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Neijssen dendritic gap

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https://www.readbyqxmd.com/read/19553546/direct-antigen-presentation-and-gap-junction-mediated-cross-presentation-during-apoptosis
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Baoxu Pang, Joost Neijssen, Xiaohang Qiao, Lennert Janssen, Hans Janssen, Christoph Lippuner, Jacques Neefjes
MHC class I molecules present peptides from endogenous proteins. Ags can also be presented when derived from extracellular sources in the form of apoptotic bodies. Cross-presentation of such Ags by dendritic cells is required for proper CTL responses. The fate of Ags in cells initiated for apoptosis is unclear as is the mechanism of apoptosis-derived Ag transfer into dendritic cells. Here we show that novel Ags can be generated by caspases and be presented by MHC class I molecules of apoptotic cells. Since gap junctions function until apoptotic cells remodel to form apoptotic bodies, transfer and cross-presentation of apoptotic peptides by neighboring and dendritic cells occurs...
July 15, 2009: Journal of Immunology: Official Journal of the American Association of Immunologists
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