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https://www.readbyqxmd.com/read/30295521/comparison-of-molecular-diagnosis-with-serum-markers-and-synovial-fluid-analysis-in-patients-with-prosthetic-joint-infection
#1
COMPARATIVE STUDY
F-C Kuo, Y-D Lu, C-T Wu, H-L You, G-B Lee, M S Lee
AIMS: The aim of this study was to compare the results of 16S/28S rRNA sequencing with the erythrocyte sedimentation rate (ESR), C-reactive protein (CRP) level, and synovial fluid analysis in the diagnosis of prosthetic joint infection (PJI). PATIENTS AND METHODS: Between September 2015 and August 2016, 214 consecutive patients were enrolled. In the study population, there were 25 patients with a PJI and 189 controls. Of the PJI patients, 14 (56%) were women, and the mean age at the time of diagnosis was 65 years (38 to 83)...
October 2018: Bone & Joint Journal
https://www.readbyqxmd.com/read/30182141/significant-increase-of-pathogen-detection-rate-by-dry-arthroscopic-biopsies-at-suspected-low-grade-infection-following-total-knee-arthroplasty-a-prospective-observational-study
#2
Sebastian F Baumbach, Wolf C Prall, Andreas M Scharpf, Viktoria Hererich, Maximilian Schmidt, Norbert P Suedkamp, Amelie Stoehr, Hermann O Mayr
INTRODUCTION: The differentiation between stiff-knee and low-grade periprosthetic joint infection (PJI) is the current diagnostic challenge in total knee (TKA) revision arthroplasty. The aim of this study was to investigate the additional value of dry biopsies, compared to wet biopsies, in patients presenting with knee stiffness following primary TKA. MATERIALS AND METHODS: Single center, prospective observational study. Consecutive patients with joint stiffness of unknown origin following primary TKA were enrolled...
September 4, 2018: Archives of Orthopaedic and Trauma Surgery
https://www.readbyqxmd.com/read/29961076/selection-and-investigation-of-a-primate-model-of-spontaneous-degenerative-knee-osteoarthritis-the-cynomolgus-monkey-macaca-fascicularis
#3
Gang Liu, Lei Zhang, Xin Zhou, Bao L Zhang, Guang X Guo, Ping Xu, Guo Y Wang, Shi J Fu
BACKGROUND The aim of this study was to identify a primate model of degenerative knee osteoarthritis (KOA) that may be more relevant for research studies on degenerative KOA in humans. MATERIAL AND METHODS Sixteen specific-pathogen-free (SPF) male cynomolgus monkeys (Macaca fascicularis) were divided into group A (n=8), an old group (22.0-25.3 years of age), and group B (n=8), a young group (3.0-5.2 years of age). For each primate, the behavior was observed, knee circumference was measured, knee joint X-rays were performed, and peripheral blood white blood cell (WBC) counts were measured, and the Kellgren and Lawrence (K-L) system was used for the classification of osteoarthritis...
July 1, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29916927/laboratory-tests-for-diagnosis-of-chronic-periprosthetic-joint-infection-can-help-predict-outcomes-of-two-stage-exchange
#4
Maureen K Dwyer, Christopher Damsgaard, Jason Wadibia, Gordon Wong, Damien Lazar, Eric Smith, Carl Talmo, Hany Bedair
BACKGROUND: Although 2-stage exchange arthroplasty is the most effective treatment among available strategies for managing chronic periprosthetic joint infection (PJI), rates of its success vary greatly. The purpose of our study was to examine whether objective measurements collected at the time of the diagnosis of PJI could be used to identify patients at risk of failure of 2-stage exchange. METHODS: We identified 205 patients across 4 institutions who underwent 2-stage exchange arthroplasty for the treatment of PJI following total hip or total knee arthroplasty...
June 20, 2018: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/29789519/a-macaca-fascicularis-knee-osteoarthritis-model-developed-by-modified-hulth-combined-with-joint-scratches
#5
Xin Zhou, Lei Zhang, Xiaoguang Guo, Gang Liu, Guoyou Wang, Shijie Fu
BACKGROUND Osteoarthritis is a common degenerative disease of joints, and animal models have important significance in the investigation of this disease. The aim of this study was to develop a better method for developing osteoarthritis models in primates by comparing the modified Hulth score combined with joint scratches modeling method with others. MATERIAL AND METHODS We randomly divided 15 young male Macaca fascicularis and 3 old male Macaca fascicularis into 6 groups (n=3). Knee osteoarthritis (KOA) models were developed with different methods: modified Hulth combined with joint scratches (Group A), modified Hulth (Group B), Hulth (Group C), spontaneous models (Group D); sham-operated (Group E), and blank control (Group F)...
May 23, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29669751/hip-synovial-fluid-cell-counts-in-children-from-a-lyme-disease-endemic-area
#6
Arianna H Dart, Kenneth A Michelson, Paul L Aronson, Aris C Garro, Thomas J Lee, Kimberly M Glerum, Peter A Nigrovic, Mininder S Kocher, Richard G Bachur, Lise E Nigrovic
BACKGROUND: Patients with septic hip arthritis require surgical drainage, but they can be difficult to distinguish from patients with Lyme arthritis. The ability of synovial fluid white blood cell (WBC) counts to help discriminate between septic and Lyme arthritis of the hip has not been investigated. METHODS: We assembled a retrospective cohort of patients ≤21 years of age with hip monoarticular arthritis and a synovial fluid culture obtained who presented to 1 of 3 emergency departments located in Lyme disease endemic areas...
May 2018: Pediatrics
https://www.readbyqxmd.com/read/29656969/the-leukocyte-esterase-test-strip-is-a-poor-rule-out-test-for-periprosthetic-joint-infection
#7
Carl A Deirmengian, Lihua Liang, John P Rosenberger, Tony R Joaquim, Martin R Gould, Patrick A Citrano, Keith W Kardos
BACKGROUND: The urinary leukocyte esterase (LE) test strip has been suggested as a good screening test for periprosthetic joint infection (PJI). The purpose of this study is to compare the diagnostic profile of LE assays from different manufacturers and determine whether the LE test strip is a good rule-out test. METHODS: Synovial fluid samples (N = 344), sent to 1 laboratory for PJI testing, were used in this prospective study. Four different tests for synovial fluid LE were simultaneously evaluated for their performance in detecting white blood cell (WBC) positive samples (>3000 cells/µL)...
August 2018: Journal of Arthroplasty
https://www.readbyqxmd.com/read/29243060/synovial-aspiration-and-serological-testing-in-two-stage-revision-arthroplasty-for-prosthetic-joint-infection-evaluation-before-reconstruction-with-a-mean-follow-up-of-twenty-seven-months
#8
Heinrich M L Mühlhofer, C Knebel, Florian Pohlig, Susanne Feihl, Norbert Harrasser, Johannes Schauwecker, Rüdiger von Eisenhart-Rothe
INTRODUCTION: The two-stage revision protocol is the gold standard for controlling and treating low-grade prosthetic joint infections of total hip and total knee arthroplasty. The antibiotic pause for diagnostic reasons before reconstruction (stage two) is discussed in relation to the persistence of the infection and the development of resistant bacterial strains. Serological markers and a synovial analysis are commonly used to exclude the persistence of infection. Therefore, we asked (1) is the serological testing of C-reactive protein and leucocytes a valuable tool to predict a persistence of infection? and (2) what is the role of synovial aspiration of Plymethylmethacrylat (PMMA) spacers in hip and knee joints? MATERIALS AND METHODS: One hundred twelve patients who were MSIS criteria-positive for a prosthetic joint infection were studied, including 45 total hip arthroplasties (THA) and 67 total knee artrhoplasties (TKA) patients...
February 2018: International Orthopaedics
https://www.readbyqxmd.com/read/28834596/evaluation-of-biological-fluid-analysis-using-the-sysmex-xn-automatic-hematology-analyzer
#9
Vicente Aguadero, Ruth Cano-Corres, Eugenio Berlanga, Montserrat Torra
BACKGROUND: Hematological cytometers with a biological fluid module could potentially correct the limitations of the manual chamber method. This study evaluates the agreement between the manual technique and the Sysmex XN-1000 analyzer for white blood cell (WBC) and red blood cell (RBC) counts, as well as for leukocyte differentiation in different types of fluids. This study also evaluates the advantages of incorporating the technique in routine laboratory work. METHODS: One hundred and three fluid samples examined were 45 ascite (AF), 21 synovial (SF), 33 pleural (PF), and 31 cerebrospinal (CSF) fluid samples...
August 23, 2017: Cytometry. Part B, Clinical Cytometry
https://www.readbyqxmd.com/read/28712799/diagnosing-periprosthetic-joint-infection-and-the-winner-is
#10
COMPARATIVE STUDY
Alisina Shahi, Timothy L Tan, Michael M Kheir, Dean D Tan, Javad Parvizi
BACKGROUND: Diagnosis of periprosthetic joint infection (PJI) remains a challenge despite a wide variety of available diagnostic tests. The question that arises is which of these tests has a better performance for diagnosing PJI. Diagnostic odds ratio (DOR) has been described as the best indicator for test performance. METHODS: To compare the performance of the standard diagnostic tests, the DOR of serum erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP), synovial fluid (SF) white blood cell (WBC) count, SF polymorphonuclear (PMN%), and leukocyte esterase (LE) were calculated...
September 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/28629364/changes-in-concentrations-of-haemostatic-and-inflammatory-biomarkers-in-synovial-fluid-after-intra-articular-injection-of-lipopolysaccharide-in-horses
#11
Stine Mandrup Andreassen, Anne Mette Lindberg Vinther, Søren Saxmose Nielsen, Pia Haubro Andersen, Aziz Tnibar, Annemarie T Kristensen, Stine Jacobsen
BACKGROUND: Septic arthritis is a common and potentially devastating disease characterized by severe intra-articular (IA) inflammation and fibrin deposition. Research into equine joint pathologies has focused on inflammation, but recent research in humans suggests that both haemostatic and inflammatory pathways are activated in the joint compartment in arthritic conditions. The aim of this study was to characterize the IA haemostatic and inflammatory responses in horses with experimental lipopolysaccharide (LPS)-induced joint inflammation...
June 19, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/28463919/synovial-fluid-cell-count-for-diagnosis-of-chronic-periprosthetic-hip-infection
#12
MULTICENTER STUDY
Carlos A Higuera, Benjamin Zmistowski, Tennison Malcom, Wael K Barsoum, Scott M Sporer, Philipp Mommsen, Daniel Kendoff, Craig J Della Valle, Javad Parvizi
BACKGROUND: There is a paucity of data regarding the threshold of synovial fluid white blood-cell (WBC) count and polymorphonuclear cell (neutrophil) percentage of the WBC count (PMN%) for the diagnosis of chronic periprosthetic joint infection (PJI) after total hip arthroplasty. Despite this, many organizations have provided guidelines for the diagnosis of PJI that include synovial fluid WBC count and PMN%. We attempted to define a threshold for synovial fluid WBC count and PMN% for the diagnosis of chronic PJI of the hip using a uniform definition of PJI and to investigate any variations in the calculated thresholds among institutions...
May 3, 2017: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/28367600/microfluidic-processing-of-synovial-fluid-for-cytological-analysis
#13
John C Krebs, Yunus Alapan, Barbara A Dennstedt, Glenn D Wera, Umut A Gurkan
Cytological analysis of synovial fluid is widely used in the clinic to assess joint health and disease. However, in general practice, only the total number of white blood cells (WBCs) are available for cytologic evaluation of the joint. Moreover, sufficient volume of synovial aspirates is critical to run conventional analyses, despite limited volume of aspiration that can normally be obtained from a joint. Therefore, there is a lack of consistent and standardized synovial fluid cytological tests in the clinic...
June 2017: Biomedical Microdevices
https://www.readbyqxmd.com/read/28303585/effect-of-depth-of-centrifuged-synovial-fluid-on-leukocyte-esterase-test-for-periprosthetic-joint-infection
#14
Pakpoom Ruangsomboon, Sriprapa Chinprasertsuk, Varanya Khejonnit, Keerati Chareancholvanich
Centrifugation of aspirated synovial fluid before leukocytes esterase (LE) testing for diagnosing periprosthetic joint infection (PJI) may make blood tinged specimens interpretable. We aimed to establish the proper sampling depth of centrifuged specimens for LE testing as one diagnostic criterion and also AS-D chloroacetate esterase (CAE) staining testing as an adjunctive tool. A definite PJI knee joint group and an aseptic primary total knee arthroplasty control group were studied quasi-experimentally (N = 46)...
November 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/27823373/clinical-features-and-pathological-joint-changes-in-dogs-with-erosive-immune-mediated-polyarthritis-13-cases-2004-2012
#15
Magen L Shaughnessy, Susannah J Sample, Carter Abicht, Caitlin Heaton, Peter Muir
OBJECTIVE To evaluate the clinical features and pathological joint changes in dogs with erosive immune-mediated polyarthritis (IMPA). DESIGN Retrospective case series. ANIMALS 13 dogs with erosive IMPA and 66 dogs with nonerosive IMPA. PROCEDURES The medical record database of a veterinary teaching hospital was reviewed to identify dogs with IMPA that were examined between October 2004 and December 2012. For each IMPA-affected dog, information extracted from the medical record included signalment, diagnostic test results, radiographic findings, and treatments administered...
November 15, 2016: Journal of the American Veterinary Medical Association
https://www.readbyqxmd.com/read/27803833/coexistent-pseudogout-and-mycobacterium-avium-intracellulare-septic-arthritis-in-a-patient-with-hiv-and-esrd
#16
Wais Afzal, Omer M Wali, Kelly L Cervellione, Bhupinder B Singh, Farshad Bagheri
Pseudogout is a crystal-induced arthropathy characterized by the deposition of calcium pyrophosphate dihydrate (CPPD) crystals in synovial fluid, menisci, or articular cartilage. Although not very common, this entity can be seen in patients with chronic kidney disease (CKD). Septic arthritis due to Mycobacterium avium-intracellulare (MAI) is a rare entity that can affect immunocompromised patients such as those with acquired immunodeficiency syndrome (AIDS) or those who are on immunosuppressive drugs. Here, we describe a 51-year-old female who presented with fever, right knee pain, swelling, warmth, and decreased range of motion for several days...
2016: Case Reports in Rheumatology
https://www.readbyqxmd.com/read/27694589/the-diagnostic-thresholds-for-synovial-fluid-analysis-in-late-periprosthetic-infection-of-the-hip-depend-on-the-duration-of-symptoms
#17
H-R Choi, K Agrawal, H Bedair
AIMS: We hypothesised that the synovial white blood cell (WBC) count in patients with a late periprosthetic joint infection (PJI) of the hip would depend on the duration of a patient's symptoms, and that the optimal diagnostic threshold would also depend on this period of time. PATIENTS AND METHODS: The synovial WBC count and percentage of polymorphonuclear cells (%PMN), and the serum CRP and ESR levels obtained > six weeks after primary THA were compared between 50 infected and 88 non-infected THAs, and in patients with symptoms for more than or less than two weeks...
October 2016: Bone & Joint Journal
https://www.readbyqxmd.com/read/27672013/what-is-the-diagnostic-accuracy-of-aspirations-performed-on-hips-with-antibiotic-cement-spacers
#18
Jared M Newman, Jaiben George, Alison K Klika, Stephen F Hatem, Wael K Barsoum, W Trevor North, Carlos A Higuera
BACKGROUND: Periprosthetic joint infection is a serious complication after THA and commonly is treated with a two-stage revision. Antibiotic-eluting cement spacers are placed for local delivery of antibiotics. Aspirations may be performed before the second-stage reimplantation for identification of persistent infection. However, limited data exist regarding the diagnostic parameters of synovial fluid aspiration with or without saline lavage from a hip with an antibiotic-loaded cement spacer...
January 2017: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/27609563/aspergillus-arthritis-analysis-of-clinical-manifestations-diagnosis-and-treatment-of-31-reported-cases
#19
Maria N Gamaletsou, Blandine Rammaert, Marimelle A Bueno, Nikolaos V Sipsas, Brad Moriyama, Dimitrios P Kontoyiannis, Emmanuel Roilides, Valerie Zeller, Saad J Taj-Aldeen, Michael Henry, Vidmantas Petraitis, David W Denning, Olivier Lortholary, Thomas J Walsh
Aspergillus arthritis is a debilitating form of invasive aspergillosis. Little is known about its epidemiology, clinical manifestations, laboratory features, treatment, and prognosis. Cases of Aspergillus arthritis were reviewed in the English literature from 1967 through 2015 for variables of arthritis with Aspergillus spp. recovered from joint and/or adjacent bone, underlying conditions, symptoms, signs, inflammatory biomarkers, diagnostic imaging, management, and outcome. Among 31 evaluable cases, 87% were males and 13% pediatric...
April 1, 2017: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
https://www.readbyqxmd.com/read/27342088/evaluation-of-biomarkers-following-autologous-osteochondral-transplantation-in-the-equine-stifle-joint-an-experimental-study
#20
Pál Tuska, Balázs Tóth, Gábor Vásárhelyi, László Hangody, Miklós Papp, Gábor Bodó
The purpose of this study was to evaluate changes in biomarker and synovial parameters following autologous osteochondral transplantation (AOT) in the equine stifle joint, to test the hypothesis whether synovial parameters would show significant differences at selected time points following the surgery (at days 3, 14, 60 and 180) compared to baseline level (at day 0). Surgical intervention was performed in both stifles of nine horses (n = 18). The joints were randomly assigned to operated and sham-operated groups...
June 2016: Acta Veterinaria Hungarica
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