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https://www.readbyqxmd.com/read/30078041/whole-body-magnetic-resonance-imaging-techniques-and-non-oncologic-indications
#1
REVIEW
Mary-Louise C Greer
Whole-body MRI is increasingly utilized for assessing oncologic and non-oncologic diseases in infants, children and adolescents. Focusing on the non-oncologic indications, this review covers technical elements required to perform whole-body MRI, the advantages and limitations of the technique, and protocol modifications tailored to specific indications. Rheumatologic diseases account for the majority of non-oncologic whole-body MRI performed in pediatric patients at the author's institution. Whole-body MRI helps in establishing the diagnosis, documenting disease extent and severity, and monitoring treatment response in enthesitis-related arthritis (ERA) and chronic recurrent multifocal osteomyelitis (CRMO)...
August 2018: Pediatric Radiology
https://www.readbyqxmd.com/read/30061892/streptococcal-endo-%C3%AE-n-acetylglucosaminidase-suppresses-antibody-mediated-inflammation-in-vivo
#2
Kutty Selva Nandakumar, Mattias Collin, Kaisa E Happonen, Susanna L Lundström, Allyson M Croxford, Bingze Xu, Roman A Zubarev, Merrill J Rowley, Anna M Blom, Christian Kjellman, Rikard Holmdahl
Endo-β- N -acetylglucosaminidase (EndoS) is a family 18 glycosyl hydrolase secreted by Streptococcus pyogenes . Recombinant EndoS hydrolyzes the β-1,4-di- N -acetylchitobiose core of the N-linked complex type glycan on the asparagine 297 of the γ-chains of IgG. Here, we report that EndoS and IgG hydrolyzed by EndoS induced suppression of local immune complex (IC)-mediated arthritis. A small amount (1 µg given i.v. to a mouse) of EndoS was sufficient to inhibit IgG-mediated arthritis in mice. The presence of EndoS disturbed larger IC lattice formation both in vitro and in vivo , as visualized with anti-C3b staining...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29967892/neutropenia-and-t-wave-inversion-as-toxin-mediated-complications-of-a-streptococcal-infection
#3
Cristina Popescu, Anca Leuştean, Alina Elena Orfanu, Codruţa Georgiana Carp, Victoria Aramă
Introduction: Streptococcal infection can be responsible for multiple complications, such as toxic, septic or allergic disorders. Toxin-mediated complications (TMC) can appear during the acute phase of disease and can involve any organ, causing carditis, arthritis, nephritis, hepatitis etc. Case presentation: The case of a young woman without a history of recurrent streptococcal tonsillitis, admitted to "Matei Balş" National Institute for Infectious Diseases, Bucharest, Romania, presenting with fever, sore throat and exudative tonsillitis, is detailed...
October 2017: Journal of Critical Care Medicine
https://www.readbyqxmd.com/read/29948353/ultrasound-guided-synovial-biopsy-improves-diagnosis-of-septic-arthritis-in-acute-arthritis-without-enough-analyzable-synovial-fluid-a-retrospective-analysis-of-176-arthritis-from-a-french-rheumatology-department
#4
Guillaume Coiffier, Marine Ferreyra, Jean-David Albert, Nathalie Stock, Anne Jolivet-Gougeon, Aleth Perdriger, Pascal Guggenbuhl
To assess the diagnostic value of ultrasound-guided (US-guided) synovial biopsy in routine clinical practice in cases of acute and chronic arthritis. A retrospective, single-center study of US-guided synovial biopsies between 2003 and 2013. The clinical, laboratory, radiographic, synovial fluid, and histological and bacteriological results of synovial biopsies were analyzed. Arthritis was classified according to disease duration < 6 weeks (AA) or ≥ 6 weeks (CA). Synovial biopsy success rate was defined by the rate of capsular and/or synovial tissue analyzed...
August 2018: Clinical Rheumatology
https://www.readbyqxmd.com/read/29943877/pyogenic-arthritis-pyoderma-gangrenosum-and-acne-syndrome-a-rare-but-important-diagnosis-for-antibiotic-resistant-erysipelas-like-erythema-and-osteonecrosis
#5
Giorgia Martini, Alessandra Meneghel, Cosimo Gigante, Valeria Beltrame, Tiziana Serena, Annunziata Di Palma
No abstract text is available yet for this article.
June 26, 2018: Journal of Paediatrics and Child Health
https://www.readbyqxmd.com/read/29915953/two-stage-approach-to-total-knee-arthroplasty-using-colistin-loaded-articulating-cement-spacer-for-vancomycin-resistant-pseudomonas-aeruginosa-infection-in-an-arthritic-knee
#6
REVIEW
Moon Jong Chang, Min Kyu Song, Jae Hoon Shin, Chan Yoon, Chong Bum Chang, Seung-Baik Kang
BACKGROUND: A two-stage approach to total knee arthroplasty (TKA) using an antibiotic-impregnated articulating cement spacer is an option for an infected arthritic knee. Vancomycin combined with broad-spectrum antibiotics can be used to make an antibiotic-impregnated articulating cement spacer. Causative organisms are sometimes not confirmed before surgery. Joint infections of multidrug-resistant organisms are increasing. Therefore, routine combinations of antibiotics may not be effective...
June 18, 2018: European Journal of Orthopaedic Surgery & Traumatology: Orthopédie Traumatologie
https://www.readbyqxmd.com/read/29908523/radiographic-study-of-haematogenous-septic-arthritis-in-dairy-calves
#7
Caroline Constant, Isabelle Masseau, Marie Babkine, Sylvain Nichols, David Francoz, Gilles Fecteau, Emma Marchionatti, Helene Larde, Andre Desrochers
OBJECTIVES:  (1) To develop an evaluation grid to provide a systematic interpretation of calves' articular radiographs, (2) to describe radiographic lesions of septic arthritis in dairy calves less than 6 months of age, (3) to investigate potential associations between demographic data or synovial bacteriological culture results and radiographic lesions (4) to determine whether an association is present between radiographic lesions, their severity and the long-term outcome. METHODS:  Medical records of 54 calves less than 180 days old treated for septic arthritis between 2009 and 2014 with radiographic images performed in the first 2 days after admission were reviewed...
July 2018: Veterinary and Comparative Orthopaedics and Traumatology: V.C.O.T
https://www.readbyqxmd.com/read/29900082/tuberculous-arthritis-of-the-elbow-joint-an-uncommon-location-with-a-diagnostic-dilemma
#8
Neelam Khetpal, Sameen Khalid, Ranjeet Kumar, Manuel F Betancourt, Akash Khetpal, Christopher Wasyliw, Seema Patel
Musculoskeletal tuberculosis accounts for 1%-3% of all cases of tuberculosis (TB) worldwide with elbow involvement being even less common. The most cases of tuberculous arthritis occur in patients born in and emigrated from endemic regions, especially in patients who are co-infected with human immunodeficiency virus (HIV). We present a rare case of tuberculous septic arthritis of the elbow joint in a 78-year-old African-American female from the United States, with no history of travel abroad. Her presenting symptoms included pain, swelling, and decreased range of motion of the right elbow for six months...
April 11, 2018: Curēus
https://www.readbyqxmd.com/read/29859074/update-on-the-risks-of-complications-after-knee-arthroscopy
#9
Katarina Friberger Pajalic, Aleksandra Turkiewicz, Martin Englund
BACKGROUND: Knee arthroscopy is one of the most common surgical procedures worldwide and the number of arthroscopies has substantially increased in the last 30 years. Thus, our aim was to provide updated estimates on the risk of complications and compare it with the background risk in the general population. METHODS: We identified patients aged 15-84 years with knee arthroscopy in the years 2005-2016 in southern Sweden. We calculated the risk of pyogenic arthritis, venous thromboembolism, and other typical complications within 30 days...
June 1, 2018: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29849351/sternoclavicular-septic-arthritis-caused-by-streptococcus-pyogenes-in-a-child
#10
Yenisleidy Paez-Perez, Terrance McGovern, Ashley Flannery, Farid Naim
Septic arthritis can be a devastating condition that leads to further morbidity and potential mortality if not identified early in its course. Emergency providers must keep septic arthritis high on their differential of any joint-related pain in the pediatric population. We present a case of an eight-year-old female who initially presented with the chief complaint of chest pain and was subsequently diagnosed with septic arthritis of the left sternoclavicular joint in the emergency department.
November 2017: Clinical practice and cases in emergency medicine
https://www.readbyqxmd.com/read/29742056/a-dermatologic-perspective-on-autoinflammatory-diseases
#11
REVIEW
Angelo Valerio Marzano, Giovanni Damiani, Giovanni Genovese, Marco Gattorno
Autoinflammatory diseases (AIDs) encompass a heterogeneous group of disorders pathogenetically related to an abnormal activation of the innate immunity and clinically characterised by aseptic inflammation in the affected organs in the absence of high titer of circulating autoantibodies or autoreactive T cells. In classic monogenic AIDs, the skin is frequently involved with a wide range of cutaneous lesions. Monogenic AIDs result from different mutations in a single gene, which regulates the innate immunity...
January 2018: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/29728840/evaluation-of-the-current-use-of-imaging-modalities-and-pathogen-detection-in-children-with-acute-osteomyelitis-and-septic-arthritis
#12
Nora Manz, Andreas H Krieg, Ulrich Heininger, Nicole Ritz
Diagnostic tools for the management of acute osteomyelitis (OM) and septic arthritis (SA) have improved over the last decade. To investigate the influence and availability of magnetic resonance imaging (MRI) and nucleic acid testing (NAT), a retrospective cohort study was done. Patients admitted with acute OM or SA between 2005 and 2014 were identified using ICD-10 discharge codes. Ninety-six children were identified: OM, n = 45; SA, n = 42; and OM + SA, n = 9. Diagnostic imaging was performed in 100% of OM or OM + SA and 95% of SA patients...
July 2018: European Journal of Pediatrics
https://www.readbyqxmd.com/read/29643731/childhood-pyogenic-osteomyelitis-in-abakaliki-south-east-nigeria
#13
Njoku Isaac Omoke
Background: Pyogenic osteomyelitis is an important child health problem in developing countries. It is a one-disease state with a spectrum of pathological features and clinical forms ranging from acute to chronic presentation. Its pattern of presentation varies from and within subregions. The aim of this study was to determine the pattern and outcome of childhood pyogenic osteomyelitis in a low-resource environment. Materials and Methods: This was a retrospective study of all the children aged 18 years and under seen with pyogenic osteomyelitis in Federal Teaching Hospital Abakaliki between January 2005 and December 2015...
January 2018: Nigerian Journal of Surgery: Official Publication of the Nigerian Surgical Research Society
https://www.readbyqxmd.com/read/29408886/contribution-of-bacterial-pathogens-to-evoking-serological-disease-markers-and-aggravating-disease-activity-in-rheumatoid-arthritis
#14
Kuniaki Terato, Takaki Waritani, Richio Fukai, Hiroshi Shionoya, Hiroshi Itoh, Kou Katayama
Commensal bacteria and their pathogenic components in the gastrointestinal tract and oral cavity may play pathological roles in autoimmune diseases. To study the possible involvement of bacterial pathogens in autoimmune diseases, IgG and IgA antibodies against pathogenic components produced by three strains of commensal bacteria, Escherichia coli-lipopolysaccharide (E. coli-LPS), Porphyromonas gingivalis-LPS (Pg-LPS) and peptidoglycan polysaccharide (PG-PS) from Streptococcus pyogenes, were determined by an improved ELISA system for sera from two groups of patients with rheumatoid arthritis (RA), who met rapid radiographic progression (RRP) criteria and non-RRP, and compared to normal (NL) controls...
2018: PloS One
https://www.readbyqxmd.com/read/29361346/novel-antibiotic-loaded-cement-femoral-head-spacer-for-the-treatment-of-advanced-pyogenic-arthritis-in-adult-hip
#15
Yoon Je Cho, Dhrumil Patel, Young Soo Chun, Won Ju Shin, Kee Hyung Rhyu
BACKGROUND: The aim of this study is to present a treatment for end-stage pyogenic arthritis of the hip using a novel cement spacer. This spacer caused less damage to the proximal femoral bone and made the conversion to total hip arthroplasty (THA) more convenient while maintaining the advantages of current cement spacers loaded with antibiotics. METHODS: We retrospectively reviewed 10 consecutive cases of hip pyogenic arthritis with joint destruction. These cases occurred from September 2009 to June 2015...
June 2018: Journal of Arthroplasty
https://www.readbyqxmd.com/read/29351806/isolated-septic-arthritis-of-hip-joint-a-rare-presentation-of-melioidosis-a-case-report
#16
N P Weerasinghe, H M M Herath, T M U Liyanage
BACKGROUND: Despite, Sri Lanka lies in the melioidosis endemic belt between 5°N and 10°N surrounded by countries known to have endemic melioidosis for many years, comparatively fewer cases of melioidosis infection have been reported in Sri Lanka. Melioidosis has a wide spectrum of clinical presentation, ranging from severe pneumonia to abscess formation in various organs. Isolated septic arthritis, which is a rare but well-recognized manifestation of melioidosis, could be the sole presenting problem in some patients with melioidosis...
January 19, 2018: BMC Research Notes
https://www.readbyqxmd.com/read/29305995/acute-septic-arthritis-of-the-knee-a-rare-case-report-of-infection-with-parvimonas-micra-after-an-intra-articular-corticosteroid-injection-for-osteoarthritis
#17
Assem A Sultan, William A Cantrell, Anton Khlopas, Connor Cole, Nicolas S Piuzzi, Nipun Sodhi, Peter Brooks, Michael A Mont
Acute bacterial mono-articular septic arthritis affects most commonly the lower extremity joints in adult population and most commonly caused by Staphylococcus aureus. Various risk factors determine susceptibility to infection including host immunity, medical co-morbidity and joint structural abnormality and other organisms may be involved. Parvimonas micra (P. micra) is among the rare organisms that may be associated with atypical septic arthritis and primarily affects the native knee joint. Only 3 case reports in the literature have reported on pyogenic pyogenic joint infection caused by this organism...
June 2018: Anaerobe
https://www.readbyqxmd.com/read/29274860/primary-pyomyositis-in-children
#18
M M Elzohairy
BACKGROUND: Pyomyositis (PM) is defined as a primary pyogenic infection of the striated skeletal muscle; although it has many dystrophic musculoskeletal complications, it is always misdiagnosed by many orthopedic surgeons. HYPOTHESIS: PM is rare in temperate climates and usually considered to be a tropical disease, until recent times, after globalization, it is possible to occur in the subtropical climate as in our country. MATERIAL AND METHODS: In the present series, the results of 15 children patients with primary pyomyositis have been reviewed...
May 2018: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/29081854/toxic-shock-in-children-with-bone-and-joint-infections-a-review-of-seven-years-of-patients-admitted-to-one-intensive-care-unit
#19
D L Kerr, E K Loraas, A C Links, T V Brogan, G A Schmale
PURPOSE: The objective of this study was to compare the frequency of severe systemic, multi-organ involvement and toxic shock syndrome (TSS) in patients with Staphylococcus aureus (SA) and Group A β-haemolytic Streptococcus pyogenes (GABS) bone and joint infections. METHODS: We retrospectively reviewed patients treated for septic arthritis or osteomyelitis at one children's hospital between 2002 and 2009. The rates of intensive care unit (ICU) admission for methicillin-sensitive SA (MSSA), methicillin-resistant SA (MRSA) and GABS infections were compared, as were the lengths of stay, number of surgeries, operative procedures and cases of TSS...
October 1, 2017: Journal of Children's Orthopaedics
https://www.readbyqxmd.com/read/29075910/pyoderma-gangrenosum-and-pyogenic-arthritis-presenting-as-severe-sepsis-in-a-rheumatoid-arthritis-patient-treated-with-golimumab
#20
REVIEW
Anastasia Skalkou, Sofia-Magdalini Manoli, Alexandros Sachinidis, Vasilios Ntouros, Konstantinos Petidis, Eleni Pagkopoulou, Efstratios Vakirlis, Athina Pyrpasopoulou, Theodoros Dimitroulas
Rheumatoid arthritis is a systemic autoimmune disease resulting in joint destruction and deformities, but also associated with extraarticular and systemic manifestations. The later devastating conditions, such as the development of rheumatoid vasculitis, are more frequently encountered in seropositive patients and their incidence has been attenuated after the introduction of biologic disease modifying drugs, such as anti-tumor necrosis factor alpha (TNFa) agents, which generally have considerably contributed to the better control and long-term outcomes of the disease...
January 2018: Rheumatology International
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