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Testosterone deficiency

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https://www.readbyqxmd.com/read/28429281/impact-of-thyroid-disease-on-testicular-function
#1
REVIEW
Sandro La Vignera, Roberto Vita, Rosita A Condorelli, Laura M Mongioì, Silvia Presti, Salvatore Benvenga, Aldo E Calogero
INTRODUCTION: Testis was considered unresponsive to thyroid hormone for a long time. However, like in animals, the presence of thyroid hormone receptors in different testicular cell types was demonstrated also in humans. Accordingly, thyrotoxicosis and hypothyroidism have remarkable effects on testicular function and more extensively on fertility. REVIEW: Thyrotoxicosis and hypothyroidism are associated with changes affecting the endocrine, sexual, or reproductive functions...
April 20, 2017: Endocrine
https://www.readbyqxmd.com/read/28416169/pathologic-fracture-of-the-thoracic-spine-in-a-male-master-ultra-marathoner-due-to-the-combination-of-a-vertebral-hemangioma-and-osteopenia
#2
Beat Knechtle, Pantelis T Nikolaidis, Bruno Lutz, Thomas Rosemann, Christian B Baerlocher
Vertebral hemangiomas are the most common benign vertebral neoplasms and are generally asymptomatic. In the present study, we report the case of a 52-year-old male master ultra-marathoner suffering from a pathologic fracture of the thoracic spine due to a vertebral hemangioma. A further examination in the athlete revealed an accompanying osteopenia, which was most likely due to a deficiency in both vitamin D and testosterone. The treatment of the fracture consisted of percutaneous vertebroplasty. Shortly after the operation the athlete was able to continue running...
March 27, 2017: Medicina
https://www.readbyqxmd.com/read/28408926/male-hypogonadism-and-osteoporosis-the-effects-clinical-consequences-and-treatment-of-testosterone-deficiency-in-bone-health
#3
REVIEW
Gary Golds, Devon Houdek, Terra Arnason
It is well recognized that bone loss accelerates in hypogonadal states, with female menopause being the classic example of sex hormones affecting the regulation of bone metabolism. Underrepresented is our knowledge of the clinical and metabolic consequences of overt male hypogonadism, as well as the more subtle age-related decline in testosterone on bone quality. While menopause and estrogen deficiency are well-known risk factors for osteoporosis in women, the effects of age-related testosterone decline in men on bone health are less well known...
2017: International Journal of Endocrinology
https://www.readbyqxmd.com/read/28392474/novel-fsh%C3%AE-mutation-in-a-male-patient-with-isolated-fsh-deficiency-and-infertility
#4
Junjie Zheng, Jangfeng Mao, Mingxuan Cui, Zhaoxiang Liu, Xi Wang, Shuyu Xiong, Min Nie, Xueyan Wu
Isolated follicle stimulating hormone (FSH) deficiency due to mutations in FSHβ is an extremely rare autosomal recessive disease that has only been reported in ten patients to date. Symptoms of the disease include amenorrhoea and hypogonadism in women and azoospermia and normal testosterone levels in men. This study describes a Chinese male patient who presented with cryptorchidism and infertility. His serum hormonal profile revealed low FSH, elevated LH and normal testosterone levels. Sequence analysis identified a novel homozygous mutation in the FSHβ gene (c...
April 6, 2017: European Journal of Medical Genetics
https://www.readbyqxmd.com/read/28389909/dynamics-of-hormonal-disorders-following-unilateral-orchiectomy-for-a-testicular-tumor
#5
Paweł J Wiechno, Maria Kowalska, Jakub Kucharz, Małgorzata Sadowska, Wojciech Michalski, Grażyna Poniatowska, Joanna Jońska-Gmyrek, Joanna Rzymkowska, Karol Nietupski, Tomasz Demkow
Testicular tumors and their treatment interfere with homeostasis, hormonal status included. The aim of the study was to evaluate hormonal disorders of the pituitary-gonadal axis in men treated for testicular tumors. One hundred twenty-eight men treated for a unilateral testicular tumor at our institution were included. The hormonal status was prospectively evaluated in 62 patients before orchiectomy, 120 patients 1 month after orchiectomy and 110 patients at least 1 year after the treatment. The concentrations of human chorionic gonadotropin (hCG), testosterone (T), estradiol, luteinizing hormone (LH), follicle-stimulating hormone (FSH) and prolactin were measured...
May 2017: Medical Oncology
https://www.readbyqxmd.com/read/28386370/modifications-of-anxiety-like-behavior-in-prenatally-stressed-male-offspring-with-imbalance-of-androgens
#6
Julia Fedotova, Viktoria Akulova, Svetlana Pivina, Jozef Dragasek, Martin Caprnda, Peter Kruzliak
Gonadal hormones have been well-known to affect brain regions known to be involved in the modulation of mood and affective-related behavior. Prenatal stress might alter hypothalamic-pituitary-gonadal axis, it could be a target for development of affective-related disorders in male offspring. The present study was designed to examine an anxiety-like behavior in the adult male offspring with low levels of endogenous androgens delivered from pregnant dams exposed to prenatal stress from gestation day 15 to gestation day 19...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/28386349/pyrroloquinoline-quinone-prevents-testosterone-deficiency-induced-osteoporosis-by-stimulating-osteoblastic-bone-formation-and-inhibiting-osteoclastic-bone-resorption
#7
Xuan Wu, Jie Li, Hengwei Zhang, Hui Wang, Guoyong Yin, Dengshun Miao
Accumulating evidences suggest that oxidative stress caused and deteriorated the aging related osteoporosis and pyrroloquinoline quinone (PQQ) is a powerful antioxidant. However, it is unclear whether PQQ can prevent testosterone deficiency-induced osteoporosis. In this study, the orchidectomized (ORX) mice were supplemented in diet with/without PQQ for 48 weeks, and compared with each other and with sham mice. Results showed that bone mineral density, trabecular bone volume, collagen deposition and osteoblast number were decreased significantly in ORX mice compared with shame mice, whereas PQQ supplementation largely prevented these alterations...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/28382688/epimedii-herba-a-promising-herbal-medicine-for-neuroplasticity
#8
REVIEW
Jae-Heung Cho, Jae-Young Jung, Beom-Joon Lee, Kyungjin Lee, Jae-Woo Park, Youngmin Bu
Epimedii Herba (EH) is an herbal medicine originating from several plants of the genus Epimedium. It is a major therapeutic option for kidney yang deficiency syndrome, which is closely related to androgen hormones and also has been used to treat hemiplegia following a stroke in traditional medicine of Korea and PR China. To date, many clinical and basic researches of EH have shown the activities on functional recovery from brain diseases. Recently, neuroplasticity, which is the spontaneous reaction of the brain in response to diseases, has been shown to accelerate functional recovery...
April 6, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/28379671/ten-cases-with-46-xx-testicular-disorder-of-sex-development-single-center-experience
#9
Emre Can Akinsal, Numan Baydilli, Abdullah Demirtas, Cetin Saatci, Oguz Ekmekcioglu
OBJECTIVE: To present clinical, chromosomal and hormonal features of ten cases with SRY-positive 46,XX testicular disorder of sex development who were admitted to our infertility clinic. CASES AND METHODS: Records of the cases who were admitted to our infertility clinic between 2004 and 2015 were investigated. Ten 46,XX testicular disorder of sex development cases were detected. Clinical, hormonal and chromosomal assessments were analized. RESULTS: Mean age at diagnosis was 30...
April 6, 2017: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/28379662/the-prostate-after-castration-and-hormone-replacement-in-a-rat-model-structural-and-ultrastructural-analysis
#10
Bruno Felix-Patrício, Alexandre F Miranda, Jorge L Medeiros, Carla B M Gallo, Bianca M Gregório, Diogo B Souza, Waldemar S Costa, Francisco J B Sampaio
PURPOSE: To evaluate if late hormonal replacement is able to recover the prostatic tissue modified by androgenic deprivation. MATERIALS AND METHODS: 24 rats were assigned into a Sham group; an androgen deficient group, submitted to bilateral orchiectomy (Orch); and a group submitted to bilateral orchiectomy followed by testosterone replacement therapy (Orch+T). After 60 days from surgery blood was collected for determination of testosterone levels and the ventral prostate was collected for quantitative and qualitative microscopic analysis...
April 6, 2017: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/28376482/discordant-genotypic-sex-and-phenotype-variations-in-two-spanish-siblings-with-17%C3%AE-hydroxylase-17-20-lyase-deficiency-carrying-the-most-prevalent-mutated-cyp17a1-alleles-of-brazilian-patients
#11
Mónica Fernández-Cancio, Emilio García-García, Carmen González-Cejudo, María-Angeles Martínez-Maestre, Miguel-Angel Mangas-Cruz, Gil Guerra-Junior, Maricilda Pandi de Mello, Ivo J P Arnhold, Mirian Y Nishi, Berenice Bilharinho Mendonça, Elena García-Arumí, Laura Audí, Eduardo Tizzano, Antonio Carrascosa
17α-hydroxylase/17,20-lyase deficiency is a rare form of congenital adrenal hyperplasia caused by mutations in CYP17A1. Two phenotypic female sisters, aged 17 and 15 years and with 46,XY and 46,XX karyotypes, respectively, presented with primary amenorrhea and absent secondary sexual characteristics. The elder sib also presented with high blood pressure. Both patients had elevated levels of ACTH, gonadotropins, progesterone, corticosterone, and deoxycorticosterone, and reduced levels of estradiol, testosterone, androstenedione, 17-OH-P, DHEA-S, cortisol, aldosterone, and renin activity...
April 4, 2017: Sexual Development: Genetics, Molecular Biology, Evolution, Endocrinology, Embryology, and Pathology of Sex Determination and Differentiation
https://www.readbyqxmd.com/read/28368486/pulsatile-gnrh-therapy-may-restore-hypothalamus-pituitary-testis-axis-function-in-patients-with-congenital-combined-pituitary-hormone-deficiency-a-prospective-self-controlled-trial
#12
Junjie Zheng, Jangfeng Mao, Hongli Xu, Xi Wang, Bingkun Huang, Zhaoxiang Liu, Mingxuan Cui, Shuyu Xiong, Wanlu Ma, Le Min, Ursula B Kaiser, Min Nie, Xueyan Wu
Context: The effectiveness of pulsatile gonadotropin-releasing hormone (GnRH) therapy in congenital combined pituitary hormone deficiency (CCPHD) patients has not been investigated due to the limited number of patients as well as these patients' presumed pituitary hypoplasia, poor gonadotrophic cell reserve, and impaired gonadotrophic response to GnRH. Objective: To assess the pituitary response to pulsatile GnRH therapy in men with CCPHD. Design: A prospective, self-controlled, 3 months clinical trial...
March 27, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28366446/visceral-adipose-tissue-and-leptin-hyperproduction-are-associated-with-hypogonadism-in-men-with-chronic-kidney-disease
#13
Gabriela Cobo, Antonio C Cordeiro, Fernanda Cassulo Amparo, Celso Amodeo, Bengt Lindholm, Juan Jesús Carrero
OBJECTIVE: Hypogonadism is a common endocrine disorder in men with chronic kidney disease (CKD), but its pathophysiology is poorly understood. We here explore the plausible contribution of abdominal adiposity and leptin hyperproduction to testosterone deficiency in this patient population. DESIGN: Cross-sectional analysis with all men included the Malnutrition, Inflammation and Vascular Calcification cohort, which enrolled consecutive nondialyzed patients with CKD stages 3-5...
March 31, 2017: Journal of Renal Nutrition
https://www.readbyqxmd.com/read/28361416/characteristics-of-depressive-like-behavior-of-prenatally-stressed-male-rats-with-androgen-deficiency
#14
Yu O Fedotova, V K Akulova, S G Pivina
Characteristics of depressive-like behavior of male rats with androgen deficiency born by mothers subjected to prenatal stress during pregnancy were assessed by using Porsolt tests and open-field tests. The level of depression-like behavior in prenatally stressed males increased more intensively than in non-stressed gonadectomized males. Chronic administration of testosterone propionate (0.5 mg/kg, intramuscularly, for 14 days) increased depressive behavior in prenatally stressed gonadectomized males in contrast to its antidepressant effect in nonstressed gonadectomized rats...
March 30, 2017: Bulletin of Experimental Biology and Medicine
https://www.readbyqxmd.com/read/28359097/a-perspective-on-middle-aged-and-older-men-with-functional-hypogonadism-focus-on-holistic-management
#15
Mathis Grossmann, Alvin M Matsumoto
Context: Middle-aged and older men (≥50 years), especially those who are obese and suffer from comorbidities, not uncommonly present with clinical features consistent with androgen deficiency and modestly reduced testosterone levels. Commonly, such men do not demonstrate anatomical hypothalamic-pituitary-testicular axis pathology but have functional hypogonadism that is potentially reversible. Evidence Acquisition: Literature review from 1970 to October 2016. Evidence Synthesis: Although definitive randomized controlled trials are lacking, evidence suggests that in such men, lifestyle measures to achieve weight loss and optimization of comorbidities, including discontinuation of offending medications, lead to clinical improvement and a modest increase in testosterone...
March 1, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28352619/low-levels-of-serum-testosterone-in-middle-aged-men-impact-pathological-features-of-prostate-cancer
#16
Elton Llukani, Benjamin F Katz, Ilir Agalliu, Andrew Lightfoot, Sue-Jean S Yu, Martin Kathrins, Ziho Lee, Yu-Kai Su, Kelly Monahan Agnew, Alice McGill, Daniel D Eun, David I Lee
BACKGROUND: Serum testosterone deficiency increases with aging. Age is also a major risk factor for prostate cancer (PrCa) and PCa tumors are more frequently diagnosed among men >65 years old. We evaluated the relationship between preoperative serum testosterone and clinical/ pathological features of PrCa in middle-aged and elderly patients. METHODS: A total of 605 PrCa patients who underwent robotic-assisted radical prostatectomy between September 2010 and January 2013 at the University of Pennsylvania, and who had serum testosterone levels measured using Elecsys Testosterone II Immunoassay were included in this IRB-approved protocol...
March 2017: Prostate International
https://www.readbyqxmd.com/read/28351832/gonad-related-factors-promote-muscle-performance-gain-during-postnatal-development-in-male-and-female-mice
#17
Vanessa Ueberschlag-Pitiot, Amalia Stantzou, Julien Messéant, Megane Lemaitre, Daniel J Owens, Philippe Noirez, Pauline Roy, Onnik Agbulut, Daniel Metzger, Arnaud Ferry
In order to better define the role of male and female gonad-related factors (MGRF, presumably testosterone, and FGRF, presumably estradiol, respectively) on mouse hindlimb skeletal muscle contractile performance/function gain during postnatal development, we analysed the effect of castration initiated before puberty in male and female mice. We found that muscle absolute and specific (normalized to muscle weight) maximal forces were decreased in 6-month old male and female castrated mice, as compared to age- and sex-matched intact mice, without alteration in neuromuscular transmission...
March 28, 2017: American Journal of Physiology. Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28343791/androgen-receptor-deficient-islet-%C3%AE-cells-exhibit-alteration-in-genetic-markers-of-insulin-secretion-and-inflammation-a-transcriptome-analysis-in-the-male-mouse
#18
Weiwei Xu, Tianhua Niu, Beibei Xu, Guadalupe Navarro, Matthew J Schipma, Franck Mauvais-Jarvis
AIMS: Testosterone action is mediated via the androgen receptor (AR). We have reported that male mice lacking AR selectively in β-cells (βARKO(-/y)) develop decreased glucose-stimulated insulin secretion (GSIS), producing glucose intolerance. We showed that testosterone action on AR in β-cells amplifies the insulinotropic action of GLP-1 on its receptor via a cAMP-dependent protein kinase-A pathway. METHODS: To investigate AR-dependent gene networks in β-cells, we performed a high throughput whole transcriptome sequencing (RNA-Seq) in islets from male βARKO(-/y) and control mice...
March 9, 2017: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/28341581/the-graham-jackson-memorial-lecture-issm-2016-the-man-who-knew-too-much-time-to-recognize-erectile-dysfunction-and-low-testosterone-as-independent-risk-factors-for-cardiovascular-disease
#19
REVIEW
Geoffrey Hackett
INTRODUCTION: Graham Jackson introduced the concept that erectile dysfunction (ED) is a marker for undiagnosed cardiovascular (CV) disease and future events. In the Princeton 3 guidelines, he recognized the important impact of testosterone deficiency (TD) on all-cause and CV mortality. Recent evidence suggests that testosterone therapy to target levels and for sufficient duration decreases CV events. Unfortunately, this had a modest impact on CV disease management because ED is not incorporated into current risk calculators...
March 21, 2017: Sexual Medicine Reviews
https://www.readbyqxmd.com/read/28323036/targeting-androgen-receptor-versus-targeting-androgens-to-suppress-castration-resistant-prostate-cancer
#20
Changcheng Guo, Shuyuan Yeh, Yuanjie Niu, Gonghui Li, Junhua Zheng, Lei Li, Chawnshang Chang
Prostate cancer (PCa) is the 2nd leading cause of cancer-related death among men in the United States and its progression is tightly associated with the androgen/androgen receptor (AR) signals. Men castrated before puberty (eunuchs) or men with inherited deficiency of type II 5α-reductase (with failure to convert testosterone to the more potent dihydrotestosterone) (DHT) do not develop PCa. To date, androgen deprivation therapy (ADT) with anti-androgen treatments to reduce or prevent androgens from binding to the AR remains the main therapeutic option for advanced PCa since its discovery by Huggins and Hodges in 1941...
March 18, 2017: Cancer Letters
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