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Testosterone deficiency

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https://www.readbyqxmd.com/read/29895006/the-metabolic-syndrome-in-central-hypogonadotrophic-hypogonadism
#1
Andrew A Dwyer, Richard Quinton
The metabolic syndrome (MetS) is a term used to describe the constellation of cardiometabolic risk factors including central adiposity, dyslipidemia, insulin resistance, non-alcoholic fatty liver disease and arterial hypertension. Notably, a number of studies have shown high rates of testosterone (T) deficiency in men with MetS and type 2 diabetes mellitus (T2DM). Both hypogonadism and MetS confer increased health risk for morbidity and mortality as men with the MetS are at twice the risk for developing cardiovascular disease and at 5-fold higher risk for developing T2DM...
2018: Frontiers of Hormone Research
https://www.readbyqxmd.com/read/29894840/slow-wave-sleep-and-androgens-selective-slow-wave-sleep-suppression-affects-testosterone-and-17%C3%AE-hydroxyprogesterone-secretion
#2
Yu V Ukraintseva, K M Liaukovich, А A Polishchuk, О V Martynova, D A Belov, E S Simenel, М Meira E Cruz, А N Nizhnik
OBJECTIVES: Levels of steroid hormones such as androgens and cortisol exhibit circadian variation, and their fluctuations are related to the sleep-wake cycle. Currently, the functional role of different stages of sleep in steroid hormone secretion remains unclear. The present study aims to explore the effect of slow-wave sleep (SWS) suppression on morning levels of cortisol and androgens. METHODS: Twelve healthy male volunteers participated in two experimental sessions: a session with selective SWS suppression during night sleep and a session with regular night sleep (control)...
May 12, 2018: Sleep Medicine
https://www.readbyqxmd.com/read/29890654/cross-sectional-inverse-associations-of-obesity-and-fat-accumulation-indicators-with-testosterone-in-non-diabetic-aging-men
#3
Iwona Rotter, Aleksandra Rył, Katarzyna Grzesiak, Aleksandra Szylińska, Wioletta Pawlukowska, Anna Lubkowska, Olimpia Sipak-Szmigiel, Krzysztof Pabisiak, Maria Laszczyńska
Introduction/Objective : The aim of the study was to show which of the adipose tissue accumulation indicators correlate with testosterone disorders in non-diabetic aging men. Material and methods : 455 non diabetic men, recruited at primary care facilities, aged 50⁻75 participated in the study. The participants underwent anthropometric measurement and ELISA determination of total testosterone (TT), estradiol (E₂), dehydroepiandrosterone sulphate (DHEA-S), sex hormone binding protein (SHBG), and the determination of fasting glucose (FPG), high-density lipids cholesterol (HDL-Ch), and triacylglycerols (TAG) in serum...
June 8, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29890281/mechanisms-of-testosterone-deficiency-related-endothelial-dysfunction
#4
EDITORIAL
Alexios S Antonopoulos, Charalambos Antoniades
Evidence from clinical studies suggests that patients with low testosterone levels are at increased cardiovascular disease risk. Even though the exact mechanisms remain poorly understood, low plasma testosterone is associated with a pro-atherogenic lipid profile, insulin resistance and increased levels of pro-inflammatory mediators, and vascular dysfunction which is typically observed in patients with hypogonadism. Furthermore, recent evidence suggests that testosterone deficiency has also direct adverse effects on endothelium and nitric oxide bioavailability...
June 8, 2018: Hellenic Journal of Cardiology: HJC, Hellēnikē Kardiologikē Epitheōrēsē
https://www.readbyqxmd.com/read/29874225/nestin-in-the-epididymis-is-expressed-in-vascular-wall-cells-and-is-regulated-during-postnatal-development-and-in-case-of-testosterone-deficiency
#5
Ansgar N Reckmann, Claudia U M Tomczyk, Michail S Davidoff, Tatyana V Michurina, Stefan Arnhold, Dieter Müller, Andrea Mietens, Ralf Middendorff
Vascular smooth muscle cells (SMCs), distinguished by the expression of the neuronal stem cell marker nestin, may represent stem cell-like progenitor cells in various organs including the testis. We investigated epididymal tissues of adult nestin-GFP mice, rats after Leydig cell depletion via ethane dimethane sulfonate (EDS), rats and mice during postnatal development and human tissues. By use of Clarity, a histochemical method to illustrate a three-dimensional picture, we could demonstrate nestin-GFP positive cells within the vascular network...
2018: PloS One
https://www.readbyqxmd.com/read/29858846/5-%C3%AE-reductase-type-2-deficiency-is-there-a-genotype-phenotype-correlation-a-review
#6
REVIEW
Andrea Avendaño, Irene Paradisi, Francisco Cammarata-Scalisi, Michele Callea
5-α-Reductase type 2 enzyme catalyzes the conversion of testosterone into dihydrotestosterone, a potent androgen responsible for male sexual development during the fetal period and later during puberty. Its deficiency causes an autosomal recessive disorder of sex development characterized by a wide range of under-virilization of external genitalia in patients with a 46,XY karyotype. Mutations in the SRD5A2 gene cause 5-α-Reductase deficiency; although it is an infrequent disorder, it has been reported worldwide, with mutational heterogeneity...
April 20, 2018: Hormones: International Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29844497/kcne4-deletion-sex-specifically-predisposes-to-cardiac-arrhythmia-via-testosterone-dependent-impairment-of-risk-safe-pathway-induction-in-aged-mice
#7
Zhaoyang Hu, Wei Wei, Leng Zhou, Mou Chen, Geoffrey W Abbott
Sudden cardiac death (SCD) is associated with both electrical and ischemic substrates, and is a major cause of ischemic heart disease mortality worldwide. Male sex predisposes to SCD but the underlying mechanisms are incompletely understood. KCNE4, a cardiac arrhythmia-associated potassium channel β-subunit, is upregulated by 5α-dihydrotestosterone (DHT). Thus, ventricular Kcne4 expression is low in young adult female mice, but high in males and postmenopausal (12+ months) females. Despite causing a sex-independent electrical substrate at 13 months of age (22% QT prolongation in both males and females; P < 0...
May 29, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29802242/testosterone-is-an-endogenous-regulator-of-baff-and-splenic-b-cell-number
#8
Anna S Wilhelmson, Marta Lantero Rodriguez, Alexandra Stubelius, Per Fogelstrand, Inger Johansson, Matthew B Buechler, Steve Lianoglou, Varun N Kapoor, Maria E Johansson, Johan B Fagman, Amanda Duhlin, Prabhanshu Tripathi, Alessandro Camponeschi, Bo T Porse, Antonius G Rolink, Hans Nissbrandt, Shannon J Turley, Hans Carlsten, Inga-Lill Mårtensson, Mikael C I Karlsson, Åsa Tivesten
Testosterone deficiency in men is associated with increased risk for autoimmunity and increased B cell numbers through unknown mechanisms. Here we show that testosterone regulates the cytokine BAFF, an essential survival factor for B cells. Male mice lacking the androgen receptor have increased splenic B cell numbers, serum BAFF levels and splenic Baff mRNA. Testosterone deficiency by castration causes expansion of BAFF-producing fibroblastic reticular cells (FRCs) in spleen, which may be coupled to lower splenic noradrenaline levels in castrated males, as an α-adrenergic agonist decreases splenic FRC number in vitro...
May 25, 2018: Nature Communications
https://www.readbyqxmd.com/read/29794984/attenuation-of-metabolic-syndrome-by-epa-dha-ethyl-esters-in-testosterone-deficient-obese-rats
#9
Nikhil S Bhandarkar, Senthil Arun Kumar, Jarad Martin, Lindsay Brown, Sunil K Panchal
Inducing testosterone deficiency, as the standard treatment of prostate cancer, may cause metabolic disorders including insulin resistance, dyslipidemia, central obesity, cardiovascular diseases, and type 2 diabetes. This study measured responses to testosterone deficiency in high-carbohydrate, high-fat (H) diet-fed rats. We then tested whether eicosapentaenoic acid (EPA)/docosahexaenoic acid (DHA) ethyl esters (Omacor) reversed these metabolic changes. Male Wistar rats (8⁻9 weeks old) were divided into eight groups with four groups fed corn starch and four groups fed H diet...
May 24, 2018: Marine Drugs
https://www.readbyqxmd.com/read/29793502/deficiency-of-gpr1-improves-steroid-hormone-abnormality-in-hyperandrogenized-mice
#10
Ya-Li Yang, Li-Feng Sun, Yan Yu, Tian-Xia Xiao, Bao-Bei Wang, Pei-Gen Ren, Hui-Ru Tang, Jian V Zhang
BACKGROUND: Polycystic ovary syndrome (PCOS) is a complex genetic disease with multifarious phenotypes. Many researches use dehydroepiandrosterone (DHEA) to induce PCOS in pubertal mouse models. The aim of this study was to investigate the role of GPR1 in dehydroepiandrosterone (DHEA)-induced hyperandrogenized mice. METHODS: Prepubertal C57BL/6 mice (25 days of age) and Gpr1-deficient mice were each divided into two groups and injected daily with sesame oil with or without DHEA (6 mg/100 g) for 21 consecutive days...
May 24, 2018: Reproductive Biology and Endocrinology: RB&E
https://www.readbyqxmd.com/read/29779488/bisphenol-a-induced-endocrinotoxicity-and-male-reprotoxicopathy-is-modulated-by-the-dietary-iron-deficiency
#11
Hina Rashid, Shikha Sharma, Saba Beigh, Firoz Ahmad, Sheikh Raisuddin
INTRODUCTION: Bisphenol A (BPA) is suspected to cause hormonal imbalance in humans. Dietary factors are known to bring changes in hormonal profile. In order to study chemico-biological interaction of iron deficiency on toxicity outcome of BPA exposure, we studied the modulatory effects of iron deficiency on the hormone levels in rats chronically-exposed to BPA. METHODS: Weanling rats maintained on normal and iron-deficient diets were exposed to low level of BPA at 0, 1, 5 and 10 ppm for six months through drinking water...
May 20, 2018: Endocrine, Metabolic & Immune Disorders Drug Targets
https://www.readbyqxmd.com/read/29774669/obstructive-sleep-apnea-and-testosterone-deficiency
#12
REVIEW
Sung Dong Kim, Kyu Sup Cho
Obstructive sleep apnea (OSA) is a common disorder characterized by intermittent hypoxia and sleep fragmentation. OSA in middle-aged men is often associated with decreased testosterone secretion, together with obesity and aging. Although OSA treatment does not reliably increase testosterone levels in most studies, OSA treatment with testosterone replacement therapy (TRT) may not only improve hypogonadism, but can also alleviate erectile/sexual dysfunction. However, because TRT may exacerbate OSA in some patients, patients should be asked about OSA symptoms before and after starting TRT...
May 16, 2018: World Journal of Men's Health
https://www.readbyqxmd.com/read/29772111/clomiphene-citrate-and-human-chorionic-gonadotropin-are-both-effective-in-restoring-testosterone-in-hypogonadism-a-short-course-randomised-study
#13
Mohamad Habous, Simone Giona, Alaa Tealab, Mohammed Aziz, Ben Williamson, Mohammed Nassar, Zeyad Abdelrahman, Abdallah Remeah, Mohamed Abdelkader, Saleh Binsaleh, Gordon Muir
OBJECTIVES: To compare serum testosterone response and symptom improvement in hypogonadal men in response to treatment by one of three options: clomiphene citrate(CC), human chorionic gonadotropin (hCG), or combination of both therapy. PATIENTS AND METHODS: 282 hypogonadal adult, willing to preserve their fertility, were randomised in three arms treated respectively with: 50 mg of (CC) (n=95), 5000IU of hCG injections twice a week(n=94) or combination of both therapy(n=94)...
May 17, 2018: BJU International
https://www.readbyqxmd.com/read/29765521/long-term-deficiency-of-vitamin-d-in-germ-cell-testicular-cancer-survivors
#14
Lucia Nappi, Margaret Ottaviano, Pasquale Rescigno, Ladan Fazli, Martin E Gleave, Vincenzo Damiano, Sabino De Placido, Giovannella Palmieri
Background: Cisplatin-based chemotherapy significantly improved the survival of patients with germ cell testicular cancer. However, long term side effects of chemotherapy have non-negligible impact on the quality of life of these young patients, who have a long life expectancy after being successfully treated. Materials and Methods: 25-OH vitamin D, testosterone, FSH and LH of patients with testicular cancer were retrospectively evaluated and for each patient clinical information were collected...
April 20, 2018: Oncotarget
https://www.readbyqxmd.com/read/29756416/testosterone-and-sarcopenia
#15
REVIEW
Myung Jun Shin, Yun Kyung Jeon, In Joo Kim
Aging affects metabolism, leading to physiological and functional impairments, and is also related to changes in body composition, including reduced skeletal muscle mass and increased body fat. These changes are correlated with the pathophysiology of sarcopenia, which is defined as age-related loss of skeletal muscle mass and strength. Low testosterone levels are associated with unfavorable body composition changes, and sex hormones decrease with aging. Androgen deficiency, along with lack of exercise and poor nutrition, may be among the modifiable contributors to sarcopenia...
May 11, 2018: World Journal of Men's Health
https://www.readbyqxmd.com/read/29745000/impacts-of-serum-25-oh-vitamin-d-level-on-lower-urinary-tract-symptoms-in-male-a-step-forward-to-decrease-overactive-bladder
#16
Sangjun Yoo, Sohee Oh, Hyung Suk Kim, Han Seok Choi, Juhyun Park, Sung Yong Cho, Hwancheol Son, Hyeon Jeong, Hae Won Lee, Min Chul Cho
OBJECTIVES: To evaluate the impacts of serum vitamin D level on male lower urinary tract symptoms (LUTS). MATERIALS AND METHODS: From 2014 to 2017, 434 male patients with LUTS were included. The impacts of vitamin D on LUTS were evaluated using multivariate analysis to adjust for age, body mass index, prostate specific antigen, testosterone, Hemoglobin A1c, physical activity, and prostate volume. To exclude the effect of seasons, we also analyzed the impacts during each season...
May 9, 2018: BJU International
https://www.readbyqxmd.com/read/29744905/insulin-resistance-and-sex-hormone-binding-globulin-are-independently-correlated-with-low-free-testosterone-levels-in-obese-males
#17
P Souteiro, S Belo, S C Oliveira, J S Neves, D Magalhães, J Pedro, R Bettencourt-Silva, M M Costa, A Varela, J Queirós, P Freitas, D Carvalho
Male obesity is associated with decreased testosterone levels but the pathophysiological mechanisms behind this association are not completely understood. This study aimed to investigate the impact of hyperglycaemia/insulin resistance and sex hormone-binding globulin (SHBG) levels on testosterone levels in a population of obese men. We investigated the impact of several clinical, anthropometric and analytic measures on testosterone levels in 150 obese males. Testosterone deficiency was present in 52.0% of the enrolled patients...
May 9, 2018: Andrologia
https://www.readbyqxmd.com/read/29733810/testosterone-alleviates-mitochondrial-ros-accumulation-and-mitochondria-mediated-apoptosis-in-the-gastric-mucosa-of-orchiectomized-rats
#18
Jie Kang, Zhenhua Jia, Yang Ping, Zengxiang Liu, Xiaohong Yan, Guozhang Xing, Wensheng Yan
The effects of testosterone propionate (TP) on the oxidative stress and mitochondrial function, as well as on mitochondria associated apoptotic signaling, were analyzed in the gastric mucosa in orchiectomized male rats. The present study showed that testosterone deficiency triggered apoptosis by damaging the mitochondrial function (ROS overload generation, membrane potential loss, ATP depletion, etc.), increasing both the release of mitochondrial cytochrome c (Cyt c) and the Bax/Bcl-2 ratio, and activating caspase-9 and caspase-3...
May 4, 2018: Archives of Biochemistry and Biophysics
https://www.readbyqxmd.com/read/29729005/can-the-positive-association-of-osteocalcin-with-testosterone-be-unmasked-when-the-preeminent-hypothalamic-pituitary-regulation-of-testosterone-production-is-impaired-the-model-of-spinal-cord-injury
#19
A Barbonetti, S D'Andrea, J Samavat, A Martorella, G Felzani, S Francavilla, M Luconi, F Francavilla
PURPOSE: Osteocalcin (OCN), released from the bone matrix during the resorption phase, in its undercarboxylated form, stimulates testosterone (T) biosynthesis in mouse and a loss-of-function mutation of its receptor was associated with hypergonadotropic hypogonadism in humans. Nevertheless, when population-based studies have explored the OCN-T association, conflicting results have been reported. Hypothesizing that the evidence of a positive association between OCN and T could have been hindered by the preeminent role of a well-functioning hypothalamus-pituitary axis in promoting T biosynthesis, we explored this association in men with chronic spinal cord injury (SCI), exhibiting high prevalence of non-hypergonadotropic androgen deficiency...
May 4, 2018: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/29726662/-value-of-the-serum-free-testosterone-level-in-detecting-erectile-dysfunction
#20
Zi-Bin Lin, Jun-Hong Deng, Liang-Liang Huang, Hua Shi, Jian-Ming Liu, Bin Ou-Yang, Jing-Xuan Xie
Objective: To investigate the values of serum calculated free testosterone (cFT), testosterone secretion index (TSI), and free testosterone index (FTI) in the diagnosis of ED with androgen deficiency by observing their changes in the patient. METHODS: We conducted this study among 185 men complaining of ED and 35 20-40 years old healthy males presenting at the clinic for premarital medical checkup. We asked them about their medical history, to fill in the International Index of Erectile Function (IIEF-5) Questionnaire, and to complete the nocturnal penile tumescence (NPT) test...
September 2017: Zhonghua Nan Ke Xue, National Journal of Andrology
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