RESEARCH QUESTION: Previous studies of aromatase inhibitors on male infertility have focused on men with low testosterone-oestradiol ratio of less than 10. Can aromatase inhibitors improve spermatogenesis in men with idiopathic male infertility with normal testosterone-oestradiol ratio? DESIGN: Prospective study of men with idiopathic severe oligozoospermia (sperm concentration <5 million/ml) carried out between February 2015 and March 2017. The objective was to assess if semen-analysis parameters improved after treatment with letrozole...
October 30, 2018: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/30373665/idiopathic-male-infertility-is-strongly-associated-with-aberrant-dna-methylation-of-imprinted-loci-in-sperm-a-case-control-study
#3
Qiuqin Tang, Feng Pan, Jing Yang, Ziqiang Fu, Yiwen Lu, Xian Wu, Xiumei Han, Minjian Chen, Chuncheng Lu, Yankai Xia, Xinru Wang, Wei Wu
BACKGROUND: Male infertility is a complex disease caused by a combination of genetic, environmental, and lifestyle factors. Abnormal epigenetic programming has been proposed as a possible mechanism compromising male fertility. Recent studies suggest that aberrant imprinting in spermatozoa in a subset of infertile men is a risk factor for congenital diseases in children conceived via assisted reproduction techniques. In this study, we examined the DNA methylation status of CpG sites within the differentially methylated regions (DMRs) of three imprinted genes, H19, GNAS, and DIRAS3, using combined bisulfite PCR restriction analysis and bisulfite sequencing in sperm obtained from 135 men with idiopathic male infertility, including normozoospermia (n = 39), moderate oligozoospermia (n = 45), and severe oligozoospermia (n = 51), and fertile controls (n = 59)...
October 29, 2018: Clinical Epigenetics
https://www.readbyqxmd.com/read/30288482/the-frequency-of-tp53-r72p-and-mdm2-309t-g-polymorphisms-in-iranian-infertile-men-with-spermatogenetic-failure-a-case-control-study
#4
Zeinab Ebrahim Abadi, Maryam Khademi Bami, Maryam Golzadeh, Seyed Mehdi Kalantar, Mohammad Hasan Sheikhha
Background: Tumor protein p53 ( TP53 ) is a tumor suppressor transcriptional regulator protein which plays a critical role in the spermatogenesis. One of the most important regulators of p53 is Murine double minute 2 ( MDM2 ), which acts as a negative regulator of the p53 pathway. Based on the key role of p53 and MDM2 in germ cell apoptosis, polymorphisms that cause a change in their function might affect germ cell apoptosis and the risk of male infertility. Objective: This study was designed to examine associations of TP53 72 Arg>Pro (rs1042522), and MDM2 309 T>G (rs937283) polymorphisms with spermatogenetic failure in Iranian population...
August 2018: International Journal of Reproductive Biomedicine (Yazd, Iran)
https://www.readbyqxmd.com/read/30276841/schistosomiasis-bilharziasis-and-male-infertility
#5
Mohamed Badawy Abdel-Naser, Andreas Altenburg, Christos C Zouboulis, Uwe Wollina
Schistosomiasis (bilharziasis) is an endemic parasitic disease of a major source of morbidity and mortality for developing countries. It is caused by different species of blood flukes (trematode worms) of the genus Schistosoma, the most important of which are S. haematobium which infests the genitourinary tract and S. mansoni and S. japonicum which infest the gastrointestinal tract. The incidence of schistosome-induced male infertility is not known and probably underestimated being overshadowed by the more severe and often fatal urinary and gastrointestinal complications...
October 1, 2018: Andrologia
https://www.readbyqxmd.com/read/30243299/spermatogenesis-improved-by-suppressing-the-high-level-of-endogenous-gonadotropins-in-idiopathic-non-obstructive-azoospermia-a-case-control-pilot-study
#6
Xuechun Hu, Zheng Ding, Zhiwei Hong, Zhichuan Zou, Yuming Feng, Ruilou Zhu, Jinzhao Ma, Xie Ge, Chaojun Li, Bing Yao
BACKGROUND: Elevated plasma gonadotropins were associated with desensitization of Sertoli and Leydig cells in the male testis. Testis spermatogenesis ability would be improved via inhibiting high endogenous gonadotropin in patients with severe oligozoospermia. Whether it would be beneficial for non-obstructive azoospermia (NOA) patients was still unclear. METHODS: Goserelin, a gonadotropin releasing hormone agonist (GnRHα) was used to suppress endogenous gonadotropin levels (gonadotropin reset) in the NOA patients, improving the sensitization of the Sertoli and Leydig cells...
September 22, 2018: Reproductive Biology and Endocrinology: RB&E
https://www.readbyqxmd.com/read/30173455/-correlation-of-the-single-nucleotide-polymorphisms-rs34349826-and-rs6521-of-the-lhb-gene-with-male-infertility-in-chinese-men
#7
Mao-Mao Yu, Li-Li Guo, Pei-Ran Zhu, Qiu-Yue Wu, Jing Zhang, Hong-Bo Sun, Yu-Ling Yin, Hui-Jie Zhi, Li Zhou, Xin-Yi Xia
Objective: To study the relationship of the single nucleotide polymorphisms (SNP) rs34349826 (c.104 A>G) and rs6521 (c.114 C>G) of the luteinizing hormone beta-subunit (LHB) gene with male infertility in Chinese men. METHODS: This case-control study included 405 males with primary infertility (the infertility group) and 424 normal fertile men (the control group), the former again divided into subgroups of oligospermia, severe oligozoospermia and azoospermia according to the sperm concentration...
June 2018: Zhonghua Nan Ke Xue, National Journal of Andrology
https://www.readbyqxmd.com/read/30173429/-advantages-of-cryopreservation-technology-for-rare-human-sperm
#8
Ding-Ming Li, Bo Liu, Yang Xian, Li-Juan Ying, Yan Zheng, Min Jiang, Fu-Ping Li, Huan-Xun Yue
Objective: To search for an effective method for cryopreservation of rare human sperm (RHS) by comparing the effect of RHS cryopreservation technology with that of conventional cryopreservation technology on post-thaw sperm from patients with severe oligozoospermia. METHODS: Semen samples obtained from 82 patients with severe oligozoospermia were preserved by RHS cryopreservation technology, and another 24 samples cryopreserved by conventional technology, the former divided into groups A (sperm concentration < 1×10⁶/ml, n = 54) and B (1×10⁶/ml ≤ sperm concentration < 5×10⁶/ml, n = 28), and the latter included in group C (sperm concentration < 15×106 /ml, n = 24)...
August 2018: Zhonghua Nan Ke Xue, National Journal of Andrology
https://www.readbyqxmd.com/read/30053768/identification-of-two-novel-mutations-in-kdm3a-regulatory-gene-in-iranian-infertile-males
#9
Zohreh Hojati, Elaheh Soleimanpour, Seyed-Morteza Javadirad, Mohammad Hossein Nasr-Esfahani
Background: KDM3A is a key epigenetic regulator that is expressed in the testis and is required for packaging and condensation of sperm chromatin. To this point, the association of the KDM3A gene and infertility has not been studied in human. The aim of this study was to screen any new mutation in KDM3A gene to explore more details of human male infertility. Methods: In this work, 150 infertile men (oligozoospermia and azoospermia) and 150 normal healthy fathers were studied...
July 28, 2018: Iranian Biomedical Journal
https://www.readbyqxmd.com/read/29973189/testicular-histopathology-semen-analysis-and-fsh-predictive-value-of-sperm-retrieval-supportive-counseling-in-case-of-reoperation-after-testicular-sperm-extraction-tese
#10
REVIEW
Lucio Gnessi, Filomena Scarselli, Maria Giulia Minasi, Stefania Mariani, Carla Lubrano, Sabrina Basciani, Pier Francesco Greco, Mikiko Watanabe, Giorgio Franco, Alessio Farcomeni, Ermanno Greco
BACKGROUND: To provide indicators for the likelihood of sperm retrieval in patients undergoing testicular sperm extraction is a major issue in the management of male infertility by TESE. The aim of our study was to determine the impact of different parameters, including testicular histopathology, on sperm retrieval in case of reoperation in patients undergoing testicular sperm extraction. METHODS: We retrospectively analyzed 486 patients who underwent sperm extraction for intracytoplasmic sperm injection and testicular biopsy...
July 4, 2018: BMC Urology
https://www.readbyqxmd.com/read/29942932/nfkb1-rs28362491-and-pre-mirna-146a-rs2910164-snps-on-e-cadherin-expression-in-case-of-idiopathic-oligospermia-a-case-control-study
#11
Matem Tunçdemir, Güven Yenmiş, Kübra Tombultürk, Hülya Arkan, Tuğba Soydaş, Rasit Burak Tek, Özlem Altıntaş, Hamdi Özkara, Gönül Kanıgür-Sultuybek
Background: A notable proportion of idiopathic male infertility cases is accompanied by oligozoospermia; and yet, the molecular mechanisms of fertilization problem underlying this defect are still unclear. Epithelial cadherin has been involved in several calcium-dependent cell-to-cell adhesion events; however, its participation in gamete interaction has also not been fully investigated. Objective: The aim was to investigate the changes in the expression of E-cadherin, based on the frequency of Single nucleotide polymorphisms in Nuclear Factor Kappa-B 1 and pre-mir-146a in oligospermic men...
April 2018: International Journal of Reproductive Biomedicine (Yazd, Iran)
https://www.readbyqxmd.com/read/29798938/sperm-origins-and-concentration-do-not-impact-the-clinical-outcomes-in-intracytoplasmic-sperm-injection-cycles
#12
Cen Yang, Ze-Hong Zhou, Dan-Ni Zheng, Xiao-Fei Xu, Jin Huang, Ying Lian, Jie Qiao
In the present study, we evaluated the impact of sperm origins and concentration on the clinical outcomes of intracytoplasmic sperm injection (ICSI) cycles. A total of 1201 ICSI cycles were retrospectively analyzed for male azoospermia or oligozoospermia between January 2015 and December 2015 in the Peking University Third Hospital. Patients were divided into three groups (Group 1 vs Group 2/3; surgically extracted sperm vs ejaculated sperms): Group 1 included 343 ICSI cycles and Group 2 analyzed 388 cycles on semen with sperm concentration <5 × 106 ml-1 (severe oligozoospermia group)...
September 2018: Asian Journal of Andrology
https://www.readbyqxmd.com/read/29713544/chromosomal-abnormalities-in-infertile-men-with-azoospermia-and-severe-oligozoospermia-in-qatar-and-their-association-with-sperm-retrieval-intracytoplasmic-sperm-injection-outcomes
#13
Mohamed M Arafa, Ahmad Majzoub, Sami S AlSaid, Walid El Ansari, Abdulla Al Ansari, Yara Elbardisi, Haitham T Elbardisi
Objective: To study the types and incidence of chromosomal abnormalities in infertile men with azoospermia and severe oligozoospermia in Qatar, and to compare the hormonal changes, testicular sperm retrieval rate, and intracytoplasmic sperm injection (ICSI) outcome between patients with chromosomal abnormalities and patients with idiopathic infertility. Patients and methods: This study involved the retrospective chart review of 625 infertile male patients attending an academic tertiary medical centre in Qatar...
March 2018: Arab Journal of Urology
https://www.readbyqxmd.com/read/29707937/detection-of-y-chromosome-microdeletions-and-hormonal-profile-analysis-of-infertile-men-undergoing-assisted-reproductive-technologies
#14
Ardeshir Bahmanimehr, Shahryar Zeighami, Bahia Namavar Jahromi, Zahra Anvar, Mohammad Ebrahim Parsanezhad, Maryam Davari, Somayeh Montazeri
Background: Y chromosome deletions (YCDs) in azoospermia factor (AZF) region are associated with abnormal spermatogenesis and may lead to azoospermia or severe oligozoospermia. Assisted reproductive technologies (ART) by intracytoplasmic sperm injection (ICSI) and testicular sperm extraction (TESE) are commonly required for infertility management of patients carrying YCDs. The aim of this study was to estimate the frequency of YCDs, to find the most frequent variant in infertile men candidate for ART and to compare YCD distribution with a control fertile group...
July 2018: International Journal of Fertility & Sterility
https://www.readbyqxmd.com/read/29684482/two-cases-of-complex-balanced-autosomal-translocations-associated-with-severe-oligozoospermia
#15
Yan-Wei Sha, Li-Bin Mei, Zhi-Yong Ji, Lu Ding, Yunsheng Ge, Qiong Wu, Hui Kong, Zhi-Ying Su, Ping Li
Complex balanced autosomal translocation is rare and can lead to impaired spermatogenesis in males; however, its effects on oligozoospermia have rarely been reported. We report here two cases of rare complex balanced translocation in men with infertility. The karyotype of the first case was 46,XY,der(1)t(1;12)(p22;p11.2)ins(9;1)(p24;q25q23),der(9)ins(9;1),der(12)t(1;12)·ish der(1)t(1;12)(RP11-636B1+;RP11-659D23+)ins(9;1)(RP11-118P13+),der(9)ins(9;1),der(12)t(1;12). And the patient showed severe oligozoospermia with adult schizophrenia without other abnormalities...
July 15, 2018: Gene
https://www.readbyqxmd.com/read/29540081/testing-for-genetic-contributions-to-infertility-potential-clinical-impact
#16
Csilla Krausz, Francesca Cioppi, Antoni Riera-Escamilla
Male infertility affects about 7% of the general male population, and it is a multifactorial, polygenic pathological condition. Known genetic factors, accounting for about 20-25% of male factor infertility, are present in each etiological category: i) hypothalamic-pituitary axis dysfunction; ii) quantitative and qualitative alterations of spermatogenesis; iii) ductal obstruction/dysfunction. Areas covered: All routinely available genetic tests are described. Indication for testing for chromosomal anomalies and Y chromosome microdeletions is based on sperm count (severe oligozoospermia/azoospermia)...
April 2018: Expert Review of Molecular Diagnostics
https://www.readbyqxmd.com/read/29538680/spontaneous-fertility-in-a-male-patient-with-testotoxicosis-despite-suppression-of-fsh-levels
#17
M Cunha-Silva, V N Brito, D B Macedo, D S Bessa, C O Ramos, L G Lima, P S Barroso, I J P Arnhold, D L Segaloff, B B Mendonca, A C Latronico
Testotoxicosis is a rare cause of peripheral precocious puberty in boys caused by constitutively activating mutations of the LHCG receptor. Affected males usually have normal gonadotropin profiles and fertility in their adult life. Here, we described the long-term follow-up of a 24-year-old young man with severe testotoxicosis due to a de novo activating mutation in the third transmembrane helix of the LHCGR (p.Leu457Arg). This patient was treated with different medications, including medroxyprogesterone acetate, ketoconazole, cyproterone acetate and aromatase inhibitor from age 2...
May 1, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29282757/level-of-neutral-alpha-1-4-glucosidase-in-seminal-plasma-of-chinese-men
#18
Z Qiu, Q Chu, W Zhang, C Luo, S Quan
Neutral alpha-1,4-glucosidase (NAG) is a crucial biomarker for the function of epididymis and is reported to be associated with semen quality. However, the correlation between NAG and Chinese semen quality has never been reported. This study aimed to investigate the level of NAG in the seminal plasma of Chinese men. A total of 394 cases of seminal plasma samples from normal, subfertile and infertile men were enrolled in this study. Male subfertility was caused by teratozoospermia, asthenospermia, severe oligozoospermia, asthenoteratozoospermia, oligoasthenospermia and oligoasthenoteratozoospermia...
April 2018: Andrologia
https://www.readbyqxmd.com/read/29082206/the-society-for-translational-medicine-clinical-practice-guidelines-for-sperm-dna-fragmentation-testing-in-male-infertility
#19
REVIEW
Ashok Agarwal, Chak-Lam Cho, Ahmad Majzoub, Sandro C Esteves
Sperm DNA fragmentation (SDF) testing has been emerging as a valuable tool for male fertility evaluation. While the essential role of sperm DNA integrity in human reproduction was extensively studied, the clinical indication of SDF testing is less clear. This clinical practice guideline provides recommendations of clinical utility of the test supported by evidence. It is intended to serve as a reference for fertility specialists in identifying the circumstances in which SDF testing should be of greatest clinical value...
September 2017: Translational Andrology and Urology
https://www.readbyqxmd.com/read/29063501/the-normality-of-sperm-in-an-infertile-man-with-ring-chromosome-15-a-case-report
#20
Kazuyo Nishikawa, Fumiaki Itoi, Miki Nagahara, Mami Jose, Ayumi Matsunaga, Jun Ueda, Takashi Iwamoto
PURPOSE: The purpose of this report is to analyze the chromosome status and fertilization capability of sperm obtained from an infertile male patient with ring chromosome 15. METHODS: This was a case report at a private in vitro fertilization clinic. A man diagnosed with severe oligozoospermia carrying ring chromosome 15. To evaluate the chromosome status and fertilization capability, sperm from a patient carrying ring chromosome 15 were injected into enucleated mouse oocytes...
February 2018: Journal of Assisted Reproduction and Genetics
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