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Testosterone deficiency

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https://www.readbyqxmd.com/read/29656047/the-complex-association-between-metabolic-syndrome-and-male-hypogonadism
#1
Christina Dimopoulou, Dimitrios G Goulis, Giovanni Corona, Mario Maggi
BACKGROUND: The complex association between metabolic syndrome (MetS) and male hypogonadism is well established. A number of observational studies show that low testosterone is associated with insulin resistance and an increased risk for diabetes mellitus and MetS in men. AIMS: To elucidate the association between MetS and male hypogonadism, present epidemiological data on the co-existence of the two comorbidities, enlighten the underlying pathophysiology and appraise the effects of testosterone supplementation therapy (TTh) and lifestyle modifications on MetS and body composition in men...
April 12, 2018: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/29651127/testosterone-deficiency-weakness-and-multimorbidity-in-men
#2
Mark D Peterson, Aleksandr Belakovskiy, Ryan McGrath, Joshua F Yarrow
The purposes of this study were to evaluate the association between total testosterone (TT) deficiency and weakness on multimorbidity in men. Analyses were performed to examine the prevalence of multimobidity among young, middle-aged, and older men, with and without testosterone deficiency. Multivariate logistic models were also used to determine the association between age-specific TT tertiles and multimorbidity, adjusting for key sociodemographic variables, as well as a secondary analysis adjusted for grip strength...
April 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29650456/-androgens-and-cardiovascular-risk-a-series-of-case-report-in-the-french-and-canadian-pharmacovigilance-databases
#3
M Rochoy, R Thomas, J Béné, D Deleplanque, M-C Vantyghem, S Gautier, D Deplanque
INTRODUCTION: Age-related androgenic deficiency (DALA) is a pathology that is increasingly cited in recent publications. The cardiovascular risk of testosterone is debated: present for the FDA, absent for the European Medicines Agency in 2015. Our objective was to analyze the association between androgens and vascular pathologies in adverse reactions reported in pharmacovigilance databases. MATERIAL AND METHOD: We conducted a retrospective case series study of the French and Canadian pharmacovigilance databases for the period 2005-2015...
April 9, 2018: Progrès en Urologie
https://www.readbyqxmd.com/read/29644167/chronic-scrotal-pain-may-lead-to-reduced-sexual-function-and-interest-while-sexual-activity-may-worsen-chronic-scrotal-pain-double-jeopardy
#4
Aosama Aljumaily, Hind Abdul Jaleel Al-Khazraji, Allan Gordon, Susan Lau, Keith Allen Jarvi
Background: While it is recognized that chronic pain may adversely impact sexual function and activity in men and we also recognize that sexual activity may worsen the pain for men with chronic scrotal pain (CSP), the effect on sexual functioning and conversely the impact of sex on CSP has not previously been documented. Methods: Retrospective analysis of a prospectively collected database. Results: From Feb 2014 to Sep 2015, a total of 128 men presenting for assessment of CSP completed all or parts of a standardized questionnaire...
March 2018: Translational Andrology and Urology
https://www.readbyqxmd.com/read/29623697/efficacy-and-safety-of-a-mixed-extract-of-trigonella-foenum-graecum-seed-and-lespedeza-cuneata-in-the-treatment-of-testosterone-deficiency-syndrome-a-randomized-double-blind-placebo-controlled-clinical-trial
#5
Hyun Jun Park, Kyeong Soo Lee, Eun Kyoung Lee, Nam Cheol Park
PURPOSE: The aim of this study was to investigate the efficacy and safety of a mixed extract of Trigonella foenum-graecum seed and Lespedeza cuneata (TFGL) for the treatment of testosterone deficiency syndrome (TDS). MATERIALS AND METHODS: Patients were instructed to take a placebo or 200 mg TFGL capsule twice per day for 8 weeks. The primary efficacy variable was the change from baseline in the Aging Males' Symptoms scale (AMS), as well as levels of serum total and free testosterone...
March 22, 2018: World Journal of Men's Health
https://www.readbyqxmd.com/read/29623694/which-exercise-is-better-for-increasing-serum-testosterone-levels-in-patients-with-erectile-dysfunction
#6
Jeong Kyun Yeo, Seung Ik Cho, Sun Gu Park, Seok Jo, Jeong Ku Ha, Jeong Woo Lee, Sung Yong Cho, Min Gu Park
PURPOSE: We investigated the correlations of serum total testosterone (TT) levels with body composition and physical fitness parameters in patients with erectile dysfunction (ED) to know the best exercise for testosterone deficiency. MATERIALS AND METHODS: Eighty-seven ED patients underwent serum TT assessment as well as body composition and basic exercise testing. The bioelectrical impedance analysis was used to assess body composition. Seven types of basic exercise tests were used to determine physical fitness...
January 26, 2018: World Journal of Men's Health
https://www.readbyqxmd.com/read/29619769/multiple-hormonal-and-metabolic-deficiency-syndrome-in-chronic-heart-failure-rationale-design-and-demographic-characteristics-of-the-t-o-s-ca-registry
#7
E Bossone, M Arcopinto, M Iacoviello, V Triggiani, F Cacciatore, C Maiello, G Limongelli, D Masarone, F Perticone, A Sciacqua, P Perrone-Filardi, A Mancini, M Volterrani, O Vriz, R Castello, A Passantino, M Campo, P A Modesti, A De Giorgi, I Monte, A Puzzo, A Ballotta, L Caliendo, R D'Assante, A M Marra, A Salzano, T Suzuki, A Cittadini
Recent evidence supports the concept that progression of chronic heart failure (CHF) depends upon an imbalance of catabolic forces over the anabolic drive. In this regard, multiple hormonal deficiency syndrome (MHDS) significantly has impacts upon CHF progression, and is associated with a worse clinical status and increased mortality. The T.O.S.CA. (Trattamento Ormonale nello Scompenso CArdiaco; Hormone Therapy in Heart Failure) Registry (clinicaltrial.gov = NCT02335801) tests the hypothesis that anabolic deficiencies reduce survival in a large population of mild-to-moderate CHF patients...
April 4, 2018: Internal and Emergency Medicine
https://www.readbyqxmd.com/read/29618492/autophagy-regulates-testosterone-synthesis-by-facilitating-cholesterol-uptake-in-leydig-cells
#8
Fengyi Gao, Guoping Li, Chao Liu, Hui Gao, Hao Wang, Weixiao Liu, Min Chen, Yongliang Shang, Lina Wang, Jian Shi, Wenlong Xia, Jianwei Jiao, Fei Gao, Jian Li, Liang Chen, Wei Li
Testosterone is indispensable for sexual development and maintaining male characteristics, and deficiency of this hormone results in primary or late-onset hypogonadism (LOH). Testosterone is primarily produced in Leydig cells, where autophagy has been reported to be extremely active. However, the functional role of autophagy in testosterone synthesis remains unknown. In this study, we show that steroidogenic cell-specific disruption of autophagy influenced the sexual behavior of aging male mice because of a reduction in serum testosterone, which is similar to the symptoms of LOH...
April 4, 2018: Journal of Cell Biology
https://www.readbyqxmd.com/read/29615651/low-testosterone-in-apoe-ldl-receptor-double-knockout-mice-is-associated-with-rarefied-testicular-capillaries-together-with-fewer-and-smaller-leydig-cells
#9
Kai Steinfeld, Daniela Beyer, Christian Mühlfeld, Andrea Mietens, Gerrit Eichner, Bora Altinkilic, Marian Kampschulte, Qingkui Jiang, Gabriele A Krombach, Thomas Linn, Wolfgang Weidner, Ralf Middendorff
The testis as a site for atherosclerotic changes has so far attracted little attention. We used the apolipoprotein E (ApoE)/low density lipoprotein (LDL) receptor deficient mouse model (KO) for atherosclerosis (20, 40, 60 and 87-week-old) to investigate whether Leydig cells or the capillary network are responsible for reduced serum testosterone levels previously observed in extreme ages of this model. In KO mice, overall testosterone levels were reduced whereas the adrenal gland-specific corticosterone was increased excluding a general defect of steroid hormone production...
April 3, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29609858/undetectable-high-density-lipoprotein-cholesterol-in-acute-malaria
#10
Ana Rakovac Tisdall, Vivion Edward Francis Crowley, Martin Andrew Crook
We report the case of a 39-year-old West African man in whom high-density lipoprotein cholesterol (HDL-C) was identified as undetectable at <0.08 mmol/L. Total cholesterol in the same sample was 2.85 mmol/L; triglycerides were only mildly elevated at 2.32 mmol/L. He was admitted with a 2-week history of polydipsia, polyuria, weight loss and hyperpyrexia. Dual malarial infection with Plasmodium ovale and falciparum was identified and attributed to a recent trip to Nigeria without chemoprophylaxis. Also, he was diagnosed with diabetes mellitus with random hyperglycemia of 39 mmol/L but no ketonemia...
March 9, 2018: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/29606625/s-nitrosoglutathione-reductase-gsnor-deficiency-results-in-secondary-hypogonadism
#11
Thomas A Masterson, Himanshu Arora, Shathiyah Kulandavelu, Rona S Carroll, Ursula B Kaiser, Sakir H Gultekin, Joshua M Hare, Ranjith Ramasamy
BACKGROUND: Excess reactive oxygen species and reactive nitrogen species are implicated in male infertility and impaired spermatogenesis. AIM: To investigate the effect of excess reactive nitrogen species and nitrosative stress on testicular function and the hypothalamic-pituitary-gonadal axis using the S-nitrosoglutathione reductase-null (Gsnor-/- ) mouse model. METHODS: Testis size, pup number, and epididymal sperm concentration and motility of Gsnor-/- mice were compared with those of age-matched wild-type (WT) mice...
March 29, 2018: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/29606031/testicular-developmental-impairment-caused-by-flutamide-induced-and-dehp-induced-cryptorchid-rat-models-is-mediated-by-excessive-apoptosis-and-deficient-autophagy
#12
Yi Wei, Yu Zhou, Xiang-Liang Tang, Bin Liu, Lian-Ju Shen, Chun-Lan Long, Tao Lin, Da-Wei He, Sheng-de Wu, Guang-Hui Wei
BACKGROUND: Cryptorchidism is a common condition of childhood, and it is known to impair fertility potential. However, the underlying mechanisms remain unclear. METHODS: This study constructed two cryptorchid rat models to investigate the roles of apoptosis and autophagy in testicular impairment induced by cryptorchidism. Pregnant rats were randomly divided into three groups. Group I: non-treated rats were used as controls. Group II: injected with drug Flutamide (Flu) 25 mg/kg/bw/d from Gestation Day (GD) 11-19...
April 2, 2018: Toxicology Mechanisms and Methods
https://www.readbyqxmd.com/read/29601923/evaluation-and-management-of-testosterone-deficiency-aua-guideline
#13
John P Mulhall, Landon W Trost, Robert E Brannigan, Emily G Kurtz, J Bruce Redmon, Kelly A Chiles, Deborah J Lightner, Martin M Miner, M Hassan Murad, Christian J Nelson, Elizabeth A Platz, Lakshmi V Ramanathan, Ronald W Lewis
PURPOSE: There has been a marked increase in testosterone prescriptions in the past decade resulting in a growing need to give practicing clinicians proper guidance on the evaluation and management of the testosterone deficient patient. MATERIALS & METHODS: A systematic review utilized research from the Mayo Clinic Evidence Based Practice Center and additional supplementation by the authors. Evidence-based statements were based on body of evidence strength Grade A, B, or C and were designated as Strong, Moderate, and Conditional Recommendations with additional statements presented in the form of Clinical Principles or Expert Opinions...
March 27, 2018: Journal of Urology
https://www.readbyqxmd.com/read/29600542/a-new-2-testosterone-gel-formulation-a-comparison-with-currently-available-topical-preparations
#14
REVIEW
S Arver, C Stief, J de la Rosette, T H Jones, A Neijber, D Carrara
Testosterone gel formulations have become a popular testosterone replacement therapy in patients with hypogonadism since their advent in the year 2000. The gel formulations restore testosterone levels to mid-normal physiological levels (14-17.5 nmol/L) as early as within 24 h, and help alleviate the signs and symptoms of testosterone deficiency, thereby leading to an improved quality of life. Although testosterone gels have a favourable efficacy and safety profile as compared to injectable and patch formulations, risk of secondary exposure poses a challenge...
March 30, 2018: Andrology
https://www.readbyqxmd.com/read/29584617/constitutively-active-follicle-stimulating-hormone-receptor-enables-androgen-independent-spermatogenesis
#15
Olayiwola O Oduwole, Hellevi Peltoketo, Ariel Poliandri, Laura Vengadabady, Marcin Chrusciel, Milena Doroszko, Luna Samanta, Laura Owen, Brian Keevil, Nafis A Rahman, Ilpo T Huhtaniemi
Spermatogenesis is regulated by the 2 pituitary gonadotropins, luteinizing hormone (LH) and follicle-stimulating hormone (FSH). This process is considered impossible without the absolute requirement of LH-stimulated testicular testosterone (T) production. The role of FSH remains unclear because men and mice with inactivating FSH receptor (FSHR) mutations are fertile. We revisited the role of FSH in spermatogenesis using transgenic mice expressing a constitutively strongly active FSHR mutant in a LH receptor-null (LHR-null) background...
March 26, 2018: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29570451/evaluating-of-%C3%AE-carotene-role-in-ameliorating-of-favism-induced-disturbances-in-blood-and-testis
#16
Khaled M M Koriem, Mahmoud S Arbid
Background Favism is an acute hemolytic anemia occurs in glucose 6-phosphate dehydrogenase (G6-PD) deficient individuals. β-Carotene occurs in vegetables such as carrots. This study aimed to establish the therapeutic effect of β-carotene to rebalance the testicular and blood proteins disturbances in favism. Methods Forty-eight male rats were divided into six equal groups; Groups 1, 2 and 3: normal rats were daily oral administrated with 1 ml saline, 1 ml corn oil and β-carotene (60 mg/kg dissolved in 1 ml corn oil), respectively, once a day over 15 days period...
March 23, 2018: Journal of Complementary & Integrative Medicine
https://www.readbyqxmd.com/read/29562364/testosterone-therapy-in-men-with-hypogonadism-an-endocrine-society-clinical-practice-guideline
#17
Shalender Bhasin, Juan P Brito, Glenn R Cunningham, Frances J Hayes, Howard N Hodis, Alvin M Matsumoto, Peter J Snyder, Ronald S Swerdloff, Frederick C Wu, Maria A Yialamas
Objective: To update the "Testosterone Therapy in Men With Androgen Deficiency Syndromes" guideline published in 2010. Participants: The participants include an Endocrine Society-appointed task force of 10 medical content experts and a clinical practice guideline methodologist. Evidence: This evidence-based guideline was developed using the Grading of Recommendations, Assessment, Development, and Evaluation approach to describe the strength of recommendations and the quality of evidence...
March 17, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29560610/investigating-the-effect-of-testosterone-by-itself-and-in-combination-with-letrozole-on-1-25-dihydroxy-vitamin-d-and-fgf23-in-male-rats
#18
F Saki, S R Kasaee, F Sadeghian, F Koohpeyma, G H R Omrani
BACKGROUND: Testosterone deficiency might be associated with vitamin D levels in hypogonadal men, but it is not clear whether testosterone can affect vitamin D and fibroblast growth factor-23 (FGF23), either directly or indirectly via aromatization to estradiol. We aimed to investigate the role of testosterone on vitamin D metabolism and serum FGF23 in male rats. METHODS: A total of 48 male rats were divided into 4 equal groups: sham; O, orchiectomy; O + T, orchiectomized rats treated with testosterone; and O + T + L, orchiectomized rats treated with combination of testosterone and letrozole...
March 20, 2018: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/29559852/-bmi1-deficient-mice-exhibit-male-infertility
#19
Xiuliang Dai, Qian Zhang, Zhenzhen Yu, Weiwei Sun, Rong Wang, Dengshun Miao
Previous studies have demonstrated that the polycomb repressor Bmi1 is universally expressed in all types of testicular cells and might regulate the spermatogonia proliferation, however, it is unclear whether Bmi1 plays a critical role in maintaining normal male fertility in vivo. To answer this question, we first confirmed that Bmi1 is universally expressed in all types of testicular cells and found that the gene relative expression levels of Bmi1 in testis were the highest relative to other organs. Then we investigated the role of Bmi1 in maintaining normal male fertility using Bmi1 knockout male mouse model...
2018: International Journal of Biological Sciences
https://www.readbyqxmd.com/read/29553041/aromatase-deficiency-due-to-a-novel-mutation-in-cyp19a1-gene
#20
Edip Ünal, Ruken Yıldırım, Funda Feryal Taş, Vasfiye Demir, Hüseyin Onay, Yusuf Kenan Haspolat
BACKGROUND: Aromatase deficiency is a rare autosomal recessive genetic disorder with an unknown incidence. Aromatase converts androgens into estrogen in the gonadal and extra-gonadal tissues. Aromatase deficiency causes ambiguous genitalia in the female fetus and maternal virilization (hirsutism, acne, cliteromegaly, deep voice) during the pregnancy due to increased concentration of androgens. METHODS AND RESULTS: The-nineteen-month-old girl was assessed due to ambiguous genitalia There were findings of maternal virilization during pregnancy...
March 19, 2018: Journal of Clinical Research in Pediatric Endocrinology
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