Feng Li, Ling-Ling Qian, Li-Da Wu, Zhen-Ye Zhang, Lei Zhang, Huan-Huan Liu, Ning Zhao, Jie Zhang, Jia-Yi Chen, Fan Yang, Zhi-Yuan Zhang, Chao Wang, Shi-Peng Dang, Xiao-Xi Zhao, Ku-Lin Li, Wen-Qing Zhu, Yan Yao, Ru-Xing Wang
BACKGROUND: Recent evidence revealed that glucose fluctuation might be more likely to cause arrhythmia than persistent hyperglycemia, whereas its mechanisms were elusive. We aimed to investigate the effect of glucose fluctuation on the occurrence of ventricular arrhythmia and its mechanism. METHODS: Streptozotocin (STZ) induced diabetic rats were randomized to five groups: the controlled blood glucose (C-STZ) group, uncontrolled blood glucose (U-STZ) group, fluctuated blood glucose (GF-STZ) group, and GF-STZ rats with 100 mg/kg Tempol (GF-STZ + Tempol) group or with 5 mg/kg KN93 (GF-STZ + KN93) group...
November 6, 2023: European Journal of Pharmacology