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JOURNAL ARTICLE
Sai-Feng Huang, Yue Teng, Hui-Qing Shi, Wen-Juan Chen, Xue-Hua Zhang
OBJECTIVE: Diagnosing musculoskeletal infections in children is challenging. In recent years, with the advancement of ultrasound technology, high-resolution ultrasound has unique advantages for musculoskeletal children. The aim of this work is to summarize the ultrasonographic and clinical characteristics of children with pyogenic arthritis and osteomyelitis. This study provides a simpler and more effective diagnostic basis for clinical treatment. METHODS: Fifty children with osteomyelitis or arthritis were diagnosed via ultrasound, and the results of the ultrasound diagnosis were compared with those of magnetic resonance imaging and surgery...
April 4, 2024: Journal of Orthopaedic Surgery and Research
#2
Mahmood Alam, Robert J Okapa, Rola Husain
Tuberculosis of the hip is a relatively rare type of septic arthritis that is seldom seen in the developed world today. While pyogenic septic arthritis may present with clear features that help in early diagnosis and treatment, many of these features are absent or overlap significantly with tuberculous arthritis, making the diagnosis a clinical challenge. Here, we present a case of tuberculous septic arthritis seen in our clinic following the surgical incision and drainage of a groin abscess with minimal hip symptoms...
February 2024: Curēus
#3
JOURNAL ARTICLE
Usman Nakakana, Alimamy Serry-Bangura, Bassey Effiom Edem, Pietro Tessitore, Leonardo Di Cesare, Danilo Gomes Moriel, Audino Podda, Iris Sarah De Ryck, Ashwani Kumar Arora
Superficial infections with Streptococcus pyogenes (Strep A), pharyngitis and impetigo can induce acute rheumatic fever, an autoimmune sequela manifesting mostly with arthritis and rheumatic carditis. Valvular heart damage can persist or advance following repeated episodes of acute rheumatic fever, causing rheumatic heart disease. Acute rheumatic fever and rheumatic heart disease disproportionately affect children and young adults in developing countries and disadvantaged communities in developed countries...
March 18, 2024: Drugs in R&D
#4
JOURNAL ARTICLE
Yuto Otsubo, Meiwa Shibata, Hiroshi Hataya, Norikazu Ota, Yuho Horikoshi
BACKGROUND: Acute bacterial arthritis (ABA) is a serious, pediatric infection that can result in motor comorbidities. Normally, a joint fluid white blood cell (WBC) count of 50,000 or more cells/mm3 is used to make a presumptive diagnosis of ABA. This study evaluated the utility of the joint fluid WBC count for diagnosing pediatric ABA confirmed by a positive culture result. METHODS: Patients with ABA between March 2010 and March 2023 at Tokyo Metropolitan Children's Medical Center were included...
March 4, 2024: Pediatric Infectious Disease Journal
#5
REVIEW
Carlo Alberto Maronese, Chiara Moltrasio, Angelo Valerio Marzano
Hidradenitis suppurativa (HS) is an autoinflammatory skin disorder of the terminal hair follicle, which can present in sporadic, familial, or syndromic form. A classification has been proposed for the latter, distinguishing cases associated with a known genetic condition, with follicular keratinization disorders or with autoinflammatory diseases. This review focuses on the clinical and genetic features of those entities (ie, pyoderma gangrenosum [PG], acne and HS; PG, acne, pyogenic arthritis and HS; psoriatic arthritis, PG, acne and HS; synovitis, acne, pustulosis, hyperostosis, osteitis; and so forth) for which the collective term HS-related autoinflammatory syndromes is proposed...
April 2024: Dermatologic Clinics
#6
JOURNAL ARTICLE
Wonyong Lee, Deborah L Stone, Patrycja Hoffmann, Sofia Rosenzweig, Wanxia Li Tsai, Massimo Gadina, Tina Romeo, Chyi-Chia Richard Lee, Davide Randazzo, Pallavi Pimpale Chavan, Kalpana Manthiram, Scott Canna, Yong Hwan Park, Amanda K Ombrello, Ivona Aksentijevich, Daniel L Kastner, Jae Jin Chae
OBJECTIVES: To study the molecular pathogenesis of PAPA (pyogenic arthritis, pyoderma gangrenosum and acne) syndrome, a debilitating hereditary autoinflammatory disease caused by dominant mutation in PSTPIP1 . METHODS: Gene knock-out and knock-in mice were generated to develop an animal model. THP1 and retrovirally transduced U937 human myeloid leukaemia cell lines, peripheral blood mononuclear cells, small interfering RNA (siRNA) knock-down, site-directed mutagenesis, cytokine immunoassays, coimmunoprecipitation and immunoblotting were used to study inflammasome activation...
February 26, 2024: Annals of the Rheumatic Diseases
#7
Bin Shen, Luyuan Tong, Jia Qiu, Jianfeng Zhong, Zhaowei Tong, Xiaofeng Li
BACKGROUND: Streptococcus suis ( S. suis ) is a common gram-positive bacterium in pigs. Its natural infection sites are the upper respiratory tract (especially tonsils and nasal cavity), reproductive tract and digestive tract of pigs. It is a new emerging human and animal disease. A co-morbid pathogen that can cause serious infections in humans, including meningitis, sepsis, septic arthritis, and sometimes deafness. No cases have been reported in Huzhou City, Zhejiang Province, China...
2024: Infection and Drug Resistance
#8
Kyoichi Sanada, Jun Tanaka, Takuaki Yamamoto
INTRODUCTION: There are few reports of cases with vertical subluxation. We report our experience of a vertical subluxation of the atlantoaxial joint caused by infection. CASE REPORT: A 63-year-old man had a 5-month history of neck pain. He was treated for rheumatoid arthritis by a local doctor. At admission to our hospital, he had neck pain and complained of dysphagia and hoarseness. His white blood cell count and C-reactive protein were 7200/mm3 and 4.86 mg/dL...
January 2024: Journal of Orthopaedic Case Reports
#9
JOURNAL ARTICLE
Merve Iseri Nepesov, Omer Kilic, Enes Sali, Edanur Yesil, Asuman Akar, Ayse Kaman, Ozge Metin Akcan, Merve Kilic Cil, Canan Ozlu, Sibel Lacinel Gurlevik, Emel Ulusoy, Benhur Sirvan Cetin, Narin Akici, Deniz Cakir, Fatma Deniz Uslu Aygun, Cafer Ozgur Hancerli, Ayse Tekin Yilmaz, Gulsum Alkan, Hatice Uygun, Ibrahim Hakan Bucak, Burcu Bursal, Taylan Celik, Murat Sutcu, Fatma Nur Oz, Zeynep Gokce Gayretli Aydin, Adem Karbuz, Hacer Akturk, Eda Kepenekli, Melike Emiroglu, Selim Oncel, Cagatay Nuhoglu, Ismail Hakki Korucu, Mustafa Incesu, Ahmet Kaya, Hasan Bombaci, Meltem Dinleyici, Kursat Bora Carman, Murat Duman, Ozden Turel, Dilek Yilmaz, Derya Alabaz, Nursen Belet, Gonul Tanir, Mehmet Turgut, Solmaz Celebi, Necdet Kuyucu, Emin Sami Arisoy, Gul Durmaz, Mucahit Kaya, Ates Kara, Ener Cagri Dinleyici
OBJECTIVES: Septic arthritis (SA) is a serious bacterial infection that must be treated efficiently and timely. The large number of culture-negative cases makes local epidemiological data important. Accordingly, this study aimed to evaluate the etiology, clinical characteristics, and therapeutic approach of SA in children in Turkiye, emphasizing the role of real-time polymerase chain reaction (PCR) techniques in the diagnosis. METHODS: In this multi-center, prospective study, children hospitalized due to SA between February 2018 and July 2020 in 23 hospitals in 14 cities in Turkiye were included...
January 22, 2024: Children
#10
REVIEW
Wiem Abid, Mohamed F Ladeb, Natesan Chidambaranathan, Wilfred C G Peh, Filip M Vanhoenacker
Tuberculosis (TB) represents a major public health problem worldwide. Any tissue may be infected. Involvement of the musculoskeletal (MSK) system account for 1-3% of all tuberculous infections. MSK TB may manifest as tuberculous spondylitis, arthritis, osteomyelitis, and soft tissue infections. Although TB spondylitis may present with distinctive imaging features compared to pyogenic infections of the spine, the imaging semiology of extra-spinal TB infections is mostly nonspecific and may mimic other lesions...
January 17, 2024: Skeletal Radiology
#11
Daichi Umemoto, Shigeo Hara, Hiroaki Nishioka
Corynebacterium striatum occasionally causes nosocomial infections, such as catheter-related bloodstream infection and pneumonia; however, C. striatum-related infective endocarditis or septic arthritis is uncommon. We present the case of an 85-year-old woman with infective endocarditis at the native valve and septic arthritis at the native shoulder joint caused by C. striatum. The patient was admitted for a 10-day history of fever and right shoulder pain. She had no history of artificial device implantation, injury, arthrocentesis, or hospitalization...
December 22, 2023: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
#12
REVIEW
Flore Wouters, Jeroen Bogie, Andy Wullaert, Jeroen van der Hilst
Pyrin is a cytosolic protein encoded by the MEFV gene, predominantly expressed in innate immune cells. Upon activation, it forms an inflammasome, a multimolecular complex that enables the activation and secretion of IL-1β and IL-18. In addition, the Pyrin inflammasome activates Gasdermin D leading to pyroptosis, a highly pro-inflammatory cell death. Four autoinflammatory syndromes are associated with Pyrin inflammasome dysregulation: familial Mediterranean fever, hyper IgD syndrome/mevalonate kinase deficiency, pyrin-associated autoinflammation with neutrophilic dermatosis, and pyogenic arthritis, pyoderma gangrenosum, and acne syndrome...
December 22, 2023: Journal of Clinical Immunology
#13
Leyla Ozbek, Jonathon Kyriakides, Ajay Asokan
Septic arthritis is a serious condition resulting in rapid destruction of articular cartilage and potential sepsis. Bacterial invasion of a joint occurs most commonly as a result of haematogenous spread from a distant infection. However, an otogenic source of this transient bacteraemia and resultant septic arthritis has not yet been reported in the literature. We report a case of acute septic arthritis of the knee with Streptococcus pyogenes , secondary to acute otitis media of the ear.
December 2023: Journal of Surgical Case Reports
#14
Jae-Hyuk Yang, Jae Hoon Kim, Sang Won Lee, Hyun Soo Soh, Hwa Pyung Kim, Sang-Gyun Kim
Undifferentiated arthritis is a disease that clinically presents with symptoms and signs of inflammatory arthritis but does not meet the specific diagnostic criteria of rheumatoid arthritis (RA) or spondyloarthropathy. Here, we report our experience with a patient whose diagnosis of RA was delayed due to a lack of evidence for RA. The patient complained of knee joint swelling and pain, but the clinical features did not match those of typical pyogenic arthritis. Because infection could not be completely ruled out, the patient was treated for pyogenic arthritis using arthroscopic synovectomy and antibiotics...
December 2023: Heliyon
#15
REVIEW
Takashi K Satoh
Pyoderma gangrenosum (PG), hidradenitis suppurativa (HS), and the associated autoinflammatory syndromes, including pyogenic arthritis, pyoderma gangrenosum, and acne (PAPA) syndrome, PSTPIP1-associated myeloid-related proteinemia inflammatory (PAMI) syndrome, pyoderma gangrenosum, acne, and hidradenitis suppurativa (PASH) syndrome, and pyogenic arthritis, pyoderma gangrenosum, acne, and suppurative hidradenitis (PAPASH) syndrome are dermatological conditions characterized by chronic inflammation and tissue damage...
November 30, 2023: Journal of Dermatology
#16
JOURNAL ARTICLE
Hana Smajlović, Asja Prohić
For over two decades, the acronym PAPA syndrome has been used to describe an autoinflammatory condition caused by missense mutations in the PSTPIP1 (proline-serine-threonine phosphatase interacting protein 1) gene and clinically characterized by the presence of pyogenic arthritis, pyoderma gangrenosum (PG), and acne (1,2). Due to the involvement of the PSTPIP1 gene in the regulation of innate immunity, mutations of this gene cause abnormal activation of inflammasomes, complexes of NLRP3/ASC/caspase-1 proteins...
November 2023: Acta Dermatovenerologica Croatica: ADC
#17
JOURNAL ARTICLE
Lin Cheng, Wei-Li Du, Ying Zhang, Zhong Chen, Yu-Ming Shen
The anatomic position of the patella is superficial, making it vulnerable to injuries. Treatment of patella infection after internal fixation surgery remains a big challenge due to minimal soft tissue coverage and vital tissue exposure. Forty-two patients aged 10 to 59 years were admitted to the institution's burn unit between January 2010 and December 2019. Each presented with infection after patellar fracture surgery. Twenty-seven infections were superficial, whereas 15 were deep with pyogenous arthritis of the knee...
November 20, 2023: Journal of Craniofacial Surgery
#18
Nantaporn Pirogard, Emvalee Arromdee, Sorranart Muangsomboon, Pinyo Rattanaumpawan
We report the world's sixth case of rat bite fever caused by Streptobacillus notomytis that mimicked pyogenic polyarthritis and required surgical debridement in combination with prolonged antibiotic therapy. This case report highlights the higher severity of rat bite fever caused by S. notomytis compared to S. moniliformis.
2023: IDCases
#19
JOURNAL ARTICLE
Thanit Foocharoen, Tippawan Onchan, Patnarin Pongkulkiat, Ajanee Mahakkanukrauh, Siraphop Suwannaroj, Chingching Foocharoen
BACKGROUND: A better understanding of the epidemiological profile of septic arthritis or pyogenic arthritis in Thais could improve care and provide information for better infectious control. We aimed to determine the incidence and prevalence of septic arthritis in Thailand between 2017 and 2020. METHODS: A descriptive epidemiological study was performed using demographic data from patients over 18 years of age having a primary diagnosis of M00 pyogenic arthritis between 2017 and 2020...
2023: Open Access Rheumatology: Research and Reviews
#20
JOURNAL ARTICLE
Ana Gabriela Fuentes-Nava, Leonel Fierro-Arias, Juan Carlos Zenteno, David Apam-Garduño
No abstract text is available yet for this article.
November 6, 2023: Clinical and Experimental Dermatology
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