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Testosterone deficiency

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https://www.readbyqxmd.com/read/28097272/erratum-correction-of-the-references-for-figures-testosterone-therapy-in-men-with-testosterone-deficiency-are-we-beyond-the-point-of-no-return
#1
Abdulmaged Traish
[This corrects the article on p. 384 in vol. 57.].
January 2017: Investigative and Clinical Urology
https://www.readbyqxmd.com/read/28090714/transplantation-of-cd51-stem-leydig-cells-a-new-strategy-for-the-treatment-of-testosterone-deficiency
#2
Zhi Jun Zang, Jiancheng Wang, Zhihong Chen, Yan Zhang, Yong Gao, Zhijian Su, Ying Tuo, Yan Liao, Min Zhang, Qunfang Yuan, Chunhua Deng, Mei Hua Jiang, Andy Peng Xiang
Stem Leydig cell (SLC) transplantation could provide a new strategy for treating the testosterone deficiency. Our previous study demonstrated that CD51 (also called integrin αv) might be a putative cell surface marker for SLCs, but the physiological function and efficacy of CD51(+) SLCs treatment remain unclear. Here, we explore the potential therapeutic benefits of CD51(+) SLCs transplantation and whether these transplanted cells can be regulated by the hypothalamic-pituitary-gonadal (HPG) axis. CD51(+) cells were isolated from the testes of 12-weeks-old C57BL/6 mice, and we showed that such cells expressed SLC markers and that they were capable of self-renewal, extensive proliferation, and differentiation into multiple mesenchymal cell lineages and LCs in vitro...
January 16, 2017: Stem Cells
https://www.readbyqxmd.com/read/28086774/androgenic-effects-of-aqueous-and-methanolic-extracts-of-ficus-asperifolia-in-male-wistar-rats
#3
Pierre Watcho, Hermine Meli Watio, Modeste Wankeu-Nya, Esther Ngadjui, Patrick Deeh Defo, Pepin Alango Nkeng-Efouet, Telesphore Benoit Nguelefack, Albert Kamanyi
BACKGROUND: Androgen deficiency is a clinical syndrome resulting from the inability of the testes to produce physiological levels of testosterone due to a disturbance occurring at one or more levels of the hypothalamic-pituitary-testicular axis. The present study was undertaken to evaluate the androgenic properties of aqueous and methanolic extracts of Ficus asperifolia on normal and castrated immature rats. METHODS: Normal rats were treated either per os with aqueous or methanolic extract of Ficus asperifolia (100 mg/kg or 500 mg/kg b...
January 13, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28078216/testosterone-replacement-therapy-role-of-pituitary-and-thyroid-in-diagnosis-and-treatment
#4
REVIEW
Megan Crawford, Laurence Kennedy
Crosstalk among hormones characterizes endocrine function, and assessment of the hypogonadal man should take that into consideration. In men for whom testosterone deficiency is a concern, initial evaluation should include a thorough history and physical exam in which other endocrinopathies are being considered. Hypogonadism can be associated with both pituitary and thyroid dysfunction, for which appropriate biochemical evaluation should be undertaken in certain clinical scenarios. If low serum testosterone is confirmed measurement of luteinizing and follicle stimulating hormones (LH and FSH respectively) is essential to establish whether the hypogonadism is primary or secondary...
December 2016: Translational Andrology and Urology
https://www.readbyqxmd.com/read/28078213/adult-onset-hypogonadism-evaluation-and-role-of-testosterone-replacement-therapy
#5
REVIEW
Andrew J Davidiuk, Gregory A Broderick
Testosterone deficiency (TD) has become a growing concern in the field of men's sexual health, with an increasing number of men presenting for evaluation of this condition. Given the increasing demand for testosterone replacement therapy (TRT), a panel of experts met in August of 2015 to discuss the treatment of men who present for evaluation in the setting of low or normal gonadotropin levels and the associated signs and symptoms of hypogonadism. This constellation of factors can be associated with elements of both primary and secondary hypogonadism...
December 2016: Translational Andrology and Urology
https://www.readbyqxmd.com/read/28074679/vitamin-d-treatment-improves-levels-of-sexual-hormones-metabolic-parameters-and-erectile-function-in-middle-aged-vitamin-d-deficient-men
#6
Onder Canguven, Raidh A Talib, Walid El Ansari, Dany-Jan Yassin, Abdullah Al Naimi
BACKGROUND: The associations between serum vitamin D (VD), serum testosterone (TT) and metabolic syndrome are complex and with limited published research, particularly on the effects of VD treatment on sexual hormones, erectile function and the metabolic syndrome. OBJECTIVES: This study assessed whether a monthly high dose VD treatment for 12 months in VD deficient middle-aged men was associated with: changes in levels of sexual hormones, improvement of diabetes control and metabolic syndrome components, better erectile function [International Index of Erectile Function (IIEF)-5 questionnaire]; and changes in a prostate marker...
January 11, 2017: Aging Male: the Official Journal of the International Society for the Study of the Aging Male
https://www.readbyqxmd.com/read/28070708/delayed-treatment-of-undescended-testes-may-promote-hypogonadism-and-infertility
#7
Julia Rohayem, Alessandra Luberto, Eberhard Nieschlag, Michael Zitzmann, Sabine Kliesch
CONTEXT: Undescended testes at birth may be caused by testosterone deficiency during fetal development. It is unclear whether the process of failed descent contributes to permanent endocrine impairment. OBJECTIVES: To evaluate the impact of age at treatment of undescended testes on endocrine and spermatogenic testicular function in middle-aged men. PATIENTS AND METHODS: Reproductive hormone and semen data of 357 men with previously undescended testes were evaluated with respect to age at correction of testicular position and compared to those of 709 controls with eutopic testes at birth and normozoospermia...
January 9, 2017: Endocrine
https://www.readbyqxmd.com/read/28065637/the-steroid-metabolite-16-%C3%AE-oh-androstenedione-generated-by-cyp21a2-serves-as-a-substrate-for-cyp19a1
#8
J Neunzig, M Milhim, L Schiffer, Y Khatri, J Zapp, A Sánchez-Guijo, M F Hartmann, S A Wudy, R Bernhardt
The 21-hydroxylase (CYP21A2) is a steroidogenic enzyme crucial for the synthesis of mineralo- and glucocorticoids. It is described to convert progesterone as well as 17-OH-progesterone, through a hydroxylation at position C21, into 11-deoxycorticosterone (DOC) and 11-deoxycortisol (RSS), respectively. In this study we unraveled CYP21A2 to have a broader steroid substrate spectrum than assumed. Utilizing a reconstituted in vitro system, consisting of purified human CYP21A2 and human cytochrome P450 reductase (CPR) we demonstrated that CYP21A2 is capable to metabolize DOC, RSS, androstenedione (A4) and testosterone (T)...
January 5, 2017: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/28053949/effect-of-testosterone-replacement-therapy-on-cognitive-performance-and-depression-in-men-with-testosterone-deficiency-syndrome
#9
Hyun Jin Jung, Hong Seok Shin
PURPOSE: We aimed to evaluate the effect of testosterone replacement therapy (TRT) on cognitive function and depression in men with testosterone deficiency syndrome. MATERIALS AND METHODS: We carried out a prospective, placebo-controlled trial involving 106 men with total testosterone levels <3.3 ng/mL and symptoms of hypogonadism. Based on whether the patients received TRT (injection with 1,000 mg testosterone undecanoate) or a placebo (advice to modify lifestyle), the study population was divided into a TRT group (n=54) and a control group (n=52)...
December 2016: World Journal of Men's Health
https://www.readbyqxmd.com/read/28041602/serum-vitamin-d-and-sex-hormones-levels-in-men-and-women-the-multi-ethnic-study-of-atherosclerosis-mesa
#10
Di Zhao, Pamela Ouyang, Ian H de Boer, Pamela L Lutsey, Youssef M K Farag, Eliseo Guallar, David S Siscovick, Wendy S Post, Rita R Kalyani, Kevin L Billups, Erin D Michos
INTRODUCTION: 25-hydroxyvitamin D [25(OH)D] deficiency has been associated with low testosterone levels in men, but there are conflicting reports of its associations with sex hormones in women. Less is known about whether these associations are independent of adiposity and lifestyle factors, and whether they differ by race/ethnicity. AIM: To examine associations of 25(OH)D concentrations with sex hormone levels. METHODS: Cross-sectional analysis of 3017 men and 2929 women in a multi-ethnic cohort...
February 2017: Maturitas
https://www.readbyqxmd.com/read/28031016/androgen-deficiency-in-aging-male-questionnaire-for-the-clinical-detection-of-testosterone-deficiency-in-a-population-of-black-sub-saharan-african-men-with-type-2-diabetes-mellitus-is-it-a-reliable-tool
#11
Ejiofor T Ugwu, Rosemary T Ikem
BACKGROUND: Androgen Deficiency in Aging Male (ADAM) questionnaire is increasingly popular for the evaluation of testosterone deficiency (TD) in Sub-Saharan African men with type 2 diabetes mellitus (T2DM). However, its reliability in this population is unknown. OBJECTIVE: To evaluate the reliability of the ADAM questionnaire for the clinical detection of testosterone deficiency in Sub-Saharan African men with T2DM Methods: Total testosterone < 8nmol/L was used as gold standard for diagnosis of TD in a cross-sectional survey of 200 males with T2DM aged 30-69 years...
December 28, 2016: Current Diabetes Reviews
https://www.readbyqxmd.com/read/28028318/symptomatic-response-to-testosterone-treatment-in-dieting-obese-men-with-low-testosterone-levels-in-a-randomized-placebo-controlled-clinical-trial
#12
M N T Fui, R Hoermann, L A Prendergast, J D Zajac, M Grossmann
BACKGROUND: Obese men commonly have reductions in circulating testosterone and report symptoms consistent with androgen deficiency. We hypothesized that testosterone treatment improves constitutional and sexual symptoms over and above the effects of weight loss alone. METHODS: We conducted a pre-specified analysis of a randomized double-blind, placebo-controlled trial at a tertiary referral centre. 100 obese men (BMI>30 kg/m(2)) with a repeated total testosterone level <12 nmol/l and a median age of 53 years (interquartile range 47-60) receiving 10 weeks of a very low energy diet (VLED) followed by 46 weeks of weight maintenance were randomly assigned at baseline to 56 weeks of intramuscular testosterone undecanoate (n=49, cases) or matching placebo (n=51, controls)...
December 28, 2016: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/28026037/relative-contributions-of-testosterone-deficiency-and-metabolism-syndrome-at-the-risk-of-reduced-quality-of-life-a-cross-sectional-study-among-chinese-mid-aged-and-elderly-men
#13
X R Qing, C C Wan, X J Shang, H G Li, C L Xiong, X X Zhan, D S Mo, H C Cai, H P Zhang, H T Guan, X B Kong, Y P Chen, T H Liu, B J Hao, S Y Zong
Testosterone deficiency and metabolism syndrome (MetS) are universal among ageing males, and they have been suggested responsible for poorer quality of life (QoL). We aimed to evaluate the relative contributions of reproductive hormones and components of MetS at the risk of reduced QoL among Chinese mid-aged and elderly men. A cross-sectional study recruited 2,364 males aged 40-79 years, and 2,165 was included for analysis eventually. The Chinese version of ageing male symptoms scale, 36-item Short Form and Beck Depression Inventory were applied to assess QoL...
December 27, 2016: Andrologia
https://www.readbyqxmd.com/read/28008861/delayed-diagnosis-of-a-17-hydroxylase-17-20-lyase-deficient-case-presented-with-46-xy-female-low-normal-potassium-can-alert-clinician
#14
Emine Çamtosun, Zeynep Şıklar, Serdar Ceylaner, Pınar Kocaay, Merih Berberoğlu
17-hydroxylase/17,20-lyase deficiency (17OHD) is a rare autosomal recessive defect in adrenal and gonadal steroidogenesis, causes absence of secondary sexual characteristics frequently associated with hypertension and hyperkalemia. Here we report a 46, XY case, who had normal potassium levels and without hypertension. Here we present a 2,5 years old female admitted with female external genitalia and inguinal swelling. Pathology of biopsy revealed that this gonad is a testis. Karyotype was 46, XY. She had no hypertension and no hypokalemia...
December 23, 2016: Journal of Clinical Research in Pediatric Endocrinology
https://www.readbyqxmd.com/read/28008293/hormonal-and-echocardiographic-abnormalities-in-adult-patients-with-sickle-cell-anemia-in-bahrain
#15
Taysir S Garadah, Ahmed A Jaradat, Mohammed E Alalawi, Adla B Hassan
BACKGROUND: Adrenal, thyroid, and parathyroid gland hormonal changes are recognized in children with homozygous (HbSS) sickle-cell anemia (SCA), but are not clear in adult patients with SCA. AIM: To assess the metabolic and endocrine abnormalities in adult patients with SCA and evaluate left ventricular (LV) systolic and diastolic functions compared with patients with no SCA and further study the relationship between serum levels of cortisol, free thyroxine (T4), and testosterone with serum ferritin...
2016: Journal of Blood Medicine
https://www.readbyqxmd.com/read/28003536/deficient-melanocortin-4-receptor-causes-abnormal-reproductive-neuroendocrine-profile-in-female-mice
#16
Xiaolin Chen, Lili Huang, Hwee Y Tan, Hongzhuo Li, Ying Wan, Michael Cowley, Johannes D Veldhuis, Chen Chen
Deletion of the melanocortin-4-receptor (Mc4r) gene in mice causes hyperphagia, followed by hyperinsulinemia, obesity and progressive infertility. Evidence shows that the number of developed corpora lutea is reduced in obese MC4R-knockout (MC4R KO) female mice, but the mechanism is unclear. The effect of hyperphagia and obesity by MC4R KO on pulsatile luteinizing hormone (LH) secretion and ovulation remains unknown. In MC4R KO mice and wild-type littermates (WT LM) during the diestrus period throughout different ages, we examined and monitored their metabolic status, pulsatile LH profiles, follicular morphology and the number of corpora lutea...
March 2017: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/27999286/testosterone-deficiency-induces-changes-of-the-transcriptomes-of-visceral-adipose-tissue-in-miniature-pigs-fed-a-high-fat-and-high-cholesterol-diet
#17
Lifan Zhang, Yueqin Cai, Shengjuan Wei, Yun Ling, Liang Zhu, Dongfeng Li, Zhaowei Cai
Testosterone deficiency causes fat deposition, particularly in visceral fat, and its replacement might reverse fat accumulation, however, the underlying mechanisms of such processes under diet-induced adiposity are largely unknown. To gain insights into the genome-wide role of androgen on visceral adipose tissue (VAT), RNA-Seq was used to investigate testosterone deficiency induced changes of VAT in miniature pigs fed a high-fat and high-cholesterol (HFC) diet among intact male pigs (IM), castrated male pigs (CM), and castrated male pigs with testosterone replacement (CMT) treatments...
December 16, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27998231/hypothalamic-pituitary-axis-dysfunction-in-survivors-of-childhood-cns-tumors-importance-of-systematic-follow-up-and-early-endocrine-consultation
#18
Wassim Chemaitilly, Gregory T Armstrong, Amar Gajjar, Melissa M Hudson
The Oncology Grand Rounds series is designed to place original reports published in the Journal into clinical context. A case presentation is followed by a description of diagnostic and management challenges, a review of the relevant literature, and a summary of the authors' suggested management approaches. The goal of this series is to help readers better understand how to apply the results of key studies, including those published in Journal of Clinical Oncology, to patients seen in their own clinical practice...
December 20, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/27988267/poor-sleep-quality-predicts-hypogonadal-symptoms-and-sexual-dysfunction-in-male-nonstandard-shift-workers
#19
Alexander W Pastuszak, Young M Moon, Jason Scovell, Justin Badal, Dolores J Lamb, Richard E Link, Larry I Lipshultz
OBJECTIVE: To investigate the impact of sleep quality in hypogonadal symptoms and sexual function in men working nonstandard shifts. MATERIALS AND METHODS: Men treated at a single andrology clinic between July and October 2014 completed questionnaires assessing sleep quality, hypogonadal symptoms (Androgen Deficiency in the Aging Male [ADAM/qADAM]), and sexual function (International Index of Erectile Function [IIEF]). Serum hormone levels were assessed at the time of survey completion...
December 14, 2016: Urology
https://www.readbyqxmd.com/read/27983628/the-effects-of-annatto-tocotrienol-on-bone-biomechanical-strength-and-bone-calcium-content-in-an-animal-model-of-osteoporosis-due-to-testosterone-deficiency
#20
Kok-Yong Chin, Dhivakaran Gengatharan, Fadlin Sakina Mohd Nasru, Rehan Amalia Khairussam, Sherlyn Lai Hui Ern, Siti Aina Wahidah Aminuddin, Soelaiman Ima-Nirwana
Osteoporosis reduces the skeletal strength and increases the risk for fracture. It is an underdiagnosed disease in men. Annatto tocotrienol has been shown to improve bone structural indices and increase expression of bone formation genes in orchidectomized rats. This study aimed to evaluate the effects of annatto tocotrienol on biomechanical strength and calcium content of the bone in orchidectomized rats. Thirty three-month-old male Sprague-Dawley rats were randomly assigned to five groups. The baseline control (BC) group was sacrificed at the onset of the study...
December 14, 2016: Nutrients
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