keyword
https://read.qxmd.com/read/38644706/antioxidative-and-anti-inflammatory-effects-of-plant-derived-hypoglycemic-medicines-an-in-vivo-in-vitro-systematic-review
#21
JOURNAL ARTICLE
Mohammad Sadegh Adel-Mehraban, Ozra Tabatabaei-Malazy, Azadeh Manayi, Sudabeh Alatab, Shahrzad Mohseni, Saeed Ebrahimi Fana, Pooria Asili, Roodabeh Bahramsoltani, Fataneh Esmaeili, Bayan Azizi
BACKGROUND: The activation of oxidative stress and inflammatory conditions has been associated with acceleration in diabetes (DM) onset and complications. Despite various anti-DM medications, there is a growing trend to discover inexpensive and effective treatments with low adverse effects from plants as one of the promising sources for drug development. OBJECTIVE: This study aimed to systematically investigate the simultaneous anti-inflammatory and antioxidant effects of plant-derived hypoglycemic medicines in diabetic experimental models...
April 19, 2024: Current Topics in Medicinal Chemistry
https://read.qxmd.com/read/38644039/gastrointestinal-anthelmintic-plants-used-on-small-ruminants-in-benin-traditional-use-and-scientific-results-review
#22
REVIEW
Kétomon Pierre Challaton, Coovi Guénolé Akouedegni, Goué Géorcelin Alowanou, Kadoéito Cyrille Boko, Placide Mahougnan Toklo, Mawulé Sylvie Hounzangbé-Adoté
In Benin, livestock breeders frequently use medicinal plants to treat gastrointestinal diseases in small ruminants. The aim of this review is to list the plants traditionally used in this context and to present the scientific findings on the efficacy of these plants. An extensive search was carried out using PubMed, Scopus, ScienceDirect, Biomed Central and Google Scholar databases to collect data, with combinations of relevant french and english keywords such as "ethnobotanical survey", "anthelmintic properties", "medicinal plants", "gastrointestinal parasites", "digestive strongyles", "Haemonchus", "Trichostrongylus", "small ruminants", "sheep", "goats" and "Benin"...
May 2024: Veterinary Parasitology (Amsterdam)
https://read.qxmd.com/read/38643436/mycorrhizal-symbiosis-in-taxus-a-review
#23
REVIEW
Neha Sharma, Ashwani Tapwal
Taxus, a genus of conifers known for its medicinal significance, faces various conservation challenges with several species classified under different threat categories by the IUCN. The overharvesting of bark and leaves for the well-known chemotherapy drug paclitaxel has resulted in its population decline. Exploring the mycorrhizal relationship in Taxus is of utmost importance, as mycorrhizal fungi play pivotal roles in nutrition, growth, and ecological resilience. Taxus predominantly associates with arbuscular mycorrhizal fungi (AM), and reports suggest ectomycorrhizal (EM) or dual mycorrhizal associations as well...
April 21, 2024: Mycorrhiza
https://read.qxmd.com/read/38642916/phytochemical-profile-and-hepatoprotective-potentiality-of-phyllanthus-genus-a-review
#24
JOURNAL ARTICLE
H Pratima, Anita Shiraguppi, Priyadarshini Joojagar, Kamal Shah, Sudharani S Cheeraladinni, P Shivakumar Singh, Suresh Kumar Mendem, Nagendra Singh Chauhan
The Phyllanthus genus is very important plant traded as a raw herbal medicine in India. Commonly known as 'Bhumyamalaki' (Phyllanthus species) has been used for the prevention and treatment of jaundice. Phyllanthus is rich in diversity of bioactive compounds such as lignans, alkaloids, terpenoids, flavonoids, and tannins. Among some metabolites such as phyllanthin, hypophyllanthin, 8, 9-epoxy brevifolin, brevifolin, quercetin, gallic acid, elagic acid, and brevifolin carboxylate have been shown to have hepatoprotective and antioxidant activity found in this genus...
April 20, 2024: Journal of Pharmacy and Pharmacology
https://read.qxmd.com/read/38642413/targeting-cd8-t-cells-with-natural-products-for-tumor-therapy-revealing-insights-into-the-mechanisms
#25
REVIEW
Yuke Wang, Yan Zeng, Wenyong Yang, Xiuxuan Wang, Jingwen Jiang
BACKGROUND: Despite significant advances in cancer immunotherapy over the past decades, such as T cell-engaging chimeric antigen receptor (CAR)-T cell therapy and immune checkpoint blockade (ICB), therapeutic failure resulting from various factors remains prevalent. Therefore, developing combinational immunotherapeutic strategies is of great significance for improving the clinical outcome of cancer immunotherapy. Natural products are substances that naturally exist in various living organisms with multiple pharmacological or biological activities, and some of them have been found to have anti-tumor potential...
April 8, 2024: Phytomedicine
https://read.qxmd.com/read/38641075/bioeconomy-and-ethnopharmacology-translational-perspective-and-sustainability-of-the-bioresources-of-northeast-region-of-india
#26
REVIEW
Bhaskar Das, Pardeep K Bhardwaj, Sushil K Chaudhary, Neeta Pathaw, Huidrom Khelemba Singh, Soibam Tampha, Khaidem Kennedy Singh, Nanaocha Sharma, Pulok Kumar Mukherjee
ETHNOPHARMACOLOGICAL RELEVANCE: The ecological environment of Northeast region of India (NER), with its high humidity, has resulted in greater speciation and genetic diversity of plant, animal, and microbial species. This region is not only rich in ethnic and cultural diversity, but it is also a major biodiversity hotspot. The sustainable use of these bioresources can contribute to the region's bioeconomic development. AIM OF THE STUDY: The review aimed to deliver various perspectives on the development of bioeconomy from NER bioresources under the tenets of sustainable utilization and socioeconomic expansion...
April 17, 2024: Journal of Ethnopharmacology
https://read.qxmd.com/read/38640337/role-and-molecular-mechanism-of-salvia-miltiorrhiza-associated-with-chemical-compounds-in-the-treatment-of-diabetes-mellitus-and-its-complications-a-review
#27
JOURNAL ARTICLE
Jiajie Li, Jinxing Liu, Weibing Shi, Jinchen Guo
Diabetes mellitus (DM) is one of the most prevalent diseases worldwide, greatly impacting patients' quality of life. This article reviews the progress in Salvia miltiorrhiza, an ancient Chinese plant, for the treatment of DM and its associated complications. Extensive studies have been conducted on the chemical composition and pharmacological effects of S miltiorrhiza, including its anti-inflammatory and antioxidant activities. It has demonstrated potential in preventing and treating diabetes and its consequences by improving peripheral nerve function and increasing retinal thickness in diabetic individuals...
April 19, 2024: Medicine (Baltimore)
https://read.qxmd.com/read/38639277/aloe-emodin-progress-in-pharmacological-activity-safety-and-pharmaceutical-formulation-applications
#28
JOURNAL ARTICLE
Haimeng Luoa, Xiaoyun Jia, Mengyu Zhanga, Yaoyao Renb, Rui Tana, Hezhong Jianga, Xiaoqing Wua
Aloe-emodin (AE) is an anthraquinone derivative and a biologically active component sourced from various plants, including Rheum palmatum L. and Aloe vera. Known chemically as 1,8-dihydroxy-3-hydroxymethyl-anthraquinone, AE has a rich history in traditional medicine and is esteemed for its accessibility, safety, affordability, and effectiveness. AE boasts multiple biochemical and pharmacological properties, such as strong antibacterial, antioxidant, and antitumor effects. Despite its array of benefits, AE's identity as an anthraquinone derivative raises concerns about its potential for liver and kidney toxicity...
April 18, 2024: Mini Reviews in Medicinal Chemistry
https://read.qxmd.com/read/38639276/nutritional-value-therapeutic-effects-phytochemistry-and-toxicology-of-lepisanthes-fruticosa-a-review
#29
JOURNAL ARTICLE
Lim Joe Siang, Harish Rajak, Veerasamy Ravichandran
The multifaceted benefits of Lepisanthes fruticosa position it is not only as a promising agricultural commodity but also as a versatile resource with implications for health, biodiversity, and economic growth. Lepisanthes fruticosa has a rich history of traditional use for treating various ailments such as fever and diarrhea. Beyond its traditional uses, the plant's antioxidant properties suggest potential applications in combating oxidative stress-related conditions. Its antihyperglycemic properties indicate promise in managing elevated blood sugar levels, while its antibacterial and antiviral attributes hint at potential applications in infectious disease control...
April 18, 2024: Current Topics in Medicinal Chemistry
https://read.qxmd.com/read/38639052/20-potentially-new-compounds-and-11-new-bioactive-constituents-found-in-smilacis-glabrae-rhizoma-utilizing-hplc-dad-esi-it-tof-ms-n
#30
JOURNAL ARTICLE
Gegentana, Feng Xu, Yan-Fei Huang, Hong-Fu Li, Ping Yang, Ming-Ying Shang, Guang-Xue Liu, Yao-Li Li, Xuan Wang, Shao-Qing Cai
INTRODUCTION: Smilacis Glabrae Rhizoma (SGR) is rich in chemical constituents with a variety of pharmacological activities. However, in-depth research has yet to be conducted on the chemical and pharmacodynamic constituents of SGR. MATERIALS AND METHODS: In this study, the chemical constituents of SGR were analyzed using liquid chromatography-mass spectrometry, and the pharmacodynamic compounds responsible for the medicinal effects of SGR were elucidated through a literature review...
April 19, 2024: Phytochemical Analysis: PCA
https://read.qxmd.com/read/38638945/the-genus-polygonum-an-updated-comprehensive-review-of-its-ethnomedicinal-phytochemical-pharmacological-activities-toxicology-and-phytopharmaceutical-formulation
#31
REVIEW
Sourour Idoudi, Audrey Tourrette, Jalloul Bouajila, Mehrez Romdhane, Walid Elfalleh
Polygonum is a plant genus that includes annual and perennial species and is found at various temperatures, from northern temperate regions to tropical and subtropical areas. The genus Polygonum has been used for centuries for various disorders, including hypertension, intestinal and stomach pain, dysuria, jaundice, toothaches, skin allergies, hemorrhoids, cardiac disorders, kidney stones, hemostasis, hyperglycemia, and others. Various databases, including Google Scholar, Scifinder, ScienceDirect, PubMed, Scopus, ResearchGate, and Web of Science, were utilized to collect pertinent scientific literature data...
April 30, 2024: Heliyon
https://read.qxmd.com/read/38638051/harnessing-the-therapeutic-potential-of-dillenia-indica-an-overview-of-recent-dosage-form-developments
#32
JOURNAL ARTICLE
Aditya Bora, Pallab Kalita, Parimita Kalita, Rudra Pasad Adhikari, Aaditya Das, Rizuwan Zaheer, Mustaf Alam Laskar, Kalyani Pathak
Dillenia indica, commonly known as Elephant Apple, is a significant medicinal plant found in Assam, North-East India. This evergreen shrub or small to medium-sized tree possesses not only tasty components but also a plethora of beneficial therapeutic characteristics. This review article aims to explore the potential use of Dillenia indica in the treatment of diabetes and other diseases, as well as discuss various patents associated with this plant. The study focuses on identifying different formulations derived from various parts of Dillenia indica...
April 17, 2024: Current Drug Discovery Technologies
https://read.qxmd.com/read/38636575/chinese-herbal-medicine-for-the-treatment-of-diabetic-nephropathy-from-clinical-evidence-to-potential-mechanisms
#33
REVIEW
Xiao-Xiao Gong, Lin-Hai Cao, Hong-Xia Ni, Zi-Yan Zang, Hui Chang
ETHNOPHARMACOLOGICAL RELEVANCE: Diabetic nephropathy (DN) is a typical chronic microvascular complication of diabetes, characterized by proteinuria and a gradual decline in renal function. At present, there are limited clinical interventions aimed at preventing the progression of DN to end-stage renal disease (ESRD). However, Chinese herbal medicine presents a distinct therapeutic approach that can be effectively combined with conventional Western medicine treatments to safeguard renal function...
April 16, 2024: Journal of Ethnopharmacology
https://read.qxmd.com/read/38636573/future-aspects-of-plant-derived-bioactive-metabolites-as-therapeutics-to-combat-benign-prostatic-hyperplasia
#34
REVIEW
Raman Krishnamoorthi, Anand Ganapathy A, Hari Priya V M, Alaganandam Kumaran
ETHNOPHARMACOLOGICAL RELEVANCE: Benign prostatic hyperplasia (BPH), characterized by prostate enlargement due to cell proliferation, is a common urinary disorder in men over 50, manifesting as lower urinary tract symptoms (LUTS). Currently, several therapeutic options are accessible for treating BPH, including medication therapy, surgery and watchful waiting. Conventional drugs such as finasteride and dutasteride are used as 5α-reductase inhibitors for the treatment of BPH. However long-term use of these drugs is restricted due to their unpleasant side effects...
April 16, 2024: Journal of Ethnopharmacology
https://read.qxmd.com/read/38634408/a-mechanistic-review-on-growing-multiple-therapeutic-applications-of-lutein-and-its-global-market-research
#35
REVIEW
Ashish Sunil Akkewar, Km Abha Mishra, Mahesh Gopichand Kamble, Sanjay Kumar, Juhi Dey, Kalyan Kumar Sethi
Lutein is a naturally occurring carotenoid synthesized by plants and algae that has a beneficial effect on several biological processes and associated ailments. Its immediate application is in ophthalmology, where it significantly lowers the incidences of age-related macular degeneration (AMD). It also has anti-inflammatory action, treatment of diabetic retinopathy, and cataracts, and enhancement of visual contrast. To critically assess lutein biosynthesis, therapeutic applicability, and market research literature...
April 18, 2024: Phytotherapy Research: PTR
https://read.qxmd.com/read/38633888/endophytic-aspergillii-and-penicillii-from-medicinal-plants-a-focus-on-antimicrobial-and-multidrug-resistant-pathogens-inhibitory-activity
#36
REVIEW
Jendri Mamangkey, Lucas William Mendes, Apon Zaenal Mustopa, Adrian Hartanto
The rise of multidrug resistance among microorganisms, where they develop resistance against formerly efficacious drugs, has led to increased disease prevalence and mortality rates, posing a growing challenge. Globally, antibiotic resistance has made a significant impact, causing millions of fatalities each year. Endophytic fungi have gained considerable attention in research due to their potential to produce a wide variety of secondary metabolites, including natural substances with antimicrobial capabilities...
2024: Biotechnologia
https://read.qxmd.com/read/38633612/the-traditional-uses-pharmacology-and-phytochemistry-of-peucedanum-praeruptorum-dunn
#37
REVIEW
Qiongxiao Wang, Qingmei Sun, Qinger Huang, Luping Qin, Bo Zhu
Bai Hua Qian Hu (Qianhu; Peucedanum praeruptorum Dunn) is a classical medicinal plant traditionally prescribed for respiratory ailments, including cough, pulmonary hypertension, and asthma. In this review, we summarize the research progress of the toxicology, pharmacokinetics, pharmacology, phytochemistry, botany, quality control, and traditional uses of P. praeruptorum in order to support future investigations into the scientific and therapeutic promise of this important medicinal plant. Information pertaining to P...
2024: Frontiers in Pharmacology
https://read.qxmd.com/read/38628679/strategies-for-reducing-noxious-gas-emissions-in-pig-production-a-comprehensive-review-on-the-role-of-feed-additives
#38
REVIEW
Md Mortuza Hossain, Sung Bo Cho, In Ho Kim
The emission of noxious gases is a significant problem in pig production, as it can lead to poor production, welfare concerns, and environmental pollution. The noxious gases are the gasses emitted from the pig manure that contribute to air pollution. The increased concentration of various harmful gasses can pose health risks to both animals and humans. The major gases produced in the pig farm include methane, hydrogen sulfide, carbon dioxide, ammonia, sulfur dioxide and volatile fatty acids, which are mainly derived from the fermentation of undigested or poorly digested nutrients...
March 2024: Journal of Animal Science and Technology
https://read.qxmd.com/read/38628649/targeting-bone-homeostasis-regulation-potential-of-traditional-chinese-medicine-flavonoids-in-the-treatment-of-osteoporosis
#39
REVIEW
Jiazhe Du, Yincang Wang, Chengliang Wu, Xinyu Zhang, Xiaofeng Zhang, Xilin Xu
Osteoporosis is a systemic metabolic disease characterized by disrupted bone formation/resorption and homeostasis. Flavonoids extracted from traditional Chinese medicinal plants regulate bone homeostasis by intervening in differentiating bone marrow mesenchymal stem cells, balancing the bone immune system, inhibiting oxidative stress response, and reversing iron overload. The target molecules and signaling pathways, such as Wnt/β-catenin and OPG/RANKL/RANK, directly affect osteoblast/osteoclast activity, exhibiting significant potential in the treatment of OP...
2024: Frontiers in Pharmacology
https://read.qxmd.com/read/38627963/plant-derived-nanovesicles-offer-a-promising-avenue-for-anti-aging-interventions
#40
REVIEW
Yiming Meng, Jing Sun, Tao Yu, Haozhe Piao
Over the past few years, the study of plant-derived nanovesicles (PDNVs) has emerged as a hot topic of discussion and research in the scientific community. This remarkable interest stems from their potential role in facilitating intercellular communication and their unique ability to deliver biologically active components, including proteins, lipids, and miRNAs, to recipient cells. This fascinating ability to act as a molecular courier has opened up an entirely new dimension in our understanding of plant biology...
2024: Physiologia Plantarum
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